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https://www.readbyqxmd.com/read/29755574/branched-chain-amino-acids-in-health-and-disease-metabolism-alterations-in-blood-plasma-and-as-supplements
#1
REVIEW
Milan Holeček
Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids with protein anabolic properties, which have been studied in a number of muscle wasting disorders for more than 50 years. However, until today, there is no consensus regarding their therapeutic effectiveness. In the article is demonstrated that the crucial roles in BCAA metabolism play: (i) skeletal muscle as the initial site of BCAA catabolism accompanied with the release of alanine and glutamine to the blood; (ii) activity of branched-chain keto acid dehydrogenase (BCKD); and (iii) amination of branched-chain keto acids (BCKAs) to BCAAs...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29749287/a-qualitative-exploration-of-weight-bias-and-quality-of-health-care-among-health-care-professionals-using-hypothetical-patient-scenarios
#2
Justine Seymour, Jennifer L Barnes, Julie Schumacher, Rachel L Vollmer
The purpose of this study was to determine whether weight bias exhibited by health care professionals (HCPs) impacts quality of health care provided to individuals with obesity. HCPs (n = 220; 88% female, 87% nurses) in the Midwest region of the United States were recruited to complete an online survey. In this within-subjects study design, participants completed the Attitudes Towards Obese Persons (ATOP) scale to assess weight bias and responded to 2 (1 person with obesity and 1 person without obesity) hypothetical patient scenarios to evaluate quality of care...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29738109/sarcopenic-obesity-in-cirrhosis-the-confluence-of-two-prognostic-titans
#3
Tannaz Eslamparast, Aldo J Montano-Loza, Maitreyi Raman, Puneeta Tandon
Sarcopenia and obesity are two major health conditions with a growing prevalence in cirrhosis. The concordance of these two conditions, sarcopenic obesity, is associated with higher rates of mortality and impact on the metabolic profile and physical function than either condition alone. To date, there is little consensus surrounding the diagnostic criteria for sarcopenia, obesity or as a result, sarcopenic obesity in patients with cirrhosis. Cross-sectional imaging, although the most accurate diagnostic technique, has practical limitations for routine use in clinical practice...
May 8, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29736403/temporal-trends-in-gestational-diabetes-prevalence-treatment-and-outcomes-at-aarhus-university-hospital-skejby-between-2004-and-2016
#4
Per Glud Ovesen, Jens Fuglsang, Mette Bisgaard Andersen, Charlotte Wolff, Olav Bjørn Petersen, H David McIntyre
Background: The prevalence of gestational diabetes (GDM) is increasing worldwide. The most important risk of GDM in pregnancy is excessive fetal growth, increasing the risk of complications during delivery as well as long-term complications like obesity and diabetes in both the mother and the offspring. Method: All women with GDM who delivered a singleton between 2004 and 2016 were included. The treatment of GDM patients sought to achieve normal blood glucose levels, primarily by diet and exercise...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29716978/therapy-of-endocrine-disease-growth-hormone-replacement-therapy-in-adults-thirty-years-of-personal-clinical-experience
#5
Jens Otto L Jorgensen, Anders Juul
The acute metabolic actions of purified human GH was first documented in adult hypopituitary patients more than 50 years ago, and placebo controlled long term GH trials in GH-deficient adults (GHDA) surfaced in 1989 with the availability of biosynthetic human GH. Untreated GHDA is associated with excess morbidity and mortality from cardiovascular disease and the phenotype includes fatigue, reduced aerobic exercise capacity, abdominal obesity, reduced lean body mass, osteopenia, and elevated levels of circulating cardiovascular biomarkers...
May 1, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29686977/a-prototype-exercise-empowerment-mobile-video-game-for-children-with-cancer-and-its-usability-assessment-developing-digital-empowerment-interventions-for-pediatric-diseases
#6
Carol S Bruggers, Sabrina Baranowski, Mathew Beseris, Rachel Leonard, Derek Long, Elizabeth Schulte, Ashton Shorter, Rowan Stigner, Clinton C Mason, Alisa Bedrov, Ian Pascual, Grzegorz Bulaj
Background: Medical advances continue to improve morbidity and mortality of serious pediatric diseases, including cancer, driving research addressing diminished physical and psychological quality of life in children with these chronic conditions. Empowerment enhances resilience and positively influences health, disease, and therapy understanding. We describe the development and usability assessment of a prototype Empower Stars! mobile video game grounded in behavioral and exercise theories with the purpose of coupling physical exercise with empowerment over disease in children with cancer...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29649791/the-long-term-impact-of-high-levels-of-alpha-melanocyte-stimulating-hormone-in-energy-balance-among-obese-adolescents
#7
Ana Claudia Pelissari Kravchychyn, Raquel Munhoz da Silveira Campos, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Sofia Emanuelle de Castro Ferreira Vicente, Yasmin Alaby Martins Ferreira, Patrícia Leão Silva, Aline de Piano Ganen, Lila Missae Oyama, Lian Tock, Marco Túlio de Mello, Sérgio Tufik, Ana Raimunda Dâmaso
BACKGROUND: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents...
April 12, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29600947/disease-activity-overweight-physical-activity-and-screen-time-in-a-cohort-of-patients-with-juvenile-idiopathic-arthritis
#8
Gilad Sherman, Dan Nemet, Veronica Moshe, Alessandro Consolaro, Angelo Ravelli, Nicolino Ruperto, Yosef Uziel
OBJECTIVES: Physical activity is an important part of children's health and social development. Juvenile idiopathic arthritis (JIA) can lead to decreased physical activity and quality of life. This study characterised clinical aspects, physical activity rates, obesity, and screen time in a group of JIA patients. METHODS: Ninety-seven JIA patients in the Paediatric Rheumatology Clinic at Meir Medical Center were evaluated over a 6-month period and compared by statistical methods to 98 age-matched healthy controls...
March 21, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29596311/the-effects-of-isoflavone-supplementation-plus-combined-exercise-on-lipid-levels-and-inflammatory-and-oxidative-stress-markers-in-postmenopausal-women
#9
Jéssica S Giolo, Juliene G Costa, Jair P da Cunha-Junior, Ana Cláudia A M Pajuaba, Ernesto A Taketomi, Adriele V de Souza, Douglas C Caixeta, Leonardo G Peixoto, Erick P de Oliveira, Sarah Everman, Foued S Espindola, Guilherme M Puga
This study tested the effect of isoflavone supplementation in addition to combined exercise training on plasma lipid levels, inflammatory markers and oxidative stress in postmenopausal women. Thirty-two healthy and non-obese postmenopausal women without hormone therapy were randomly assigned to exercise + placebo (PLA; n = 15) or exercise + isoflavone supplementation (ISO; n = 17) groups. They performed 30 sessions of combined exercises (aerobic plus resistance) over ten weeks and consumed 100 mg of isoflavone supplementation or placebo...
March 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29578204/differences-in-gene-expression-related-to-the-results-of-obesity-treatment-peak-oxygen-uptake-and-fatty-acid-metabolism-measured-in-a-cardiopulmonary-exercise-test
#10
Marta Gruchała-Niedoszytko, Pieter van der Vlies, Piotr Niedoszytko, Bahram Sanjabi, Marek Niedoszytko, Małgorzata Kaczkan, Magdalena Pieszko, Katarzyna Gierat-Haponiuk, Aleksandra Śliwińska, Dominika Szalewska, Sylwia Małgorzewicz
INTRODUCTION    The impact of obesity requires methods used on a large scale as  cardiopulmonary exercise test (CPET). The gene expression may explain CPET results on molecular level.   OBJECTIVES    The aim of the study was to compare gene expression in obesity,  differences related to the CPET results. PATIENTS AND METHODS    The study group consisted of 9 obese and 7 controls. The treatment consisted of diet, rehabilitation, behavioural therapy. Diet was based on the body composition analysed by bioelectrical impedance (BIA), resting metabolic rate, and subjective patients' preferences...
March 26, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29573216/glucose-impairments-and-insulin-resistance-in-prostate-cancer-the-role-of-obesity-nutrition-and-exercise
#11
REVIEW
K M Di Sebastiano, J H Pinthus, W C M Duivenvoorden, M Mourtzakis
BACKGROUND: Hyperinsulinemia, obesity and related metabolic diseases are associated with prostate cancer development. Prostate cancer patients undergoing androgen deprivation therapy (ADT) are at increased risk for metabolic syndrome, cardiovascular disease and diabetes, while pre-existing metabolic conditions may be exacerbated. PURPOSE: An integrative approach is used to describe the interactions between insulin, glucose metabolism, obesity and prostate cancer...
March 24, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29545327/how-i-treat-the-post-thrombotic-syndrome
#12
Anat Rabinovich, Susan R Kahn
The post-thrombotic syndrome (PTS) is a chronic complication of deep vein thrombosis (DVT) that imposes significant morbidity, reduces quality of life and is costly. After DVT, 20-50% of patients will develop PTS, and up to 5% will develop severe PTS. The principal risk factors for PTS are anatomically extensive DVT, recurrent ipsilateral DVT, obesity and older age. By preventing the initial DVT and DVT recurrence, primary and secondary prophylaxis of DVT will reduce the occurrence of PTS. The effectiveness of elastic compression stockings (ECS) for PTS prevention is controversial...
March 15, 2018: Blood
https://www.readbyqxmd.com/read/29515458/exercise-arterial-crosstalk-modulation-and-inflammation-in-an-aging-population-the-examin-age-study
#13
Lukas Streese, Arne Deiseroth, Juliane Schäfer, Arno Schmidt-Trucksäss, Henner Hanssen
Background: Age is a key determinant for the development of cardiovascular disease and higher age coincides with an increased prevalence of obesity and physical inactivity. The study examines the influence of physical activity on aging processes of physiological systems focusing on the mechanisms of vascular aging. Methods/Design: The study consists of two parts. The cross-sectional approach aims at examining the association of physical fitness and cardiovascular risk with large and small artery function in healthy older active (HOA, n = 40) and sedentary (HOS, n = 40) persons as well as older sedentary individuals with increased cardiovascular risk (OSR, n = 80) aged 50-80 years...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29512306/preventing-muscle-wasting-by-osteoporosis-drug-alendronate-in-vitro-and-in-myopathy-models-via-sirtuin-3-down-regulation
#14
Hsien-Chun Chiu, Chen-Yuan Chiu, Rong-Sen Yang, Ding-Cheng Chan, Shing-Hwa Liu, Chih-Kang Chiang
BACKGROUND: A global consensus on the loss of skeletal muscle mass and function in humans refers as sarcopenia and cachexia including diabetes, obesity, renal failure, and osteoporosis. Despite a current improvement of sarcopenia or cachexia with exercise training and supportive therapies, alternative and specific managements are needed to discover for whom are unable or unwilling to embark on these treatments. Alendronate is a widely used drug for osteoporosis in the elderly and postmenopausal women...
March 6, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29499084/physical-activity-diet-and-other-behavioural-interventions-for-improving-cognition-and-school-achievement-in-children-and-adolescents-with-obesity-or-overweight
#15
REVIEW
Anne Martin, Josephine N Booth, Yvonne Laird, John Sproule, John J Reilly, David H Saunders
BACKGROUND: The global prevalence of childhood and adolescent obesity is high. Lifestyle changes towards a healthy diet, increased physical activity and reduced sedentary activities are recommended to prevent and treat obesity. Evidence suggests that changing these health behaviours can benefit cognitive function and school achievement in children and adolescents in general. There are various theoretical mechanisms that suggest that children and adolescents with excessive body fat may benefit particularly from these interventions...
March 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29482662/bright-light-therapy-versus-physical-exercise-to-prevent-co-morbid-depression-and-obesity-in-adolescents-and-young-adults-with-attention-deficit-hyperactivity-disorder-study-protocol-for-a-randomized-controlled-trial
#16
Jutta S Mayer, Katharina Hees, Juliane Medda, Oliver Grimm, Philip Asherson, Mariano Bellina, Michael Colla, Pol Ibáñez, Elena Koch, Antonio Martinez-Nicolas, Adrià Muntaner-Mas, Anna Rommel, Nanda Rommelse, Saskia de Ruiter, Ulrich W Ebner-Priemer, Meinhard Kieser, Francisco B Ortega, Johannes Thome, Jan K Buitelaar, Jonna Kuntsi, J Antoni Ramos-Quiroga, Andreas Reif, Christine M Freitag
BACKGROUND: The risk for major depression and obesity is increased in adolescents and adults with attention-deficit / hyperactivity disorder (ADHD) and adolescent ADHD predicts adult depression and obesity. Non-pharmacological interventions to treat and prevent these co-morbidities are urgently needed. Bright light therapy (BLT) improves day-night rhythm and is an emerging therapy for major depression. Exercise intervention (EI) reduces obesity and improves depressive symptoms. To date, no randomized controlled trial (RCT) has been performed to establish feasibility and efficacy of these interventions targeting the prevention of co-morbid depression and obesity in ADHD...
February 26, 2018: Trials
https://www.readbyqxmd.com/read/29481969/real-world-safety-and-efficacy-of-fluid-filled-dual-intra-gastric-balloon-for-weight-loss
#17
Abhishek Agnihotri, Amy Xie, Christopher Bartalos, Vladimir Kushnir, Sameer Islam, Ebtesam Islam, Mark Lamet, Ari Lamet, Ramin Farboudmanesch, Bergein F Overholt, Johnny Altawil, Dayna S Early, Michael Bennett, Abigail Lowe, Daniel K Mullady, Christine Sade Adeyeri, Mohamad El Zein, Priya Mishra, Lea Fayad, Margo Dunlap, Andreas Oberbach, Lawrence J Cheskin, Anthony N Kalloo, Mouen A Khashab, Vivek Kumbhari
BACKGROUND & AIMS: Reshape Duo is a saline-filled dual, integrated intra-gastric balloon (IGB) approved by the Food and Drug Administration for weight loss in patients with obesity. In a prospective, randomized trial, obese patients who received the balloon had significantly greater percent excess weight loss (%EWL) compared with patients treated with diet and exercise alone. However, there are limited data on the real-world efficacy of the Reshape balloon. METHODS: We performed a retrospective study of data collected from 2 academic centers and 5 private practices in which all patients paid for the IGB and follow-up visits out of pocket...
March 2, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29473115/the-effects-of-exercise-training-associated-with-low-level-laser-therapy-on-biomarkers-of-adipose-tissue-transdifferentiation-in-obese-women
#18
Raquel Munhoz da Silveira Campos, Ana Raimunda Dâmaso, Deborah Cristina Landi Masquio, Fernanda Oliveira Duarte, Marcela Sene-Fiorese, Antonio Eduardo Aquino, Filippo Aragão Savioli, Pamela Cristina Lopes Quintiliano, Ana Claudia Pelissari Kravchychyn, Liliane Isabel Guimarães, Lian Tock, Lila Missae Oyama, Valter Tadeu Boldarine, Vanderlei Salvador Bagnato, Nivaldo Antonio Parizotto
Investigations suggest the benefits of low-level laser therapy (LLLT) to improve noninvasive body contouring treatments, inflammation, insulin resistance and to reduce body fat. However, the mechanism for such potential effects in association with exercise training (ET) and possible implications in browning adiposity processes remains unclear. Forty-nine obese women were involved, aged between 20 and 40 years with a body mass index (BMI) of 30-40 kg/m2 . The volunteers were divided into Phototherapy (808 nm) and SHAM groups...
February 23, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29432326/exercise-improves-physical-activity-and-comorbidities-in-obese-adults-with-asthma
#19
Patrícia Duarte Freitas, Aline Grandi Silva, Palmira Gabriele Ferreira, Analuci da Silva, João Marcos Salge, Regina Maria Carvalho-Pinto, Alberto Cukier, Claudia M Brito, Marcio C Mancini, Celso R F Carvalho
INTRODUCTION: Obese adults with asthma have an increased number of comorbidities and reduced daily life physical activity (DLPA), which may worsen asthma symptoms. Exercise is recommended to improve asthma outcomes; however, the benefits of exercise for psychosocial comorbidities and physical activity levels in obese adults with asthma have been poorly investigated. OBJECTIVE: To assess the effects of exercise on DLPA, asthma symptoms and psychosocial comorbidities in obese adults with asthma...
February 9, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29428927/dancing-for-healthy-aging-functional-and-metabolic-perspectives
#20
Josianne Rodrigues-Krause, Mauricio Krause, Alvaro Reischak-Oliveira
Context • Dancing has been used as a form of exercise to improve functional and metabolic outcomes during aging. The field lacks randomized, clinical trials (RCTs) evaluating metabolic outcomes related to dance interventions, but dancing may be a form of exercise that could induce positive effects on the metabolic health of older adults. However, primary studies seem very heterogonous regarding the trial designs, characteristics of the interventions, the methods for outcomes assessments, statistical powers, and methodological quality...
February 10, 2018: Alternative Therapies in Health and Medicine
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