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https://www.readbyqxmd.com/read/28209636/a-randomized-crossover-trial-of-dietary-sodium-restriction-in-stage-3-4-ckd
#1
Rajiv Saran, Robin L Padilla, Brenda W Gillespie, Michael Heung, Scott L Hummel, Vimal Kumar Derebail, Bertram Pitt, Nathan W Levin, Fansan Zhu, Samer R Abbas, Li Liu, Peter Kotanko, Philip Klemmer
BACKGROUND AND OBJECTIVES: Patients with chronic kidney disease (CKD) are often volume expanded and hypertensive. Few controlled studies have assessed the effects of a sodium-restricted diet (SRD) in CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a randomized crossover trial to evaluate the effect of SRD (target <2 g sodium per day) versus usual diet on hydration status (by bioelectrical impedance spectroscopy) and blood pressure (BP) between May of 2009 and May of 2013...
February 16, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28206905/discovery-of-a-novel-alphavirus-related-to-eilat-virus
#2
Kyra Hermanns, Florian Zirkel, Anne Kopp, Marco Marklewitz, Innocent B Rwego, Alejandro Estrada, Thomas R Gillespie, Christian Drosten, Sandra Junglen
Most alphaviruses are transmitted by arthropods and infect vertebrate hosts. An exception is Eilat virus (EILV), the only described alphavirus with a host range restricted to insects. We established a new generic reverse transcription PCR assay for alphaviruses and tested 8860 tropical mosquitoes. We detected a novel alphavirus, tentatively named Taï Forest alphavirus (TALV), in Culex decens mosquitoes collected in Ivory Coast. The full genome was sequenced, and closest similarity was found to EILV. Pairwise amino acid identities to EILV ranged between 67 and 88 % for the corresponding proteins, suggesting that TALV defines a proposed new alphavirus species...
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28203289/epidemiological-molecular-characterization-and-antibiotic-resistance-of-salmonella-enterica-serovars-isolated-from-chicken-farms-in-egypt
#3
Hanem El-Sharkawy, Amin Tahoun, Abd El-Galiel A El-Gohary, Moshira El-Abasy, Fares El-Khayat, Trudi Gillespie, Yukio Kitade, Hafez M Hafez, Heinrich Neubauer, Hosny El-Adawy
BACKGROUND: Salmonella is one of major causes of foodborne outbreaks globally. This study was conducted to estimate the prevalence, typing and antibiotic susceptibilities of Salmonella enterica serovars isolated from 41 broiler chicken farms located in Kafr El-Sheikh Province in Northern Egypt during 2014-2015. The clinical signs and mortalities were observed. RESULTS: In total 615 clinical samples were collected from broiler flocks from different organs (liver, intestinal content and gall bladder)...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28198964/a-qualitative-exploration-of-facilitators-and-inhibitors-influencing-nurses-intention-to-leave-clinical-nursing
#4
Leyla Alilu, Leila Valizadeh, Vahid Zamanzadeh, Hosein Habibzadeh, Mark Gillespie
OBJECTIVE: The aim of this study was to determine the barriers and facilitators shaping the development of an intent to leave the nursing profession, from the perspective of Iran's clinical nurses. METHOD: The study was completed using qualitative content analysis And included 21 Participants who were clinical nurses with a variety of work experience across a range of clinical posts. Semi-structured interviews were used to collect data and data obtained from the interviews were analyzed and interpreted utilizing a content analysis method...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28197323/novel-2-substituted-7-azaindole-and-7-azaindazole-analogues-as-potential-antiviral-agents-for-the-treatment-of-influenza
#5
Upul K Bandarage, Michael P Clark, Emanuele Perola, Huai Gao, Marc D Jacobs, Alice Tsai, Jeffery Gillespie, Joseph M Kennedy, François Maltais, Mark W Ledeboer, Ioana Davies, Wenxin Gu, Randal A Byrn, Kwame Nti Addae, Hamilton Bennett, Joshua R Leeman, Steven M Jones, Colleen O'Brien, Christine Memmott, Youssef Bennani, Paul S Charifson
JNJ-63623872 (2) is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on 1,3-diaminocyclohexyl amide and urea substitutions on the pyrimidine-7-azaindole motif. In this work, we explored two strategies to eliminate observed aldehyde oxidase (AO)-mediated metabolism at the 2-position of these 7-azaindole analogues. Substitution at the 2-position of the azaindole ring generated somewhat less potent analogues, but reduced AO-mediated metabolism...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28194999/upper-airway-stimulation-for-obstructive-sleep-apnea
#6
M Boyd Gillespie, Ryan J Soose, B Tucker Woodson, Kingman P Strohl, Joachim T Maurer, Nico de Vries, David L Steward, Jonathan Z Baskin, M Safwan Badr, Ho-Sheng Lin, Tapan A Padhya, Sam Mickelson, W McDowell Anderson, Olivier M Vanderveken, Patrick J Strollo
Objective To assess patient-based outcomes of participants in a large cohort study-the STAR trial (Stimulation Therapy for Apnea Reduction)-48 months after implantation with an upper airway stimulation system for moderate to severe obstructive sleep apnea. Study Design A multicenter prospective cohort study. Setting Industry-supported multicenter academic and clinical setting. Subjects Participants (n = 91) at 48 months from a cohort of 126 implanted participants. Methods A total of 126 participants received an implanted upper airway stimulation system in a prospective phase III trial...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28187957/discovery-of-n-2-aminoethyl-n-benzyloxyphenyl-benzamides-new-potent-trypanosoma-brucei-inhibitors
#7
Andriy Buchynskyy, J Robert Gillespie, Matthew A Hulverson, Joshua McQueen, Sharon A Creason, Ranae M Ranade, Nicole A Duster, Michael H Gelb, Frederick S Buckner
A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-phenyl benzamides as a starting point for hit-to-lead medicinal chemistry. Eighty two analogues were prepared, which led to the identification of a set of highly potent N-(2-aminoethyl)-N-benzyloxyphenyl benzamides with the most potent compound 73 having an in vitro EC50=0.001μM. The compounds displayed drug-like properties when tested in a number of in vitro assays...
November 12, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28185314/beta-3-adrenergic-receptor-is-expressed-in-acetylcholine-containing-nerve-fibers-of-the-human-urinary-bladder-an-immunohistochemical-study
#8
Ana Coelho, Tiago Antunes-Lopes, James Gillespie, Francisco Cruz
AIMS: To identify in the human bladder the structures which express the Beta-3 adrenoceptor (β3AR). METHODS: Human bladders from cadaveric organ donors (equally balanced in sex and age) were collected. Bladders were immediately fixed in paraformaldehyde and further processed for cryostat sectioning. Single and double immunohistochemistry was performed using antibodies against β3AR C-terminal, β3AR N-terminal, a pan-neuronal marker (β3-Tubulin) and markers of cholinergic (Vesicular Acetylcholine Transporter), adrenergic (Tyrosine Hidroxylase), and peptidergic (Calcitonin Gene-Related Peptide) nerve fibers...
February 10, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28173952/diversity-a-key-aspect-of-21st-century-faculty-roles
#9
Jacquelyn Y Taylor, Gordon Gillespie
No abstract text is available yet for this article.
January 17, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28166199/klf6-depletion-promotes-nf-%C3%AE%C2%BAb-signaling-in-glioblastoma
#10
A P Masilamani, R Ferrarese, E Kling, N K Thudi, H Kim, D M Scholtens, F Dai, M Hadler, T Unterkircher, L Platania, A Weyerbrock, M Prinz, G Y Gillespie, G R Harsh Iv, M Bredel, M S Carro
Dysregulation of the NF-κB transcription factor occurs in many cancer types. Krüppel-like family of transcription factors (KLFs) regulate the expression of genes involved in cell proliferation, differentiation and survival. Here, we report a new mechanism of NF-κB activation in glioblastoma through depletion of the KLF6 tumor suppressor. We show that KLF6 transactivates multiple genes negatively controlling the NF-κB pathway and consequently reduces NF-κB nuclear localization and downregulates NF-κB targets...
February 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28164461/flexible-polygon-mirror-based-laser-scanning-microscope-platform-for-multiphoton-in-vivo-imaging
#11
Y X Li, V Gautam, A Brüstle, I A Cockburn, V R Daria, C Gillespie, K Gaus, C Alt, W M Lee
Commercial microscopy systems make use of tandem scanning i.e. either slow or fast scanning. We constructed, for the first time, an advanced control system capable of delivering a dynamic line scanning speed ranging from 2.7 kHz to 27 kHz and achieve variable frame rates from 5 Hz to 50 Hz (512 × 512). The dynamic scanning ability is digitally controlled by a new customized open-source software named PScan1.0. This permits manipulation of scanning rates either to gain higher fluorescence signal at slow frame rate without increasing laser power or increase frame rates to capture high speed events...
February 6, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28147534/estimating-rare-events-in-biochemical-systems-using-conditional-sampling
#12
V S Sundar
The paper focuses on development of variance reduction strategies to estimate rare events in biochemical systems. Obtaining this probability using brute force Monte Carlo simulations in conjunction with the stochastic simulation algorithm (Gillespie's method) is computationally prohibitive. To circumvent this, important sampling tools such as the weighted stochastic simulation algorithm and the doubly weighted stochastic simulation algorithm have been proposed. However, these strategies require an additional step of determining the important region to sample from, which is not straightforward for most of the problems...
January 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28137931/correlates-of-non-technical-skills-in-surgery-a-prospective-study
#13
Brigid M Gillespie, Emma Harbeck, Evelyn Kang, Catherine Steel, Nicole Fairweather, Wendy Chaboyer
BACKGROUND: Communication and teamwork failures have frequently been identified as the root cause of adverse events and complications in surgery. Few studies have examined contextual factors that influence teams' non-technical skills (NTS) in surgery. The purpose of this prospective study was to identify and describe correlates of NTS. METHODS: We assessed NTS of teams and professional role at 2 hospitals using the revised 23-item Non-TECHnical Skills (NOTECHS) and its subscales (communication, situational awareness, team skills, leadership and decision-making)...
January 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28137488/patient-characteristics-associated-with-poor-inhaler-technique-among-a-cohort-of-patients-with-copd
#14
Anne C Melzer, Bijan J Ghassemieh, Suzanne E Gillespie, Peter K Lindenauer, Mary Ann McBurnie, Richard A Mularski, Edward T Naureckas, William M Vollmer, David H Au
BACKGROUND: Inhaled therapies are the cornerstone of pharmacologic management for COPD. Each device requires a unique series of steps to be most effective, making appropriate instruction in inhaler technique a key part of the management of COPD. OBJECTIVES: Examine characteristics of patients and devices associated with poor technique among patients with COPD. METHODS: Cross-sectional study of subjects with COPD using at least one of: metered dose inhaler, Advair Diskus, Spiriva Handihaler, identified from the COPD Outcomes-based Network for Clinical Effectiveness and Research Translation (CONCERT) registry...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28132754/interventional-pulmonology-fellowship-accreditation-standards-executive-summary-of-the-multi-society-interventional-pulmonology-fellowship-accreditation-committee
#15
John J Mullon, Kristin M Burkart, Gerard Silvestri, D Kyle Hogarth, Francisco Almeida, David Berkowitz, George Eapen, David Feller-Kopman, Henry E Fessler, Erik Folch, Colin Gillespie, Andrew Haas, Shaheen Islam, Carla Lamb, Stephanie M Levine, Adnan Majid, Fabien Maldonado, Ali Musani, Craig Piquette, Cynthia Ray, Chakravarthy Reddy, Otis Rickman, Michael Simoff, Momen M Wahidi, Hans Lee
Interventional Pulmonology (IP) is a rapidly evolving subspecialty of pulmonary medicine. In the last ten years formal IP fellowships have increased substantially in number from just five to now over thirty. The vast majority of IP fellowship trainees are selected through the National Residency Matching Program, and validated in-service and certification exams for IP exist. Practice standards and training guidelines for IP fellowship programs have been published, however considerable variability in the environment, curriculum, and experience offered by the various fellowship programs still exists and there is currently no formal accreditation process in place to standardize IP fellowship training...
January 26, 2017: Chest
https://www.readbyqxmd.com/read/28132583/the-evolving-role-of-oral-hormonal-therapies-and-review-of-conjugated-estrogens-bazedoxifene-for-the-management-of-menopausal-symptoms
#16
Sharon J Parish, John A Gillespie
This review describes the evolving role of oral hormone therapy (HT) for treating menopausal symptoms and preventing osteoporosis, focusing on conjugated estrogens/bazedoxifene (CE/BZA). Estrogens alleviate hot flushes and prevent bone loss associated with menopause. In nonhysterectomized women, a progestin should be added to estrogens to reduce the risk of endometrial cancer. Use of HT declined since the Women's Health Initiative (WHI) studies showed that HT does not prevent coronary heart disease (CHD) and that conjugated estrogens/medroxyprogesterone acetate increased the risk of invasive breast cancer after nearly 5 years of use...
January 30, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28132547/student-nurse-preferences-for-their-first-clinical-experience-a-thematic-analysis
#17
Mark Gillespie
Shifts in demographic profiles and in the understanding of how to best deliver health care have seen nurses increasingly caring for non-acute client groups outside traditional clinical settings. Evidence suggests that this does not always sit well with nurses, or with nurses in training. This study sought to investigate the influences on student nurse perceptions of the worth of working with various client groups. Thematic analysis of a focus group discussion led to the identification of several themes suggesting that unhelpful opinions are present in some students on entry to the programme; however, programme-related influences also contribute towards unhelpful attitudes...
January 26, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28126306/the-impact-of-radiation-oncologists-on-the-early-adoption-of-hypofractionated-radiation-therapy-for-early-stage-breast-cancer
#18
Isabel J Boero, Erin F Gillespie, Jiayi Hou, Anthony J Paravati, Ellen Kim, John P Einck, Catheryn Yashar, Loren K Mell, James D Murphy
PURPOSE: Despite multiple randomized trials showing the efficacy of hypofractionated radiation therapy in early-stage breast cancer, the United States has been slow to adopt this treatment. The goal of this study was to evaluate the impact of individual radiation oncologists on the early adoption of hypofractionated radiation therapy for early-stage breast cancer. METHODS: We identified 22,233 Medicare beneficiaries with localized breast cancer that was diagnosed from 2004 to 2011 who underwent breast-conserving surgery with adjuvant radiation...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28125528/mitochondrial-dna-damage-initiates-acute-lung-injury-and-multi-organ-system-failure-evoked-in-rats-by-intra-tracheal-pseudomonas-aeruginosa
#19
Yann-Leei Lee, Boniface Obiako, Olena M Gorodnya, Mykhaylo V Ruchko, Jamie L Kuck, Viktor M Pastukh, Glenn L Wilson, Jon D Simmons, Mark N Gillespie
Although studies in rat cultured pulmonary artery endothelial cells, perfused lungs, and intact mice support the concept that oxidative mitochondrial (mt) DNA damage triggers acute lung injury (ALI), it has not yet been determined whether enhanced mtDNA repair forestalls development of ALI and its progression to multiple organ system failure (MOSF). Accordingly, here we examined the effect of a fusion protein construct targeting the DNA glycosylase, Ogg1, to mitochondria in a rat model intra-tracheal P. aeruginosa (strain 103; PA103)-induced ALI and MOSF...
January 25, 2017: Shock
https://www.readbyqxmd.com/read/28122885/heart-disease-and-stroke-statistics-2017-update-a-report-from-the-american-heart-association
#20
Emelia J Benjamin, Michael J Blaha, Stephanie E Chiuve, Mary Cushman, Sandeep R Das, Rajat Deo, Sarah D de Ferranti, James Floyd, Myriam Fornage, Cathleen Gillespie, Carmen R Isasi, Monik C Jiménez, Lori Chaffin Jordan, Suzanne E Judd, Daniel Lackland, Judith H Lichtman, Lynda Lisabeth, Simin Liu, Chris T Longenecker, Rachel H Mackey, Kunihiro Matsushita, Dariush Mozaffarian, Michael E Mussolino, Khurram Nasir, Robert W Neumar, Latha Palaniappan, Dilip K Pandey, Ravi R Thiagarajan, Mathew J Reeves, Matthew Ritchey, Carlos J Rodriguez, Gregory A Roth, Wayne D Rosamond, Comilla Sasson, Amytis Towfighi, Connie W Tsao, Melanie B Turner, Salim S Virani, Jenifer H Voeks, Joshua Z Willey, John T Wilkins, Jason Hy Wu, Heather M Alger, Sally S Wong, Paul Muntner
No abstract text is available yet for this article.
January 25, 2017: Circulation
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