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Hypothyroidism

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https://www.readbyqxmd.com/read/29029094/thyroid-hormone-metabolism-defects-in-a-mouse-model-of-sbp2-deficiency
#1
Jiao Fu, Haruki Fujisawa, Benjamin Follman, Xiao-Hui Liao, Alexandra M Dumitrescu
SBP2 (selenocysteine insertion sequence binding protein 2) is an essential factor in selenoprotein synthesis. Patients with SBP2 defects have a characteristic thyroid phenotype and additional manifestations such as growth delay, male infertility, impaired motor coordination and developmental delay. The thyroid phenotype has become pathognomonic for this defect and putative deficiencies in the iodothyronine deiodinases selenoenzymes have been implicated. To investigate the role of SBP2 and selenoproteins in thyroid physiology and answer questions raised by the human syndrome we generated a tamoxifen inducible Sbp2 conditional knockout (iCKO) mouse model...
September 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29026751/association-of-thyroid-peroxidase-antibody-and-dyslipidemia-in-subclinical-hypothyroidism
#2
Vikas Kumar Srivastava, Harkaran Singh
CONTEXT: Subclinical hypothyroidism (SCH) is stated as mild thyroid failure, is more common as compared to overt hypothyroidism, is associated with different biochemical abnormalities such as dyslipidemia, and is also having high conversion rate into overt hypothyroidism in patients having thyroid peroxidase (TPO) antibody positive. Lipid abnormalities are controversial in SCH and there is lack of Indian studies showing correlation between lipid abnormalities and TPO positivity in SCH...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#3
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29026409/hemostasis-in-hypothyroidism-and-autoimmune-thyroid-disorders
#4
REVIEW
Arash Ordookhani, Kenneth D Burman
CONTEXT: There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders. EVIDENCE ACQUISITION: A comprehensive literature search was conducted employing MEDLINE database...
April 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29026407/congenital-hypothyroidism-insights-into-pathogenesis-and-treatment
#5
REVIEW
Christine E Cherella, Ari J Wassner
Congenital hypothyroidism occurs in approximately 1 in 2000 newborns and can have devastating neurodevelopmental consequences if not detected and treated promptly. While newborn screening has virtually eradicated intellectual disability due to severe congenital hypothyroidism in the developed world, more stringent screening strategies have resulted in increased detection of mild congenital hypothyroidism. Recent studies provide conflicting evidence about the potential neurodevelopmental risks posed by mild congenital hypothyroidism, highlighting the need for additional research to further define what risks these patients face and whether they are likely to benefit from treatment...
2017: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/29026381/a-cross-sectional-analysis-of-the-association-between-age-and-gender-and-prescribed-minimum-benefit-chronic-disease-list-conditions-among-south-africans-with-concomitant-hypertension-diabetes-and-dyslipidaemia
#6
Johanita Burger, Martie Lubbe, Jan Serfontein, Suria Ellis
BACKGROUND: Prescribed Minimum Benefit Chronic Disease List (PMB CDL) conditions are a regulated list of conditions most common to South Africa. OBJECTIVES: To investigate the prevalence and association between PMB CDL conditions and age and gender among patients with concomitant hypertension, diabetes and dyslipidaemia. METHODS: The study population consisted of patients (n = 17 866) with a prescription containing at least one co-prescribed antilipemics, antihypertensive and antidiabetic (identified using the MIMS Desk Reference)...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29026269/clinical-characteristics-of-septo-optic-dysplasia-accompanied-by-congenital-central-hypothyroidism-in-japan
#7
Keisuke Nagasaki, Takuo Kubota, Hironori Kobayashi, Hirotake Sawada, Chikahiko Numakura, Shohei Harada, Kei Takasawa, Kanshi Minamitani, Tomohiro Ishii, Satoshi Okada, Hotaka Kamasaki, Shigetaka Sugihara, Masanori Adachi, Toshihiro Tajima
Septo-optic dysplasia (SOD) is a congenital anomaly in which agenesis of the septum pellucidum and optic nerve hypoplasia are accompanied by hypopituitarism. Typically, the symptoms develop in 3 organs, the brain, eyes, and pituitary, and approximately one third of the patients present with all of the three cardinal features. The diagnostic criteria for SOD were established in Japan in 2015. The purpose of this study is to review clinical features regarding SOD patients with hypopituitarism in Japan. In this study, 21 patients with SOD were identified by a questionnaire survey for congenital central hypothyroidism...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29024619/korean-pediatric-reference-intervals-for-ft4-tsh-and-tpo-ab-and-the-prevalence-of-thyroid-dysfunction-a-population-based-study
#8
Han Hyuk Lim
BACKGROUND: The appropriate age-related reference intervals for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) are important in interpreting the results of thyroid function tests in children and adolescents. However, these reference intervals are scanty. This study aimed to establish the reference intervals for FT4, TSH, and thyroid peroxidase antibody (TPO Ab), and identify the epidemiological prevalence of thyroid dysfunction in a Korean pediatric population. METHODS: The data from a sample of 2042 children and adolescents aged 10-18years who underwent a nationwide Korean representative sampling and cross-sectional survey with blood collection for a thyroid function test using an electrochemiluminescence immunoassay were evaluated...
October 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29024024/altered-serum-thyrotropin-concentrations-in-dogs-with-primary-hypoadrenocorticism-before-and-during-treatment
#9
C E Reusch, F Fracassi, N S Sieber-Ruckstuhl, W A Burkhardt, N Hofer-Inteeworn, C Schuppisser, M Stirn, R Hofmann-Lehmann, F S Boretti
BACKGROUND: Thyrotropin (TSH) can be increased in humans with primary hypoadrenocorticism (HA) before glucocorticoid treatment. Increase in TSH is a typical finding of primary hypothyroidism and both diseases can occur concurrently (Schmidt's syndrome); therefore, care must be taken in assessing thyroid function in untreated human patients with HA. OBJECTIVE: Evaluate whether alterations in cTSH can be observed in dogs with HA in absence of primary hypothyroidism...
October 11, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29023978/weight-gain-after-treatment-of-graves-disease-in-children
#10
G Todd Alonso, Shona Rabon, Perrin C White
OBJECTIVE: The frequency of and risk factors for weight gain in children treated for Graves disease have not been described. We evaluated change in BMI Z score and predictors of weight gain in this population. DESIGN: Retrospective review of data from January 2000 to July 2011. PATIENTS: 222 children and adolescents with Graves' disease (ages 2-18 years) evaluated following radioactive iodine administration (RAI) (n=101), thyroidectomy (n=9), and initiation of medical therapy (n=112)...
October 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29021704/the-effect-of-red-ginseng-and-ginseng-leaves-on-the-substance-and-energy-metabolism-in-hypothyroidism-rats
#11
Hang Xiao, Cheng Tan, Guanlin Yang, Deqiang Dou
BACKGROUND: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism. MATERIALS AND METHODS: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29016752/hypothyroidism-and-congenital-long-qt-additive-effect-causing-torsades
#12
Moustafa Elsheshtawy, Felix Yang, Ashok Khanna
No abstract text is available yet for this article.
July 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016579/iodine-and-thyroid-function-status-and-anti-thyroid-peroxidase-antibody-among-pregnant-women-in-eastern-nepal
#13
Lalit Narayan Chaudhary, Saroj Khatiwada, Basanta Gelal, Sharad Gautam, Madhab Lamsal, Hanoon Pokharel, Nirmal Baral
BACKGROUND: Iodine deficiency, thyroid dysfunction and development of thyroid autoimmunity during pregnancy may affect mother and the developing fetus. This study was carried out to find iodine status, thyroid dysfunction and thyroid autoimmunity among pregnant women. METHODS: Ninety two pregnant women from three districts of eastern Nepal (Sunsari, Morang and Jhapa) were enrolled for the study, and urine and blood samples were collected. Urinary iodine concentration (UIC), free thyroxine (free T4), thyroid stimulating hormone (TSH), thyroglobulin and anti-thyroid peroxidase (TPO) antibody levels were estimated...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28993437/thyroid-hormone-regulates-protease-expression-and-activation-of-notch-signaling-in-implantation
#14
Diletta Piccirilli, Enke Baldini, Micol Massimiani, Antonella Camaioni, Antonietta Salustri, Roberta Bernardini, Marco Centanni, Salvatore Ulisse, Constanzo Moretti, Luisa Campagnolo
A clinical association between thyroid dysfunction and pregnancy complications has been extensively reported, however the molecular mechanisms through which TH might regulate key-events of pregnancy have not been elucidated yet. In this respect, we performed in vivo studies in MMI- induced hypothyroid pregnant mice, evaluating the effect of hypothyroidism on the number of implantation sites, developing embryos/resorptions and pups per litter, at 4.5, 10.5, 18.5 days post coitum (dpc) and at birth. We also studied the expression of major molecules involved in implantation and placentation, such as the proteases ISPs, MMPs, TIMPs and Notch pathway related genes...
October 9, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28993425/wrist-mass-in-a-93-year-old-woman
#15
Annette Marie Maznyczka, Domenico Valenti, Jonathan Byrne
A 93-year-old woman presented electively for transaortic valve implantation (TAVI), for severe aortic stenosis. She had a history of hypertension and hypothyroidism, and she was taking clopidogrel, antihypertensives and levothyroxine. In preparation for her TAVI procedure she underwent coronary angiography 4 months previously. Her coronary angiogram revealed severe three vessel disease, however, the consensus from the multidisciplinary team meeting, at that time, was to manage the coronary disease medically...
October 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28989881/iodine-status-among-subclinical-and-overt-hypothyroid-patients-by-urinary-iodine-assay-a-case-control-study
#16
Uma Shrestha, Narayan Gautam, Krishna Kumar Agrawal, Amit Chandra Jha, Archana Jayan
OBJECTIVES: The objective of the study was to assess the differences of iodine status as measured by urinary iodine excretion (UIE) between cases of hypothyroidism and healthy controls. MATERIALS AND METHODS: The study was conducted in cases with subclinical hypothyroidism (n = 58) and overt hypothyroidism (n = 41) and compared with age- and sex-matched healthy euthyroid controls (n = 52) attending Universal College of Medical Sciences Teaching Hospital, Bhairahawa, Nepal...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989877/postpartum-follow-up-in-women-diagnosed-with-subclinical-hypothyroidism-during-pregnancy
#17
K Neelaveni, K V S Hari Kumar, Rakesh Sahay, Jayanthy Ramesh
BACKGROUND: Management guidelines about the thyroid disease in pregnancy are silent about the postpartum course of new onset subclinical hypothyroidism (SCH). Hence, we analyzed the 2 years outcome of SCH diagnosed during pregnancy. MATERIALS AND METHODS: We conducted this retrospective study using the medical records of patients with new onset SCH during pregnancy between 2010 and 2013 (n = 718). Patients who stopped their levothyroxine after delivery with a 2-year follow-up record were included...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989870/prepregnancy-hypothyroidism-versus-gestational-hypothyroidism-a-comparative-study
#18
Prashant Ulhas Kaduskar, Mala Dharmalingam, Pramila Kalra
INTRODUCTION: Hypothyroidism managed inadequately in pregnancy may have grave outcomes for both mother and baby. Understanding pregnancy outcomes in our country with low awareness about thyroid diseases is important. OBJECTIVES: The objectives of the study were to evaluate demographic features and biochemical parameters in patients with prepregnancy hypothyroidism versus patients diagnosed to have primary hypothyroidism during pregnancy and to assess pregnancy outcomes...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28988411/how-reliably-can-computed-tomography-predict-thyroid-invasion-prior-to-laryngectomy
#19
Andrew S Harris, Carl D Passant, Duncan R Ingrams
OBJECTIVES/HYPOTHESIS: There is little evidence to support the removal of thyroid tissue during total laryngectomy. Although oncological control of the tumor is the priority, thyroidectomy can lead to hypothyroidism and hypoparathyroidism. This study aimed to test the usefulness of preoperative computed tomography in predicting histological invasion of the thyroid. STUDY DESIGN: Ambispective cohort study. METHODS: All patients undergoing total laryngectomy for squamous cell carcinoma at one center from 2006 to 2016 were included...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28987238/thyroid-stimulating-hormone-exhibits-the-impact-on-ldlr-ldl-c-via-up-regulating-hepatic-pcsk9-expression
#20
Yingyun Gong, Yizhe Ma, Zhengqin Ye, Zhenzhen Fu, Panpan Yang, Beibei Gao, Wen Guo, Dandan Hu, Jingya Ye, Shuai Ma, Fan Zhang, Li Zhou, Xinyu Xu, Zhong Li, Tao Yang, Hongwen Zhou
CONTEXT: Thyroid stimulating hormone (TSH) has received increasing attention as being closely associated with increased low-density lipoprotein cholesterol (LDL-c) level and higher atherosclerotic risks. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is known for increasing circulating LDL-c level by inducing LDL receptor degradation. However, whether TSH influences hepatic PCSK9 expression and LDL-c metabolism remains unclear. METHODS: First, the correlation between TSH and lipid profiles were investigated in euthyroid population and in subclinical hypothyroidism patients...
November 2017: Metabolism: Clinical and Experimental
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