keyword
https://read.qxmd.com/read/36978322/in-vitro-activity-of-ceftolozane-tazobactam-against-escherichia-coli-klebsiella-pneumoniae-and-pseudomonas-aeruginosa-obtained-from-blood-cultures-from-sentinel-public-hospitals-in-south-africa
#21
JOURNAL ARTICLE
Olga Perovic, Ashika Singh-Moodley, Michelle Lowe
Multidrug-resistant (MDR) Gram-negative bacteria are responsible for the majority of healthcare-associated infections and pose a serious threat as they complicate and prolong clinical care. A novel cephalosporin-β-lactamase-inhibitor combination, ceftolozane-tazobactam (C/T) was introduced in 2014, which improved the treatment of MDR pathogens. This study aimed to evaluate the activity of C/T against Escherichia coli (n = 100), Klebsiella pneumoniae (n = 100), and Pseudomonas aeruginosa (n = 100) blood culture isolates in South Africa (SA)...
February 24, 2023: Antibiotics
https://read.qxmd.com/read/36893553/dramatic-increase-in-slaughter-condemnations-due-to-escherichia-coli-st23-and-st101-within-the-danish-broiler-production
#22
JOURNAL ARTICLE
Sofie Kromann, Sharmin Baig, Rikke Heidemann Olsen, Sofie Marie Edslev, Ida Thøfner, Anders Miki Bojesen, Henrik Elvang Jensen, Marc Stegger
Escherichia coli constitutes a major challenge to poultry even when the prevalence of colibacillosis is low. Additionally, specific E. coli strains can severely enhance the detrimental effects on productivity, animal welfare and antimicrobial use. In 2019-2020, a dramatic increase in colibacillosis occurred among Danish broilers causing late-onset mortality and high slaughter condemnations. In the present study, the pathology and causative E. coli-types were characterised. Furthermore, the outbreak-related strains were compared to isolates from concurrent "background" colibacillosis...
February 19, 2023: Veterinary Microbiology
https://read.qxmd.com/read/36841076/first-detection-of-tet-x4-positive-enterobacterales-in-retail-vegetables-and-clonal-spread-of-escherichia-coli-st195-producing-tet-x4-in-animals-foods-and-humans-across-china-and-thailand
#23
JOURNAL ARTICLE
Chao Yue, Xun Gao, Litao Lu, Yi-Yun Liu, Lu-Chao Lv, Xiaotong He, Guolong Gao, Yanxiang Jiao, Huiying Yue, Wannan Lin, Jian-Hua Liu
The mobile tigecycline-resistant gene tet(X4), which confers resistance to all tetracyclines, has been identified in bacterial isolates from various sources. However, there are no reports on the occurrence of tet(X4) in bacterial isolates of ready-to-eat fresh vegetables. In this study, 113 vegetable samples from farmers' markets were screened for tigecycline-resistant strains. Ten Escherichia coli (two ST195, two ST48, and one ST10, ST58, ST88, ST394, ST641, and ST101) and one Klebsiella pneumoniae (ST327) recovered from nine vegetable samples (7...
February 21, 2023: International Journal of Food Microbiology
https://read.qxmd.com/read/36831248/targeting-transcription-factors-atf5-cebpb-and-cebpd-with-cell-penetrating-peptides-to-treat-brain-and-other-cancers
#24
REVIEW
Lloyd A Greene, Qing Zhou, Markus D Siegelin, James M Angelastro
Developing novel therapeutics often follows three steps: target identification, design of strategies to suppress target activity and drug development to implement the strategies. In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. We describe strategies that exploit the structures of the three factors to create inhibitory dominant-negative (DN) mutant forms that selectively suppress growth and survival of cancer cells...
February 11, 2023: Cells
https://read.qxmd.com/read/36830261/whole-genome-sequencing-snapshot-of-clinically-relevant-carbapenem-resistant-gram-negative-bacteria-from-wastewater-in-serbia
#25
JOURNAL ARTICLE
Ivana Cirkovic, Bruno H Muller, Ana Janjusevic, Patrick Mollon, Valérie Istier, Caroline Mirande-Meunier, Snezana Brkic
Wastewater (WW) is considered a source of antibiotic-resistant bacteria with clinical relevance and may, thus, be important for their dissemination into the environment, especially in countries with poor WW treatment. To obtain an overview of the occurrence and characteristics of carbapenem-resistant Gram-negative bacteria (CR-GNB) in WW of Belgrade, we investigated samples from the four main sewer outlets prior to effluent into international rivers, the Sava and the Danube. Thirty-four CR-GNB isolates were selected for antimicrobial susceptibility testing (AST) and whole-genome sequencing (WGS)...
February 8, 2023: Antibiotics
https://read.qxmd.com/read/36816594/outbreak-of-colistin-resistant-carbapenemase-bla-ndm-bla-oxa-232-producing-klebsiella-pneumoniae-causing-blood-stream-infection-among-neonates-at-a-tertiary-care-hospital-in-india
#26
JOURNAL ARTICLE
Ashutosh Pathak, Nidhi Tejan, Akanksha Dubey, Radha Chauhan, Nida Fatima, Jyoti, Sushma Singh, Sahil Bhayana, Chinmoy Sahu
Infections caused by multi-drug resistant Klebsiella pneumoniae are a leading cause of mortality and morbidity among hospitalized patients. In neonatal intensive care units (NICU), blood stream infections by K. pneumoniae are one of the most common nosocomial infections leading to poor clinical outcomes and prolonged hospital stays. Here, we describe an outbreak of multi-drug resistant K. pneumoniae among neonates admitted at the NICU of a large tertiary care hospital in India. The outbreak involved 5 out of 7 neonates admitted in the NICU...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/36723699/genome-based-characterization-of-multidrug-resistant-escherichia-coli-isolated-from-clinical-bovine-mastitis
#27
JOURNAL ARTICLE
Taila Dos Santos Alves, Vinícius Sanches Rosa, Domingos da Silva Leite, Simony Trevizan Guerra, Sâmea Fernandes Joaquim, Felipe Freitas Guimarães, José Carlos de Figueiredo Pantoja, Simoni Baldini Lucheis, Vera Lúcia Mores Rall, Rodrigo Tavanelli Hernandes, Helio Langoni, Márcio Garcia Ribeiro
Mastitis occurrence in dairy cows is a broad topic that involves several sectors, from antimicrobial resistance and virulence of strains to economic implications and cattle management practices. Here, we assessed the molecular characterization (antimicrobial resistance determinants, virulence genes, sequences type, serotypes, and plasmid types) of 178 Escherichia coli strains isolated from milk samples from cows with clinical mastitis using a genome-based k-mers approach. Of these, 53 (29.8%) showed multidrug resistance by disc diffusion...
February 1, 2023: Current Microbiology
https://read.qxmd.com/read/36708818/resistance-to-critically-important-antibiotics-in-hospital-wastewater-from-the-largest-croatian-city
#28
JOURNAL ARTICLE
Ana Puljko, Svjetlana Dekić Rozman, Ivan Barišić, Ana Maravić, Marko Jelić, Ivana Babić, Milena Milaković, Ines Petrić, Nikolina Udiković-Kolić
The emergence of extended-spectrum β-lactamase (ESBL)- and especially carbapenemases in Enterobacterales has led to limited therapeutic options. Therefore, it is critical to fully understand all potential routes of transmission, especially in high-risk sources such as hospital wastewater. This study aimed to quantify four enteric opportunistic pathogens (EOPs), total, ESBL- and carbapenem-resistant coliforms and their corresponding resistance genes (two ESBL and five carbapenemase genes) and to characterize enterobacterial isolates from hospital wastewater from two large hospitals in Zagreb over two seasons...
January 25, 2023: Science of the Total Environment
https://read.qxmd.com/read/36683114/molecular-characterization-of-colistin-resistance-genes-in-a-high-risk-st101-kpc-2-clone-of-klebsiella-pneumoniae-in-a-university-hospital-of-split-croatia
#29
JOURNAL ARTICLE
Zana Rubic, Marko Jelic, Silvija Soprek, Maja Tarabene, Josip Ujevic, Ivana Goic-Barisic, Anita Novak, Marina Radic, Arjana Tambic Andrasevic, Marija Tonkic
Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) has become a major concern worldwide due to multidrug resistance and the ability to spread locally and globally. Infections caused by KPC-KP are great challenge in the healthcare systems because these are associated with longer hospitalization and high mortality. The emergence of colistin resistance has significantly reduced already limited treatment options. This study describes the molecular background of colistin-resistant KPC-KP isolates in the largest hospital in southern Croatia...
January 23, 2023: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/36611699/prevalence-and-persistence-of-ceftiofur-resistant-escherichia-coli-in-a-chicken-layer-breeding-program
#30
JOURNAL ARTICLE
Meina Liao, Jiaen Wu, Yafei Li, Xiaoqing Lu, Huizhen Tan, Shanshan Chen, Wenqing Huang, Xinlei Lian, Jian Sun, Xiaoping Liao, Yahong Liu, Saixiang Feng, Rongmin Zhang
We determined the longitudinal persistence of ceftiofur-resistant Escherichia coli from a chicken breeding farm in China. A total of 150 samples were collected from 5 breeding periods in a flock of layer hens, and the prevalence of ceftiofur-resistant E. coli fluctuated across the 5 chicken breeding stages: eggs, 3.33%; growing period, 100%; early laying period, 36.7%; peak laying period, 66.7% and late laying period, 80%. The most prevalent ceftiofur resistance genes were bla CTX-M-55 , bla CMY and bla NDM , and ST101 was the most prevalent and persistent sequence type across the breeding periods...
December 26, 2022: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/36422353/characterization-of-genomic-diversity-among-carbapenem-resistant-escherichia-coli-clinical-isolates-and-antibacterial-efficacy-of-silver-nanoparticles-from-pakistan
#31
JOURNAL ARTICLE
Aamir Jamal Gondal, Nakhshab Choudhry, Hina Bukhari, Zainab Rizvi, Nighat Yasmin
The emergence of carbapenem-resistant Escherichia coli ( E. coli ) is considered an important threat to public health resulting in resistance accumulation due to antibiotics misuse and selection pressure. This warrants periodic efforts to investigate and develop strategies for infection control. A total of 184 carbapenem-resistant clinical strains of E. coli were characterized for resistance pattern, resistance genes, plasmids, sequence types and in vitro efficacy of silver nanoparticles (AgNPs). Carbapenem resistance was prevalent in E...
November 17, 2022: Microorganisms
https://read.qxmd.com/read/36421315/colistin-resistance-mechanisms-in-human-and-veterinary-klebsiella-pneumoniae-isolates
#32
JOURNAL ARTICLE
Manuela Tietgen, Lisa Sedlaczek, Paul G Higgins, Heike Kaspar, Christa Ewers, Stephan Göttig
Colistin (polymyxin E) is increasingly used as a last-resort antibiotic for the treatment of severe infections with multidrug-resistant Gram-negative bacteria. In contrast to human medicine, colistin is also used in veterinary medicine for metaphylaxis. Our objective was to decipher common colistin resistance mechanisms in Klebsiella pneumoniae isolates from animals. In total, 276 veterinary K. pneumoniae isolates, derived from companion animals or livestock, and 12 isolates from human patients were included for comparison...
November 21, 2022: Antibiotics
https://read.qxmd.com/read/36414199/deciphering-variable-resistance-to-novel-carbapenem-based-%C3%AE-lactamase-inhibitor-combinations-in-a-multi-clonal-outbreak-caused-by-klebsiella-pneumoniae-carbapenemase-kpc-producing-klebsiella-pneumoniae-resistant-to-ceftazidime-avibactam
#33
JOURNAL ARTICLE
Vincenzo Di Pilato, Luigi Principe, Lilia Andriani, Noemi Aiezza, Marco Coppi, Silvia Ricci, Tommaso Giani, Francesco Luzzaro, Gian Maria Rossolini
OBJECTIVES: Carbapenemase-producing Enterobacterales represent a major cause of difficult-to-treat infections world-wide. Novel β-lactam/β-lactamase inhibitor combinations, including ceftazidime/avibactam (CZA), meropenem/vaborbactam (MVB), and imipenem/relebactam (IMR), represented a break-through in the treatment of some carbapenemase-producing Enterobacterales infections. However, acquired resistance to these agents has been reported in Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales...
November 19, 2022: Clinical Microbiology and Infection
https://read.qxmd.com/read/36318798/sequencing-of-fosa-a-rapid-and-inexpensive-method-for-discriminating-klebsiella-pneumoniae-cc258-from-other-clones
#34
JOURNAL ARTICLE
Ághata Cardoso da Silva Ribeiro, Fernanda Fernandes Santos, Ikechukwu Benjamin Moses, Luciene Andrade da Rocha Minarini, Ana Cristina Gales
Typing carbapenem-resistant Klebsiella pneumoniae (CR-KPN) is crucial in controlling their dissemination and solving outbreaks. In this context, we searched for an effective, faster, and cheaper alternative technique to type KPN by analyzing the fosA KP sequence. We analyzed the nucleotide sequences of chromosomal fosA KP gene in 350 KPN genomes (70 per sequence type [ST] or clonal complex [CC]). Assembly genomes were randomly downloaded from NCBI and annotated using RAST in PATRIC platform. The isolate STs were verified using multilocus sequence typing 2...
November 1, 2022: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/36204614/resistance-and-virulence-features-of-hypermucoviscous-klebsiella-pneumoniae-from-bloodstream-infections-results-of-a-nationwide-italian-surveillance-study
#35
JOURNAL ARTICLE
Fabio Arena, Giulia Menchinelli, Vincenzo Di Pilato, Riccardo Torelli, Alberto Antonelli, Lucia Henrici De Angelis, Marco Coppi, Maurizio Sanguinetti, Gian Maria Rossolini
Among Enterobacterales, Klebsiella pneumoniae (Kp) is one of the major opportunistic pathogens causing hospital-acquired infections. The most problematic phenomenon linked to Kp is related to the dissemination of multi-drug resistant (MDR) clones producing carbapenem-hydrolyzing enzymes, representing a clinical and public health threat at a global scale. Over the past decades, high-risk MDR clones (e.g., ST512, ST307, ST101 producing bla KPC-type carbepenemases) have become endemic in several countries, including Italy...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/36139950/characterization-of-carbapenemase-producing-klebsiella-pneumoniae-isolates-from-two-romanian-hospitals-co-presenting-resistance-and-heteroresistance-to-colistin
#36
JOURNAL ARTICLE
Annamária Főldes, Mihaela Oprea, Edit Székely, Codruța-Romanița Usein, Minodora Dobreanu
Klebsiella pneumoniae is a notorious human pathogen involved in healthcare-associated infections. The worldwide expansion of infections induced by colistin-resistant and carbapenemase-producing Enterobacterales (CPE) isolates has been increasingly reported. This study aims to analyze the phenotypic and molecular profiles of 10 colistin-resistant (CR) isolates and 2 pairs of colistin-heteroresistant (ChR) (parental and the corresponding resistant mutants) isolates of K. pneumoniae CPE sourced from two hospitals...
August 30, 2022: Antibiotics
https://read.qxmd.com/read/36139932/distribution-and-genomic-characterization-of-third-generation-cephalosporin-resistant-escherichia-coli-isolated-from-a-single-family-and-home-environment-a-2-year-longitudinal-study
#37
JOURNAL ARTICLE
Yin-Chih Feng, Ci-Hong Liou, Wailap Victor Ng, Feng-Jui Chen, Chih-Hsin Hung, Po-Yen Liu, Yu-Chieh Liao, Han-Chieh Wu, Ming-Fang Cheng
Third-generation cephalosporin-resistant Escherichia coli (CREC), particularly strains producing extended-spectrum β-lactamases (ESBLs), are a global concern. Our study aims to longitudinally assemble the genomic characteristics of CREC isolates from fecal samples from an index patient with recurrent CREC-related urinary tract infections and his family and swabs from his home environment 12 times between 2019 and 2021 to investigate the distribution of antibiotic resistance genes. CREC identified using the VITEK 2 were subjected to nanopore whole-genome sequencing (WGS)...
August 25, 2022: Antibiotics
https://read.qxmd.com/read/36136656/molecular-epidemiological-characterisation-of-esbl-and-plasmid-mediated-ampc-producing-escherichia-coli-and-klebsiella-pneumoniae-at-kamuzu-central-hospital-lilongwe-malawi
#38
JOURNAL ARTICLE
Faheema Ebrahim Choonara, Bjørg Christina Haldorsen, Jessin Janice, Joshua Mbanga, Isaac Ndhlovu, Osborne Saulosi, Tarsizio Maida, Fanuel Lampiao, Gunnar Skov Simonsen, Sabiha Yusuf Essack, Arnfinn Sundsfjord
The global rise in infections caused by multidrug resistant (MDR) Enterobacterales poses a public health problem. We have performed a molecular epidemiological characterisation of representative plasmid-mediated AmpC (pAmpC) and ESBL-positive clinical isolates of Escherichia coli (n = 38) and Klebsiella pneumoniae (n = 17) from a tertiary hospital in Malawi collected in 2017. Bla CTX-M-15 was the most prevalent ESBL-determinant in E. coli (n = 30/38) and K. pneumoniae (n = 17/17), whereas bla CMY-2 was detected in nearly all AmpC-phenotype E...
September 14, 2022: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/36121385/anti-cancer-activity-of-st101-a-novel-antagonist-of-ccaat-enhancer-binding-protein-%C3%AE
#39
JOURNAL ARTICLE
Emad Darvishi, Lila Ghamsari, Siok F Leong, Ricardo Ramirez, Mark Koester, Erin Gallagher, Miao Yu, Jody M Mason, Gene Merutka, Barry J Kappel, Jim A Rotolo
CCAAT/Enhancer Binding Protein β (C/EBPβ) is a basic leucine zipper (bZIP) family transcription factor that is upregulated or overactivated in many cancers, resulting in gene transactivation that drives oncogenesis. C/EBPβ dimerization regulates binding to DNA at the canonical TTGCGCAA motif and subsequent transcriptional activity, suggesting that disruption of dimerization represents a powerful approach to inhibit this previously 'undruggable' oncogenic target. Here we describe the mechanism of action and anti-tumor activity of ST101, a novel and selective peptide antagonist of C/EBPβ that is currently in clinical evaluation in patients with advanced solid tumors...
September 19, 2022: Molecular Cancer Therapeutics
https://read.qxmd.com/read/36089853/global-spread-and-evolutionary-convergence-of-multidrug-resistant-and-hypervirulent-klebsiella-pneumoniae-high-risk-clones
#40
JOURNAL ARTICLE
Gabriele Arcari, Alessandra Carattoli
For people living in developed countries life span is growing at a faster pace than ever. One of the main reasons for such success is attributable to the introduction and extensive use in the clinical practice of antibiotics over the course of the last seven decades. In hospital settings, Klebsiella pneumoniae represents a well-known and commonly described opportunistic pathogen, typically characterized by resistance to several antibiotic classes. On the other hand, the broad wedge of population living in Low and/or Middle Income Countries is increasing rapidly, allowing the spread of several commensal bacteria which are transmitted via human contact...
September 11, 2022: Pathogens and Global Health
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