Javier González-Peñas, Clara Alloza, Rachel Brouwer, Covadonga M Díaz-Caneja, Javier Costas, Noemí González-Lois, Ana Guil Gallego, Lucía de Hoyos, Xaquín Gurriarán, Álvaro Andreu-Bernabeu, Rafael Romero-García, Lourdes Fañanas, Julio Bobes, Ana González Pinto, Benedicto Crespo-Facorro, Lourdes Martorell, Manuel Arrojo, Elisabet Vilella, Alfonso Guitiérrez-Zotes, Marta Perez-Rando, María Dolores Moltó, Elizabeth Buimer, Neeltje van Haren, Wiepke Cahn, Michael O'Donovan, René S Kahn, Celso Arango, Hilleke Hulshoff Pol, Joost Janssen, Hugo Schnack
BACKGROUND: Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the lifespan. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified. METHODS: We conducted linear mixed models to estimate the rates of accelerated cortical thinning across 68 regions from the Desikan-Killiany atlas in individuals with schizophrenia compared to healthy controls from a large longitudinal sample (NCases = 169 and NControls = 298, aged 16-70 years)...
March 21, 2024: Biological Psychiatry