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JOURNAL ARTICLE
Cristina M Fernandez, Mark B Krockenberger, Mathew S Crowther, Valentina S A Mella, Lachlan Wilmott, Damien P Higgins
In ruminants infected with Chlamydia pecorum, shorter lengths of coding tandem repeats (CTR) within two genes, the inclusion membrane protein (incA) and Type III secretor protein (ORF663), have been previously associated with pathogenic outcomes. In other chlamydial species, the presence of a chlamydial plasmid has been linked to heightened virulence, and the plasmid is not ubiquitous in C. pecorum across the koala's range. We therefore investigated these three markers: incA, ORF663 and C. pecorum plasmid, as potential indicators of virulence in two koala populations in New South Wales with differing expression of urogenital chlamydiosis; the Liverpool Plains and one across the Southern Highlands and South-west Sydney (SHSWS)...
November 15, 2023: Infection, Genetics and Evolution
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JOURNAL ARTICLE
Mayra L Estrella, Wassim Tarraf, Sayaka Kuwayama, Linda C Gallo, Benson Wu, María J Marquine, Krista M Perreira, Priscilla M Vasquez, Carmen R Isasi, Richard B Lipton, Josiemer Mattei, Hector M González, Martha L Daviglus, Melissa Lamar
INTRODUCTION: Few studies have examined the associations of psychosocial factors with cognitive change in Hispanics/Latinos. METHODS: Data from the Hispanic Community Health Study/Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL INCA) and Sociocultural studies were used (n = 2,155; ages ≥45 years). Psychosocial exposures included intrapersonal (ethnic identity, optimism, purpose in life), interpersonal (family cohesion, familism, social networks, social support), and social factors (ethnic discrimination, loneliness, subjective social status)...
October 28, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#23
JOURNAL ARTICLE
Paola C Mujica, Víctor Martinez
The Chilean Terrier is a known breed in Chile that has not been genetically assessed despite its distinctive color patterns, agility, and hardiness across the diversity of climates encountered within the Chilean landscape. The population structure and its relatedness with other breeds, as well as the actual origin of the breed, remain unknown. We estimated several population parameters using samples from individuals representing the distribution of the Chilean Terrier across the country. By utilizing the Illumina HD canine genotyping array, we computed the effective population size (Ne ), individual inbreeding, and relatedness to evaluate the genetic diversity of the breed...
October 1, 2023: Animal Genetics
#24
JOURNAL ARTICLE
Kevin A González, Wassim Tarraf, Ariana M Stickel, Sonya Kaur, Christian Agudelo, Susan Redline, Linda C Gallo, Carmen R Isasi, Jianwen Cai, Martha L Daviglus, Fernando D Testai, Charles DeCarli, Hector M González, Alberto R Ramos
INTRODUCTION: Sleep duration has been associated with dementia and stroke. Few studies have evaluated sleep pattern-related outcomes of brain disease in diverse Hispanics/Latinos. METHODS: The SOL-INCA (Study of Latinos-Investigation of Neurocognitive Aging) magnetic resonance imaging (MRI) study recruited diverse Hispanics/Latinos (35-85 years) who underwent neuroimaging. The main exposure was self-reported sleep duration. Our main outcomes were total and regional brain volumes...
September 29, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#25
JOURNAL ARTICLE
Muhammad Usman Qamar, Hasan Ejaz, Mashkoor Mohsin, Linda Hadjadj, Aylin Karadeniz, Jean-Marc Rolain, Zikria Saleem, Seydina M Diene
Background: To determine the prevalence of antimicrobial-resistant genes in carbapenem-resistant Escherichia coli (CRECO). Methods: A total of 290 carbapenem-resistant bacteria were collected from tertiary care hospitals in Lahore (Pakistan). These isolates were confirmed by VITEK 2 and matrix-assisted laser desorption/ionization time of flight. The minimum inhibitory concentration was performed by VITEK 2. Sequence typing, resistant gene identification, DNA hybridization and replicate typing were also performed...
September 1, 2023: Future Microbiology
#26
JOURNAL ARTICLE
J Y Blay, S Piperno-Neumann, S Watson, A Dufresne, T Valentin, F Duffaud, M Toulmonde, A Italiano, F Bertucci, C Tlemsani, N Firmin, E Bompas, C Perrin, M Ropars, E Saada-Bouzid, P Dubray-Longeras, A Hervieu, C Lebbe, J Gantzer, L Chaigneau, F Fiorenza, M Rios, N Isambert, P Soibinet, P Boudou-Roquette, B Verret, G Ferron, T Ryckewaert, L Lebellec, M Brahmi, F Gouin, P Meeus, G Vaz, F Le Loarer, M Karanian, G De Pinieux, F Ducimetiere, C Chemin, M Morelle, A Le Cesne, N Penel
EPITHELIOID HEMANGIOENDOTHELIOMA: A NATIONWIDE STUDY: Epithelioid hemangioendothelioma (EHE) is an ultrarare sarcoma whose natural history and treatment is not well defined. We report on the presentation and outcome of 267 patients with EHE in the NETSARC+ network since 2010 in France. PATIENTS AND METHODS: NETSARC (netsarc.org) is a network of 26 reference sarcoma centres with specialised multidisciplinary tumour boards (MDTB), funded by the French National Cancer Institute (NCI), Institut National du Cancer (INCA)...
October 2023: European Journal of Cancer
#27
JOURNAL ARTICLE
Eduardo Paulino, Andreia Cristina de Melo
OBJECTIVE: To analyze the outcomes of a cohort of patients with high-risk histologies of endometrial cancer (EC) treated at Instituto Nacional de Câncer (National Cancer Institute, INCA, in Portuguese), in Brazil. MATERIALS AND METHODS: We reviewed the medical records of patients with high-risk histologies of EC in any stage registered at INCA between 2010 and 2016 to perform a clinical and demographic descriptive analysis and to evaluate the outcomes in terms of recurrence and survival...
July 2023: Revista Brasileira de Ginecologia e Obstetrícia
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JOURNAL ARTICLE
Chao Wu, Michael Guarnieri, Wei Xiong
13 C metabolic flux analysis is a powerful tool for metabolism characterization in metabolic engineering and synthetic biology. However, the widespread adoption of this tool is hindered by limited software availability and computational efficiency. Currently, the most widely accepted 13 C-flux tools, such as INCA and 13CFLUX2, are developed in a closed-source environment. While several open-source packages or software are available, they are either computationally inefficient or only suitable for flux estimation at isotopic steady state...
August 10, 2023: ACS Synthetic Biology
#29
JOURNAL ARTICLE
X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease.
Thiago P Leal, Shilpa C Rao, Jennifer N French-Kwawu, Mateus H Gouveia, Victor Borda, Sara Bandres-Ciga, Miguel Inca-Martinez, Emily A Mason, Andrea R V R Horimoto, Douglas P Loesch, Elif I Sarihan, Mario R Cornejo-Olivas, Luis E Torres, Pilar E Mazzetti-Soler, Carlos Cosentino, Elison H Sarapura-Castro, Andrea Rivera-Valdivia, Angel C Medina, Elena M Dieguez, Víctor E Raggio, Andrés Lescano, Vitor Tumas, Vanderci Borges, Henrique B Ferraz, Carlos R Rieder, Artur Schumacher Schuh, Bruno L Santos-Lobato, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio, Francisco Lopera, Sonia Moreno, Pedro Chana-Cuevas, William Fernandez, Gonzalo Arboleda, Humberto Arboleda, Carlos E Arboleda Bustos, Dora Yearout, Maria F Lima-Costa, Eduardo Tarazona-Santos, Cyrus P Zabetian, Timothy A Thornton, Timothy D O'Connor, Ignacio F Mata
BACKGROUND: Sex differences in Parkinson's disease (PD) risk are well-known. However, the role of sex chromosomes in the development and progression of PD is still unclear. OBJECTIVE: The objective of this study was to perform the first X-chromosome-wide association study for PD risk in a Latin American cohort. METHODS: We used data from three admixed cohorts: (1) Latin American Research consortium on the Genetics of Parkinson's Disease (n = 1504) as discover cohort, and (2) Latino cohort from International Parkinson Disease Genomics Consortium (n = 155) and (3) Bambui Aging cohort (n = 1442) as replication cohorts...
July 20, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
#30
JOURNAL ARTICLE
Hiroaki Kubota, Tomohiro Nakayama, Tsukasa Ariyoshi, Satomi Uehara, Yumi Uchitani, Sachio Tsuchida, Hiroyuki Nishiyama, Ichiro Morioka, Tsugumichi Koshinaga, Akiko Kusabuka, Naoki Nakatsubo, Takuya Yamagishi, Yuri Tabuchi, Rumi Okuno, Kai Kobayashi, Morika Mitobe, Keiko Yokoyama, Takayuki Shinkai, Jun Suzuki, Kenji Sadamasu
Phytobacter diazotrophicus is an Enterobacterales species that was originally identified as a plant growth-promoting, Gram-negative bacterium. Recently, this species has been recognized as relevant to opportunistic human and nosocomial infections in clinical settings. Its frequent misidentification as other Enterobacterales species from clinical examination occasionally causes a delay in the identification of nosocomial outbreaks. Here, we report the emergence of New Delhi metallo-β-lactamase (NDM)-producing P...
July 14, 2023: MSphere
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JOURNAL ARTICLE
Isabel N Carramaschi, Margareth M de C Queiroz, Fabio Faria da Mota, Viviane Zahner
The present study presents phenotypic and molecular characterization of a multidrug-resistant strain of Escherichia coli (Lemef26), belonging to sequence type ST9499 carrying a blaNDM-1 carbapenem resistance gene. The bacterium was isolated from a specimen of Musca domestica, collected in proximity to a hospital in Rio de Janeiro City, Brazil. The strain was identified as E. coli by matrix-assisted laser desorption-ionization time of flight mass spectrometry (Maldi-TOF-MS) and via genotypic analysis (Whole-Genome Sequencing-WGS), followed by phylogenetic analysis, antibiotic resistance profiling (using phenotypic and genotypic methods) and virulence genotyping...
July 12, 2023: Current Microbiology
#32
JOURNAL ARTICLE
Patrick Skilleter, David Nelson, Ian C Dodd
Since soil compaction of potato fields delays shoot emergence and decreases total yield, the causes and effects of this compaction need to be better understood. In a controlled environment trial with young (before tuber initiation) plants, roots of cv. Inca Bella (a phureja group cultivar) were more sensitive to increased soil resistance (3.0 MPa) than cv. Maris Piper (a tuberosum group cultivar). Such variation was hypothesized to cause yield differences in two field trials, in which compaction treatments were applied after tuber planting...
2023: Frontiers in Plant Science
#33
JOURNAL ARTICLE
Ankur Rao, Sharmi Naha, Amrita Bhattacharjee, Pinaki Chattopadhyay, Shanta Dutta, Sulagna Basu
OBJECTIVE: Presence and dissemination of plasmid-mediated AmpCs genes (pAmpCs) have made bacteria cephalosporin-resistant; assessment of their prevalence and diversity is essential. Co-existence of pAmpCs with New Delhi metallo-β-lactamase (blaNDM ) has facilitated their spread; NDM interferes with correct pAmpC phenotypic identification. METHODS: Assessment of pAmpCs in different species and sequence types (STs), co-transmission with blaNDM and phenotypic detection were analysed among Klebsiella pneumoniae (n=256) and Escherichia coli (n=92) isolated from septicaemic neonates over thirteen years...
June 13, 2023: Journal of Global Antimicrobial Resistance
#34
JOURNAL ARTICLE
Robin Greinert, Alexander Zipprich, Markus Casper, Matthias Christian Reichert, Frank Lammert, Cristina Ripoll
BACKGROUND: Patients with cirrhosis who carry NOD2 mutations are susceptible to bacterial infections. The aim was to evaluate the association of NOD2 mutations with hepatic and systemic hemodynamics in cirrhosis. PATIENTS AND METHODS: This is a secondary analysis of a prospectively collected database in the context of the screening for the INCA trial (EudraCT 2013-001626-26). This cross-sectional study compared hemodynamic findings according to NOD2 status in 215 patients...
June 13, 2023: Digestive and Liver Disease
#35
JOURNAL ARTICLE
Wim L Cuypers, Pieter Meysman, François-Xavier Weill, Rene S Hendriksen, Getenet Beyene, John Wain, Satheesh Nair, Marie A Chattaway, Blanca M Perez-Sepulveda, Pieter-Jan Ceyssens, Tessa de Block, Winnie W Y Lee, Maria Pardos de la Gandara, Christian Kornschober, Jacob Moran-Gilad, Kees T Veldman, Martin Cormican, Mia Torpdahl, Patricia I Fields, Tomáš Černý, Liselotte Hardy, Bieke Tack, Kate C Mellor, Nicholas Thomson, Gordon Dougan, Stijn Deborggraeve, Jan Jacobs, Kris Laukens, Sandra Van Puyvelde
Antimicrobial resistant Salmonella enterica serovar Concord (S. Concord) is known to cause severe gastrointestinal and bloodstream infections in patients from Ethiopia and Ethiopian adoptees, and occasional records exist of S. Concord linked to other countries. The evolution and geographical distribution of S. Concord remained unclear. Here, we provide a genomic overview of the population structure and antimicrobial resistance (AMR) of S. Concord by analysing genomes from 284 historical and contemporary isolates obtained between 1944 and 2022 across the globe...
June 14, 2023: Nature Communications
#36
JOURNAL ARTICLE
Nancy Yaneth Flórez-Delgado, Elizabeth Noelia Ubillus, Blanca Perez-Sepulveda, Eyda Lizeth Ospina-Ríos, Ana Karina Carrascal-Camacho, Iliana C Chamorro-Tobar, Lucy Angeline Montaño, Yan Li, Silvana Zapata-Bedoya, Jay C D Hinton, José Miguel Villarreal, Magdalena Wiesner
Background. Salmonella enterica subsp. enterica serovar Typhimurium ( S . Typhimurium) has been linked to outbreaks of foodborne gastroenteritis disease, and the emergence of antimicrobial-resistant clones. In Colombia, laboratory surveillance of Salmonella spp. between 1997-2018 revealed that S . Typhimurium was the most ubiquitous serovar (27.6 % of all Salmonella isolates), with increasing levels of resistance to several families of antibiotics. Hypothesis. Resistant isolates of S . Typhimurium recovered from human clinical, food and swine samples carry class 1 integrons that are linked to antimicrobial resistance genes...
June 2023: Journal of Medical Microbiology
#37
JOURNAL ARTICLE
Sandip Patil, Xiaowen Chen, Shaowei Dong, Huirong Mai, Bruno Silvester Lopes, Sixi Liu, Feiqiu Wen
INTRODUCTION: The emergence of multidrug-resistant Pseudomonas aeruginosa poses a global threat, but the distribution and resistance profiling are unclear, especially in young children. Infections due to P. aeruginosa are common, associated with high mortality, and increasingly β-lactam drug resistant. METHODS: We studied the molecular epidemiology and antibiotic resistance mechanisms in 294 clinicalisolates of P. aeruginosa from a pediatric hospital in China...
2023: Frontiers in Cellular and Infection Microbiology
#38
JOURNAL ARTICLE
Xiaoshuang Feng, David C Muller, Hana Zahed, Karine Alcala, Florence Guida, Karl Smith-Byrne, Jian-Min Yuan, Woon-Puay Koh, Renwei Wang, Roger L Milne, Julie K Bassett, Arnulf Langhammer, Kristian Hveem, Victoria L Stevens, Ying Wang, Mikael Johansson, Anne Tjønneland, Rosario Tumino, Mahdi Sheikh, Mattias Johansson, Hilary A Robbins
BACKGROUND: To evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they can improve prediction of prognosis. METHODS: We measured up to 1159 proteins in blood samples from 708 participants in 6 cohorts. Samples were collected within 3 years prior to lung cancer diagnosis. We used Cox proportional hazards models to identify proteins associated with overall mortality after lung cancer diagnosis. To evaluate model performance, we used a round-robin approach in which models were fit in 5 cohorts and evaluated in the 6th cohort...
June 2023: EBioMedicine
#39
JOURNAL ARTICLE
Konstantina Gartzonika, Lida Politi, Angeliki Mavroidi, Andreas G Tsantes, Nicholas Spanakis, Efthalia Priavali, Georgia Vrioni, Athanasios Tsakris
NDM-type metallo-β-lactamase (MBL)-producing Enterobacterales remain uncommon in the European region, especially among species other than Klebsiella pneumoniae and Escherichia coli. The aim of this study was to describe epidemiological and molecular characteristics of a widespread NDM-1-producing Enterobacter cloacae complex outbreak in Greece. Over a 6-year period (March 2016-March 2022), a retrospective study was conducted in a tertiary care Greek hospital. Ninety single-patient carbapenem-non-susceptible E...
May 6, 2023: International Journal of Antimicrobial Agents
#40
JOURNAL ARTICLE
Sirirak Supa-Amornkul, Rattanaporn Intuy, Wuthiwat Ruangchai, Soraya Chaturongakul, Prasit Palittapongarnpim
S. 4,[5],12:i:-, a monophasic variant of S. enterica serovar Typhimurium, is an important multidrug resistant serovar. Strains of colistin-resistant S. 4,[5],12:i:- have been reported in several countries with patients occasionally had recent histories of travels to Southeast Asia. In the study herein, we investigated the genomes of S. 4,[5],12:i:- carrying mobile colistin resistance (mcr) gene in Thailand. Three isolates of mcr-3.1 carrying S. 4,[5],12:i:- in Thailand were sequenced by both Illumina and Oxford Nanopore platforms and we analyzed the sequences together with the whole genome sequences of other mcr-3 carrying S...
May 1, 2023: Scientific Reports
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