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https://www.readbyqxmd.com/read/28742845/evaluation-of-k-ras-and-p53-expression-in-pancreatic-adenocarcinoma-using-the-cancer-genome-atlas
#1
Liming Lu, Jingchun Zeng
Genetic alterations in K-ras and p53 are thought to be critical in pancreatic cancer development and progression. However, K-ras and p53 expression in pancreatic adenocarcinoma have not been systematically examined in The Cancer Genome Atlas (TCGA) Data Portal. Information regarding K-ras and p53 alterations, mRNA expression data, and protein/protein phosphorylation abundance was retrieved from The Cancer Genome Atlas (TCGA) databases, and analyses were performed by the cBioPortal for Cancer Genomics. The mutual exclusivity analysis showed that events in K-ras and p53 were likely to co-occur in pancreatic adenocarcinoma (Log odds ratio = 1...
2017: PloS One
https://www.readbyqxmd.com/read/28741642/fabricating-chiroptical-starfruit-like-au-nanoparticles-via-interface-modulation-of-chiral-thiols
#2
Jiao Yan, Yuandong Chen, Shuai Hou, Jiaqi Chen, Dejing Meng, Hui Zhang, Huizhen Fan, Yinglu Ji, Xiaochun Wu
The surface/interface matters as the size of materials enters the nanoscale. Control of surface/interface, therefore, plays an important role in creating novel nanostructures with unusual properties and in obtaining devices with high performance. Herein, we demonstrate unique interface regulation in fabricating nanostructures with strong plasmonic circular dichroism (PCD). With chiral cysteine (Cys) as surface-modulating molecules, starfruit-like Au nanoparticles (NPs) with high PCD responses are obtained via Au overgrowth on Au nanorods (AuNRs)...
July 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28739045/filamin-b-the-next-hotspot-in-skeletal-research
#3
REVIEW
Qiming Xu, Nan Wu, Lijia Cui, Zhihong Wu, Guixing Qiu
Filamin B (FLNB) is a large dimeric actin-binding protein which crosslinks actin cytoskeleton filaments into a dynamic structure. Up to present, pathogenic mutations in FLNB are solely found to cause skeletal deformities, indicating the important role of FLNB in skeletal development. FLNB-related disorders are classified as spondylocarpotarsal synostosis (SCT), Larsen syndrome (LS), atelosteogenesis (AO), boomerang dysplasia (BD), and isolated congenital talipes equinovarus, presenting with scoliosis, short-limbed dwarfism, clubfoot, joint dislocation and other unique skeletal abnormalities...
July 6, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28738305/contamination-characteristics-and-source-apportionment-of-methylated-pahs-in-agricultural-soils-from-yangtze-river-delta-china
#4
Weixiao Chen, Xinyi Wu, Haiyun Zhang, Jianteng Sun, Wenxin Liu, Lizhong Zhu, Xiangdong Li, Daniel C W Tsang, Shu Tao, Xilong Wang
Alkylated PAHs (APAHs) have been shown to be more toxic and persistent than their non-alkylated parent compounds. However, little is known about the extent of soil contamination by these pollutants. To help understand agricultural soil pollution by these compounds at a regional scale, a total of 18 methylated PAHs (MPAHs, a major class of APAHs) in 243 soil samples were analyzed. These soil samples were collected from 11 sites in the Yangtze River Delta (YRD) region, a representative fast developing area in China...
July 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28737894/dual-role-of-gold-nanorods-inhibition-dissolution-of-a%C3%AE-fibrils-induced-by-near-ir-laser
#5
Swathi Sudhakar, Poornima Budime Santhosh, Ethayaraja Mani
Extracellular plaques of amyloid beta (Aβ) fibrils and neurofibrillary tangles are known to be associated with neurological diseases such as Alzheimer's. Studies have shown that spherical nanoparticles inhibit the formation of Aβ fibrils by intercepting the nucleation and growth pathways of fibrillation. In this report, gold nanorods (AuNR) are used to inhibit the formation of Aβ fibrils and the shape-dependent plasmonic properties of AuNR are exploited to faciliate faster dissolution of mature Aβ fibrils...
July 24, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28737491/safeguarding-health-in-europe-s-migrant-hotspots
#6
Sally Hargreaves
No abstract text is available yet for this article.
July 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28736681/integrating-environmental-monitoring-and-mosquito-surveillance-to-predict-vector-borne-disease-prospective-forecasts-of-a-west-nile-virus-outbreak
#7
Justin K Davis, Geoffrey Vincent, Michael B Hildreth, Lon Kightlinger, Christopher Carlson, Michael C Wimberly
INTRODUCTION: Predicting the timing and locations of future mosquito-borne disease outbreaks has the potential to improve the targeting of mosquito control and disease prevention efforts. Here, we present and evaluate prospective forecasts made prior to and during the 2016 West Nile virus (WNV) season in South Dakota, a hotspot for human WNV transmission in the United States. METHODS: We used a county-level logistic regression model to predict the weekly probability of human WNV case occurrence as a function of temperature, precipitation, and an index of mosquito infection status...
May 23, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28736315/the-spectrum-of-triple-negative-breast-disease-high-and-low-grade-lesions
#8
REVIEW
Felipe C Geyer, Fresia Pareja, Britta Weigelt, Emad Rakha, Ian O Ellis, Stuart J Schnitt, Jorge S Reis-Filho
Triple-negative breast cancer is viewed clinically as an aggressive subgroup of breast cancer. In fact, the majority of triple-negative breast cancers are poor-prognosis tumors with a complex genomic landscape. However, triple-negative disease is vastly heterogeneous, encompassing multiple entities with marked genetic, transcriptional, histological, and clinical differences, with neoplasms in this group ranging from low- to high-grade. Among the less common low-grade triple-negative lesions, two large subgroups, both with a rather indolent behavior, can be distinguished: a low-grade triple-negative breast neoplasia family, which includes nonobligate precursors of triple-negative breast cancer, and, despite being low-grade, harbor the complex genomic landscape of usual triple-negative breast cancer, and the salivary gland-like tumors of the breast, lacking all of the cardinal molecular features of conventional triple-negative breast cancer and underpinned by specific fusion-genes or hotspot mutations, which may be of diagnostic and possibly therapeutic utility...
July 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28735482/design-and-application-of-multiplex-pcr-seq-for-the-detection-of-somatic-mutations-associated-with-myeloid-malignancies
#9
Naomi Park, George Vassiliou
Targeted sequencing, in which only a selected set of genomic loci are sequenced, enables a much higher coverage of each target than what is obtained using whole genome or exome sequencing. Multiplex PCR offers a simple and affordable technique for specific capture of target regions and can be easily adapted to generate next-generation sequencing (NGS)-ready amplicons. Here we describe a multiplex PCR (MxPCR) approach for capturing 13 leukemia-associated mutation hotspots followed by MiSeq sequencing that enables robust detection of mutations with a variant allele fraction (VAF) as low as 0...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28734266/air-quality-and-health-effects-of-biogenic-volatile-organic-compounds-emissions-from-urban-green-spaces-and-the-mitigation-strategies
#10
Yuan Ren, Zelong Qu, Yuanyuan Du, Ronghua Xu, Danping Ma, Guofu Yang, Yan Shi, Xing Fan, Akira Tani, Peipei Guo, Ying Ge, Jie Chang
Biogenic volatile organic compounds (BVOCs) emissions lead to fine particulate matter (PM2.5) and ground-level ozone pollution, and are harmful to human health, especially in urban areas. However, most BVOCs estimations ignored the emissions from urban green spaces, causing inaccuracies in the understanding of regional BVOCs emissions and their environmental and health effects. In this study, we used the latest local vegetation datasets from our field survey and applied an estimation model to analyze the spatial-temporal patterns, air quality impacts, health damage and mitigating strategies of BVOCs emissions in the Greater Beijing Area...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734110/when-can-refuges-mediate-the-genetic-effects-of-fire-regimes-a-simulation-study-of-the-effects-of-topography-and-weather-on-neutral-and-adaptive-genetic-diversity-in-fire-prone-landscapes
#11
Sam C Banks, Ian D Davies, Geoffrey J Cary
Understanding how landscape heterogeneity mediates the effects of fire on biodiversity is increasingly important under global changes in fire regimes. We used a simulation experiment to investigate how fire regimes interact with topography and weather to shape neutral and selection-driven genetic diversity under alternative dispersal scenarios, and to explore the conditions under which micro-refuges can maintain genetic diversity of populations exposed to recurrent fire. Spatial heterogeneity in simulated fire frequency occurred in topographically-complex landscapes, with fire refuges and fire-prone 'hotspots' apparent...
July 22, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28733590/hypersaline-sapropels-act-as-hotspots-for-microbial-dark-matter
#12
Adrian-Ştefan Andrei, Andreea Baricz, Michael Scott Robeson, Manuela Raluca Păuşan, Tudor Tămaş, Cecilia Chiriac, Edina Szekeres, Lucian Barbu-Tudoran, Erika Andrea Levei, Cristian Coman, Mircea Podar, Horia Leonard Banciu
Present-day terrestrial analogue sites are crucial ground truth proxies for studying life in geochemical conditions close to those assumed to be present on early Earth or inferred to exist on other celestial bodies (e.g. Mars, Europa). Although hypersaline sapropels are border-of-life habitats with moderate occurrence, their microbiological and physicochemical characterization lags behind. Here, we study the diversity of life under low water activity by describing the prokaryotic communities from two disparate hypersaline sapropels (Transylvanian Basin, Romania) in relation to geochemical milieu and pore water chemistry, while inferring their role in carbon cycling by matching taxa to known taxon-specific biogeochemical functions...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732398/simulation-of-targeted-pollutant-mitigation-strategies-to-reduce-nitrate-and-sediment-hotspots-in-agricultural-watershed
#13
Awoke Dagnew Teshager, Philip W Gassman, Silvia Secchi, Justin T Schoof
About 50% of U.S. water pollution problems are caused by non-point source (NPS) pollution, primarily sediment and nutrients from agricultural areas, despite the widespread implementation of agricultural Best Management Practices (BMPs). However, the effectiveness of implementation strategies and type of BMPs at watershed scale are still not well understood. In this study, the Soil and Water Assessment Tool (SWAT) ecohydrological model was used to assess the effectiveness of pollutant mitigation strategies in the Raccoon River watershed (RRW) in west-central Iowa, USA...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732052/protein-asparagine-deamidation-prediction-based-on-structures-with-machine-learning-methods
#14
Lei Jia, Yaxiong Sun
Chemical stability is a major concern in the development of protein therapeutics due to its impact on both efficacy and safety. Protein "hotspots" are amino acid residues that are subject to various chemical modifications, including deamidation, isomerization, glycosylation, oxidation etc. A more accurate prediction method for potential hotspot residues would allow their elimination or reduction as early as possible in the drug discovery process. In this work, we focus on prediction models for asparagine (Asn) deamidation...
2017: PloS One
https://www.readbyqxmd.com/read/28731050/genomic-abnormalities-in-invasive-endocervical-adenocarcinoma-correlate-with-pattern-of-invasion-biologic-and-clinical-implications
#15
Anjelica Hodgson, Yutaka Amemiya, Arun Seth, Matthew Cesari, Bojana Djordjevic, Carlos Parra-Herran
The pattern-based classification system for HPV-related endocervical adenocarcinoma, which classifies tumors based on the destructiveness of stromal invasion, is predictive of the risk of nodal metastases and adverse outcome. Previous studies have demonstrated clinically important molecular alterations in endocervical adenocarcinoma, including KRAS and PIK3CA mutations; however, correlation between the molecular landscape and pathological variables including pattern of invasion has not been thoroughly explored...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28730607/concurrent-chondrodysplasia-punctata-type-2-conradi-hunermann-happle-syndrome-and-ichthyosis-vulgaris-in-teenaged-twin-girls
#16
Haneol S Jeong, Tara Funari, Katherine Gordon, Gabriele Richard, Nnenna G Agim
We present concurrent X-linked chondrodysplasia punctata and ichthyosis vulgaris in adolescent fraternal twin girls, notable for initial presentation with dry skin in adolescence, characterized by dark-brown scale typical of ichthyosis vulgaris and blaschkolinear, atrophic, scaly plaques. This constellation of findings prompted further genetic investigation. Using a multigene approach to examine 39 genes associated with congenital ichthyosis, next-generation sequencing revealed a novel heterozygous missense mutation at a mutational hotspot in the EBP gene c...
July 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28728836/chromosome-intermingling-mechanical-hotspots-for-genome-regulation
#17
REVIEW
Caroline Uhler, G V Shivashankar
Cells sense physical and chemical signals from their local microenvironment and transduce them to the nucleus to regulate genomic programs. In this review, we first discuss different modes of mechanotransduction to the nucleus. We then highlight the role of the spatial organization of chromosomes for integrating these signals. In particular, we emphasize the importance of chromosome intermingling for gene regulation. We also discuss various geometric models and recent advances in microscopy and genomics that have allowed access to these nanoscale chromosome intermingling regions...
July 17, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/28728131/the-distribution-of-organochlorine-pesticides-in-sediments-from-isimangaliso-wetland-park-ecological-risks-and-implications-for-conservation-in-a-biodiversity-hotspot
#18
Archibold Buah-Kwofie, Marc S Humphries
The iSimangaliso Wetland Park World Heritage site, located on the east coast of South Africa, spans ∼3300 km(2) and constitutes the largest protected estuarine environment for hippopotami, crocodiles and aquatic birds in Africa. Given the ecological importance of this site and continued use of organochlorine pesticides (OCPs) in the region, this study focused on the nature, distribution and potential sources of organochlorine contamination within iSimangaliso Wetland Park. OCPs were widely distributed in surface sediment samples obtained from the four main Ramsar wetland systems within the park (Lake St Lucia, Mkhuze, Lake Sibaya and Kosi Bay)...
July 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28727847/outstanding-micro-endemism-in-new-caledonia-more-than-one-out-of-ten-animal-species-have-a-very-restricted-distribution-range
#19
Maram Caesar, Philippe Grandcolas, Roseli Pellens
New Caledonia is a biodiversity hotspot, with an extremely high number of endemic species with narrow distribution ranges that are at high risk of extinction due to open-cast nickel mining, invasive species and seasonal man-induced fires. Mentions of micro-endemism permeate the literature on the biota of this archipelago. However, so far there has been no research comparing distribution range in different animal groups. The aim of this study is to examine the implication of different sampling effort variables in order to distinguish micro-endemicity from data deficiency, and evaluate the distribution range, frequency, and extent to which micro-endemism is common to several groups of organisms...
2017: PloS One
https://www.readbyqxmd.com/read/28727786/is-there-a-relationship-between-geographic-distance-and-uptake-of-hiv-testing-services-a-representative-population-based-study-of-chinese-adults-in-guangzhou-china
#20
Wen Chen, Fangjing Zhou, Brian J Hall, Joseph D Tucker, Carl Latkin, Andre M N Renzaho, Li Ling
Achieving high coverage of HIV testing services is critical in many health systems, especially where HIV testing services remain centralized and inconvenient for many. As a result, planning the optimal spatial distribution of HIV testing sites is increasingly important. We aimed to assess the relationship between geographic distance and uptake of HIV testing services among the general population in Guangzhou, China. Utilizing spatial epidemiological methods and stratified household random sampling, we studied 666 adults aged 18-59...
2017: PloS One
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