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https://www.readbyqxmd.com/read/29792855/the-versatile-hippo-pathway-in-oral-maxillofacial-development-and-bone-remodeling
#1
REVIEW
Lin Xiang, Hui Yu, Xinyuan Zhang, Bin Wang, Ying Yuan, Qin Zhang, Rui Ye, Ping Gong, Yingying Wu
The Hipposignaling pathway is implicated in key aspects of cell proliferation, control of organ size, stem cell functions and tumor suppression. Its functions are primarily mediated either through direct effects on transcription factors to influence target gene expression or through crosstalk with other signaling pathways that regulate multiple physiological activities. Studies are revealing Hippo pathway involvement in diverse functions including renewal of intestinal epithelium, promotion of myocardial cell proliferation, cancer suppression, etc...
May 21, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29792732/phosphatidylinositol-3-kinase-%C3%AE-and-%C3%AE-isoforms-play-key-roles-in-metastasis-of-prostate-cancer-du145-cells
#2
Zhe Zhang, Jie Liu, Yingying Wang, Xiao Tan, Wennan Zhao, Xiaoxue Xing, Yuling Qiu, Ran Wang, Meihua Jin, Guanwei Fan, Ping Zhang, Yuxu Zhong, Dexin Kong
Metastasis is the main cause of the lethality of prostate cancer. Class I phosphatidylinositol 3-kinases (PI3Ks), which contain 4 isoforms, α, β, δ, and γ, are known to play important roles in cell growth, migration, invasion, and so on. However, the respective role of each PI3K isoform in cancer cell migration and invasion remains unknown. In a study that aimed to elucidate the respective role of the 4 PI3K isoforms, we investigated the change in migratory and invasive ability of DU145 cells after treatment with each PI3K isoform-specific inhibitor...
May 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29792199/nanoparticle-delivery-of-grape-seed-derived-proanthocyanidins-to-airway-epithelial-cells-dampens-oxidative-stress-and-inflammation
#3
S Castellani, A Trapani, A Spagnoletta, L di Toma, T Magrone, S Di Gioia, D Mandracchia, G Trapani, E Jirillo, M Conese
BACKGROUND: Chronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endowed with well-recognized anti-oxidant, anti-inflammatory, anti-cancer, and anti-aging activities. Considering that natural anti-oxidants, such as proanthocyanidins, have poor water solubility and oral bioavailability, we have developed a drug delivery system based on solid lipid nanoparticles (SLN), apt to encapsulate grape seed extract (GSE), containing proanthocyanidins...
May 23, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29792123/user-acceptance-of-an-app-based-adherence-intervention-perspectives-from-patients-taking-oral-anticancer-medications
#4
Eskinder Eshetu Ali, Sharlene Si Ling Chan, Jo Lene Leow, Lita Chew, Kevin Yi-Lwern Yap
Background Widespread adoption by patients is imperative for the success of app-based interventions for enhancing adherence to oral anticancer medications. Patients' attitudes and beliefs should be evaluated to understand determinants of their acceptance and adoption of such interventions. Objective To identify factors that influence cancer patients' intention to adopt an app-based system for enhancing oral anticancer medication adherence. Methods This study was conducted as part of the usability evaluation of an app-based system for enhancing adherence...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29791975/cd44-and-aldh1-immunoexpression-as-prognostic-indicators-of-invasion-and-metastasis-in-oral-squamous-cell-carcinoma
#5
Rafael Carneiro Ortiz, Nathália Martins Lopes, Nadia Ghinelli Amôr, José Burgos Ponce, Cláudia Kliemann Schmerling, Vanessa Soares Lara, Raquel Ajub Moyses, Camila Oliveira Rodini
BACKGROUND: Tumour metastasis has been associated with cancer stem cells, a small population with stem-like cells properties, higher rate of migration and metastatic potential compared to cells from the tumour bulk. Our aim was to evaluate the immunoexpression of the putative cancer stem cell biomarkers ALDH1 and CD44 in primary tumour and corresponding metastatic lymph nodes. METHODS: Tumour tissue specimens (n=50) and corresponding metastatic lymph nodes (n=25) were surgically obtained from 50 patients with oral squamous cell carcinoma and submitted to immunohistochemistry...
May 23, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29791257/the-use-of-direct-oral-anticoagulants-in-the-treatment-of-acute-venous-thromboembolism-in-cancer-patients
#6
Hikmat Abdel-Razeq, Antoine Finianos, Ali T Taher
Introduction - After the CLOT study, LMWHs (low-molecular weight heparins) have gradually replaced warfarin as the treatment of choice for VTE (venous thromboembolism) in cancer patients. Randomized controlled studies comparing DOACs (direct oral anticoagulants) to LMWHs in cancer patients are still limited. However, new emerging data are supporting the use of DOACs in cancer-associated thrombosis. Areas Covered - This review will discuss the recent studies that addressed the utilization of such agents in the treatment of VTE in cancer patients...
May 23, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29790998/association-of-smokeless-tobacco-use-and-oral-cancer-a-systematic-global-review-and-meta-analysis
#7
Smita Asthana, Satyanarayana Labani, Uma Kailash, Dhirendra N Sinha, Ravi Mehrotra
Introduction: Smokeless tobacco products have been linked to precancerous and cancers of oral cavity for long. Evidence was available on the association between smokeless tobacco (SLT) products and oral cancers at regional but not at global level. Present meta-analysis is aimed to evaluate the risk of oral cancer with the use of SLT products among "ever" versus "never" users. Method: Studies published for the period (1960-2016) are retrieved using Pubmed, Indmed, EMBASE, and Google Scholar search engines for the subject "ever" versus "never" users of SLT products and estimated the risk association with oral cancer...
May 22, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29790745/vanillin-ameliorated-the-development-of-azoxymethane-dextran-sodium-sulfate-induced-murine-colorectal-cancer-the-involvement-of-proteasome-nuclear-factor-%C3%AE%C2%BAb-mitogen-activated-protein-kinase-pathways
#8
Jung-Miao Li, Yu-Chen Lee, Chia-Cheng Li, Hsin-Yi Lo, Feng-Yuan Chen, Yi-Siou Chen, Chien-Yun Hsiang, Tin-Yun Ho
Vanillin is a natural dietary flavoring widely used in food industry. Colorectal cancer (CRC) is one of the common malignancies in the world. Chronic intestinal inflammation is a risk factor for the development of CRC. We have previously found that vanillin improves and prevents colitis in mice. Here we evaluated the inhibitory activities of vanillin on a mouse model of colitis-induced CRC. Mice were challenged intraperitoneally with azoxymethane (AOM) and orally with dextran sodium sulfate (DSS). Various dosages of vanillin were orally administered for 13 consecutive weeks...
May 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29790687/expression-profiles-of-selected-genes-in-tumors-and-matched-surgical-margins-in-oral-cavity-cancer-do-we-have-to-pay-attention-to-the-molecular-analysis-of-the-surgical-margins
#9
Joanna K Strzelczyk, Łukasz Krakowczyk, Karolina Gołąbek, Aleksander J Owczarek
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are associated with an interplay between genetics and the environment; they account for 3% of all diagnosed malignant tumors in men and 2% of those in women. OBJECTIVES: The aim of the study was to analyze the significance of TIMP3, SFRP1, SFRP2, CDH1, RASSF1, RORA, and DAPK1 gene expression in head and neck squamous cell carcinoma tumors, and in matching surgical margin samples. We also analyzed the association between clinical parameters and the expression of the selected genes...
April 24, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790310/anticancer-activity-of-chlorhexidine-and-cranberry-extract-an-in-vitro-study
#10
Mahesh R Khairnar, Umesh Wadgave, Harish Jadhav, Rahul Naik
Introduction: Oral cancer is considered to be a global pandemic. The study was conducted to assess the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines. Material and Methods: Anticancer activity of CHX and Cranberry extract (CE) was assessed against AW13516 (poorly to moderately differentiated squamous cell carcinoma of tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assay at the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) Mumbai, India...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29790309/assessment-of-hospital-based-prevalence-of-oral-cancer-among-population-of-kanpur-uttar-pradesh
#11
Amrita Raj, Gayathri Ramesh, Sunita Pathak
Background: Oral cancer incidence depends on both qualitative and quantitative factors wherein the incidence of oral cancer in patients with smoking and tobacco chewing habit is 8.4 times higher than that of patients with no habit. Aim: To understand about the prevalence of oral cancer in population of Kanpur reported to the hospital and analyse the association with age, gender and tobacco habit. Material and Method: All 320 cases of Squamous cell carcinoma diagnosed histopathologically, since January 2007 to December 2016, were retrieved from the archives and a retrospective study was conducted along with association with the variables such as age, gender, site, habit and histopathological type...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29790306/the-role-of-novel-prognostic-markers-prox1-and-foxc2-in-carcinogenesis-of-oral-squamous-cell-carcinoma
#12
Neha S Agnihotri, Madhusudan Astekar
Oral squamous cell carcinoma is the most common malignant tumor of the head and neck regions and accounts for more than 90% of cancers in the oral cavity. The angiogenesis, lymphangiogenesis and epithelial mesenchymal transition are known to be pivotal for tumor progression and metastasis. In the last decade, much data has been generated concerning the molecular mechanisms of angiogenesis, lymphangiogenesis and its significance in pathological conditions. The main angiogenic and lymphangiogenic factors have been identified as vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR-2), forkhead box (FOX) C2 while vascular endothelial growth factor C/D (VEGF-C/D), vascular endothelial growth factor receptor 3 (VEGFR-3), Prospero homeobox 1 (PROX1), LYVE-1, podoplanin, Tie/Angioprotein (Ang) 2 and EphrinB2 respectively...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29789716/xct-slc7a11-mediated-metabolic-reprogramming-promotes-non-small-cell-lung-cancer-progression
#13
Xiangming Ji, Jun Qian, S M Jamshedur Rahman, Peter J Siska, Yong Zou, Bradford K Harris, Megan D Hoeksema, Irina A Trenary, Chen Heidi, Rosana Eisenberg, Jeffrey C Rathmell, Jamey D Young, Pierre P Massion
Many tumors increase uptake and dependence on glucose, cystine or glutamine. These basic observations on cancer cell metabolism have opened multiple new diagnostic and therapeutic avenues in cancer research. Recent studies demonstrated that smoking could induce the expression of xCT (SLC7A11) in oral cancer cells, suggesting that overexpression of xCT may support lung tumor progression. We hypothesized that overexpression of xCT occurs in lung cancer cells to satisfy the metabolic requirements for growth and survival...
May 23, 2018: Oncogene
https://www.readbyqxmd.com/read/29788694/long-term-rivaroxaban-for-the-treatment-of-acute-venous-thromboembolism-in-patients-with-active-cancer-in-a-prospective-multicenter-trial
#14
Ho-Young Yhim, Won-Il Choi, Sung-Hyun Kim, Seung-Hyun Nam, Kyoung Ha Kim, Yeung-Chul Mun, Doyeun Oh, Hun-Gyu Hwang, Keun-Wook Lee, Eun-Kee Song, Yong Shik Kwon, Soo-Mee Bang
Background/Aims: Limited data are available regarding the efficacy of rivaroxaban for the treatment of cancer-associated venous thromboembolism (VTE). The aim of this study was to evaluate the effectiveness and safety of rivaroxaban for the treatment of VTE in active cancer patients. Methods: In this prospective, multicenter, open-label trial (NCT01989845), we enrolled patients with active cancer and objectively diagnosed lower-extremity deep vein thrombosis, pulmonary embolism (PE), or both from November 2013 to June 2016...
May 23, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29788174/aspirin-abrogates-impairment-of-mammary-gland-differentiation-induced-by-early-in-life-second-hand-smoke-in-mice
#15
Julia Santucci-Pereira, Thomas J Pogash, Aman Patel, Navroop Hundal, Maria Barton, Anna Camoirano, Rosanna T Micale, Sebastiano La Maestra, Roumen Balansky, Silvio De Flora, Jose Russo
Epidemiological studies show that there is limited evidence that tobacco smoking causes breast cancer in humans. In rodents, many tobacco smoke chemicals cause mammary gland tumors. This study evaluated the mammary gland differentiation in mice exposed to environmental cigarette smoke (ECS), using 3R4F Kentucky reference cigarettes, starting after birth and continuing daily for 10 weeks (total particulate exposure 95 mg/m3; CO 610 ppm). We also analyzed the effects of oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin (1600mg/kg) or naproxen (320mg/kg), on mammary gland differentiation, either in unexposed or ECS-exposed mice...
May 17, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29788170/systematic-review-and-meta-analysis-of-the-evidence-for-oral-nutritional-intervention-on-nutritional-and-clinical-outcomes-during-chemo-radio-therapy-current-evidence-and-guidance-for-design-of-future-trials
#16
M A E de van der Schueren, A Laviano, H Blanchard, M Jourdan, J Arends, V E Baracos
Background: Driven by reduced nutritional intakes and metabolic alterations, malnutrition in cancer patients adversely affects quality of life, treatment tolerance and survival. We examined evidence for oral nutritional interventions during chemo(radio)therapy. Design: We carried out a systematic review of randomized controlled trials (RCT) with either dietary counseling (DC), high-energy oral nutritional supplements (ONS) aiming at improving intakes or ONS enriched with protein and n-3 polyunsaturated fatty acids (PUFA) additionally aiming for modulation of cancer-related metabolic alterations...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29787991/synthetic-chalcones-as-potential-tool-for-acute-and-chronic-pain-control
#17
Lilian W Rocha, Daniele R Sonza, Milena Fronza Broering, Roberta Nunes, Fátima de Campos-Buzzi, Rogério Corrêa, Rangel L Silva, Thiago M Cunha, José Roberto Santin, Nara L M Quintão
The purpose of this study was to validate the potential anti-hypersensitive activity of two chalcones, (2E)-1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one (ANCh) and N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoil]phenyl}acetamide (AcANCh), by different models of acute and persistent pain in mice, besides in silico analysis. Molecules computational investigation for prediction of Lipinki's and Veber's rules to determine solubility, % absorption, drug likeness and toxicity liabilities was performed. Male and female C57BL/6 mice (20-30 g, n = 6) were used...
May 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29787349/head-and-neck-cancer-patients-rates-reasons-and-risk-factors-for-30-day-unplanned-readmission
#18
Michael K Ghiam, Alexander Langerman, Zoukaa Sargi, Sarah Rohde
Objective To analyze rates, risk factors, and complications for 30-day readmission among head and neck cancer (HNC) patients. Methods Retrospective review of administrative records from Vizient (Irving, Texas) Clinical Data Base/Resource Manager on HNC patients who underwent a head and neck surgical procedure from January 2013 through September 2015 at 176 academic and community medical centers. Results Of the 18,121 patients included in the study, 2502 patients were readmitted within 30 days (13.8%). Mean time to readmission was 11 ± 8...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29787332/comparison-of-nine-tools-for-screening-drug-drug-interactions-of-oral-oncolytics
#19
Lauren A Marcath, Jingyue Xi, Emily K Hoylman, Kelley M Kidwell, Shawna L Kraft, Daniel L Hertz
PURPOSE: Patients with cancer are an especially vulnerable population to potential drug-drug interactions (DDIs). This makes it important to adequately screen them for DDIs. The objective of this study was to compare the abilities of nine DDI screening tools to detect clinically relevant interactions with oral oncolytics. METHODS: Subscription-based tools (ie, PEPID, Micromedex, Lexicomp, Facts & Comparisons) and free tools (ie, Epocrates Free, Medscape, Drugs...
May 22, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29787262/discovery-of-novel-pazopanib-based-hdac-and-vegfr-dual-inhibitors-targeting-cancer-epigenetics-and-angiogenesis-simultaneously
#20
Jie Zang, Xuewu Liang, Yongxue Huang, Yuping Jia, Xiaoyang Li, Wenfang Xu, C James Chou, Yingjie Zhang
Herein a novel series of pazopanib hybrids as polypharmacological antitumor agents were developed based on the crosstalk between histone deacetylases (HDACs) and vascular endothelial growth factor (VEGF) pathway. Among them, one ortho-aminoanilide 6d and one hydroxamic acid 13f exhibited considerable total HDACs and VEGFR-2 inhibitory activities. The HDAC inhibitory activities endowed 6d and 13f with potent antiproliferative activities, which was not observed in the approved VEGFR inhibitor pazopanib. Compounds 6d and 13f possessed comparable HDAC isoform selectivity profiles to the clinical class I HDAC inhibitor MS-275 and the approved pan-HDAC inhibitor SAHA, respectively...
May 22, 2018: Journal of Medicinal Chemistry
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