keyword
https://read.qxmd.com/read/38529370/erratum-pertinence-of-glioma-and-single-nucleotide-polymorphism-of-tert-ccdc26-cdkn2a-b-and-rtel1-genes-in-glioma-a-meta-analysis
#21
(no author information available yet)
[This corrects the article DOI: 10.3389/fonc.2023.1180099.].
2024: Frontiers in Oncology
https://read.qxmd.com/read/38529286/novel-prognostic-biomarker-tbc1d1-is-associated-with-immunotherapy-resistance-in-gliomas
#22
JOURNAL ARTICLE
Daqiang Song, Qian Yang, Liuying Li, Yuxian Wei, Chong Zhang, Huimin Du, Guosheng Ren, Hongzhong Li
BACKGROUND: Glioma, an aggressive brain tumor, poses a challenge in understanding the mechanisms of treatment resistance, despite promising results from immunotherapy. METHODS: We identified genes associated with immunotherapy resistance through an analysis of The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Gene Expression Omnibus (GEO) databases. Subsequently, qRT-PCR and western blot analyses were conducted to measure the mRNA and protein levels of TBC1 Domain Family Member 1 (TBC1D1), respectively...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38528608/chronic-hypoxia-remodels-the-tumor-microenvironment-to-support-glioma-stem-cell-growth
#23
JOURNAL ARTICLE
J G Nicholson, S Cirigliano, R Singhania, C Haywood, M Shahidi Dadras, M Yoshimura, D Vanderbilt, B Liechty, H A Fine
Cerebral organoids co-cultured with patient derived glioma stem cells (GLICOs) are an experimentally tractable research tool useful for investigating the role of the human brain tumor microenvironment in glioblastoma. Here we describe long-term GLICOs, a novel model in which COs are grown from embryonic stem cell cultures containing low levels of GSCs and tumor development is monitored over extended durations (ltGLICOs). Single-cell profiling of ltGLICOs revealed an unexpectedly long latency period prior to GSC expansion, and that normal organoid development was unimpaired by the presence of low numbers of GSCs...
March 25, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38528135/ultra-high-b-value-dwi-accurately-identifies-isocitrate-dehydrogenase-genotypes-and-tumor-subtypes-of-adult-type-diffuse-gliomas
#24
JOURNAL ARTICLE
Xueqin Wang, Xinru Shu, Pingping He, Yiting Cai, Yingqian Geng, Xiaomei Hu, Yifan Sun, Huinan Xiao, Wanyi Zheng, Yang Song, Yunjing Xue, Rifeng Jiang
OBJECTIVES: To distinguish isocitrate dehydrogenase (IDH) genotypes and tumor subtypes of adult-type diffuse gliomas based on the fifth edition of the World Health Organization classification of central nervous system tumors (WHO CNS5) in 2021 using standard, high, and ultra-high b-value diffusion-weighted imaging (DWI). MATERIALS AND METHODS: This prospective study enrolled 70 patients with adult-type diffuse gliomas who underwent multiple b-value DWI. Apparent diffusion coefficient (ADC) values including ADCb500/b1000 , ADCb500/b2000 , ADCb500/b3000 , ADCb500/b4000 , ADCb500/b6000 , ADCb500/b8000 , and ADCb500/b10000 in tumor parenchyma (TP) and contralateral normal-appearing white matter (NAWM) were calculated...
March 25, 2024: European Radiology
https://read.qxmd.com/read/38527238/bergaptol-inhibits-glioma-cell-proliferation-and-induces-apoptosis-via-stat3-bcl-2-pathway
#25
JOURNAL ARTICLE
Hao Huang, Junrong Zhang, Jianbing Wu, Chunfu Du, Bo Zheng, Zhangchao Guo, Ligang Chen, Deming Zhang, Luotong Liu
Glioblastoma (GBM) is the most common primary malignant brain tumour and lacks therapeutic options with significant effects. The aberrant activation of STAT3 is a critical factor in glioma progression via activating multiple signalling pathways that promote glioma. Among them, the antiapoptotic gene Bcl-2 could be upregulated by p-STAT3, which is an important reason for the continuous proliferation of glioma. We previously reported that bergaptol, a natural furanocoumarin widely found in citrus products, exerts antineuroinflammatory effects by inhibiting the overactivation of STAT3...
March 22, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38526307/brain-delivery-of-biomimetic-phosphorus-dendrimer-antibody-nanocomplexes-for-enhanced-glioma-immunotherapy-via-immune-modulation-of-t-cells-and-natural-killer-cells
#26
JOURNAL ARTICLE
Yamin Peng, Mengsi Zhan, Andrii Karpus, Yu Zou, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi, Mingwu Shen
Fully mobilizing the activities of multiple immune cells is crucial to achieve the desired tumor immunotherapeutic efficacy yet still remains challenging. Herein, we report a nanomedicine formulation based on phosphorus dendrimer (termed AK128)/programmed cell death protein 1 antibody (aPD1) nanocomplexes (NCs) that are camouflaged with M1-type macrophage cell membranes (M1m) for enhanced immunotherapy of orthotopic glioma. The constructed AK128-aPD1@M1m NCs with a mean particle size of 160.3 nm possess good stability and cytocompatibility...
March 25, 2024: ACS Nano
https://read.qxmd.com/read/38525424/therapeutically-targeting-the-unique-disease-landscape-of-pediatric-high-grade-gliomas
#27
REVIEW
Dasun Fernando, Afsar U Ahmed, Bryan R G Williams
Pediatric high-grade gliomas (pHGG) are a rare yet devastating malignancy of the central nervous system's glial support cells, affecting children, adolescents, and young adults. Tumors of the central nervous system account for the leading cause of pediatric mortality of which high-grade gliomas present a significantly grim prognosis. While the past few decades have seen many pediatric cancers experiencing significant improvements in overall survival, the prospect of survival for patients diagnosed with pHGGs has conversely remained unchanged...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38523840/myeloid-cells-as-potential-targets-for-immunotherapy-in-pediatric-gliomas
#28
REVIEW
Stephen C Frederico, Nikhil Sharma, Corbin Darling, Suchet Taori, Alexandra C Dubinsky, Xiaoran Zhang, Itay Raphael, Gary Kohanbash
Pediatric high-grade glioma (pHGG) including pediatric glioblastoma (pGBM) are highly aggressive pediatric central nervous system (CNS) malignancies. pGBM comprises approximately 3% of all pediatric CNS malignancies and has a 5-year survival rate of approximately 20%. Surgical resection and chemoradiation are often the standard of care for pGBM and pHGG, however, even with these interventions, survival for children diagnosed with pGBM and pHGG remains poor. Due to shortcomings associated with the standard of care, many efforts have been made to create novel immunotherapeutic approaches targeted to these malignancies...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38523682/csf-findings-in-chinese-patients-with-nmdar-lgi1-and-gababr-antibody-associated-encephalitis
#29
JOURNAL ARTICLE
Shan Qiao, Haiyun Li, Caisan Cui, Chong Zhang, Aihua Wang, Wenjing Jiang, Shanchao Zhang
PURPOSE: CSF inflammation in subtypes of antibody-defined autoimmune encephalitis (AE) ranges in intensity from moderate to severe. In a retrospective, cross-sectional study, we characterized CSF findings in Chinese patients with anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E), anti-leucine-rich glioma-inactivated 1 encephalitis (LGI1-E), and anti-gamma aminobutyric acid-B receptor encephalitis (GABABR-E). PATIENTS AND METHODS: The AE cases, including 102 NMDAR-E, 68 LGI1-E and 15 GABABR-E, were included...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38523681/coactosin-like-protein-1-cotl1-could-be-an-immunological-and-prognostic-biomarker-from-pan-cancer-analysis-to-low-grade-glioma-validation
#30
JOURNAL ARTICLE
Xiaoyun Wang, Yuwei Bai, Bei Wang
BACKGROUND: Cancer represents a widespread global health challenge impacting millions of individuals worldwide. Identifying new targets for cancer treatment is a crucial step in developing more effective therapies. Among these potential targets, Coactosin-like protein 1 (COTL1), a cytoskeleton-associated protein with critical roles in cell migration, adhesion, and signaling, has shown involvement in tumor progression. METHODS: GSCA, TIMER, SangerBox database were used to explore the COTL1 expression across different tumor types...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38523150/fe-3-o-4-chitosan-zif-8-rvg29-an-anti-glioma-nanoplatform-guided-by-fixed-and-activated-by-alternating-magnetic-field
#31
JOURNAL ARTICLE
Mohammad-Nabil Savari
There is considerable interest in developing anti-glioma nanoplatforms. They make the all-in-one combination of therapies possible. Here we show how the selective Glioblastoma multiforme (GBM) cell killing of the here-established nanoplatforms increased after each coating and how the here-established vibration-inducing Alternating magnetic field (AMF) decreased the treatment time from 72 h to 30 s. Thanks to their magnetite core, these nanoplatforms can be guided to the tumor's specific site by a Fixed magnetic field, they bypass the Blood-Brain Barrier (BBB) and accumulate at the tumor site thanks to the RVG29 bonding to the G-protein on the ion-gated channel receptor known as the nicotinic acetylcholine receptor (nAchR), which expresses on BBB cells and overexpresses on GBM cells, and thanks to the positive charge gained by both chitosan and RVG29's peptide...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38522817/extracellular-vesicles-derived-from-dendritic-cells-loaded-with-vegf-a-sirna-and-doxorubicin-reduce-glioma-angiogenesis-in-vitro
#32
JOURNAL ARTICLE
Parisa Shamshiripour, Mehrana Rahnama, Mehdi Nikoobakht, Vahideh Farzam Rad, Ali-Reza Moradi, Davoud Ahmadvand
BACKGROUND: Numerous attempts have been devoted to designing anti-angiogenic agents as a strategy to slow tumor growth and progression. Clinical applications of conventional anti-angiogenic agents face some challenges, e.g., off-target effects for TKIs and also low solid tumor penetration for mAbs. Furthermore, although anti-angiogenic therapy provides a normalization window for better chemo-RT response, in long-term treatments, tumor hypoxia as a result of total removal of VEGF-A by mAbs from the TME or complete blockade of TK receptors induces over-activation of compensatory angiogenic pathways, causing escape...
March 22, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38522697/harnessing-the-potential-of-nanoengineered-sirnas-carriers-for-target-responsive-glioma-therapy-recent-progress-and-future-opportunities
#33
REVIEW
Kailash Ahirwar, Ankit Kumar, Nidhi Srivastava, Shubhini A Saraf, Rahul Shukla
Past scientific testimonials in the field of glioma research, the deadliest tumor among all brain cancer types with the life span of 10-15 months after diagnosis is considered as glioblastoma multiforme (GBM). Even though the availability of treatment options such as chemotherapy, radiotherapy, and surgery, are unable to completely cure GBM due to tumor microenvironment complexity, intrinsic cellular signalling, and genetic mutations which are involved in chemoresistance. The blood-brain barrier is accountable for restricting drugs entry at the tumor location and related biological challenges like endocytic degradation, short systemic circulation, and insufficient cellular penetration lead to tumor aggression and progression...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521933/a-systematic-review-of-high-impact-cpg-sites-and-regions-for-mgmt-methylation-in-glioblastoma-a-systematic-review-of-mgmt-methylation-in-gbm
#34
JOURNAL ARTICLE
David Gibson, Anh Huan Vo, Hannah Lambing, Prithanjan Bhattacharya, Peggy Tahir, Farid F Chehab, Nicholas Butowski
BACKGROUND: MGMT (O 6 -methylguanine-DNA methyltransferase) promoter methylation is a commonly assessed prognostic marker in glioblastoma (GBM). Epigenetic silencing of the MGMT gene by promoter methylation is associated with greater overall and progression free survival with alkylating agent regimens. To date, there is marked heterogeneity in how MGMT promoter methylation is tested and which CpG sites are interrogated. METHODS: To further elucidate which MGMT promoter CpG sites are of greatest interest, we performed comprehensive searches in PubMed, Web of Science, and Embase and reviewed 2,925 article abstracts...
March 23, 2024: BMC Neurology
https://read.qxmd.com/read/38521679/cortico-cortical-evoked-potentials-of-language-tracts-in-minimally-invasive-glioma-surgery-guided-by-penfield-stimulation
#35
JOURNAL ARTICLE
Kathleen Seidel, Jonathan Wermelinger, Pablo Alvarez-Abut, Vedran Deletis, Andreas Raabe, David Zhang, Philippe Schucht
OBJECTIVE: We investigated the feasibility of recording cortico-cortical evoked potentials (CCEPs) in patients with low- and high-grade glioma. We compared CCEPs during awake and asleep surgery, as well as those stimulated from the functional Broca area and recorded from the functional Wernicke area (BtW), and vice versa (WtB). We also analyzed CCEP properties according to tumor location, histopathology, and aphasia. METHODS: We included 20 patients who underwent minimally invasive surgery in an asleep-awake-asleep setting...
March 5, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/38521619/retraction-notice-to-amentoflavone-suppresses-cell-proliferation-and-induces-cell-death-through-triggering-autophagy-dependent-ferroptosis-in-human-glioma-life-sci-247-2020-117425
#36
Yan Chen, Ning Li, Haijing Wang, Ningning Wang, Hui Peng, Jing Wang, Yihong Li, Mingdi Liu, Hui Li, Yu Zhang, Zhaohui Wang
No abstract text is available yet for this article.
March 23, 2024: Life Sciences
https://read.qxmd.com/read/38520726/bacteria-synergized-with-pd-1-blockade-enhance-positive-feedback-loop-of-cancer-cells-m1-macrophages-t-cells-in-glioma
#37
JOURNAL ARTICLE
Qi Chen, Yuyi Zheng, Xiaojie Chen, Yuan Xing, Jiajie Zhang, Xinyi Yan, Qi Zhang, Di Wu, Zhong Chen
Cancer immunotherapy is an attractive strategy because it stimulates immune cells to target malignant cells by regulating the intrinsic activity of the immune system. However, due to lacking many immunologic markers, it remains difficult to treat glioma, a representative "cold" tumor. Herein, to wake the "hot" tumor immunity of glioma, Porphyromonas gingivalis (Pg) is customized with a coating to create an immunogenic tumor microenvironment and further prove the effect in combination with the immune checkpoint agent anti-PD-1, exhibiting elevated therapeutic efficacy...
March 23, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38520537/stereotactic-frame-based-biopsy-of-infratentorial-lesions-via-the-suboccipital-transcerebellar-approach-with-the-zamorano-duchovny-stereotactic-system-a-retrospective-analysis-of-79-consecutive-cases
#38
JOURNAL ARTICLE
Manuel Kaes, Christopher Beynon, Karl Kiening, Jan-Oliver Neumann, Martin Jakobs
OBJECTIVE: Lesions of the posterior fossa (brainstem and cerebellum) are challenging in diagnosis and treatment due to the fact that they are often located eloquently and total resection is rarely possible. Therefore, frame-based stereotactic biopsies are commonly used to asservate tissue for neuropathological diagnosis and further treatment determination. The aim of our study was to assess the safety and diagnostic success rate of frame-based stereotactic biopsies for lesions in the posterior fossa via the suboccipital-transcerebellar approach...
March 23, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38520250/risk-factors-for-glioblastoma-are-shared-by-other-brain-tumor-types
#39
JOURNAL ARTICLE
Carr J Smith, Thomas A Perfetti, Chirayu Chokshi, Chitra Venugopal, J Wesson Ashford, Sheila K Singh
The reported risk factors for glioblastoma (GBM), i.e., ionizing radiation, Li-Fraumeni syndrome, Neurofibromatosis I, and Turcot syndrome, also increase the risk of other brain tumor types. Risk factors for human GBM are associated with different oncogenic mutation profiles. Pedigreed domestic dogs with a shorter nose and flatter face (brachycephalic dogs) display relatively high rates of glioma formation. The genetic profiles of canine gliomas are also idiosyncratic. The association of putatively different mutational patterns in humans and canines with GBM suggests that different oncogenic pathways can result in GBM formation...
2024: Human & Experimental Toxicology
https://read.qxmd.com/read/38519889/cd13-expression-affects-glioma-patient-survival-and-influences-key-functions-of-human-glioblastoma-cell-lines-in-vitro
#40
JOURNAL ARTICLE
Wenying Zhang, Anne Blank, Irina Kremenetskaia, Anja Nitzsche, Güliz Acker, Peter Vajkoczy, Susan Brandenburg
CD13 (APN) is an Alanyl-Aminopeptidase with diverse functions. The role of CD13 for gliomas is still unknown. In this study, data of glioma patients obtained by TCGA and CGGA databases were used to evaluate the survival rate and prognostic value of CD13 expression level. Protein expression of CD13 was confirmed by immunofluorescence staining of fresh patient tissues. Eight human glioblastoma cell lines were studied by RT-PCR, Western Blot, immunofluorescence staining and flow cytometry to define CD13 expression...
March 22, 2024: BMC Cancer
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