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https://www.readbyqxmd.com/read/29128409/breast-cancer-related-perceptions-and-practices-of-health-professionals-working-in-brazil-s-network-of-primary-care-units
#1
Benjamin D Hallowell, Douglas M Puricelli Perin, Eduardo J Simoes, Diana C Paez, Diana C Parra, Ross C Brownson, Mona Saraiya
In 2004 the Brazilian National Cancer Institute (INCA) established breast cancer screening guidelines for women in Brazil: annual clinical breast exam for women age 40-49 and biennial mammogram for women age 50-69. Healthcare provider's adherence to these guidelines is currently unknown. The objective of this study is to describe the perceptions and practices related to breast cancer screening among physicians, nurses, and health unit coordinators working in the network of primary healthcare units (HCUs) in Brazil...
November 8, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29091756/enteroendocrine-l-cells-sense-lps-after-gut-barrier-injury-to-enhance-glp-1-secretion
#2
Lorène J Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naig Le Guern, Jiri Plesnik, Charles Thomas, Thibaut Bourgeois, Cornelis H C Dejong, Matthijs Kox, Inca H R Hundscheid, Naim Akhtar Khan, Stéphane Mandard, Valérie Deckert, Peter Pickkers, Daniel J Drucker, Laurent Lagrost, Jacques Grober
Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that plasma GLP-1 levels are rapidly increased by lipopolysaccharide (LPS) administration in mice via a Toll-like receptor 4 (TLR4)-dependent mechanism. Experimental manipulation of gut barrier integrity after dextran sodium sulfate treatment, or via ischemia/reperfusion experiments in mice, triggered a rapid rise in circulating GLP-1...
October 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/29081367/first-case-of-new-delhi-metallo-%C3%AE-lactamase-in-klebsiella-pneumoniae-from-ecuador-an-update-for-south-america
#3
Daniel Romero-Alvarez, Jorge Reyes, Viviana Quezada, Carolina Satán, Nelson Cevallos, Sofía Barrera, Gabriel Trueba, Luis E Escobar, José E Villacís
OBJECTIVES: To describe a clinical case of Klebsiella pneumoniae harboring New Delhi metallo-β-lactamase (NDM) plasmid in Ecuador and to present a map of reports of NDM isolates in South America. METHODS: We used the Modified Hodge Test, Carbapenem Inactivation Method, the synergy with imipenem-EDTA disk method, and Rapidec Carba NP for identification of antibiotic resistance mechanisms. The presence of resistant genes was explored with a conjugation assay, and molecular confirmation of NDM with PCR and DNA sequencing...
October 25, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29038283/ctx-m-15-producing-shewanella-sp-clinical-isolate-expressing-oxa-535-a-chromosome-encoded-oxa-48-variant-putative-progenitor-of-the-plasmid-encoded-oxa-436
#4
Agnès B Jousset, Laura Dabos, Rémy A Bonnin, Delphine Girlich, Anaïs Potron, Nicolas Cabanel, Laurent Dortet, Philippe Glaser, Thierry Naas
Shewanella spp. constitute a reservoir of antibiotic resistance determinants. In a bile sample, we have identified three Extended Spectrum β-lactamase (ESBL)-producing bacteria (Escherichia coli, Klebsiella pneumoniae and Shewanella sp. JAB-1) isolated from a child suffering from cholangitis. Our objectives were to characterize the genome and the resistome of the first ESBL-producing isolate of the genus Shewanella and determine whether plasmidic exchange occurred between the three-bacterial species. Bacterial isolates were characterized using MALDI-TOF, standard biochemical tools and antimicrobial susceptibility testing...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28992919/genotypic-and-epidemiologic-characterization-of-extended-spectrum-cephalosporin-resistant-salmonella-enterica-from-us-beef-feedlots
#5
D F Mollenkopf, D A Mathys, D A Dargatz, M M Erdman, G G Habing, J B Daniels, T E Wittum
In the US, nontyphoidal Salmonellae are a common foodborne zoonotic pathogen causing gastroenteritis. Invasive Salmonella infections caused by extended-spectrum cephalosporin resistant (ESCR) phenotypes are more likely to result in treatment failure and adverse health outcomes, especially in severe pediatric Salmonella infections where the extended-spectrum β-lactams are the therapy of choice. To examine the genetic and epidemiologic characteristics of ESCR Salmonellae which may enter the food chain, we characterized 44 ceftiofur-resistant Salmonella isolates from the National Animal Health Monitoring System (NAHMS) 2011 beef cattle feedlot health and management study...
October 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28987805/emergence-of-carbapenem-resistant-escherichia-coli-isolates-producing-blandm-and-blaoxa-48-like-carried-on-inca-c-and-incl-m-plasmids-at-two-iranian-university-hospitals
#6
Hamid Solgi, Christian G Giske, Farzad Badmasti, Shadi Aghamohammad, Seyed Asghar Havaei, Shahram Sabeti, Kamyar Mostafavizadeh, Fereshteh Shahcheraghi
The emergence of carbapenem resistance among Escherichia coli is a serious threat to public health. The objective of this study was to investigate resistance genes and clonality of carbapenem resistant E. coli in Iran. Between February 2015 and July 2016, a total of 32 non-duplicate E. coli isolates that were ertapenem resistant or intermediate (R/I-ETP) were collected from patient clinical or surveillance cultures (rectal swabs) at two university hospitals. Resistance genes were identified by PCR and sequencing...
October 4, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28919197/imported-poultry-meat-as-a-source-of-extended-spectrum-cephalosporin-resistant-cmy-2-producing-salmonella-heidelberg-and-s-minnesota-in-european-union-2014-2015
#7
Joana Campos, Joana Mourão, Leonor Silveira, Margarida Saraiva, Cristina Belo Correia, Ana Paula Maçãs, Luísa Peixe, Patrícia Antunes
Extended-spectrum cephalosporin (ESC)-resistant Salmonella has been described at low level in EU, nevertheless the increasing importation of poultry meat could be an important source of epidemic strains carrying ESC-resistant genes. We evaluated ESC resistance and characterized genetic platforms as well as the clonal relatedness of Salmonella isolates from poultry meat products imported into Portugal. All Salmonella isolates recovered from samples of fresh meat destined to be imported into the EU in the scope of Portuguese official border control between 2014 and 2015 were studied...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28919196/inca-c-plasmids-conferring-high-azithromycin-resistance-in-vibrio-cholera
#8
Ruibai Wang, Haican Liu, Xiuqin Zhao, Jie Li, Kanglin Wan
Azithromycin (AZM) is a clinically important antibiotic to Vibrio cholerae especially for inhibiting colonization of V. cholerae in intestine and the treatment of severe cholera in children and pregnant women. One IncA/C plasmid was isolated from both of the high MIC AZM resistant V cholerae strains of the two mainly pathogenic serogroups, O1 and O139. In the 172 predicted ORFs, 16 genes were related to antibiotic resistance in which 5 were well-defined genes associated with macrolide resistance. The 5 macrolide resistant genes disturbed in two clusters, mphR-mrx-mph(K) and mel-mph2, flanking by insertion sequence (IS) and involving two kinds of mechanisms...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28878309/identification-of-orit-and-a-recombination-hot-spot-in-the-inca-c-plasmid-backbone
#9
Anna Hegyi, Mónika Szabó, Ferenc Olasz, János Kiss
Dissemination of multiresistance has been accelerating among pathogenic bacteria in recent decades. The broad host-range conjugative plasmids of the IncA/C family are effective vehicles of resistance determinants in Gram-negative bacteria. Although more than 150 family members have been sequenced to date, their conjugation system and other functions encoded by the conserved plasmid backbone have been poorly characterized. The key cis-acting locus, the origin of transfer (oriT), has not yet been unambiguously identified...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859446/oxa-427-a-new-plasmid-borne-carbapenem-hydrolysing-class-d-%C3%AE-lactamase-in-enterobacteriaceae
#10
Pierre Bogaerts, Thierry Naas, Veroniek Saegeman, Remy A Bonnin, Annette Schuermans, Stéphanie Evrard, Warda Bouchahrouf, Thomas Jove, Didier Tande, Xavier de Bolle, Te-Din Huang, Laurent Dortet, Youri Glupczynski
Objectives: To describe a novel plasmid-borne class D carbapenemase (CHDL) named OXA-427 identified in several Enterobacteriaceae clinical isolates from nine patients in one Belgian hospital. Methods: OXA-427-producing isolates were analysed by an electrochemical imipenem hydrolysis method (BYG Carba test), Carba NP test, conventional phenotypic assays and by molecular methods (PCR, whole sequencing of the OXA-427-encoding plasmid and cloning). The antimicrobial resistance profile of OXA-427 was analysed by expression of the cloned gene in Escherichia coli DH10B and J53...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28801276/transferability-of-antimicrobial-resistance-from-multidrug-resistant-escherichia-coli-isolated-from-cattle-in-the-usa-to-e-coli-and-salmonella-newport-recipients
#11
T L Poole, T R Callaway, K N Norman, H M Scott, G H Loneragan, S A Ison, R C Beier, D M Harhay, B Norby, D J Nisbet
OBJECTIVES: This study aimed to evaluate conjugative transfer of cephalosporin resistance among 100 strains of multidrug-resistant Escherichia coli (MDRE) to Salmonella enterica serotype Newport and E. coli DH5α recipients. METHODS: Phenotypic and genotypic profiles were determined for MDRE as well as for Salmonella Newport (trSN) and E. coli DH5α (trDH) transconjugants. RESULTS: Of 95 MDRE donor isolates, 26 (27%) and 27 (28%) transferred resistance to trSN and trDH recipients, respectively...
August 8, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28728058/high-prevalence-of-esbls-in-retail-chicken-meat-despite-reduced-use-of-antimicrobials-in-chicken-production-france
#12
Tiago Casella, Mara Correa Lelles Nogueira, Estelle Saras, Marisa Haenni, Jean-Yves Madec
Extended-spectrum cephalosporins (ESCs) are critically important antibiotics for humans and their use in animals poses a potential threat for public health. Chicken represents an increasing part of the human diet and has also been regarded as a source of ESC-resistant Enterobacteriaceae because of the worldwide off-label use of ceftiofur, a broad-spectrum cephalosporin. Thus, numerous studies pointed out chicken as a reservoir of ESBL/pAmpC genes, plasmids and/or clones at risk for humans. In France, late 2011, strong political pressure led to a drastic reduction of ceftiofur use and all other antibiotics in chicken production...
July 10, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28711559/outbreak-of-colistin-resistant-carbapenemase-producing-klebsiella-pneumoniae-in-tunisia
#13
Wejdène Mansour, Marisa Haenni, Estelle Saras, Raoudha Grami, Yosra Mani, Anis Ben Haj Khalifa, Souhail El Atrouss, Mohamed Kheder, Mohamed Fekih Hassen, Noureddine Boujâafar, Olfa Bouallegue, Jean-Yves Madec
OBJECTIVES: Mechanisms of colistin and carbapenem resistance among a collection of Klebsiella pneumoniae isolates recovered in a university hospital in Tunisia were studied. METHODS: In vitro antimicrobial susceptibility testing, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blotting and PCR-based replicon typing (PBRT) were performed. Extended-spectrum β-lactamases (ESBLs), carbapenemases, AmpC-type enzymes and mgrB genes were detected by PCR and sequencing...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28696228/characterization-of-the-complete-nucleotide-sequences-of-inca-c2-plasmids-carrying-in809-like-integrons-from-enterobacteriaceae-isolates-of-wildlife-origin
#14
Costas C Papagiannitsis, Iva Kutilova, Matej Medvecky, Jaroslav Hrabak, Monika Dolejska
A total of 18 Enterobacteriaceae (17 from gulls and 1 from a clinical sample) collected from Australia, carrying IncA/C plasmids with the IMP-encoding In809-like integrons, were studied. Seven plasmids, being representatives of different origins, plasmid sizes, replicon combinations, and resistance genes, were completely sequenced. Plasmid pEc158, identified in a clinical Escherichia coli ST752 isolate, showed extensive similarity to type 2 IncA/C2 plasmids. pEc158 carried none of the blaCMY-2-like region or ARI-B and ARI-A regions, while it contained a hybrid transposon structure...
September 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28689921/the-novel-mef-c-mph-g-macrolide-resistance-genes-are-conveyed-in-the-environment-on-various-vectors
#15
Yuta Sugimoto, Satoru Suzuki, Lisa Nonaka, Chanchai Boonla, Nop Sukpanyatham, Hsin-Yiu Chou, Jer-Horng Wu
BACKGROUND: The novel tandem genes mef(C) and mph(G) have been reported in marine bacteria in Japan. This paper aimed to characterise the extent of environmental distribution of mef(C) and mph(G) as well as their dissemination and persistence in aquatic bacterial communities. METHODS: Erythromycin-resistant bacteria were isolated from Japan, Taiwan and Thailand aquaculture sites. The mef(C)-mph(G) genes were detected by PCR. The size of mobile genetic elements conveying mef(C) and mph(G) was examined by Southern blotting...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28689895/plasmid-mediated-transfer-of-ctx-m-55-extended-spectrum-beta-lactamase-among-different-strains-of-salmonella-and-shigella-spp-in-the-republic-of-korea
#16
Jin Seok Kim, Soojin Kim, Jungsun Park, Eunkyung Shin, Young-Sun Yun, Deog-Yong Lee, Hyo-Sun Kwak, Won Keun Seong, Gyung Tae Chung, Junyoung Kim
We screened 10 CTX-M-55-producing Shigella and Salmonella isolates from a national surveillance in Korea. The blaCTX-M-55 was located on the IncI1 (n=5), IncA/C (n=4) and IncZ (n=1) plasmids, downstream of ISEcp1, IS26-ISEcp1 and ISEcp1-IS5 sequences, respectively. These results indicate that CTX-M-55 has disseminated to other bacteria by lateral plasmid transfer.
March 30, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28644010/atomic-layer-deposition-of-an-indium-gallium-oxide-thin-film-for-thin-film-transistor-applications
#17
Jiazhen Sheng, Eun Jung Park, Bonggeun Shong, Jin-Seong Park
Indium gallium oxide (IGO) thin films were deposited via atomic layer deposition (ALD) using [1,1,1-trimethyl-N-(trimethylsilyl)silanaminato]indium (InCA-1) and trimethylgallium (TMGa) as indium and gallium precursors, respectively, and hydrogen peroxide as the reactant. To clearly understand the mechanism of multicomponent ALD growth of oxide semiconductor materials, several variations in the precursor-reactant deposition cycles were evaluated. Gallium could be doped into the oxide film at 200 °C when accompanied by an InCA-1 pulse, and no growth of gallium oxide was observed without the simultaneous deposition of indium oxide...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28619778/in-patients-with-severe-uncontrolled-asthma-does-knowledge-of-adherence-and-inhaler-technique-using-electronic-monitoring-improve-clinical-decision-making-a-protocol-for-a-randomised-controlled-trial
#18
Matshediso C Mokoka, Lorna Lombard, Elaine M MacHale, Joanne Walsh, Breda Cushen, Imran Sulaiman, Damien Mc Carthy, Fiona Boland, Frank Doyle, Eoin Hunt, Desmond M Murphy, John Faul, Marcus Butler, Kathy Hetherington, J Mark FitzGerald, Job Fm van Boven, Liam G Heaney, Richard B Reilly, Richard W Costello
INTRODUCTION: Many patients with asthma remain poorly controlled despite the use of inhaled corticosteroids and long-acting beta agonists. Poor control may arise from inadequate adherence, incorrect inhaler technique or because the condition is refractory. Without having an objective assessment of adherence, clinicians may inadvertently add extra medication instead of addressing adherence. This study aims to assess if incorporating objectively recorded adherence from the Inhaler Compliance Assessment (INCA) device and lung function into clinical decision making provides more cost-effective prescribing and improves outcomes...
June 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28619146/dynamics-of-cmy-2-producing-e-coli-in-a-broiler-parent-flock
#19
Anita Dame-Korevaar, Egil A J Fischer, Arjan Stegeman, Dik Mevius, Alieda van Essen-Zandbergen, Francisca Velkers, Jeanet van der Goot
Extended-spectrum β-lactamase and plasmid mediated AmpC β-lactamase (ESBL/pAmpC) producing bacteria are resistant to Extended Spectrum Cephalosporins (ESC), and are present in all levels of the broiler production chain. We determined the prevalence, concentration, and persistence of ESBL/pAmpC-Escherichia coli in a broiler parent flock during the rearing and laying period. One-day old chickens were housed in four separate pens. Until week 33 no antibiotics or coccidiostatics were used. During rearing 57 chickens in each pen (n=228), and in the laying period two groups of 33 chickens were individually sampled (n=66)...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28611464/relict-high-andean-ecosystems-challenge-our-concepts-of-naturalness-and-human-impact
#20
Steven P Sylvester, Felix Heitkamp, Mitsy D P V Sylvester, Hermann F Jungkunst, Harrie J M Sipman, Johanna M Toivonen, Carlos A Gonzales Inca, Juan C Ospina, Michael Kessler
What would current ecosystems be like without the impact of mankind? This question, which is critical for ecosystem management, has long remained unanswered due to a lack of present-day data from truly undisturbed ecosystems. Using mountaineering techniques, we accessed pristine relict ecosystems in the Peruvian Andes to provide this baseline data and compared it with the surrounding accessible and disturbed landscape. We show that natural ecosystems and human impact in the high Andes are radically different from preconceived ideas...
June 13, 2017: Scientific Reports
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