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Subdermal implant

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https://www.readbyqxmd.com/read/28207637/the-efficacy-of-a-prevascularized-retrievable-poly-d-l-lactide-co-%C3%AE%C2%B5-caprolactone-subcutaneous-scaffold-as-transplantation-site-for-pancreatic-islets
#1
Alexandra M Smink, Shiri Li, Don T Hertsig, Bart J de Haan, Leendert Schwab, Aart A van Apeldoorn, Eelco de Koning, Marijke M Faas, Jonathan R T Lakey, Paul de Vos
BACKGROUND: The liver as transplantation site for human pancreatic islets is a harsh microenvironment for islets and it lacks the ability to retrieve the graft. A retrievable, extrahepatic transplantation site that mimics the pancreatic environment is desired. Ideally this transplantation site should be located subdermal for easy surgical-access but this never resulted in normoglycemia. Here we describe the design and efficacy of a novel prevascularized, subcutaneously implanted, retrievable poly (D,L-lactide-co-ε-caprolactone) (PDLLCL) scaffold...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28187506/the-effect-of-gene-variants-on-levonorgestrel-pharmacokinetics-when-combined-with-antiretroviral-therapy-containing-efavirenz-or-nevirapine
#2
M Neary, M Lamorde, A Olagunju, K M Darin, C Merry, P Byakika-Kibwika, D J Back, M Siccardi, A Owen, K K Scarsi
Reduced levonorgestrel concentrations from the levonorgestrel contraceptive implant was previously seen when given concomitantly with efavirenz. We sought to assess whether single nucleotide polymorphisms (SNPs) in genes involved in efavirenz and nevirapine metabolism were linked to these changes in levonorgestrel concentration. SNPs in CYP2B6, CYP2A6, NR1I2 and NR1I3 were analysed. Associations of participant demographics and genotype with levonorgestrel pharmacokinetics were evaluated in HIV-positive women using the levonorgestrel implant plus efavirenz- or nevirapine-based ART, in comparison to ART-naïve women using multivariate linear regression...
February 10, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28163088/risk-of-luteal-phase-pregnancy-with-any-cycle-day-initiation-of-subdermal-contraceptive-implants
#3
Molly Richards, Stephanie B Teal, Jeanelle Sheeder
OBJECTIVES: To determine rates of luteal phase pregnancy (LPP) in young women initiating subdermal implants on any day of the menstrual cycle. STUDY DESIGN: We assessed a retrospective cohort of young women receiving contraceptive implants at an adolescent Title-X clinic. Patients with negative pregnancy tests were eligible for same-day insertion, regardless of cycle day, contraceptive use, or last intercourse. We computed LPP rates for those within manufacturer guidelines for insertion (≤5 days of menstrual onset or ≤7 days post-discontinuing hormonal contraception) and outside these guidelines...
February 2, 2017: Contraception
https://www.readbyqxmd.com/read/28147241/prolonged-use-of-the-etonogestrel-implant-and-levonorgestrel-intrauterine-device-two-years-beyond-fda-approved-duration
#4
Colleen McNicholas, Erin Swor, Leping Wan, Jeffrey F Peipert
BACKGROUND: The subdermal contraceptive implant, and the 52mg levonorgestrel intrauterine device (IUD) are currently FDA-approved for three and five years of use respectively. Limited available data has suggested both of these methods are effective beyond that time. Demonstration of prolonged effectiveness will improve the cost-effectiveness of the device, and potentially patient continuation and satisfaction. OBJECTIVE: To evaluate the effectiveness of the contraceptive implant and the 52-mg hormonal intrauterine device (IUD) in women using the method for two years beyond the current FDA-approved duration...
January 29, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28132830/flexible-near-field-wireless-optoelectronics-as-subdermal-implants-for-broad-applications-in-optogenetics
#5
Gunchul Shin, Adrian M Gomez, Ream Al-Hasani, Yu Ra Jeong, Jeonghyun Kim, Zhaoqian Xie, Anthony Banks, Seung Min Lee, Sang Youn Han, Chul Jong Yoo, Jong-Lam Lee, Seung Hee Lee, Jonas Kurniawan, Jacob Tureb, Zhongzhu Guo, Jangyeol Yoon, Sung-Il Park, Sang Yun Bang, Yoonho Nam, Marie C Walicki, Vijay K Samineni, Aaron D Mickle, Kunhyuk Lee, Seung Yun Heo, Jordan G McCall, Taisong Pan, Liang Wang, Xue Feng, Tae-Il Kim, Jong Kyu Kim, Yuhang Li, Yonggang Huang, Robert W Gereau, Jeong Sook Ha, Michael R Bruchas, John A Rogers
In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wireless options offer important capabilities that avoid some of these limitations, but the current size, bulk, weight, and wireless area of coverage is often disadvantageous. Here, we present a simple but powerful setup based on wireless, near-field power transfer and miniaturized, thin, flexible optoelectronic implants, for complete optical control in a variety of behavioral paradigms...
February 8, 2017: Neuron
https://www.readbyqxmd.com/read/28113913/low-power-8-channel-eeg-recorder-and-seizure-detector-asic-for-a-subdermal-implantable-system
#6
Bruno G Do Valle, Sydney S Cash, Charles G Sodini
EEG remains the mainstay test for the diagnosis and treatment of patients with epilepsy. Unfortunately, ambulatory EEG systems are far from ideal for patients who have infrequent seizures. These systems only last up to 3 days and if a seizure is not captured during the recordings, a definite diagnosis of the patient's condition cannot be given. This work aims to address this need by proposing a subdermal implantable, eight-channel EEG recorder and seizure detector that has two modes of operation: diagnosis and seizure counting...
April 20, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28076528/the-brief-life-of-norplant%C3%A2-in-brazil-controversies-and-reassemblages-between-science-society-and-state
#7
Ana Cristina de Lima Pimentel, Cláudia Bonan Jannotti, Paula Gaudenzi, Luiz Antonio da Silva Teixeira
Norplant® is the brand name of the world's first registered subdermal hormonal contraceptive implant, developed by the laboratories of the Population Council, an international organisation working in the area of fertility and population growth. The article revisits the trajectory of this contraceptive in Brazil from its arrival through clinical trials to its eventual ban in 1986 by the Brazilian regulatory agency responsible for approving medications at the time. Its circulation generated controversies related to research practices, side effects and political uses of the drug as a birth control method...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28018878/regulatory-approval-time-for-hormonal-contraception-in-canada-the-united-states-and-the-united-kingdom-2000-2015-a-retrospective-data-analysis
#8
Christine Troskie, Judith A Soon, Arianne Y Albert, Wendy V Norman
BACKGROUND: Access to a wide range of contraceptive methods improves prevention of unintended pregnancy by ensuring the best method fit for each individual. We compared approval times of new hormonal contraceptives by Health Canada, the US Food and Drug Administration (FDA), and the UK Medicines and Healthcare Products Regulatory Agency (MHRA). METHODS: We obtained dates of applications to Health Canada, the FDA and the MHRA for contraceptive methods approved from January 2000 to January 2015...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/27988268/unscheduled-vaginal-bleeding-with-progestin-only-contraceptive-use
#9
REVIEW
Rachel E Zigler, Colleen McNicholas
Nearly 20% of women using contraception are using progestin-only contraception, including progestin-only pills, depot-medroxyprogesterone acetate, subdermal etonogestrel implants, and levonorgestrel intrauterine devices. This number will continue to grow with the increased provision of long-acting reversible contraception. Although overall satisfaction among women using progestin-only contraception is high, dissatisfaction and discontinuation may be associated with unscheduled bleeding and spotting. The exact etiology of irregular bleeding associated with progestin-containing contraceptives is not completely understood, yet several mechanisms have been suggested...
December 14, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27975010/reconstruction-of-the-ptotic-breast-using-wise-pattern-skin-deepithelialization
#10
Michael K Newman
Reconstruction of ptotic or large breasts is challenging due to skin redundancy after skin-sparing mastectomy. Skin reduction can be performed with a long horizontal ellipse, but this often flattens the breast and leaves conspicuous scars medially on the chest. Wise pattern skin reduction is an effective technique for shaping, but excision of skin within the Wise pattern can lead to high rates of skin necrosis and implant exposure or infection. This study describes a technique where the Wise pattern skin is preserved, but deepithelialized, allowing apparent reduction of the skin with preservation of the subdermal plexus...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27965269/safety-and-efficacy-of-the-subdermal-etonogestrel-contraceptive-implant-implanon%C3%A2
#11
Rob Beerthuizen
No abstract text is available yet for this article.
December 13, 2016: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/27957807/sequential-hydrophile-and-lipophile-solubilization-as-an-efficient-method-for-decellularization-of-porcine-aortic-valve-leaflets-structure-mechanical-property-and-biocompatibility-study
#12
Wei-Hua Qiao, Peng Liu, Dan Hu, Mahmoud Al Shirbini, Xian-Ming Zhou, Nian-Guo Dong
Antigenicity of xenogeneic tissues is the major obstacle to increased utilization of these materials in clinical medicine. Residual xenoantigens in decellularized tissue elicit the immune response after implantation, causing graft failure. With this in mind, we proposed the potential use of three protein solubilization-based protocols for porcine aortic valve leaflets decellularization. We demonstrated that hydrophile solubilization alone (HSA) achieved incomplete decellularization; lipophile solubilization alone (LSA) completely removed all cells and two most critical xenoantigens, galactose-α(1,3)-galactose (α-Gal) and major histocompatibility complex I (MHC I), but caused severe alterations of the structure and mechanical properties; sequential hydrophile and lipophile solubilization (SHLS) resulted in a complete removal of cells, α-Gal and MHC I, and a well preservation of the structure and mechanical properties; in contrast, a previously reported method using Triton X-100, sodium deoxycholate and IGEPAL CA-630 (TSI) resulted in a complete removal of all cells and MHC I, but with remaining α-Gal epitope...
December 13, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27908210/the-sexuological-impact-of-hormonal-contraceptives-based-on-their-route-of-administration
#13
Maurizio Guida, Costantino Di Carlo, Jacopo Troisi, Alessandra Gallo, Francesca Cibarelli, Ellis Martini, Lara Tiranini, Rossella E Nappi
Evidence on the effects of hormonal contraceptives on female sexuality is conflicting. We enrolled 556 women, divided into six groups: two composed of subjects using a combined hormonal contraceptive (COC) containing 0.020 ("COC20") and 0.030 ("COC30") mg of ethynyl estradiol (EE), "natural", using COC containing 1.5 mg of estradiol (E2), "ring", using a vaginal ring releasing each day 0.015 mg of EE + 0.120 of etonogestrel, "subcutaneous", using a progestin only subcutaneous contraceptive implant releasing etonogestrel and "controls", using no hormonal contraceptive methods...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27889093/removal-of-a-contraceptive-implant-from-the-brachial-neurovascular-sheath
#14
Christopher Belyea, Justin Ernat, Rey Gumboc
Subdermal implantable devices are commonly used for long-acting contraception in the United States and Europe. Although relatively safe in nature, their implantation and removal may be associated with potential complications, some of which may require surgical intervention. Complications may include infection, incorrect implantation, migration, or difficulty with removal. Proximal migration has been reported; however, there are no reports of devices that have migrated within the brachial neurovascular sheath...
February 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27888047/looking-for-a-lost-subdermal-contraceptive-implant-think-about-the-pulmonary-artery
#15
A Gallon, M Fontarensky, C Chauffour, L Boyer, P Chabrot
This case highlights a rare but potentially life-threatening complication of a contraceptive implant insertion that was corrected by a noninvasive endovascular procedure. This procedure requires a quick intervention to be successful.
February 2017: Contraception
https://www.readbyqxmd.com/read/27865875/axillary-migration-of-nexplanon%C3%A2-case-report
#16
Daniela Diego, Erryn Tappy, Jose Carugno
A 19-year-old patient presented to the clinic, and we inserted a single rod subdermal etonogestrel implant (Nexplanon ®), which subsequently migrated to the ipsilateral axilla. Distant Nexplanon® migration is a rare serious complication that should be considered when a device is nonpalpable. Management options are discussed.
February 2017: Contraception
https://www.readbyqxmd.com/read/27836601/generation-of-electrical-power-under-human-skin-by-subdermal-solar-cell-arrays-for-implantable-bioelectronic-devices
#17
Kwangsun Song, Jung Hyun Han, Hyung Chae Yang, Kwang Il Nam, Jongho Lee
Medical electronic implants can significantly improve people's health and quality of life. These implants are typically powered by batteries, which usually have a finite lifetime and therefore must be replaced periodically using surgical procedures. Recently, subdermal solar cells that can generate electricity by absorbing light transmitted through skin have been proposed as a sustainable electricity source to power medical electronic implants in bodies. However, the results to date have been obtained with animal models...
November 3, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27833514/haematological-and-biochemical-effects-of-etonogestrel-subdermal-implant-implanon-in-ilorin-nigeria
#18
Olayinka R Balogun, Abiodun S Adeniran, Adebayo A Adewole
OBJECTIVES: To evaluate the effect of etonogestrel subdermal implant (Implanon) on haematological and biochemical parameters of its users. METHODOLOGY: A prospective observational study among healthy women using Implanon for contraception. The study site was the family planning clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Informed consent was obtained and participants were followed up for three years. Follow up parameters were haematological and biochemical evaluation at insertion (baseline), first and third years post-insertion...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27773713/reassessing-the-importance-of-long-acting-contraception
#19
Quentin C Karpilow, Adam T Thomas
BACKGROUND: Several recent studies have highlighted the need for greater use of long-acting contraception. The most influential of these studies is the Contraceptive CHOICE Project, which was credited with substantially reducing participants' pregnancy risk by increasing their use of long-acting methods such as intrauterine devices and subdermal implants. However, because participants' rates of nonuse and condom use fell to zero at the outset of the intervention, it is possible that sizable pregnancy reductions could still have been achieved if enrollees had chosen shorter-acting, female-controlled methods such as oral contraception...
October 20, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27725164/tamoxifen-for-the-treatment-of-breakthrough-bleeding-with-the-etonogestrel-implant-a-randomized-controlled-trial
#20
Katharine B Simmons, Alison B Edelman, Rongwei Fu, Jeffrey T Jensen
OBJECTIVE: The etonogestrel (ENG) subdermal implant can cause frequent breakthrough bleeding in some users. The objective of this study was to evaluate whether a short course of tamoxifen reduces bleeding/spotting days compared to placebo in ENG implant users. STUDY DESIGN: In this double-blind trial, we randomized ENG implant users with frequent or prolonged bleeding or spotting to tamoxifen 10 mg or placebo twice daily for 7 days, to be started after 3 consecutive days of bleeding/spotting...
October 8, 2016: Contraception
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