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https://www.readbyqxmd.com/read/29046759/copper-deficiency-a-new-triad-anemia-leucopenia-and-myeloneuropathy
#1
Shoaib M Wazir, Ibrahim Ghobrial
Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate referral for bone marrow transplantation. Other conditions with similar presentations include infections, drug toxicity, autoimmunity, B12 deficiency, folate deficiency, myelodysplastic syndrome, aplastic anemia, and lymphoma with bone marrow involvement...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29046748/%C3%AE-thalassemia-minor-carbohydrate-malabsorption-and-histamine-intolerance
#2
Wolfgang J Schnedl, Michael Schenk, Sonja Lackner, Sandra J Holasek, Harald Mangge
Background: β-thalassemia minor is characterized by reduced β-haemoglobin chain synthesis and sometimes mild anaemia, although carriers of β-thalassemia minorare usually clinically asymptomatic.Nonspecific abdominal complaints may be caused by gastrointestinal carbohydrate malabsorption (lactose and fructose) and/or malabsorption of biogenic amines (histamine), or proteins (gluten). Objectives: We report on two patients with β-thalassemia minor suffering nonspecific abdominal symptoms due to a carbohydrate and histamine malabsorption...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29042668/signalling-mechanisms-in-paf-induced-intestinal-failure
#3
Ingmar Lautenschläger, Yuk Lung Wong, Jürgen Sarau, Torsten Goldmann, Karina Zitta, Martin Albrecht, Inéz Frerichs, Norbert Weiler, Stefan Uhlig
Capillary leakage syndrome, vasomotor disturbances and gut atony are common clinical problems in intensive care medicine. Various inflammatory mediators and signalling pathways are involved in these pathophysiological alterations among them platelet-activating factor (PAF). The related signalling mechanisms of the PAF-induced dysfunctions are only poorly understood. Here we used the model of the isolated perfused rat small intestine to analyse the role of calcium (using calcium deprivation, IP-receptor blockade (2-APB)), cAMP (PDE-inhibition plus AC activator), myosin light chain kinase (inhibitor ML-7) and Rho-kinase (inhibitor Y27632) in the following PAF-induced malfunctions: vasoconstriction, capillary and mucosal leakage, oedema formation, malabsorption and atony...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035975/breath-hydrogen-testing-in-east-and-southeast-asia
#4
Chu Kion Yao, Natural Hoi Sing Chu, Victoria Ping Yi Tan
Breath hydrogen tests are popular, noninvasive tests for the assessment of carbohydrate fermentation in patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). There is limited information regarding the utility of breath hydrogen and methane tests in IBS and FD patients in East and Southeast Asia. This review aims to summarize current literature about common indications of breath testing in this region, the genesis of functional gastrointestinal symptoms by provocative breath testing and provide suggestions for correct use...
October 13, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29034989/neurological-presentations-revealing-acquired-copper-deficiency-diagnosis-features-etiologies-and-evolution-in-seven-patients
#5
Aurélia Poujois, Nouzha Djebrani-Oussedik, Fabienne Ory-Magne, France Woimant
BACKGROUND: acquired copper deficiency (ACD) is a rare condition usually diagnosed from haematological changes. AIMS: characterize the diagnosis features and the evolution of patients with ACD revealed by neurological symptoms. METHODS: clinical, biological and MRI data were prospectively analysed at diagnosis and during follow-up under copper supplementation. RESULTS: seven patients were studied over a 5-year period...
October 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29029893/the-prevalence-of-sarcopenia-is-markedly-increased-in-patients-with-intestinal-failure-and-associates-with-several-risk-factors
#6
Anders Skallerup, Louis Nygaard, Søren Schou Olesen, Marianne Køhler, Lars Vinter-Jensen, Henrik Højgaard Rasmussen
BACKGROUND & AIMS: Intestinal insufficiency and intestinal failure are conditions associated with malabsorption of micro- and macronutrients. Consequently, malnutrition and ensuing alterations in body composition are common in this context and patients may have an increased risk of progressive loss of skeletal muscle mass and function (i.e. sarcopenia). We investigated the prevalence of sarcopenia in patients with intestinal insufficiency and intestinal failure and identified associated risk factors...
September 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29021363/novel-and-unexpected-functions-of-sglts
#7
REVIEW
Ernest M Wright, Chiara Ghezzi, Donald D F Loo
It has been 30 years since the intestinal sodium glucose cotransporter SGLT1 was cloned, and, in the intervening years, there have been many advances that have influenced physiology and medicine. Among the first was that SGLT1 is the founding member of the human gene family SLC5, containing 11 diverse transporters and a glucose sensor. Equally surprising was that SGLTs are members of a structural family of cotransporters and exchangers in different gene families. This led to the conclusion that these proteins operate by a mechanism where transport involves the opening and closing of external and internal gates...
November 2017: Physiology
https://www.readbyqxmd.com/read/29020456/the-management-of-neuroendocrine-tumors-a-nutritional-viewpoint
#8
Marco Gallo, Giovanna Muscogiuri, Genoveffa Pizza, Rosaria Maddalena Ruggeri, Luigi Barrea, Antongiulio Faggiano, Annamaria Colao
Nutritional status in patients with neuroendocrine tumours (NETs), especially of gastroenteropancreatic origin, can be deeply affected by excessive production of gastrointestinal hormones, peptides, and amines, which can lead to malabsorption, diarrhoea, steatorrhea, and altered gastrointestinal motility. Besides, the surgical and/or medical management of NETs can lead to alteration of gastrointestinal secretory, motor, and absorptive functions, with both dietary and nutritional consequences. Indeed, disease-related malnutrition is a frequently encountered yet both underrecognized and understudied clinical phenomenon in patients with NETs, with substantial prognostic and socioeconomic consequences...
October 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29016294/environmental-enteric-dysfunction-a-case-definition-for-intervention-trials
#9
Donna M Denno, Phillip I Tarr, James P Nataro
Environmental Enteric Dysfunction (EED) was first described as a malabsorption syndrome with small intestinal villous flattening among healthy adults in Thailand and other low-resource settings.(1-4) A similar entity was described in Peace Corps volunteers in South Asia.(5,6) Several years later, resolution of histopathology and malabsorption after repatriation or immigration to North America was demonstrated.(7,8).
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994566/sorbitol-malabsorption-in-patients-with-abdominal-discomfort
#10
Birgit Klee, Oliver Barske, Andrea Mack, Christoph K Thoeringer, Bernhard Haller, Valentin Becker, Simon Nennstiel
BACKGROUND: The role of sorbitol malabsorption in patients with functional abdominal discomfort has not been finally clarified yet. Therefore, aim of this study was to evaluate the clinical significance of sorbitol malabsorption, diagnosed by sorbitol hydrogen breath testing in these patients. METHODS: Data of all patients referred to our hospital for hydrogen breath testing between May, 1st 2013 and December 31st, 2014 were retrospectively collected and analyzed...
October 9, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28986026/nutrition-prevention-and-management-of-nutritional-failure-in-cystic-fibrosis
#11
Jillian S Sullivan, Maria R Mascarenhas
Close monitoring of nutritional status is critical to the overall health of a patient with CF. As part of routine CF care, measurement of weight and height (and calculation of weight/length or BMI as appropriate) should be performed and analyzed at each visit. Early recognition of nutritional risk is imperative and evaluation with a multidisciplinary team should be performed to assess for caloric intake, caloric malabsorption, and other causes of poor weight gain and growth. Many tools are available to use for intervention, including oral supplementation, behavioral interventions, medications, nutritional therapies, and enteral tube feeding...
September 16, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28985287/bariatric-surgery-and-hypertension
#12
Jonathan G Owen, Farshid Yazdi, Efrain Reisin
Obesity continues to increase in prevalence worldwide. Hypertension has long been associated with obesity, and weight loss continues to be a first-line therapy in the treatment of hypertension. Lifestyle modification and pharmacologic therapy, however, often meet with treatment failure. Bariatric surgery continues to be the most successful approach to sustained weight loss. This review focuses on the underlying physiologic mechanisms of obesity-hypertension, and the impact of bariatric surgery on the treatment of hypertension...
August 11, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28979239/severe-hypothyroidism-due-to-the-loss-of-therapeutic-efficacy-of-l-thyroxine-in-a-patient-with-esophageal-complication-associated-with-systemic-sclerosis
#13
Antonio Lobasso, Liliana Nappi, Letizia Barbieri, Carmela Peirce, Serena Ippolito, Debora Arpaia, Francesca Wanda Rossi, Amato de Paulis, Bernadette Biondi
BACKGROUND: Thyroid function abnormalities and thyroid autoantibodies have been frequently described in patients with systemic autoimmune diseases as systemic sclerosis (SSc). Serum TSH levels are higher in SSc patients with more severe skin diseases and a worse modified Rodnan skin score. Asymptomatic esophageal involvement due to SSc has never been described as a cause of severe hypothyroidism due to l-thyroxine (l-T4) malabsorption in patients with Hashimoto's thyroiditis (HT) and SSc...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28974589/the-efficacy-of-a-low-fat-diet-to-manage-the-symptoms-of-bile-acid-malabsorption-outcomes-in-patients-previously-treated-for-cancer
#14
Amy Jackson, Amyn Lalji, Mohammed Kabir, Ann Muls, Caroline Gee, Susan Vyoral, Clare Shaw, H Jervoise N Andreyev
Dietary fat ingestion triggers bile secretion into the gastrointestinal tract. Bile acid malabsorption affects >1% of the population, causing loose stool and other gastrointestinal symptoms. The diagnosis is frequently missed. Treatments are often considered ineffective. We evaluated low-fat diets for managing gastrointestinal symptoms in these patients. All patients reporting type 6 or 7 stool were offered a selenium-75 homocholic acid taurine (SeHCAT) scan. Prospective data in patients with 7-day scan retention <20% were analysed...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28974222/treating-tuberculosis-with-high-doses-of-anti-tb-drugs-mechanisms-and-outcomes
#15
REVIEW
Yuhui Xu, Jianan Wu, Sha Liao, Zhaogang Sun
Tuberculosis (TB) is considered as one of the most serious threats to public health in many parts of the world. The threat is even more severe in the developing countries where there is a lack of advanced medical amenities and contemporary anti-TB drugs. In such situations, dosage optimization of existing medication regimens seems to be the only viable option. Therapeutic drug monitoring study results suggest that high-dose treatment regimens can compensate the low serum concentration of anti-TB drugs and shorten the therapy duration...
October 3, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28974086/renal-disease-in-patients-with-celiac-disease-a-review
#16
Boonphiphop Boonpheng, Wisit Cheungpasitporn, Karn Wijarnpreecha
Celiac disease, an inflammatory disease of small bowel caused by sensitivity to dietary gluten and related protein, affects approximately 0.5-1% of the population in the Western world. Extraintestinal symptoms and associated diseases are increasingly recognized including diabetes mellitus type 1, thyroid disease, dermatitis herpetiformis and ataxia. There have also been a number of reports of various types of renal involvement in patients with celiac disease including diabetes nephropathy, IgA nephropathy, membranous nephropathy, membranoproliferative glomerulonephritis, nephrotic syndrome related to malabsorption, oxalate nephropathy, and associations of celiac disease with chronic kidney disease and end-stage kidney disease...
October 3, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28971174/investigation-of-celiac-disease-followed-by-immune-thrombocytopenic-purpura-diagnosis-in-patients-and-comparison-with-literature
#17
Hakan Sarbay, Halil Kocamaz, Mehmet Akin, Bayram Ozhan
OBJECTIVE: Celiac disease (CD) and Immune thrombocytopenic purpura (ITP) may occur together as a result of similar autoimmune mechanisms. The aim of this study was to assess the frequency of CD in a group of ITP patients and in the literature. METHODS: A total of 29 patients in Pamukkale University Faculty of Medicine Hospital Pediatric Hematology and Oncology Department with ITP were included in the study. Test was performed for the antibodies related to CD. Positive result for celiac antibodies was confirmed with biopsy...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28965810/assessment-of-tryptophan-metabolism-and-signs-of-depression-in-individuals-with-carbohydrate-malabsorption
#18
Dietmar Enko, Helga Wagner, Gernot Kriegshäuser, Wolfgang Brandmayr, Gabriele Halwachs-Baumann, Wolfgang J Schnedl, Sieglinde Zelzer, Harald Mangge, Andreas Meinitzer
This prospective cross-sectional study aimed to investigate the potential association between primary-adult lactose malabsorption, fructose malabsorption, tryptophan (TRP) metabolism and the presence of depressive signs. Overall 251 patients, who were referred for lactase gene C/T-13910 polymorphism genotyping and fructose hydrogen/methane breath testing, were included. All participants filled out the Beck Depression Inventory (BDI II). Serum concentrations of tryptophan (TRP), kynurenine (KYN), kynuric acid (KYNA), and TRP competing amino acids (leucine, isoleucine, valine, phenylalanine, tyrosine) were measured by high-pressure liquid-chromatography...
September 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28965570/oral-copper-absorption-in-men-with-morbid-obesity
#19
Joseph Boullata, Geetha Muthukumaran, Amanda Piarulli, John Labarre, Charlene Compher
Copper deficiency has been reported in patients with severe obesity, both before and after bariatric surgery, the latter at increased rates. However, little is known about the absorption of copper. Because of differences in copper dynamics between men and women in the limited available data, we evaluated copper absorption in men who were candidates for bariatric surgery. All patients gave informed consent, approved by the University of Pennsylvania Institutional Review Board, to participate in a pharmacokinetics study...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28965167/laparoscopic-reversal-of-the-biliopancreatic-diversion-with-duodenal-switch-a-step-by-step-video-case
#20
Hamzeh M Halawani, Gintaras Antanavicius
BACKGROUND: Despite the success of the Biliopancreatic Diversion with Duodenal Switch procedure (BPD-DS) in weight loss and comorbidities resolution, reversal of BPD-DS is necessary in 0.2-0.6% of BPD-DS cases for vitamin, protein, and other micronutrient deficiencies. Different techniques are available to reverse the malabsorptive component of the BPD-DS. METHODS: A retrospective chart review for a 37-year-old female patient who presented with lower leg edema and signs of malnutrition 5 years after a BPD/DS...
September 30, 2017: Obesity Surgery
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