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https://www.readbyqxmd.com/read/29334532/cost-effectiveness-and-improved-parent-and-provider-satisfaction-with-outpatient-management-of-pediatric-oncology-patients-with-low-risk-fever-and-neutropenia
#1
Abhishek Bavle, Amanda Grimes, Sibo Zhao, Daniel Zinn, Andrea Jackson, Binita Patel, Timothy Porea, Ankhi Dutta, Heidi Russell, Andras Heczey
On the basis of significant evidence for safety, the international pediatric fever and neutropenia committee recommends the identification and management of patients with "low-risk fever and neutropenia" (LRFN), outpatient with oral antibiotics, instead of traditional inpatient management. The aim of our study was to compare the cost-per-patient with these 2 strategies, and to evaluate parent and provider satisfaction with the outpatient management of LRFN. Between March 2016 and February 2017, 17 LRFN patients (median absolute neutrophil count, 90/μL) were managed at a single institution, per new guidelines...
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29326369/successful-treatment-of-postural-orthostatic-tachycardia-and-mast-cell-activation-syndromes-using-naltrexone-immunoglobulin-and-antibiotic-treatment
#2
Leonard B Weinstock, Jill B Brook, Trisha L Myers, Brent Goodman
A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immunotherapy with low-dose naltrexone (LDN) and intravenous immunoglobulin (IVIg) and antibiotic therapy for small intestinal bacterial overgrowth (SIBO). A dramatic and sustained response was documented. The utility of IVIg in autoimmune neuromuscular diseases has been published, but clinical experience with POTS is relatively unknown and has not been reported in MCAS. As a short-acting mu-opioid antagonist, LDN paradoxically increases endorphins which then bind to regulatory T cells which regulate T-lymphocyte and B-lymphocyte production and this reduces cytokine and antibody production...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29315497/health-care-disparities-among-octogenarians-and-nonagenarians-with-stage-iii-lung-cancer
#3
Richard J Cassidy, Xinyan Zhang, Jeffrey M Switchenko, Pretesh R Patel, Joseph W Shelton, Sibo Tian, Ronica H Nanda, Conor E Steuer, Rathi N Pillai, Taofeek K Owonikoko, Suresh S Ramalingam, Felix G Fernandez, Seth D Force, Theresa W Gillespie, Walter J Curran, Kristin A Higgins
BACKGROUND: To the authors' knowledge, the practice patterns for patients aged more than 80 years with stage III non-small cell lung cancer (NSCLC) is not well known. The purpose of the current study was to investigate factors predictive of and the impact on overall survival (OS) after concurrent chemoradiation (CRT) among patients aged ≥80 years with American Joint Committee on Cancer stage III NSCLC in the National Cancer Data Base (NCDB). METHODS: In the NCDB, patients aged ≥80 years who were diagnosed with stage III NSCLC from 2004 to 2013 with complete treatment records were identified...
January 8, 2018: Cancer
https://www.readbyqxmd.com/read/29309957/the-age-specific-characteristics-of-medically-serious-suicide-attempters-aged-15-45-years-in-rural-china
#4
Yanzheng Liu, Jie Zhang, Long Sun, Sibo Zhao
This aim of this study was to identify unique characteristics of serious suicide attempters across different age groups. Face to face interviews were conducted with medically serious suicide attempters in rural hospitals in two provinces in China (n = 791). The sample included three age groups: 15-24, 25-34, and 35-45. While there were some consistent patterns that emerged across the age groups, there were also some significant age-related patterns that emerged. Serious suicide attempters aged 15-24 were more likely to be well educated, never married, hold Party membership, and impulsive, and to be least likely to perceive social support and be in a peasant occupation...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29228433/the-relationship-between-small-intestinal-bacterial-overgrowth-and-irritable-bowel-syndrome
#5
X-W Ding, Y-X Liu, X-C Fang, K Liu, Y-Y Wei, M-H Shan
OBJECTIVE: To explore the relationship between small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS). PATIENTS AND METHODS: Fifty IBS patients in the hospital from January 2015 to December 2015 were assigned to the treatment group, and 50 healthy persons were assigned to the control group. Lactulose hydrogen and methane breath test were performed to measure the percentage of SIBO and oro-cecal transit time (OCTT) in treatment group and control group...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29227645/structural-trends-in-monoboronyl-compounds-analysis-of-the-interaction-of-second-row-elements-with-bo
#6
Pilar Redondo, Victor M M Rayon, Carmen Barrientos, Antonio Largo
A theoretical study of the monoboronyl compounds of second-row elements, [XBO] (X=Na, Si, P, S, Cl), has been carried out. It is observed that the preference for the XBO arrangement is higher when moving to the right of the period. In the case of sodium monoboronyl three minima were characterized, all lying rather close in energy: linear NaBO, linear NaOB and a L-shape structure. Linear NaBO and the L-shape structure are nearly isoenergetic, whereas linear NaOB is located 2.11 kcal/mol above linear NaBO. The barrier for the conversion of the L-shape structure into linear NaBO is about 5...
December 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29223815/attenuation-of-bacterial-cytotoxicity-of-carbon-nanotubes-by-riverine-suspended-solids-in-water
#7
Baotong Zhu, Xinghui Xia, Sibo Zhang, Yuchen Tang
The impact of solid particles on ecotoxicity of nanomaterials in water environments is poorly understood. This study investigated the effect of natural riverine suspended solids (SPS) on the cytotoxicity of single-walled carbon nanotubes (SWCNTs) towards a bacterium, Ochrobactrum sp. in water. Compared with SWCNT suspension without SPS, the presence of SPS at different concentrations ranging from 20 to 400 mg L-1 markedly increased the survival rates of bacteria exposed to 50 mg L-1 SWCNTs and bacterial survival rates increased with SPS concentrations by a power law...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29220164/ambidextrous-chirality-transfer-capability-from-cellulose-tris-phenylcarbamate-to-non-helical-chain-like-luminophores-achiral-solvent-driven-helix-helix-transition-of-oligo-and-polyfluorenes-revealed-by-sign-inversion-of-circularly-polarized-luminescence-cpl
#8
Sibo Guo, Hiroki Kamite, Nozomu Suzuki, Laibing Wang, Asuka Ohkubo, Michiya Fujiki
We investigated whether helicity and/or chirality of cellulose tris(phenylcarbamate) (CTPC) can transfer to non-charged, non-helical oligo- and polyfluorenes (F3, F5, F7, PF6, and PF8, Chart 1) when CTPC was employed as a solution processable homochiral platform of a D-glucose-skeletal polymer. Noticeably, CTPC revealed the solvent-driven, ambidextrous intermolecular helicity/chirality transfer capability to these fluorenes. The chiroptical inversion characteristics of circularly polarized luminescence (CPL) and the corresponding CD spectra were realized by solely choosing a proper achiral solvents and/or achiral cosolvents...
December 8, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29215610/breath-testing-consensus-guidelines-for-sibo-res-ipsa-locquitor
#9
William Paterson, Michael Camilleri, Magnus Simren, Guy Boeckxstaens, Stephen J Vanner
No abstract text is available yet for this article.
December 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29188472/small-intestinal-bacterial-overgrowth-should-screening-be-included-in-the-pre-fecal-microbiota-transplantation-evaluation
#10
Jessica R Allegretti, Zain Kassam, Walter W Chan
BACKGROUND: Fecal microbiota transplantation (FMT) is safe and effective for recurrent Clostridium difficile infection (rCDI) and often involves terminal ileal (TI) stool infusion. Patients report gastrointestinal (GI) symptoms post-FMT despite rCDI resolution. Small intestinal bacterial overgrowth (SIBO) screening is not routinely performed pre-FMT. The effect of donor/recipient SIBO status on FMT outcomes and post-FMT GI symptoms is unclear. We aim to evaluate the value of pre-FMT SIBO screening on post-FMT outcomes and symptoms...
November 29, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29180555/the-diagnostic-value-of-the-patient-s-reason-for-encounter-for-diagnosing-cancer-in-primary-care
#11
Kees van Boven, Annemarie A Uijen, Nina van de Wiel, Sibo K Oskam, Henk J Schers, Willem J J Assendelft
PURPOSE: Family physicians (FPs) have to recognize alarm symptoms and estimate the probability of cancer to manage these symptoms correctly. Mostly, patients start the consultation with a spontaneous statement on why they visit the doctor. This is also called the reason for encounter (RFE). It precedes the interaction and interpretation by FPs and patients. The aim of this study is to investigate the predictive value of alarm symptoms as the RFE for diagnosing cancer in primary care. DESIGN AND SETTING: Retrospective cohort study in a Dutch practice-based research network (Family Medicine Network)...
November 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29152094/xenotransplantation-of-pediatric-low-grade-gliomas-confirms-the-enrichment-of-braf-v600e-mutation-and-preservation-of-cdkn2a-deletion-in-a-novel-orthotopic-xenograft-mouse-model-of-progressive-pleomorphic-xanthoastrocytoma
#12
Mari Kogiso, Lin Qi, Holly Lindsay, Yulun Huang, Xiumei Zhao, Zhigang Liu, Frank K Braun, Yuchen Du, Huiyuan Zhang, Goeun Bae, Sibo Zhao, Sarah G Injac, Mary Sobieski, David Brunell, Vidya Mehta, Diep Tran, Jeffrey Murray, Patricia A Baxter, Xiao-Jun Yuan, Jack M Su, Adekunle Adesina, Laszlo Perlaky, Murali Chintagumpala, D Williams Parsons, Ching C Lau, Clifford C Stephan, Xinyan Lu, Xiao-Nan Li
To identify cellular and molecular changes that driver pediatric low grade glioma (PLGG) progression, we analyzed putative cancer stem cells (CSCs) and evaluated key biological changes in a novel and progressive patient-derived orthotopic xenograft (PDOX) mouse model. Flow cytometric analysis of 22 PLGGs detected CD133(+) (<1.5%) and CD15(+) (20.7 ± 28.9%) cells, and direct intra-cranial implantation of 25 PLGGs led to the development of 1 PDOX model from a grade II pleomorphic xanthoastrocytoma (PXA). While CSC levels did not correlate with patient tumor progression, neurosphere formation and in vivo tumorigenicity, the PDOX model, IC-3635PXA, reproduced key histological features of the original tumor...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150304/are-the-estrogenic-hormonal-effects-of-environmental-toxins-affecting-small-intestinal-bacterial-and-microfilaria-overgrowth
#13
Edward Lichten
The important role of microfilaria (worms) in human and animal disease remains an area of key disagreement between the naturopathic and allopathic physicians. While microfilaria infections are rampart in undeveloped countries, they rarely rise to identification as a cause of disease in Western countries. New research studies in the diagnosis and treatment of SIBO (Small Intestinal Bacterial Overgrowth) and (IBD) Inflammatory Bowel Diseases of ulcerative colitis, Crohn's Disease and microcytic colitis may make both sides equally correct...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29118931/outcome-of-breath-tests-in-adult-patients-with-suspected-small-intestinal-bacterial-overgrowth
#14
Johanna Mattsson, Maria Teresa Minaya, Milka Monegro, Benjamin Lebwohl, Suzanne K Lewis, Peter Hr Green, Reidun Stenberg
Aim: The aim was to investigate breath test outcomes in patients with suspected SIBO and indicative symptoms of SIBO, diagnosed by breath testing. Background: Breath testing is used to detect small intestinal bacterial overgrowth (SIBO) by measuring hydrogen and methane produced by intestinal bacteria. Methods: This retrospective cross sectional study included 311 patients with gastrointestinal symptoms who underwent the breath test for evaluation of SIBO at Celiac Disease Center at Columbia University, New York, in 2014-2015...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29116762/formation-of-hierarchical-in2s3-cdin2s4-heterostructured-nanotubes-for-efficient-and-stable-visible-light-co2-reduction
#15
Sibo Wang, Bu Yuan Guan, Yan Lu, Xiong Wen David Lou
We demonstrate rational design and fabrication of hierarchical In2S3-CdIn2S4 heterostructured nanotubes as efficient and stable photocatalysts for visible light CO2 reduction. The novel self-templated strategy, including sequential anion- and cation-exchange reactions, integrates two distinct sulfide semiconductors into hierarchical tubular hybrids with homogeneous interfacial contacts and ultrathin two-dimensional (2D) nanosheet subunits. Accordingly, the hierarchical heterostructured nanotubes facilitate separation and migration of photoinduced charge carriers, enhance the adsorption and concentration of CO2 molecules, and offer rich active sites for surface redox reactions...
November 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29110161/association-between-small-intestinal-bacterial-overgrowth-by-glucose-breath-test-and-coronary-artery-disease
#16
Andre Fialho, Andrea Fialho, Gursimran Kochhar, Aldo L Schenone, Prashanti Thota, Arthur J McCullough, Bo Shen
BACKGROUND: A possible role of gut bacteria and their metabolic by-products in the development of coronary artery disease (CAD) is suspected. There is a lack of studies evaluating the association of small intestinal bacterial overgrowth (SIBO) with the development of CAD. AIM: To evaluate the frequency and risk factors for angiography-confirmed CAD in patients with or without SIBO. METHODS: A total of 1059 patients tested for SIBO using the glucose hydrogen/methane breath test from 2006 to 2014 were evaluated...
November 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29101772/liver-disease-symptoms-in-non-alcoholic-fatty-liver-disease-and-small-intestinal-bacterial-overgrowth
#17
Rahmatollah Rafiei, Mahboobeh Bemanian, Fereshteh Rafiei, Mahmood Bahrami, Lotfollah Fooladi, Giti Ebrahimi, Ahmadreza Hemmat, Zahra Torabi
INTRODUCTION: It seems that there is a relationship between small intestinal bacterial overgrowth (SIBO) and non-alcoholic fatty liver disease (NAFLD). The main objective of this study was to evaluate the prevalence of SIBO among NAFLD patients. METHODS: In this descriptive-analytical cross-sectional study, 98 eligible NAFLD patients were evaluated for SIBO using hydrogen breath test (HBT). They were divided into SIBO-positive and SIBO-negative groups. Demographic, clinical, and laboratory data were obtained...
October 26, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29093626/faecal-microbiota-transplantation-in-patients-with-clostridium-difficile-and-significant-comorbidities-as-well-as-in-patients-with-new-indications-a-case-series
#18
Perttu Lahtinen, Eero Mattila, Veli-Jukka Anttila, Jyrki Tillonen, Matti Teittinen, Pasi Nevalainen, Seppo Salminen, Reetta Satokari, Perttu Arkkila
Fecal microbiota transplantation (FMT) is effective in recurrent Clostridium difficile infection (rCDI). Knowledge of the safety and efficacy of FMT treatment in immune deficient patients is scarce. FMT has been suggested as a potential method for an increasing number of new indications besides rCDI. Among our FMT-treated rCDI patients, we reviewed those with major comorbidities: two human immunodeficiency virus patients, six haemodialysis patients, two kidney transplant patients, two liver transplant patients and a patient with chronic lymphatic leukaemia...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29049893/fecal-microbiota-analysis-of-children-with-small-intestinal-bacterial-overgrowth-among-residents-of-an-urban-slum-in-brazil
#19
Carolina Santos Mello, Mirian Silva do Carmo Rodrigues, Humberto Bezerra de Araújo Filho, Lígia Cristina Fonseca Lahoz Melli, Soraia Tahan, Antônio Carlos Campos Pignatari, Mauro Batista de Morais
OBJECTIVE: To analyze the fecal microbiota composition of children living in an urban slum in Brazil, with or without small intestinal bacterial overgrowth, and to investigate the occurrence of stunting and anemia. METHODS: A total of 100 children were studied, aged 5-11 years, from the municipality of Osasco, São Paulo. Small intestinal bacterial overgrowth was screened through hydrogen and methane breath test with lactulose. Weight and height were measured, and the height-for-age and body mass-for-age anthropometric indexes were calculated...
October 16, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29035975/breath-hydrogen-testing-in-east-and-southeast-asia
#20
Chu Kion Yao, Natural Hoi Sing Chu, Victoria Ping Yi Tan
Breath hydrogen tests are popular, noninvasive tests for the assessment of carbohydrate fermentation in patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). There is limited information regarding the utility of breath hydrogen and methane tests in IBS and FD patients in East and Southeast Asia. This review aims to summarize current literature about common indications of breath testing in this region, the genesis of functional gastrointestinal symptoms by provocative breath testing and provide suggestions for correct use...
October 13, 2017: Journal of Clinical Gastroenterology
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