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https://www.readbyqxmd.com/read/28822053/colorectal-cancer-patient-s-self-efficacy-for-managing-illness-related-problems-in-the-first-2%C3%A2-years-after-diagnosis-results-from-the-colorectal-well-being-crew-study
#1
Chloe Grimmett, Joanne Haviland, Jane Winter, Lynn Calman, Amy Din, Alison Richardson, Peter W F Smith, Claire Foster
PURPOSE: There is a growing emphasis on self-management of cancer aftercare. Little is known about patient's self-efficacy (confidence) to manage illness-related problems and how this changes over time. This paper describes the patterns of self-efficacy for managing illness-related problems amongst colorectal cancer patients in the 2 years following diagnosis. METHODS: In this prospective cohort study, questionnaires were administered at baseline (pre-surgery), 3, 9, 15 and 24 months to 872 colorectal cancer patients...
August 19, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28820946/proteogenomic-investigation-of-strain-variation-in-clinical-mycobacterium-tuberculosis-isolates
#2
Tiaan Heunis, Anzaan Dippenaar, Robin M Warren, Paul D van Helden, Ruben G van der Merwe, Nicolaas C Gey van Pittius, Arnab Pain, Samantha L Sampson, David L Tabb
Mycobacterium tuberculosis consists of a large number of different strains that display unique virulence characteristics. Whole-genome sequencing has revealed substantial genetic diversity among clinical M. tuberculosis isolates, and elucidating the phenotypic variation encoded by this genetic diversity will be of utmost importance to fully understand M. tuberculosis biology and pathogenicity. In this study we integrated whole-genome sequencing and mass spectrometry (GeLC-MS/MS) to reveal strain-specific characteristics in the proteomes of two clinical M...
August 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28809075/allosteric-modulation-of-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-desformylflustrabromine-potentiates-antiallodynic-response-of-nicotine-in-a-mouse-model-of-neuropathic-pain
#3
D Bagdas, D Ergun, A Jackson, W Toma, M K Schulte, M I Damaj
BACKGROUND: Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels. The α4β2 subtype of nAChRs plays an important role in the mediation of pain and several nicotine-evoked responses. Agonists and partial agonists of α4β2 nAChRs show efficacy in animal pain models. In addition, the antinociceptive properties of nicotine, a non-selective nAChR agonist with a high affinity for α4β2 nAChRs, is well-known. There is a growing body of evidence pointing to allosteric modulation of nAChRs as an alternative treatment strategy in experimental pain...
August 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28805590/nonmotor-fluctuations-in-parkinson-s-disease
#4
Christiana Franke, Alexander Storch
The advanced stage of Parkinson's disease (PD) is characterized by motor complications such as motor fluctuations and dyskinesias induced by long-term levodopa treatment. Recent clinical research provides growing evidence that various nonmotor symptoms such as neuropsychiatric, autonomic, and sensory symptoms (particularly pain) also show fluctuations in patients with motor fluctuations (called nonmotor fluctuations or NMF). However, NMF have not yet been adequately considered in routine care of advanced PD patients and only few therapeutic studies are available...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28800186/ameliorative-response-to-detoxification-psychotherapy-and-medical-management-in-patients-maintained-on-opioids-for-pain
#5
Molly Belkin, Howard Stephen Reinheimer, Jordan Levy, Brian Johnson
BACKGROUND AND OBJECTIVES: The prevalence of opioid-induced hyperalgesia (OIH) among patients maintained on opioids for chronic non-malignant pain has not been estimated. As a contribution toward establishing its prevalence, we report a case series of opioid maintained patients whose pain tolerance was measured by the cold pressor test at baseline. METHODS: A case series of 117 patients who had undergone detoxification was reviewed retrospectively. Most patients (n = 108) and selected non-addicted support persons who accompanied them (controls; n = 37) had cold pressor time (CPT) assessments at baseline...
August 11, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28799492/potentials-and-limits-of-physiotherapy-in-osteoarthritis
#6
Katrin Richter, Ulf Müller-Ladner, Gabnel Dischereit, Uwe Lange
In view of the already existing and the expected growing costs due to the pathological osteoarthritic joint alterations and the related consequences, preventive and conservative strategies which can avoid or delay osteoarthritic joint alterations are welcomed from a socio-economical perspective. Here, it should be mentioned that corresponding primary prevention measures should take place early by already educating children about a healthy diet and motivating them to regular physical exercise. In overt or symptomatic osteoarthritis a good joint function and reduction of disease-related pain as well as a delay in the progression of osteoarthritis should be the primary goals of non-surgical therapeutic approaches...
August 10, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28793865/perceived-consequences-of-ageing-with-late-effects-of-polio-and-strategies-for-managing-daily-life-a-qualitative-study
#7
Catharina Sjödahl Hammarlund, Jan Lexell, Christina Brogårdh
BACKGROUND: New or increased impairments may develop several decades after an acute poliomyelitis infection. These new symptoms, commonly referred to as late effects of polio (LEoP), are characterised by muscular weakness and fatigue, generalised fatigue, pain at rest or during activities and cold intolerance. Growing older with LEoP may lead to increased activity limitations and participation restrictions, but there is limited knowledge of how these persons perceive the practical and psychological consequences of ageing with LEoP and what strategies they use in daily life...
August 9, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28791443/outcomes-of-shoulder-arthroplasty-in-haematopoietic-stem-cell-transplant-patients
#8
Joseph M Statz, Brian P Chalmers, Cameron K Ledford, Joaquin Sanchez-Sotelo, John W Sperling, Mark E Morrey
BACKGROUND: With the growing population of patients undergoing haematopoietic stem cell transplants (HSCTs), the demand for shoulder arthroplasty (SA) in this population can be expected to increase. No studies in the literature have examined the outcomes of SA in HSCT patients. PATIENTS AND METHODS: A retrospective review of 11 SAs in 10 patients with previous HSCT was performed. We characterized the clinical outcomes, survivorship, and peri-operative complication rates in patients who underwent SA after receiving a HSCT...
August 9, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28783442/a-literature-review-on-current-and-proposed-technologies-of-noninvasive-blood-pressure-measurement
#9
Ramtanu Mukherjee, Sanchita Ghosh, Bharat Gupta, Tapas Chakravarty
BACKGROUND: Noninvasive continuous blood pressure (BP) measurement has become an evolving topic in the field of remote healthcare. The classical noninvasive BP measurement techniques provide spontaneous values of systolic and diastolic BP. On the other hand, intrusive type BP measurement techniques provide continuous values of systolic and diastolic BP. However, these techniques are very painful, cannot be used for long-term monitoring, and are obtainable only in an intensive care unit environment...
August 7, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28782703/the-contribution-of-the-international-pain-policy-fellowship-in-improving-opioid-availability-in-georgia
#10
Pati Dzotsenidze, Martha A Maurer, Dimitri Kordzaia, Ioseb Abesadze, Mary M Skemp Brown, Aaron M Gilson, James F Cleary
In the Republic of Georgia, the incidence and prevalence of cancer is increasing, signifying a growing need for palliative care and pain relief, including with controlled opioid medicines. As a signatory to the Single Convention, the Georgian government has a responsibility to ensure the adequate availability of controlled medicines for medical purposes, however the consumption of morphine is very low, suggesting a high occurrence of unrelieved pain. In Georgia, palliative care development began in the 2000s including the adoption of a policy document in 2005, the creation of the National Palliative Care Coordinator in 2006 and important changes in Georgian legislation in 2007 and 2008, which served to lay a foundation for improving opioid availability...
August 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28782695/analgesics-and-sport-performance-beyond-the-pain-modulating-effects
#11
REVIEW
Darias Holgado, James Hopker, Daniel Sanabria, Mikel Zabala
Analgesics are widely used in sport to treat pain and inflammation associated with injury. However, there is growing evidence that some athletes might be taking these substances in an attempt to enhance performance. While the pharmacological action of analgesics and their use in treating pain with and without anti-inflammatory effect is well established, their effect on sport performance is debated. The aim of this review was to evaluate the evidence of whether analgesics are capable of enhancing exercise performance, and if so, to what extent...
August 3, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28782082/utility-of-imaging-in-risk-stratification-of-chest-pain-in-women
#12
REVIEW
Emily S Lau, Amy Sarma
Recent decades have seen a growing recognition that the understanding of sex differences in cardiovascular disease (CVD) is vital to optimal diagnosis and management, particularly of women (Mosca et al. Circulation 124:2145-54, 2011). There is simultaneously an increasing appreciation of the multifactorial nature of ischemic heart disease (IHD) in many patients, in whom disease may extend beyond the epicardial coronaries. While obstructive coronary artery disease (CAD) remains underdiagnosed in women and still represents a major burden of disease, women also present with nonobstructive CAD more commonly than men (Patel et al...
September 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28780713/health-related-quality-of-life-in-spanish-informal-caregivers-gender-differences-and-support-received
#13
María Del Río Lozano, María Del Mar García-Calvente, Jesús Calle-Romero, Mónica Machón-Sobrado, Isabel Larrañaga-Padilla
PURPOSE: We analyzed gender differences in health-related quality of life (HRQoL) and associated factors between informal male and female caregivers in Spain. It is important because of growing rates of dependent people and dwindling public resources. METHODS: We conducted a cross-sectional study of 610 informal caregivers (265 male and 345 female) using an ad hoc structured questionnaire. We performed a descriptive analysis and used multivariate logistic regression to analyze the risk of poor HRQoL, measured with the EQ-5D-5L, according to caregiver sex, sociodemographic characteristics of caregivers and dependents, caregiving circumstances, and support received...
August 5, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28771952/prevalence-and-determinants-of-frailty-and-associated-comorbidities-among-older-gurkha-welfare-pensioners-in-nepal
#14
Sirjana Devkota, Bruce Anderson, Roy L Soiza, Phyo K Myint
AIM: Population aging is increasing in low-income countries. Despite this, there is distinct lack of knowledge about the prevalence of comorbidities and determinants of frailty among older people in these countries. METHODS: We examined data from "Health and Social Care Needs Assessment Survey of the Gurkha Welfare Pensioners" carried out in 2014. Participants were aged ≥60 years from the Gorakha, Lamjung and Tanahu districts of Nepal. Face-to-face interviews were carried out using validated questionnaires...
August 2, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28768437/clinical-descriptors-for-the-recognition-of-central-sensitization-pain-in-patients-with-knee-osteoarthritis
#15
Enrique Lluch, Jo Nijs, Carol A Courtney, Trudy Rebbeck, Vikki Wylde, Isabel Baert, Timothy H Wideman, Nick Howells, Søren T Skou
BACKGROUND: Despite growing awareness of the contribution of central pain mechanisms to knee osteoarthritis pain in a subgroup of patients, routine evaluation of central sensitization is yet to be incorporated into clinical practice. AIM: The objective of this perspective is to design a set of clinical descriptors for the recognition of central sensitization in patients with knee osteoarthritis that can be implemented in clinical practice. METHODS: A narrative review of original research papers was conducted by nine clinicians and researchers from seven different countries to reach agreement on clinically relevant descriptors...
August 2, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28761545/primary-pleomorphic-xanthoastrocytoma-of-the-spinal-cord-a-case-report-and-review-of-literature
#16
Mayur Sharma, Vernon Velho, Rachana Binayake, Hrushikesh Kharosekar
Primary pleomorphic xanthoastrocytoma (PXA) of the spinal cord is a rare slow growing tumor. To our knowledge, only five such cases have been reported in the literature till date. We report the clinical, radiological, and histopathological features of a spinal PXA in a 23-year-old female previously operated 5 years back for a spinal tumor, presented with weakness in lower limbs, sphincter incontinence and low back pain. Magnetic resonance imaging scan with contrast reveals an intramedullary lesion in the spinal cord from D8-D10 level...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28761371/dissatisfaction-with-own-body-makes-patients-with-eating-disorders-more-sensitive-to-pain
#17
Anna Yamamotova, Josef Bulant, Vaclav Bocek, Hana Papezova
Body image represents a multidimensional concept including body image evaluation and perception of body appearance. Disturbances of body image perception are considered to be one of the central aspects of anorexia nervosa and bulimia nervosa. There is growing evidence that body image distortion can be associated with changes in pain perception. The aim of our study was to examine the associations between body image perception, body dissatisfaction, and nociception in women with eating disorders and age-matched healthy control women...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28761270/medicinal-plants-and-bone-healing
#18
REVIEW
Vibha Singh
Fracture is defined as complete or incomplete separation in the continuity of bone Fracture healing is a complex physiological process that involves the coordinated participation of hematopoietic and immune cells within bone marrow. It conjunction with vascular and skeletal cell precursors it also includes mesenchymal stem cells which are recruited from the circulation and the surrounding tissues. It is estimated that 80% of the population in developing countries still rely on the traditional herbal medicines...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28759423/point-of-care-ultrasound-as-an-adjunct-in-the-diagnosis-of-neonatal-and-pediatric-superficial-soft-tissue-infection-a-report-of-two-cases
#19
Dalibor Kurepa, Colleen Galiczewski, Alison Civale, Vitaliya Boyar
Considerable technological advances, good safety profile, and ease of use have converged to support the use of ultrasound (US) as an important adjunct in the evaluation of superficial soft tissue infections (SSTI) in general and the differential diagnosis of cellulitis and abscess in particular. However, its use in neonatal populations has not been described. Pediatric studies report clinical examination is not always a reliable method of distinguishing cellulitis from abscess. Two (2) case reports are presented to supplement the growing body of published data that describe US imaging of SSTIs...
July 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28759254/emerging-utility-of-virtual-reality-as-a-multidisciplinary-tool-in-clinical-medicine
#20
Ali Pourmand, Steven Davis, Danny Lee, Scott Barber, Neal Sikka
OBJECTIVE: Among the more recent products borne of the evolution of digital technology, virtual reality (VR) is gaining a foothold in clinical medicine as an adjunct to traditional therapies. Early studies suggest a growing role for VR applications in pain management, clinical skills training, cognitive assessment and cognitive therapy, and physical rehabilitation. MATERIALS AND METHODS: To complete a review of the literature, we searched PubMed and MEDLINE databases with the following search terms: "virtual reality," "procedural medicine," "oncology," "physical therapy," and "burn...
July 31, 2017: Games for Health
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