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https://www.readbyqxmd.com/read/29168860/raspberry-differentially-improves-age-related-declines-in-psychomotor-function-dependent-on-baseline-motor-ability
#1
Barbara Shukitt-Hale, Nopporn Thangthaeng, Megan E Kelly, Donald E Smith, Marshall G Miller
Among older adults, falls are a leading cause of distress, pain, injury, loss of confidence, and ultimately, loss of independence and death. Previous studies in our laboratory have demonstrated that berry supplementation improves the age-related declines in balance, muscle strength, and coordination that often lead to falls, even when initiated later in life. The purpose of this study was to explore the interaction between baseline motor performance and the daily intake of raspberry required to improve/preserve motor function...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168558/outcomes-in-women-undergoing-robotic-assisted-laparoscopic-hysterectomy-compared-to-conventional-laparoscopic-hysterectomy-at-a-tertiary-hospital-in-western-australia
#2
Vinita A Rajadurai, Jason Tan, Stuart G Salfinger, Paul A Cohen
BACKGROUND: Robotic-assisted laparoscopic hysterectomy (RALH) is associated with improved outcomes compared to open surgery in patients with endometrial cancer but data are conflicting when comparing RALH to conventional total laparoscopic hysterectomy (TLH). In October 2014, a RALH program was established in Perth, Western Australia. AIM: To compare outcomes in patients undergoing RALH with a matched cohort undergoing TLH. MATERIALS AND METHODS: A retrospective matched cohort study compared outcomes in 45 patients who underwent RALH with 45 controls who were patients treated with TLH...
November 23, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29168214/transdermal-light-neuromodulation-optogenetics-in-the-murine-urinary-tract
#3
Shannon L Wallace, Robert S Kelley, Shailja Mehta, Giannina Descalzi, John A Fantl, Charles Ascher-Walsh
BACKGROUND: Optogenetics is a biologic technique that uses light to control living neurons, which have been genetically modified to express light-sensitive ion-channels. OBJECTIVES: Using an adenovirus to modify the sciatic nerves of mice, we aim to demonstrate peripheral neuromodulation of bladder pain using transdermal light. STUDY DESIGN: This pilot study is divided into: A) Confirmation and Application and B) Behavioral Step. A) Six mice were injected with AAV6-hSyn-ChR2(H134R)-eYFP virus into their sciatic nerves...
November 23, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29168180/cxcr2-is-critical-for-bacterial-control-and-development-of-joint-damage-and-pain-in-staphylococcus-aureus-induced-septic-arthritis-in-mouse
#4
Daiane Boff, Vivian L S Oliveira, Celso M Queiroz Junior, Tarcília A Silva, Marcelo Allegretti, Waldiceu A Verri, Paul Proost, Mauro M Teixeira, Flavio A Amaral
Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrophils have an important function in controlling bacterial burden. This work aimed to study the role of CXCR2 in the control of infection, hypernociception and tissue damage in S. aureus-induced septic arthritis in mice...
November 22, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29168037/efficacy-and-safety-of-reinfusion-of-concentrated-ascitic-fluid-for-malignant-ascites-a-concept-proof-study
#5
Rumi Hanada, Naosuke Yokomichi, Chihiro Kato, Kazumi Miki, Sachiko Oyama, Tatsuya Morita, Ryoko Kawahara
PURPOSE: Malignant ascites is one of the symptoms causing discomfort in advanced cancer patients. Cell-free and concentrated ascites reinfusion therapy (CART) is one treatment modality, but controlled trials are limited. The primary aim of this study was to explore the efficacy and safety of CART, as well as their predictors, to obtain data for planning a further controlled trial. METHODS: This was a single center retrospective cohort study in patients with refractory malignant ascites...
November 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29167974/long-term-outcome-of-vaginal-mesh-or-native-tissue-in-recurrent-prolapse-a-randomized-controlled-trial
#6
Alfredo L Milani, Anne Damoiseaux, Joanna IntHout, Kirsten B Kluivers, Mariella I J Withagen
INTRODUCTION AND HYPOTHESIS: Our aim was to evaluate clinically relevant long-term outcomes of transvaginal mesh or native tissue repair in women with recurrent pelvic organ prolapse (POP). METHODS: We performed a 7-year follow-up of a randomized controlled trial on trocar-guided mesh placement or native tissue repair in women with recurrent POP. Primary outcome was composite success, defined as absence of POP beyond the hymen, absence of bulge symptoms, and absence of retreatment for POP...
November 22, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29167604/lumbar-facet-joint-injection-in-treating-low-back-pain-radiofrequency-denervation-versus-sham-procedure-systematic-review
#7
Munnan Al-Najjim, Rohit Shah, Mahmoud Rahuma, Omar Abdul Gabbar
The lumbar facet joints have been implicated as one of the causes of low-back pain syndromes. About 15-40% of patients who presented with chronic low-back pain was attributed to lumbar facet joint pain. The purpose of this study was to analyse whether radiofrequency denervation is better than SHAM procedure in treating chronic low-back pain caused by lumbar zygapophysial joints pathology. From the four identified randomised control trials, there is conflicting evidence at an intermediate 3-6-month stage, however; one study demonstrates statistical significance of radiofrequency denervation at 3 months...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29167518/encoding-of-menstrual-pain-experience-with-theta-oscillations-in-women-with-primary-dysmenorrhea
#8
Pin-Shiuan Lee, Intan Low, Yong-Sheng Chen, Cheng-Hao Tu, Hsiang-Tai Chao, Jen-Chuen Hsieh, Li-Fen Chen
Theta oscillation (4-7 Hz) is well documented for its association with neural processes of memory. Pronounced increase of theta activity is commonly observed in patients with chronic neurogenic pain. However, its association with encoding of pain experience in patients with chronic pain is still unclear. The goal of the present study is to investigate the theta encoding of sensory and emotional information of long-term menstrual pain in women with primary dysmenorrhea (PDM). Forty-six young women with PDM and 46 age-matched control subjects underwent resting-state magnetoencephalography study during menstrual and periovulatory phases...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167404/a-critical-role-for-dopamine-d5-receptors-in-pain-chronicity-in-male-mice
#9
Salim Megat, Stephanie Shiers, Jamie K Moy, Paulino Barragan-Iglesias, Grishma Pradhan, Rebecca P Seal, Gregory Dussor, Theodore J Price
Dopaminergic modulation of spinal cord plasticity has long been recognized but circuits affected by this system and the precise receptor subtypes involved in this modulation have not been defined. Dopaminergic modulation from the A11 nucleus of the hypothalamus contributes to plasticity in a model of chronic pain called hyperalgesic priming. Here we tested the hypothesis that the key receptor subtype mediating this effect is the D5 receptor (D5R). We find that a spinally-directed lesion of dopaminergic neurons reverses hyperalgesic priming in both sexes and that a D1/D5 antagonist transiently inhibits neuropathic pain...
November 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29167300/respiratory-adverse-effects-of-opioids-for-breathlessness-a-systematic-review-and-meta-analysis
#10
Cindy A Verberkt, Marieke H J van den Beuken-van Everdingen, Jos M G A Schols, Sushma Datla, Carmen D Dirksen, Miriam J Johnson, Sander M J van Kuijk, Emiel F M Wouters, Daisy J A Janssen
Previous studies have shown that opioids can reduce chronic breathlessness in advanced disease. However, physicians remain reluctant to prescribe opioids for these patients, commonly due to fear of respiratory adverse effects. The aim of this study was to systematically review reported respiratory adverse effects of opioids in patients with advanced disease and chronic breathlessness.PubMed, Embase, the Cochrane Central Register of Controlled Trials, CINAHL, ClinicalTrials.gov and the reference lists of relevant systematic reviews were searched...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29167092/dry-needling-for-patients-with-neck-pain-protocol-of-a-randomized-clinical-trial
#11
Eric Robert Gattie, Joshua A Cleland, Suzanne J Snodgrass
BACKGROUND: Neck pain is a costly and common problem. Current treatments are not adequately effective for a large proportion of patients who continue to experience recurrent pain. Therefore, new treatment strategies should be investigated in an attempt to reduce the disability and high costs associated with neck pain. Dry needling is a technique in which a fine needle is used to penetrate the skin, subcutaneous tissues, and muscle with the intent to mechanically disrupt tissue without the use of an anesthetic...
November 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29167074/effects-of-thermomechanical-stimulation-during-vaccination-on-anxiety-pain-and-satisfaction-in-pediatric-patients-a-randomized-controlled-trial
#12
Roberta E Redfern, John T Chen, Stephanie Sibrel
PURPOSE: Vaccination can be a significant source of pain for pediatric patients, which could result in fear of medical procedures and future reluctance to seek medical care. It is important for nurses to provide pain prevention during these procedures. This study sought to measure the impact of an intervention combining cold and vibration on pain scores during routine pediatric immunization. DESIGN AND METHODS: A prospective, open-label, randomized controlled trial to examine the effectiveness of the Buzzy device (thermomechanical stimulation) compared to no intervention (control group) in reducing child-reported pain during routine immunization...
September 28, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29167071/therapeutic-response-analysis-in-dogs-with-naturally-occurring-osteoarthritis
#13
Alexandre Gagnon, Dominique Brown, Maxim Moreau, Bertrand Lussier, Colombe Otis, Eric Troncy
OBJECTIVE: Reporting the rate of positive (+) and negative (-) responders based on an objective outcome measure of pain-related functional disability/lameness in dogs with naturally occurring osteoarthritis (OA), and the relationship between initial lameness severity and the odds of being a (+) responder. STUDY DESIGN: Retrospective analysis of published peer-reviewed clinical trials in dogs with naturally occurring OA. ANIMALS: Dogs (n = 213) with hip and/or stifle afflicted-joints...
September 15, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29167064/the-effect-of-adjuvant-chemotherapy-on-symptom-burden-and-quality-of-life-over-time-a-preliminary-prospective-observational-study-using-individual-data-of-patients-aged-%C3%A2-70-with-early-stage-invasive-breast-cancer
#14
Chantal Quinten, C Kenis, M Hamaker, A Coolbrandt, B Brouwers, L Dal Lago, P Neven, P Vuylsteke, G Debrock, H Van Den Bulck, A Smeets, P Schöffski, A Bottomley, U Wedding, H Wildiers
OBJECTIVES: We aim to assess short and long term effects of chemotherapy on patient-reported quality of life (QOL) and patient versus clinician symptom reporting in older patients with breast cancer adjusted for tumour and aging parameters. MATERIAL AND METHODS: In this prospective, multicentre, non-interventional, observational study, women aged ≥70years were enrolled after surgery and assigned to a TC chemotherapy (docetaxel and cyclophosphamide) group or a control group depending on their planned adjuvant treatment...
November 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29167050/insecure-attachment-style-and-cumulative-traumatic-life-events-in-patients-with-somatoform-pain-disorder-a-cross-sectional-study
#15
Yeliz Nacak, Eva Morawa, Daniela Tuffner, Yesim Erim
OBJECTIVE: Current models assume somatoform pain disorder (SPD) to be the result of a complex interaction between bio- and psychosocial factors, but the etiology is still not well understood. This study aimed to investigate the distribution of attachment style and the frequency of traumatic life events, especially childhood adversities, in patients with SPD compared to healthy controls. METHODS: We compared 65 patients with SPD (confirmed by Structured Clinical Interview, SCID-I) to 65 age- and gender-matched healthy controls...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29166893/the-effectiveness-of-interventions-aimed-at-increasing-physical-activity-in-adults-with-persistent-musculoskeletal-pain-a-systematic-review-and-meta-analysis
#16
Joanne Marley, Mark A Tully, Alison Porter-Armstrong, Brendan Bunting, John O'Hanlon, Lou Atkins, Sarah Howes, Suzanne M McDonough
BACKGROUND: Individuals with persistent musculoskeletal pain (PMP) have an increased risk of developing co-morbid health conditions and for early-mortality compared to those without pain. Despite irrefutable evidence supporting the role of physical activity in reducing these risks; there has been limited synthesis of the evidence, potentially impacting the optimisation of these forms of interventions. This review examines the effectiveness of interventions in improving levels of physical activity and the components of these interventions...
November 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29166890/continuous-passive-motion-and-physical-therapy-cpm-versus-physical-therapy-pt-versus-delayed-physical-therapy-dpt-after-surgical-release-for-elbow-contractures-a-study-protocol-for-a-prospective-randomized-controlled-trial
#17
Jetske Viveen, Job N Doornberg, Izaak F Kodde, Pjotr Goossens, Koen L M Koenraadt, Bertram The, Denise Eygendaal
BACKGROUND: The elbow is prone to stiffness after trauma. To regain functional elbow motion several conservative- and surgical treatment options are available. Conservative treatment includes physical therapy, intra-articular injections with corticosteroids and a static progressive or dynamic splinting program. If conservative treatment fails, an operative release of the posttraumatic stiff elbow is often performed. The best Evidence-Based rehabilitation protocol for patients after an operative release is unknown to date and differs per surgeon, hospital and country...
November 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29166883/the-humanistic-burden-of-pompe-disease-are-there-still-unmet-needs-a-systematic-review
#18
Benedikt Schoser, Deborah A Bilder, David Dimmock, Digant Gupta, Emma S James, Suyash Prasad
BACKGROUND: Humanistic burden considers the impact of an illness on a patient's health-related quality of life (HRQoL), activities of daily living (ADL), caregiver health, and caregiver QoL. Humanistic burden also considers treatment satisfaction and adherence to treatment regimens. Pompe disease is an autosomal recessive, progressive, multisystemic neuromuscular disease. Approval of enzyme-replacement therapy (ERT) markedly improved prognosis for patients, but considerable morbidity and a substantial humanistic burden remain...
November 22, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29166854/a-single-dose-of-dezocine-suppresses-emergence-agitation-in-preschool-children-anesthetized-with-sevoflurane-remifentanil
#19
Li-Jun An, Yang Zhang, Zheng Su, Xian-Long Zhang, Hai-Lin Liu, Zhi-Jie Zhang, Jian-Lin Hu, Shi-Tong Li
BACKGROUND: Emergence agitation (EA) is a common phenomenon in preschool children during emergence from general anesthesia. This study evaluated the safety and efficacy of dezocine for emergence agitation in preschool children anesthetized with sevoflurane-remifentanil. METHODS: A total of 100 preschool children, scheduled for elective laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia were randomized into two groups: Group C (n = 50) received Ringer's lactate 10 mL and Group D received Ringer's lactate 10 mL containing dezocine 0...
November 22, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29166347/prepectoral-breast-reconstruction-the-breast-surgeon-s-perspective
#20
Toni Storm-Dickerson, Noemi Sigalove
Prepectoral breast reconstruction has been reemerging as a technique for postmastectomy implant-based reconstruction. Due to its advantage in eliminating animation deformity, shortening length of hospital stay and decreasing the amount of narcotics used for pain control, the technique has been embraced by patients and surgeons alike. The authors examined the breast surgeon's perspective regarding prepectoral reconstruction taking into consideration oncologic criteria, breast cancer recurrence, surgical technique, and the team approach to patient care...
December 2017: Plastic and Reconstructive Surgery
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