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IncA/C

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https://www.readbyqxmd.com/read/28419869/allodemic-distribution-of-plasmids-co-harbouring-blactx-m-15-aac-6-ib-cr-qnrb-in-klebsiella-pneumoniae-is-the-main-source-of-extended-spectrum-%C3%AE-lactamases-in-uruguay-s-paediatric-hospital
#1
V Garcia-Fulgueiras, L Araujo, I Bado, N F Cordeiro, M I Mota, G Laguna, G Algorta, R Vignoli
OBJECTIVES: This study aimed to describe the characteristics of clinical isolates of extended-spectrum β-lactamase (ESBL)-producing enterobacteria (EPE) in Uruguay's paediatric hospital. METHODS: ESBLs, qnr alleles and aac(6')-Ib-cr were sought and characterised in EPE isolated between March 2010 and March 2012. Transfer of resistance determinants was assessed by conjugation. Incompatibility (Inc) groups, plasmid toxin-antitoxin systems (TAS) and plasmid size were determined in transconjugants...
April 15, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28398524/networking-for-ovarian-rare-tumors-a-significant-breakthrough-improving-disease-management
#2
N Chiannilkulchai, P Pautier, C Genestie, A S Bats, M C Vacher-Lavenu, M Devouassoux-Shisheboran, I Treilleux, A Floquet, S Croce, G Ferron, E Mery, C Pomel, F Penault-Llorca, C Lefeuvre-Plesse, S Henno, E Leblanc, A S Lemaire, G Averous, J E Kurtz, I Ray-Coquard
Background: Rare ovarian tumors represent >20% of all ovarian cancers. Given the rarity of these tumors, natural history, prognostic factors are not clearly identified. The extreme variability of patients (age, histological subtypes, stage) induces multiple and complex therapeutic strategies. Methods: Since 2011, a national network with a dedicated system for referral, up to 22 regional and three national reference centers (RC) has been supported by the French National Cancer Institute (INCa)...
April 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28355215/salmonella-genomic-island-1-sgi1-reshapes-the-mating-apparatus-of-incc-conjugative-plasmids-to-promote-self-propagation
#3
Nicolas Carraro, Romain Durand, Nicolas Rivard, Charley Anquetil, Catherine Barrette, Malika Humbert, Vincent Burrus
IncC conjugative plasmids and Salmonella genomic island 1 (SGI1) and relatives are frequently associated with multidrug resistance of clinical isolates of pathogenic Enterobacteriaceae. SGI1 is specifically mobilized in trans by IncA and IncC plasmids (commonly referred to as A/C plasmids) following its excision from the chromosome, an event triggered by the transcriptional activator complex AcaCD encoded by these helper plasmids. Although SGI1 is not self-transmissible, it carries three genes, traNS, traHS and traGS, coding for distant homologs of the predicted mating pore subunits TraNC, TraHC and TraGC, respectively, encoded by A/C plasmids...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28350567/watchful-waiting-versus-surgery-of-mildly-symptomatic-or-asymptomatic-inguinal-hernia-in-men-aged-50-years-and-older-a-randomized-controlled-trial
#4
Barry de Goede, Arthur R Wijsmuller, Gabrielle H van Ramshorst, Bob J van Kempen, Wim C J Hop, Pieter J Klitsie, Marc R Scheltinga, Jeroen de Haan, Walter J B Mastboom, Erwin van der Harst, Maarten P Simons, Gert-Jan Kleinrensink, Johannes Jeekel, Johan F Lange
OBJECTIVE: To compare if watchful waiting is noninferior to elective repair in men aged 50 years and older with mildly symptomatic or asymptomatic inguinal hernia. BACKGROUND: The role of watchful waiting in older male patients with mildly symptomatic or asymptomatic inguinal hernia is still not well-established. METHODS: In this noninferiority trial, we randomly assigned men aged 50 years and older with mildly symptomatic or asymptomatic inguinal hernia to either elective inguinal hernia repair or watchful waiting...
March 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28276133/plasmid-mediated-resistance-to-cephalosporins-and-quinolones-in-escherichia-coli-from-american-crows-in-the-usa
#5
Ivana Jamborova, Monika Dolejska, Ludek Zurek, Andrea K Townsend, Anne B Clark, Julie C Ellis, Ivo Papousek, Alois Cizek, Ivan Literak
American crow (Corvus brachyrhynchos) faeces were tested for Escherichia coli with plasmid-mediated quinolone resistance (PMQR), extended-spectrum beta-lactamases (ESBL) and AmpC beta-lactamases. A total of 590 faecal samples were collected at four roosting sites in the USA and cultivated on selective media. Pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) were performed to assess clonality. Transferability of resistance genes was studied using conjugation and transformation bioassays...
March 9, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28239454/transcriptional-analysis-of-blandm-1-and-copy-number-alteration-under-carbapenem-stress
#6
Deepjyoti Paul, Amitabha Bhattacharjee, Dibyojyoti Bhattacharjee, Debadatta Dhar, Anand Prakash Maurya, Atanu Chakravarty
BACKGROUND: New Delhi metallo beta-lactamase is known to compromise carbapenem therapy and leading to treatment failure. However, their response to carbapenem stress is not clearly known. Here, we have investigated the transcriptional response of blaNDM-1 and plasmid copy number alteration under carbapenem exposure. METHODS: Three blaNDM-1 harboring plasmids representing three incompatibility types (IncFIC, IncA/C and IncK) were inoculated in LB broth with and without imipenem, meropenem and ertapenem...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28183122/-i-ctenodontina-i-enderlein-1914-diptera-asilidae-asilinae-new-combinations-synonyms-new-species-and-new-records-for-argentina
#7
Rodrigo Vieira, José Manuel Ayala Landa, José Albertino Rafael
Ctenodontina Enderlein is reported for the first time in Argentina. A new species, C. sagta sp. nov. (Argentina, Salta) is described. New combination is Ctenodontina baleta (Walker), comb. nov. with two synonimies: Pachychoeta caracasae Martin syn. nov. and Pachychoeta inca Martin syn. nov. The male and female terminalia of C. baleta (Walker). comb. nov. is illustrated and described for the first time and a key to species is presented.
January 6, 2017: Zootaxa
https://www.readbyqxmd.com/read/28125687/high-heterogeneity-of-escherichia-coli-sequence-types-harbouring-esbl-ampc-genes-on-inci1-plasmids-in-the-colombian-poultry-chain
#8
Luis Ricardo Castellanos, Pilar Donado-Godoy, Maribel León, Viviana Clavijo, Alejandra Arevalo, Johan F Bernal, Arjen J Timmerman, Dik J Mevius, Jaap A Wagenaar, Joost Hordijk
BACKGROUND: Escherichia coli producing ESBL/AmpC enzymes are unwanted in animal production chains as they may pose a risk to human and animal health. Molecular characterization of plasmids and strains carrying genes that encode these enzymes is essential to understand their local and global spread. OBJECTIVES: To investigate the diversity of genes, plasmids and strains in ESBL/AmpC-producing E. coli from the Colombian poultry chain isolated within the Colombian Integrated Program for Antimicrobial Resistance Surveillance (Coipars)...
2017: PloS One
https://www.readbyqxmd.com/read/28092307/the-prosit-bio-cohort-a-prospective-observational-study-of-patients-with-inflammatory-bowel-disease-treated-with-infliximab-biosimilar
#9
Gionata Fiorino, Natalia Manetti, Alessandro Armuzzi, Ambrogio Orlando, Angela Variola, Stefanos Bonovas, Fabrizio Bossa, Giovanni Maconi, Renata DʼIncà, Paolo Lionetti, Laura Cantoro, Walter Fries, Maria L Annunziata, Francesco Costa, Maria M Terpin, Livia Biancone, Claudio C Cortelezzi, Arnaldo Amato, Sandro Ardizzone, Silvio Danese, Luisa Guidi, Giulia Rizzuto, Arianna Massella, Angelo Andriulli, Alessandro Massari, Greta Lorenzon, Silvia Ghione, Anna Kohn, Agostino Ventra, Vito Annese
BACKGROUND: Few data are available on the safety and efficacy of infliximab biosimilar CT-P13 in patients with ulcerative colitis and Crohn's disease. METHODS: A prospective, multicenter, cohort study using a structured database. RESULTS: Consecutive patients (313 Crohn's disease and 234 ulcerative colitis) were enrolled from 31 referral centers; 311 patients were naive to anti-tumor necrosis factor alpha, 139 had a previous exposure to biologics, and the remaining 97 were switched to CT-P13 after a mean of 18 ± 14 infusions of infliximab...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27993422/emergence-of-sequence-type-11-klebsiella-pneumoniae-coproducing-ndm-1-and-vim-1-metallo-%C3%AE-lactamases-in-a-greek-hospital
#10
C C Papagiannitsis, E Malli, Z Florou, S Sarrou, J Hrabak, K Mantzarlis, E Zakynthinos, E Petinaki
Sequence type 11 Klebsiella pneumoniae, coproducing NDM-1 and VIM-1 metallo-β-lactamases, were isolated in a Greek hospital. blaNDM-1 was part of a Tn125 derivative, located on an ~90-kb plasmid similar to the NDM-1-encoding plasmid pB-3002cz. blaVIM-1 was located in an In-e541-like integron, carried on a multireplicon (IncA/C and IncR) plasmid of ~180kb.
March 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27960372/flexible-and-high-performance-amorphous-indium-zinc-oxide-thin-film-transistor-using-low-temperature-atomic-layer-deposition
#11
Jiazhen Sheng, Hwan-Jae Lee, Saeroonter Oh, Jin-Seong Park
Amorphous indium zinc oxide (IZO) thin films were deposited at different temperatures, by atomic layer deposition (ALD) using [1,1,1-trimethyl-N-(trimethylsilyl)silanaminato]indium (INCA-1) as the indium precursor, diethlzinc (DEZ) as the zinc precursor, and hydrogen peroxide (H2O2) as the reactant. The ALD process of IZO deposition was carried by repeated supercycles, including one cycle of indium oxide (In2O3) and one cycle of zinc oxide (ZnO). The IZO growth rate deviates from the sum of the respective In2O3 and ZnO growth rates at ALD growth temperatures of 150, 175, and 200 °C...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27872077/identification-of-inca-c-plasmid-replication-and-maintenance-genes-and-development-of-a-plasmid-multilocus-sequence-typing-scheme
#12
Steven J Hancock, Minh-Duy Phan, Kate M Peters, Brian M Forde, Teik Min Chong, Wai-Fong Yin, Kok-Gan Chan, David L Paterson, Timothy R Walsh, Scott A Beatson, Mark A Schembri
Plasmids of incompatibility group A/C (IncA/C) are becoming increasingly prevalent within pathogenic Enterobacteriaceae They are associated with the dissemination of multiple clinically relevant resistance genes, including blaCMY and blaNDM Current typing methods for IncA/C plasmids offer limited resolution. In this study, we present the complete sequence of a blaNDM-1-positive IncA/C plasmid, pMS6198A, isolated from a multidrug-resistant uropathogenic Escherichia coli strain. Hypersaturated transposon mutagenesis, coupled with transposon-directed insertion site sequencing (TraDIS), was employed to identify conserved genetic elements required for replication and maintenance of pMS6198A...
February 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27828730/characterization-of-resistance-genes-and-plasmids-from-outbreaks-and-illness-clusters-caused-by-salmonella-resistant-to-ceftriaxone-in-the-united-states-2011-2012
#13
Jason P Folster, Julian E Grass, Amelia Bicknese, Julia Taylor, Cindy R Friedman, Jean M Whichard
Salmonella is an important cause of foodborne illness; however, quickly identifying the source of these infections can be difficult, and source identification is a crucial step in preventing additional illnesses. Although most infections are self-limited, invasive salmonellosis may require antimicrobial treatment. Ceftriaxone, an extended-spectrum cephalosporin, is commonly used for treatment of salmonellosis. Previous studies have identified a correlation between the food animal/retail meat source of ceftriaxone-resistant Salmonella and the type of resistance gene and plasmid it carries...
March 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27798828/a-study-on-the-electrical-properties-of-atomic-layer-deposition-grown-inox-on-flexible-substrates-with-respect-to-n2o-plasma-treatment-and-the-associated-thin-film-transistor-behavior-under-repetitive-mechanical-stress
#14
Jiazhen Sheng, Jozeph Park, Dong-Won Choi, Junhyung Lim, Jin-Seong Park
Indium oxide (InOx) films were deposited at low processing temperature (150 °C) by atomic layer deposition (ALD) using [1,1,1-trimethyl-N-(trimethylsilyl)silanaminato]indium (InCA-1) as the metal precursor and hydrogen peroxide (H2O2) as the oxidant. As-deposited InOx exhibits a metallic conductor-like behavior owing to a relatively high free-carrier concentration. In order to control the electron density in InOx layers, N2O plasma treatment was carried out on the film surface. The exposure time to N2O plasma was varied (600-2400 s) to evaluate its effect on the electrical properties of InOx...
November 16, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27727307/determination-and-analysis-of-the-putative-acacd-responsive-promoters-of-salmonella-genomic-island-1
#15
Gábor Murányi, Mónika Szabó, Ferenc Olasz, János Kiss
The integrative genomic island SGI1 and its variants confer multidrug resistance in numerous Salmonella enterica serovariants and several Proteus mirabilis and Acinetobacter strains. SGI1 is mobilized by the IncA/C family plasmids. The island exploits not only the conjugation apparatus of the plasmid, but also utilizes the plasmid-encoded master regulator AcaCD to induce the excision and formation of its transfer-competent form, which is a key step in the horizontal transfer of SGI1. Triggering of SGI1 excision occurs via the AcaCD-dependent activation of xis gene expression...
2016: PloS One
https://www.readbyqxmd.com/read/27667823/ndm-producing-enterobacteriaceae-in-a-chinese-hospital-2014-2015-identification-of-ndm-producing-citrobacterwerkmanii-and-acquisition-of-blandm-1-carrying-plasmid-in-vivo-in-a-clinical-escherichia-coli-isolate
#16
Jingna An, Ling Guo, Lin Zhou, Yanning Ma, Yanping Luo, Chuanmin Tao, Jiyong Yang
New Delhi metallo-β-lactamase (NDM)-producing Enterobacteriaceae (NPE) shows prevalence in China. Little is known about the mechanisms related to the spread of NPE. Recently, a total of 51 non-duplicated NPE isolates were collected from a tertiary-care hospital in China and analysed for genetic relatedness by PFGE, antimicrobial susceptibility by Etest and sequence type by multilocus sequence typing. S1-PFGE and Southern blot analysis or PCR amplification were used for plasmid profiling. Between 2014 and 2015, 22 Escherichia coli, 10 Klebsiella pneumoniae, 9 Enterobacter cloacae, 2 Enterobacter aerogenes, 3 Providencia rettgeri, 1 Klebsiella oxytoca, 1 Proteus mirabilis, 1 Citrobacter freundii, 1 Citrobacterwerkmanii and 1 Raoultella planticola were identified as NPE...
November 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27627862/exploring-imperial-expansion-using-an-isotopic-analysis-of-paleodietary-and-paleomobility-indicators-in-chachapoyas-peru
#17
J Marla Toyne, Warren B Church, Jose Luis Coronado Tello, Ricardo Morales Gamarra
OBJECTIVES: Inca imperial strategies of political and territorial expansion varied across conquered regions depending on local ecology and cultural resistance, and Chachapoya peoples in Peru's forested northeastern Andes were renowned for their rebellions against the invaders. The cliff tombs of Los Pinchudos (AD 1470-1535) present opportunities to use stable isotopes to: (1) explore dietary and mobility patterns from a mortuary community interred at a site attributed to the poorly-known Chachapoya culture during the period of Inca domination, and (2) explore the origins of the individuals as either local or foreign (Inca)...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27620651/destabilization-of-inca-and-incc-plasmids-by-sgi1-and-sgi2-type-salmonella-genomic-islands
#18
Christopher J Harmer, Mohammad Hamidian, Stephanie J Ambrose, Ruth M Hall
Both the Salmonella genomic islands (SGI) and the conjugative IncC plasmids are known to contribute substantially to the acquisition of resistance to multiple antibiotics, and plasmids in the A/C group are known to mobilize the Salmonella genomic island SGI1, which also carries multiple antibiotic resistance genes. Plasmid pRMH760 (IncC; A/C2) was shown to mobilize SGI1 variants SGI1-I, SGI1-F, SGI1-K and SGI2 from Salmonella enterica to Escherichia coli where it was integrated at the preferred location, at the end of the trmE (thdF) gene...
September 13, 2016: Plasmid
https://www.readbyqxmd.com/read/27620201/conservation-of-extrusion-as-an-exit-mechanism-for-chlamydia
#19
LETTER
Meghan Zuck, Ashley Sherrid, Robert Suchland, Tisha Ellis, Kevin Hybiske
Chlamydiae exit via membrane-encased extrusion or through lysis of the host cell. Extrusions are novel, pathogen-containing structures that confer infectious advantages to Chlamydia, and are hypothesized to promote cell-to-cell spread, dissemination to distant tissues and facilitate immune evasion. The extrusion phenomenon has been characterized for several Chlamydia trachomatis serovars, but a thorough investigation of extrusion for additional clinically relevant C. trachomatis strains and Chlamydia species has yet to be performed...
October 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27600047/characterization-of-two-multidrug-resistant-inca-c-plasmids-from-the-1960s-by-using-the-minion-sequencer-device
#20
Mónika Szabó, Tibor Nagy, Tímea Wilk, Tibor Farkas, Anna Hegyi, Ferenc Olasz, János Kiss
Two A/C incompatibility group (IncA/C family) plasmids from the 1960s have been sequenced and classified into the A/C2 type 1 group. R16a and IP40a contain novel antibiotic resistance islands and a complete GIsul2 genomic island not previously found in the family. In the 173.1-kb R16a, the 29.9-kb antibiotic resistance island (ARI) is located in a unique backbone position not utilized by ARIs. ARIR16a consists of Tn1, Tn6020, and Tn6333, harboring the resistance genes blaTEM-1D and aphA1b and a mer module, respectively; a truncated Tn5393 copy; and a gene cluster with unknown function...
November 2016: Antimicrobial Agents and Chemotherapy
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