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https://www.readbyqxmd.com/read/29768625/detection-of-blandm-1-in-stenotrophomonas-maltophilia-isolated-from-brazilian-soil
#1
João Pedro Rueda Furlan, André Pitondo-Silva, Eliana Guedes Stehling
This study reports the presence of the blaNDM-1 gene in an isolate of Stenotrophomonas maltophilia obtained from a Brazilian soil, inside an IncA/C plasmid with ~ 45 Kb. To the best of our knowledge, this is the second report in the world and the first in Brazil of NDM-producing bacterium isolated from soil.
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29661868/spread-of-clonally-related-escherichia-coli-harboring-an-inca-c-1-plasmid-encoding-imp-8-and-its-recruitment-into-an-unrelated-mcr-1-containing-isolate
#2
Alan Elena, Daniela Cejas, Francisco Magariños, Virginia Jewtuchowicz, Andrea Facente, Gabriel Gutkind, José Di Conza, Marcela Radice
Ten IMP-8-producing Escherichia coli isolates were recovered from the surveillance cultures of a neonatal intensive care unit, of which eight were clonally related. A 168.2-kb- bla IMP-8 plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13. This plasmid was detected in all isolates, even in those no clonally related. One unrelated isolate was also resistant to colistin and positive for mcr-1. This marker was located in a 62.7-kb-IncI2 plasmid, which was also fully sequenced...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29620958/sequence-analysis-of-inca-c-and-inci1-plasmids-isolated-from-multidrug-resistant-salmonella-newport-using-single-molecule-real-time-sequencing
#3
Guojie Cao, Marc Allard, Maria Hoffmann, Tim Muruvanda, Yan Luo, Justin Payne, Kevin Meng, Shaohua Zhao, Patrick McDermott, Eric Brown, Jianghong Meng
Multidrug-resistant (MDR) plasmids play an important role in disseminating antimicrobial resistance genes. To elucidate the antimicrobial resistance gene compositions in A/C incompatibility complex (IncA/C) plasmids carried by animal-derived MDR Salmonella Newport, and to investigate the spread mechanism of IncA/C plasmids, this study characterizes the complete nucleotide sequences of IncA/C plasmids by comparative analysis. Complete nucleotide sequencing of plasmids and chromosomes of six MDR Salmonella Newport strains was performed using PacBio RSII...
April 5, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29609544/detection-of-ctx-m-15-harboring-escherichia-coli-isolated-from-wild-birds-in-tunisia
#4
Houssem Ben Yahia, Rym Ben Sallem, Ghassan Tayh, Naouel Klibi, Insaf Ben Amor, Haythem Gharsa, Abdellatif Boudabbous, Karim Ben Slama
BACKGROUND: The spreading of antibiotic resistant bacteria is becoming nowadays an alarming threat to human and animal health. There is increasing evidence showing that wild birds could significantly contribute to the transmission and spreading of drug-resistant bacteria. However, data for antimicrobial resistance in wild birds remain scarce, especially throughout Africa. The aims of this investigation were to analyze the prevalence of ESBL-producing E. coli in faecal samples of wild birds in Tunisia and to characterize the recovered isolates...
April 2, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29605531/high-prevalence-of-ceftriaxone-resistance-among-invasive-salmonella-enterica-serotype-choleraesuis-isolates-in-thailand-the-emergence-and-increase-of-ctx-m-55-in-ciprofloxacin-resistant-s-choleraesuis-isolates
#5
Sirirat Luk-In, Tanittha Chatsuwan, Chaiwat Pulsrikarn, Aroon Bangtrakulnonth, Ubolrat Rirerm, Wanla Kulwichit
S. Choleraesuis is a highly invasive zoonotic pathogen that causes a serious systemic infection in humans. The emergence and increase of resistance to ceftriaxone and ciprofloxacin among S. Choleraesuis has become a serious therapeutic problem. The present study demonstrated high frequency of antimicrobial resistance in Salmonella Choleraesuis among 414 nontyphoidal Salmonella isolates from bacteremic patients in Thailand. High rates of ceftriaxone (58.3%) and ciprofloxacin (19.6%) resistances were observed in S...
March 23, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29549790/impact-of-co-carriage-of-inca-c-plasmids-with-additional-plasmids-on-the-transfer-of-antimicrobial-resistance-in-salmonella-enterica-isolates
#6
Jing Han, Sean J Pendleton, Joanna Deck, Ruby Singh, Jeffrey Gilbert, Timothy J Johnson, Yasser M Sanad, Rajesh Nayak, Steven L Foley
BACKGROUND: Antimicrobial resistance in Salmonella enterica is often plasmid encoded. A key resistance plasmid group is the incompatibility group (Inc) A/C plasmids that often carry multiple resistance determinants. Previous studies showed that IncA/C plasmids were often co-located with other plasmids. The current study was undertaken to evaluate the impact of plasmid co-carriage on antimicrobial resistance and plasmid transfer. METHODS: A total of 1267 Salmonella isolates, representing multiple serotypes and sources were previously subjected to susceptibility testing and 251 isolates with resistance to at least 5 antimicrobial agents were identified for further study...
January 31, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29535977/feasibility-of-a-conditional-knockout-system-for-chlamydia-based-on-crispr-interference
#7
Scot P Ouellette
Chlamydia is an obligate intracellular bacterium and, as such, has significantly reduced its genome size and content. Although recent advances have allowed for transformation of C. trachomatis with an exogenous plasmid, genetic manipulation of Chlamydia remains challenging. In particular, the ability to create conditional knockouts has not been developed. This is particularly important given the likelihood that most genes within the small genome of Chlamydia may be essential. Here, I describe the feasibility of using CRISPR interference (CRISPRi) based on the catalytically inactive Cas9 variant (dCas9) of Staphylococcus aureus to inducibly, and reversibly, repress gene expression in C...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29526748/detection-of-qnrvc6-within-a-new-genetic-context-in-a-ndm-1-producing-citrobacter-freundii-clinical-isolate-from-uruguay
#8
Inés Bado, Romina Papa Ezdra, Nicolás Cordeiro, Matilde Outeda, Leticia Caiata, Virginia García-Fulgueiras, Verónica Seija, Rafael Vignoli
OBJECTIVES: The objective of the present study was to characterise the mechanisms underlying quinolone and oxyimino-cephalosporin resistance in a Citrobacter freundii clinical isolate obtained from the ICU in Uruguay's University Hospital. METHODS: Citrobacter freundii strain CF638 was isolated from a urine culture. Identification and susceptibility testing were performed using the VITEK® 2 system, and MIC determination and disc diffusion assay, respectively. Resistance genes and mobile genetic elements were identified, by PCR and sequencing...
March 8, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29486211/compatibility-and-entry-exclusion-of-inca-and-incc-plasmids-revisited-inca-and-incc-plasmids-are-compatible
#9
Stephanie J Ambrose, Christopher J Harmer, Ruth M Hall
In an early study, IncA and IncC plasmids that were reported to be compatible were grouped as the "A-C complex" based on similarities and on strong entry exclusion. However, recently, the term IncA/C has been used frequently to describe plasmids belonging to both of these two groups. Granted that the supporting data was not included in the original reports and that the consensus iteron sequences have since been shown to be essentially identical, we have addressed the question again. The original IncA plasmid, RA1, and the IncC plasmid pRMH760, were introduced into the same cell by transformation, and were found to be maintained stably for over 100 generations in the absence of selection for either plasmid, i...
February 24, 2018: Plasmid
https://www.readbyqxmd.com/read/29463531/complete-sequence-of-the-inca-c-1-plasmid-pcf587-carrying-bla-per-2-from-citrobacter-freundii
#10
Melina Ruggiero, Delphine Girlich, Laura Dabos, Pablo Power, Thierry Naas, Gabriel Gutkind
The bla PER-2 -harboring plasmid pCf587 (191,541 bp) belongs to lineage IncA/C1 and is closely related to pRA1. It contains a large resistance island including the bla PER-2 gene between two copies of IS Kox2 -like elements, the toxin-antitoxin module pemK-pemI , several other resistance genes inserted within a Tn 2 transposon, a Tn 21 -like structure, and a class 1 integron. pCf587 belongs to sequence type 13 (ST13), a new plasmid multilocus sequence typing (pMLST) ST.
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29388340/early-history-of-the-different-forms-of-neurofibromatosis-from-ancient-egypt-to-the-british-empire-and-beyond-first-descriptions-medical-curiosities-misconceptions-landmarks-and-the-persons-behind-the-syndromes
#11
REVIEW
Martino Ruggieri, Andrea D Praticò, Rosario Caltabiano, Agata Polizzi
The earliest examples of neurofibromatosis (in this case type 1, NF1) can be traced in the Ebers Papyrus (Ancient Egypt, 1.500 B.C.), in a Hellenistic statuette (Smyrna, 323 B.C.), in the coinage of the Parthians kings (247 B.C.) and in some 13th century monks' drawings. These earlier examples are somewhat less well defined as compared to the most recent better defined reports credited as having NF1 including an Inca child mummy (1480-1650 AD), Ulisse Aldrovandi's homuncio ("Monstrorum Historia", 1592 A...
March 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29372680/antimicrobial-drug-resistance-in-fish-pathogens
#12
Ron A Miller, Heather Harbottle
Major concerns surround the use of antimicrobial agents in farm-raised fish, including the potential impacts these uses may have on the development of antimicrobial-resistant pathogens in fish and the aquatic environment. Currently, some antimicrobial agents commonly used in aquaculture are only partially effective against select fish pathogens due to the emergence of resistant bacteria. Although reports of ineffectiveness in aquaculture due to resistant pathogens are scarce in the literature, some have reported mass mortalities in Penaeus monodon larvae caused by Vibrio harveyi resistant to trimethoprim-sulfamethoxazole, chloramphenicol, erythromycin, and streptomycin...
January 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29370371/plasmids-carrying-antimicrobial-resistance-genes-in-enterobacteriaceae
#13
M Rozwandowicz, M S M Brouwer, J Fischer, J A Wagenaar, B Gonzalez-Zorn, B Guerra, D J Mevius, J Hordijk
Bacterial antimicrobial resistance (AMR) is constantly evolving and horizontal gene transfer through plasmids plays a major role. The identification of plasmid characteristics and their association with different bacterial hosts provides crucial knowledge that is essential to understand the contribution of plasmids to the transmission of AMR determinants. Molecular identification of plasmid and strain genotypes elicits a distinction between spread of AMR genes by plasmids and dissemination of these genes by spread of bacterial clones...
January 23, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29368373/purple-corn-associated-rhizobacteria-with-potential-for-plant-growth-promotion
#14
A Castellano-Hinojosa, V Pérez-Tapia, E J Bedmar, N Santillana
AIMS: Purple corn (Zea mays var. purple amylaceum) is a native variety of the Peruvian Andes, cultivated at 3000 m since pre-Inca times without N fertilization. We aimed to isolate and identify native plant growth promoting rhizobacteria (PGPR) for future microbial-based inoculants. METHODS AND RESULTS: Eighteen strains were isolated from the rhizosphere of purple corn plants grown without N-fertilization in Ayacucho (Peru). The 16S rRNA gene clustered the 18 strains into 9 groups that contained species of Bacillus, Stenotrophomonas, Achromobacter, Paenibacillus, Pseudomonas and Lysinibacillus...
January 24, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29314334/wheezing-and-infantile-colic-are-associated-with-neonatal-antibiotic-treatment
#15
Berthe C Oosterloo, Ruurd M van Elburg, Nicole B Rutten, Carin M Bunkers, Clarissa E Crijns, Clemens B Meijssen, Johanna H Oudshoorn, Ger T Rijkers, Cornelis K van der Ent, Arine M Vlieger
BACKGROUND: Cohort studies have suggested that early-life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk of atopic and non-atopic disorders. METHODS: The INCA study is a prospective observational birth cohort study of 436 term infants, with follow-up of 1 year; 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), vs a healthy untreated control group (N = 285; AB-)...
March 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29275118/rituximab-maintenance-versus-observation-following-abbreviated-induction-with-chemoimmunotherapy-in-elderly-patients-with-previously-untreated-chronic-lymphocytic-leukaemia-cll-2007-sa-an-open-label-randomised-phase-3-study
#16
Caroline Dartigeas, Eric Van Den Neste, Julie Léger, Hervé Maisonneuve, Christian Berthou, Marie-Sarah Dilhuydy, Sophie De Guibert, Stéphane Leprêtre, Marie C Béné, Florence Nguyen-Khac, Rémi Letestu, Florence Cymbalista, Philippe Rodon, Thérèse Aurran-Schleinitz, Jean-Pierre Vilque, Olivier Tournilhac, Béatrice Mahé, Kamel Laribi, Anne-Sophie Michallet, Alain Delmer, Pierre Feugier, Vincent Lévy, Roselyne Delépine, Philippe Colombat, Véronique Leblond
BACKGROUND: Most patients with chronic lymphocytic leukaemia relapse after initial therapy combining chemotherapy with rituximab. We assessed the efficacy and safety of rituximab maintenance treatment versus observation for elderly patients in remission after front-line abbreviated induction by fludarabine, cyclophosphamide, and rituximab (FCR). METHODS: This randomised, open-label, multicentre phase 3 trial at 89 centres in France enrolled treatment-naive and fit patients aged 65 years or older with chronic lymphocytic leukaemia without del(17p)...
February 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29233256/analysis-of-oxa-204-carbapenemase-producing-enterobacteriaceae-reveals-possible-endoscopy-associated-transmission-france-2012-to-2014
#17
Anaïs Potron, Sandrine Bernabeu, Gaëlle Cuzon, Valérie Pontiès, Hervé Blanchard, Elise Seringe, Thierry Naas, Patrice Nordmann, Laurent Dortet
OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204-positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing Enterobacteriaceae in Europe, involving 12 isolates of an ST90 Escherichia coli clone and nine isolates of an ST147 Klebsiella pneumoniae clone...
December 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29214501/mouse-embryonic-fibroblast-mef-bmp4-conditioned-medium-enhanced-multipotency-of-human-dental-pulp-cells
#18
Lu Liu, Zhengjun Peng, Zhezhen Xu, Haoquan Huang, Xi Wei
Dental pulp cells (DPCs) are valuable cell source for dental regeneration, albeit their application is restricted by limited pluripotency due to current culture condition. Mouse embryonic fibroblasts (MEFs) are served as feeder layer to maintain undifferentiated state of iPSCs and ESCs with long-term in vitro culture. Bone morphogenetic protein 4 (BMP4) plays an important role in the regulation of undifferentiated state and lineage commitment of cells through modulation of microenvironment. However, so far little was known how micro environment affect the multipotency of dental derived cells...
February 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29163422/a-novel-inca-c1-group-conjugative-plasmid-encoding-vim-1-metallo-beta-lactamase-mediates-the-acquisition-of-carbapenem-resistance-in-st104-klebsiella-pneumoniae-isolates-from-neonates-in-the-intensive-care-unit-of-v-monaldi-hospital-in-naples
#19
Eliana P Esposito, Stefano Gaiarsa, Mariateresa Del Franco, Valeria Crivaro, Mariano Bernardo, Susanna Cuccurullo, Francesca Pennino, Maria Triassi, Piero Marone, Davide Sassera, Raffaele Zarrilli
The emergence of carbapenemase producing Enterobacteriaceae has raised major public health concern. The aim of this study was to investigate the molecular epidemiology and the mechanism of carbapenem resistance acquisition of multidrug-resistant Klebsiella pneumoniae isolates from 20 neonates in the neonatal intensive care unit (NICU) of the V. Monaldi Hospital in Naples, Italy, from April 2015 to March 2016. Genotype analysis by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) identified PFGE type A and subtypes A1 and A2 in 17, 2, and 1 isolates, respectively, and assigned all isolates to sequence type (ST) 104...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29128409/breast-cancer-related-perceptions-and-practices-of-health-professionals-working-in-brazil-s-network-of-primary-care-units
#20
Benjamin D Hallowell, Douglas M Puricelli Perin, Eduardo J Simoes, Diana C Paez, Diana C Parra, Ross C Brownson, Mona Saraiya
In 2004 the Brazilian National Cancer Institute (INCA) established breast cancer screening guidelines for women in Brazil: annual clinical breast exam for women age 40-49 and biennial mammogram for women age 50-69. Healthcare provider's adherence to these guidelines is currently unknown. The objective of this study is to describe the perceptions and practices related to breast cancer screening among physicians, nurses, and health unit coordinators working in the network of primary healthcare units (HCUs) in Brazil...
January 2018: Preventive Medicine
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