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https://www.readbyqxmd.com/read/29232479/metabolomic-pathways-to-osteoporosis-in-middle-aged-women-a-genome-metabolome-wide-mendelian-randomization-study
#1
Alireza Moayyeri, Ching-Lung Cheung, Kathryn Cb Tan, John A Morris, Agustin Cerani, Robert P Mohney, J Brent Richard, Christopher Hammond, Tim D Spector, Cristina Menni
The metabolic state of the body can be a major determinant of bone health. We used a Mendelian Randomization approach to identify metabolites causally associated with bone mass to better understand the biological mechanisms of osteoporosis. We tested bone phenotypes (femoral neck, total hip, and lumbar spine BMD) for association with 280 fasting blood metabolites in 6055 women from TwinsUK cohort with genome-wide genotyping scans. Causal associations between metabolites and bone phenotypes were further assessed in a bidirectional Mendelian Randomization study using genetic markers/scores as instrumental variables...
December 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29232003/molecular-dynamics-insights-into-the-structure-function-and-substrate-binding-mechanism-of-mucin-desulfating-sulfatase-of-gut-microbe-bacteroides-fragilis
#2
Ardhendu Bhusan Praharaj, Budheswar Dehury, Namita Mahapatra, Shantanu Kumar Kar, Santosh Kumar Behera
The complex and dynamic consortia of microbiota that harbors the human gastrointestinal tract contributes ominously to the maintenance of health, the onset and progression of diverse spectrum of disorders. The capability of these enteric microbes to bloom within the gut mucosal milieu is often associated to the glycan metabolism of mucin-degrading bacteria. Accruing evidences suggests that the desulfation of mucin is a rate-limiting step in mucin degradation mechanism by colonic bacterial mucin-desulfating sulfatase enzymes (MDS) enzymes...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231788/the-2018-inter-agency-field-manual-on-reproductive-health-in-humanitarian-settings-revising-the-global-standards
#3
Angel M Foster, Dabney P Evans, Melissa Garcia, Sarah Knaster, Sandra Krause, Therese McGinn, Sarah Rich, Meera Shah, Hannah Tappis, Erin Wheeler
Since the 1990s, the Inter-agency field manual on reproductive health in humanitarian settings (IAFM) has provided authoritative guidance on reproductive health service provision during different phases of complex humanitarian emergencies. In 2018, the Inter-Agency Working Group on Reproductive Health in Crises will release a new edition of this global resource. In this article, we describe the collaborative and inter-sectoral revision process and highlight major changes in the 2018 IAFM. Key revisions to the manual include repositioning unintended pregnancy prevention within and explicitly incorporating safe abortion care into the Minimum Initial Service Package (MISP) chapter, which outlines a set of priority activities to be implemented at the outset of a humanitarian crisis; stronger guidance on the transition from the MISP to comprehensive sexual and reproductive health services; and the addition of a logistics chapter...
December 12, 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29231252/lncrna-ccat1-contributes-to-the-growth-and-invasion-of-gastric-cancer-via-targeting-mir-219-1
#4
Yanfeng Li, Guanyu Zhu, Yan Ma, Hongyan Qu
Gastric cancer (GC) is one of the most malignant tumors that seriously threaten to human health. Increased reports indicated that long non-coding RNAs (lncRNAs) were associated with GC. This study aims to investigate the regulatory role of colon cancer associated transcript-1 (CCAT1) in GC. The results exhibited that CCAT1 was higher expressed in 57 GC tissue samples than in 57 paired adjacent normal tissue samples. The expression of CCAT1 was also increased in GC cell lines (MKN45, Hs746T and SGC-7901) compared with gastric epithelial cell line GES-1...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29230317/feasibility-and-acceptability-of-a-universal-screening-and-referral-protocol-for-gender-based-violence-with-women-seeking-care-in-health-clinics-in-dadaab-refugee-camps-in-kenya
#5
A Vu, A L Wirtz, S Bundgaard, A Nair, G Luttah, S Ngugi, N Glass
Background: Gender-based violence (GBV) is both a global public health problem and violation of human rights. Refugees and internally displaced persons experience an increased risk of GBV and health outcomes associated with GBV are often exacerbated in conflict settings. Methods: A mixed methods study to examine the feasibility and acceptability of universal screening for GBV in a refugee population in the Dadaab refugee camp of Kenya, using the ASIST-GBV from January to July 2015...
2017: Global Mental Health
https://www.readbyqxmd.com/read/29226789/the-emotional-distress-of-asylum-seekers-in-israel-and-the-characteristics-of-those-seeking-psychiatric-versus-medical-help
#6
Naama Kiat, Rafael Youngmann, Ido Lurie
Israel has become a destination for asylum seekers. Asylum seekers often experience emotional distress, but have limited access to health services and rarely use psychiatric services. This study sought to understand and characterize the use of psychiatric versus medical services by asylum seekers in Israel. We compared the emotional distress, stressful life events and previous treatment consultations of 21 psychiatric service users (PSU) and 55 medical service users (MSU) at the Open Clinic of Physicians for Human Rights in Tel-Aviv...
October 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29225952/thirty-year-trends-in-the-prevalence-and-severity-of-female-genital-mutilation-a-comparison-of-22-countries
#7
Alissa Koski, Jody Heymann
Introduction: Female genital mutilation (FGM) harms women's health and well-being and is widely considered a violation of human rights. The United Nations has called for elimination of the practice by 2030. Methods: We used household survey data to measure trends in the prevalence of FGM in 22 countries. We also examined trends in the severity of the practice by measuring changes in the prevalence of flesh removal, infibulation and symbolic 'nicking' of the genitals...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225946/did-the-right-to-health-get-across-the-line-examining-the-united-nations-resolution-on-the-sustainable-development-goals
#8
REVIEW
Claire E Brolan, Vannarath Te, Nadia Floden, Peter S Hill, Lisa Forman
Since the new global health and development goal, Sustainable Development Goal (SDG) 3, and its nine targets and four means of implementation were introduced to the world through a United Nations (UN) General Assembly resolution in September 2015, right to health practitioners have queried whether this goal mirrors the content of the human right to health in international law. This study examines the text of the UN SDG resolution, Transforming our world: the 2030 Agenda for Sustainable Development, from a right to health minimalist and right to health maximalist analytic perspective...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29224570/mapping-the-evidence-on-pharmacological-interventions-for-non-affective-psychosis-in-humanitarian-non-specialised-settings-a-unhcr-clinical-guidance
#9
Giovanni Ostuzzi, Corrado Barbui, Charlotte Hanlon, Sudipto Chatterjee, Julian Eaton, Lynne Jones, Derrick Silove, Peter Ventevogel
BACKGROUND: Populations exposed to humanitarian emergencies are particularly vulnerable to mental health problems, including new onset, relapse and deterioration of psychotic disorders. Inadequate care for this group may lead to human rights abuses and even premature death. The WHO Mental Health Gap Action Programme Intervention Guide (mhGAP-IG), and its adaptation for humanitarian settings (mhGAP-HIG), provides guidance for management of mental health conditions by non-specialised healthcare professionals...
December 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29220365/a-novel-methodology-for-strengthening-human-rights-based-monitoring-in-public-health-family-planning-indicators-as-an-illustrative-example
#10
Sofia Gruskin, Laura Ferguson, Shubha Kumar, Alexandra Nicholson, Moazzam Ali, Rajat Khosla
OBJECTIVE: The last few years have seen a rise in the number of global and national initiatives that seek to incorporate human rights into public health practice. Nonetheless, a lack of clarity persists regarding the most appropriate indicators to monitor rights concerns in these efforts. The objective of this work was to develop a systematic methodology for use in determining the extent to which indicators commonly used in public health capture human rights concerns, using contraceptive services and programmes as a case study...
2017: PloS One
https://www.readbyqxmd.com/read/29216969/legal-issues-for-transgender-people-a-review-of-persistent-threats
#11
Jamison Green
Background The legal status of transgender (trans) people is in constant flux. Over the past 70 years, gradually increasing transgender visibility, national and global advocacy, and, more recently, widespread Internet access, communication, and broadening support from allies, have all contributed to successful campaigns that have improved transgender lives and legitimised transgender. Still, traumatic interactions with the legal system or policing agencies remain plentiful. This is a very general overview of the most common legal issues confronting trans people...
October 2017: Sexual Health
https://www.readbyqxmd.com/read/29216477/human-laterality-for-manipulation-and-gestural-communication-related-to-60-everyday-activities-impact-of-multiple-individual-related-factors
#12
Jacques Prieur, Stéphanie Barbu, Catherine Blois-Heulin
Literature on laterality emphasises the importance of implementing a comprehensive investigation of humans' and non-humans' laterality for both non-communication and communication functions. Adopting a global approach should enhance our understanding of the mechanistic drivers of human brain functional lateralisation and help to explore further the nature of the left-hemispheric systems for both functions. This study investigated human laterality for both functions by taking, for the first time, numerous behaviours and multiple potential influential factors into consideration...
November 11, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29214594/bridging-the-gap-between-health-and-social-care-for-rare-diseases-key-issues-and-innovative-solutions
#13
Raquel Castro, Juliette Senecat, Myriam de Chalendar, Ildikó Vajda, Dorica Dan, Béata Boncz
Bridging the gaps between health and social care for rare diseases is not only necessary but crucial to increase the life expectancy, quality of life and autonomy of people living with a rare disease, supporting them in the full realisation of their fundamental human rights.The complexity of rare diseases, their strong relation to disability and the current unmet social and daily life needs of people living with a rare disease must not be underestimated and require urgent attention from all stakeholders involved in care provision, from healthcare to social and community services...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29213302/a-comprehensive-review-of-hiv-sti-prevention-and-sexual-and-reproductive-health-services-among-sex-workers-in-conflict-affected-settings-call-for-an-evidence-and-rights-based-approach-in-the-humanitarian-response
#14
REVIEW
Alyssa Ferguson, Kate Shannon, Jennifer Butler, Shira M Goldenberg
Background: While the conditions in emergency humanitarian and conflict-affected settings often result in significant sex work economies, there is limited information on the social and structural conditions of sex work in these settings, and the impacts on HIV/STI prevention and access to sexual and reproductive health (SRH) services for sex workers. Our objective was to comprehensively review existing evidence on HIV/STI prevention and access to SRH services for sex workers in conflict-affected settings globally...
2017: Conflict and Health
https://www.readbyqxmd.com/read/29211299/endoplasmic-reticulum-stress-induced-lox-1-cd15-polymorphonuclear-myeloid-derived-suppressor-cells-in-hepatocellular-carcinoma
#15
Nan Jiang, Yan-Fang Xing, Bo Hu, Jian-Xin Tang, Hui-Min Dong, Yu-Mei He, Dan-Yun Ruan, Qing-Jian Ye, Jia-Rong Cai, Xiao-Kun Ma, Jie Chen, Xiu-Rong Cai, Ze-Xiao Lin, Xiang-Yuan Wu, Xing Li
AIM: A recent study indicated that Lectin-type oxidized LDL receptor-1 (LOX-1) was a distinct surface marker for human polymorphonuclears myeloid-derived suppressor cells (PMN-MDSC). The present study was aimed to investigate the existence LOX-1 PMN-MDSC in hepatocellular carcinoma (HCC) patients. METHODS: 127 HCC patients, 10 patients with mild active chronic hepatits B, 10 liver cirrhosis due to hepatitis B, 10 liver dysplastic node with hepatitis B and 50 health control were included...
December 6, 2017: Immunology
https://www.readbyqxmd.com/read/29207287/nursing-students-experiences-with-refugees-with-mental-health-problems-in-jordan-a-qualitative-content-analysis
#16
Camilla Dotevall, Elin Winberg, Kristina Rosengren
OBJECTIVES: The aim of this study was to describe Jordanian nursing students' experience of caring for refugees with mental health problems. BACKGROUND: According to refugees' experiences of crisis, a well-educated staff is needed to provide high quality of care due to mental health problems. Therefore, health professionals play an important role in creating an environment that promotes human rights regardless of ethnic origin. SETTINGS, PARTICIPANTS, METHOD: The study comprised eight interviews and was analysed using content analysis, a qualitative method that involves an inductive approach, to increase our understanding of nursing students' perspective and thoughts regarding caring for refugees with mental health problems...
November 28, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29206298/effects-of-poly-i-c-and-mf59-co-adjuvants-on-immunogenicity-and-efficacy-of-survivin-polypeptide-immunogen-against-melanoma
#17
Xiaoyu Jiang, Shanshan Guan, Yongbo Qiao, Xiao Li, Yan Xu, Lan Yang, Ziyu Kuai, Haihong Zhang, Yuhua Shi, Wei Kong, Yaming Shan, Hao Zhang
Malignant tumors pose a public health problem that jeopardizes human life and quality of living. At present, tumor vaccines in clinical research typically are aimed at stimulating the cellular immune response, while more effective vaccines should take into account the synergy between broad spectrum antibodies and high levels of cellular immunity. In this study, epitope peptides (68-81, 95-104, 80-88) of the tumor antigen survivin were chosen as immunogens and supplemented with poly(I:C) and/or MF59 adjuvant to evaluate the immune effects and anti-melanoma activities...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29205785/plant-polyphenols-stimulate-adhesion-to-intestinal-mucosa-and-induce-proteome-changes-in-the-probiotic-lactobacillus-acidophilus-ncfm
#18
Hasan Ufuk Celebioglu, Marta Delsoglio, Susanne Brix, Enrica Pessione, Birte Svensson
SCOPE: Plant phenolics, known to exert beneficial effects on human health, were supplemented to cultures of the probiotic bacterium Lactobacillus acidophilus NCFM (NCFM) to assess their effect on its adhesive capacity and the abundancy of individual proteins. METHODS AND RESULTS: The presence of resveratrol and ferulic acid during bacterial growth stimulated adhesion of NCFM to mucin and human intestinal HT-29 cells, while tannic acid improved adhesion only to HT-29 cells and caffeic acid had very modest effect overall...
December 4, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29205549/identification-and-characterization-of-antibodies-elicited-by-human-cystatin-c-fragment
#19
Izabela Behrendt, Martyna Prądzińska, Marta Spodzieja, Paulina Czaplewska, Aleksandra S Kołodziejczyk, Aneta Szymańska, Franciszek Kasprzykowski, Susanna L Lundström, Roman A Zubarev, Sylwia Rodziewicz-Motowidło
Amyloid formation is associated with a number of neurodegenerative diseases that affect the independence and quality of life of aging populations. One of rather atypical, occurring at a young age amyloidosis is hereditary cystatin C amyloid angiopathy (HCCAA) related to aggregation of L68Q variant of human cystatin C (hCC). Human cystatin C plays a very important role in many aspects of human health; however, its amyloidogenic properties manifested in HCCAA present a real, lethal threat to some populations and any work on factors that can affect possible influencing hCC aggregation is not to overestimate...
December 5, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29205215/symmetry-of-lower-limb-loading-in-healthy-adults-during-normal-and-abnormal-stance
#20
Jacek Stodółka, Małgorzata Sobera
PURPOSE: The purpose of the research was twofold: (1) to describe the normal asymmetry in lower limb loading during a normal stance and during a stance with visual and vestibular disturbance relating to the lower limb dominance, (2) to assess relations of loading of both lower limbs with body weight and height (BMI) and leg functional dominance. METHODS: The subjects of this study were 95 students. Settings of the two Kistler platforms were used to register the time series of the vertical component of the ground reaction force while the subject was standing (45 seconds) in a normal position and next with eyes covered with a band and head tilted back position with one leg placed on one platform and the other on the second platform...
2017: Acta of Bioengineering and Biomechanics
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