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https://www.readbyqxmd.com/read/29331618/efficacy-and-safety-of-sublingual-immunotherapy-with-dermatophagoides-farinae-drops-in-pre-school-and-school-age-children-with-allergic-rhinitis
#1
L-X Tang, X-J Yang, P-P Wang, W-T Ge, J Zhang, Y-L Guo, J Lu, J Tai, Y-M Zhang, X Ni
BACKGROUND: The safety and efficacy of sublingual immunotherapy (SLIT) have been confirmed by many studies. However, in China, the research on efficacy and safety in young and older children with allergic rhinitis (AR) is still rare. OBJECTIVE: The aim of this retrospective study is to evaluate the efficacy and safety of SLIT with Dermatophagoides farinae drops in pre-school and school-age children with AR. METHODS: A total of 282 subjects aged 2-13 years with AR received a two-year course of sublingual immunotherapy along with pharmacotherapy...
January 10, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29329322/methylene-tetrahydrofolate-reductase-contributes-to-allergic-airway-disease
#2
Kenneth R Eyring, Brent S Pedersen, Kenneth N Maclean, Sally P Stabler, Ivana V Yang, David A Schwartz
RATIONALE: Environmental exposures strongly influence the development and progression of asthma. We have previously demonstrated that mice exposed to a diet enriched with methyl donors during vulnerable periods of fetal development can enhance the heritable risk of allergic airway disease through epigenetic changes. There is conflicting evidence on the role of folate (one of the primary methyl donors) in modifying allergic airway disease. OBJECTIVES: We hypothesized that blocking folate metabolism through the loss of methylene-tetrahydrofolate reductase (Mthfr) activity would reduce the allergic airway disease phenotype through epigenetic mechanisms...
2018: PloS One
https://www.readbyqxmd.com/read/29323160/glutathione-s-transferase-gst-of-american-cockroach-periplaneta-americana-classes-isoforms-and-allergenicity
#3
Nitat Sookrung, Onrapak Reamtong, Rojana Poolphol, Nitaya Indrawattana, Watee Seesuay, Nawannaporn Saelim, Pongsakorn Tantilipikorn, Chaweewan Bunnag, Wanpen Chaicumpa, Anchalee Tungtrongchitr
Insect glutathione S-transferases (GSTs) play important roles in insecticide/drug resistance and stress response. Medically, GSTs of house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis) and German cockroach (Blattella germanica) are human allergens. In this study, classes, isoforms and B-cell and allergenic epitopes of GST of American cockroach, Periplaneta americana, the predominant species in the tropics and subtropics were investigated for the first time. Enzymatically active native and recombinant P...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319884/similar-localization-of-conformational-ige-epitopes-on-the-house-dust-mite-allergens-der-p-5-and-der-p-21-despite-limited-ige-cross-reactivity
#4
M Curin, T Garmatiuk, Y Resch-Marat, K W Chen, G Hofer, K Fauland, W Keller, W Hemmer, S Vrtala, M Focke-Tejkl, R Valenta
BACKGROUND: Due to high IgE recognition frequency and high allergenic activity, Der p 5 and Der p 21 are clinically important house dust mite (HDM) allergens. The objective of this study was to characterise the immunodominant IgE epitopes of Der p 5 and Der p 21 responsible for their high allergenic activity. METHODS: A panel of 12 overlapping peptides spanning the Der p 5 and Der p 21 sequence were synthesized to search for sequential IgE epitopes by direct testing for allergic patients ' IgE reactivity...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319845/il-37-inhibits-il-4-il-13-induced-ccl11-production-and-lung-eosinophilia-in-murine-allergic-asthma
#5
Jiaoyan Lv, Yingluo Xiong, Wenjing Li, Xinyi Cui, Xunjia Cheng, Qibin Leng, Rui He
BACKGROUND: IL-37 is emerging as an anti-inflammatory cytokine, particularly in innate inflammation. However, the role of IL-37 in Th2-mediated allergic lung inflammation remains uncertain. We sought to determine the role and the underlying mechanisms of IL-37 in the development of house dust mites (HDM)-induced murine asthma model. METHODS: We examined the effect of IL-37 administration during the sensitization or challenge phase on Th2-mediated allergic asthma induced by inhaled HDM...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319193/house-dust-mite-impairs-antiviral-response-in-asthma-exacerbation-models-through-its-effects-on-tlr3
#6
Hamid Akbarshahi, Mandy Menzel, Sangeetha Ramu, Irma Mahmutovic Persson, Leif Bjermer, Lena Uller
BACKGROUND: Impaired antiviral interferon expression may be involved in asthma exacerbations commonly caused by rhinovirus infections. Allergy is a known risk factor for viral-induced asthma exacerbation, but little is known whether allergens may affect interferon responses. OBJECTIVE: Our hypothesis is that house dust mite (HDM) impairs viral stimulus-induced antiviral signalling. METHODS: Experimental asthma exacerbations were produced in vitro in human bronchial epithelial cells (HBECs) and in mice by using sequential challenges with HDM and a viral infection mimic, Poly(I:C)...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29318623/subcutaneous-immunotherapy-with-purified-der-p1-and-2-suppresses-type-2-immunity-in-a-murine-asthma-model
#7
Laura Hesse, Nienke van Ieperen, Corine Habraken, Arjen H Petersen, Silvia Korn, Tim Smilda, Betty Goedewaagen, Marcel H Ruiters, Adrianus C van der Graaf, Martijn C Nawijn
Allergen-specific immunotherapy can induce long-term suppression of allergic symptoms, reduce medication use and prevent exacerbations of allergic rhinitis and asthma. Current treatment is based on crude allergen extracts, which contain immunostimulatory components such as β-glucans, chitins and endotoxin. Use of purified or recombinant allergens might therefore increase efficacy of treatment. Here, we test application of purified natural group 1 and 2 allergens from Dermatophagoides pteronyssinus (Der p) for subcutaneous immunotherapy (SCIT) treatment in a house dust mite (HDM) driven mouse model of allergic asthma...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29318574/prophylactic-benefits-of-systemically-delivered-simvastatin-treatment-in-a-house-dust-mite-challenged-murine-model-of-allergic-asthma
#8
Aruni Jha, Min H Ryu, O O Ojo, Hilary J Bews, Jules C Carlson, Jacquie Schwartz, Sujata Basu, Charles S Wong, Andrew J Halayko
BACKGROUND AND PURPOSE: Systemically delivered statins can blunt airway inflammation in ovalbumin-challenged mice; however, in asthma clinical trials the beneficial effects of introducing oral statins are not compelling. We aim to reconcile this discrepancy using a clinically relevant murine model of allergic asthma, and by including a prophylactic study arm. EXPERIMENTAL APPROACH: Adult mice were: 1) challenged with house dust mite (HDM) alone or with subcutaneous (s...
January 10, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29315632/food-allergen-sensitized-ccr9-lymphocytes-enhance-airways-allergic-inflammation-in-mice
#9
Laure Castan, Marie-Aude Cheminant, Luc Colas, Sophie Brouard, Antoine Magnan, Grégory Bouchaud
BACKGROUND: The mechanisms of the atopic march, characterized by a natural progression from food and cutaneous allergies to rhinitis and asthma, are still unknown. However, as several organs can be involved, chemokines and their receptors might be implicated in this process and may be instrumental factors. OBJECTIVES: We hypothesized that the T-cell gut-homing receptor CCR9 could be implicated in the evolution of allergic diseases. METHODS: We characterized the immune response and the role of CCR9 in a murine model combining food allergy to wheat gliadin and a model of acute airways inflammation in response to house dust mite...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29315623/tnf-family-member-light-acts-with-il-1%C3%AE-and-tgf-%C3%AE-to-promote-airway-remodeling-during-rhinovirus-infection
#10
Amit K Mehta, Taylor Doherty, David Broide, Michael Croft
BACKGROUND: Rhinovirus (RV) can exacerbate allergen-driven asthma. However, it has been suggested that serial infections with RV may also lead to asthma-like features in childhood without prior allergen exposure. AIM: We sought to test the effects of RV infection in the absence of allergen challenge on lung tissue remodeling and to understand if RV induced factors in common with allergen that promote remodeling. METHODS: We infected C57BL/6 mice multiple times with RV in the absence or presence of allergen to assess airway remodeling...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29310755/home-environmental-interventions-for-house-dust-mite
#11
Jeffrey M Wilson, Thomas A E Platts-Mills
It has been 50 years since the dust mite was first appreciated to be a major source of allergen in house dust, and by extension a key trigger of allergic respiratory disease. Since that time a number of protein allergens have been identified and characterized, mainly from mite feces, and standardized mite extracts and IgE assays have been developed. Insights into the lifecycle of dust mites and aspects of mite allergen biology have shed light on the mechanisms that lead to respiratory disease and to the development of interventions that can minimize dust mite allergen exposure...
January 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29305916/pkc-%C3%AE-%C3%AE-regulates-th17-differentiation-and-house-dust-mite-induced-allergic-airway-inflammation
#12
Yingying Yang, Panpan Dong, Jing Zhao, Wei Zhou, Yonghua Zhou, Yongliang Xu, Congjin Mei, Fukun Guo, Yi Zheng, Jun-Qi Yang
Asthma is a chronic airway inflammation in which Th2 and Th17 cells play critical roles in its pathogenesis. We have reported that atypical protein kinase (PKC) λ/ι is a new regulator for Th2 differentiation and function. However, the role of PKCλ/ι for Th17 cells remains elusive. In this study, we explored the effect of PKCλ/ι on Th17 cells in the context of ex vivo cell culture systems and an in vivo murine model of allergic airway inflammation with the use of activated T cell-specific conditional PKCλ/ι-deficient mice...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29304132/correction-schistosoma-japonicum-infection-downregulates-house-dust-mite-induced-allergic-airway-inflammation-in-mice
#13
Sugan Qiu, Xiaolin Fan, Yingying Yang, Panpan Dong, Wei Zhou, Yongliang Xu, Yonghua Zhou, Fukun Guo, Yi Zheng, Jun-Qi Yang
[This corrects the article DOI: 10.1371/journal.pone.0179565.].
2018: PloS One
https://www.readbyqxmd.com/read/29301118/blueprint-for-the-house-dust-mite
#14
Wayne R Thomas
No abstract text is available yet for this article.
January 5, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29290503/-evaluation-of-sensitization-to-der-p-1-and-der-p-2-in-a-pediatric-population-of-the-north-of-portugal
#15
Sara Peixoto, Joana Soares, Tânia Monteiro, Marisa Carvalho, Marinela Santos, Carla Simões, Márcia Quaresma
INTRODUCTION: In Portugal, data on the role of Der p 1 and Der p 2 in patients with house dust mite (HDM) allergy are scarce. Allergen-specific immunotherapy (sIT) is the only treatment that improves symptoms, reduces the need for pharmacological therapy and modifies the natural history of the disease. With this study, the authors aim to understand the local epidemiology and to clarify if the molecular assay of major allergens is advantageous in deciding and/or modifying the decision to initiate sIT in children with clinical indication which are sensitized to Dermatophagoides pteronyssinus...
December 28, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29288652/co-activation-of-gr-and-ppar%C3%AE-in-murine-skin-prevents-worsening-of-atopic-march
#16
Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart Lambrecht, Hamida Hammad, Karolien De Bosscher
Children with atopic dermatitis (AD) show an increased risk to develop asthma later in life, a phenomenon referred to as 'atopic march', which emphasizes the need for secondary prevention therapies. This study aimed to investigate whether relief of skin inflammation by glucocorticoids and PPARγ-agonists might influence the subsequent development of asthma in a murine model for the atopic march in which mice were repeatedly exposed to house dust mite (HDM) via the skin, followed by exposure to HDM in lungs...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29281052/mite-fauna-assessment-in-houses-of-two-distinct-socioeconomic-groups-from-southern-brazil
#17
Moisés S Dutra, Cristian Roncada, Guilherme L da Silva, Noeli J Ferla, Paulo M Pitrez
House dust mites (HDM) are the main source of aeroallergens worldwide, yet epidemiological differences between socioeconomic factors in association with this medical condition have not been studied in the south region of Brazil. To assess the prevalence of HDM in two socioeconomically distinct populations of patients with allergic asthma or rhinitis, the differences between samples from houses of high-income families and low-income families were analyzed. Mite samples were collected between July and December 2015, in Porto Alegre, Brazil...
December 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29279261/flagellated-protozoa-detected-in-dermatophagoides-by-light-microscopy
#18
R Martínez-Girón
House dust mites (HDM) are arthropods of medical importance due to their relationship with allergic diseases. House dust provides a detrital habitat for these organisms, in which human skin scales are a primary food source. For digestion, wall gut cells elaborate potent proteases. Nevertheless, the observation of flagellated protozoa in intestinal extracts of HDM by light microscopy might contribute to digestive processes in mites, opening a new avenue of research regarding the ecological interactions between mites and these microorganisms in the utilisation of such substrates, as well as with regard to allergic diseases...
December 23, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29279260/scabies-crusted-norwegian-scabies-and-the-diagnosis-of-mite-sensitisation
#19
REVIEW
M Sánchez-Borges, L González-Aveledo, A Capriles-Hulett, F Caballero-Fonseca
Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE class antibodies to Sarcoptes scabiei allergens which cross-react with Dermatophagoides major allergens Der p 1 and Der p 2, positive immediate-type skin tests to house dust mite extracts should be interpreted cautiously...
December 23, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29274414/lrp-1-attenuates-house-dust-mite-induced-eosinophilic-airway-inflammation-by-suppressing-dendritic-cell-mediated-adaptive-immune-responses
#20
Amarjit Mishra, Xianglan Yao, Ankit Saxena, Elizabeth M Gordon, Maryann Kaler, Rosemarie A Cuento, Amisha V Barochia, Pradeep K Dagur, J Philip McCoy, Karen J Keeran, Kenneth R Jeffries, Xuan Qu, Zu-Xi Yu, Stewart J Levine
BACKGROUND: The LDL-receptor related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma. OBJECTIVE: To assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in house dust mite (HDM)-induced airways disease. METHODS: LRP-1 expression on peripheral blood DCs was quantified by flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with a deletion of LRP-1 in CD11c+ cells (Lrp1fl/fl; CD11c-Cre) and by the adoptive transfer of HDM-pulsed CD11b+ DCs from Lrp1fl/fl; CD11c-Cre mice to wild-type mice...
December 20, 2017: Journal of Allergy and Clinical Immunology
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