Amanda Cristina Reis Gonzaga, Jayane Laís Dias Quintão, Giovane Galdino, Thiago Roberto Lima Romero, Grazielle Caroline da Silva, Virgínia Soares Lemos, Gabriel Henrique Campolina-Silva, Cleida Aparecida de Oliveira, Germán Arturo Bohórquez Mahecha, Igor Dimitri Gama Duarte
INTRODUCTION: Tissue injury results in the release of inflammatory mediators, including a cascade of algogenic substances, which contribute to the development of hyperalgesia. During this process, endogenous analgesic substances are peripherally released to counterbalance hyperalgesia. The present study aimed to investigate whether inflammatory mediators TNF-α, IL-1β, CXCL1, norepinephrine (NE) and prostaglandin E2 (PGE2) may be involved in the deflagration of peripheral endogenous modulation of inflammatory pain by activation of the cholinergic system...
April 20, 2024: Pharmacology