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https://www.readbyqxmd.com/read/29761252/testing-and-treating-small-intestinal-bacterial-overgrowth-reduces-symptoms-in-patients-with-inflammatory-bowel-disease
#1
Shirley Cohen-Mekelburg, Zaid Tafesh, Elliot Coburn, Russell Weg, Neena Malik, Colleen Webb, Hoda Hammad, Ellen Scherl, Brian P Bosworth
BACKGROUND: Common mechanisms against small intestinal bacterial overgrowth (SIBO), including an intact ileocecal valve, gastric acid secretion, intestinal motility, and an intact immune system, are compromised in inflammatory bowel disease (IBD), and therefore, a relatively high incidence of SIBO has been reported in this population. AIMS: We aimed to determine whether an improvement in IBD clinical activity scores is seen after testing and treating SIBO. METHODS: A retrospective cohort study of 147 patients with inflammatory bowel disease who were referred for SIBO breath testing from 1/2012 to 5/2016 was performed...
May 14, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29761234/prevalence-and-predictors-of-small-intestinal-bacterial-overgrowth-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#2
REVIEW
Binrui Chen, John Jae-Woo Kim, Yawen Zhang, Lijun Du, Ning Dai
BACKGROUND: The reported prevalence of small intestinal bacterial overgrowth (SIBO) among individuals with irritable bowel syndrome (IBS) is highly variable. The aim of the study is to estimate the prevalence and identify predictors of SIBO in IBS. METHODS: PubMed, Cochrane Library, and EMBASE through July 2017 were searched to identify studies evaluating the prevalence of SIBO in IBS. The pooled prevalence of SIBO among individuals with IBS and the pooled odds ratio (OR) of SIBO among those with IBS compared with healthy controls were calculated...
May 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29708180/stereotactic-body-radiation-therapy-vs-surgery-in-early-stage-non-small-cell-lung-cancer-lessons-learned-current-recommendations-future-directions
#3
EDITORIAL
Sibo Tian, Kristin A Higgins, Walter J Curran, Richard J Cassidy
No abstract text is available yet for this article.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29691369/does-colectomy-predispose-to-small-intestinal-bacterial-sibo-and-fungal-overgrowth-sifo
#4
Satish S C Rao, George Tan, Hamza Abdulla, Siegfried Yu, Sebastian Larion, Pornchai Leelasinjaroen
OBJECTIVES: After subtotal colectomy, 40% of patients report chronic gastrointestinal symptoms and poor quality of life. Its etiology is unknown. We determined whether small intestinal bacterial overgrowth (SIBO) or small intestinal fungal overgrowth (SIFO) cause gastrointestinal symptoms after colectomy. METHODS: Consecutive patients with unexplained abdominal pain, gas, bloating and diarrhea (>1 year), and without colectomy (controls), and with colectomy were evaluated with symptom questionnaires, glucose breath test (GBT) and/or duodenal aspiration/culture...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29687525/does-a-glucose-based-hydrogen-and-methane-breath-test-detect-bacterial-overgrowth-in-the-jejunum
#5
O H Sundin, A Mendoza-Ladd, E Morales, B M Fagan, M Zeng, D Diaz-Arévalo, J Ordoñez, R W McCallum
BACKGROUND: Direct diagnosis of small intestinal bacterial overgrowth (SIBO) requires the collection and culture of fluid from the jejunal lumen, with a finding of over 105 viable bacteria per mL. More often, SIBO is diagnosed indirectly, using a non-invasive test of the exhaled hydrogen and methane generated by microbial fermentation when ingested glucose reaches the jejunum. Our objective was to determine how well this breath test detects chronic overgrowth of jejunal bacteria that is unrelated to gastrointestinal surgery...
April 23, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29678362/bowel-symptoms-in-patients-that-receive-proton-pump-inhibitors-results-of-a-multicenter-survey-in-mexico
#6
M J Schmulson, A C Frati-Munari
INTRODUCTION: Proton pump inhibitors (PPIs) have been associated with small intestinal bacterial overgrowth (SIBO), which increases with prolonged PPI use, and SIBO has been associated with irritable bowel syndrome (IBS). OBJECTIVE: The aim of the present study was to study the prevalence of bowel symptoms in patients treated with PPIs in Mexico. METHODS: Gastroenterologists in 36 cities surveyed patients treated with PPIs, utilizing an ad hoc questionnaire to determine the presence of bowel symptoms and IBS...
April 17, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29649743/recent-advances-in-trimethoxyphenyl-tmp-based-tubulin-inhibitors-targeting-the-colchicine-binding-site
#7
REVIEW
Ling Li, Sibo Jiang, Xiaoxun Li, Yao Liu, Jing Su, Jianjun Chen
Microtubules (composed of α- and β-tubulin heterodimers) play a pivotal role in mitosis and cell division, and are regarded as an excellent target for chemotherapeutic agents to treat cancer. There are four unique binding sites in tubulin to which taxanes, vinca alkaloids, laulimalide and colchicine bind respectively. While several tubulin inhibitors that bind to the taxane or vinca alkaloid binding sites have been approved by FDA, currently there are no FDA approved tubulin inhibitors targeting the colchicine binding site...
April 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29596112/vagal-dysfunction-and-small-intestinal-bacterial-overgrowth-novel-pathways-to-chronic-inflammation-in-hiv
#8
Jessica Robinson-Papp, Alexandra Nmashie-Osei, Elizabeth Pedowitz, Emma K T Benn, Mary C George, Sandeep Sharma, Jacinta Murray, Josef Machac, Sherif Heiba, Saurabh Mehandru, Seunghee Kim-Schulze, Allison Navis, Isabel Elicer, Susan Morgello
OBJECTIVE: Chronic inflammation in HIV-infected individuals drives disease progression and the development of comorbidities, despite viral suppression with combined antiretroviral therapy. Here, we sought evidence that vagal dysfunction, which occurs commonly as part of HIV-associated autonomic neuropathy, could exacerbate inflammation through gastrointestinal dysmotility, small intestinal bacterial overgrowth (SIBO), and alterations in patterns of soluble immune mediators. DESIGN: This is a cross-sectional observational study...
March 28, 2018: AIDS
https://www.readbyqxmd.com/read/29590754/construction-of-znin2s4-in2o3-hierarchical-tubular-heterostructures-for-efficient-co2-photoreduction
#9
Sibo Wang, Bu Yuan Guan, Xiong Wen David Lou
We demonstrate the rational design and construction of sandwich-like ZnIn2S4-In2O3 hierarchical tubu-lar heterostructures as photocatalysts for efficient visible-light CO2 reduction. The unique design effectively inte-grates In2O3 and ZnIn2S4 semiconductors into hierarchical one-dimensional (1D) open architectures with ZnIn2S4-In2O3 double-heterojunction shells and ultrathin two-dimensional (2D) ZnIn2S4 nanosheet subu-nits. This design remarkably accelerates the separation and transfer of photogenerated charges, offers large sur-face area for CO2 adsorption, and exposes abundant active sites for surface catalysis...
March 29, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29575224/oral-psoriasis-and-sibo-is-there-a-link
#10
LETTER
F Drago, G Ciccarese, V Cordara, M Paudice, A Herzum, A Parodi
No abstract text is available yet for this article.
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29541503/discrimination-of-lymphoma-using-laser-induced-breakdown-spectroscopy-conducted-on-whole-blood-samples
#11
Xue Chen, Xiaohui Li, Sibo Yang, Xin Yu, Aichun Liu
Lymphoma is a significant cancer that affects the human lymphatic and hematopoietic systems. In this work, discrimination of lymphoma using laser-induced breakdown spectroscopy (LIBS) conducted on whole blood samples is presented. The whole blood samples collected from lymphoma patients and healthy controls are deposited onto standard quantitative filter papers and ablated with a 1064 nm Q-switched Nd:YAG laser. 16 atomic and ionic emission lines of calcium (Ca), iron (Fe), magnesium (Mg), potassium (K) and sodium (Na) are selected to discriminate the cancer disease...
March 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29535443/the-north-american-consensus-on-breath-testing-the-controversial-diagnostic-role-of-lactulose-in-sibo
#12
Paolo Usai-Satta, Cristiana Giannetti, Francesco Oppia, Francesco Cabras
No abstract text is available yet for this article.
March 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29508268/effect-of-a-preparation-of-four-probiotics-on-symptoms-of-patients-with-irritable-bowel-syndrome-association-with-intestinal-bacterial-overgrowth
#13
Konstantinos Leventogiannis, Paraskevas Gkolfakis, Georgios Spithakis, Aikaterini Tsatali, Aikaterini Pistiki, Athanasios Sioulas, Evangelos J Giamarellos-Bourboulis, Konstantinos Triantafyllou
The effect of probiotics on small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome (IBS) has never been studied so far. In this prospective trial, five patients with IBS and SIBO and 21 patients with IBS without SIBO were administered an oral capsule containing Saccharomyces boulardii, Bifidobacterium lactis, Lactobacillus acidophilus, and Lactobacillus plantarum (Lactolevure® ) every 12 h for 30 days. SIBO was defined by quantitative culture of the third part of the duodenum; IBS was defined by the Rome III criteria...
March 5, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29502987/the-prevalence-of-small-intestinal-bacterial-overgrowth-in-non-surgical-patients-with-chronic-pancreatitis-and-pancreatic-exocrine-insufficiency-pei
#14
Hazel M Ní Chonchubhair, Yasir Bashir, Mark Dobson, Barbara M Ryan, Sinead N Duggan, Kevin C Conlon
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is a condition characterised by symptoms similar to pancreatic exocrine insufficiency (PEI) in chronic pancreatitis patients. SIBO is thought to complicate chronic pancreatitis in up to 92% of cases; however, studies are heterogeneous and protocols non-standardised. SIBO may be determined by measuring lung air-expiration of either hydrogen or methane which are by-products of small bowel bacterial fermentation of intraluminal substrates such as carbohydrates...
February 24, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29464583/intestinal-involvement-in-systemic-sclerosis-a-clinical-review
#15
REVIEW
Lazaros I Sakkas, Theodora Simopoulou, Dimitrios Daoussis, Stamatis-Nick Liossis, Spyros Potamianos
Systemic sclerosis (SSc) is a chronic systemic disease characterized by microvasculopathy, autoantibodies, and extensive fibrosis. Intestinal involvement is frequent in SSc and represents a significant cause of morbidity. The pathogenesis of intestinal involvement includes vascular damage, nerve dysfunction, smooth muscle atrophy, and fibrosis, causing hypomotility, which leads to small intestinal bacterial overgrowth (SIBO), malabsorption, malnutrition, diarrhea, pseudo-obstruction, constipation, pneumatosis intestinalis, and fecal incontinence...
April 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29463553/concurrent-inhibition-of-neurosphere-and-monolayer-cells-of-pediatric-glioblastoma-by-aurora-a-inhibitor-mln8237-predicted-survival-extension-in-pdox-models
#16
Mari Kogiso, Lin Qi, Frank K Braun, Sarah G Injac, Linna Zhang, Yuchen Du, Huiyuan Zhang, Frank Y Lin, Sibo Zhao, Holly Lindsay, Jack M Su, Patricia A Baxter, Adekunle M Adesina, Debra Liao, Mark G Qian, Stacey Berg, Jodi A Muscal, Xiao-Nan Li
Purpose: Pediatric glioblastoma multiforme (pGBM) is a highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of MLN8237 (alisertib), an orally available selective inhibitor of Aurora A kinase (AURKA), and to evaluate which in vitro model system (monolayer or neurosphere) can predict therapeutic efficacy in vivo Experimental Design: AURKA mRNA expressions were screened with qRT-PCR. In vitro antitumor effects were examined in three matching pairs of monolayer and neurosphere lines established from patient-derived orthotopic xenograft (PDOX) models of the untreated (IC-4687GBM), recurrent (IC-3752GBM), and terminal (IC-R0315GBM) tumors, and in vivo therapeutic efficacy through log rank analysis of survival times in two models (IC-4687GBM and IC-R0315GBM) following MLN8237 treatment (30 mg/kg/day, orally, 12 days)...
May 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29461641/mutational-studies-of-the-aux-iaa-proteins-in-physcomitrella-reveal-novel-insights-into-their-function
#17
Sibo Tao, Mark Estelle
The plant hormone auxin regulates many aspects of plant growth and development. Auxin signaling involves hormone perception by the TRANSPORT INHIBITOR RESPONSE/AUXIN F-BOX (TIR1/AFB)-Aux/IAA co-receptor system, and the subsequent degradation of the Aux/IAA transcriptional repressors by the ubiquitin proteasome pathway. This leads to the activation of downstream gene expression and diverse physiological responses. Here, we investigate how the structural elements in the Aux/IAAs determine their function in Auxin perception and transcriptional repression...
June 2018: New Phytologist
https://www.readbyqxmd.com/read/29451382/carbon-nanotube-formic-acid-sensors-using-a-nickel-bis-ortho-diiminosemiquinonate-selector
#18
Sibo Lin, Timothy M Swager
Formic acid is corrosive, and a sensitive and selective sensor could be useful in industrial, medical, and environmental settings. We present a chemiresistor for detection of formic acid composed of single-walled carbon nanotubes (CNTs) and nickel bis( ortho-diiminosemiquinonate) (1), a planar metal complex that can act as a ditopic hydrogen-bonding selector. Formic acid is detected in concentrations as low as 83 ppb. The resistance of the material decreases on exposure to formic acid, but slightly increases on exposure to acetic acid...
March 23, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29433301/prevalence-of-fructose-malabsorption-in-patients-with-irritable-bowel-syndrome-after-excluding-small-intestinal-bacterial-overgrowth
#19
Kee Wook Jung, Myeognsook Seo, Young Hwan Cho, Young-Ok Park, So-Yoon Yoon, Jungbok Lee, Dong-Hoon Yang, In Ja Yoon, So Young Seo, Hyo Jeong Lee, Sang Hyoung Park, Kyung Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Hwoon-Yong Jung, Suk-Kyun Yang, Jin-Ho Kim, Seung-Jae Myung
Background/Aims: Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath test (HBT). Methods: Patients diagnosed with IBS and asymptomatic control individuals were enrolled prospectively...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29413012/small-intestinal-bacterial-overgrowth-nutritional-implications-diagnosis-and-management
#20
REVIEW
Abimbola Adike, John K DiBaise
Small intestinal bacterial overgrowth (SIBO), characterized by the presence of excessive bacteria in the small intestine, is typically described as a malabsorptive syndrome occurring in the context of gut stasis syndromes. SIBO is now considered to be a disorder associated with diverse clinical conditions without classic risk factors for SIBO and a cause of several nonspecific gastrointestinal and nongastrointestinal symptoms. Because there is currently no gold standard for diagnosing SIBO, its prevalence and role in the pathogenesis of other diseases remain uncertain; as does optimal treatment of patients with relapsing symptoms...
March 2018: Gastroenterology Clinics of North America
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