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https://www.readbyqxmd.com/read/28526682/aeroallergens-induce-reactive-oxygen-species-production-and-dna-damage-and-dampen-antioxidant-responses-in-bronchial-epithelial-cells
#1
Tze Khee Chan, W S Daniel Tan, Hong Yong Peh, W S Fred Wong
Exposure to environmental allergens is a major risk factor for asthma development. Allergens possess proteolytic activity that is capable of disrupting the airway epithelium. Although there is increasing evidence pointing to asthma as an epithelial disease, the underlying mechanism that drives asthma has not been fully elucidated. In this study, we investigated the direct DNA damage potential of aeroallergens on human bronchial epithelial cells and elucidated the mechanisms mediating the damage. Human bronchial epithelial cells, BEAS-2B, directly exposed to house dust mites (HDM) resulted in enhanced DNA damage, as measured by the CometChip and the staining of DNA double-strand break marker, γH2AX...
May 19, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28526624/guideline-recommendations-on-the-use-of-allergen-immunotherapy-in-house-dust-mite-allergy-time-for-a-change
#2
Moisés A Calderón, Jean Bousquet, G Walter Canonica, Lars-Olaf Cardell, Dolores Hernandez Fernandez de Rojas, Jörg Kleine-Tebbe, Pascal Demoly
Guidelines on the treatment of asthma, allergic rhinitis (AR) and allergen immunotherapy (AIT) lack recommendations for house dust mite (HDM) allergy. An expert panel reviewed current guidelines in the light of new data, to assess whether guidelines could be improved. Most guidelines and key position papers did not provide specific recommendations on treatment of allergic asthma (AA) caused by HDM allergy, although some included AIT as a treatment option for AA in general. Around half of the guidelines stated that AIT with HDM extract was an effective treatment for AR, with several indicating sublingual immunotherapy (SLIT) as an option...
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28515363/lung-cd103-dendritic-cells-restrain-allergic-airway-inflammation-through-il-12-production
#3
Laura Conejero, Sofía C Khouili, Sarai Martínez-Cano, Helena M Izquierdo, Paola Brandi, David Sancho
DCs are necessary and sufficient for induction of allergic airway inflammation. CD11b+ DCs direct the underlying Th2 immunity, but debate surrounds the function of CD103+ DCs in lung immunity and asthma after an allergic challenge. We challenged Batf3-/- mice, which lacked lung CD103+ DCs, with the relevant allergen house dust mite (HDM) as a model to ascertain their role in asthma. We show that acute and chronic HDM exposure leads to defective Th1 immunity in Batf3-deficient mice. In addition, chronic HDM challenge in Batf3-/- mice results in increased Th2 and Th17 immune responses and exacerbated airway inflammation...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28513859/identification-of-a-plasma-mirna-biomarker-signature-for-allergic-asthma-a-translational-approach
#4
Katrin Milger, Jeremias Götschke, Linda Krause, Petra Nathan, Francesca Alessandrini, Amanda Tufman, Rainald Fischer, Sabine Bartel, Fabian J Theis, Jürgen Behr, Stefan Dehmel, Nikola S Mueller, Nikolaus Kneidinger, Susanne Krauss-Etschmann
BACKGROUND: Asthma is a heterogeneous chronic disease with different phenotypes and treatment responses. Thus, there is a high clinical need for molecular disease biomarkers to aid in differentiating these distinct phenotypes. As MicroRNAs (miRNAs), that regulate gene expression at the post-transcriptional level, are altered in experimental and human asthma, circulating miRNAs are attractive candidates for the identification of novel biomarkers. This study aimed to identify plasmatic miRNA-based biomarkers of asthma, through a translational approach...
May 17, 2017: Allergy
https://www.readbyqxmd.com/read/28510479/increased-expression-of-p22phox-mediates-airway-hyperresponsiveness-in-an-experimental-model-of-asthma
#5
Chandran Nagaraj, Hans Michael Haitchi, Akos Heinemann, Peter Howarth, Andrea Olschewski, Leigh M Marsh
AIM: Chronic airway diseases such as asthma are associated with increased production of reactive oxygen species (ROS) and oxidative stress. Endogenous NADPH oxidases are a major source of superoxide in lung, but their underlying role in asthma pathology is poorly understood. We sought to characterize the involvement of NADPH oxidase in allergic asthma by studying the role of CYBA (p22phox) in human asthma and murine house dust mite (HDM)-induced allergic airway inflammation. RESULTS: Increased expression and localisation of p22-PHOX was observed in biopsies of asthmatic patients...
May 16, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28502519/-blomia-tropicalis-a-house-dust-mite-in-the-tropics
#6
REVIEW
L Guilleminault, C Viala-Gastan
INTRODUCTION: Blomia tropicalis is a mite that belongs to the superfamily of Glycyphagidae. Initially described as a storage mite, it is now considered as a house dust mite of tropical and sub-tropical areas. STATE OF THE ART: Sensitization to this mite is very common in South America and Southeast Asia. Epidemiological studies have also found sensitization to this mite in Africa and Central America. Blo t 5 is the major allergen of B. tropicalis. Co-sensitization to other house dust mites such as Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) is very common...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28500319/airway-microbial-diversity-is-inversely-associated-with-mite-sensitized-rhinitis-and-asthma-in-early-childhood
#7
Chih-Yung Chiu, Yi-Ling Chan, Yu-Shuen Tsai, Ssu-An Chen, Chia-Jung Wang, Kuan-Fu Chen, I-Fang Chung
Microbiota plays an important role in regulating immune responses associated with atopic diseases. We sought to evaluate relationships among airway microbiota, serum IgE levels, allergic sensitization and their relevance to rhinitis and asthma. Microbial characterization was performed using Illumina-based 16S rRNA gene sequencing of 87 throat swabs collected from children with asthma (n = 32) and rhinitis (n = 23), and from healthy controls (n = 32). Data analysis was performed using QIIME (Quantitative Insights Into Microbial Ecology) v1...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28497671/perceived-efficacy-and-satisfaction-of-patients-with-subcutaneous-hypoallergenic-high-dose-house-dust-mite-extract
#8
A Roger Reig, M Ibero Iborra, T Carrillo Díaz, R López Abad, V Sánchez Moreno, J Álvarez Nieto, N Cancelliere
The efficacy and safety of subcutaneous immunotherapy with modified, high-dose, major allergen house dust mite extract is widely supported by double-blind, placebo-controlled studies. However, little is known regarding patient-perceived efficacy and satisfaction. An observational, retrospective, multicentre study in patients treated with Acaroid(®) was conducted to assess the efficacy and degree of satisfaction of the patients after the first six months of treatment with it. All the clinical study procedures were performed according to the routine clinical practice...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28490399/specific-immunoglobulin-e-and-immunoglobulin-g4-toward-major-allergens-of-house-dust-mite-during-allergen-specific-immunotherapy
#9
Jianjun Chen, Yue Zhou, Yanjun Wang, Yiwu Zheng, Xuxin Lai, Emma Westermann-Clark, Seong H Cho, Weijia Kong
BACKGROUND: Specific immunoglobulin E (sIgE) and sIgG4 to house-dust mite (HDM) major allergens during allergen immunotherapy (AIT) and their clinical relevance remain unclear. OBJECTIVE: To investigate the variation of sIgE and sIgG4 to HDM major allergens and the correlation with clinical responses during AIT in patients with allergic rhinitis. METHODS: Thirty-nine patients with HDM allergy were divided into the AIT group (taking immunotherapy) and the control group (medication only use)...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28487839/changes-in-skin-reactivity-and-associated-factors-in-patients-sensitized-to-house-dust-mites-after-1-year-of-allergen-specific-immunotherapy
#10
Jeong-Yeop Son, Mann-Hong Jung, Kwang-Wook Koh, Eun-Kee Park, Jeong-Hoon Heo, Gil-Soon Choi, Hee-Kyoo Kim
BACKGROUND: Allergen-specific immunotherapy (SIT) can significantly improve symptoms and reduce the need for symptomatic medication. OBJECTIVE: The aim of this study was to investigate changes in skin reactivity to house dust mites (HDMs) as an immunologic response and associated factors after 1 year of immunotherapy. METHODS: A total of 80 patients with allergic airway diseases who received subcutaneous SIT with HDMs from 2009 to 2014 were evaluated...
April 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28487836/allergic-conjunctivitis-in-asia
#11
REVIEW
Bernard Yu-Hor Thong
Allergic conjunctivitis (AC), which may be acute or chronic, is associated with rhinitis in 30%-70% of affected individuals, hence the term allergic rhinoconjunctivitis (AR/C). Seasonal and perennial AC is generally milder than the more chronic and persistent atopic and vernal keratoconjunctivitis. Natural allergens like house dust mites (HDM), temperate and subtropical grass and tree pollen are important triggers that drive allergic inflammation in AC in the Asia-Pacific region. Climate change, environmental tobacco smoke, pollutants derived from fuel combustion, Asian dust storms originating from central/north Asia and phthalates may also exacerbate AR/C...
April 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28483732/sensitivity-to-house-dust-mites-allergens-in-patients-with-allergic-asthma-in-erzincan-province-turkey
#12
Erhan Zeytun, Salih Doğan, Fatih Özçiçek, Edhem Ünver
OBJECTIVE: To investigate the sensitivity of allergic asthma (AA) patients to house dust mites (HDM) by conducting skin tests, measuring total and specific IgE antibodies to Dermatophagoides pteronyssinus and D. farinae mites, and examining HDM fauna in patients' homes. METHODS: The study included 25 patients with AA and 31 healthy controls, who were challenged with Der p and Der f allergens; serum levels of allergen-specific lgE and total IgE were measured. Dust samples were collected from the homes of all participants, and mite species and the number of mites per gram of dust were investigated...
March 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28483562/the-role-of-inkt-cells-on-the-phenotypes-of-allergic-airways-in-a-mouse-model
#13
Lennart K A Lundblad, Nazey Gülec, Matthew E Poynter, Victoria L DeVault, Oliver Dienz, Jonathan E Boyson, Nirav Daphtary, Minara Aliyeva, Jennifer L Ather, Felix Scheuplein, Robert Schaub
iNKT cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of Th2 type cytokines and secretion of histamine and other mediators, respectively, which can promote airways hyperresponsiveness (AHR) to agents such as methacholine. However, a mechanistic link between iNKT cells and mast cell recruitment or activation has never been explored. Our objective was to determine whether iNKT cells are necessary for the recruitment of mast cells and if iNKT cells can influence the acute allergen induced bronchoconstriction (AIB) caused by mast cell mediator release...
May 5, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28483235/basophil-activation-test-for-inhalant-allergens-in-pediatric-patients-with-allergic-rhinitis
#14
Ismail Ogulur, Ayca Kiykim, Safa Baris, Ahmet Ozen, Ezgi Gizem Yuce, Elif Karakoc-Aydiner
OBJECTIVE: Flow cytometric quantification of in vitro basophil activation can be quite performant and reliable tool to measure IgE-dependent allergen-specific responses in allergic patients. Current study aimed to evaluate the clinical relevance of basophil activation test (BAT) for the diagnosis of pediatric grass pollen and house dust mite (HDM) allergies. METHODS: Forty-seven patients suffering from allergic rhinitis with HDM and grass pollen co-sensitization with clinical history of allergic rhinitis and/or asthma and 15 non-allergic healthy subjects were enrolled...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28480649/regional-difference-of-causative-pollen-in-children-with-allergic-rhinitis
#15
Myongsoon Sung, Sung Won Kim, Jeong Hee Kim, Dae Hyun Lim
The aim of this study was to investigate role of common pollen in Korean school-aged children with allergic rhinitis (AR) in 5 provinces (Incheon Metropolitan City-Gyeonggi Province, Chungcheongbuk-do, Gwangju Metropolitan City, Busan Metropolitan City, and Jeju Special Self-Governing Province), using a questionnaire and skin prick test, and to assess the differences among the residential regions. Among the enrolled 14,678 total children, 1,641 (22.0%) had AR. The sensitization rate to pollen (38.7%) was the second highest among examined allergens and significant differences were in the sensitization rates to trees, weeds, and grasses among the 5 provinces (P < 0...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28474505/house-dust-mite-specific-immunotherapy-with-two-licensed-vaccines-outcome-under-clinical-routine-conditions
#16
Vera Mahler, Christian Klein, Angelika Sager, Jürgen Zimmermann
INTRODUCTION: House dust mite (HDM) allergens are major causes for the development of allergic diseases. A disease modifying effect and clinical benefit of allergen immunotherapy (AIT) has been demonstrated in a number of clinical trials. Clinical trials, however, are carried out in selected populations under specific conditions based on inclusion and exclusion criteria and may not represent the entire patient population from medical practice. Objective of this study conducted in patients with HDM allergy was to systematically collect information about the benefit of AIT under clinical routine conditions...
June 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28473323/gabaa-receptor-%C3%AE-4-subunit-knockout-enhances-lung-inflammation-and-airway-reactivity-in-a-murine-asthma-model
#17
Gene T Yocum, Damian L Turner, Jennifer Danielsson, Matthew B Barajas, Yi Zhang, Dingbang Xu, Neil Harrison, Gregg E Homanics, Donna L Farber, Charles W Emala
Emerging evidence indicates that hypnotic anesthetics affect immune function. Many anesthetics potentiate γ-aminobutyric acid A receptor (GABAAR) activation, and these receptors are expressed on multiple subtypes of immune cells, providing a potential mechanistic link. Like immune cells, airway smooth muscle (ASM) cells also express GABAARs, particularly isoforms containing α4 subunits, and activation of these receptors leads to ASM relaxation. We sought to determine if GABAAR signaling modulates the ASM contractile and inflammatory phenotype of a murine allergic asthma model utilizing GABAAR α4 subunit global knockout (KO; Gabra4(0/0)) mice...
May 4, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28471517/the-duffy-antigen-receptor-for-chemokines-darc-regulates-asthma-pathophysiology
#18
David G Chapman, Edward B Mougey, Jos L Van der Velden, Karolyn G Lahue, Minara Aliyeva, Nirav Daphtary, Katherine L George, Sidra M Hoffman, Robert W Schneider, Russell P Tracy, George S Worthen, Matthew E Poynter, Stephen P Peters, John J Lima, Yvonne Mw Janssen-Heininger, Charles G Irvin
BACKGROUND: The Duffy Antigen Receptor for Chemokines (DARC) is an atypical receptor that regulates pro-inflammatory cytokines. However, the role of DARC in asthma pathophysiology is unknown. OBJECTIVE: To determine the role of DARC in allergic airways disease in mice, and the association between DARC single nucleotide polymorphisms (SNPs) and clinical outcomes in patients with asthma. METHODS: Mice with targeted disruption of the Darc gene (Darc(∆E2) ) or WT mice were challenged over three weeks with house dust mite (HDM) antigen...
May 4, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28461776/therapeutic-effects-of-orally-administered-cjlp55-for-atopic-dermatitis-via-the-regulation-of-immune-response
#19
Kyeong Eun Hyung, Soo Jeong Kim, Ye Won Jang, Da Kyoung Lee, Kee Hyeob Hyun, Byoung Seok Moon, Bongjoon Kim, Heeyoon Ahn, So-Young Park, Uy Dong Sohn, Eon Sub Park, Kwang Woo Hwang
Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of Lactobacillus plantarum CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered Lactobacillus strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461762/sensitization-to-aspergillus-species-is-associated-with-frequent-exacerbations-in-severe-asthma
#20
Ken Junyang Goh, Anthony Chau Ang Yii, Therese Sophie Lapperre, Adrian Kw Chan, Fook Tim Chew, Sanjay H Chotirmall, Mariko Siyue Koh
BACKGROUND: Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and asthma severity, particularly in Asia, remains unclear. We aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an Asian setting. METHODS: We conducted a cross-sectional study of patients receiving step 4 or 5 Global Initiative for Asthma treatment...
2017: Journal of Asthma and Allergy
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