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https://www.readbyqxmd.com/read/29684757/microrna-144-suppresses-the-expression-of-cytokines-through-targeting-rankl-in-the-matured-immune-cells
#1
Rui-Dong Li, Cong-Huan Shen, Yi-Feng Tao, Xiao-Fei Zhang, Quan-Bao Zhang, Zhen-Yu Ma, Zheng-Xin Wang
To investigate whether the microRNA-144 (miR-144) had immune regulation effect on matured immune cells, we firstly used quantitative RT-PCR (qRT-PCR) to detect the expression changes of miR-144 between the matured and immature dendritic cells (DCs), macrophages, and the peripheral blood mononuclear cells (PBMCs). Then we went on inspecting the expression changes of TNF-α, IL-1β, IL-6 and IL-23 in the matured DCs treated with miR-144 mimics or inhibitors using qRT-PCR, and also performed western blot to test phosphorylation state of ERK, JNK, p38 and p65 in these cells...
April 20, 2018: Cytokine
https://www.readbyqxmd.com/read/29684666/systematic-review-of-preservation-solutions-for-allografts-for-liver-transplantation-based-on-a-network-meta-analysis
#2
REVIEW
Fengying Rao, Jian Yang, Cheng Gong, Rong Huang, Qi Wang, Jun Shen
AIMS: The aim of this work was to determine the best preservation solutions for allografts for liver transplantation by quantitative network meta-analysis. METHODS: Global electronic databases including PubMed, EMBASE, and Cochrane Library were searched for relevant randomized controlled trials. Seven pieces of parametric data were extracted from included studies for pooled estimation. A consistency model was used for direct and indirect comparisons. The cumulative probability P value was utilized to rank the solutions...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684562/bmt-following-non-myeloablative-treosulfan-conditioning-is-curative-in-a-murine-model-of-sickle-cell-disease
#3
Divya Devadasan, Chiao-Wang Sun, Erik R Westin, Li-Chen Wu, Kevin M Pawlik, Tim M Townes, Frederick D Goldman
Allogeneic hematopoietic stem cell transplantation (HSCT) can be curative for patients with sickle cell disease (SCD). However, morbidity associated with myeloablative conditioning and graft versus host disease has limited its utility. To this end, autologous HSCT for SCD using lentiviral gene-modified bone marrow (BM) or peripheral blood stem cells has been undertaken, though toxicities of fully ablative conditioning with busulfan and incomplete engraftment have been encountered. Treosulfan, a busulfan analog with a low extra-medullary toxicity profile, has been employed successfully as part of a myeloablative conditioning regimen in the allogeneic setting in SCD...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29684255/molecular-profiling-of-post-reperfusion-milieu-determines-acute-kidney-injury-after-liver-transplantation-a-prospective-study
#4
Carlo Pulitano, Phong Ho, Deborah Verran, Charbel Sandroussi, David Joseph, David G Bowen, Geoffrey W McCaughan, Michael Crawford, Nicholas Shackel
Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study is to investigate the potential relationship between post-reperfusion gene expression, serum mediators, and the onset of AKI after LT. Sixty-five consecutive patients undergoing LT were included in the study. Reverse transcription polymerase chain reaction (RT- PCR), was performed on liver biopsies. Gene expression of 23 genes involved in ischemia reperfusion injury (IRI) was evaluated...
April 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29684248/celiac-axis-extension-grafts-in-orthotopic-liver-transplantation
#5
J A Geha, N T Galvan, M Kueht, D Yoeli, J D Geha, A Rana, R T Cotton, C A O'Mahony, J A Goss
No abstract text is available yet for this article.
April 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29684001/one-hundred-and-fifteen-cases-of-pure-laparoscopic-living-donor-right-hepatectomy-at-a-single-center
#6
Kwang-Woong Lee, Suk Kyun Hong, Kyung-Suk Suh, Hyo-Sin Kim, Sung-Woo Ahn, Kyung Chul Yoon, Jeong-Moo Lee, Jae-Hyung Cho, Hyeyoung Kim, Nam-Joon Yi
BACKGROUND: The pure laparoscopic approach to donor hepatectomy is being taken more often. However, few centers perform pure laparoscopic donor right hepatectomy (PLDRH) because it requires a high level of surgical skill. Studies reporting initial outcomes of PLDRH may prompt further implementation of the technique and help reduce initial learning curves at other transplant centers. This study reports performance of PLDRH at a single center with extensive experience of adult living donor liver transplantation...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29684000/split-liver-transplantation-and-pediatric-waitlist-mortality-in-the-united-states-potential-for-improvement
#7
Emily R Perito, Garrett Roll, Jennifer L Dodge, Sue Rhee, John P Roberts
BACKGROUND: In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. METHODS: Using UNOS STAR data, we identified livers transplanted 2010-2015 that could potentially have been used for split transplant, based on strict criteria. Livers not suitable for pediatric patients or allocated to high-risk recipients were excluded...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683930/importance-of-18f-fdg-pet-ct-to-select-patients-with-nonresectable-colorectal-liver-metastases-for-liver-transplantation
#8
Harald Grut, Mona-Elisabeth Revheim, Pål-Dag Line, Svein Dueland
OBJECTIVE: The aim of this study was to evaluate fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT for the selection of patients with nonresectable colorectal liver metastases (NCLM) for liver transplantation (LT). In the secondary cancer study, we reported an improved 5-year overall survival in patients treated with LT for NCLM (56%) compared with chemotherapy (9%). However, many patients were rejected for LT owing to the detection of extrahepatic disease at preoperative imaging. PATIENTS AND METHODS: F-FDG PET/CT and contrast-enhanced computed tomography (ceCT) examinations before tentative LT for NCLM were assessed, and findings contraindicating LT were registered...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29683437/re-arterialized-rat-partial-liver-transplantation-with-an-in-vivo-vessel-oriented-70-hepatectomy
#9
Xuehai Chen, Rong Yu, Ziqiang Xu, Yan Zhang, Chengyang Liu, Bicheng Chen, Hao Jin
Split liver transplantation and living liver donor liver transplantation were developed in the clinic to utilize liver organs in a more efficient manner. To better understand the mechanism behind these surgical procedures, a rat partial liver transplantation (PLTx) model was established for relevant surgical studies. Because of the complexity of the rat PLTx model, a protocol with detailed descriptions is required. An article published previously reported a protocol in which ex vivo hepatectomy was used to achieve 50% rat PLTx...
April 8, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683220/medical-crowdfunding-for-organ-transplantation
#10
Wesley M Durand, Jillian L Peters, Adam E M Eltorai, Saisanjana Kalagara, Adena J Osband, Alan H Daniels
An increasing number of patients and families are utilizing online crowdfunding to support their medical expenses related to organ transplantation. The factors influencing the success of crowdfunding campaigns are poorly understood. Crowdfunding campaigns were abstracted from a popular crowdfunding website. Campaigns were included if they were actively accepting donations to fund medical expenses related to transplantation of selected organs. The primary outcome measure was total amount raised among successful campaigns receiving at least one donation...
April 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29682909/a-qualitative-signature-for-early-diagnosis-of-hepatocellular-carcinoma-based-on-relative-expression-orderings
#11
Lu Ao, Zimei Zhang, Qingzhou Guan, Yating Guo, You Guo, Jiahui Zhang, Xingwei Lv, Haiyan Huang, Huarong Zhang, Xianlong Wang, Zheng Guo
BACKGROUND & AIMS: Currently, using biopsy specimens to confirm suspicious liver lesions of early hepatocellular carcinoma (HCC) are not entirely reliable due to insufficient sampling amount and inaccurate sampling location. It is necessary to develop a signature to aid early HCC diagnosis using biopsy specimens even when the sampling location is inaccurate. METHODS: Based on the within-sample relative expression orderings of gene pairs, we identified a simple qualitative signature to distinguish both HCC and adjacent non-tumor tissues from cirrhosis tissues of non-HCC patients...
April 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29682248/current-challenges-of-liver-transplantation-in-iran
#12
Reza F Saidi, Seyed Mohammad Kazemaini, Reza Malekzadeh
Liver transplantation (LT) is a lifesaving procedure and the treatment of choice for patients suffering from end-stage liver disease (ESLD). There is increasing number of patients with ESLD in Iran. There is a need to expand and develop new centers to provide better access to LT for patients with ESLD in Iran. This review will address current and future challenges for LT in Iran.
January 2018: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29681874/alexithymia-in-gastroenterology-and-hepatology-a-systematic-review
#13
Danilo Carrozzino, Piero Porcelli
Background: Alexithymia is a multifaceted personality construct that represents a deficit in the cognitive processing of emotions and is currently understood to be related to a variety of medical and psychiatric conditions. The present review aims to investigate the relationship of alexithymia with gastrointestinal (GI) disorders as functional gastrointestinal disorders (FGID, as irritable bowel syndrome (IBS) and functional dyspepsia) and inflammatory bowel disease (IBD) [ulcerative colitis (UC) and Crohn's disease (CD)] and liver diseases as chronic hepatitis C (CHC), cirrhosis, and liver transplantation...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29681633/secondary-sclerosing-cholangitis-in-critically-ill-patients
#14
Carlos Alberto Peña-Pérez, Juan Alberto Díaz Ponce-Medrano
Primary sclerosing cholangitis (PSC) is a rare idiopathic condition with immunopathogenic mechanisms where there is chronic progressive destruction of the biliary tree. Secondary sclerosing cholangitis (SSC) is clinically comparable to PSC, but is caused by specific processes which directly damage the biliary tree; examples include recurrent pancreatitis, bile duct malignancy, congenital bile duct abnormalities. A new cause of SSC has been described during or following significant critical illness associated with severe respiratory insufficiency, vasopressor requirement, shock and sepsis...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29680846/association-of-time-under-immunosuppression-and-different-immunosuppressive-medication-on-periodontal-parameters-and-selected-bacteria-of-patients-after-solid-organ-transplantation
#15
G Schmalz, L Berisha, H Wendorff, F Widmer, A Marcinkowski, H Teschler, U Sommerwerck, R Haak, O Kollmar, D Ziebolz
BACKGROUND: Aim of this study was to investigate the association of the time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected periodontal pathogenic bacteria of immunosuppressed patients after solid organ transplantation (SOT). MATERIAL AND METHODS: 169 Patients after SOT (lung, liver or kidney) were included and divided into subgroups according their time under (0-1, 1-3, 3-6, 6-10 and >10 years) and form of immunosuppression (Tacrolimus, Cyclosporine, Mycophenolate, Glucocorticoids, Sirolimus and monotherapy vs...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29679437/preoperative-platelet-count-is-associated-with-increased-risk-of-posthepatectomy-grade-a-liver-failure-in-right-lobe-donors-for-liver-transplantation
#16
Kenji Yoshino, Kojiro Taura, Yoshinobu Ikeno, Yukihiro Okuda, Takahiro Nishio, Gen Yamamoto, Satoru Seo, Shintaro Yagi, Koichiro Hata, Toshimi Kaido, Hideaki Okajima, Shinji Uemoto
Living donor right hepatectomy (LDRH) is a common procedure in adult-to-adult living donor liver transplantation (LDLT), but is associated with a higher risk of posthepatectomy liver failure (PHLF) compared with left hepatectomy because of a smaller remnant. We identified risk factors for PHLF and other complications in LDRH, verified the appropriateness of the criteria, and explored the possibility of adjusting the minimum RLV based on individual risk. Between October 2005 and November 2017, 254 donors undergoing LDRH at Kyoto University Hospital were enrolled...
April 20, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29679376/-too-female-for-liver-transplantation
#17
Omobonike O Oloruntoba, Cynthia A Moylan
No abstract text is available yet for this article.
April 20, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29679347/pre-emptive-treatment-of-hcv-after-living-donor-liver-transplantation-with-direct-acting-antiviral-agents
#18
Jinmin Jung, Jae Hyun Kwon, Gi-Won Song, Eun-Young Tak, Vavara A Kirchner, Sung-Gyu Lee
BACKGROUND: Hepatitis C virus (HCV) universally recurs after liver transplantation (LT). Although the introduction of direct-acting antiviral agents (DAAs) has revolutionized the treatment of HCV infection, no optimal treatment for HCV recurrence after LT has been developed. METHODS: This study retrospectively evaluated the efficacy of DAAs as a pre-emptive treatment for recurrent HCV infection after living donor liver transplantation (LDLT). From January 2010 to December 2016, 70 patients received pegylated interferon (PegIFN) and 35 patients were treated with DAA-based regimens to treat recurrent HCV after LDLT...
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29678162/tacrolimus-induced-parkinsonism-in-a-patient-after-liver-transplantation-case-report
#19
Karin Gmitterová, Michal Minár, Miroslav Žigrai, Zuzana Košutzká, Alice Kušnírová, Peter Valkovič
BACKGROUND: Hepatic encephalopathy may manifest by a wide spectrum of neuropsychiatric symptoms, including cognitive impairment, seizures or extrapyramidal symptoms. The liver transplant can lead to improvement of the signs of encephalopathy but subsequent immunosuppressive treatment might possess pronounced neurotoxicity. CASE PRESENTATION: We present a case report of a patient with chronic liver disease who developed signs of Parkinsonism after an orthotopic liver transplant, with consecutive immunosuppressant treatment with tacrolimus...
April 20, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29677394/outflow-obstruction-after-liver-transplantation
#20
Miriam Cortes-Cerisuelo, Hector Vilca-Melendez, Nigel Heaton
No abstract text is available yet for this article.
May 2018: American Journal of Transplantation
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