Jan Bączek, Mirosław Charkiewicz, Agnieszka Kasiukiewicz, Anna Maria Witkowska, Łukasz Magnuszewski, Marta Bączek, Zyta Beata Wojszel
Background: Chronic heart failure (CHF) is a complex clinical syndrome associated with muscle wasting, which can progress to cardiac cachexia. Myostatin, a negative regulator of muscle growth, has been implicated in the pathophysiology of muscle wasting in CHF patients and suggested as a potential biomarker. The objective of this study was to investigate serum myostatin concentration in patients with CHF with preserved and reduced ejection fraction. Methods: The authors conducted a single-centre study comparing serum myostatin levels, functional and echocardiographic parameters, muscle mass, strength and function in patients with CHF to a control group without CHF...
March 18, 2024: Journal of Clinical Medicine