Nicole Lerminiaux, Robyn Mitchell, Jessica Bartoszko, Ian Davis, Chelsey Ellis, Ken Fakharuddin, Susy S Hota, Kevin Katz, Pamela Kibsey, Jerome A Leis, Yves Longtin, Allison McGeer, Jessica Minion, Michael Mulvey, Sonja Musto, Ewa Rajda, Stephanie W Smith, Jocelyn A Srigley, Kathryn N Suh, Nisha Thampi, Jen Tomlinson, Titus Wong, Laura Mataseje
Carbapenems are considered last-resort antibiotics for the treatment of infections caused by multidrug-resistant Enterobacterales , but carbapenem resistance due to acquisition of carbapenemase genes is a growing threat that has been reported worldwide. Klebsiella pneumoniae carbapenemase ( bla KPC ) is the most common type of carbapenemase in Canada and elsewhere; it can hydrolyze penicillins, cephalosporins, aztreonam, and carbapenems and is frequently found on mobile plasmids in the Tn 4401 transposon. This means that alongside clonal expansion, bla KPC can disseminate through plasmid- and transposon-mediated horizontal gene transfer...
November 16, 2023: Antimicrobial Agents and Chemotherapy