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https://www.readbyqxmd.com/read/29651419/management-of-glioblastoma-multiforme-in-a-patient-treated-with-ketogenic-metabolic-therapy-and-modified-standard-of-care-a-24-month-follow-up
#1
Ahmed M A Elsakka, Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, Thomas N Seyfried
Few advances have been made in overall survival for glioblastoma multiforme (GBM) in more than 40 years. Here, we report the case of a 38-year-old man who presented with chronic headache, nausea, and vomiting accompanied by left partial motor seizures and upper left limb weakness. Enhanced brain magnetic resonance imaging revealed a solid cystic lesion in the right partial space suggesting GBM. Serum testing revealed vitamin D deficiency and elevated levels of insulin and triglycerides. Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29618993/categorizing-two-taiwanese-major-political-parties-from-their-faces-the-influence-of-provincial-appearance
#2
Chien-Kai Chang, Mary Wen-Reng Ho, Sarina Hui-Lin Chien
People go beyond the inferences afforded by a person's observable features to make guesses about personality traits or even social memberships such as political affiliations. The present study extended Hu et al. (2016) to further investigate the influence of provincial appearance on differentiating KMT (Kuomintang) and DPP (Democratic Progressive Party) candidates by headshot photos with three experiments. In Experiment 1 (Membership categorization task), participants categorized the photos from the pilot study (where the difference between the perceived age of KMT and DPP candidates was reduced) and divided into four blocks by their perceived age...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29552234/kinesin-5-mediated-chromosome-congression-in-insect-spindles
#3
Emily Tubman, Yungui He, Thomas S Hays, David J Odde
Introduction: The microtubule motor protein kinesin-5 is well known to establish the bipolar spindle by outward sliding of antiparallel interpolar microtubules. In yeast, kinesin-5 also facilitates chromosome alignment "congression" at the spindle equator by preferentially depolymerizing long kinetochore microtubules (kMTs). The motor protein kinesin-8 has also been linked to chromosome congression. Therefore, we sought to determine whether kinesin-5 or kinesin-8 facilitates chromosome congression in insect spindles...
February 2018: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29475948/antagonism-between-the-dynein-and-ndc80-complexes-at-kinetochores-controls-the-stability-of-kinetochore-microtubule-attachments-during-mitosis
#4
Mohammed A Amin, Richard J McKenney, Dileep Varma
Chromosome alignment and segregation during mitosis require kinetochore-microtubule (kMT) attachments that are mediated by the molecular motor dynein and the kMT-binding complex Ndc80. The Rod-ZW10-Zwilch (RZZ) complex is central to this coordination, as it has an important role in dynein recruitment and has recently been reported to have a key function in the regulation of stable kMT attachments in Caenorhabditis elegans, besides its role in activating the spindle assembly checkpoint (SAC). However, the mechanism by which these protein complexes control kMT attachments to drive chromosome motility during early mitosis is still unclear...
February 23, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29456496/how-do-acquired-political-identities-influence-our-neural-processing-toward-others-within-the-context-of-a-trust-game
#5
Chien-Te Wu, Yang-Teng Fan, Ye-Rong Du, Tien-Tun Yang, Ho-Ling Liu, Nai-Shing Yen, Shu-Heng Chen, Ray-May Hsung
Trust is essential for mutually beneficial human interactions in economic exchange and politics and people's social identities notably have dramatic effects on trust behaviors toward others. Previous literature concerning social identities generally suggests that people tend to show in-group favoritism toward members who share the same identity. However, how our brains process signals of identity while facing uncertain situations in interpersonal interactions remains largely unclear. To address this issue, we performed an fMRI experiment with 54 healthy adults who belonged to two identity groups of opposing political orientations...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29276005/histone-lysine-methylases-and-demethylases-in-the-landscape-of-human-developmental-disorders
#6
Víctor Faundes, William G Newman, Laura Bernardini, Natalie Canham, Jill Clayton-Smith, Bruno Dallapiccola, Sally J Davies, Michelle K Demos, Amy Goldman, Harinder Gill, Rachel Horton, Bronwyn Kerr, Dhavendra Kumar, Anna Lehman, Shane McKee, Jenny Morton, Michael J Parker, Julia Rankin, Lisa Robertson, I Karen Temple, Siddharth Banka
Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underpin gene regulation. Here we demonstrate that variants causing haploinsufficiency of KMTs and KDMs are frequently encountered in individuals with developmental disorders. Using a combination of human variation databases and existing animal models, we determine 22 KMTs and KDMs as additional candidates for dominantly inherited developmental disorders. We show that KMTs and KDMs that are associated with, or are candidates for, dominant developmental disorders tend to have a higher level of transcription, longer canonical transcripts, more interactors, and a higher number and more types of post-translational modifications than other KMT and KDMs...
January 4, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29170487/lysine-possesses-the-optimal-chain-length-for-histone-lysine-methyltransferase-catalysis
#7
Abbas H K Al Temimi, Y Vijayendar Reddy, Paul B White, Hong Guo, Ping Qian, Jasmin Mecinović
Histone lysine methyltransferases (KMTs) represent an important class of epigenetic enzymes that play essential roles in regulation of gene expression in humans. Members of the KMT family catalyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine residues in histone tails and core histones. Here we report combined MALDI-TOF MS experiments, NMR analyses and quantum mechanical/molecular dynamics studies on human KMT-catalyzed methylation of the most related shorter and longer lysine analogues, namely ornithine and homolysine, in model histone peptides...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29076964/lysine-methylation-signaling-in-pancreatic-cancer
#8
Gaël S Roth, Alexandre G Casanova, Nathanaël Lemonnier, Nicolas Reynoird
PURPOSE OF REVIEW: Despite better knowledge of its genetic basis, pancreatic cancer is still highly lethal with very few therapeutic options. In this review, we discuss the potential impact of epigenetic therapies, focusing on lysine methylation signaling and its implication in pancreatic cancer. RECENT FINDINGS: Protein lysine methylation, a key mechanism of posttranslational modifications of histone proteins, has emerged as a major cell signaling mechanism regulating physiologic and pathologic processes including cancer...
January 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28887308/uncovering-human-mettl12-as-a-mitochondrial-methyltransferase-that-modulates-citrate-synthase-activity-through-metabolite-sensitive-lysine-methylation
#9
Jędrzej Małecki, Magnus E Jakobsson, Angela Y Y Ho, Anders Moen, Arild C Rustan, Pål Ø Falnes
Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases (KMTs) remain largely elusive. Here, we investigated METTL12, a mitochondrial human S -adenosylmethionine (AdoMet)-dependent methyltransferase and found it to methylate a single protein in mitochondrial extracts, identified as citrate synthase (CS). Using several in vitro and in vivo approaches, we demonstrated that METTL12 methylates CS on Lys-395, which is localized in the CS active site...
October 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28830429/molecular-study-on-pasteurella-multocida-and-mannheimia-granulomatis-from-kenyan-camels-camelus-dromedarius
#10
Ilona V Gluecks, Astrid Bethe, Mario Younan, Christa Ewers
BACKGROUND: Outbreaks of a Haemorrhagic Septicaemia (HS) like disease causing large mortalities in camels (Camelus dromedarius) in Asia and in Africa have been reported since 1890. Yet the aetiology of this condition remains elusive. This study is the first to apply state of the art molecular methods to shed light on the nasopharyngeal carrier state of Pasteurellaceae in camels. The study focused on HS causing Pasteurella multocida capsular types B and E. Other Pasteurellaceae, implicated in common respiratory infections of animals, were also investigated...
August 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28760199/major-satellite-repeat-rna-stabilize-heterochromatin-retention-of-suv39h-enzymes-by-rna-nucleosome-association-and-rna-dna-hybrid-formation
#11
Oscar Velazquez Camacho, Carmen Galan, Kalina Swist-Rosowska, Reagan Ching, Michael Gamalinda, Fethullah Karabiber, Inti De La Rosa-Velazquez, Bettina Engist, Birgit Koschorz, Nicholas Shukeir, Megumi Onishi-Seebacher, Suzanne van de Nobelen, Thomas Jenuwein
The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity for major satellite repeat RNA. To analyze an RNA-dependent interaction with chromatin, we purified native nucleosomes from mouse ES cells and detect that Suv39h1 and Suv39h2 exclusively associate with poly-nucleosomes...
August 1, 2017: ELife
https://www.readbyqxmd.com/read/28690526/a-case-of-t-cell-lymphoma-treated-by-korean-medicine-therapy-alone
#12
Jun-Suk Jung, Dong-Hyun Lee, Shin Seong, Sung Su Kim
This case report is aimed to investigate the effects of Korean medicine therapy (KMT) alone including oral herbal medicine on treating a patient with atypical peripheral CD4 T cell lymphoma. The oral medicine used is Hyunamdan made of heat-processed ginseng and Hangamdan S. An 87-year-old man who was diagnosed as having atypical peripheral CD4 T cell lymphoma on November 30, 2015 was treated with KMT from December 23, 2015 until October 22, 2016. The effectiveness of therapies was evaluated with PET-CT scan as well as the change of the main sign of lymphoma...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28588028/the-lysine-methyltransferase-smyd2-methylates-the-kinase-domain-of-type-ii-receptor-bmpr2-and-stimulates-bone-morphogenetic-protein-signaling
#13
Shuman Gao, Zhiqiang Wang, Wencai Wang, Xueli Hu, Peilin Chen, Jiwen Li, Xinhua Feng, Jiemin Wong, James X Du
Lysine methylation of chromosomal and nuclear proteins is a well-known mechanism of epigenetic regulation, but relatively little is known about the role of this protein modification in signal transduction. Using an RNAi-based functional screening of the SMYD family of lysine methyltransferases (KMTs), we identified SMYD2 as a KMT essential for robust bone morphogenic protein (BMP)- but not TGFβ-induced target gene expression in HaCaT keratinocyte cells. A role for SMYD2 in BMP-induced gene expression was confirmed by shRNA knockdown and CRISPR/Cas9-mediated knock-out of SMYD2 We further demonstrate that SMYD2 knockdown or knock-out impairs BMP-induced phosphorylation of the signal-transducing protein SMAD1/5 and SMAD1/5 nuclear localization and interaction with SMAD4...
July 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28520920/methylation-of-human-eukaryotic-elongation-factor-alpha-eef1a-by-a-member-of-a-novel-protein-lysine-methyltransferase-family-modulates-mrna-translation
#14
Magnus E Jakobsson, Jedrzej Malecki, Benedikt S Nilges, Anders Moen, Sebastian A Leidel, Pål Ø Falnes
Many cellular proteins are methylated on lysine residues and this has been most intensively studied for histone proteins. Lysine methylations on non-histone proteins are also frequent, but in most cases the functional significance of the methylation event, as well as the identity of the responsible lysine (K) specific methyltransferase (KMT), remain unknown. Several recently discovered KMTs belong to the so-called seven-β-strand (7BS) class of MTases and we have here investigated an uncharacterized human 7BS MTase currently annotated as part of the endothelin converting enzyme 2, but which should be considered a separate enzyme...
August 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28443098/the-lysine-methyltransferase-g9a-in-immune-cell-differentiation-and-function
#15
REVIEW
Sebastian Scheer, Colby Zaph
G9a (KMT1C, EHMT2) is a lysine methyltransferase (KMT) whose primary function is to di-methylate lysine 9 of histone H3 (H3K9me2). G9a-dependent H3K9me2 is associated with gene silencing and acts primarily through the recruitment of H3K9me2-binding proteins that prevent transcriptional activation. Gene repression via G9a-dependent H3K9me2 is critically required in embryonic stem (ES) cells for the development of cellular lineages by repressing expression of pluripotency factors. In the immune system, lymphoid cells such as T cells and innate lymphoid cells (ILCs) can differentiate from a naïve state into one of several effector lineages that require both activating and repressive mechanisms to maintain the correct gene expression program...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28389916/a-direct-label-free-maldi-tof-mass-spectrometry-based-assay-for-the-characterization-of-inhibitors-of-protein-lysine-methyltransferases
#16
Karine Guitot, Thierry Drujon, Fabienne Burlina, Sandrine Sagan, Sandra Beaupierre, Olivier Pamlard, Robert H Dodd, Catherine Guillou, Gérard Bolbach, Emmanuelle Sachon, Dominique Guianvarc'h
Histone lysine methylation is associated with essential biological functions like transcription activation or repression, depending on the position and the degree of methylation. This post-translational modification is introduced by protein lysine methyltransferases (KMTs) which catalyze the transfer of one to three methyl groups from the methyl donor S-adenosyl-L-methionine (AdoMet) to the amino group on the side chain of lysines. The regulation of protein lysine methylation plays a primary role not only in the basic functioning of normal cells but also in various pathologies and KMT deregulation is associated with diseases including cancer...
June 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28357416/a-system-for-enzymatic-lysine-methylation-in-a-desired-sequence-context
#17
Vinay Kumar Aileni, Erna Davydova, Anders Moen, Pål Ø Falnes
A number of lysine-specific methyltransferases (KMTs) are responsible for the post-translational modification of cellular proteins on lysine residues. Most KMTs typically recognize specific motifs in unstructured, short peptide sequences. However, we have recently discovered a novel KMT that appeared to have a more relaxed sequence specificity, namely, valosin-containing protein (VCP)-KMT, which trimethylates Lys-315 in the molecular chaperone VCP. On the basis of this, here, we explored the possibility of using the VCP-KMT/VCP system to obtain specific lysine methylation of desired sequences grafted onto a VCP-derived scaffold...
February 28, 2017: ACS Omega
https://www.readbyqxmd.com/read/28325264/role-of-ketogenic-metabolic-therapy-in-malignant-glioma-a-systematic-review
#18
REVIEW
Sebastian F Winter, Franziska Loebel, Jorg Dietrich
BACKGROUND: Coined as the "Warburg effect" and a recognized hallmark of cancer, energy metabolism is aberrantly geared towards aerobic glycolysis in most human cancers, including malignant glioma. Ketogenic metabolic therapy (KMT), i.e. nutritional intervention with ketogenic or low-glycemic diets, has been proposed as an anti-neoplastic strategy in glioma patients. MATERIALS AND METHODS: We here review the rationale and existing data investigating KMT in management of patients with malignant glioma and discuss the promise and potential challenges of this novel strategy...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28187429/smyd2-lysine-methyltransferase-regulates-leukemia-cell-growth-and-regeneration-after-genotoxic-stress
#19
Adi Zipin-Roitman, Nasma Aqaqe, Muhammad Yassin, Shahar Biechonski, Mariam Amar, Mark F van Delft, Olga I Gan, Sean P McDermott, Alla Buzina, Troy Ketela, Liran Shlush, Stephanie Xie, Veronique Voisin, Jason Moffat, Mark D Minden, John E Dick, Michael Milyavsky
The molecular determinants governing escape of Acute Myeloid Leukemia (AML) cells from DNA damaging therapy remain poorly defined and account for therapy failures. To isolate genes responsible for leukemia cells regeneration following multiple challenges with irradiation we performed a genome-wide shRNA screen. Some of the isolated hits are known players in the DNA damage response (e.g. p53, CHK2), whereas other, e.g. SMYD2 lysine methyltransferase (KMT), remains uncharacterized in the AML context. Here we report that SMYD2 knockdown confers relative resistance to human AML cells against multiple classes of DNA damaging agents...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27913958/the-effect-of-mass-transfer-parameterization-and-ice-retention-on-the-scavenging-and-redistribution-of-so2-by-a-deep-convective-cloud
#20
Vladan Vučković, Dragana Vujović
A chemistry module with the aqueous chemistry coupled with the complex 3D nonhydrostatic atmospheric model is used to investigate how the representation of gas-aqueous mass transfer and ice retention affect the SO2 redistribution in the presence of a convective cloud. Gas uptake to the liquid water is calculated using both Henry's law equilibrium (HE) and kinetic mass transport (KMT). The constant retention coefficients for SO2 (k ret = 0.46) and for H2O2 (k ret = 0.64) are used. It is shown that the amount of SO2 in the air at higher altitudes (10-12 km) is greater when partial retention (PR) is included...
February 2017: Environmental Science and Pollution Research International
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