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https://www.readbyqxmd.com/read/29222266/impact-of-bone-disease-and-pain-in-thalassemia
#1
REVIEW
Antonio Piga
Conventional treatment of thalassemia, namely regular blood transfusion and iron chelation, improves perspectives and quality of life; however, successful treatment leads to more time in which long-term complications such as bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects, from bone anatomy and bone quality to mineral density, may be affected, with important morbidity including osteoporosis, fractures, spinal deformities, nerve compression, and pain. Clinical presentations include growth impairment, rickets-like features, back pain, spinal deformities, any sign of nerve compression, severe osteoporosis, and fragility fractures...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221723/effects-of-thyroxine-on-expression-of-proteins-related-to-thyroid-hormone-functions-tr-%C3%AE-tr-%C3%AE-rxr-and-erk1-2-in-uterus-during-peri-implantation-period
#2
Abu Sadat Md Sayem, Nelli Giribabu, Sekaran Muniandy, Naguib Salleh
INTRODUCTION: Thyroid hormone is known to play important role during embryo implantation, however mechanisms underlying its actions in uterus during peri-implantation period has not been fully identified. In this study, we hypothesized that thyroid hormone could affect expression of proteins related to its function, where these could explain mechanisms for its action in uterus during this period. METHODS: Female rats, once rendered hypothyroid via oral administration of methimazole (0...
December 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29220528/maternal-thyroid-function-in-early-pregnancy-and-neuropsychological-performance-of-the-child-at-5-years-of-age
#3
Stine Linding Andersen, Stig Andersen, Zeyan Liew, Peter Vestergaard, Jørn Olsen
Context: Abnormal maternal thyroid function in pregnancy may impair fetal brain development, but more evidence is needed to refine and corroborate the hypothesis. Objective: To estimate the association between maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age. Design: Follow-up study. Participants: A cohort of 1,153 women and their children sampled from the Danish National Birth Cohort...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29218227/lessons-learnt-from-a-case-of-missed-central-hypothyroidism
#4
Tessa Glyn, Beverley Harris, Kate Allen
We present the case of a 57-year-old lady who had a delayed diagnosis of central hypothyroidism on a background of Grave's thyrotoxicosis and a partial thyroidectomy. During the twenty years following her partial thyroidectomy, the patient developed a constellation of symptoms and new diagnoses, which were investigated by numerous specialists from various fields, namely rheumatology, renal and respiratory. She developed significantly impaired renal function and raised creatine kinase (CK). She was also referred to a tertiary neurology service for investigation of myositis, which resulted in inconclusive muscle biopsies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29214681/thyroid-hormones-alter-estrous-cyclicity-and-antioxidative-status-in-the-ovaries-of-rats
#5
Quanwei Wei, Jaafar Sulieman Fedail, Lingfa Kong, Kaizhi Zheng, Chunhua Meng, Mohamed Babo Fadlalla, Fangxiong Shi
To expand our understanding of the roles of thyroid hormones on female reproduction, we induced hypo- and hyper-T rat models to investigate the roles of thyroid hormones on estrous cyclicity, as well as the antioxidative status in the ovaries of rats. In the current study, our data show that hypothyroidism (hypo-T) and hyperthyroidism (hyper-T) led to significantly reduced body weights and ovarain weights and delayed vaginal opening day. For hyper-T, thyroxine (T4), tri-iodothyronine (T3), progesterone (P4) and follicle-stimulating hormone (FSH) were significantly increased, while estradiol (E2) and luteinizing hormone (LH) were significantly decreased...
December 7, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29214182/thyroid-dysfunction-among-greek-patients-with-type-1-and-type-2-diabetes-mellitus-as-a-disregarded-comorbidity
#6
Maria E Barmpari, Maria Kokkorou, Anastasia Micheli, Irene Alexiou, Elefteria Spanou, Marina Noutsou, Anastasia Thanopoulou
Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes mellitus as well as its possible relations to glycaemic control and to diabetic complications. Methods: A total of 1015 patients, consecutively followed in the Outpatient Diabetes Center, were studied. Anthropometric and biochemical measurements, occurrence of diabetes complications, and classical comorbidities were assessed...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29213166/precocious-puberty-an-experience-from-a-major-teaching-hospital-in-central-saudi-arabia
#7
Huda A Osman, Nasir A M Al-Jurayyan, Amir M I Babiker, Hessah M N Al-Otaibi, Reem D H AlKhalifah, Sharifah D A Al Issa, Sarar Mohamed
Precocious puberty is a developmental process that gives rise to secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. In general, precocious puberty can be classified as central or peripheral. This is a retrospective hospital-based study was conducted at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia, during the period January 1990 and December 2016. Data were abstracted from the medical records of patients diagnosed with precocious puberty, with special emphasis on age, sex, clinical characteristics, and relevant hormonal assay...
2017: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/29212453/mortality-in-persons-with-undetected-and-diagnosed-hypertension-type-2-diabetes-and-hypothyroidism-compared-with-persons-without-corresponding-disease-a-prospective-cohort-study-the-hunt-study-norway
#8
Pål Jørgensen, Arnulf Langhammer, Steinar Krokstad, Siri Forsmo
BACKGROUND: Suggested strategies in reducing the impact of non-communicable diseases (NCD) are early diagnosing and screening. We have limited proof of benefit of population screening for NCD. Increased mortality in persons with diagnosed NCD has been shown for decades. However, mortality in undetected NCD has barely been studied. This paper explores whether all-cause mortality differed between persons with diagnosed hypothyroidism, type 2 diabetes (T2DM), and hypertension, compared with persons with undetected-, and with persons without the corresponding disease...
December 7, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/29212434/stable-isotope-pharmacokinetic-studies-provide-insight-into-effects-of-age-sex-and-weight-on-levothyroxine-metabolism
#9
Islam Younis, Mariam A Ahmed, Kenneth D Burman, Offie P Soldin, Jacqueline Jonklaas
Background We wished to determine whether levothyroxine pharmacokinetics (PKs) are affected by age, weight, and sex. Methods A pharmacokinetic study was performed after administration of a tracer dose of carbon-13- labeled LT4 (13C-LT4). The study was conducted at an academic medical center. Adults of any age being treated with levothyroxine for hypothyroidism were enrolled in the study. A single dose of 13C- LT4 was administered. Eighteen serial plasma samples were collected. One sample was obtained before the 13C- LT4 dose and the majority of the remaining samples were collected over the 120-hour period post-dosing...
December 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29210006/triiodothyronine-differentially-modulates-the-lh-and-fsh-synthesis-and-secretion-in-male-rats
#10
Renata Marino Romano, Paula Bargi-Souza, Erika Lia Brunetto, Francemilson Goulart-Silva, Renato M Salgado, Telma Maria Tenorio Zorn, Maria Tereza Nunes
Hypothyroidism and thyrotoxicosis produce adverse effects in male reproduction by unknown mechanisms. We investigated whether triiodothyronine (T3) modulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) synthesis/secretion, by inducing different thyroid states. In hypothyroidism, the content of Lhb and Fshb mRNAs was increased, while their association to ribosomes and the protein content were reduced and the serum LH and FSH concentrations were augmented and decreased, respectively. Thyrotoxicosis reduced Lhb mRNA and LH serum concentration, and increased Lhb mRNA translational rate...
December 5, 2017: Endocrine
https://www.readbyqxmd.com/read/29209896/braf-oncogene-induced-senescence-and-the-role-of-thyroid-stimulating-hormone-signaling-in-the-progression-of-papillary-thyroid-carcinoma
#11
REVIEW
F I Moulana, A A H Priyani, M V C de Silva, R S Dassanayake
Oncogene-induced senescence (OIS) explains the phenomenon of cellular senescence triggered by the action of oncogenes. It is a mechanism adopted by a cell to inhibit progression of benign tumors into malignancy, occurs in premalignant lesions, and is almost never present in malignant lesions. BRAF mutations occur in about 40-45% of all papillary thyroid carcinomas (PTCs) and of which 99.7% is the BRAFV600E mutation. A unique phenotype of the BRAFV600E mutation is the upregulation of the thyroid-stimulating hormone receptor (TSHR) on thyrocyte membranes...
December 5, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/29209734/effects-of-hypothyroidism-on-serotonin-1a-receptors-in-the-rat-brain
#12
Jae-Hoon Lee, Minkyung Lee, Ji-Ae Park, Young Hoon Ryu, Kyo Chul Lee, Kyeong Min Kim, Jae Yong Choi
PURPOSE: We investigated the effects of hypothyroidism on serotonin 1A receptors in the rat brain in vivo. METHODS: Five surgically thyroidectomized male Sprague-Dawley (SD) rats and five hypophysectomized SD rats were used as animal models of hypothyroidism; the same number of sham-operated SD rats served as age-matched controls. After hypothyroidism was confirmed by thyroid function tests, serotonin positron emission tomography (PET) was performed for 120 min...
December 5, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29209276/l-thyroxine-in-an-oral-liquid-or-softgel-formulation-ensures-more-normal-serum-levels-of-free-t4-in-patients-with-central-hypothyroidism
#13
Salvatore Benvenga, Giovanni Capodicasa, Sarah Perelli
Context: l-Thyroxine (l-T4) therapy of central hypothyroidism (CH) is guided by measurements of serum free thyroxine (FT4), which should be above the midnormal range value (MNRV). In some countries, novel formulations of oral l-T4 (liquid or softgel) are available further to the classic tablets. The intestinal absorption of either novel formulation is greater than tablets in patients with primary hypothyroidism. Objective: To evaluate whether new oral formulations of l-T4 could be considered optimal in patients with CH who do not reach the FT4 target using tablet l-T4...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29208878/study-of-thyroid-disorders-among-type-2-diabetic-patients-attending-a-tertiary-care-hospital
#14
N Z Khan, M A Muttalib, G S Sultana, F A Mishu, A Nesa
Type 2 diabetes mellitus (T2DM) and thyroid disorders (TD) are the two most common endocrine disorders in clinical practice. Unrecognized thyroid disorders may adversely affect the metabolic control and add more risk to an already predisposing type 2 diabetes mellitus. The objective of the study is to find out the percentage of hypothyroidism and hyperthyroidism in patients with type 2 diabetes mellitus and non diabetic subjects. This cross-sectional study was conducted in the department of Biochemistry and outpatient Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh from July 2014 to June 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29205102/crispr-cas9-editing-of-the-mouse-thra-gene-produces-models-with-variable-resistance-to-thyroid-hormone
#15
Suzy Markossian, Romain Guyot, Sabine Richard, Marie Teixeira, Nadine Aguilera, Mathilde Bouchet, Michelina Plateroti, Wenyue Guan, Karine Gauthier, Denise Aubert, Frederic Flamant
Resistance to thyroid hormone due to THRA mutations (RTHα) is a recently discovered genetic disease, displaying important variability in its clinical presentation. The mutations alter the function of TRα1, one of the two nuclear receptors for thyroid hormone. Our aim was to understand the relationship between specific THRA mutations and phenotype. We used CRISPR/Cas9 genome editing to generate 5 new mouse models of RTHα, with frameshift or missense mutations. Like human patients, mutant mice displayed a hypothyroid-like phenotype, with altered development...
December 5, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29204393/lymphocutaneous-sporotrichosis-treated-with-potassium-iodide-with-development-of-subclinical-hypothyroidism-wolff-chaikoff-effect
#16
Pooja Arora, M Raihan, Asha Kubba, Ram K Gautam
Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. In this article, we report a 60-year-old female with lymphocutaneous sporotrichosis that responded well to potassium iodide. However, subclinical hypothyroidism (Wolff-Chaikoff effect) was encountered as a side effect of therapy which was managed with thyroxine replacement...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204279/sellar-plasmacytoma-presenting-with-symptoms-of-anterior-pituitary-dysfunction
#17
Ana G Ferreira, Tiago N Silva, Henrique V Luiz, Filipa D Campos, Maria C Cordeiro, Jorge R Portugal
Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. We describe a case associated with extensive anterior pituitary involvement, which is a rare form of presentation. A 68-year-old man was referred to our Endocrinology outpatient clinic due to gynecomastia, reduced libido and sexual impotence...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29204277/cytomegalovirus-mononucleosis-induced-thyroiditis-in-an-immunocompetent-patient
#18
V Larouche, M Tamilia
Enteroviruses, including coxsackieviruses and Echovirus, are well known pathogens responsible for the development of thyroiditis. We describe the case of a 49-year-old woman with no personal or family history of thyroid disease who presented to the emergency room with a two-week history of daily fevers up to 39°C, a sore throat, occasional palpitations and diaphoresis, decreased appetite and an unintentional 10 kg weight loss over the same time course Physical examination revealed mild tachycardia, an intention tremor and a normal-sized, nontender thyroid gland without palpable nodules...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29201074/worldwide-recall-rate-in-newborn-screening-programs-for-congenital-hypothyroidism
#19
REVIEW
Ladan Mehran, Davood Khalili, Shahin Yarahmadi, Atieh Amouzegar, Mehdi Mojarrad, Nasrin Ajang, Fereidoun Azizi
Context: Neonatal mass screening program for congenital hypothyroidism provides the best tool for prevention of its devastating effects on mental development. Despite the overall success of the screening programs in detecting congenital hypothyroidism and eliminating its sequelae and new developments made in the program design, high recall rate and false positive results impose a great challenge worldwide. Lower recall rate and false positive results may properly organize project expenses by reducing the unnecessary repeated laboratory tests, increase physicians and parents' assurance and cooperation, as well as reduce the psychological effects in families...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29199370/measuring-medication-adherence-in-older-community-dwelling-patients-with-multimorbidity
#20
San Kim, Kathleen Bennett, Emma Wallace, Tom Fahey, Caitriona Cahir
PURPOSE: Older people with several chronic conditions require multiple drugs from different classes to be adequately treated. This study aims to: (i) measure medication adherence across multiple conditions and therapeutic drug groups in older community-dwelling patients, and (ii) examine the effect of multimorbidity on adherence. METHODS: This is a retrospective cohort study of medication adherence in 855 community-dwelling patients aged ≥ 70 years from 15 practices in Ireland using the Health Service Executive Primary Care Reimbursement Service (HSE-PCRS) pharmacy claims database...
December 3, 2017: European Journal of Clinical Pharmacology
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