Eva Ramírez de Arellano, Jesús Saavedra-Lozano, Pilar Villalón, Ana Jové-Blanco, David Grandioso, Jared Sotelo, Anna Gamell, Juan José González-López, Eloísa Cervantes, María José Gónzalez, Victoria Rello-Saltor, Cristina Esteva, Francisco Sanz-Santaeufemia, Genoveva Yagüe, Ángela Manzanares, Patricia Brañas, Enrique Ruiz de Gopegui, Jaime Carrasco-Colom, Federico García, Emilia Cercenado, Isabel Mellado, Elena Del Castillo, María Pérez-Vazquez, Jesús Oteo-Iglesias, Cristina Calvo
UNLABELLED: In December 2022, an alert was published in the UK and other European countries reporting an unusual increase in the incidence of Streptococcus pyogenes infections. Our aim was to describe the clinical, microbiological, and molecular characteristics of group A Streptococcus invasive infections (iGAS) in children prospectively recruited in Spain (September 2022-March 2023), and compare invasive strains with strains causing mild infections. One hundred thirty isolates of S. pyogenes causing infection (102 iGAS and 28 mild infections) were included in the microbiological study: emm typing, antimicrobial susceptibility testing, and sequencing for core genome multilocus sequence typing (cgMLST), resistome, and virulome analysis...
March 5, 2024: MSphere