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Hiv neuropathy

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https://www.readbyqxmd.com/read/28933703/longitudinal-study-of-falls-among-hiv-infected-and-uninfected-women-the-role-of-cognition
#1
Anjali Sharma, Donald R Hoover, Qiuhu Shi, Susan Holman, Michael W Plankey, Phyllis C Tien, Kathleen M Weber, Michelle Floris-Moore, Hector H Bolivar, David E Vance, Elizabeth T Golub, Marcia McDonnell Holstad, Michael T Yin
BACKGROUND: Although fracture rates are higher in HIV+ than HIV- women, whether HIV infection increases risk of falls is unclear. We determined the longitudinal occurrence and risk factors for falls in the Women's Interagency HIV Study (WIHS), and explored associations with cognitive complaints. METHODS: Recent (prior 6 months) self-reported falls were collected in 1816 (1250 HIV+; 566 HIV-) women over 24 months. Generalized estimating equation models using stepwise selection determined odds of any fall (vs...
September 21, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28930847/guillain-barr%C3%A3-like-axonal-polyneuropathy-associated-with-toscana-virus-infection-a-case-report
#2
Eugenia Rota, Nicola Morelli, Paolo Immovilli, Paola De Mitri, Donata Guidetti
RATIONALE: Numerous cases of post-infectious Guillain-Barré syndrome (GBS) have been reported in the literature. Toscana virus (TOSV) is an arthropod-borne emerging pathogen in the Mediterranean area. PATIENT CONCERNS: A 40-year-old male patient was admitted to hospital for acute facial weakness, associated to numbness paraesthesias at lower and upper limbs. The neurological examination revealed facial diplegia and reduced tendon reflexes. The nerve conduction studies documented an acute motor and sensory axonal neuropathy (AMSAN); the lumbar puncture detected albuminocytologic dissociation...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28886173/prevalence-of-self-reported-comorbidities-in-hiv-positive-and-hiv-negative-men-who-have-sex-with-men-over-55-years-the-australian-positive-peers-longevity-evaluation-study-apples
#3
Kathy Petoumenos, Robin Huang, Jennifer Hoy, Mark Bloch, David J Templeton, David Baker, Michelle Giles, Matthew G Law, David A Cooper
In Australia, almost half of HIV-positive people are now aged over 50 and are predominately gay and bisexual men (GBM). Compared to the general HIV-negative population, GBM engage more in behaviours that may increase the risk of age-related comorbidities, including smoking, high alcohol consumption and recreational drug use. The objective of APPLES was to compare comorbidities and risk factors in HIV-positive older GBM with an appropriate control group of HIV-negative GBM. We undertook a prospectively recruited cross-sectional sample of HIV-positive and HIV-negative GBM ≥ 55 years...
2017: PloS One
https://www.readbyqxmd.com/read/28861848/update-of-hiv-associated-sensory-neuropathies
#4
REVIEW
Angela Aziz-Donnelly, Taylor B Harrison
PURPOSE OF REVIEW: HIV-sensory neuropathy (HIV-SN) remains a common complication of HIV infection and may be associated with significant morbidity due to neuropathic pain. The overall purpose of this review is to discuss trends in the changing epidemiology in HIV-SN, new data regarding the pathophysiology of the condition, and discuss approaches to management. RECENT FINDINGS: While HIV-SN has been historically considered the most common neurological complication of HIV infection, improved accessibility to effective combination antiretroviral therapy (cART), use of less neurotoxic antiretroviral medication regimens, and trends towards earlier introduction of treatment have impacted the condition: overall incident HIV-SN is likely decreased compared to prior rates and patients afflicted by HIV-SN may more frequently have asymptomatic or subclinical disease...
August 31, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28832288/is-laboratory-screening-prior-to-antiretroviral-treatment-useful-in-johannesburg-south-africa-baseline-findings-of-a-clinical-trial
#5
Willem D F Venter, Mohammed Majam, Godspower Akpomiemie, Natasha Arulappan, Michelle Moorhouse, Nonkululeko Mashabane, Matthew F Chersich
BACKGROUND: Screening for renal, hepatic and haematological disorders complicates the initiation of current first-line antiretroviral therapy (ART). Each additional test done adds substantial costs, both through direct laboratory expenses, but also by increasing the burden on health workers and patients. Evaluating the prevalence of clinically relevant abnormalities in different population groups could guide decisions about what tests to recommend in national guidelines, or in local adaptations of these...
July 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28819738/high-dose-8-capsaicin-patch-in-treatment-of-chemotherapy-induced-peripheral-neuropathy-single-center-experience
#6
Iwona Filipczak-Bryniarska, Roger M Krzyzewski, Jakub Kucharz, Anna Michalowska-Kaczmarczyk, Justyna Kleja, Jarosław Woron, Katarzyna Strzepek, Lucyna Kazior, Jerzy Wordliczek, Tomasz Grodzicki, Krzysztof Krzemieniecki
High-dose capsaicin patch is effective in treatment of neuropathic pain in HIV-associated neuropathy and diabetic neuropathy. There are no studies assessing effectiveness of high-dose capsaicin patch in treatment of chemotherapy-induced peripheral neuropathy. We sought to determine the effectiveness of treatment of pain associated with chemotherapy-induced peripheral neuropathy with high-dose capsaicin patch. Our study group consisted of 18 patients with clinically confirmed oxaliplatin-induced neuropathy. Baseline characteristic including underling disease, received cumulative dose of neurotoxic agent, neuropathic symptoms, prior treatment and initial pain level were recorded...
August 17, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28806197/frailty-is-strongly-associated-with-increased-risk-of-recurrent-falls-among-older-hiv-infected-adults-a-prospective-cohort-study
#7
Katherine Tassiopoulos, Mona Abdo, Kunling Wu, Susan L Koletar, Frank J Palella, Robert Kalayjian, Babafemi Taiwo, Kristine M Erlandson
OBJECTIVE: Both frailty and falls occur at earlier than expected ages among HIV-infected individuals, but the contribution of frailty to fall risk in this population is not well understood. We examined this association among participants enrolled in AIDS Clinical Trials Group (ACTG) A5322. DESIGN: A prospective, multi-center cohort study of HIV-infected men and women ≥40 years. METHODS: Frailty assessment included a 4-meter walk, grip strength, and self-reported weight loss, exhaustion, and low physical activity...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28800335/an-overview-of-human-immunodeficiency-virus-type-1-associated-common-neurological-complications-does-aging-pose-a-challenge
#8
Anantha Ram Nookala, Joy Mitra, Nitish S Chaudhari, Muralidhar L Hegde, Anil Kumar
With increasing survival of patients infected with human immunodeficiency virus type 1 (HIV-1), the manifestation of heterogeneous neurological complications is also increasing alarmingly in these patients. Currently, more than 30% of about 40 million HIV-1 infected people worldwide develop central nervous system (CNS)-associated dysfunction, including dementia, sensory, and motor neuropathy. Furthermore, the highly effective antiretroviral therapy has been shown to increase the prevalence of mild cognitive functions while reducing other HIV-1-associated neurological complications...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28768983/longitudinally-extensive-transverse-myelitis-and-optic-neuropathy-associated-with-syphilitic-meningomyelitis-and-human-immunodeficiency-virus-infection-a-case-report-and-review-of-the-literature
#9
Rie Tohge, Yuya Shinoto, Makio Takahashi
The incidence of co-infection with Treponema pallidum and human immunodeficiency virus (HIV) is increasing in developing and developed countries. The neurological complications of both infections occasionally occur simultaneously during a clinical course. We herein report the case of an HIV carrier with syphilitic meningomyelitis and subclinical optic neuropathy. The patient presumably had latent syphilis and slowly developed longitudinally extensive transverse myelitis (LETM). A cerebrospinal fluid examination confirmed the diagnosis of active neurosyphilis based on an elevated T...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28765048/diabetes-changes-symptoms-cluster-patterns-in-persons-living-with-hiv
#10
Julie Ann Zuniga, Eliezer Bose, Jungmin Park, M Danet Lapiz-Bluhm, Alexandra A García
Approximately 10-15% of persons living with HIV (PLWH) have a comorbid diagnosis of diabetes mellitus (DM). Both of these long-term chronic conditions are associated with high rates of symptom burden. The purpose of our study was to describe symptom patterns for PLWH with DM (PLWH+DM) using a large secondary dataset. The prevalence, burden, and bothersomeness of symptoms reported by patients in routine clinic visits during 2015 were assessed using the 20-item HIV Symptom Index. Principal component analysis was used to identify symptom clusters...
July 15, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28764704/objective-impairments-of-gait-and-balance-in-adults-living-with-hiv-1-infection-a-systematic-review-and-meta-analysis-of-observational-studies
#11
Karina Berner, Linzette Morris, Jochen Baumeister, Quinette Louw
BACKGROUND: Gait and balance deficits are reported in adults with HIV infection and are associated with reduced quality of life. Current research suggests an increased fall-incidence in this population, with fall rates among middle-aged adults with HIV approximating that in seronegative elderly populations. Gait and postural balance rely on a complex interaction of the motor system, sensory control, and cognitive function. However, due to disease progression and complications related to ongoing inflammation, these systems may be compromised in people with HIV...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28731977/interventions-for-neuropathic-pain-an-overview-of-systematic-reviews
#12
REVIEW
Svjetlana Dosenovic, Antonia Jelicic Kadic, Maja Miljanovic, Marina Biocic, Krste Boric, Marija Cavar, Nikolina Markovina, Katarina Vucic, Livia Puljak
Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials on interventions for NeuP. Five electronic databases were searched up to March 2015. Study quality was analyzed using A Measurement Tool to Assess Systematic Reviews. The most common interventions in 97 included SRs were pharmacologic (59%) and surgical (15%). The majority of analyzed SRs were of medium quality...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#13
REVIEW
Francisco Javier Carod Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
July 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28710709/psychological-factors-associated-with-painful-versus-non-painful-hiv-associated-sensory-neuropathy
#14
Prinisha Pillay, Antonia L Wadley, Catherine L Cherry, Alan S Karstaedt, Peter R Kamerman
HIV-associated sensory neuropathy (HIV-SN) is a common, and frequently painful complication of HIV, but factors that determine the presence of pain are unresolved. We investigated: (i) if psychological factors associated with painful (n = 125) versus non-painful HIV-SN (n = 72), and (ii) if pain and psychological factors affected quality of life (QoL). We assessed anxiety and depression using the Hopkins Symptoms Checklist-25. Pain catastrophizing and QoL were assessed using the Pain Catastrophizing Scale and Euroqol-5D, respectively...
July 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28679596/peripheral-neuropathy-in-hiv-infected-and-uninfected-patients-in-rakai-uganda
#15
Deanna Saylor, Gertrude Nakigozi, Noeline Nakasujja, Kevin Robertson, Ronald H Gray, Maria J Wawer, Ned Sacktor
OBJECTIVE: To determine the prevalence, risk factors, and functional impairment associated with peripheral neuropathy in a prospective cohort of adults in rural Uganda. METHODS: Eight hundred participants (400 HIV- and 400 antiretroviral-naive HIV+) in the Rakai Community Cohort Study underwent detailed neurologic evaluations including assessment of neuropathy symptoms, functional measures (Patient Assessment of Own Functioning Inventory and Karnofsky Performance Status scores), and neurologic evaluation by a trained medical officer...
August 1, 2017: Neurology
https://www.readbyqxmd.com/read/28655682/distal-sensory-polyneuropathy-among-hiv-infected-patients-at-parakou-university-hospital-benin-2011
#16
T A Adoukonou, P Kouna-Ndouongo, A Kpangon, D Gnonlonfoun, B Kpacha, A Dovonou, D Houinato
Distal sensory polyneuropathy (DSP) is the most frequent neurological complication among HIV patients, and its risk increases with use of highly active antiretroviral therapy (HAART). We aimed to assess the prevalence of DSP and the factors associated with it among HIV-infected outpatients treated at Parakou University Hospital. This cross-sectional study took place from April 15 to July 15, 2011, and included 262 patients. All patients underwent a neurological examination by two neurologists with training and clinical experience in these examinations and in the Brief Peripheral Neuropathy Screening (BPNS), which was the primary tool used here...
June 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28632471/lenalidomide-as-a-treatment-for-relapsed-al-amyloidosis-in-an-hiv-positive-patient
#17
Johanna Denman, Kaveh Manavi, Mark Cook
We present a case of an HIV-positive man with systemic immunoglobulin light chain (AL) amyloid with cardiac involvement. At relapse, he was treated with lenalidomide and dexamethasone having previously developed autonomic neuropathy with bortezomib-based chemotherapy. The patient achieved a serological complete response with symptomatic improvement. After 11 cycles, lenalidomide was discontinued due to extensive ischaemia of the gastrointestinal tract. The patient remains symptomatically stable with normal levels of serum-free light chains 11 months after the treatment was discontinued...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28594979/use-of-corneal-confocal-microscopy-to-evaluate-small-nerve-fibers-in-patients-with-human-immunodeficiency-virus
#18
Harriet I Kemp, Ioannis N Petropoulos, Andrew S C Rice, Jan Vollert, Christoph Maier, Dietrich Sturm, Marc Schargus, Tunde Peto, Scott Hau, Reena Chopra, Rayaz A Malik
Importance: Objective quantification of small fiber neuropathy in patients with human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) is difficult but needed for diagnosis and monitoring. In vivo corneal confocal microscopy (IVCCM) can quantify small fiber damage. Objective: To establish whether IVCCM can identify an abnormality in corneal nerve fibers and Langerhans cells in patients with and without HIV-SN. Design, Setting, and Participants: This prospective, cross-sectional cohort study was conducted between July 24, 2015, and September 17, 2015...
July 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28576432/anticeramide-antibody-and-butyrylcholinesterase-in-peripheral-neuropathies
#19
Aparna Sykam, V R Gutlapalli, Sandeep P Tenali, A K Meena, Priscilla Chandran, Sujai Suneetha, Lavanya M Suneetha
Ceramide is a glycosphingolipid, a component of nerve and non neuronal cell membrane and plays a role in maintaining the integrity of neuronal tissue. Butyrylcholinesterase (BChE) is a multifunctional enzyme, its involvement in neurodegenerative diseases has been well established. Anticeramide antibody (Ab-Cer) and enzyme BChE have been implicated in peripheral neuropathies. The present study investigates whether there is an association between Ab-Cer and BChE activities and peripheral neuropathies. Patients included: human immunodeficiency virus associated peripheral neuropathy (HIV-PN, n=39), paucibacillary leprosy (PB-L, n=36), multibacillary leprosy (MB-L, n=52), diabetic neuropathy (DN, n=22), demyelinating sensory motor polyneuropathy (DSMN, n=13) and chronic inflammatory demyelinating polyneuropathy (CIDP, n=10)...
August 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28561925/evolution-of-sensory-neuropathy-after-initiation-of-antiretroviral-therapy
#20
Chad M Centner, Francesca Little, Johan J van der Watt, John-Randel Vermaak, Joel A Dave, Naomi S Levitt, Jeannine M Heckmann
INTRODUCTION: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in HIV-infected South Africans. METHODS: Enrolment commenced before ART with 6-monthly follow-up for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as one symptom and sign. Symptom/sign scores were compared between visits. RESULTS: We enrolled 184 participants. Pre-ART, 16% had SDSP. After 18 months of ART, pain prevalence decreased in those with pre-ART SDSP (odds ratio [OR] 0...
May 31, 2017: Muscle & Nerve
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