Maria Alejandra Garcia-Marquez, Martin Thelen, Eugen Bauer, Lukas Maas, Kerstin Wennhold, Jonas Lehmann, Diandra Keller, Miloš Nikolić, Julie George, Thomas Zander, Wolfgang Schröder, Philipp Müller, Ali M Yazbeck, Christiane Bruns, Roman Thomas, Birgit Gathof, Alexander Quaas, Martin Peifer, Axel M Hillmer, Michael von Bergwelt-Baildon, Hans Anton Schlößer
BACKGROUND: The individual HLA-I genotype is associated with cancer, autoimmune diseases and infections. This study elucidates the role of germline homozygosity or allelic imbalance of HLA-I loci in esophago-gastric adenocarcinoma (EGA) and determines the resulting repertoires of potentially immunogenic peptides. METHODS: HLA genotypes and sequences of either (1) 10 relevant tumor-associated antigens (TAAs) or (2) patient-specific mutation-associated neoantigens (MANAs) were used to predict good-affinity binders using an in silico approach for MHC-binding (www...
April 17, 2024: Journal for Immunotherapy of Cancer