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https://www.readbyqxmd.com/read/28550786/two-giant-peritoneal-loose-bodies-were-simultaneously-found-in-one-patient-a-case-report-and-review-of-the-literature
#1
Qingxing Huang, Aihong Cao, Jun Ma, Zhenhua Wang, Jianhong Dong
INTRODUCTION: Peritoneal loose body(PLB) is usually small, therefore giant Peritoneal loose body(gPLB) with a diameter >5cm has rarely been described in the literatures. We report a case of two gPLB simultaneously found in one patient. PRESENTATION OF CASE: A healthy 79-year-old man palpated himself a solid mass with alternating localizations in his peritoneal cavity 6 months ago. It was not the complaint of frequency of urinatior until he saw the doctor a week ago...
May 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28550732/reversing-the-polarization-of-tumor-associated-macrophages-inhibits-tumor-metastasis
#2
Rufei Yuan, Shengfu Li, Hua Geng, Xin Wang, Qinglin Guan, Xiaohuan Li, Changle Ren, Xiaolin Yuan
OBJECTIVE: The M2 phenotype is dominant in tumor associated macrophages (TAM), and plays a key role in promoting tumor growth, invasion and metastasis. Converting TAM polarization from M2 to M1 may contribute to eliciting anti-tumor-specific immune responses and inhibiting tumor metastasis. In this study, the effect of reversing the polarization of TAM on tumor metastasis was investigated. METHODS: Peritoneal macrophages were obtained from BABL/c mice, and M2 polarization was induced by IL-4...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28550391/gut-liver-axis-cirrhosis-and-portal-hypertension-the-chicken-and-the-egg
#3
Juan P Arab, Rosa M Martin-Mateos, Vijay H Shah
The term gut-liver axis is used to highlight the close anatomical and functional relationship between the intestine and the liver. The intestine has a highly specialized epithelial membrane which regulates transport across the mucosa. Due to dysbiosis, impairment of the intestinal barrier and altered immunity status, bacterial products can reach the liver through the portal vein, where they are recognized by specific receptors, activate the immune system and lead to a proinflammatory response. Gut microbiota and bacterial translocation play an important role in the pathogenesis of chronic liver diseases, including alcoholic and non-alcoholic fatty liver disease, cirrhosis, and its complications, such as portal hypertension, spontaneous bacterial peritonitis and hepatic encephalopaty...
May 26, 2017: Hepatology International
https://www.readbyqxmd.com/read/28549976/brca-mutational-status-initial-disease-presentation-and-clinical-outcome-in-high-grade-serous-advanced-ovarian-cancer-a-multicenter-study
#4
Marco Petrillo, Claudia Marchetti, Rossella De Leo, Angela Musella, Ettore Capoluongo, Ida Paris, Pierluigi Benedetti Panici, Giovanni Scambia, Anna Fagotti
BACKGROUND: In the last decades, several efforts have been done to clarify the role of BRCA mutational status in women with advanced ovarian cancer demonstrating its role in cancer development, as well as the prognostic significance of BRCA genotype. OBJCTIVE: Our aim is to evaluate the correlation between BRCA mutational status and disease presentation in a large series of advanced high-grade serous ovarian cancer patients. STUDY DESIGN: this is a retrospective multicenter study including a consecutive series of newly diagnosed high-grade serous ovarian cancer patients with FIGO Stage IIIC-IV disease, at least 18 months of follow-up time, tested for BRCA 1/2 germline mutation status...
May 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28549942/tissue-specific-expression-profile-of-some-immune-related-genes-in-labeo-rohita-to-edwardsiella-tarda-infection
#5
Sajal Kole, Deepika Anand, Rupam Sharma, Gayatri Tripathi, Makesh M, Rajendran Kv, Megha Kadam Bedekar
Rohu (Labeo rohita), an Indian Major Carp (IMC) is an economically important aquaculture species in India. Inspite of the technological advances, infectious diseases caused by viruses, bacteria and parasites have been a major limiting factor in the development and profitability of fish farms. At present, information regarding the immune status of the Indian major carps is limited. This lack of knowledge is a major impediment for establishment of effective preventive measures against broad spectrum of infectious agents...
May 23, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28549897/daily-acute-intermittent-hypoxia-improves-breathing-function-with-acute-and-chronic-spinal-injury-via-distinct-mechanisms
#6
B J Dougherty, J Terada, S R Springborn, S Vinit, P M MacFarlane, G S Mitchell
Daily acute intermittent hypoxia (dAIH) elicits respiratory plasticity, enhancing respiratory motor output and restoring breathing capacity after incomplete cervical spinal injuries (cSCI). We hypothesized that dAIH-induced functional recovery of breathing capacity would occur after both acute (2 weeks) and chronic (8 weeks) cSCI, but through distinct cellular mechanisms. Specifically, we hypothesized that dAIH-induced breathing recovery would occur through serotonin-independent mechanisms 2wks post C2 cervical hemisection (C2Hs), versus serotonin-dependent mechanisms 8wks post C2Hs...
May 23, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28549831/adenocarcinoma-of-the-appendix-with-extra-appendicular-spread-clinico-surgical-and-histologic-analysis-of-27-cases
#7
Francisco J Morera Ocón, Bruno Camps Vilata, Elena Muñoz Forner, Clara Navarro Campoy, Javier Gallego Plazas, Samuel Navarro Fos
BACKGROUND AND OBJECTIVES: Appendiceal neoplasms with extra-appendiceal spread may show different clinical patterns with pseudomyxoma peritonei (PMP) being one of them. We analyse the results in a series of patients treated in our centre. MATERIAL AND METHODS: Retrospective study of patients operated on for appendiceal peritoneal carcinomatosis from January 2012 to May 2015. RESULTS: Twenty-seven consecutive patients were included. Median age 63 years (26-73); 14 were men...
May 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28549290/anti-inflammatory-potential-of-hentriacontane-in-lps-stimulated-raw-264-7-cells-and-mice-model
#8
Vidushi Khajuria, Shilpa Gupta, Neha Sharma, Ashok Kumar, Nazir A Lone, Mowkshi Khullar, Prabhu Dutt, Parduman Raj Sharma, Asha Bhagat, Zabeer Ahmed
Hentriacontane, has various pharmacological effects including anti-inflammatory, antitumor and antimicrobial activities. Its anti-inflammatory potential has been demonstrated in peritoneal macrophages. However detailed studies on other models elucidating the mechanistic description of the mode of action has not been done. Hence, the aim of the present study is to evaluate the anti-inflammatory potential of hentriacontane both in-vivo (Balb/c mice) and in-vitro (RAW 264.7 cells). Cytokine inhibition of both pro-inflammatory (TNF-α, IL-6, MCP-1 and IL-1β) and anti-inflammatory (IL-10) cytokines was studied in RAW 264...
May 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28549261/small-spontaneously-ruptured-gastrointestinal-stromal-tumor-in-the-small-intestine-causing-hemoperitoneum-a-case-report
#9
Shuichi Fukuda, Yoshinori Fujiwara, Tomoko Wakasa, Keisuke Inoue, Kotaro Kitani, Hajime Ishikawa, Masanori Tsujie, Masao Yukawa, Yoshio Ohta, Masatoshi Inoue
INTRODUCTION: Gastrointestinal stromal tumors (GISTs) are clinically asymptomatic until they reach a significant size; therefore, GISTs that are 2cm or less are typically asymptomatic. Patients with symptomatic GISTs typically present with abdominal pain, gastrointestinal bleeding, or a palpable mass but rarely present with hemoperitoneum. PRESENTATION OF CASE: A 72-year-old Japanese man presented to us with acute onset abdominal pain. Physical examination showed peritoneal irritation in the lower abdomen...
May 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28548958/interleukin-6-174g-c-gene-promoter-polymorphism-and-prognosis-in-patients-with-cancer
#10
Kan Zhai, Yong Yang, Zhi-Gang Gao, Jie Ding
Interleukin-6 (IL-6) is known to be involved in the pathogenesis of cancer progression. IL-6-174G>C polymorphism has shown several results in association studies. In this study, we evaluated the association the IL-6-174G>C polymorphism and overall survival (OS) of cancer using 17 eligible studies with 4,304 patients. Our meta-analysis indicated that IL-6-174G>C polymorphism is not associated with OS when assessed using 3 genotype comparison including GG/(GC+CC), CC/(GC+GG) and CC/GG. Interestingly, compared to GG carrier, patients with IL-6-174GC genotype showed a decreased hazard of poor OS (hazard ratio = 0...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548905/brca-associated-cancers-role-of-imaging-in-screening-diagnosis-and-management
#11
Michelle V Lee, Venkata S Katabathina, Michyla L Bowerson, Marina I Mityul, Anup S Shetty, Khaled M Elsayes, Aparna Balachandran, Priya R Bhosale, Ann E McCullough, Christine O Menias
Harmful mutations of the BRCA tumor suppressor genes result in a greater lifetime risk for malignancy-breast and ovarian cancers in particular. An increased risk for male breast, fallopian tube, primary peritoneal, pancreatic, prostate, and colon cancers also has been reported. The BRCA gene is inherited in an autosomal dominant pattern and tends to be highly penetrant; thus, there is an increased incidence of these cancers in affected families. Compared with sporadic tumors, BRCA-associated malignancies have unique manifestations, clinical features, and pathologic profiles...
May 26, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28548570/embolic-mycotic-encephalitis-in-a-cow-following-mortierella-wolfii-infection-of-a-surgery-site
#12
Benjamin Curtis, Charlotte Hollinger, Ailam Lim, Matti Kiupel
A 5-y-old Holstein dairy cow had surgery for a suspected displaced abomasum 10 d postpartum, developed acute neurologic signs at day 19, and was found dead 21 d postpartum. At autopsy, there was a peri-incisional intramuscular abscess that communicated with the peritoneal cavity, as well as hemorrhage and malacia involving the brain, and multiple nodules in the liver, kidneys, and lungs. Fungal hyphae were seen histologically at the surgery site, on the surface of the liver, and in lesions of severe necrotizing vasculitis in the lungs, kidneys, brain, and liver...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28548231/combination-therapy-with-telmisartan-and-parecoxib-induces-regression-of-endometriotic-lesions
#13
Anca Nenicu, Yuan Gu, Christina Körbel, Michael D Menger, Matthias W Laschke
BACKGROUND AND PURPOSE: Telmisartan suppresses the development of endometriotic lesions. However, the drug also up-regulates the expression of cyclooxygenase (COX)-2, which has been suggested to promote the progression of endometriosis. Accordingly, we herein analysed whether a combination therapy with telmisartan and a COX-2 inhibitor may be more effective in the treatment of endometriotic lesions than application of telmisartan alone. EXPERIMENTAL APPROACH: Endometriotic lesions were induced in the peritoneal cavity of C57BL/6 mice, which were daily treated with an intraperitoneal (i...
May 26, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28548199/-acute-small-bowel-diverticulitis-in-a-patient-with-crohn%C3%A2-s-disease
#14
Macarena Hevia, Rodrigo Quera, Leonardo Soto, Tomás Regueira, Andrés O'Brien, Andrés Larach, Udo Kronberg
Diverticular disease of the small intestine is rare, especially when it is located in the jejunum. It is generally asymptomatic, but in some patients it may have complications such as acute diverticulitis with peritonitis, gastrointestinal bleeding or obstruction. In such cases, the recommended treatment is surgery. We report a 77-year-old patient with ileal Crohn’s disease with a long-standing inflammatory phenotype, who developed acute diverticulitis of the jejunum presenting a severe septic shock and secondary multiple-organ failure...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28547932/from-intraperitoneal-onlay-mesh-repair-to-preperitoneal-onlay-mesh-repair
#15
REVIEW
George Pei Cheung Yang
Laparoscopic repair for ventral and incisional hernias was first reported in the early 1990s. It uses intraperitoneal only mesh placement to achieve a tension-free repair of the hernia. However, in recent years, there has been greater concern about long-term complication involving intraperitoneal mesh placement. Many case reports and case series have found evidence of mesh adhesion, mesh fistulation, and mesh migration into hollow organs including the esophagus, small bowel, and large bowel, resulting in various major acute abdominal events...
May 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28547631/management-of-diverticulitis-in-2017
#16
Sarah E Deery, Richard A Hodin
Diverticulitis has become increasingly more common in the 20(th) century and is now one of the most frequent indications for gastrointestinal tract-related hospitalizations. The spectrum of clinical presentation can vary widely from mild, uncomplicated disease that can be managed as an outpatient, to complicated diverticulitis with peritonitis and sepsis. Historically, all patients with diverticulitis were managed with, at a minimum, a course of antibiotics, with many patients undergoing urgent or emergent surgery with a sigmoid colectomy, end colostomy, and oversewn rectosigmoid "Hartmann's" stump...
May 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28546813/a-case-of-urachal-carcinoma-of-the-abdominal-wall-in-a-kidney-transplant-recipient
#17
Takuya Yamazaki, Yasushi Nagaba, Yoshitaka Shimada, Yoshinori Taoka, Satoru Minamida, Dai Koguchi, Masahiro Hagiwara, Sho Watanuki, Hide Nagaba, Kazunari Yoshida, Yasuo Takeuchi
Urachal carcinoma is an extremely rare malignant tumor arising from the urachus in the fetus. We report a patient who developed urachal carcinoma 18 years after kidney transplantation. A 59-year-old man was admitted because of abdominal pain and massive ascites. He had undergone kidney transplantation 18 years earlier and had end-stage renal disease requiring dialysis. Abdominal CT showed massive ascites and an abdominal wall cystic mass separated from the peritoneal cavity. Hemodialysis was started, and paralytic ileus was diagnosed and treated...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28546700/advanced-primary-epithelial-ovarian-and-peritoneal-carcinoma-does-diagnostic-accuracy-of-preoperative-ct-scan-for-detection-of-peritoneal-metastatic-sites-reflect-into-prediction-of-suboptimal-debulking-a-prospective-study
#18
Kiran Bagul, D K Vijaykumar, Anupama Rajanbabu, Mitchelle Aline Antony, Venkatesan Ranganathan
Ovarian cancer is the seventh most common cancer in females worldwide. Optimal debulking is the standard treatment but possible only in 30-85% of advanced stages. Knowing exactly the disease extent preoperatively may predict suboptimal debulking. We analyzed diagnostic accuracy of preoperative CT scan in disease mapping and prediction of suboptimal debulking in a prospective observational study from March 2013 to May 2015 in a tertiary hospital. Adults below the age of 75 years with ECOG PS-0, 1, 2, clinically/radiologically newly diagnosed stage IIIc epithelial ovarian (EOC), and primary peritoneal carcinoma (PPC) were included...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28546369/the-utility-of-sonographic-assessment-in-selecting-patients-for-percutaneous-insertion-of-peritoneal-dialysis-catheter
#19
Renuka Shanmugalingam, Angela Makris, Hicham Hassan, Yan Li, Imelda DeGuzman, Hareeshan Nandakoban, Ananthakrishnapuram Aravindan, Govind Narayanan, Jeffrey Wong
♦Background: Percutaneous insertion of peritoneal dialysis (PD) catheters by nephrologists is a safe and effective alternative to open surgical techniques. These patients are usually carefully selected due to anatomical considerations and medical comorbidities, with the current literature suggesting exclusion of patients with prior abdominal surgery. ♦ Method: We conducted a retrospective cohort study of pre-dialysis patients who attended a preprocedural clinic in a tertiary center over 6 years. Procedural complications and catheter survival were assessed...
May 25, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28546368/effects-of-a-comprehensive-predialysis-education-program-on-the-home-dialysis-therapies-a-retrospective-cohort-study
#20
Ashutosh Shukla, Andrea K Easom, Manisha Singh, Richa Pandey, Dumitru Rotaru, Xuerong Wen, Sudhir V Shah
♦Background: Improvement in the rates of home dialysis has been a desirable but difficult-to-achieve target for United States nephrology. Provision of comprehensive predialysis education (CPE) in institutes with established home dialysis programs has been shown to facilitate a higher home dialysis choice amongst chronic kidney disease (CKD) patients. Unfortunately, limited data have shown the efficacy of such programs in the United States or in institutes with small home dialysis (HoD) programs. ♦ Methods: We report the retrospective findings examining the efficacy of a CPE program in the early period after its establishment, with reference to its impact on the choice and growth of a small HoD program...
May 25, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
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