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https://www.readbyqxmd.com/read/28938787/influence-of-age-and-housing-systems-on-properties-of-tibia-and-humerus-of-lohmann-white-hens1-bone-properties-of-laying-hens-in-commercial-housing-systems
#1
P Regmi, N Nelson, R C Haut, M W Orth, D M Karcher
This study was aimed at analyzing bone properties of Lohmann White hens in different commercial housing systems at various points throughout production. Pullets reared in conventional cages (CC) were either continued in CC or moved to enriched colony cages (EN) at 19 weeks. Pullets reared in cage-free aviaries (AV) were moved to AV hen houses. Bone samples were collected from 60 hens at each of 18 and 72 wk and 30 hens at 26 and 56 wk from each housing system. Left tibiae and humeri were broken under uniform bending to analyze mechanical properties...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938336/arterial-stiffness-induced-by-carotid-calcification-leads-to-cerebral-gliosis-mediated-by-oxidative-stress
#2
Nataliya Sadekova, M Florencia Iulita, Diane Vallerand, Gervais Muhire, Mohamed Bourmoum, Audrey Claing, Hélène Girouard
BACKGROUND: Arterial stiffness is a risk factor for cognitive decline and dementia. However, its precise effects on the brain remain unexplored. Using a mouse model of carotid stiffness, we investigated its effect on glial activation and oxidative stress. METHODS: Arterial stiffness was induced by the application of calcium chloride to the adventitial region of the right carotid. Superoxide anion production, NADPH activity and levels, as well as glial activation were examined with immunohistochemical and biochemical approaches, 2-week postcalcification...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28938023/exploration-of-genetic-architecture-through-sib-ship-reconstruction-in-advanced-breeding-population-of-eucalyptus-nitens
#3
Jaroslav Klápště, Mari Suontama, Emily Telfer, Natalie Graham, Charlie Low, Toby Stovold, Russel McKinley, Heidi Dungey
Accurate inference of relatedness between individuals in breeding population contributes to the precision of genetic parameter estimates, effectiveness of inbreeding management and the amount of genetic progress delivered from breeding programs. Pedigree reconstruction has been proven to be an efficient tool to correct pedigree errors and recover hidden relatedness in open pollinated progeny tests but the method can be limited by the lack of parental genotypes and the high proportion of alien pollen from outside the breeding population...
2017: PloS One
https://www.readbyqxmd.com/read/28937784/lacertus-fibrosus-versus-achilles-allograft-reconstruction-for-distal-biceps-tears-a-biomechanical-study
#4
Anand M Murthi, Miguel A Ramirez, Brent G Parks, Shannon R Carpenter
BACKGROUND: The bicipital aponeurosis, or lacertus fibrosus, can potentially be used as a reconstruction graft in chronic distal biceps tendon tears. PURPOSE: To evaluate construct stiffness, load to failure, and failure mechanism with lacertus fibrosus versus Achilles allograft for distal biceps tendon reconstruction. STUDY DESIGN: Controlled laboratory study. METHODS: Ten fresh-frozen matched cadaveric pairs of elbows were used...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28937643/design-and-additive-manufacturing-of-3d-phononic-band-gap-structures-based-on-gradient-based-optimization
#5
Maximilian Wormser, Fabian Wein, Michael Stingl, Carolin Körner
We present a novel approach for gradient based maximization of phononic band gaps. The approach is a geometry projection method combining parametric shape optimization with density based topology optimization. By this approach, we obtain, in a two dimension setting, cellular structures exhibiting relative and normalized band gaps of more than 8 and 1.6, respectively. The controlling parameter is the minimal strut size, which also corresponds with the obtained stiffness of the structure. The resulting design principle is manually interpreted into a three dimensional structure from which cellular metal samples are fabricated by selective electron beam melting...
September 22, 2017: Materials
https://www.readbyqxmd.com/read/28936909/predictors-of-chronic-pain-following-total-knee-replacement-in-females-and-males-an-exploratory-study
#6
Tanja Bossmann, Torsten Brauner, Scott Wearing, Thomas Horstmann
AIM: This study explored whether nociceptive (NS) and autonomic nervous system (ANS) dysregulation and psychological distress were predictive of pain 6 months after primary total knee replacement. PATIENTS & METHODS: ANS and NS regulation, psychological distress and self-reported pain, stiffness and function were evaluated preoperatively in 56 patients. Pain severity measured 6 months after surgery was used as the primary outcome in an analysis of covariance model...
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28936808/impact-of-tocilizumab-monotherapy-on-clinical-and-patient-reported-quality-of-life-outcomes-in-patients-with-rheumatoid-arthritis
#7
Leslie R Harrold, Ani John, George W Reed, Tmirah Haselkorn, Chitra Karki, YouFu Li, Jennie Best, Steve Zlotnick, Joel M Kremer, Jeffrey D Greenberg
INTRODUCTION: Tocilizumab (TCZ) monotherapy has been proven as an effective treatment for rheumatoid arthritis (RA) in clinical trials. However, there are limited data available regarding the effectiveness of TCZ monotherapy in real-world clinical settings in the United States. The objective of this study was to evaluate the impact of TCZ monotherapy on disease activity and patient-reported outcomes (PROs) in a US-based observational cohort of patients with RA seen in routine clinical practice...
September 21, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28936433/trpc3-channels-in-cardiac-fibrosis
#8
REVIEW
Takuro Numaga-Tomita, Sayaka Oda, Tsukasa Shimauchi, Akiyuki Nishimura, Supachoke Mangmool, Motohiro Nishida
Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF). Canonical transient receptor potential (TRPC) subfamily proteins are components of Ca(2+)-permeable non-selective cation channels activated by receptor stimulation and mechanical stress, and have been attracted attention as a key mediator of maladaptive cardiac remodeling. How TRPC-mediated local Ca(2+) influx encodes a specific signal to induce maladaptive cardiac remodeling has been long obscure, but our recent studies suggest a pathophysiological significance of channel activity-independent function of TRPC proteins for amplifying redox signaling in heart...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28935964/impact-of-mitochondrial-nitrite-reductase-on-hemodynamics-and-myocardial-contractility
#9
Peter Dungel, Carina Penzenstadler, Mostafa Ashmwe, Sergiu Dumitrescu, Tanja Stoegerer, Heinz Redl, Soheyl Bahrami, Andrey V Kozlov
Inorganic nitrite (NO2(-)) can be reduced back to nitric oxide (NO) by several heme proteins called nitrite reductases (NR) which affect both the vascular tonus and hemodynamics. The objective of this study was to clarify the impact of several NRs on the regulation of hemodynamics, for which hemodynamic parameters such as heart rate, blood pressure, arterial stiffness, peripheral resistance and myocardial contractility were characterized by pulse wave analysis. We have demonstrated that NO2(-) reduced to NO in RBCs predominantly influences the heart rate, while myoglobin (Mb) and mitochondria-derived NO regulates arterial stiffness, peripheral resistance and myocardial contractility...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935634/assessment-of-left-ventricular-function-and-peripheral-vascular-arterial-stiffness-in-patients-with-dipper-and-non-dipper-hypertension
#10
Yan Chen, Ju-Hua Liu, Zhe Zhen, Yuan Zuo, Qingshan Lin, Mingya Liu, Chunting Zhao, Min Wu, Gaozhen Cao, Run Wang, Hung-Fat Tse, Kai-Hang Yiu
A non-dipper pattern of high blood pressure is associated with increased risk of organ damage and cardiovascular disease in patients with hypertension. The aim of the study was to evaluate the left ventricular (LV) remodeling and function and arterial stiffness in a dipper/non-dipper pattern of high blood pressure in patients with hypertension. A total of 183 hypertensive patients with no history of adverse cardiovascular events were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 66 patients with a dipper pattern and 117 patients with non-dipper pattern...
September 20, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28935379/knotless-double-row-suturebridge-rotator-cuff-repairs-have-improved-self-reinforcement-compared-with-double-row-suturebridge-repairs-with-tied-medial-knots-a-biomechanical-study-using-an-ovine-model
#11
Geoffrey C S Smith, Theresia M Bouwmeester, Patrick H Lam
BACKGROUND: In double-row SutureBridge (Arthrex, Naples, FL, USA) rotator cuff repairs, increasing tendon load may generate progressively greater compression forces at the repair footprint (self-reinforcement). SutureBridge rotator cuff repairs using tied horizontal mattress sutures medially may limit this effect compared with a knotless construct. MATERIALS AND METHODS: Rotator cuff repairs were performed in 9 pairs of ovine shoulders. One group underwent repair with a double-row SutureBridge construct with tied horizontal medial-row mattress sutures...
September 18, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28935371/a-sir2-family-protein-rv1151c-deacetylates-hu-to-alter-its-dna-binding-mode-in-mycobacterium-tuberculosis
#12
Chinmay Anand, Rajni Garg, Soumitra Ghosh, Valakunja Nagaraja
Till recently, knowledge about epigenetic regulation in bacterial world confined largely to DNA methylation. Lysine acetylation/deacetylation of histones is a major contributor for chromatin dynamics in eukaryotes. However, little is known about such epigenetic changes brought about by post-translational modifications in bacteria. Here, we describe an example of such mechanism occurring in a histone like protein, HU from Mycobacterium tuberculosis (Mtb). Previously, we demonstrated the interaction and acetylation of Mtb HU (MtHU) by one of the acetyl transferases, Eis...
September 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28935340/risk-factors-outcomes-and-timing-of-manipulation-under-anesthesia-after-total-knee-arthroplasty
#13
Erik T Newman, Thomas A Herschmiller, David E Attarian, Thomas P Vail, Michael P Bolognesi, Samuel S Wellman
BACKGROUND: Knee stiffness requiring manipulation under anesthesia (MUA) is an undesirable outcome following total knee arthroplasty (TKA), but risk factors for, and optimal timing of, MUA remain unclear. METHODS: Primary TKAs performed at a single center were retrospectively reviewed. Clinical variables were compared between patients who underwent MUA and those who did not; variables that differed were utilized to identify an appropriately matched control group of non-MUA patients...
August 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28934928/complexity-of-pathomechanisms-leading-to-diastolic-heart-failure-in-diabetes-mellitus-potential-field-for-therapeutic-interventions
#14
Michael Schwarzer, Michel Noutsias, Frank Spillmann, P Christian Schulze, Torsten Doenst, Carsten Tschöpe
Advanced glycation end products (AGE) have been implicated in diabetes associated complications. They have been suggested as potential mediators in the progression of diabetic heart failure and as a potential target for treatment. Brunvand et al. now provided evidence in that the suggested causal relationship between AGE and diastolic myocardial dysfunction cannot be confirmed in children with type 1 diabetes. The early signs of diastolic myocardial impairment were associated with higher BMI, but not with HbA1c levels...
September 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28934883/contrast-enhanced-computed-tomography-enables-quantitative-evaluation-of-tissue-properties-at-intrajoint-regions-in-cadaveric-knee-cartilage
#15
Rachel C Stewart, Juuso T J Honkanen, Harri T Kokkonen, Virpi Tiitu, Simo Saarakkala, Antti Joukainen, Brian D Snyder, Jukka S Jurvelin, Mark W Grinstaff, Juha Töyräs
Objective The aim of this study was to investigate whether the concentration of the anionic contrast agent ioxaglate, as quantitated by contrast-enhanced computed tomography (CECT) using a clinical cone-beam CT (CBCT) instrument, reflects biochemical, histological, and biomechanical characteristics of articular cartilage imaged in an ex vivo, intact human knee joint. Design An osteoarthritic human cadaveric knee joint (91 years old) was injected with ioxaglate (36 mg I/mL) and imaged using CBCT over 61 hours of ioxaglate diffusion into cartilage...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934812/prediction-of-pathological-complete-response-to-neoadjuvant-chemotherapy-for-primary-breast-cancer-comparing-interim-ultrasound-shear-wave-elastography-and-mri
#16
Andrew Evans, Patsy Whelehan, Alastair Thompson, Colin Purdie, Lee Jordan, Jane Macaskill, Shelley Waugh, Frances Fuller-Pace, Katrin Brauer, Sarah Vinnicombe
Background Prediction of pathological complete response (pCR) of primary breast cancer to neoadjuvant chemotherapy (NACT) may influence planned surgical approaches in the breast and axilla. The aim of this project is to assess the value of interim shear wave elastography (SWE), ultrasound (US) and magnetic resonance imaging (MRI) after 3 cycles in predicting pCR. Methods 64 patients receiving NACT had baseline and interim US, SWE and MRI examinations. The mean lesion stiffness at SWE, US and MRI diameter was measured at both time points...
September 21, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28934719/exposure-to-road-railway-and-aircraft-noise-and-arterial-stiffness-in-the-sapaldia-study-annual-average-noise-levels-and-temporal-noise-characteristics
#17
Maria Foraster, Ikenna C Eze, Emmanuel Schaffner, Danielle Vienneau, Harris Héritier, Simon Endes, Franziska Rudzik, Laurie Thiesse, Reto Pieren, Christian Schindler, Arno Schmidt-Trucksäss, Mark Brink, Christian Cajochen, Jean Marc Wunderli, Martin Röösli, Nicole Probst-Hensch
BACKGROUND: The impact of different transportation noise sources and noise environments on arterial stiffness remains unknown. OBJECTIVES: We evaluated the association between residential outdoor exposure to annual average road, railway, and aircraft noise levels, total noise intermittency (IR), and total number of noise events (NE) and brachial-ankle pulse wave velocity (baPWV) following a cross-sectional design. METHODS: We measured baPWV (meters/second) in 2,775 participants (49-81 y old) at the second follow-up (2010-2011) of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA)...
September 7, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934633/association-of-low-back-pain-with-muscle-stiffness-and-muscle-mass-of-the-lumbar-back-muscles-and-sagittal-spinal-alignment-in-young-and-middle-aged-medical-workers
#18
Mitsuhiro Masaki, Tomoki Aoyama, Takashi Murakami, Ko Yanase, Xiang Ji, Hiroshige Tateuchi, Noriaki Ichihashi
BACKGROUND: Muscle stiffness of the lumbar back muscles in low back pain (LBP) patients has not been clearly elucidated because quantitative assessment of the stiffness of individual muscles was conventionally difficult. This study aimed to examine the association of LBP with muscle stiffness assessed using ultrasonic shear wave elastography (SWE) and muscle mass of the lumbar back muscle, and spinal alignment in young and middle-aged medical workers. METHODS: The study comprised 23 asymptomatic medical workers [control (CTR) group] and 9 medical workers with LBP (LBP group)...
September 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28934161/improving-the-process-of-adjusting-the-parameters-of-finite-element-models-of-healthy-human-intervertebral-discs-by-the-multi-response-surface-method
#19
Fátima Somovilla Gómez, Rubén Lostado Lorza, Marina Corral Bobadilla, Rubén Escribano García
The kinematic behavior of models that are based on the finite element method (FEM) for modeling the human body depends greatly on an accurate estimate of the parameters that define such models. This task is complex, and any small difference between the actual biomaterial model and the simulation model based on FEM can be amplified enormously in the presence of nonlinearities. The current paper attempts to demonstrate how a combination of the FEM and the MRS methods with desirability functions can be used to obtain the material parameters that are most appropriate for use in defining the behavior of Finite Element (FE) models of the healthy human lumbar intervertebral disc (IVD)...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28934116/experimental-comparison-of-different-carbon-fiber-composites-in-reinforcement-layouts-for-wooden-beams-of-historical-buildings
#20
Francisco J Rescalvo, Ignacio Valverde-Palacios, Elisabet Suarez, Antolino Gallego
This paper offers a detailed, quantitative and exhaustive experimental comparison in terms of mechanical properties of three different layouts of carbon composite materials (CFRP) used to strengthen existing old timber beams highly affected by diverse natural defects and biological attacks, testing the use of pultruded laminate attached on the tension side of the element (LR), CFRP fabrics totally U-shape wrapping the timber element (UR), and the combined use of both reinforcement solutions (UR-P). Moreover, unidirectional and bidirectional fabrics were considered and compared...
September 21, 2017: Materials
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