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https://www.readbyqxmd.com/read/28894357/advances-in-the-delivery-of-buprenorphine-for-opioid-dependence
#1
REVIEW
Richard N Rosenthal, Viral V Goradia
Opioid use disorders (OUDs) have long been a global problem, but the prevalence rates have increased over 20 years to epidemic proportions in the US, with concomitant increases in morbidity and all-cause mortality, but especially opioid overdose. These increases are in part attributable to a several-fold expansion in the prescription of opioid pain medications over the same time period. Opioid detoxification and psychosocial treatments alone have each not yielded sufficient efficacy for OUD, but μ-opioid receptor agonist, partial agonist, and antagonist medications have demonstrated the greatest overall benefit in OUD treatment...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28797120/medication-eluting-devices-for-the-field-of-obgyn-medobgyn-3d-printed-biodegradable-hormone-eluting-constructs-a-proof-of-concept-study
#2
Karthik Tappa, Udayabhanu Jammalamadaka, David H Ballard, Todd Bruno, Marissa R Israel, Harika Vemula, J Mark Meacham, David K Mills, Pamela K Woodard, Jeffery A Weisman
3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using polycaprolactone (PCL) biodegradable polymer laden with estrogen or progesterone and were subjected to hormone-release profile studies using ELISA kits. Material thermal properties were tested using thermogravimetric analysis and differential scanning calorimetry...
2017: PloS One
https://www.readbyqxmd.com/read/28796678/socioeconomic-status-as-a-risk-factor-for-unintended-pregnancy-in-the-contraceptive-choice-project
#3
Abigail Iseyemi, Qiuhong Zhao, Colleen McNicholas, Jeffrey F Peipert
OBJECTIVE: To evaluate the association of low socioeconomic status as an independent risk factor for unintended pregnancy. METHODS: We performed a secondary analysis of data from the Contraceptive CHOICE project. Between 2007 and 2011, 9,256 participants were recruited and followed for up to 3 years. The primary outcome of interest was unintended pregnancy; the primary exposure variable was low socioeconomic status, defined as self-report of either receiving public assistance or having difficulty paying for basic necessities...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28781503/probuphine-buprenorphine-subdermal-implants-for-the-treatment-of-opioid-dependent-patients
#4
Lillian Smith, Juan Mosley, Jasmine Johnson, Monica Nasri
Probuphine (buprenorphine) subdermal implants for the treatment of opioid-dependent patients.
August 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28666796/etonogestrel-contraceptive-implant-associated-secondary-anorgasmia-case-report-permissions-the-patient-provided-written-consent-for-the-reporting-of-this-case
#5
Hector O Chapa, Alexiya Ramirez, Daniel Dawson
The etonogestrel contraceptive implant is a four cm radio-opaque, subdermal rod, inserted in the non-dominant arm, providing up to three years of continuous contraception. We describe a 21year old nulligravid, non-depressed female who experienced new onset secondary anorgasmia one month after etonorgestrel insertion. Off-label, oral use of bupropion and sildenafil did not restore orgasmic ability. Finally, one week after implant removal (four and a half months after insertion), spontaneous return of orgasmic ability occurred...
June 27, 2017: Contraception
https://www.readbyqxmd.com/read/28605952/migration-of-contraceptive-implant-into-the-left-pulmonary-arterial-system
#6
Ee Phui Kew, Eshan Senanayake, Madava Djearaman, Ehab Bishay
An 18-year-old woman had an etonogestrel implant inserted into her left upper arm 2 years earlier for menorrhagia. Her symptoms were not well controlled and she requested the implant to be removed. However, clinicians were unable to locate the implant on her left arm. Computed tomography showed that the implant had migrated to a sub-lobar branch of the left lower lobe pulmonary artery. The long-term effect of leaving an etonogestrel implant in the pulmonary arterial system is unknown. This report adds to the small body of evidence on intravascular migration of a subdermally placed contraceptive implant...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28604141/cost-effectiveness-of-subdermal-implantable-buprenorphine-versus-sublingual-buprenorphine-to-treat-opioid-use-disorder
#7
John A Carter, Ryan Dammerman, Michael Frost
AIMS: Subdermal implantable buprenorphine (BSI) was recently approved to treat opioid use disorder (OUD) in clinically-stable adults. In the pivotal clinical trial, BSI was associated with a higher proportion of completely-abstinent patients (85.7% vs 71.9%; p = .03) vs sublingual buprenorphine (SL-BPN). Elsewhere, relapse to illicit drug use is associated with diminished treatment outcomes and increased costs. This study evaluated the cost-effectiveness of BSI vs SL-BPN from a US societal perspective...
June 22, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28594755/contraception-insurance-coverage-and-receipt-of-long-acting-reversible-contraception-or-depot-medroxyprogesterone-acetate-on-the-day-of-abortion
#8
Jamie W Krashin, Gretchen S Stuart, Joanne Garrett, Hannah Spector, Amy G Bryant, Samantha Charm, Jessica E Morse
OBJECTIVE: To evaluate whether contraceptive insurance coverage for women who present for an abortion is associated with obtaining long-acting reversible contraception or depot medroxyprogesterone acetate (DMPA) on the day the abortion is completed. METHODS: We conducted a prospective cohort study of women presenting for medical or surgical abortion at a single health center in North Carolina. Eligible women were 18 years or older and fluent in English or Spanish...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28583591/difficult-removal-of-subdermal-contraceptive-implants-a-multidisciplinary-approach-involving-a-peripheral-nerve-expert
#9
Elizabeth B Odom, David L Eisenberg, Ida K Fox
OBJECTIVES: We aim to describe our experiences and identify patients who may benefit from referral to a peripheral nerve surgeon for removal of contraceptive subdermal implants in which neurovascular injury may occur, and describe a treatment pathway for optimal care. STUDY DESIGN: We reviewed the charts of 22 patients who were referred to the Division of Family Planning for difficult removal of etonogestrel contraceptive implants between January 1, 2014, and April, 1 2016...
August 2017: Contraception
https://www.readbyqxmd.com/read/28567091/effect-of-rosuvastatin-on-bovine-pericardial-aortic-tissue-valve-calcification-in-a-rat-subdermal-implantation-model
#10
Seung Hyun Lee, Dae-Hyun Kim, Young-Nam Youn, Sak Lee, Hyun Chel Joo, Byung Chul Chang, Kyung-Jong Yoo
BACKGROUND AND OBJECTIVES: There are pathophysiologic similarities between calcification and atherosclerosis because both are the product of an active inflammatory process. The aim of this study was to examine the effects of statin treatment on calcification in bovine pericardial tissue valves. MATERIALS AND METHODS: Forty Sprague-Dawley rats were randomly divided into 4 groups according to hypercholesterolemia induction and statin intake (Group 1, n=10: normal diet without statin treatment, Group 2, n=10: normal diet with statin treatment, Group 3, n=10: high fat diet without statin treatment, Group 4, n=10: high fat diet with statin treatment)...
May 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28546740/new-developments-in-managing-opioid-addiction-impact-of-a-subdermal-buprenorphine-implant
#11
REVIEW
MariaLisa Itzoe, Michael Guarnieri
Opioid addiction to prescription and illicit drugs is a serious and growing problem. In the US alone, >2.4 million people suffer from opioid use disorder. Government and pharmaceutical agencies have begun to address this crisis with recently released and revised task forces and medication-assisted therapies (MAT). For decades, oral or intravenous (IV) MATs have helped patients in their recovery by administration of opioid agonists (methadone, buprenorphine, oxycodone), antagonists (naltrexone, naloxone), and combinations of the two (buprenorphine/naloxone)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28534019/migration-of-a-contraceptive-subdermal-device-into-the-lung
#12
Ji Hui Choi, Ha-Yeon Kim, Sung Soo Lee, SiHyun Cho
A single-rod subdermal contraceptive implant is usually located around the insertion site, has been usually known to migrate within less than 2 cm of the insertion site and the true migration over 2 cm has been rarely reported. We report a case of migrated radiopaque subdermal contraceptive implant into lung in a 37-year-old woman. On conducted chest computed tomography, subdermal contraceptive implant was in subsegmental branch in left posterior basal segment of lung. Removal of subdermal contraceptive implant in left posterior basal segment of lung by mini-thoracotomy was performed by a chest surgeon...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28530033/concomitant-contraceptive-implant-and-efavirenz-use-in-women-living-with-hiv-perspectives-on-current-evidence-and-policy-implications-for-family-planning-and-hiv-treatment-guidelines
#13
REVIEW
Rena C Patel, Chelsea Morroni, Kimberly K Scarsi, Tabitha Sripipatana, James Kiarie, Craig R Cohen
INTRODUCTION: Preventing unintended pregnancies is important among all women, including those living with HIV. Increasing numbers of women, including HIV-positive women, choose progestin-containing subdermal implants, which are one of the most effective forms of contraception. However, drug-drug interactions between contraceptive hormones and efavirenz-based antiretroviral therapy (ART) may reduce implant effectiveness. We present four inter-related perspectives on this issue. DISCUSSION: First, as a case study, we discuss how limited data prompted country-level guidance against the use of implants among women concomitantly using efavirenz in South Africa and its subsequent negative effects on the use of implants in general...
May 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28432718/long-acting-reversible-contraception-conflicting-perspectives-of-advocates-and-potential-users
#14
S Rowlands, R Ingham
No abstract text is available yet for this article.
September 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28348732/probuphine%C3%A2-buprenorphine-implant-a-promising-candidate-in-opioid-dependence
#15
REVIEW
Preeti Barnwal, Saibal Das, Somnath Mondal, Anand Ramasamy, Tanay Maiti, Arunava Saha
Opioid dependence leads to physical dependence and addiction which finally results in profound medical, psychological and social dysfunction. One of the useful medications for opioid dependence is buprenorphine, the partial opioid agonist, which is used alone or in combination with naloxone. However, buprenorphine is the victim of its own success due to its illicit use and accidental poisoning in children. Also, buprenorphine typically requires daily self-administration and its effectiveness heavily depends on patient adherence...
March 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28293782/baha-implant-as-a-hearing-solution-for-single-sided-deafness-after-retrosigmoid-approach-for-the-vestibular-schwannoma-surgical-results
#16
Jan Boucek, Jan Vokral, Libor Cerny, Martin Chovanec, Jiří Skrivan, Eduard Zverina, Jan Betka, Michal Zabrodsky
Skull base tumors and, in particular, vestibular schwannoma (VS) are among the etiological reasons for single-sided deafness (SSD). Patients with SSD have problems in understanding speech in a noisy environment and cannot localize the direction of sounds. Baha is one of the most frequently used systems for SSD compensation. Out of 38 patients with SSD after retrosigmoid removal of VS who underwent testing with Baha softband, 16 were satisfied and were indicated for Baha implantation. Two surgical approaches have been used-the Nijmegen linear incision technique with subdermal thinning (Group I, implant BI300) and fast surgery technique without subdermal thinning (Group II, implant BIA400)...
March 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28238839/postpartum-weight-loss-in-overweight-and-obese-women-using-the-etonogestrel-subdermal-implant-a-pilot-study
#17
Leanne Griffin, Cassing Hammond, Dachao Liu, Alfred W Rademaker, Jessica Kiley
OBJECTIVE: To compare weight loss during the first 6months postpartum in overweight and obese women using the etonogestrel implant, placed in the immediate postpartum period, with that of controls using nonhormonal contraception, utilizing a pilot design. STUDY DESIGN: Pilot, prospective cohort study. Analysis groups were divided by body mass index (overweight: 25-29.9kg/m(2); Class I Obesity: 30-34.5kg/m(2); Class II Obesity: 35-39.9kg/m(2)) and grouped by use of etonogestrel implant or nonhormonal contraception for all outcomes...
June 2017: Contraception
https://www.readbyqxmd.com/read/28223914/decoding-lower-limb-muscle-activity-and-kinematics-from-cortical-neural-spike-trains-during-monkey-performing-stand-and-squat-movements
#18
Xuan Ma, Chaolin Ma, Jian Huang, Peng Zhang, Jiang Xu, Jiping He
Extensive literatures have shown approaches for decoding upper limb kinematics or muscle activity using multichannel cortical spike recordings toward brain machine interface (BMI) applications. However, similar topics regarding lower limb remain relatively scarce. We previously reported a system for training monkeys to perform visually guided stand and squat tasks. The current study, as a follow-up extension, investigates whether lower limb kinematics and muscle activity characterized by electromyography (EMG) signals during monkey performing stand/squat movements can be accurately decoded from neural spike trains in primary motor cortex (M1)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28219567/contraceptive-implant-embolism-into-the-pulmonary-artery-thoracoscopic-retrieval
#19
Pascal A Thomas, Donatella Di Stefano, Cécile Couteau, Xavier Benoît D'Journo
An 18-year old woman had migration of a subdermal contraceptive implant in a subsegmental branch of her left lower lobe pulmonary artery. She was managed successfully through a conservative surgical approach, as the implant was removed from the pulmonary artery thoracoscopically, thereby avoiding the need of thoracotomy or lung resection.
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28207637/the-efficacy-of-a-prevascularized-retrievable-poly-d-l-lactide-co-%C3%AE%C2%B5-caprolactone-subcutaneous-scaffold-as-transplantation-site-for-pancreatic-islets
#20
Alexandra M Smink, Shiri Li, Don T Hertsig, Bart J de Haan, Leendert Schwab, Aart A van Apeldoorn, Eelco de Koning, Marijke M Faas, Jonathan R T Lakey, Paul de Vos
BACKGROUND: The liver as transplantation site for human pancreatic islets is a harsh microenvironment for islets and it lacks the ability to retrieve the graft. A retrievable, extrahepatic transplantation site that mimics the pancreatic environment is desired. Ideally, this transplantation site should be located subdermal for easy surgical-access but this never resulted in normoglycemia. Here, we describe the design and efficacy of a novel prevascularized, subcutaneously implanted, retrievable poly (D,L-lactide-co-ε-caprolactone) scaffold...
April 2017: Transplantation
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