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https://www.readbyqxmd.com/read/29145629/the-reactome-pathway-knowledgebase
#1
Antonio Fabregat, Steven Jupe, Lisa Matthews, Konstantinos Sidiropoulos, Marc Gillespie, Phani Garapati, Robin Haw, Bijay Jassal, Florian Korninger, Bruce May, Marija Milacic, Corina Duenas Roca, Karen Rothfels, Cristoffer Sevilla, Veronica Shamovsky, Solomon Shorser, Thawfeek Varusai, Guilherme Viteri, Joel Weiser, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D'Eustachio
The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations-an extended version of a classic metabolic map, in a single consistent data model. Reactome functions both as an archive of biological processes and as a tool for discovering unexpected functional relationships in data such as gene expression profiles or somatic mutation catalogues from tumor cells...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29134238/a-comparison-of-anterograde-versus-retrograde-approaches-for-neonatal-balloon-aortic-valvuloplasty
#2
Namrita Mozumdar, Edmund Burke, Melissa Schweizer, Matthew J Gillespie, Yoav Dori, Hari K Narayan, Jonathan J Rome, Andrew C Glatz
In neonates requiring balloon aortic valvuloplasty, both anterograde and retrograde approaches are feasible. A recent comparison of these two approaches is lacking. A retrospective cohort study of neonates at a single center undergoing BAV from 9/00 to 7/14 was performed. Records were reviewed including pre- and post-intervention echocardiograms and catheterization data. Comparisons of acute efficacy and procedural safety were made based on type of approach utilized. Forty-two neonates underwent BAV. Eleven cases utilized exclusively an anterograde approach, while 31 included a retrograde approach (including 4 with both approaches used)...
November 13, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29132246/phage-derived-protein-mediated-targeted-chemotherapy-of-pancreatic-cancer
#3
Tao Wang, Radhika Narayanaswamy, Huilan Ren, James W Gillespie, Valery A Petrenko, Vladimir P Torchilin
Pancreatic cancer has been a life-threatening illness associated with high incidence and mortality rates. Paclitaxel that causes mitotic arrest in cancer cells disrupting microtubule function is used for pancreatic cancer treatment[1]. Nausea, anorexia and abdominal pain are some of the typical dose-limiting toxicity associated gastrointestinal side effects of the drug[2]. Here we present the use of polymeric mixed micelles to enable a targeted delivery of Paclitaxel and to provide additional advantages such as enhanced drug solubility, bioavailability and minimal dose-limiting toxicity...
November 13, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29127947/the-first-external-quality-assessment-of-isolation-and-identification-of-influenza-viruses-in-cell-culture-in-the-asia-pacific-region-2016
#4
Patrick C Reading, Vivian K Leung, Iwona Buettner, Leah Gillespie, Yi-Mo Deng, Robert Shaw, Natalie Spirason, Angela Todd, Aparna Singh Shah, Frank Konings, Ian G Barr
BACKGROUND: The isolation and propagation of influenza viruses from clinical specimens are essential tools for comprehensive virologic surveillance. Influenza viruses must be amplified in cell culture for detailed antigenic analysis and for phenotypic assays assessing susceptibility to antiviral drugs or for other assays. OBJECTIVES: To conduct an external quality assessment (EQA) of proficiency for isolation and identification of influenza viruses using cell culture techniques among National Influenza Centres (NICs) in the World Health Organisation (WHO) South East Asia and Western Pacific Regions...
November 2, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29127340/hair-cortisol-in-twins-heritability-and-genetic-overlap-with-psychological-variables-and-stress-system-genes
#5
Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H Witt, Tina M Binz, John McGrath, Ian B Hickie, Narelle K Hansell, Margaret J Wright, Nathan A Gillespie, Andreas J Forstner, Thomas G Schulze, Stefan Wüst, Markus M Nöthen, Markus R Baumgartner, Brian R Walker, Andrew A Crawford, Lucía Colodro-Conde, Sarah E Medland, Nicholas G Martin, Marcella Rietschel
Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29123600/activities-performed-by-pharmacists-integrated-in-family-health-teams-results-from-a-web-based-survey
#6
Ulrika Gillespie, Lisa Dolovich, Simone Dahrouge
Objectives: Family health teams (FHTs), an interprofessional primary care practice model, were established in Ontario in 2005. As of October 2014, 191 FHT organizations were in operation, and 111 (58%) included one or several pharmacists. The objective of this study was to document the focus of pharmacist activities in FHTs. Approach: We invited all 155 known FHT pharmacists to a web-based survey. The survey was constructed using information obtained from previously done semi-structured telephone interviews with pharmacists working in FHTs...
November 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29117534/building-predictive-models-of-genetic-circuits-using-the-principle-of-maximum-caliber
#7
Taylor Firman, Gábor Balázsi, Kingshuk Ghosh
Learning the underlying details of a gene network is a major challenge in cellular and synthetic biology. We address this challenge by building a chemical kinetic model that utilizes information encoded in the stochastic protein expression trajectories typically measured in experiments. The applicability of the proposed method is demonstrated in an auto-activating genetic circuit, a common motif in natural and synthetic gene networks. Our approach is based on the principle of maximum caliber (MaxCal)-a dynamical analog of the principle of maximum entropy-and builds a minimal model using only three constraints: 1) protein synthesis, 2) protein degradation, and 3) positive feedback...
November 7, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29114002/sdf-1%C3%AE-stromal-cell-derived-factor-1%C3%AE-induces-cardiac-fibroblasts-renal-microvascular-smooth-muscle-cells-and-glomerular-mesangial-cells-to-proliferate-cause-hypertrophy-and-produce-collagen
#8
Edwin K Jackson, Yumeng Zhang, Delbert D Gillespie, Xiao Zhu, Dongmei Cheng, Travis C Jackson
BACKGROUND: Activated cardiac fibroblasts (CFs), preglomerular vascular smooth muscle cells (PGVSMCs), and glomerular mesangial cells (GMCs) proliferate, cause hypertrophy, and produce collagen; in this way, activated CFs contribute to cardiac fibrosis, and activated PGVSMCs and GMCs promote renal fibrosis. In heart and kidney diseases, SDF-1α (stromal cell-derived factor 1α; endogenous CXCR4 [C-X-C motif chemokine receptor 4] receptor agonist) levels are often elevated; therefore, it is important to know whether and how the SDF-1α/CXCR4 axis activates CFs, PGVSMCs, or GMCs...
November 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29113634/pharmacy-diabetes-management-of-a-veteran-population-in-a-long-term-care-setting-a-program-evaluation
#9
Forest Hansen, Hilary Teeples, Jordan Csati, Suzanne M Gillespie
BACKGROUND: The benefits of an outpatient pharmacy diabetes clinic has been established, with improved patient outcomes and reduced total costs of care. We describe the benefits of an inpatient clinical pharmacy diabetes service within a Department of Veterans Affairs long-term care facility. METHODS: Patients were referred to the pharmacy diabetes monitoring program between February 2016 and August 2016. During this time, clinical pharmacy specialists managed all pharmacotherapy relating to diabetes care as well as all fingerstick monitoring frequencies and laboratory monitoring to achieve a prespecified, patient-specific A1C goal...
November 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29109735/clostridium-difficile-in-inflammatory-bowel-disease-a-retrospective-study
#10
William Gillespie, Neil Marya, Julien Fahed, Gregory Leslie, Krunal Patel, David R Cave
Aim: To investigate the epidemiology and risk factors of Clostridium difficile infections (CDI) in patients with inflammatory bowel disease (IBD). Methods: This is a retrospective study of patients diagnosed with IBD. 1006 charts were screened and 654 patients met the inclusion criteria. Patients were divided into 2 cohorts based on the presence of prior diagnosis of CDI. Statistical analysis with Pearson's chi-squared and two-sample t-test was performed. Results: The incidence of CDI among IBD patients was 6...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29101177/a-novel-mitochondrial-dna-repair-enzyme-attenuates-maladaptive-remodeling-and-preserves-cardiac-function-in-heart-failure
#11
Jessica M Bradley, Zhen Li, Chelsea L Organ, David J Polhemus, Hiroyuki Otsuka, Shashi Bhushan, Olena M Gorodnya, Mykhaylo Ruchko, Mark N Gillespie, Glenn L Wilson, David J Lefer
BACKGROUND: Oxidative stress results in mitochondrial DNA (mtDNA) damage and contributes to myocardial cell death. mtDNA repair enzymes are crucial for mtDNA repair and cell survival. We investigated a novel, mitochondrial-targeted fusion protein (Exscien1-III) containing endonuclease III in myocardial ischemia/reperfusion (MI/Rep) injury and transverse aortic constriction (TAC) induced heart failure. METHODS AND RESULTS: Male C57/BL6J mice (10-12 wks) were subjected to 45 min...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29100565/nursing-code-of-ethics-provisions-and-interpretative-statements-for-emergency-nurses
#12
Diane Gurney, Gordon L Gillespie, Margaret Peggy McMahon, Monica Escalante Kolbuk
No abstract text is available yet for this article.
November 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29098350/reintervention-burden-and-vessel-growth-after-surgical-reimplantation-of-a-pulmonary-artery-during-childhood
#13
Stephan J Wu, Tacy Downing, Christopher Mascio, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Children requiring reimplantation of a branch pulmonary artery (PA) are at risk for postoperative stenosis and impaired growth of the reimplanted PA. Outcomes and risk factors for reintervention and impaired growth are incompletely described. We reviewed data on patients who underwent reimplantation of a branch PA between 1/1/99 and 5/1/15 at a single center. The primary outcome was reintervention to treat postoperative stenosis. The secondary outcome was "catch-up" growth (faster diameter growth of the affected PA compared with the unaffected PA from the preoperative to follow-up measurements...
November 2, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29095520/the-grand-challenge-of-great-ape-health-and-conservation-in-the-anthropocene
#14
Dominic A Travis, Elizabeth V Lonsorf, Thomas R Gillespie
"Ecosystem Health recognizes the inherent interdependence of the health of humans, animals and ecosystems and explores the perspectives, theories and methodologies emerging at the interface between ecological and health sciences." This broad focus requires new approaches and methods for solving problems of greater complexity at larger scales than ever before. Nowhere is this point more salient than the case of disease emergence and control at the human-non human primate interface in shrinking tropical forests under great anthropogenic pressure...
November 2, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/29095179/barriers-to-research-recruitment-of-women-experiencing-a-pregnancy-loss-in-the-emergency-department
#15
Brittany E Punches, Kimberly D Johnson, Shauna P Acquavita, Dianne M Felblinger, Gordon L Gillespie
Women often come to the emergency department (ED) with signs and symptoms suggesting an early pregnancy loss; yet, little is known about their experience and how it relates to future outcomes. To improve patient outcomes and experiences of women seeking care for a pregnancy loss, research is required. However, recruitment of participants experiencing an event such as a pregnancy loss is challenging. The purpose of this article is to discuss the application of an electronic medical record (EMR)-based participant screening tool recruiting women seeking care for a pregnancy loss in the ED...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29094368/adult-normative-data-for-phonatory-aerodynamics-in-connected-speech
#16
Ali Lewandowski, Amanda Gillespie, Samantha Kridgen, Kwonho Jeong, Lan Yu, Jackie Gartner-Schmidt
OBJECTIVES/HYPOTHESIS: To establish normative values for phonatory aerodynamic measurements in connected speech across adult ages and gender. STUDY DESIGN: Prospective data collection across group design. METHODS: One hundred fifty adults aged >18 years without voice complaints were stratified into three equal-age groups (group 1 [ages 18-39 years]; group 2 [ages 40-59 years], and group 3 [ages 60 + years]) and two equal-gender groups (male and female) resulting in 25 participants in each category...
November 2, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29094229/regular-marijuana-use-is-associated-with-poor-viral-suppression-in-hiv-infected-adolescents-and-young-adults
#17
Amelia B Thompson, Scott E Gillespie, Jasper Hood, LaTeshia Thomas-Seaton, Sophia A Hussen, Andres F Camacho-Gonzalez
There is a paucity of data regarding the impact of drug use on HIV suppression and care retention among adolescents and young adults (AYAs). We recruited a clinic-based sample of HIV infected AYAs to assess the prevalence of self-reported drug use. Clinical data, including retention and viral suppression, were abstracted from the electronic medical record. Logistic regression was used to evaluate marijuana and illicit drug use associations and to identify other risk factors. Of 200 participants (mean age 21, 2...
November 1, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29092028/patient-reported-health-status-and-all-cause-mortality-in-patients-with-coronary-heart-disease
#18
Adam J N Raymakers, Paddy Gillespie, Edel Murphy, Margaret E Cupples, Susan M Smith, Andrew W Murphy, Matthew D Griffin, Yael Benyamini, Molly Byrne
Purpose: Patients with coronary heart disease (CHD) experience reduced quality of life which may be associated with mortality in the longer term. This study explores whether patient-rated physical and mental health status was associated with mortality at 6-year follow-up among patients with CHD attending primary care in Ireland and Northern Ireland. Methods: This study is a secondary data analysis of patients with CHD recruited to a cluster randomized controlled trial from 2004 to 2010...
October 28, 2017: Family Practice
https://www.readbyqxmd.com/read/29091200/patterns-of-dispensed-non-medical-prescriber-prescriptions-for-antibiotics-in-primary-care-across-england-a-retrospective-analysis
#19
Molly Courtenay, David Gillespie, Rosemary Lim
Objectives: To describe the patterns of dispensed non-medical prescriber (NMP) prescriptions for antibiotics in primary care across England between 2011 and 2015. Methods: A retrospective analysis of dispensed antibiotic prescriptions, written by NMPs and medical prescribers between 2011 and 2015 in primary care in England, obtained from the National Health Service Business Services Authority. Results: Between 2011 and 2015, the number of NMPs (mainly nurses but also pharmacists and small numbers of allied health professionals) in England, who have independent prescribing capability, has risen by over one-third to nearly 30000...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29083871/phase-transition-of-h2-in-subnanometer-pores-observed-at-75-k
#20
Raina J Olsen, Andrew K Gillespie, Cristian I Contescu, Jonathan W Taylor, Peter Pfeifer, James R Morris
Here we report a phase transition in H2 adsorbed in a locally graphitic Saran carbon with subnanometer pores 0.5-0.65 nm in width, in which two layers of hydrogen can just barely squeeze, provided they pack tightly. The phase transition is observed at 75 K, temperatures far higher than other systems in which an adsorbent is known to increase phase transition temperatures: for instance, H2 melts at 14 K in the bulk, but at 20 K on graphite because the solid H2 is stabilized by the surface structure. Here we observe a transition at 75 K and 77-200 bar: from a low-temperature, low-density phase to a high-temperature, higher density phase...
November 7, 2017: ACS Nano
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