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https://www.readbyqxmd.com/read/28638528/meeting-the-primary-care-needs-of-transgender-patients-through-simulation
#1
Richard E Greene, Kathleen Hanley, Tiffany E Cook, Colleen Gillespie, Sondra Zabar
No abstract text is available yet for this article.
June 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28637309/anterior-cervical-pseudarthrosis-treated-with-bilateral-posterior-cervical-cages
#2
William Smith, Mark Gillespy, Jason Huffman, Veasna Vong, Bruce M McCormack
BACKGROUND: Pseudarthrosis after anterior cervical discectomy and fusion (ACDF) causes persistent pain and related disability. Posterior revision surgery results in higher healing rates, but is more extensive compared to anterior surgery. OBJECTIVE: To evaluate minimally disruptive, tissue sparing posterior fusion via bilateral placement of posterior cages between the facet joints as an alternative treatment option. METHODS: A retrospective, multicenter, medical chart review was performed and included 25 patients with symptomatic pseudarthrosis after ACDF treated with posterior cervical cages, and in select cases, anterior revision...
June 14, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28634586/the-referral-system-between-primary-and-secondary-health-care-in-saudi-arabia-for-patients-with-type-2-diabetes-a-systematic-review
#3
REVIEW
Mohammed Senitan, Ali Hassan Alhaiti, James Gillespie, Badar Faiz Alotaibi, George Binh Lenon
BACKGROUND: In Saudi Arabia, the mortality of diabetes is currently reported at 6%. A well-administered referral system is crucial in aiding the management of this disease. METHOD: A single reviewer employed a systematic approach to searching the literature databases with regard to the question: what are the attributes of referral systems in Saudi Arabia for patients with type 2 diabetes (T2D)? The results were analysed in order to provide recommendations to improve the Saudi health system...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28630888/gillespy-a-python-package-for-stochastic-model-building-and-simulation
#4
John H Abel, Brian Drawert, Andreas Hellander, Linda R Petzold
GillesPy is an open-source Python package for model construction and simulation of stochastic biochemical systems. GillesPy consists of a Python framework for model building and an interface to the StochKit2 suite of efficient simulation algorithms based on the Gillespie stochastic simulation algorithms (SSA). To enable intuitive model construction and seamless integration into the scientific Python stack, we present an easy to understand, action-oriented programming interface. Here, we describe the components of this package and provide a detailed example relevant to the computational biology community...
September 2016: IEEE Life Sciences Letters
https://www.readbyqxmd.com/read/28628071/reflective-responses-following-a-role-play-simulation-of-nurse-bullying
#5
Deborah L Ulrich, Gordon Lee Gillespie, Maura C Boesch, Kyle M Bateman, Paula L Grubb
A qualitative exploratory design was used for this study to evaluate role-play simulation as an active learning strategy. The context for the role-play was bullying in nursing practice. Following a simulation, 333 students from five college campuses of three universities completed a reflection worksheet. Qualitative thematic findings were personal responses, nonverbal communications exhibited, actions taken by participants, and the perceived impact of bullying during the simulation. Role-play simulation was a highly effective pedagogy, eliciting learning at both the cognitive and affective domains...
July 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28618965/time-dependent-effects-of-prognostic-biomarkers-of-systemic-inflammation-in-patients-with-metastatic-renal-cell-carcinoma
#6
Wayne B Harris, Chao Zhang, Yuan Liu, Dale K Robertson, Mikhail Y Akbashev, Brian M Lingerfelt, Omer Kucuk, Bradley C Carthon, Theresa W Gillespie, Adeboye O Osunkoya, Viraj A Master
The goal of this study was to examine time-dependent effects of prognostic biomarkers of systemic inflammation in patients with metastatic renal cell carcinoma. Retrospective chart reviews were conducted at the Winship Cancer Institute of Emory University and the Atlanta Veterans Administration Medical Center with authorization from the Emory University Institutional Review Board and the Veterans Administration Research and Development Committee. Inclusion criteria included age ⩾18 years, treatment with targeted therapy for clear cell or non-clear cell metastatic renal cell carcinoma and concomitant assessment of C-reactive protein and albumin levels on ⩾3 occasions that were ⩾10 days apart...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28617165/transplant-professionals-perceptions-of-long-term-care-residents-candidacy-for-kidney-transplantation
#7
Megan Urbanski, Teri Browne, Mythili Ghanta, Serban Constantinescu, Avrum Gillespie, Heather Hammer, Heather Traino
CONTEXT: Given the aging end-stage renal disease (ESRD) population, kidney transplant (KTx) centers may experience an increase in referrals of patients living in long-term care (LTC) settings (eg, skilled nursing facilities, assisted living facilities, group homes, and boarding homes). OBJECTIVE: To identify best practices among KTx professionals when considering individuals in LTC settings for transplantation. DESIGN AND SETTING: A cross-sectional survey administered online to US transplant professionals via e-mail LISTSERVs and other professional networks...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28609654/intertumoral-heterogeneity-within-medulloblastoma-subgroups
#8
Florence M G Cavalli, Marc Remke, Ladislav Rampasek, John Peacock, David J H Shih, Betty Luu, Livia Garzia, Jonathon Torchia, Carolina Nor, A Sorana Morrissy, Sameer Agnihotri, Yuan Yao Thompson, Claudia M Kuzan-Fischer, Hamza Farooq, Keren Isaev, Craig Daniels, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee, Wieslawa A Grajkowska, Marta Perek-Polnik, Alexandre Vasiljevic, Cecile Faure-Conter, Anne Jouvet, Caterina Giannini, Amulya A Nageswara Rao, Kay Ka Wai Li, Ho-Keung Ng, Charles G Eberhart, Ian F Pollack, Ronald L Hamilton, G Yancey Gillespie, James M Olson, Sarah Leary, William A Weiss, Boleslaw Lach, Lola B Chambless, Reid C Thompson, Michael K Cooper, Rajeev Vibhakar, Peter Hauser, Marie-Lise C van Veelen, Johan M Kros, Pim J French, Young Shin Ra, Toshihiro Kumabe, Enrique López-Aguilar, Karel Zitterbart, Jaroslav Sterba, Gaetano Finocchiaro, Maura Massimino, Erwin G Van Meir, Satoru Osuka, Tomoko Shofuda, Almos Klekner, Massimo Zollo, Jeffrey R Leonard, Joshua B Rubin, Nada Jabado, Steffen Albrecht, Jaume Mora, Timothy E Van Meter, Shin Jung, Andrew S Moore, Andrew R Hallahan, Jennifer A Chan, Daniela P C Tirapelli, Carlos G Carlotti, Maryam Fouladi, José Pimentel, Claudia C Faria, Ali G Saad, Luca Massimi, Linda M Liau, Helen Wheeler, Hideo Nakamura, Samer K Elbabaa, Mario Perezpeña-Diazconti, Fernando Chico Ponce de León, Shenandoah Robinson, Michal Zapotocky, Alvaro Lassaletta, Annie Huang, Cynthia E Hawkins, Uri Tabori, Eric Bouffet, Ute Bartels, Peter B Dirks, James T Rutka, Gary D Bader, Jüri Reimand, Anna Goldenberg, Vijay Ramaswamy, Michael D Taylor
While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28606850/the-impact-of-%C3%AE-lipoic-acid-on-cell-viability-and-expression-of-nephrin-and-znf580-in-normal-human-podocytes
#9
Ulrike Leppert, Allan Gillespie, Miriam Orphal, Karen Böhme, Claudia Plum, Kaj Nagorsen, Janine Berkholz, Reinhold Kreutz, Andreas Eisenreich
Human podocytes (hPC) are essential for maintaining normal kidney function and dysfunction or loss of hPC play a pivotal role in the manifestation and progression of chronic kidney diseases including diabetic nephropathy. Previously, α-Lipoic acid (α-LA), a licensed drug for treatment of diabetic neuropathy, was shown to exhibit protective effects on diabetic nephropathy in vivo. However, the effect of α-LA on hPC under non-diabetic conditions is unknown. Therefore, we analyzed the impact of α-LA on cell viability and expression of nephrin and zinc finger protein 580 (ZNF580) in normal hPC in vitro...
June 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28601387/guideline-concordant-care-improves-overall-survival-for-locally-advanced-non-small-cell-lung-carcinoma-patients-a-national-cancer-database-analysis
#10
Hiba Z Ahmed, Yuan Liu, Kelli O'Connell, Maaz Z Ahmed, Richard J Cassidy, Theresa W Gillespie, Pretesh Patel, Rathi N Pillai, Madhusmita Behera, Conor E Steuer, Taofeek K Owonikoko, Suresh S Ramalingam, Walter J Curran, Kristin A Higgins
BACKGROUND: Current evidence-based guideline-concordant care (GCC) for locally advanced non-small-cell lung cancer (NSCLC) patients with good performance status is concurrent chemoradiation. In this study we evaluated factors associated with lack of GCC and its effects on overall survival (OS). PATIENTS AND METHODS: Unresectable stage III NSCLC patients, diagnosed from 2005 to 2013 with a Charlson-Deyo score of 0, were identified from the National Cancer Database...
April 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28600763/mycobacterial-load-assay
#11
Stephen H Gillespie, Wilber Sabiiti, Katarina Oravcova
Tuberculosis is a difficult disease to treat, a process made more harder as tools to monitor treatment response only provide a result long after the patient has provided a sample. The mycobacterial load assay (MBLA) provides a simple molecular test to quantify and determine the viability of M. tuberculosis in human or other samples.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28598753/letters-response-to-comment-on-nurses-practice-in-preventing-postoperative-wound-infections-an-observational-study-jwc-january-2017-26-1
#12
Frances Lin, Andrea Marshall, Shuying Ding, Brigid M Gillespie
No abstract text is available yet for this article.
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28596100/aerodynamic-patterns-in-patients-with-voice-disorders-a-retrospective-study
#13
Marina Gilman, Brian Petty, Carissa Maira, Madeleine Pethan, Lijia Wang, Edie R Hapner, Michael M Johns
OBJECTIVE: A recently published retrospective chart review of aerodynamic profiles of women with primary muscle tension dysphonia by Gillespie et al (2013) identified various relationships between mean airflow rate (MFR) and estimated subglottal pressure (est-Psub). The current retrospective study expanded the diagnostic categories to include all voice disorders referred for voice therapy. Three research questions were proposed: (1) Are there differences in the MFR and the est-Psub compared with the normal control group? (2) Within the disordered population, are there different variations in the pairing of MFR and est-Psub? (3) If these variations exist, are they diagnosis specific? METHODS: A retrospective chart review of patients seen for acoustic and aerodynamic voice assessment at the Emory Voice Center between January 1, 2013 and December 31, 2014, were examined for aerodynamic measures of est-Psub and MFR; of these, 192 met the inclusion criteria...
June 5, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28595089/dexamethasone-facilitates-fear-extinction-and-safety-discrimination-in-ptsd-a-placebo-controlled-double-blind-study
#14
Vasiliki Michopoulos, Seth D Norrholm, Jennifer S Stevens, Ebony M Glover, Barbara O Rothbaum, Charles F Gillespie, Ann C Schwartz, Kerry J Ressler, Tanja Jovanovic
Psychophysiological hallmarks of posttraumatic stress disorder (PTSD) include exaggerated fear responses, impaired inhibition and extinction of conditioned fear, and decreased discrimination between safety and fear cues. This increased fear load associated with PTSD can be a barrier to effective therapy thus indicating the need for new treatments to reduce fear expression in people with PTSD. One potential biological target for reducing fear expression in PTSD is the hypothalamic-pituitary-adrenal (HPA) axis, which is dysregulated in PTSD...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28591301/a-grounded-theory-study-of-the-intention-of-nurses-to-leave-the-profession
#15
Leyla Alilu, Vahid Zamanzadeh, Leila Valizadeh, Hosein Habibzadeh, Mark Gillespie
Objective: this study explores the process of the development of an intention to leave bedside nursing. Method: the process was studied from the perspective of 21 nurses using the grounded theory method. Data were collected using semi-structured interviews and the constant comparative method of Corbin and Strauss was used for data analysis. Results: according to the participants, the two main categories, "social image of nursing", and "culture and structure of the bedside", were the contextual factors that influence why nurses are leaving bedside care provision...
June 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28586281/opioid-vs-nonopioid-prescribers-variations-in-care-for-a-standardized-acute-back-pain-case
#16
Kathleen Hanley, Sondra Zabar, Lisa Altshuler, Hillary Lee, Jasmine Ross, Nicomedes Rivera, Christian Marvilli, Colleen Gillespie
BACKGROUND: Opioid analgesics are effective and appropriate therapy for many types of acute pain. Epidemiologic evidence supports a direct relationship between increased opioid prescribing and increases in opioid use disorders and overdoses. OBJECTIVE: To tailor our residency curriculum, we designed and fielded an unannounced standardized patient (USP) case involving a patient with acute back pain who is requesting Vicodin (5/325 mg). We describe residents' case management and examine whether their management decisions, including opioid prescribing, were related to their core clinical skills...
June 6, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28582682/rotator-cuff-related-pain-patients-understanding-and-experiences
#17
Melissa A Gillespie, Aleksandra Mącznik, Craig A Wassinger, Gisela Sole
BACKGROUND: Persistent musculoskeletal pain is a multi-factorial entity, influenced by biological, genetic and psychosocial factors. Psychosocial factors, such as individuals' beliefs and experiences, need to be considered in the management of such pain. While extensive research has explored beliefs of individuals with spinal pain, less is known about individuals' beliefs regarding shoulder pain. OBJECTIVES: To explore beliefs about the cause of pain in individuals with persistent rotator cuff-related pain, as well as the experiences of the effect of pain on their daily lives...
May 27, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28582429/transmission-dynamics-and-control-of-rickettsia-rickettsii-in-populations-of-hydrochoerus-hydrochaeris-and-amblyomma-sculptum
#18
Gina Polo, Carlos Mera Acosta, Marcelo B Labruna, Fernando Ferreira
BACKGROUND: Brazilian Spotted Fever (BSF), caused by the bacterium Rickettsia rickettsii, is the tick-borne disease that generates the largest number of human deaths in the world. In Brazil, the current increase of BSF human cases has been associated with the presence and expansion of capybaras Hydrochoerus hydrochaeris, which act as primary hosts for the tick Amblyomma sculptum, vector of the R. rickettsii in this area. METHODS: We proposed a semi-discrete-time stochastic model to evaluate the role of capybaras in the transmission dynamics of R...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28577923/using-adenosine-tri-phosphate-bioluminescence-to-validate-decontamination-of-endoscopes
#19
Elizabeth Gillespie
The reports of outbreaks involving carbapenemase resistant enterobacteriaceae (CRE) associated with gastrointestinal endoscopy prompted a review and study of a novel method of assessing cleaning. We used adenosinetriphosphate (ATP) bioluminescence to demonstrate cleanliness prior to endoscopy. We compared ATP testing with microbiological monitoring for 127 endoscopes. Samples were taken after cleaning, reprocessing and storage, but immediately before the endoscopy procedure. We recommend implementing ATP testing prior to endoscopy procedures as an alternative to microbiological testing at periodic intervals...
May 31, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28566892/disruptive-behavior-in-the-workplace-challenges-for-gastroenterology-fellows
#20
Nalinee Srisarajivakul, Catherine Lucero, Xiao-Jing Wang, Michael Poles, Colleen Gillespie, Sondra Zabar, Elizabeth Weinshel, Lisa Malter
AIM: To assess first-year gastroenterology fellows' ability to address difficult interpersonal situations in the workplace using objective structured clinical examinations (OSCE). METHODS: Two OSCEs ("distracted care team" and "frazzled intern") were created to assess response to disruptive behavior. In case 1, a fellow used a colonoscopy simulator while interacting with a standardized patient (SP), nurse, and attending physician all played by actors. The nurse and attending were instructed to display specific disruptive behavior and disregard the fellow unless requested to stop the disruptive behavior and focus on the patient and procedure...
May 14, 2017: World Journal of Gastroenterology: WJG
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