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Neurocognitive disorders

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https://www.readbyqxmd.com/read/29667531/is-tobacco-use-associated-with-neurocognitive-dysfunction-in-individuals-with-hiv
#1
Billy Tsima, Sarah Jane Ratcliffe, Robert Schnoll, Ian Frank, Dennis Larry Kolson, Robert Gross
INTRODUCTION: The prevalence of HIV-associated neurocognitive disorders continues to rise despite the widespread use of antiretroviral therapy. We aimed to define the risk of neurocognitive dysfunction among smokers relative to nonsmokers. METHODS: We conducted a retrospective cohort study including HIV-infected adults ages 21 to 65 years. The Mental Alternation Test (MAT) was the primary outcome. The odds of cognitive impairment were compared using random-effects logistic regression to adjust for potential confounders...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29660215/polygenic-risk-for-psychiatric-disorders-correlates-with-executive-function-in-typical-development
#2
Andrew J Schork, Timothy T Brown, Donald J Hagler, Wesley K Thompson, Chi-Hua Chen, Anders M Dale, Terry L Jernigan, Natacha Akshoomoff
Executive functions are a diverse and critical suite of cognitive abilities that are often disrupted in individuals with psychiatric disorders. Despite their moderate to high heritability, little is known about the molecular genetic factors that contribute to variability in executive function and how these factors may be related to those that predispose to psychiatric illness. We examined the relationship between polygenic risk scores built from large genome-wide association studies of psychiatric illness and executive functioning in typically developing children...
April 16, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29656802/impact-on-the-brain-of-the-inflammatory-response-to-surgery
#3
Sarah Saxena, Mervyn Maze
The brain is both the orchestrator as well as the target of the innate immune system's response to the aseptic trauma of surgery. When trauma-induced inflammation is not appropriately regulated persistent neuro-inflammation interferes with the synaptic plasticity that underlies the learning and memory aspects of cognition. The complications that ensue, include postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) at two poles of a constellation that is now termed perioperative neurocognitive disorders...
April 12, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29655375/association-between-traumatic-stress-load-psychopathology-and-cognition-in-the-philadelphia-neurodevelopmental-cohort
#4
Ran Barzilay, Monica E Calkins, Tyler M Moore, Daniel H Wolf, Theodore D Satterthwaite, J Cobb Scott, Jason D Jones, Tami D Benton, Ruben C Gur, Raquel E Gur
BACKGROUND: Traumatic stressors during childhood and adolescence are associated with psychopathology, mostly studied in the context of post-traumatic stress disorder (PTSD) and depression. We investigated broader associations of traumatic stress exposure with psychopathology and cognition in a youth community sample. METHODS: The Philadelphia Neurodevelopmental Cohort (N = 9498) is an investigation of clinical and neurobehavioral phenotypes in a diverse (56% Caucasian, 33% African American, 11% other) US youth community population (aged 8-21)...
April 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29652955/-neurodevelopmental-assessment-of-patients-with-congenital-hypothyroidism
#5
Alicia Núñez, Paula Bedregal, Carlos Becerra, Francisca Grob L
Congenital hypothyroidism (CH) is the most common cause of preventable cognitive disability worldwide. Generally, it is produced by an alteration in the embryogenesis of the thyroid gland or by an alteration in the synthesis of thyroid hormones, which determine that affected patients have low or absent thyroid hormone concentrations. The importance of this fact is that brain development during the first three years of life is highly dependent on thyroid hormones. Prior to the implementation of national neonatal screening programs around the world, 8 to 27% of children with CH had an IQ lower than 70...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29652529/neurocognitive-predictors-of-clinical-improvement-in-selective-serotonin-reuptake-inhibitor-treated-adolescents-with-major-depressive-disorder
#6
Fadi Maalouf, Rinad Bakhti, Hani Tamim, Safa Shehab, David Brent
OBJECTIVES: Numerous studies have suggested cognitive deficits as consistently associated with adolescent depression. No study to date, however, has assessed neurocognitive predictors of selective serotonin reuptake inhibitor (SSRI) treatment response in adolescents with depression. This study examined neurocognitive tasks at baseline as predictors of clinical improvement with SSRI treatment (fluoxetine) at week 6 and 12 in an adolescent population. METHODS: Adolescents with depression were recruited from a child and adolescent psychiatry outpatient clinic at a university medical center...
April 13, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29649712/sexual-abuse-but-not-posttraumatic-stress-disorder-is-associated-with-neurocognitive-deficits-in-south-african-traumatized-adolescents
#7
Sarah V Biedermann, Stefanie Meliss, Candice Simmons, Jani Nöthling, Sharain Suliman, Soraya Seedat
OBJECTIVES: Neurocognitive impairments are commonly observed in adults suffering from posttraumatic stress disorder (PTSD). The picture is less clear in adolescents. Childhood sexual abuse (CSA) may have an independent influence on neuropsychological test performance and provide partial explanatory power of the inconsistent findings. We hypothesized that adolescents with PTSD who have also suffered sexual abuse would have most pronounced deficits on neurocognitive testing. METHODS: In a cross-sectional design, 105 traumatized South African adolescents, of whom 52 fulfilled criteria of PTSD and 34 reported CSA, were studied...
April 9, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29644532/methamphetamine-induces-apoptosis-of-microglia-via-the-intrinsic-mitochondrial-dependent-pathway
#8
Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahajan
Methamphetamine (METH) is a drug of abuse, the acute and chronic use of which induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Our goals were to understand the impact of METH on microglial mitochondrial respiration and to determine whether METH induces the activation of the mitochondrial-dependent intrinsic apoptosis pathway in microglia. We assessed the expression of pro- apoptosis genes using qPCR of RNA extracted from a human microglial cell line (HTHU). We examined the apoptosis-inducing effects of METH on microglial cells using digital holographic microscopy (DHM) to quantify real-time apoptotic volume decrease (AVD) in microglia in a noninvasive manner...
April 11, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29643258/prevalence-of-poststroke-neurocognitive-disorders-using-national-institute-of-neurological-disorders-and-stroke-canadian-stroke-network-vascog-criteria-vascular-behavioral-and-cognitive-disorders-and-optimized-criteria-of-cognitive-deficit
#9
Mélanie Barbay, Hervé Taillia, Claudine Nédélec-Ciceri, Flavie Bompaire, Camille Bonnin, Jérôme Varvat, Françoise Grangette, Momar Diouf, Emmanuel Wiener, Jean-Louis Mas, Martine Roussel, Olivier Godefroy
BACKGROUND AND PURPOSE: The prevalence of poststroke neurocognitive disorder (NCD) has yet to be accurately determined. The primary objective of the present study was to optimize operationalization of the criterion for NCD by using an external validity criterion. METHODS: The GRECOG-VASC cohort (Groupe de Réflexion pour l'Évaluation Cognitive Vasculaire) of 404 stroke patients with cerebral infarct (91.3%) or hemorrhage (18.7%) was assessed 6 months poststroke and 1003 healthy controls, with the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network standardized battery...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29627704/bipolar-disorder-and-obsessive-compulsive-disorder-the-comorbidity-does-not-further-impair-the-neurocognitive-profile
#10
Renato de Filippis, Matteo Aloi, Antonella Bruni, Raffaele Gaetano, Cristina Segura-Garcia, Pasquale De Fazio
BACKGROUND: The comorbidity of bipolar disorder (BD) and obsessive-compulsive disorder (OCD) has been widely described. Several studies have investigated the cognitive profiles of BD and OCD patients, but studies that compare BD, BD-OCD, and OCD patients in neuropsychological domains do not exist. The purpose of this study was to compare set-shifting, decision making, and central coherence among BD, BD-OCD, and OCD patients. METHODS: A battery of neuropsychological tests was administered to 68 patients (22 BD, 26 BD-OCD, 20 OCD)...
March 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29627173/room-to-move-plasticity-in-early-auditory-information-processing-and-auditory-learning-in-schizophrenia-revealed-by-acute-pharmacological-challenge
#11
Neal R Swerdlow, Savita G Bhakta, Gregory A Light
Many patients with chronic psychotic disorders including schizophrenia (SZ) maintain meaningful levels of plasticity (i.e., capacity for change) within neurocognition-relevant brain mechanisms, as evidenced by gains in neurocognition and function after interventions such as targeted cognitive training. However, like many clinical features of these disorders, therapeutic responses in SZ are heterogeneous, and prospectively identifying treatment-sensitive individuals and individualized treatment modalities remains an unmet challenge...
April 4, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29622780/new-biomarkers-of-postoperative-neurocognitive-disorders
#12
Zhongcong Xie, Yuan Shen
No abstract text is available yet for this article.
April 5, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29621819/-icd-11-neurocognitive-disorders
#13
Frank Jessen, Lutz Frölich
The section 06 (Mental, Behavioural or Neurodevelopmental Disorders) of the current version Beta Draft (Mortality and Morbidity Statistics, 16.12.2017) of the ICD 11 (International Statistical Classification of Diseases and Related Health Problems) replaces the F0-section of the ICD-10. Several changes, particularly with regard to the classification of neurodegenerative disorders have been introduced. It can be considered a progress that the concept of "organic" syndromes has been dropped and that the section focusses on acquired conditions with cognition as the main area of symptoms...
March 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29621031/neurocognitive-function-after-cardiac-surgery-from-phenotypes-to-mechanisms
#14
Miles Berger, Niccolò Terrando, S Kendall Smith, Jeffrey N Browndyke, Mark F Newman, Joseph P Mathew
For half a century, it has been known that some patients experience neurocognitive dysfunction after cardiac surgery; however, defining its incidence, course, and causes remains challenging and controversial. Various terms have been used to describe neurocognitive dysfunction at different times after cardiac surgery, ranging from "postoperative delirium" to "postoperative cognitive dysfunction or decline." Delirium is a clinical diagnosis included in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)...
April 5, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29620405/neurocognitive-and-behavioral-predictors-of-social-problems-in-adhd-a-bayesian-framework
#15
Michael J Kofler, Sherelle L Harmon, Paula A Aduen, Taylor N Day, Kristin E Austin, Jamie A Spiegel, Lauren Irwin, Dustin E Sarver
OBJECTIVE: Social problems are a key area of functional impairment for children with attention deficit hyperactivity disorder (ADHD), and converging evidence points to executive dysfunction as a potential mechanism underlying ADHD-related social dysfunction. The evidence is mixed, however, with regard to which neurocognitive abilities account for these relations. METHOD: A well-characterized group of 117 children ages 8-13 (M = 10.45, SD = 1.53; 43 girls; 69.5% Caucasian/Non-Hispanic) with ADHD (n = 77) and without ADHD (n = 40) were administered multiple, counterbalanced tests of neurocognitive functioning and assessed for social skills via multi-informant reports...
March 2018: Neuropsychology
https://www.readbyqxmd.com/read/29620009/the-link-between-structural-connectivity-and-neurocognition-illustrated-by-focal-epilepsy
#16
Elise Roger, Laurent Petit, Marcela Perrone-Bertolotti, Anne-Sophie Job, Lorella Minotti, Philippe Kahane, Monica Baciu
Increasing attention is being paid to the assessment of white matter properties and its structural connectivity, both in healthy subjects and patients with cerebral lesions. Within this framework, new neurocognitive models based on hodological properties have been developed under a connectomic perspective in order to explain substrates and cognitive mechanisms related to cerebral functions such as language and memory. With regards to focal and drug-resistant epilepsy conceived as a network disorder, new insights in terms of structural connectivity have led to significant advances in epilepsy research, concerning fundamental research (neurocognitive mechanisms of plasticity) and clinical application (optimization of decision making for curative surgery)...
April 5, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29617061/the-relationship-of-internet-addiction-with-attention-deficit-hyperactivity-disorder-effects-of-anxiety-depression-and-self-esteem
#17
Özlem Kahraman, Esra Özdemir Demirci
AIM: Attention Deficit and Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood. Behavioral disinhibition, poor neurocognitive skills and immediate reward preference in childrenwith ADHD have been suggested as risk factors for internet addiction. In our study, we aimed to determine relationship between internet addiction with depression, anxiety, self-esteem in adolescents with ADHD and the features of internet use that predicts internet addiction...
April 4, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29615940/impact-of-cognitive-remediation-therapy-on-neurocognitive-processing-in-anorexia-nervosa
#18
Jenni Leppanen, James Adamson, Kate Tchanturia
Background: Anorexia nervosa (AN) is characterized by severe malnutrition as well as inefficiencies in neurocognitive functioning, which are believed to contribute to the maintenance of disordered eating. The aim of this study was to examine the impact of individual cognitive remediation therapy (CRT) on neurocognition in AN. Methods: A total of 145 adult women from an eating disorders inpatient program took part in the present study. All participants were given individual CRT in addition to treatment as usual...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29614390/can-neuropsychological-testing-facilitate-differential-diagnosis-between-at-risk-mental-state-arms-for-psychosis-and-adult-attention-deficit-hyperactivity-disorder-adhd
#19
Erich Studerus, Salvatore Corbisiero, Nadine Mazzariello, Sarah Ittig, Letizia Leanza, Laura Egloff, Katharina Beck, Ulrike Heitz, Christina Andreou, Rolf-Dieter Stieglitz, Anita Riecher-Rössler
BACKGROUND: Patients with an at-risk mental state (ARMS) for psychosis and patients with attention-deficit/hyperactivity disorder (ADHD) have many overlapping signs and symptoms and hence can be difficult to differentiate clinically. The aim of this study was to investigate whether the differential diagnosis between ARMS and adult ADHD could be improved by neuropsychological testing. METHODS: 168 ARMS patients, 123 adult ADHD patients and 109 healthy controls (HC) were recruited via specialized clinics of the University of Basel Psychiatric Hospital...
March 31, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29613944/neurocognitive-effects-of-repetitive-transcranial-magnetic-stimulation-with-a-2-coil-device-in-treatment-resistant-major-depressive-disorder
#20
Brian C Kavanaugh, Scott T Aaronson, Gregory N Clarke, Paul E Holtzheimer, Clark W Johnson, William M McDonald, M Bret Schneider, Linda L Carpenter
BACKGROUND: Neurocognitive dysfunction is an understudied and undertreated aspect of psychiatric research and treatment. There is emerging evidence to suggest that repetitive transcranial magnetic stimulation (rTMS) may possess neurocognition-enhancing capabilities. METHODS: This study examined the neurocognitive data from a randomized, double-blind, sham-controlled trial of an investigational 2-coil rTMS device in antidepressant treatment or treatment-intolerant major depressive disorder patients...
April 2, 2018: Journal of ECT
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