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https://www.readbyqxmd.com/read/28441045/effects-of-topical-application-of-silver-sulfadiazine-cream-triple-antimicrobial-ointment-or-hyperosmolar-nanoemulsion-on-wound-healing-bacterial-load-and-exuberant-granulation-tissue-formation-in-bandaged-full-thickness-equine-skin-wounds
#1
Caroline C Gillespie Harmon, Jan F Hawkins, Jianming Li, Sean Connell, Margaret Miller, Megan Saenger, Lynetta J Freeman
OBJECTIVE To determine the effects of 3 topically applied treatments (1% silver sulfadiazine cream [SSC], triple antimicrobial ointment [TAO], and hyperosmolar nanoemulsion [HNE]) on microbial counts, exuberant granulation tissue (EGT) development, and reepithelialization of contaminated wounds at the distal aspect of the limbs of horses. ANIMALS 8 healthy adult horses. PROCEDURES A 2.5 × 2.5-cm, full-thickness, cutaneous wound was created at the dorsal aspect of each metacarpus and metatarsus (1 wound/limb/horse), covered with nonadhesive dressing, and bandaged...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28438921/null-expectations-for-disease-dynamics-in-shrinking-habitat-dilution-or-amplification
#2
Christina L Faust, Andrew P Dobson, Nicole Gottdenker, Laura S P Bloomfield, Hamish I McCallum, Thomas R Gillespie, Maria Diuk-Wasser, Raina K Plowright
As biodiversity declines with anthropogenic land-use change, it is increasingly important to understand how changing biodiversity affects infectious disease risk. The dilution effect hypothesis, which points to decreases in biodiversity as critical to an increase in infection risk, has received considerable attention due to the allure of a win-win scenario for conservation and human well-being. Yet some empirical data suggest that the dilution effect is not a generalizable phenomenon. We explore the response of pathogen transmission dynamics to changes in biodiversity that are driven by habitat loss using an allometrically scaled multi-host model...
June 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28438166/adjacent-regenerative-peripheral-nerve-interfaces-produce-phase-antagonist-signals-during-voluntary-walking-in-rats
#3
Daniel Ursu, Andrej Nedic, Melanie Urbanchek, Paul Cederna, R Brent Gillespie
BACKGROUND: Regenerative Peripheral Nerve Interfaces (RPNIs) are neurotized muscle grafts intended to produce electromyographic signals suitable for motorized prosthesis control. Two RPNIs producing independent agonist/antagonist signals are required for each control axis; however, it is unknown whether signals from adjacent RPNIs are independent. The purpose of this work was to determine signaling characteristics from two adjacent RPNIs, the first neurotized by a foot dorsi-flexor nerve and the second neurotized by a foot plantar-flexor nerve in a rodent model...
April 24, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28435283/unlocking-the-black-box-of-practice-improvement-strategies-to-implement-surgical-safety-checklists-a-process-evaluation
#4
Brigid M Gillespie, Kyra Hamilton, Dianne Ball, Joanne Lavin, Therese Gardiner, Teresa K Withers, Andrea P Marshall
BACKGROUND: Compliance with surgical safety checklists (SSCs) has been associated with improvements in clinical processes such as antibiotic use, correct site marking, and overall safety processes. Yet, proper execution has been difficult to achieve. OBJECTIVES: The objective of this study was to undertake a process evaluation of four knowledge translation (KT) strategies used to implement the Pass the Baton (PTB) intervention which was designed to improve utilization of the SSC...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28434918/forming-and-activating-an-internal-facilitation-group-for-successful-implementation-a-qualitative-study
#5
Megan B McCullough, Chris Gillespie, Beth Ann Petrakis, Ellen A Jones, Angela M Park, Carol VanDeusen Lukas, Adam J Rose
BACKGROUND: This study focuses on an implementation facilitation strategy to improve the delivery of anticoagulation care within pharmacy-run clinics across 8 Veterans Health Administration (VA) medical centers. Other studies have explored various models of implementation facilitation, including external facilitation (EF), internal facilitation (IF), and blended facilitation (BF) combining both approaches. This study focuses on the use of an internal facilitation team of anticoagulation coordinators representing 8 VA anticoagulation clinics to enhance the implementation process...
April 9, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28428851/screening-mitochondrial-dna-sequence-variation-as-an-alternative-method-for-tracking-established-and-outbreak-populations-of-queensland-fruit-fly-at-the-species-southern-range-limit
#6
Mark J Blacket, Mali B Malipatil, Linda Semeraro, Peter S Gillespie, Bernie C Dominiak
Understanding the relationship between incursions of insect pests and established populations is critical to implementing effective control. Studies of genetic variation can provide powerful tools to examine potential invasion pathways and longevity of individual pest outbreaks. The major fruit fly pest in eastern Australia, Queensland fruit fly Bactrocera tryoni (Froggatt), has been subject to significant long-term quarantine and population reduction control measures in the major horticulture production areas of southeastern Australia, at the species southern range limit...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28427904/leishmania-donovani-tyrosyl-trna-synthetase-structure-in-complex-with-a-tyrosyl-adenylate-analog-and-comparisons-with-human-and-protozoan-counterparts
#7
Ximena Barros-Álvarez, Keshia M Kerchner, Cho Yeow Koh, Stewart Turley, Els Pardon, Jan Steyaert, Ranae M Ranade, J Robert Gillespie, Zhongsheng Zhang, Christophe L M J Verlinde, Erkang Fan, Frederick S Buckner, Wim G J Hol
The crystal structure of Leishmania donovani tyrosyl-tRNA synthetase (LdTyrRS) in complex with a nanobody and the tyrosyl adenylate analog TyrSA was determined at 2.75 Å resolution. Nanobodies are the variable domains of camelid heavy chain-only antibodies. The nanobody makes numerous crystal contacts and in addition reduces the flexibility of a loop of LdTyrRS. TyrSA is engaged in many interactions with active site residues occupying the tyrosine and adenine binding pockets. The LdTyrRS polypeptide chain consists of two pseudo-monomers, each consisting of two domains...
April 17, 2017: Biochimie
https://www.readbyqxmd.com/read/28426694/prediction-of-atherosclerotic-cardiovascular-disease-mortality-in-a-nationally-representative-cohort-using-a-set-of-risk-factors-from-pooled-cohort-risk-equations
#8
Zefeng Zhang, Cathleen Gillespie, Barbara Bowman, Quanhe Yang
The American College of Cardiology/American Heart Association developed Pooled Cohort equations to estimate atherosclerotic cardiovascular disease (ASCVD) risk. It is unclear how well the equations predict ASCVD mortality in a nationally representative cohort. We used the National Health and Nutrition Examination Survey (NHANES) 1988-1994 and Linked Mortality through 2006 (n = 6,644). Among participants aged 40-79 years without ASCVD at baseline, we used Cox proportional hazard models to estimate the 10-year probability of ASCVD death by sex and race-ethnicity (non-Hispanic white (NHW), non-Hispanic black (NHB) and Mexican American (MA))...
2017: PloS One
https://www.readbyqxmd.com/read/28426344/primary-pediatric-breast-lesions-comparing-the-prevalence-of-malignancies-in-the-middle-east-with-north-america-review-of-1031-cases
#9
Justine S Broecker, Nasim Khoshnam, Laura Thompson, Shady Anis, Nora Kamal, Scott Gillespie, Diana Kantarovich, Diana Metry, Mary Pate Mills, Rachel Drummey, Brianna Williams, Bahig M Shehata
Benign breast masses are uncommon but are becoming more recognized among the pediatric population. Malignant breast lesions are very rare. The aim of our study was to review and compare the demographics, clinical presentation, treatment, and outcomes of breast lesions, including primary malignancies, and to discuss theories that may explain why there is an increased rate of breast cancers diagnosed at a younger age in the Egyptian population. A total of 1031 cases were reviewed. Comparisons were made between the Egyptian (n = 846) and US (n = 185) cohorts...
April 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28424107/early-maturation-and-substance-use-across-adolescence-and-young-adulthood-a-longitudinal-study-of-finnish-twins
#10
Jeanne E Savage, Richard J Rose, Lea Pulkkinen, Karri Silventoinen, Tellervo Korhonen, Jaakko Kaprio, Nathan Gillespie, Danielle M Dick
Early maturation, indexed by pubertal development (PD), has been associated with earlier initiation and greater frequency of adolescent substance use, but this relationship may be biased by confounding factors and effects that change across development. Using a population-based Finnish twin sample (N = 3,632 individuals), we conducted twin modeling and multilevel structural equation modeling of the relationship between PD and substance use at ages 12-22. Shared environmental factors contributed to early PD and heavier substance use for females...
April 20, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28417336/treatment-of-depression-in-adults-with-fabry-disease
#11
Nadia Ali, Scott Gillespie, Dawn Laney
Fabry disease (FD) is a genetic X-linked, multisystemic, progressive lysosomal storage disorder (LSD). Depression has emerged as a disease complication, with prevalence estimates ranging from 15 to 62%. This is a pilot study examining the effects of psychological counseling for depression in FD on depression, adaptive functioning (AF), quality of life (QOL), and subjective pain experience. Telecounseling was also piloted, as it has beneficial effects in other chronic diseases which make in-person counseling problematic...
April 18, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28415290/backward-stochastic-differential-equation-approach-to-modeling-of-gene-expression
#12
Evelina Shamarova, Roman Chertovskih, Alexandre F Ramos, Paulo Aguiar
In this article, we introduce a backward method to model stochastic gene expression and protein-level dynamics. The protein amount is regarded as a diffusion process and is described by a backward stochastic differential equation (BSDE). Unlike many other SDE techniques proposed in the literature, the BSDE method is backward in time; that is, instead of initial conditions it requires the specification of end-point ("final") conditions, in addition to the model parametrization. To validate our approach we employ Gillespie's stochastic simulation algorithm (SSA) to generate (forward) benchmark data, according to predefined gene network models...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28410862/state-level-awareness-of-chronic-kidney-disease-in-the-u-s
#13
Sai H Dharmarajan, Jennifer L Bragg-Gresham, Hal Morgenstern, Brenda W Gillespie, Yi Li, Neil R Powe, Delphine S Tuot, Tanushree Banerjee, Nilka Ríos Burrows, Deborah B Rolka, Sharon H Saydah, Rajiv Saran
INTRODUCTION: This study examined state-level variation in chronic kidney disease (CKD) awareness using national estimates of disease awareness among adults in the U.S. with CKD. METHODS: Data on U.S. adults were obtained from two national, population-based surveys: (1) the Behavioral Risk Factor Surveillance System (BRFSS 2011; n=506,467), a state-level phone survey containing information on self-reported kidney disease; and (2) the National Health and Nutrition Examination Survey (NHANES 2005-2012; n=20,831), containing physical health examination, surveys containing data on self-reported kidney disease, risk factors, and laboratory values...
April 11, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28408215/prevalence-genetic-diversity-and-potential-clinical-impact-of-blood-borne-and-enteric-protozoan-parasites-in-native-mammals-from-northern-australia
#14
Amanda Barbosa, Andrea Reiss, Bethany Jackson, Kristin Warren, Andrea Paparini, Graeme Gillespie, Danielle Stokeld, Peter Irwin, Una Ryan
A molecular survey was conducted to provide baseline information on the prevalence, genetic diversity and potential clinical impacts of blood-borne and enteric protozoans in native wild mammals from the Northern Territory (NT). A total of 209 blood and 167 faecal samples were collected from four target species; the northern brown bandicoot (Isoodon macrourus), common brushtail possum (Trichosurus vulpecula), northern quoll (Dasyurus hallucatus) and brush-tailed rabbit-rat (Conilurus penicillatus). Blood samples were screened by PCR at the 18S rRNA gene for trypanosomes, piroplasms and haemogregarines, with faecal samples tested for Cryptosporidium spp...
April 4, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28408039/binocular-measures-of-visual-acuity-and-visual-field-versus-binocular-approximations
#15
David C Musch, Leslie M Niziol, Brenda W Gillespie, Paul R Lichter, Nancy K Janz
PURPOSE: To assess the relationship of binocular visual function tests with binocular approximations using data from the Collaborative Initial Glaucoma Treatment Study (CIGTS). DESIGN: Case series based on existing data from a clinical trial. PARTICIPANTS: Six hundred seven patients with newly diagnosed open-angle glaucoma from the CIGTS. METHODS: Monocular visual field (VF) and visual acuity (VA) tests were performed at baseline and every 6 months thereafter...
April 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28407272/the-relative-effects-of-reproductive-condition-stress-and-seasonality-on-patterns-of-parasitism-in-wild-female-black-howler-monkeys-alouatta-pigra
#16
Rodolfo Martínez-Mota, Paul A Garber, Rupert Palme, Thomas R Gillespie
Parasitic infections in wildlife are shaped by host-related traits including individual reproductive condition. It has been argued that female primates are more susceptible to infectious diseases during pregnancy due to short-term changes in immune function that result in reduced ability to combat infections. Likewise, lactation, which is the most energetically expensive state, may affect immunity and infection risk due to tradeoffs between milk production and maintenance of immune function. Here, we examine the degree to which parasite prevalence and parasite richness are affected by female reproductive condition and stress levels in wild female black howler monkeys (Alouatta pigra)...
April 13, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28406996/ultrasensitivity-and-fluctuations-in-the-barkai-leibler-model-of-chemotaxis-receptors-in-escherichia-coli
#17
Ushasi Roy, Manoj Gopalakrishnan
A stochastic version of the Barkai-Leibler model of chemotaxis receptors in Escherichia coli is studied here with the goal of elucidating the effects of intrinsic network noise in their conformational dynamics. The model was originally proposed to explain the robust and near-perfect adaptation of E. coli observed across a wide range of spatially uniform attractant/repellent (ligand) concentrations. In the model, a receptor is either active or inactive and can stochastically switch between the two states. The enzyme CheR methylates inactive receptors while CheB demethylates active receptors and the probability for a receptor to be active depends on its level of methylation and ligand occupation...
2017: PloS One
https://www.readbyqxmd.com/read/28400742/whose-expertise-is-it-evidence-for-autistic-adults-as-critical-autism-experts
#18
Kristen Gillespie-Lynch, Steven K Kapp, Patricia J Brooks, Jonathan Pickens, Ben Schwartzman
Autistic and non-autistic adults' agreement with scientific knowledge about autism, how they define autism, and their endorsement of stigmatizing conceptions of autism has not previously been examined. Using an online survey, we assessed autism knowledge and stigma among 636 adults with varied relationships to autism, including autistic people and nuclear family members. Autistic participants exhibited more scientifically based knowledge than others. They were more likely to describe autism experientially or as a neutral difference, and more often opposed the medical model...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28398087/nurses-on-the-move-robert-wood-johnson-foundation-nurse-faculty-scholars-and-their-action-on-the-social-determinants-of-health
#19
Yolanda Ogbolu, Jodi Ford, Elizabeth Cohn, Gordon Lee Gillespie
OBJECTIVE: Medical care alone cannot adequately improve population health or eliminate inequities; social determinants of health (SDH) must be addressed. This study's purpose was to describe the research, teaching, service, and clinical practice activities implemented by RWJF Nurse Faculty Scholars to act on the SDH. DESIGN: A cross-sectional survey design was used with a sample of RWJF Nurse Faculty Scholars, chosen because they were provided specialized mentoring, grants, and other support that allowed them to explore SDH...
April 11, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28392179/how-do-patients-experience-caring-scoping-review
#20
REVIEW
Hannah Gillespie, Martina Kelly, Sarah Duggan, Tim Dornan
OBJECTIVE: Summarise empirical research into patients' experiences of caring in order to promote this as a core condition for the work of health professionals. METHODS: A review team: carried out a scoping review with a phenomenological orientation that did not privilege any profession or context of care; comprehensively searched six databases from inception to the present, including all English language articles that report patients' lived experiences of caring; and identified and contrasted uncaring experiences...
March 31, 2017: Patient Education and Counseling
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