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https://www.readbyqxmd.com/read/27890460/prevalence-of-small-intestinal-bacterial-overgrowth-in-multiple-sclerosis-a-case-control-study-from-china
#1
Yongbo Zhang, Guoyi Liu, Yuanli Duan, Xinwen Han, Huihua Dong, Jia Geng
OBJECTIVE: It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS: The present study was a case-control type, it included 118 patients with definitive MS and 118 age-sex matched controls. Progression of disability was assessed using the Multiple Sclerosis Severity Score (MSSS)...
November 16, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27866737/enhanced-nitrogen-loss-from-rivers-through-coupled-nitrification-denitrification-caused-by-suspended-sediment
#2
Xinghui Xia, Ting Liu, Zhifeng Yang, Greg Michalski, Shaoda Liu, Zhimei Jia, Sibo Zhang
Present-day estimations of global nitrogen loss (N-loss) are underestimated. Commonly, N-loss from rivers is thought to be caused by denitrification only in bed-sediments. However, coupled nitrification-denitrification occurring in overlying water with suspended sediments (SPS) where oxic and anoxic/low oxygen zones may coexist is ignored for N-loss in rivers. Here the Yellow and Yangtze Rivers were taken as examples to investigate the effect of SPS, which exists in many rivers of the world, on N loss through coupled nitrification-denitrification with nitrogen stable ((15)N) isotopic tracer simulation experiments and in-situ investigation...
November 17, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27788486/gata4-promotes-hepatoblastoma-cell-proliferation-by-altering-expression-of-mir125b-and-dkk3
#3
Yihua Pei, Qin Yao, Sibo Yuan, Bozhen Xie, Yan Liu, Chunsheng Ye, Huiqin Zhuo
GATA4 is a zinc finger DNA-binding protein that plays an important role in mammalian liver development. However, the effects of GATA4 in hepatoblastoma (HB), a common liver cancer in pediatric patients, remain largely unknown. In this study, we demonstrate that GATA4 promotes growth and survival in the Huh6 human hepatoblastoma cell line. GATA4 expression was high in Huh6 cells, and its knockdown decreased expression of Dickkopf-related protein 3 (DKK3), a gene that may contribute to premature or undifferentiated phenotypes in HB...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27733912/systematic-review-and-meta-analysis-small-intestinal-bacterial-overgrowth-in-chronic-pancreatitis
#4
Gabriele Capurso, Marianna Signoretti, Livia Archibugi, Serena Stigliano, Gianfranco Delle Fave
BACKGROUND: Evidence on small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP) is conflicting. AIM: The purpose of this study was to perform a systematic review and meta-analysis on the prevalence of SIBO in CP and to examine the relationship of SIBO with symptoms and nutritional status. METHODS: Case-control and cross-sectional studies investigating SIBO in CP patients were analysed. The prevalence of positive tests was pooled across studies, and the rate of positivity between CP cases and controls was calculated...
October 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27717036/lewis-acid-accelerated-aryl-ether-bond-cleavage-with-nickel-orders-of-magnitude-rate-enhancement-using-alme3
#5
Paul Kelley, Guy A Edouard, Sibo Lin, Theodor Agapie
Study of the kinetics of intramolecular aryl ether C-O bond cleavage by Ni was facilitated by access to a family of metal complexes supported by diphosphines with pendant aryl-methyl ethers. The nature of the aryl substituents was found to have little effect on the rate of cleavage. In contrast, soluble Lewis acidic additives accelerate the aryl ether cleavage dramatically. The effect of AlMe3 was studied in detail, and showed an increase in rate by several orders of magnitude. Low temperature NMR spectroscopy studies demonstrate quantitative coordination of ether to Al...
November 21, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27716759/-correlation-between-the-presence-and-intensity-of-symptoms-and-the-results-of-hydrogen-breath-tests-in-the-diagnosis-of-carbohydrate-intolerance
#6
María Teresa Sánchez-Ávila, Karla Lorena Chávez Caraza, Adrián Marcelo González Gil, Jaime Javier Cantú Pompa, Edgar Moreno Medrano, Luis Alonso Morales-Garza
BACKGROUND: Hydrogen breath tests (HBT) are used to confirm the diagnosis of carbohydrate intolerance or small intestinal bacterial overgrowth (SIBO). OBJECTIVE: Determine the existence of a correlation between the presence and intensity of symptoms experimented by the patient after the ingestion of a carbohydrate load and the test result. MATERIALS AND METHODS: This is an observational, retrospective and analytic study, in which all patients' files from year 2008 to 2014 containing a report of a HBT performed at Hospital San José TEC de Monterrey were revised...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27681080/clinical-experience-with-the-use-of-anti-cdtb-and-anti-vinculin-antibodies-in-patients-with-diarrhea-in-mexico
#7
M Schmulson, R Balbuena, C Corona de Law
INTRODUCTION: Circulating anti-CdtB/anti-vinculin antibodies have been validated as biomarkers to distinguish IBS-D from IBD, but there is no experience with them in Latin America. MATERIALS AND METHODS: The analysis was carried out on patients seen at a FGIDs/motility clinic over the last 7 months for diarrhea with abdominal pain and/or bloating who were tested for these antibodies. The patients were diagnosed according to the Rome III criteria or with organic disorders, and those presenting with IBS were further classified as post-infectious (PI) or non-PI-IBS...
October 2016: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/27650225/lubiprostone-accelerates-intestinal-transit-and-alleviates-small-intestinal-bacterial-overgrowth-in-patients-with-chronic-constipation
#8
Irene Sarosiek, Mohammad Bashashati, Alicia Alvarez, Mark Hall, Nagasri Shankar, Yvette Gomez, Richard W McCallum, Jerzy Sarosiek
BACKGROUND: Lubiprostone is an effective treatment for chronic constipation (CC). The mechanism of action of lubiprostone is through increasing fluid secretion and lubrication of the intestinal lumen. The effects of lubiprostone on gastrointestinal transit and small intestinal bacterial overgrowth (SIBO) have not been adequately explored. The current study was designed to investigate whether lubiprostone (1) alters gastrointestinal transit and (2) affects SIBO in patients with constipation...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27589873/prevalence-of-small-intestinal-bacterial-overgrowth-in-chinese-patients-with-parkinson-s-disease
#9
Xiao-Lu Niu, Li Liu, Zhi-Xiu Song, Qing Li, Zhi-Hua Wang, Jian-Long Zhang, He-Hua Li
Parkinson's disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth (SIBO). The aim of the study was to assess the prevalence of SIBO in Chinese patients with PD and the potential impact of SIBO on gastrointestinal symptoms and motor function. 182 consecutive Chinese patients with PD patients and 200 sex, age, and BMI-matched subjects without PD were included. All participants underwent the glucose breath test to assess SIBO...
December 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27586816/functional-13-c-urea-and-glucose-hydrogen-methane-breath-tests-reveal-significant-association-of-small-intestinal-bacterial-overgrowth-in-individuals-with-active-helicobacter-pylori-infection
#10
Dietmar Enko, Gernot Kriegshäuser
OBJECTIVES: Helicobacter pylori infection is considered to alter the bacterial flora in the upper gastrointestinal tract. This study aimed at investigating the presence of small intestinal bacterial overgrowth (SIBO) in patients with active H. pylori infection assessed by functional breath testing. DESIGN AND METHODS: A total of 109 outpatients, who were referred for the H. pylori(13)C-urea breath test ((13)C-UBT) by general practitioners and specialists, were also tested for the presence of SIBO by the glucose hydrogen (H2)/methane (CH4) breath test (HMBT)...
August 30, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27582480/improvement-in-severe-lower-respiratory-symptoms-and-small-airway-function-in-world-trade-center-dust-exposed-community-members
#11
Caralee Caplan-Shaw, Angeliki Kazeros, Deepak Pradhan, Kenneth Berger, Roberta Goldring, Sibo Zhao, Mengling Liu, Yongzhao Shao, Maria Elena Fernandez-Beros, Michael Marmor, Nomi Levy-Carrick, Rebecca Rosen, Lucia Ferri, Joan Reibman
OBJECTIVE: Longitudinal assessment of lower respiratory symptoms (LRS) in community members with World Trade Center (WTC) exposures. METHODS: Adult members of a treatment program with complete standardized visits were evaluated (n = 798). Association of demographic characteristics, mental health symptoms and lung function with trajectory of LRS between initial and monitoring visit was evaluated. RESULTS: Severe LRS were present in 70% at initial and 63% at monitoring visit...
September 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/27576576/consequences-of-small-intestinal-bacterial-overgrowth-in-obese-patients-before-and-after-bariatric-surgery
#12
Jean-Marc Sabate, Muriel Coupaye, Séverine Ledoux, Benjamin Castel, Simon Msika, Benoit Coffin, Pauline Jouet
BACKGROUND AND AIMS: Small intestinal bacterial overgrowth (SIBO) has been described in obese patients. The aim of this study was to prospectively evaluate the prevalence and consequences of SIBO in obese patients before and after bariatric surgery. PATIENTS AND METHODS: From October 2001 to July 2009, in obese patients referred for bariatric surgery (BMI >40 kg/m(2) or >35 in association with comorbidities), a glucose hydrogen (H2) breath test (BT) was performed before and/or after either Roux-en-Y gastric bypass (RYGBP) or adjustable gastric banding (AGB) to assess the presence of SIBO...
August 30, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27569528/exendin-4-decreases-ghrelin-levels-through-mtor-signaling
#13
Xiaosi Hong, Heng Zhang, Hongbin Liang, Danjie Li, Jiana Huang, Zhi Li, Sibo Jiang, Weizhen Zhang, Geyang Xu
Exendin-4 (EX-4), a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, regulates feeding behavior through its ability to inhibit gastric emptying. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate appetite. Here, we report that EX-4 suppresses ghrelin production through the mTORC1-dependent mechanism. Central administration of EX-4 reduces gastric, hypothalamic and plasma ghrelin in both C57BL/6J mice and diet induced obese mice. These changes were associated with a significant increase in mTORC1 activity...
December 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27535109/small-intestinal-bacterial-overgrowth-in-adult-patients-with-type-1-diabetes-its-prevalence-and-relationship-with-metabolic-control-and-the-presence-of-chronic-complications-of-the-disease
#14
Anna Adamska, Michalina Nowak, Stanisław Piłaciński, Aleksandra Araszkiewicz, Monika Litwinowicz, Małgorzata Tomaszewska, Bogna Wierusz-Wysocka, Marian Grzymisławski, Dorota Zozulińska-Ziółkiewicz
INTRODUCTION Gastrointestinal symptoms may occur in 50% to 70% of patients with diabetes. OBJECTIVES The aim of this study was to evaluate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with diabetes, as well as the relationship between SIBO and metabolic control of diabetes and the presence of chronic complications of the disease. PATIENTS AND METHODS The study group included 148 patients with type 1 diabetes, treated in the years 2013-2015. The control group consisted of 41 healthy volunteers...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27501017/rosacea-and-gastrointestinal-disorders-a-population-based-cohort-study
#15
A Egeberg, L B Weinstock, E P Thyssen, G H Gislason, J P Thyssen
BACKGROUND: Rosacea is a common inflammatory facial skin condition. Recent genetic and epidemiologic studies have suggested pathogenic links between rosacea and gastrointestinal disorders, but data are limited. OBJECTIVES: The objective was to investigate the association between rosacea and celiac disease (CeD), Crohn's disease (CD), ulcerative colitis (UC), Helicobactor pylori (HP) infection, small intestinal bacterial overgrowth (SIBO), and irritable bowel syndrome (IBS), respectively...
August 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27446865/prevalence-of-small-intestinal-bacterial-overgrowth-among-chronic-pancreatitis-patients-a-case-control-study
#16
Amelie Therrien, Simon Bouchard, Sacha Sidani, Mickael Bouin
Background. Patients with chronic pancreatitis (CP) exhibit numerous risk factors for the development of small intestinal bacterial overgrowth (SIBO). Objective. To determine the prevalence of SIBO in patients with CP. Methods. Prospective, single-centre case-control study conducted between January and September 2013. Inclusion criteria were age 18 to 75 years and clinical and radiological diagnosis of CP. Exclusion criteria included history of gastric, pancreatic, or intestinal surgery or significant clinical gastroparesis...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27446263/neuronal-uptake-of-serum-albumin-is-associated-with-neuron-damage-during-the-development-of-epilepsy
#17
Zanhua Liu, Jinjie Liu, Suping Wang, Sibo Liu, Yongbo Zhao
It is well established that brain blood barrier dysfunction following the onset of seizures may lead to serum albumin extravasation into the brain. However, the effect of albumin extravasation on the development of epilepsy is yet to be fully elucidated. Previous studies have predominantly focused on the effect of albumin absorption by astrocytes; however, the present study investigated the effects of neuronal uptake of albumin in vitro and in kainic acid-induced Sprague-Dawley rat models of temporal lobe epilepsy...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27417083/construction-of-in-vivo-fluorescent-imaging-of-echinococcus-granulosus-in-a-mouse-model
#18
Sibo Wang, Tao Yang, Xuyong Zhang, Jie Xia, Jun Guo, Xiaoyi Wang, Jixue Hou, Hongwei Zhang, Xueling Chen, Xiangwei Wu
Human hydatid disease (cystic echinococcosis, CE) is a chronic parasitic infection caused by the larval stage of the cestode Echinococcus granulosus. As the disease mainly affects the liver, approximately 70% of all identified CE cases are detected in this organ. Optical molecular imaging (OMI), a noninvasive imaging technique, has never been used in vivo with the specific molecular markers of CE. Thus, we aimed to construct an in vivo fluorescent imaging mouse model of CE to locate and quantify the presence of the parasites within the liver noninvasively...
June 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27402085/small-intestinal-bacterial-overgrowth-is-associated-with-irritable-bowel-syndrome-and-is-independent-of-proton-pump-inhibitor-usage
#19
Evangelos J Giamarellos-Bourboulis, Emmanouel Pyleris, Charalambos Barbatzas, Aikaterini Pistiki, Mark Pimentel
BACKGROUND: Current knowledge suggests that small intestinal overgrowth participates in the pathogenesis of irritable bowel syndrome. It is questionable if this association is modulated by intake of proton pump inhibitors (PPIs). METHODS: In a prospective study, quantitative cultures of duodenal aspirates were performed for aerobic species in 897 consecutive patients undergoing upper GI tract endoscopy. SIBO was defined as equal to or more than 10(3) cfu/ml. The effect of PPI intake on the relationship between SIBO and IBS was the primary endpoint...
2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27379166/small-intestinal-bacterial-overgrowth-in-patients-with-irritable-bowel-syndrome-clinical-characteristics-psychological-factors-and-peripheral-cytokines
#20
Hua Chu, Mark Fox, Xia Zheng, Yanyong Deng, Yanqin Long, Zhihui Huang, Lijun Du, Fei Xu, Ning Dai
Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathogenesis of irritable bowel syndrome (IBS). Psychosocial factors and low-grade colonic mucosal immune activation have been suggested to play important roles in the pathophysiology of IBS. In total, 94 patients with IBS and 13 healthy volunteers underwent a 10 g lactulose hydrogen breath test (HBT) with concurrent (99m)Tc scintigraphy. All participants also completed a face-to-face questionnaire survey, including the Hospital Anxiety and Depression Scale, Life Event Stress (LES), and general information...
2016: Gastroenterology Research and Practice
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