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https://www.readbyqxmd.com/read/28078798/systematic-review-with-meta-analysis-rifaximin-is-effective-and-safe-for-the-treatment-of-small-intestine-bacterial-overgrowth
#1
REVIEW
L Gatta, C Scarpignato
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is a heterogeneous syndrome, characterised by an increased number and/or abnormal type of bacteria in the small bowel. Over the past decades, rifaximin has gained popularity for this indication despite its use is not evidence based. AIM: To perform a systematic review and meta-analysis to summarise evidence about the efficacy and safety of rifaximin to eradicate SIBO in adult patients. METHODS: MEDLINE, EMBASE, CCRCT, Scopus and Web of Science were searched from inception to March 16, 2015 for RCTs and observational studies...
January 12, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28030512/risk-of-small-intestinal-bacterial-overgrowth-with-chronic-use-of-proton-pump-inhibitors-in-children
#2
Kristen Cares, Namir Al-Ansari, Suhasini Macha, Najeeb Zoubi, Hazim Zaghloul, Ron Thomas, Patricia Lalinsky, Mohammad El-Baba
BACKGROUND: Some theorize that prolonged use of proton pump inhibitors (PPIs) may increase the risk of small intestinal bacterial overgrowth (SIBO). Chronic acid suppression and resultant hypochlorhydria may lead to an altered intraluminal environment, which, in turn, may promote the growth of bacteria in the small intestine. A handful of studies measured the risk of SIBO in adults taking PPIs and obtained mixed results; however, this risk has not been exclusively measured in children...
December 27, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28013205/clinical-correlates-of-faecal-incontinence-in-systemic-sclerosis-identifying-therapeutic-avenues
#3
Nicolas Richard, Marie Hudson, Geneviève Gyger, Murray Baron, Evelyn Sutton, Nader Khalidi, Janet E Pope, Nathalie Carrier, Maggie Larché, Alexandra Albert, Paul R Fortin, Carter Thorne, Ariel Masetto
OBJECTIVES: The aim was to establish the prevalence and severity of faecal incontinence (FI) in SSc, its association with other intestinal manifestations and potential predictors of FI, and its impact on quality of life. METHODS: A multicentre, cross-sectional study of 298 SSc subjects followed in the Canadian Scleroderma Research Group cohort was performed using validated questionnaires: Jorge-Wexner score (an FI severity scale), Bristol stool scale (a visual scale of stool consistency) and FI Quality-of-Life scale...
December 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/27974895/survivin-improves-reprogramming-efficiency-of-human-neural-progenitors-by-single-molecule-oct4
#4
Shixin Zhou, Yinan Liu, Ruopeng Feng, Caiyun Wang, Sibo Jiang, Xiaoyan Zhang, Feng Lan, Yang Li
Induced pluripotent stem (iPS) cells have been generated from human somatic cells by ectopic expression of four Yamanaka factors. Here, we report that Survivin, an apoptosis inhibitor, can enhance iPS cells generation from human neural progenitor cells (NPCs) together with one factor OCT4 (1F-OCT4-Survivin). Compared with 1F-OCT4, Survivin accelerates the process of reprogramming from human NPCs. The neurocyte-originated induced pluripotent stem (NiPS) cells generated from 1F-OCT4-Survivin resemble human embryonic stem (hES) cells in morphology, surface markers, global gene expression profiling, and epigenetic status...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27966357/coupled-nitrification-denitrification-caused-by-suspended-sediment-sps-in-rivers-importance-of-sps-size-and-composition
#5
Xinghui Xia, Zhimei Jia, Ting Liu, Sibo Zhang, Liwei Zhang
Suspended sediment (SPS) is ubiquitous in rivers, and SPS with different particle sizes and compositions may affect coupled nitrification-denitrification (CND) occurring on SPS significantly. However, there is no related research report. In this work, (15)N isotope tracer technique was adopted to explore the CND in systems containing SPS (8 g L(-1) and 1 g L(-1)) collected from the Yellow River with various particle sizes, including <2, 2-20, 20-50, 50-100, and 100-200 μm. The results showed that the CND occurred on SPS and the CND rate was negatively related to particle size; both nitrification and denitrification rate constants increased with decreasing SPS particle size...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27965476/positive-glucose-breath-tests-in-patients-with-hysterectomy-gastrectomy-and-cholecystectomy
#6
Dae Bum Kim, Chang-Nyol Paik, Yeon Ji Kim, Ji Min Lee, Kyong-Hwa Jun, Woo Chul Chung, Kang-Moon Lee, Jin-Mo Yang, Myung-Gyu Choi
Background/Aims: This study aimed to investigate the prevalence and characteristics of small intestinal bacterial overgrowth (SIBO) in patients undergoing abdominal surgeries, such as gastrectomy, cholecystectomy, and hysterectomy. Methods: One hundred seventy-one patients with surgery (50 hysterectomy, 14 gastrectomy, and 107 cholecystectomy), 665 patients with functional gastrointestinal disease (FGID) and 30 healthy controls undergoing a hydrogen (H₂)-methane (CH₄) glucose breath test (GBT) were reviewed...
December 16, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27934932/expression-profiling-and-functional-annotation-of-noncoding-genes-across-11-distinct-organs-in-rat-development
#7
Zhuo Wen, Geng Chen, Sibo Zhu, Jinhang Zhu, Bin Li, Yunjie Song, Suqing Li, Leming Shi, Yuanting Zheng, Menglong Li
Accumulating evidence suggests that noncoding RNAs (ncRNAs) have important regulatory functions. However, lacking of functional annotations for ncRNAs hampered us from carrying out the subsequent functional or predictive research. Here we dissected the expression profiles of 3,458 rat noncoding genes using rat bodymap RNA-sequencing data consisting of 11 solid organs over four developmental stages (juvenile, adolescent, adult and aged) from both sexes, and conducted a comprehensive analysis of differentially expressed noncoding genes (DEnGs) between various conditions...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27930853/association-between-small-intestinal-bacterial-overgrowth-and-deep-vein-thrombosis-in-patients-with-spinal-cord-injuries
#8
Xuan Cheng, Lu Zhang, Nan-Chang Xie, Hong-Liang Xu, Ya-Jun Lian
BACKGROUND: Gastrointestinal dysfunction and vein thrombosis are well-known acute complications after spinal cord injuries (SCI). OBJECTIVE: The aim of this study was to determine the frequency and risk factors for deep vein thrombosis (DVT) and small intestinal bacterial overgrowth (SIBO) in patients with SCI. METHODS: A total of 377 consecutive eligible patients with SCI tested for SIBO using glucose hydrogen (H2)/methane(CH4) breath test from January 2011 to December 2015 and who also had venous ultrasound study for suspected DVT were evaluated within 3 months after admission...
December 8, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27890460/prevalence-of-small-intestinal-bacterial-overgrowth-in-multiple-sclerosis-a-case-control-study-from-china
#9
Yongbo Zhang, Guoyi Liu, Yuanli Duan, Xinwen Han, Huihua Dong, Jia Geng
OBJECTIVE: It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS: The present study was a case-control type, it included 118 patients with definitive MS and 118 age-sex matched controls. Progression of disability was assessed using the Multiple Sclerosis Severity Score (MSSS)...
December 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27866737/enhanced-nitrogen-loss-from-rivers-through-coupled-nitrification-denitrification-caused-by-suspended-sediment
#10
Xinghui Xia, Ting Liu, Zhifeng Yang, Greg Michalski, Shaoda Liu, Zhimei Jia, Sibo Zhang
Present-day estimations of global nitrogen loss (N-loss) are underestimated. Commonly, N-loss from rivers is thought to be caused by denitrification only in bed-sediments. However, coupled nitrification-denitrification occurring in overlying water with suspended sediments (SPS) where oxic and anoxic/low oxygen zones may coexist is ignored for N-loss in rivers. Here the Yellow and Yangtze Rivers were taken as examples to investigate the effect of SPS, which exists in many rivers of the world, on N loss through coupled nitrification-denitrification with nitrogen stable ((15)N) isotopic tracer simulation experiments and in-situ investigation...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27788486/gata4-promotes-hepatoblastoma-cell-proliferation-by-altering-expression-of-mir125b-and-dkk3
#11
Yihua Pei, Qin Yao, Sibo Yuan, Bozhen Xie, Yan Liu, Chunsheng Ye, Huiqin Zhuo
GATA4 is a zinc finger DNA-binding protein that plays an important role in mammalian liver development. However, the effects of GATA4 in hepatoblastoma (HB), a common liver cancer in pediatric patients, remain largely unknown. In this study, we demonstrate that GATA4 promotes growth and survival in the Huh6 human hepatoblastoma cell line. GATA4 expression was high in Huh6 cells, and its knockdown decreased expression of Dickkopf-related protein 3 (DKK3), a gene that may contribute to premature or undifferentiated phenotypes in HB...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27733912/systematic-review-and-meta-analysis-small-intestinal-bacterial-overgrowth-in-chronic-pancreatitis
#12
Gabriele Capurso, Marianna Signoretti, Livia Archibugi, Serena Stigliano, Gianfranco Delle Fave
BACKGROUND: Evidence on small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP) is conflicting. AIM: The purpose of this study was to perform a systematic review and meta-analysis on the prevalence of SIBO in CP and to examine the relationship of SIBO with symptoms and nutritional status. METHODS: Case-control and cross-sectional studies investigating SIBO in CP patients were analysed. The prevalence of positive tests was pooled across studies, and the rate of positivity between CP cases and controls was calculated...
October 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27717036/lewis-acid-accelerated-aryl-ether-bond-cleavage-with-nickel-orders-of-magnitude-rate-enhancement-using-alme3
#13
Paul Kelley, Guy A Edouard, Sibo Lin, Theodor Agapie
Study of the kinetics of intramolecular aryl ether C-O bond cleavage by Ni was facilitated by access to a family of metal complexes supported by diphosphines with pendant aryl-methyl ethers. The nature of the aryl substituents was found to have little effect on the rate of cleavage. In contrast, soluble Lewis acidic additives accelerate the aryl ether cleavage dramatically. The effect of AlMe3 was studied in detail, and showed an increase in rate by several orders of magnitude. Low temperature NMR spectroscopy studies demonstrate quantitative coordination of ether to Al...
November 21, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27716759/-correlation-between-the-presence-and-intensity-of-symptoms-and-the-results-of-hydrogen-breath-tests-in-the-diagnosis-of-carbohydrate-intolerance
#14
María Teresa Sánchez-Ávila, Karla Lorena Chávez Caraza, Adrián Marcelo González Gil, Jaime Javier Cantú Pompa, Edgar Moreno Medrano, Luis Alonso Morales-Garza
BACKGROUND: Hydrogen breath tests (HBT) are used to confirm the diagnosis of carbohydrate intolerance or small intestinal bacterial overgrowth (SIBO). OBJECTIVE: Determine the existence of a correlation between the presence and intensity of symptoms experimented by the patient after the ingestion of a carbohydrate load and the test result. MATERIALS AND METHODS: This is an observational, retrospective and analytic study, in which all patients' files from year 2008 to 2014 containing a report of a HBT performed at Hospital San José TEC de Monterrey were revised...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27681080/clinical-experience-with-the-use-of-anti-cdtb-and-anti-vinculin-antibodies-in-patients-with-diarrhea-in-mexico
#15
M Schmulson, R Balbuena, C Corona de Law
INTRODUCTION: Circulating anti-CdtB/anti-vinculin antibodies have been validated as biomarkers to distinguish IBS-D from IBD, but there is no experience with them in Latin America. MATERIALS AND METHODS: The analysis was carried out on patients seen at a FGIDs/motility clinic over the last 7 months for diarrhea with abdominal pain and/or bloating who were tested for these antibodies. The patients were diagnosed according to the Rome III criteria or with organic disorders, and those presenting with IBS were further classified as post-infectious (PI) or non-PI-IBS...
October 2016: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/27650225/lubiprostone-accelerates-intestinal-transit-and-alleviates-small-intestinal-bacterial-overgrowth-in-patients-with-chronic-constipation
#16
Irene Sarosiek, Mohammad Bashashati, Alicia Alvarez, Mark Hall, Nagasri Shankar, Yvette Gomez, Richard W McCallum, Jerzy Sarosiek
BACKGROUND: Lubiprostone is an effective treatment for chronic constipation (CC). The mechanism of action of lubiprostone is through increasing fluid secretion and lubrication of the intestinal lumen. The effects of lubiprostone on gastrointestinal transit and small intestinal bacterial overgrowth (SIBO) have not been adequately explored. The current study was designed to investigate whether lubiprostone (1) alters gastrointestinal transit and (2) affects SIBO in patients with constipation...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27589873/prevalence-of-small-intestinal-bacterial-overgrowth-in-chinese-patients-with-parkinson-s-disease
#17
Xiao-Lu Niu, Li Liu, Zhi-Xiu Song, Qing Li, Zhi-Hua Wang, Jian-Long Zhang, He-Hua Li
Parkinson's disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth (SIBO). The aim of the study was to assess the prevalence of SIBO in Chinese patients with PD and the potential impact of SIBO on gastrointestinal symptoms and motor function. 182 consecutive Chinese patients with PD patients and 200 sex, age, and BMI-matched subjects without PD were included. All participants underwent the glucose breath test to assess SIBO...
December 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27586816/functional-13-c-urea-and-glucose-hydrogen-methane-breath-tests-reveal-significant-association-of-small-intestinal-bacterial-overgrowth-in-individuals-with-active-helicobacter-pylori-infection
#18
Dietmar Enko, Gernot Kriegshäuser
OBJECTIVES: Helicobacter pylori infection is considered to alter the bacterial flora in the upper gastrointestinal tract. This study aimed at investigating the presence of small intestinal bacterial overgrowth (SIBO) in patients with active H. pylori infection assessed by functional breath testing. DESIGN AND METHODS: A total of 109 outpatients, who were referred for the H. pylori(13)C-urea breath test ((13)C-UBT) by general practitioners and specialists, were also tested for the presence of SIBO by the glucose hydrogen (H2)/methane (CH4) breath test (HMBT)...
January 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/27582480/improvement-in-severe-lower-respiratory-symptoms-and-small-airway-function-in-world-trade-center-dust-exposed-community-members
#19
Caralee Caplan-Shaw, Angeliki Kazeros, Deepak Pradhan, Kenneth Berger, Roberta Goldring, Sibo Zhao, Mengling Liu, Yongzhao Shao, Maria Elena Fernandez-Beros, Michael Marmor, Nomi Levy-Carrick, Rebecca Rosen, Lucia Ferri, Joan Reibman
OBJECTIVE: Longitudinal assessment of lower respiratory symptoms (LRS) in community members with World Trade Center (WTC) exposures. METHODS: Adult members of a treatment program with complete standardized visits were evaluated (n = 798). Association of demographic characteristics, mental health symptoms and lung function with trajectory of LRS between initial and monitoring visit was evaluated. RESULTS: Severe LRS were present in 70% at initial and 63% at monitoring visit...
September 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/27576576/consequences-of-small-intestinal-bacterial-overgrowth-in-obese-patients-before-and-after-bariatric-surgery
#20
Jean-Marc Sabate, Muriel Coupaye, Séverine Ledoux, Benjamin Castel, Simon Msika, Benoit Coffin, Pauline Jouet
BACKGROUND AND AIMS: Small intestinal bacterial overgrowth (SIBO) has been described in obese patients. The aim of this study was to prospectively evaluate the prevalence and consequences of SIBO in obese patients before and after bariatric surgery. PATIENTS AND METHODS: From October 2001 to July 2009, in obese patients referred for bariatric surgery (BMI >40 kg/m(2) or >35 in association with comorbidities), a glucose hydrogen (H2) breath test (BT) was performed before and/or after either Roux-en-Y gastric bypass (RYGBP) or adjustable gastric banding (AGB) to assess the presence of SIBO...
August 30, 2016: Obesity Surgery
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