keyword
https://read.qxmd.com/read/38440985/clinical-microbiological-and-molecular-characterization-of-pediatric-invasive-infections-by-streptococcus-pyogenes-in-spain-in-a-context-of-global-outbreak
#1
JOURNAL ARTICLE
Eva Ramírez de Arellano, Jesús Saavedra-Lozano, Pilar Villalón, Ana Jové-Blanco, David Grandioso, Jared Sotelo, Anna Gamell, Juan José González-López, Eloísa Cervantes, María José Gónzalez, Victoria Rello-Saltor, Cristina Esteva, Francisco Sanz-Santaeufemia, Genoveva Yagüe, Ángela Manzanares, Patricia Brañas, Enrique Ruiz de Gopegui, Jaime Carrasco-Colom, Federico García, Emilia Cercenado, Isabel Mellado, Elena Del Castillo, María Pérez-Vazquez, Jesús Oteo-Iglesias, Cristina Calvo
UNLABELLED: In December 2022, an alert was published in the UK and other European countries reporting an unusual increase in the incidence of Streptococcus pyogenes infections. Our aim was to describe the clinical, microbiological, and molecular characteristics of group A Streptococcus invasive infections (iGAS) in children prospectively recruited in Spain (September 2022-March 2023), and compare invasive strains with strains causing mild infections. One hundred thirty isolates of S. pyogenes causing infection (102 iGAS and 28 mild infections) were included in the microbiological study: emm typing, antimicrobial susceptibility testing, and sequencing for core genome multilocus sequence typing (cgMLST), resistome, and virulome analysis...
March 5, 2024: MSphere
https://read.qxmd.com/read/38346310/molecular-characteristics-and-virulence-profile-of-clinical-listeria-monocytogenes-isolates-in-northern-taiwan-2009-2019
#2
JOURNAL ARTICLE
Tsui-Ping Liu, Lee-Chung Lin, Shih-Cheng Chang, Yu-Hsiang Ou, Jang-Jih Lu
Listeria monocytogenes is a critical foodborne pathogen that causes severe invasive and noninvasive diseases and is associated with high mortality. Information on the prevalence of L. monocytogenes infections in Taiwan is very limited. This study aimed to analyze the molecular epidemiological surveillance and virulence gene distribution of 176 human clinical L. monocytogenes isolates collected between 2009 and 2019 in northern Taiwan. Our results showed that the isolates belonged to 4 serogroups (IIa, IIb, IVb, and IIc), with most isolates in serogroups IIa (81/176, 46%) and IIb (71/176, 40...
February 12, 2024: Foodborne Pathogens and Disease
https://read.qxmd.com/read/38291521/clinically-relevant-sequence-types-of-carbapenemase-producing-escherichia-coli-and-klebsiella-pneumoniae-detected-in-finnish-wastewater-in-2021-2022
#3
JOURNAL ARTICLE
Viivi Heljanko, Olga Tyni, Venla Johansson, Jussa-Pekka Virtanen, Kati Räisänen, Kirsi-Maarit Lehto, Anssi Lipponen, Sami Oikarinen, Tarja Pitkänen, Annamari Heikinheimo
BACKGROUND: Antimicrobial resistance (AMR) is a critical threat to human health. Escherichia coli and Klebsiella pneumoniae are clinically the most important species associated with AMR and are the most common carbapenemase-producing (CP) Enterobacterales detected in human specimens in Finland. Wastewater surveillance has emerged as a potential approach for population-level surveillance of AMR, as wastewater could offer a reflection from a larger population with one sample and minimal recognized ethical issues...
January 30, 2024: Antimicrobial Resistance and Infection Control
https://read.qxmd.com/read/38289935/one-year-surveillance-for-hypervirulent-klebsiella-pneumoniae-detected-carbapenem-resistant-superbugs
#4
JOURNAL ARTICLE
C Merla, A Kuka, I Mileto, G Petazzoni, S Gaiarsa, D De Vitis, M Ardizzone, M Corbella, F Baldanti, P Cambieri
Hypervirulent Klebsiella pneumoniae (hvKp) can cause infections in clinically healthy people, such as young and immunocompetent patients. Genes involved in the capsule synthesis or those encoding the siderophores have been adopted as predictors of hvKp. Certain sequence types, such as ST23 and ST86, have been associated with hvKp strains, too. The aim of this study was to investigate the presence of hvKp among 354 K. pneumoniae strains isolated from clinical samples of patients admitted to an Italian 900-bed hospital between 21 May 2021 and April 2022...
January 30, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38247640/in-vitro-antimicrobial-activity-of-five-newly-approved-antibiotics-against-carbapenemase-producing-enterobacteria-a-pilot-study-in-bulgaria
#5
JOURNAL ARTICLE
Rumyana Markovska, Petya Stankova, Temenuga Stoeva, Emma Keuleyan, Kalina Mihova, Lyudmila Boyanova
To solve the problem with pan-drug resistant and extensively drug-resistant Gram-negative microbes, newly approved drugs such as ceftazidime/avibactam, cefiderocol, plazomicin, meropenem/vaborbactam, and eravacycline have been introduced in practice. The aim of the present study was to collect carbapenemase-producing clinical Enterobacterales isolates, to characterize their carbapenemase genes and clonal relatedness, and to detect their susceptibility to commonly used antimicrobials and the above-mentioned newly approved antibiotics...
January 15, 2024: Antibiotics
https://read.qxmd.com/read/38193903/occurrence-of-imipenem-resistant-uropathogenic-escherichia-coli-in-pregnant-women-an-insight-into-their-virulence-profile-and-clonal-structure
#6
JOURNAL ARTICLE
Snehashis Koley, Arunita Ghosh, Mandira Mukherjee
Uropathogenic Escherichia coli (UPEC) is the predominant pathogen in Urinary Tract Infection (UTI) in pregnant and non-pregnant women. Limited studies were initiated to explore UPEC from pregnant women with respect to imipenem resistance, pathogenicity, and their clonal lineage. In this study, imipenem resistance, phylogenetic background, virulence-associated genes, and clonal characteristics in UPECs isolated from pregnant and non-pregnant cohorts were investigated. E. coli was identified biochemically from urine culture-positive samples from pregnant and non-pregnant women...
January 9, 2024: Current Microbiology
https://read.qxmd.com/read/38063903/high-risk-clonal-lineages-among-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli%C3%A2-and-klebsiella-pneumoniae-from-urban-and%C3%A2-rural-stagnant-water-samples-in-tunisia
#7
JOURNAL ARTICLE
Amel Romdhani, Sarah Cheriet, Mohamed Salah Abbassi, Sana Lengliz, Paul Hynds, Ilhem Boutiba-Ben Boubaker, Ramzi Boubaker Landolsi
This study sought to investigate the occurrence and subsequently to characterize extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae from urban and rural stagnant water samples during the wet season (December to February) in several regions of northern Tunisia. From 56 stagnant water samples, 14 ESBL-producing Enterobacteriaceae were recovered, including 9 Escherichia coli, 3 Klebsiella pneumoniae, and 2 K. oxytoca. Most isolates were multidrug-resistant, with ESBL production primarily encoded by blaCTX-M-15 (n = 8) and blaCTX-M-1 (n = 4) followed by blaCTX-M-55 (n = 1) and blaTEM-26 (n = 1)...
December 7, 2023: Acta Microbiologica et Immunologica Hungarica
https://read.qxmd.com/read/37972778/insights-into-the-genetic-diversity-of-listeria-monocytogenes-from-bivalves
#8
JOURNAL ARTICLE
Arkadiusz Józef Zakrzewsk, Joanna Gajewska, Wioleta Chajęcka-Wierzchowska, Anna Zadernowska
In the present study, 30 L. monocytogenes strains isolated from bivalves purchased in Poland were characterized by whole genome sequencing (WGS). The Core Genome Multilocus Sequence Typing (cgMLST) analysis revealed that the most frequent serogroups were IIa; sequence types (ST) were ST101, ST21 and ST325; and clonal complexe (CC) were CC101. Despite differential genotypic subtypes, most strains had similar antimicrobial resistance profiles. Most strains had genetic determinants of resistance to many groups of antibiotics; aminoglycosides, fluoroquinolones, lincosamides, macrolides, peptides, phosphotic acids and sulfonamides...
November 14, 2023: Science of the Total Environment
https://read.qxmd.com/read/37966203/genomic-analysis-reveals-the-presence-of-emerging-pathogenic-klebsiella-lineages-aboard-the-international-space-station
#9
JOURNAL ARTICLE
Georgios Miliotis, Francesca McDonagh, Nitin Kumar Singh, Louise O'Connor, Alma Tuohy, Dearbháile Morris, Kasthuri Venkateswaran
The International Space Station (ISS) is a unique, hermetically sealed environment, subject to environmental pressures not encountered on Earth, including microgravity and radiation (cosmic ionising/UV). While bacteria's adaptability during spaceflight remains elusive, recent research suggests that it may be species and even clone-specific. Considering the documented spaceflight-induced suppression of the human immune system, a deper understanding of the genomics of potential human pathogens in space could shed light on species and lineages of medical astromicrobiological significance...
November 15, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37891628/evaluating-molecular-epidemiology-of-carbapenem-non-susceptible-klebsiella-pneumoniae-isolates-with-mlst-maldi-tof-ms-pfge
#10
JOURNAL ARTICLE
Yunus Emre Ibik, Nebahat Ejder, Elif Sevim, Erva Rakici, Elif Seren Tanriverdi, Aysegül Copur Cicek
BACKGROUND: This study aimed to evaluate antibiotic resistance genes and virulence genes and the clonal relationship of the carbapenem-nonsusceptible Klebsiella pneumoniae strains by molecular methods which are isolated from various clinical specimens from patients treated in tertiary care hospital in Turkey. METHODS: Identification of 32 carbapenem non-susceptible K. pneumoniae were determined by VITEK-2 (BioMérieux, France) automated system. Thirteen colistin-resistant strains were tested with the broth microdilution method...
October 27, 2023: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/37883425/genome-analysis-of-third-generation-cephalosporin-resistant-escherichia-coli-and-salmonella-species-recovered-from-healthy-and-diseased-food-producing-animals-in-europe
#11
JOURNAL ARTICLE
Marlène Sauget, Alban K Atchon, Benoît Valot, Farid El Garch, Anno de Jong, Hilde Moyaert, Didier Hocquet
The animal reservoir of Enterobacterales producing Extended-Spectrum-β-Lactamases (ESBL) and plasmid-borne cephalosporinases (pAmpC) is a global concern. Using genome data, we analyzed a population of Escherichia coli and Salmonella species resistant to third-generation cephalosporins (3GC-R) recovered from healthy food animals (HA) and diseased food animals (DA) across Europe. Among the isolates collected from HA (n = 4,498) and DA (n = 833) in up to twelve European countries, 62 (1.4%) and 45 (5.4%) were 3GC-R, respectively...
2023: PloS One
https://read.qxmd.com/read/37879456/epidemiology-risk-factors-and-clinical-outcomes-of-carbapenem-resistant-enterobacterales-in-africa-a-systematic-review
#12
REVIEW
Moloto Kedišaletše, Dube Phumuzile, Dramowski Angela, Whitelaw Andrew, Newton-Foot Mae
BACKGROUND: Carbapenem-resistant Enterobacterales (CRE) commonly cause hospital-acquired infections and hospital outbreaks worldwide, with an alarming increase in Africa, necessitating review of regional CRE epidemiological trends. METHODS: A systematic review was conducted using PRISMA guidelines, searching PubMed, Scopus and Web of Science databases for studies describing CRE distribution, risk factors for CRE acquisition and clinical outcome of CRE infections in Africa...
October 23, 2023: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/37875024/nosocomial-dissemination-of-blaimp-4-among-klebsiella-pneumoniae-by-horizontal-gene-transfer-and-clonal-spread-the-epidemic-incn-plasmids-and-the-emerging-high-risk-imp-4-producing-st101-clone
#13
JOURNAL ARTICLE
Xing Wang, Jie Qin, Guoxiu Xiang, Chen Wang, Qichen Wang, Juanxiu Qin, Haiying Wang, Zhen Shen
OBJECTIVES: To determine the genomic features of IMP-4-producing Klebsiella pneumoniae isolates recovered from paediatric patients and the transmission dynamics of blaIMP-4. METHODS: IMP-producing K. pneumoniae isolates were collected from paediatric patients in Shanghai Children's Medical Center from 2013 to 2020. WGS was performed for all isolates, and the complete genomes of three IMP-4-producing isolates were generated. The distribution of blaIMP-4-harbouring plasmids was determined, and a conjugation assay was employed to investigate the horizontal transfer of blaIMP-4-harbouring plasmids...
October 24, 2023: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/37760726/clonal-plasmidic-and-genetic-diversity-of-multi-drug-resistant-enterobacterales-from-hospitalized-patients-in-tripoli-libya
#14
JOURNAL ARTICLE
Nada Elgriw, Véronique Métayer, Antoine Drapeau, Pauline François, Sana Azaiez, Maha Mastouri, Hajer Rhim, Adam Elzagheid, Najeeb Soufiyah, Jean-Yves Madec, Cherifa Chaouch, Wejdene Mansour, Marisa Haenni
Resistance to extended-spectrum cephalosporins (ESC) and carbapenems in Enterobacterales is a major issue in public health. Carbapenem resistance in particular is associated with increased morbidity and mortality. Moreover, such resistance is often co-harbored with resistance to non-beta-lactam antibiotics, and pathogens quickly become multi-drug-resistant (MDR). Only a few studies have been published on AMR in Libyan hospitals, but all reported worrisome results. Here, we studied 54 MDR isolates that were collected from 49 patients at the Tripoli University Hospital between 2019 and 2021...
September 10, 2023: Antibiotics
https://read.qxmd.com/read/37627702/whole-genome-sequencing-and-molecular-analysis-of-ceftazidime-avibactam-resistant-kpc-producing-klebsiella-pneumoniae-from-intestinal-colonization-in-elderly-patients
#15
JOURNAL ARTICLE
Giulia Errico, Maria Del Grosso, Michela Pagnotta, Manuela Marra, Maria Carollo, Marina Cerquetti, Elena Fogato, Elisabetta Cesana, Flaminia Gentiloni Silverj, Dorjan Zabzuni, Angelo Rossini, Annalisa Pantosti, Marco Tinelli, Monica Monaco, Maria Giufrè
Ceftazidime-avibactam (CAZ-AVI) is an active antibiotic combination of a β-lactam-β-lactamase inhibitor against carbapenemase-producing Enterobacterales. Reports of resistance to CAZ-AVI other than metallo-β-lactamases have increased in recent years. The aim of this study was to analyze KPC- Klebsiella pneumoniae (KP) isolates resistant to CAZ-AVI from the intestinal carriage of hospitalized elderly patients in Italy, in February 2018-January 2020. Characterization of CAZ-AVI-resistant KP isolates, including MLST, resistome, virulome and plasmid content, was performed by WGS analysis...
August 3, 2023: Antibiotics
https://read.qxmd.com/read/37626228/multi-locus-sequence-typing-and-in-vitro-antimicrobial-resistance-of-equine-streptococcus-equi-subspecies-zooepidemicus-strains
#16
JOURNAL ARTICLE
Francesca Paola Nocera, Loredana Capozzi, Domenico Simone, Francesca Pizzano, Valentina Iovane, Angelica Bianco, Antonio Parisi, Luisa De Martino
Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is one of the most important pathogens frequently associated with the main causes of equine infertility. In this study, we surveyed 22 strains of S. zooepidemicus collected during 2021 from cervico-uterine swabs of mares with endometritis. The genetic variability of the isolated strains was studied by multi-locus sequence typing (MLST) from whole-genome sequencing (WGS) data. The average length of reconstructed genomes was 2,088,286 bp (95% CI: 2,061,569 bp-2,114,967 bp), which was expected for S...
August 26, 2023: Veterinary Research Communications
https://read.qxmd.com/read/37394034/comparative-genetic-characterisation-of-third-generation-cephalosporin-resistant-escherichia-coli-isolated-from-integrated-and-conventional-pig-farm-in-korea
#17
JOURNAL ARTICLE
Kwang Won Seo, Kyung-Hyo Do, Chang Min Jung, Seong Won Lee, Young Ju Lee, Suk-Kyung Lim, Wan-Kyu Lee
OBJECTIVES: Pig-farming systems consist of integrated or conventional farms, and many antimicrobials are used to treat bacterial infections. The objective of this study was to compare characteristics of third-generation cephalosporin resistance and extended-spectrum β-lactamase (ESBL)/pAmpC β-lactamase-producing Escherichia coli between integrated and conventional farms. METHODS: Third-generation cephalosporin-resistant E. coli was collected from integrated and conventional pig farms from 2021 to 2022...
July 1, 2023: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/37310221/widespread-detection-of-yersiniabactin-gene-cluster-and-its-encoding-integrative-conjugative-elements-ice-kp-among-nonoutbreak-oxa-48-producing-klebsiella-pneumoniae-clinical-isolates-from-spain-and-the-netherlands
#18
JOURNAL ARTICLE
Afif P Jati, Pedro J Sola-Campoy, Thijs Bosch, Leo M Schouls, Antoni P A Hendrickx, Verónica Bautista, Noelia Lara, Erwin Raangs, Belén Aracil, John W A Rossen, Alex W Friedrich, Ana M Navarro Riaza, Javier E Cañada-García, Eva Ramírez de Arellano, Jesús Oteo-Iglesias, María Pérez-Vázquez, Silvia García-Cobos, Ana María Fernández Sánchez, Ma Angeles Pulido, Mayuli Armas
In this study, we determined the presence of virulence factors in nonoutbreak, high-risk clones and other isolates belonging to less common sequence types associated with the spread of OXA-48-producing Klebsiella pneumoniae clinical isolates from The Netherlands ( n  = 61) and Spain ( n  = 53). Most isolates shared a chromosomally encoded core of virulence factors, including the enterobactin gene cluster, fimbrial fim and mrk gene clusters, and urea metabolism genes ( ureAD ). We observed a high diversity of K-Locus and K/O loci combinations, KL17 and KL24 (both 16%), and the O1/O2v1 locus (51%) being the most prevalent in our study...
June 13, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37272914/genomic-analysis-of-the-initial-dissemination-of-carbapenem-resistant-klebsiella-pneumoniae-clones-in-a-tertiary-hospital
#19
JOURNAL ARTICLE
Neris Garcia-Gonzalez, Begoña Fuster, Nuria Tormo, Carme Salvador, Concepcion Gimeno, Fernando Gonzalez-Candelas
Carbapenem-resistant Klebsiella pneumoniae is a major cause of hospital-acquired infections and the fastest-growing pathogen in Europe. Carbapenem resistance was detected at the Consorcio Hospital General Universitario de Valencia (CHGUV) in early 2015, and there has been a significant increase in carbapenem-resistant isolates since then. In this study, we collected carbapenem-resistant isolates from this hospital during the period of increase (from 2015 to 2019) and studied how K. pneumoniae carbapenem-resistant isolates emerged and spread in the hospital...
June 2023: Microbial Genomics
https://read.qxmd.com/read/36978392/estimation-evaluation-and-characterization-of-carbapenem-resistance-burden-from-a-tertiary-care-hospital-pakistan
#20
JOURNAL ARTICLE
Aamir Jamal Gondal, Nakhshab Choudhry, Hina Bukhari, Zainab Rizvi, Shah Jahan, Nighat Yasmin
Carbapenem resistance has become major concern in healthcare settings globally; therefore, its monitoring is crucial for intervention efforts to halt resistance spread. During May 2019-April 2022, 2170 clinical strains were characterized for antimicrobial susceptibility, resistance genes, replicon and sequence types. Overall, 42.1% isolates were carbapenem-resistant, and significantly associated with Klebsiella pneumoniae ( K. pneumoniae ) ( p = 0.008) and Proteus species ( p = 0.043). Carbapenemases were detected in 82...
March 6, 2023: Antibiotics
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