keyword
MENU ▼
Read by QxMD icon Read
search

Mechanosensing

keyword
https://www.readbyqxmd.com/read/29340386/on-chip-functional-neuroimaging-with-mechanical-stimulation-in-caenorhabditis-elegans-larvae-for-studying-development-and-neural-circuits
#1
Yongmin Cho, David N Oakland, Sol Ah Lee, William R Schafer, Hang Lu
Mechanosensation is fundamentally important for the abilities of an organism to experience touch, hear sounds, and maintain balance. Caenorhabditis elegans is a powerful system for studying mechanosensation as this worm is well suited for in vivo functional imaging of neurons. Many years of research using labor-intensive methods have generated a wealth of knowledge about mechanosensation in C. elegans, and the recent microfluidic-based platforms continue to push the boundary for this field. However, developmental aspects of sensory biology, including mechanosensation, are still not fully understood...
January 17, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29339793/skin-inspired-highly-stretchable-and-conformable-matrix-networks-for-multifunctional-sensing
#2
Qilin Hua, Junlu Sun, Haitao Liu, Rongrong Bao, Ruomeng Yu, Junyi Zhai, Caofeng Pan, Zhong Lin Wang
Mechanosensation electronics (or Electronic skin, e-skin) consists of mechanically flexible and stretchable sensor networks that can detect and quantify various stimuli to mimic the human somatosensory system, with the sensations of touch, heat/cold, and pain in skin through various sensory receptors and neural pathways. Here we present a skin-inspired highly stretchable and conformable matrix network (SCMN) that successfully expands the e-skin sensing functionality including but not limited to temperature, in-plane strain, humidity, light, magnetic field, pressure, and proximity...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29330498/replication-of-biocompatible-nanotopographic-surfaces
#3
Xiaoyu Sun, Matt J Hourwitz, Eleni M Baker, B U Sebastian Schmidt, Wolfgang Losert, John T Fourkas
The ability of cells to sense and respond to nanotopography is being implicated as a key element in many physiological processes such as cell differentiation, immune response, and wound healing, as well as in pathologies such as cancer metastasis. To understand how nanotopography affects cellular behaviors, new techniques are required for the mass production of biocompatible, rigid nanotopographic surfaces. Here we introduce a method for the rapid and reproducible production of biocompatible, rigid, acrylic nanotopographic surfaces, and for the functionalization of the surfaces with adhesion-promoting molecules for cell experiments...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318681/shape-memory-polymers-for-body-motion-energy-harvesting-and-self-powered-mechanosensing
#4
Ruiyuan Liu, Xiao Kuang, Jianan Deng, Yi-Cheng Wang, Aurelia C Wang, Wenbo Ding, Ying-Chih Lai, Jun Chen, Peihong Wang, Zhiqun Lin, H Jerry Qi, Baoquan Sun, Zhong Lin Wang
Growing demand in portable electronics raises a requirement to electronic devices being stretchable, deformable, and durable, for which functional polymers are ideal choices of materials. Here, the first transformable smart energy harvester and self-powered mechanosensation sensor using shape memory polymers is demonstrated. The device is based on the mechanism of a flexible triboelectric nanogenerator using the thermally triggered shape transformation of organic materials for effectively harvesting mechanical energy...
January 10, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29317663/trpv1-enhances-the-afferent-response-to-p2x-receptor-activation-in-the-mouse-urinary-bladder
#5
Luke Grundy, Donna M Daly, Christopher Chapple, David Grundy, Russ Chess-Williams
Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been implicated in mechanosensation during bladder filling. The aim of this study was to determine possible interactions between these receptors in modulating afferent nerve activity. In wildtype (TRPV1+/+) and TRPV1 knockout (TRPV1-/-) mice, bladder afferent nerve activity, intravesical pressure, and luminal ATP and acetylcholine levels were determined and also intracellular calcium responses of dissociated pelvic DRG neurones and primary mouse urothelial cells (PMUCs)...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29295934/computational-modeling-of-three-dimensional-ecm-rigidity-sensing-to-guide-directed-cell-migration
#6
Min-Cheol Kim, Yaron R Silberberg, Rohan Abeyaratne, Roger D Kamm, H Harry Asada
Filopodia have a key role in sensing both chemical and mechanical cues in surrounding extracellular matrix (ECM). However, quantitative understanding is still missing in the filopodial mechanosensing of local ECM stiffness, resulting from dynamic interactions between filopodia and the surrounding 3D ECM fibers. Here we present a method for characterizing the stiffness of ECM that is sensed by filopodia based on the theory of elasticity and discrete ECM fiber. We have applied this method to a filopodial mechanosensing model for predicting directed cell migration toward stiffer ECM...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29282607/mechanism-of-the-reconstruction-of-aqueous-outflow-drainage
#7
REVIEW
Chen Xin, Ning Tian, Meng Li, Huaizhou Wang, Ningli Wang
Glaucoma is the leading cause of irreversible blindness worldwide. The reconstruction of aqueous outflow drainage (RAOD) has recently been proposed to aid in restoring aqueous outflow drainage in primary open-angle glaucoma. However, the mechanism of RAOD remains to be fully understood. Based on literature review and research studies, the potential mechanisms of RAOD are the following: (i) Circumferential dilation of the Schlemm's canal (SC) and surrounding collector channels. (ii) Instant formation of microcracks through RAOD procedures...
December 22, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29277899/proton-independent-activation-of-acid-sensing-ion-channel-asic3-by-alkaloid-lindoldhamine-from-laurus-nobilis
#8
Dmitry I Osmakov, Sergey G Koshelev, Yaroslav A Andreev, Maxim A Dubinnyi, Vadim S Kublitski, Roman G Efremov, Alexander I Sobolevsky, Sergey A Kozlov
BACKGROUND AND PURPOSE: Acid-sensing ion channels (ASICs) play an important role in synaptic plasticity and learning, as well as in nociception and mechanosensation. ASICs are implicated in pain, neurological and psychiatric diseases but their therapeutic potential is limited by lack of ligands activating them at physiological pH. EXPERIMENTAL APPROACH: Here we report extraction from laurel leaves, purification and structure determination of a bisbenzylisoquinoline alkaloid lindoldhamine (LIN) and characterization of its effect on ASIC3 channels using two-electrode voltage-clamp electrophysiological recordings from Xenopus laevis oocytes...
December 26, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29261283/transparent-and-self-powered-multi-stage-sensation-matrix-for-mechanosensation-application
#9
Qian Zhang, Tao Jiang, Dong Hae Ho, Shanshan Qin, Xixi Yang, Jeong Ho Cho, Qijun Sun, Zhong Lin Wang
Electronic skin based on multimodal sensing array is ready to detect various stimuli in different categories by utilizing highly sensitive materials, sophisticated geometry designs, and integration of multifunctional sensors. However, it is still difficult to distinguish multiple and complex mechanical stimuli in a local position by conventional multimodal E-skin, which is significantly important in the signals feedback of robotic fine motions and human-machine interactions. Here, we present a transparent, flexible and self-powered multi-stage sensation matrix based on piezoelectric nanogenerators (NGs) constructed in a crossbar design...
December 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29251568/integrated-simultaneous-detection-of-tactile-and-bending-cues-for-soft-robotics
#10
Massimo Totaro, Alessio Mondini, Andrea Bellacicca, Paolo Milani, Lucia Beccai
Soft robots should move in an unstructured environment and explore it and, to do so, they should be able to measure and distinguish proprioceptive and exteroceptive stimuli. This can be done by embedding mechanosensing systems in the body of the robot. Here, we present a polydimethylsiloxane block sensorized with an electro-optical system and a resistive strain gauge made with the supersonic cluster beam implantation (SCBI) technique. We show how to integrate these sensing elements during the whole fabrication process of the soft body and we demonstrate that their presence does not change the mechanical properties of the bulk material...
December 2017: Soft Robotics
https://www.readbyqxmd.com/read/29234037/dynamic-regulation-of-trek1-gating-by-polycystin-2-via-a-filamin-a-mediated-cytoskeletal-mechanism
#11
Steven Li Fraine, Amanda Patel, Fabrice Duprat, Reza Sharif-Naeini
Mechanosensing is essential for several physiological functions including touch and pain sensations, osmoregulation, and controlling the myogenic tone of resistance arteries. Understanding how mechanosensitive ion channels (MSCs) are gated can provide important information regarding these processes. We have previously demonstrated that during pathological conditions such as polycystic kidney disease, polycystin 2 (TRPP2) inhibits the activity of potassium-selective MSCs through a filamin A-mediated cytoskeletal effect, and renders tubular epithelial cells susceptible to apoptosis...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228535/the-role-of-piezo2-in-human-mechanosensation
#12
Nima Rezaei, Amene Saghazadeh
No abstract text is available yet for this article.
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29217091/microstructural-changes-associated-with-osteoporosis-negatively-affect-loading-induced-fluid-flow-around-osteocytes-in-cortical-bone
#13
Vittorio Gatti, Evan M Azoulay, Susannah P Fritton
Loading-induced interstitial fluid flow in the microporosities of bone is critical for osteocyte mechanotransduction and for the maintenance of tissue health, enhancing convective transport in the lacunar-canalicular system. In recent studies, our group has reported alterations of bone's vascular porosity and lacunar-canalicular system microarchitecture in a rat model of postmenopausal osteoporosis. In this work, poroelastic finite element analysis was used to investigate whether these microstructural changes can affect interstitial fluid flow around osteocytes...
November 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29216451/mechanosensory-based-phase-coding-of-odor-identity-in-the-olfactory-bulb
#14
Ryo Iwata, Hiroshi Kiyonari, Takeshi Imai
Mitral and tufted (M/T) cells in the olfactory bulb produce rich temporal patterns of activity in response to different odors. However, it remains unknown how these temporal patterns are generated and how they are utilized in olfaction. Here we show that temporal patterning effectively discriminates between the two sensory modalities detected by olfactory sensory neurons (OSNs): odor and airflow-driven mechanical signals. Sniff-induced mechanosensation generates glomerulus-specific oscillatory activity in M/T cells, whose phase was invariant across airflow speed...
December 6, 2017: Neuron
https://www.readbyqxmd.com/read/29212889/stem-cell-differentiation-is-regulated-by-extracellular-matrix-mechanics
#15
REVIEW
Lucas R Smith, Sangkyun Cho, Dennis E Discher
Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.
January 1, 2018: Physiology
https://www.readbyqxmd.com/read/29212020/mechanotransmission-and-mechanosensing-of-human-alpha-actinin-1
#16
Shimin Le, Xian Hu, Mingxi Yao, Hu Chen, Miao Yu, Xiaochun Xu, Naotaka Nakazawa, Felix M Margadant, Michael P Sheetz, Jie Yan
α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in focal adhesion maturation. However, the molecular mechanisms underlying its functions are unclear. Here, by mechanical manipulation of single human α-actinin 1 using magnetic tweezers, we determined the mechanical stability and kinetics of the functional domains in α-actinin 1...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29206857/z-disc-protein-chapb-induces-cardiomyopathy-and-contractile-dysfunction-in-the-postnatal-heart
#17
Willemijn van Eldik, Brigit den Adel, Jantine Monshouwer-Kloots, Daniela Salvatori, Saskia Maas, Ingeborg van der Made, Esther E Creemers, Derk Frank, Norbert Frey, Nicky Boontje, Jolanda van der Velden, Paul Steendijk, Christine Mummery, Robert Passier, Abdelaziz Beqqali
AIMS: The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for cardiac and skeletal muscle development. Furthermore, the CHAP gene has been associated with atrial fibrillation in humans. Here, we studied the misregulated expression of CHAP isoforms in heart disease...
2017: PloS One
https://www.readbyqxmd.com/read/29202470/polycystin-1-interacts-with-taz-to-stimulate-osteoblastogenesis-and-inhibit-adipogenesis
#18
Zhousheng Xiao, Jerome Baudry, Li Cao, Jinsong Huang, Hao Chen, Charles R Yates, Wei Li, Brittany Dong, Christopher M Waters, Jeremy C Smith, L Darryl Quarles
The molecular mechanisms that transduce the osteoblast response to physical forces in the bone microenvironment are poorly understood. Here, we used genetic and pharmacological experiments to determine whether the polycystins PC1 and PC2 (encoded by Pkd1 and Pkd2) and the transcriptional coactivator TAZ form a mechanosensing complex in osteoblasts. Compound-heterozygous mice lacking 1 copy of Pkd1 and Taz exhibited additive decrements in bone mass, impaired osteoblast-mediated bone formation, and enhanced bone marrow fat accumulation...
November 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29198699/activation-of-pkb-akt-and-p44-42-by-mechanical-stretch-utilizes-desmosomal-structures-and-the-keratin-filament
#19
Stefan Kippenberger, Johannes Kleemann, Markus Meissner, Katja Steinhorst, Jutta Müller, Christos C Zouboulis, Roland Kaufmann, Nadja Zöller
BACKGROUND: Mechanical stress is an ubiquitous challenge of human cells with fundamental impact on cell physiology. Previous studies have shown that stretching promotes signalling cascades involved in proliferation and tissue enlargement. OBJECTIVE: The present study is dedicated to learn more about cellular structures contributing to perception and signal transmission of cell stretch. In particular, we hypothesized that desmosmal contacts and the adjacent keratin filament build an intercellular matrix providing information about the mechanical load...
November 30, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29197863/proteomic-analysis-reveals-grb2-as-a-key-regulator-of-periodic-mechanical-stress-transduction-in-chondrocytes
#20
Shun Xu, Zeng Li, Zhen Wang, Chenjun Zhai, Wenwei Liang, Chunhui Zhu, Weimin Fan
BACKGROUND/AIMS: Periodic mechanical stress could significantly promote chondrocyte proliferation and matrix synthesis. However, the mechanisms underlying the ability of chondrocyte detecting and responding to periodic mechanical stimuli have not been well delineated. METHODS: Quantitative proteomic analysis was performed to construct the differently expressed proteome profiles of chondrocyte under pressure. Then a combination of Western blot, quantitative real-time PCR, lentiviral vector and histological methods were used to confirm the proteomic results and investigate the mechanoseing mechanism...
December 4, 2017: Cellular Physiology and Biochemistry
keyword
keyword
20435
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"