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https://www.readbyqxmd.com/read/29223121/from-information-to-participation-and-self-organization-visions-for-european-river-basin-management
#1
Johannes Euler, Sonja Heldt
The European Union Water Framework Directive (EU WFD, 2000) calls for active inclusion of the public in the governance of waterbodies to enhance the effectiveness and legitimacy of water management schemes across the EU. As complex socio-ecological systems, river basins in western Europe could benefit from further support for inclusive management schemes. This paper makes use of case studies from Germany, England and Spain to explore the potential opportunities and challenges of different participatory management approaches...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29222973/utilisation-of-academic-nursing-competence-in-europe-a-survey-among-members-of-the-european-academy-of-nursing-science
#2
Tove Aminda Hanssen, Pia Riis Olsen
BACKGROUND: In line with national and international strategies in Europe, the number of nurses with a doctoral degree has increased. The European Academy of Nursing Science (EANS) has for 18years delivered a three-year doctoral summer school for nurses. Questions have been raised in terms of how academic nurses' competencies are used and in what positions. AIM: To understand the progression of nurses' academic careers following completion of the EANS Summer School and to picture how research and academic skills of the nurses are being used for research and/or other fields in nursing...
November 23, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29222922/survival-of-children-after-liver-transplantation-for-hepatocellular-carcinoma
#3
Ulrich Baumann, René Adam, Christophe Duvoux, Rafael Mikolajczyk, Vincent Karam, Lorenzo D'Antiga, Christophe Chardot, Ahmet Coker, Michele Colledan, Bo-Goran Erizon, Pål Dag Line, Nedim Hadzic, Helena Isoniemi, Jürgen L Klempnauer, Raymond Reding, Patrick J McKiernan, Valérie McLin, Andreas Paul, Mauro Salizzoni, Emanuel San Bento Furtado, Stefan Schneeberger, André Karch
Hepatocellular carcinoma (HCC) in childhood differs from adult HCC as it is often associated with inherited liver disease. It is, however, unclear whether liver transplantation (LT) for HCC in childhood with or without associated inherited disease has a comparable outcome to adult HCC. Based on data from the European Liver Transplant Registry (ELTR) we aimed to investigate if there are differences in patient and graft survival after LT for HCC between children and adults and between patients with underlying inherited versus non inherited liver disease respectively...
December 9, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29222675/accuracy-of-computed-tomography-for-selecting-the-revascularization-method-based-on-syntax-score-ii
#4
Si Eun Lee, Kyunghwa Han, Jin Hur, Young Jin Kim, Hye-Jeong Lee, Yoo Jin Hong, Dong Jin Im, Byoung Wook Choi
OBJECTIVES: The application of SYNTAX score II based on coronary CT angiography (CCTA) for selecting further treatment options has not been studied. This study aimed to investigate the diagnostic performance of CCTA combined with SYNTAX score II for selecting the revascularization method compared with invasive coronary angiography (ICA) based on 2014 European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) guidelines. METHODS: From January-May 2011, 160 patients who underwent both CCTA and ICA within 30 interval days were included...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29222667/drug-burden-and-its-association-with-falls-among-older-adults-in-new-zealand-a-national-population-cross-sectional-study
#5
Hamish A Jamieson, Prasad S Nishtala, Richard Scrase, Joanne M Deely, Rebecca Abey-Nesbit, Martin J Connolly, Sarah N Hilmer, Darrell R Abernethy, Philip J Schluter
BACKGROUND: Adverse outcomes associated with advanced diseases are often exacerbated by polypharmacy. OBJECTIVES: The current study investigated an association between exposure to anticholinergic and sedative medicines and falls in community-dwelling older people, after controlling for potential confounders. METHODS: We conducted a retrospective cross-sectional study of a continuously recruited national cohort of community-dwelling New Zealanders aged 65 years and over...
December 8, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29222665/small-but-diverse-larval-trematode-communities-in-the-small-freshwater-planorbids-gyraulus-albus-and-segmentina-nitida-gastropoda-pulmonata-from-the-ruhr-river-germany
#6
J Schwelm, M Soldánová, T Vyhlídalová, B Sures, C Selbach
In contrast to the well-studied trematode fauna of lymnaeid snails, only little is known about the role of small planorbid snails as first intermediate hosts for trematodes in temperate freshwater systems. This study aims at closing this gap by assessing the diversity and composition of larval trematode communities in Gyraulus albus and Segmentina nitida in a Central European reservoir system, and by providing an updated comprehensive review of the published trematode records of these snail hosts. A total of 3691 planorbid snails (3270 G...
December 8, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29222464/the-irish-dna-atlas-revealing-fine-scale-population-structure-and-history-within-ireland
#7
Edmund Gilbert, Seamus O'Reilly, Michael Merrigan, Darren McGettigan, Anne M Molloy, Lawrence C Brody, Walter Bodmer, Katarzyna Hutnik, Sean Ennis, Daniel J Lawson, James F Wilson, Gianpiero L Cavalleri
The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations. Here we illustrate fine-scale genetic structure across Ireland that follows geographic boundaries and present evidence of admixture events into Ireland. Utilising the 'Irish DNA Atlas', a cohort (n = 194) of Irish individuals with four generations of ancestry linked to specific regions in Ireland, in combination with 2,039 individuals from the Peoples of the British Isles dataset, we show that the Irish population can be divided in 10 distinct geographically stratified genetic clusters; seven of 'Gaelic' Irish ancestry, and three of shared Irish-British ancestry...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222339/the-biological-variation-data-critical-appraisal-checklist-a-standard-for-evaluating-studies-on-biological-variation
#8
Aasne K Aarsand, Thomas R Raas, Pilar Fernandez-Calle, Carmen Ricos, Jorge Díaz-Garzón, Niels Jonker, Carmen Perich, Elisabet González-Lao, Anna Carobene, Joana Minchinela, Abdurrahman Coŝkun, Margarita Simón, Virtudes Álvarez, William A Bartlett, Pilar Fernández-Fernández, Beatriz Boned, Federica Braga, Zoraida Corte, Berna Aslan, Sverre Sandberg
BACKGROUND: Concern has been raised about the quality of available biological variation (BV) estimates and the effect of their application in clinical practice. A European Federation of Clinical Chemistry and Laboratory Medicine Task and Finish Group has addressed this issue. The aim of this report is to (a) describe the Biological Variation Data Critical Appraisal Checklist (BIVAC), which verifies whether publications have included all essential elements that may impact the veracity of associated BV estimates, (b) use the BIVAC to critically appraise existing BV publications on enzymes, lipids, kidney, and diabetes-related measurands, and (c) apply metaanalysis to deliver a global within-subject BV (CVI) estimate for alanine aminotransferase (ALT)...
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29222052/in-vitro-co-culture-models-to-evaluate-acute-cytotoxicity-of-individual-and-combined-mycotoxin-exposures-on-caco-2-thp-1-and-heparg-human-cell-lines
#9
Marie-Caroline Smith, Alexiane Gheux, Monika Coton, Stéphanie Madec, Nolwenn Hymery, Emmanuel Coton
Deoxynivalenol (DON) and zearalenone (ZEA) are mycotoxins primarily produced by Fusarium species and commonly co-occur in European grains. Some in vitro studies reported synergistic combined effects on cell viability reduction for these two natural food contaminants. However, most of these studies were carried out on conventional cell culture systems involving only one cell type and thus, did not accurately reflect in vivo conditions, including cell-cell communication. In this context, we developed easy bi- and tri-culture systems using the Caco-2 (intestinal epithelial cells), THP-1 (monocytes) and HepaRG (hepatocytes) human cell lines...
December 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29222034/management-of-invasive-candidiasis-and-candidemia-in-critically-ill-adults-expert-opinion-of-the-european-society-of-anaesthesia-esa-intensive-care-scientific-subcommittee
#10
REVIEW
Ruth-Aoibheann OLeary, Sharon Einav, Marc Leone, Krisztina Madách, Claude Martin, Ignacio Martin-Loeches
OBJECTIVE: The global burden of invasive fungal disease is increasing. Candida albicans remains the leading cause of fungal blood stream infections although non-albicans Candidal infections are emerging. Areas of controversy regarding diagnosis and management are hampering our ability to respond effectively to this evolving threat. The purpose of this narrative review is to address current controversies and provide recommendations to supplement guidelines. DIAGNOSIS OF INVASIVE CANDIDIASIS: Diagnosis of invasive candidiasis requires a combination of diagnostic tests and patient risk factors...
December 5, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29221872/proposal-of-concentration-limits-for-determining-the-hazard-property-hp-14-for-waste-using-ecotoxicological-tests
#11
Pierre Hennebert
Different ecotoxicological test batteries and concentration limits have been proposed to assess the hazard property (HP) HP 14 'Ecotoxic' for waste in the European Union and its member states. In test batteries, if the concentration of waste in the culture/dilution medium producing 50% of inhibitory biological effect in one or more test(s) is below the concentration limit of the test, the waste is classified as hazardous. A summarized review of the test batteries proposed since 1998 is presented. The last proposed test battery uses seven aquatic and terrestrial species with standardized methods, but with options and uniform concentration limits of 10% of waste eluate or solid waste in the culture/dilution medium...
December 5, 2017: Waste Management
https://www.readbyqxmd.com/read/29221862/physical-activity-sedentary-time-tv-viewing-physical-fitness-and-cardiovascular-disease-risk-in-adolescents-the-helena-study
#12
Alan R Barker, Luis Gracia-Marco, Jonatan R Ruiz, Manuel J Castillo, Raquel Aparicio-Ugarriza, Marcela González-Gross, Anthony Kafatos, Odysseas Androutsos, Angela Polito, Dénes Molnar, Kurt Widhalm, Luis A Moreno
BACKGROUND: To examine the independent associations between physical activity (PA) intensities, sedentary time (ST), TV viewing, cardiorespiratory fitness (CRF) and muscular fitness (MF) with cardiovascular disease (CVD) risk in youth. METHODS: A cross-sectional study on 534 European adolescents (252 males, 282 females, 12.5-17.5years). Minutes per day of light (LPA), moderate (MPA) and vigorous (VPA) PA and total ST were measured using accelerometers. TV viewing time was measured using a questionnaire...
November 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29221494/factors-associated-with-the-achievement-of-cervical-smears-by-general-practitioners
#13
Michaël Rochoy, Thibaut Raginel, Jonathan Favre, Estelle Soueres, Nassir Messaadi, Valérie Deken, Alain Duhamel, Christophe Berkhout
OBJECTIVE: Reliable data about general practitioners performing pap-tests are insufficient. A claim code for the achievement of pap-smears exists in France, but its use by general practitioners is not known. The main purpose of this study was to highlight independent factors associated with the achievement of pap-smears by the general practitioner (GP). We carried out a descriptive and analytic epidemiologic study in 347 GPs and their 244,889 patients, registered at the Health Care Insurance Fund of Flanders...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29221444/genome-wide-association-study-of-coronary-artery-calcified-atherosclerotic-plaque-in-african-americans-with-type-2-diabetes
#14
Jasmin Divers, Nicholette D Palmer, Carl D Langefeld, W Mark Brown, Lingyi Lu, Pamela J Hicks, S Carrie Smith, Jianzhao Xu, James G Terry, Thomas C Register, Lynne E Wagenknecht, John S Parks, Lijun Ma, Gary C Chan, Sarah G Buxbaum, Adolfo Correa, Solomon Musani, James G Wilson, Herman A Taylor, Donald W Bowden, John Jeffrey Carr, Barry I Freedman
BACKGROUND: Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC, and when they do, have markedly lower levels than European Americans. Genetic factors likely contribute to the observed ethnic differences. To identify genes associated with CAC in AAs with type 2 diabetes (T2D), a genome-wide association study (GWAS) was performed using the Illumina 5 M chip in 691 African American-Diabetes Heart Study participants (AA-DHS), with replication in 205 Jackson Heart Study (JHS) participants with T2D...
December 8, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29221331/five-reasons-for-caution-in-advocating-low-dose-computerized-tomographic-lung-cancer-screening
#15
Jerome M Reich, Jong S Kim
The 53.5K-person, low-dose computerized tomographic (LDCT), National Lung Cancer Screening Trial (NLST) achieved a 20% reduction in lung cancer mortality and a 6.7% reduction in all-cause mortality at 6.5-year median follow-up. Failure of European LDCT trials employing null (i.e., unscreened) controls to reproduce this benefit compels caution in adopting a policy of population screening. Additional concerns merit attention: surgical mortality is not trivial; overdiagnosis is substantial; disease-free life expectancy and quality of life are markedly diminished by loss of pulmonary reserve; the combination of overdiagnosis and diminished disease-free life expectancy is pernicious...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221149/prediction-on-the-risk-population-of-idiosyncratic-adverse-reactions-based-on-molecular-docking-with-mutant-proteins
#16
Hongbo Xie, Diheng Zeng, Xiujie Chen, Diwei Huo, Lei Liu, Denan Zhang, Qing Jin, Kehui Ke, Ming Hu
Idiosyncratic adverse drug reactions are drug reactions that occur rarely and unpredictably among the population. These reactions often occur after a drug is marketed, which means that they are strongly related to the genotype of the population. The prediction of such adverse reactions is a major challenge because of the lack of appropriate test models during the drug development process. In this study, we chose withdrawn drugs because the reasons why they were withdrawn and from which countries or regions is easily obtained...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220884/a-black-swan-in-clinical-laboratory-practice-the-analytical-error-due-to-interferences-in-immunoassay-methods
#17
Aldo Clerico, Lucia Belloni, Cinzia Carrozza, Mario Correale, Ruggero Dittadi, Claudio Dotti, Antonio Fortunato, Giulio Vignati, Gian Carlo Zucchelli, Marco Migliardi
It is well known that the results of immunoassay methods can be affected by specific or non-specific interferences, ranging from 0.4% to 4.0%. The presence of interference may greatly compromise the accuracy of immunoassay analyses causing an error in the measurement, producing false-positive or false-negative results. From a clinical point of view, these analytical errors may have serious implications for patient care because they can cause misdiagnosis or inappropriate treatment. Unfortunately, it is a very difficult task to identify the irregular analytical errors related to immunoassay methods because they are not detectable by normal laboratory quality control procedures, are reproducible within the test system, may be clinically plausible and are relatively rare...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29220861/do-we-need-plant-food-supplements-a-critical-examination-of-quality-safety-efficacy-and-necessity-for-a-new-regulatory-framework
#18
Mona Abdel-Tawab
Given the expanding market of plant food supplements (PFSs) not undergoing any pre-marketing authorization, the overall quality, safety and efficacy of PFSs were subjected to a critical examination. Although many high-quality PFSs exist on the legal market, quality concerns are in general justified. Besides economic adulteration, active ingredients dramatically differing from label claims and among products were reported in several studies. In addition, PFSs sold via the Internet may be intentionally adulterated with undeclared prescription drugs...
December 8, 2017: Planta Medica
https://www.readbyqxmd.com/read/29220717/microbial-electricity-driven-anoxic-ammonium-removal
#19
Anna Vilajeliu-Pons, Christin Koch, Maria D Balaguer, Jesús Colprim, Falk Harnisch, Sebastià Puig
Removal of nitrogen, mainly in form of ammonium (NH4+), in wastewater treatment plants (WWTPs) is a highly energy demanding process, mainly due to aeration. It causes costs of about half a million Euros per year in an average European WWTP. Alternative, more economical technologies for the removal of nitrogen compounds from wastewater are required. This study proves the complete anoxic conversion of ammonium (NH4+) to dinitrogen gas (N2) in continuously operated bioelectrochemical systems at the litre-scale...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29220676/penetrance-of-polygenic-obesity-susceptibility-loci-across-the-body-mass-index-distribution
#20
Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C Engert, Salim Yusuf, Hertzel C Gerstein, Sonia S Anand, David Meyre
A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression (MR) models. The effects of nine SNPs (24%)-rs1421085 (FTO; p = 8.69 × 10-15), rs6235 (PCSK1; p = 7...
December 7, 2017: American Journal of Human Genetics
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