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Epithelioid GIST differential diagnosis

https://read.qxmd.com/read/33355706/-uncommon-tumor-of-the-gastric-wall
#21
JOURNAL ARTICLE
T Hansen, U Titze, F Trachte, K Maschuw, W Hiller, J J Tebbe
We report on a 72-year-old male patient suffering from weight loss, diarrhea, and epigastric pain. By means of endosonographic ultrasound, a well-circumscribed tumor mass was found in the gastric wall, suggesting a gastrointestinal stromal tumor (GIST). Biopsies were taken and processed for standard histopathological analysis. The microscopy revealed uniform, small, round cells with central nuclei and prominent cell borders embedded in vascularized stroma. Immunohistochemistry demonstrated the expression of actin, but showed negativity for cytokeratin, CD34, CD117, DOG‑1, desmin, and CD45...
May 2021: Der Pathologe
https://read.qxmd.com/read/33280280/concomitant-neuroendocrine-tumor-and-gastrointestinal-stromal-tumor-in-a-duodenal-fine-needle-aspiration-a-cytologic-clue-for-neurofibromatosis-type-1
#22
JOURNAL ARTICLE
Tien Anh N Tran, Armando Rosales, J Pablo Arnoletti, Jie Ouyang, Muhammad K Hasan
The identification of two cell populations displaying different cytologic characteristics in the same fine needle aspiration (FNA), one with an epithelioid appearance and the other spindle cell morphology, is an extremely rare phenomenon and potentially represents a source of diagnostic confusion. Depending on the lineage and relationship of the two cell types, the differential diagnosis is broad and encompasses a wide spectrum of entities. The current case describes the presence of nests and clusters of neuroendocrine cells associated with rare spindle cell fragments of gastrointestinal stromal tumor (GIST) in the same fine needle aspiration of a duodenal mass...
February 2021: Diagnostic Cytopathology
https://read.qxmd.com/read/31043173/nuclear-tfe3-expression-is-a-diagnostic-marker-for-desmoid-type-fibromatosis
#23
JOURNAL ARTICLE
Luting Zhou, Haimin Xu, Jun Zhou, Lei Dong, Peipei Zhang, Xiaoqun Yang, Chaofu Wang
BACKGROUND: Desmoid-type fibromatosis (DTF) is a lesion characterized by clonal proliferation of myofibroblasts, which exhibits an infiltrative growth pattern. It is necessary for them to be distinguished from other fibroblastic and myofibroblastic lesions as well as spindle cell tumors. Altered Wnt signaling can act as a defining characteristic of DTF, with nuclear β-catenin serving as a diagnostic marker for. Transcription factor E3 (TFE3) has been linked to Wnt pathway activation and regulation, and may add value to the diagnosis of DTF...
May 1, 2019: Diagnostic Pathology
https://read.qxmd.com/read/29971258/differential-diagnosis-of-gastrointestinal-stromal-tumor-by-histopathology-and-immunohistochemistry
#24
REVIEW
Seiichi Hirota
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal (GI) tract. GISTs account for approximately 80% of the clinically relevant GI mesenchymal tumors. Although most GISTs show spindle cell morphology, 10-15% of GISTs show pure epithelioid configuration. Therefore, not only spindle cell tumors but also epithelioid cell ones developing in the GI tract are subject to the differential diagnoses of GISTs. GISTs are basically positive for KIT, a receptor tyrosine kinase (RTK) encoded by protooncogene c -kit , by immunohistochemistry, but approximately 5% of GISTs are only weakly or barely positive for KIT...
2018: Translational Gastroenterology and Hepatology
https://read.qxmd.com/read/28553740/extragastrointestinal-stromal-tumor-of-the-abdominal-subcutaneous-tissue-report-of-a-very-rare-case-at-an-unusual-site
#25
JOURNAL ARTICLE
Xue He, Nannan Chen, Li Lin, Congyang Wang, Yan Wang
Extragastrointestinal stromal tumors (EGISTs) are rare tumors that arise outside the digestive tract. We report a case of an EGIST arising in the subcutaneous tissue of the abdominal wall, which at this site can often be misdiagnosed as dermatofibrosarcoma protuberans. The tumor was surgically resected from a 72-year-old male Chinese Han patient, and pathological examination revealed spindle-shaped tumor cells with eosinophilic cytoplasm and an oval nucleus. Immunohistochemically, the tumor cells showed strong cytoplasmic positivity for CD34, c-KIT (CD117), and DOG1...
June 2017: Journal of International Medical Research
https://read.qxmd.com/read/28372349/perivascular-epithelioid-cell-tumor-in-the-stomach
#26
JOURNAL ARTICLE
Sun Ah Shin, Jiwoon Choi, Kyung Chul Moon, Woo Ho Kim
Perivascular epithelioid cell tumors or PEComas can arise in any location in the body. However, a limited number of cases of gastric PEComa have been reported. We present two cases of gastric PEComas. The first case involved a 62-year-old woman who presented with a 4.2 cm gastric subepithelial mass in the prepyloric antrum, and the second case involved a 67-year-old man with a 5.0 cm mass slightly below the gastroesophageal junction. Microscopic examination revealed that both tumors were composed of perivascular epithelioid cells that were immunoreactive for melanocytic and smooth muscle markers...
July 2017: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/28362703/an-epithelioid-gastrointestinal-stromal-tumor-of-the-stomach-with-strong-expression-of-keratin-clinicopathologic-correlation-and-follow-up-post-imatinib-therapy
#27
JOURNAL ARTICLE
Nick Baniak, Lawrence Lee, Chen Zhou, Sean Young, Darryl Yu
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the digestive tract. They are relatively rare neoplasms compared with gastrointestinal carcinomas and usually can readily be differentiated from carcinomas based on the morphology of the neoplastic cells that are typically spindled (70%), pure epithelioid, or mixed type. GISTs in general lack expression of cytokeratin and exhibit immunoreactivity toward CD117, CD34, or DOG1. GISTs can demonstrate a pure epithelioid morphology that can appear similar histologically to a carcinoma...
October 2019: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://read.qxmd.com/read/28356974/gastrointestinal-stromal-tumor-with-a-pdgfra-mutation-masquerading-as-gastric-plexiform-fibromyxoma-a-comparative-clinicopathological-study-of-two-cases
#28
JOURNAL ARTICLE
Jun Zhou, Jingjing Xu, Guozhong Jiang, Yihui Ma, Jingwen Qi, Wencai Li, Dandan Zhang
Gastric plexiform fibromyxoma (PF) is a rare mesenchymal tumor with a histologically distinctive multinodular pattern, dissimilar to conventional gastrointestinal stromal tumor (GIST). The current study presents one case of gastric PF, and one case of GIST with a platelet-derived growth factor receptor α ( PDGFRA ) mutation mimicking PF, and discusses their differential diagnoses. The two patients were a 51-year-old male with PF and a 47-year-old female with GIST, each of whom presented with an occupying lesion in the gastric antrum...
February 2017: Oncology Letters
https://read.qxmd.com/read/28288693/uterine-epithelioid-leiomyosarcoma-with-c-kit-expression-and-ywhae-gene-rearrangement-a-case-report-of-a-diagnostic-pitfall-of-uterine-sarcoma
#29
JOURNAL ARTICLE
Terufumi Kubo, Shintaro Sugita, Ryuichi Wada, Noriaki Kikuchi, Masahiro Iwasaki, Yumika Ito, Taro Sugawara, Hiromi Fujita, Makoto Emori, Ryoichi Tanaka, Hiroshi Hirano, Tsuyoshi Saito, Tadashi Hasegawa
BACKGROUND: Uterine sarcoma is a rare tumor that is often difficult to classify based on morphological and immunohistochemical analysis alone. Limited access to molecular biological analysis in routine practice would hinder making a definitive diagnosis. CASE PRESENTATION: In this report, we describe a case of a mesenchymal tumor arising from the uterine cervix in a 52-year-old woman. From microscopic morphology of the resected specimen, epithelioid leiomyosarcoma, high-grade endometrial stromal sarcoma, or uterine gastrointestinal stromal tumor (GIST) were considered as differential diagnoses...
March 14, 2017: Diagnostic Pathology
https://read.qxmd.com/read/27846844/a-rare-case-with-synchronous-gastric-gastrointestinal-stromal-tumor-pancreatic-neuroendocrine-tumor-and-uterine-leiomyoma
#30
JOURNAL ARTICLE
Elena Arabadzhieva, Atanas Yonkov, Sasho Bonev, Dimitar Bulanov, Ivanka Taneva, Alexandrina Vlahova, Tihomir Dikov, Violeta Dimitrova
BACKGROUND: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. CASE PRESENTATION: We describe an unusual case with triple tumor localization-a gastric tumor, a formation in the pancreas, which involves the retroperitoneal space, and a uterine leiomyoma...
November 15, 2016: World Journal of Surgical Oncology
https://read.qxmd.com/read/27842558/perivascular-epithelioid-cell-tumor-of-the-descending-colon-mimicking-a-gastrointestinal-stromal-tumor-a-case-report
#31
JOURNAL ARTICLE
Ryuta Iwamoto, Tatsuki R Kataoka, Ayako Furuhata, Kazuo Ono, Seiichi Hirota, Kenji Kawada, Yoshiharu Sakai, Hironori Haga
BACKGROUND: We present a case of perivascular epithelioid cell tumor (PEComa), which clinically and histologically mimics a gastrointestinal stromal tumor (GIST). CASE PRESENTATION: A 42-year-old woman was found to have a mass in the left flank during her annual medical checkup. Computed tomography examination revealed a submucosal tumor of the descending colon. Surgeons and radiologists suspected that the lesion was a GIST, and left hemicolectomy was performed without biopsy...
November 14, 2016: World Journal of Surgical Oncology
https://read.qxmd.com/read/26339433/perivascular-epithelioid-cell-tumor-in-the-duodenum-challenge-in-differential-diagnosis
#32
JOURNAL ARTICLE
Zehong Chen, Huijuan Shi, Jianjun Peng, Yujie Yuan, Jianhui Chen, Wu Song
Defined as a family of scarce mesenchymal neoplasm which distinctively co-express melanocytic markers and muscle markers, perivascular epithelioid cell tumors (PEComas) have been reported almost everybody site. Perivascular epithelioid cell tumors-not otherwise specified (PEComas-NOS) arising in the gastrointestinal (GI) tract are still restricted into sporadic case reports. Herein we present a case of GI PEComas-NOS which occurs in the duodenum of a 27-year-old male. Our initial diagnosis tended to gastrointestinal stromal tumor or smooth muscle tumor till the correct diagnosis of perivascular epithelioid cell tumor (PEComa) was established by postoperative pathological examination...
2015: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/26297059/diagnostically-challenging-epithelioid-soft-tissue-tumors
#33
REVIEW
Aaron W James, Sarah M Dry
In this article, we focus on the histologic features, differential diagnosis, and potential pitfalls in the diagnosis of epithelioid sarcoma, alveolar soft part sarcoma, clear-cell sarcoma, ossifying fibromyxoid tumor, and malignant extrarenal rhabdoid tumor. Numerous other soft tissue tumors also may have epithelioid variants or epithelioid features. Examples include epithelioid angiosarcoma, epithelioid malignant peripheral nerve sheath tumor, epithelioid gastrointestinal stromal tumor, and perivascular epithelioid cell tumor, among others...
September 2015: Surgical Pathology Clinics
https://read.qxmd.com/read/25724000/sox10-a-marker-for-not-only-schwannian-and-melanocytic-neoplasms-but-also-myoepithelial-cell-tumors-of-soft-tissue-a-systematic-analysis-of-5134-tumors
#34
JOURNAL ARTICLE
Markku Miettinen, Peter A McCue, Maarit Sarlomo-Rikala, Wojciech Biernat, Piotr Czapiewski, Janusz Kopczynski, Lester D Thompson, Jerzy Lasota, Zengfeng Wang, John F Fetsch
Sox10 transcription factor is expressed in schwannian and melanocytic lineages and is important in their development and can be used as a marker for corresponding tumors. In addition, it has been reported in subsets of myoepithelial/basal cell epithelial neoplasms, but its expression remains incompletely characterized. In this study, we examined Sox10 expression in 5134 human neoplasms spanning a wide spectrum of neuroectodermal, mesenchymal, lymphoid, and epithelial tumors. A new rabbit monoclonal antibody (clone EP268) and Leica Bond Max automation were used on multitumor block libraries containing 30 to 70 cases per slide...
June 2015: American Journal of Surgical Pathology
https://read.qxmd.com/read/25055264/imaging-and-clinicopathologic-features-of-esophageal-gastrointestinal-stromal-tumors
#35
JOURNAL ARTICLE
Abbey J Winant, Marc J Gollub, Jinru Shia, Christina Antonescu, Manjit S Bains, Marc S Levine
OBJECTIVE: The purpose of this article is to describe the imaging and clinicopathologic characteristics of esophageal gastrointestinal stromal tumors (GISTs) and to emphasize the features that differentiate esophageal GISTs from esophageal leiomyomas. MATERIALS AND METHODS: A pathology database search identified all surgically resected or biopsied esophageal GISTs, esophageal leiomyomas, and esophageal leiomyosarcomas from 1994 to 2012. Esophageal GISTs were included only if imaging studies (including CT, fluoroscopic, or (18)F-FDG PET/CT scans) and clinical data were available...
August 2014: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/24918465/cystic-gastrointestinal-stromal-tumors-of-the-pancreas-simulating-cystoadenocarcinoma-report-of-three-cases-and-short-review-of-the-literature
#36
REVIEW
M R Ambrosio, B J Rocca, M G Mastrogiulio, A Pesci, A De Martino, M A Mazzei, L Volterrani, F Arcuri, M Cintorino, S A Tripodi
Gastrointestinal stromal tumors (GISTs) represent a distinct subset of mesenchymal tumours of the gastrointestinal tract. They are more common in the stomach and small intestine, and are characterized by the proliferation of spindle or epithelioid cells and by the expression of CD117. Extra-gastrointestinal stromal tumors are rare and only 13 cases of pancreatic GISTs have been reported in the literature, only 1 of which presented as a cystic lesion. Mutational analysis of KIT and Platelet derived growth factor receptor-α genes was performed only in two out of the 13 cases...
December 2014: Histology and Histopathology
https://read.qxmd.com/read/24111893/immunohistochemistry-of-soft-tissue-tumours-review-with-emphasis-on-10-markers
#37
REVIEW
Markku Miettinen
Immunohistochemistry is an integral component in the proper analysis of soft tissue tumours, and a simple panel of six markers is useful in practical triage: CD34, desmin, epithelial membrane antigen (EMA), keratin cocktail AE1/AE3, S100 protein and alpha smooth muscle actin (SMA). These markers frequently assist in the differential diagnosis of fibroblastic, myoid, nerve sheath and perineurial cell tumours, synovial and epithelioid sarcoma and others. However, they all are multispecific, so that one has to be cognizant of their distribution in normal and neoplastic tissues...
January 2014: Histopathology
https://read.qxmd.com/read/24042513/a-resected-perivascular-epithelioid-cell-tumor-pecoma-of-the-pancreas-diagnosed-using-endoscopic-ultrasound-guided-fine-needle-aspiration
#38
REVIEW
Kosuke Okuwaki, Mitsuhiro Kida, Hironori Masutani, Hiroshi Yamauchi, Hiroyuki Katagiri, Tetuo Mikami, Shiro Miyazawa, Tomohisa Iwai, Miyoko Takezawa, Hiroshi Imaizumi, Wasaburo Koizumi
Primary perivascular epithelioid cell tumors (PEComas) of the pancreas are extremely rare. We herein report our experience with a patient who had a primary PEComa of the pancreas that was diagnosed by the preoperative histopathological examination of a biopsy specimen obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The patient was a 43-year-old woman whose chief complaint was abdominal pain. Imaging studies revealed a pancreatic tumor. Gastrointestinal stromal tumor (GIST), solid pseudopapillary tumor and neuroendocrine tumor were considered in the differential diagnosis...
2013: Internal Medicine
https://read.qxmd.com/read/23755839/gastrointestinal-stromal-tumors-in-children-and-young-adults-a-clinicopathologic-and-molecular-genetic-study-of-22-korean-cases
#39
JOURNAL ARTICLE
Guhyun Kang, Young Soo Park, Eun-Sun Jung, Mee Joo, Mi Seon Kang, Soomin Ahn, Gu Hyum Kang, Kyoung-Mee Kim
Studies on gastrointestinal stromal tumors (GISTs) in young patients are limited due to their rarity, and none have been conducted in Asian populations. GISTs from patients under the age of 30 were retrospectively reviewed and were analyzed for clinicopathologic features, immunohistochemistry for SDHB (succinate dehydrogenase subunit B), and mutations for exon 9, 11, 13, and 17 of KIT gene and exon 12, 14, and 18 of PDGFRA gene. We found two pediatric (<18 years old) and 20 young adult (18-30 years old) GIST cases...
October 2013: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/23489352/progress-in-molecular-diagnostics-of-gastrointestinal-stromal-tumors
#40
JOURNAL ARTICLE
Ondrej Daum, Tomas Vanecek, Zdenek Benes, Michal Michal
Gastrointestinal stromal tumor (GIST) is the most frequent mesenchymal tumor of the alimentary tract, presently being defined as a tumor composed of spindle and/or epithelioid cells presumably differentiating towards interstitial cells of Cajal. The most frequent location of gastrointestinal stromal tumor is the stomach, followed by other sites of gastrointestinal tract. Occasional sites of occurrence are mesenterium, omentum, retroperitoneum, gall bladder, urinary bladder, pancreas, prostate and the vagina...
November 2007: Expert Opinion on Medical Diagnostics
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