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Exercise therapy obesity

Patricia D Freitas, Palmira G Ferreira, Aline G Silva, Rafael Stelmach, Regina M Carvalho-Pinto, Frederico L A Fernandes, Marcio C Mancini, Maria N Sato, Milton A Martins, Celso R F Carvalho
RATIONALE: Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight-loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated. OBJECTIVE: To examine the effect of exercise training in a weight-loss program on asthma control, quality of life, inflammatory biomarkers and lung function. METHODS: Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program + exercise (WL+E group, n=28) or a weight-loss program + sham (WL+S group, n=27) group, where the weight-loss program included nutrition (caloric restriction) and psychological therapies...
July 19, 2016: American Journal of Respiratory and Critical Care Medicine
Trinath Kumar Mishra, Biswajit Das
BACKGROUND: Coronary artery disease (CAD) is rising in epidemic proportions with India not being an exception. CAD in Indian scenario has its onset at a younger age with multitude of risk factors. OBJECTIVE: This study was carried out to obtain complete information about demographic profile, risk factors, clinical scenario, therapeutic modalities, natural course, outcome and changing profile of acute ST-segment elevated myocardial infarction (STEMI) patients. METHODS: This cross-sectional study was conducted in 45,122 acute STEMI patients admitted 1st March 1990 to 1st March 2014...
June 2016: Journal of the Association of Physicians of India
Joseph A Ladapo, Udo Hoffmann, Kerry L Lee, Adrian Coles, Megan Huang, Daniel B Mark, Rowena J Dolor, Robert A Pelberg, Matthew Budoff, Gardar Sigurdsson, Harry W Severance, Pamela S Douglas
BACKGROUND: Diagnostic testing in the care of patients newly presenting with symptoms suggestive of coronary artery disease may influence risk factor management, independent of test type or test results. However, little is known about changes in medications and lifestyle after anatomical or functional testing. METHODS AND RESULTS: We examined what factors influenced preventive medical therapy and lifestyle practices at 60 days among 10 003 symptomatic patients (53% women; mean age 61 years) randomly assigned to anatomical testing with coronary computed tomographic angiography or functional testing (NCT01174550)...
October 12, 2016: Journal of the American Heart Association
Jesús Millán, Juan Pedro-Botet, Elisenda Climent, Joaquín Millán, Joan Rius
BACKGROUND AND OBJECTIVE: Muscle symptoms, with or without elevation of creatin kinase are one of the main adverse effects of statin therapy, a fact that sometimes limits their use. The aim of this study was to evaluate the clinical characteristics of patients treated with statins who have complained muscle symptoms and to identify possible predictive factors. PATIENTS AND METHODS: A cross-sectional one-visit, non-interventional, national multicenter study including patients of both sexes over 18 years of age referred for past or present muscle symptoms associated with statin therapy was conducted...
October 4, 2016: Clínica e Investigación en Arteriosclerosis
Andrea Figura, Matthias Rose, Jürgen Ordemann, Burghard F Klapp, Anne Ahnis
BACKGROUND: Patients with severe obesity need to adapt to surgically induced changes in their eating behaviors to maintain treatment success. OBJECTIVES: This study examined the effects of laparoscopic sleeve gastrectomy (LSG) on weight loss and on 3 dimensions of eating behavior, namely, cognitive restraint, disinhibition, and hunger. Outcomes of the LSG group were compared with a group of conservatively treated (CT) patients, who underwent a 1-year multimodal weight-reduction group program that included dietary advice, physical exercise, psychoeducation, cognitive-behavioral therapy, training in Jacobson's progressive muscle relaxation, and social group support...
August 5, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Nassia Kioukia-Fougia, Nikolaos Georgiadis, Konstantinos Tsarouhas, Fotini Vasilaki, Persefoni Fragiadaki, Evangelia Meimeti, Christina Tsitsimpikou
BACKGROUND: The modern way of life involves high stress levels, poor eating habits, lack of exercise, obesity and other detrimental health factors. Nutritional supplements (NS) are complexes of nutrients with variant activity that may infer reversal to nutrient depletion. They tend to be popular amongst social categories associated with the healthy life style, such as the elite and amateur athletes, military people and the general population. OBJECTIVE: An overview of the state of play with regards to nutritional supplements -natural and synthetic-, is important both from toxicological and commercial point of view...
September 23, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Alexandre Abilio de Souza Teixeira, Fábio Santos Lira, Gustavo D Pimentel, Camila Oliveira de Souza, Helena Batatinha, Luana A Biondo, Alex S Yamashita, Edson A Lima Junior, José Cesar Rosa Neto
White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances...
2016: Critical Reviews in Eukaryotic Gene Expression
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
John A Batsis, Lydia E Gill, Rebecca K Masutani, Anna M Adachi-Mejia, Heather B Blunt, Pamela J Bagley, Francisco Lopez-Jimenez, Stephen J Bartels
OBJECTIVES: To identify geriatric obesity interventions that can guide clinical recommendations. DESIGN: Systematic review using Medline (PubMed), Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, EMBASE (Ovid), and PsycINFO (Proquest) from January 1, 2005, to October 12, 2015, to identify English-language randomized controlled trials. PARTICIPANTS: Individuals aged 60 and older (mean age ≥65) and classified as having obesity (body mass index ≥30 kg/m(2) )...
September 19, 2016: Journal of the American Geriatrics Society
Vanessa Fadanelli Schoenardie Poli, Ricardo Badan Sanches, Amanda Dos Santos Moraes, João Pedro Novo Fidalgo, Maythe Amaral Nascimento, Stephan Garcia Andrade-Silva, José Carlos Clemente, Liu Chiao Yi, Danielle Arisa Caranti
Assessing energy requirements is a fundamental activity in clinical dietetic practice. The aim of this study was to investigate which resting energy expenditure (REE) predictive equations are the best alternatives to indirect calorimetry before and after an interdisciplinary therapy in Brazilian obese women. In all, twelve equations based on weight, height, sex, age, fat-free mass and fat mass were tested. REE was measured by indirect calorimetry. The interdisciplinary therapy consisted of nutritional, physical exercise, psychological and physiotherapy support during the course of 1 year...
October 2016: British Journal of Nutrition
Hans-Theo Schon, Ralf Weiskirchen
Chronic liver disease (CLD) features constant parenchymal injury and repair together with an increasing hepatic impairment, finally leading to fibrosis and cirrhosis and a heightened risk of hepatocellular carcinoma (HCC). Closely related to the rise in obesity, the worldwide prevalence of nonalcoholic fatty liver disease, the most common form of CLD, has reached an epidemic dimension and is estimated to afflict up to 46% of the general population, including more than one out of three U.S. citizens. Up to now there is no effective drug treatment available, which is why recommendations encompass both exercise programs and changes in dietary habits...
2016: Frontiers in Pharmacology
Emilian Rejane Marcon, S Baglioni, L Bittencourt, C L N Lopes, C R Neumann, M R M Trindade
OBJECTIVE: This trial's objective was to investigate the effect of an exercise program with and without cognitive-behavioral therapy (CBT), compared by a control group, on weight, functional capacity, and cardiometabolic profile of morbidly obese individuals while waiting for bariatric surgery. MATERIALS AND METHODS: This randomized controlled trial investigated the effect of a 4-month low-intensity exercise program (two weekly sessions of 25 min each) on 66 morbidly obese individuals awaiting bariatric surgery...
September 13, 2016: Obesity Surgery
Ronan Thibault, Claude Pichard
PURPOSE OF REVIEW: In the context of the worldwide obesity epidemic, bariatric surgery is the only therapy associated with a sustainable weight loss and to midterm prevention of obesity-related complications. However, nutritional and behavioral multidisciplinary medical preparation, as well as long-term postoperative nutritional follow-up, is strongly advised to avoid postoperative surgical, nutritional, or psychiatric complications. RECENT FINDINGS: Due to a long history of restrictive diets and large body weight fluctuations, preoperative nutritional assessment and correction of vitamin and trace elements deficiencies are mandatory...
November 2016: Current Opinion in Clinical Nutrition and Metabolic Care
Christine Petrin, Scott Kahan, Monique Turner, Christine Gallagher, William H Dietz
INTRODUCTION: Relatively few patients receive obesity counselling consistent with the USPSTF guidelines, and many health care professionals (HCPs) are biased in their attitudes towards obesity management. METHODS: A national sample of family physicians, internists, OB/GYN physicians, and nurse practitioners (NPs) completed a web-based survey of beliefs, practice, and knowledge regarding obesity management. RESULTS: A majority of HCPs believe that it is both the patient's and the provider's responsibility to ensure that the patient is counselled about obesity...
August 25, 2016: Obesity Research & Clinical Practice
Mariëtte de Rooij, Marike van der Leeden, John Cheung, Martin van der Esch, Arja Häkkinen, Daniël Haverkamp, Leo D Roorda, Jos Twisk, Joke Vollebregt, Willem F Lems, Joost Dekker
OBJECTIVE: To evaluate the efficacy on physical functioning and safety of tailored exercise therapy in patients with knee osteoarthritis (KOA) and comorbidities. METHOD: In a randomized controlled trial, 126 participants were included with a clinical diagnosis of KOA and at least one of the following target comorbidities: coronary disease, heart failure, type 2 diabetes, chronic obstructive pulmonary disease or obesity (body mass index≥ 30kg/m(2) ), with severity score ≥2 on the Cumulative Illness Rating Scale...
August 26, 2016: Arthritis Care & Research
Gabriela Gutiérrez-Salmeán, Eduardo Meaney, Miguel A Lanaspa, Christina Cicerchi, Richard J Johnson, Sundeep Dugar, Pam Taub, Israel Ramírez-Sánchez, Francisco Villarreal, George Schreiner, Guillermo Ceballos
BACKGROUND: Cardiometabolic disruptions such as insulin resistance, obesity, high blood pressure, hyperglycemia, and dyslipidemias, are known to increase the risk for cardiovascular and metabolic diseases such as type 2 diabetes mellitus and atherosclerosis. Several screening tools for assessing cardiometabolic risk have been developed including the TG/HDLc ratio, which has been, demonstrated to possess a strong association with insulin resistance and coronary disease. Dietary modifications, together with regular moderate exercise have proven to be effective in attenuating cardiometabolic disruptions...
November 15, 2016: International Journal of Cardiology
Per Lundkvist, C David Sjöström, Sam Amini, Maria J Pereira, Eva Johnsson, Jan W Eriksson
AIMS: Dapagliflozin as well as exenatide reduce bodyweight in patients with type 2 diabetes. We explored the effects of dual therapy with these agents on bodyweight, body composition, glycemic parameters, and systolic blood pressure (SBP) in obese nondiabetic adults. MATERIALS AND METHODS: This single-center, double-blind trial randomized 50 obese nondiabetic adults (aged 18-70 years; body mass index 30-45 kg/m(2) ) to oral dapagliflozin 10 mg once daily plus subcutaneous long-acting exenatide 2 mg once weekly or placebo...
August 23, 2016: Diabetes, Obesity & Metabolism
J Mendiola-Precoma, L C Berumen, K Padilla, G Garcia-Alcocer
Alzheimer's disease (AD) is the most common cause of dementia associated with a progressive neurodegenerative disorder, with a prevalence of 44 million people throughout the world in 2015, and this figure is estimated to double by 2050. This disease is characterized by blood-brain barrier disruption, oxidative stress, mitochondrial impairment, neuroinflammation, and hypometabolism; it is related to amyloid-β peptide accumulation and tau hyperphosphorylation as well as a decrease in acetylcholine levels and a reduction of cerebral blood flow...
2016: BioMed Research International
Michael D George, Neilia-Kay McGill, Joshua F Baker
BACKGROUND: Creatine kinase (CK) values are a critical part of the workup of suspected myopathies and are often assessed in patients that develop myalgia on statin therapy. CK elevations may influence the initiation and cessation of statin treatment, and incidentally discovered CK elevation may lead to further testing. A number of factors influence CK levels in healthy patients, but current reference ranges do not incorporate important influencers of CK such as race. Objectives of this study were to evaluate clinical factors associated with CK among healthy individuals and to develop practical reference ranges for important subgroups to improve test interpretation...
August 2016: Medicine (Baltimore)
J L Cameron, R Jain, M Rais, A E White, T M Beer, P Kievit, K Winters-Stone, I Messaoudi, O Varlamov
BACKGROUND/OBJECTIVES: Androgen deprivation therapy (ADT) is commonly used for treatment of prostate cancer, but is associated with side effects such as sarcopenia and insulin resistance. The role of lifestyle factors such as diet and exercise on insulin sensitivity and body composition in testosterone-deficient males is poorly understood. The aim of the present study was to examine the relationships between androgen status, diet, and insulin sensitivity. SUBJECTS/METHODS: Middle-aged (11-12-yo) intact and orchidectomized male rhesus macaques were maintained for two months on a standard chow diet, and then exposed for six months to a Western-style, high-fat/calorie-dense diet (WSD) followed by four months of caloric restriction (CR)...
August 18, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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