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https://www.readbyqxmd.com/read/28076528/the-brief-life-of-norplant%C3%A2-in-brazil-controversies-and-reassemblages-between-science-society-and-state
#1
Ana Cristina de Lima Pimentel, Cláudia Bonan Jannotti, Paula Gaudenzi, Luiz Antonio da Silva Teixeira
Norplant® is the brand name of the world's first registered subdermal hormonal contraceptive implant, developed by the laboratories of the Population Council, an international organisation working in the area of fertility and population growth. The article revisits the trajectory of this contraceptive in Brazil from its arrival through clinical trials to its eventual ban in 1986 by the Brazilian regulatory agency responsible for approving medications at the time. Its circulation generated controversies related to research practices, side effects and political uses of the drug as a birth control method...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28018878/regulatory-approval-time-for-hormonal-contraception-in-canada-the-united-states-and-the-united-kingdom-2000-2015-a-retrospective-data-analysis
#2
Christine Troskie, Judith A Soon, Arianne Y Albert, Wendy V Norman
BACKGROUND: Access to a wide range of contraceptive methods improves prevention of unintended pregnancy by ensuring the best method fit for each individual. We compared approval times of new hormonal contraceptives by Health Canada, the US Food and Drug Administration (FDA), and the UK Medicines and Healthcare Products Regulatory Agency (MHRA). METHODS: We obtained dates of applications to Health Canada, the FDA and the MHRA for contraceptive methods approved from January 2000 to January 2015...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/27988268/unscheduled-vaginal-bleeding-with-progestin-only-contraceptive-use
#3
REVIEW
Rachel E Zigler, Colleen McNicholas
Nearly 20% of women using contraception are using progestin-only contraception, including progestin-only pills, depot-medroxyprogesterone acetate, subdermal etonogestrel implants, and levonorgestrel intrauterine devices. This number will continue to grow with the increased provision of long-acting reversible contraception. Although overall satisfaction among women using progestin-only contraception is high, dissatisfaction and discontinuation may be associated with unscheduled bleeding and spotting. The exact etiology of irregular bleeding associated with progestin-containing contraceptives is not completely understood, yet several mechanisms have been suggested...
December 14, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27975010/reconstruction-of-the-ptotic-breast-using-wise-pattern-skin-deepithelialization
#4
Michael K Newman
Reconstruction of ptotic or large breasts is challenging due to skin redundancy after skin-sparing mastectomy. Skin reduction can be performed with a long horizontal ellipse, but this often flattens the breast and leaves conspicuous scars medially on the chest. Wise pattern skin reduction is an effective technique for shaping, but excision of skin within the Wise pattern can lead to high rates of skin necrosis and implant exposure or infection. This study describes a technique where the Wise pattern skin is preserved, but deepithelialized, allowing apparent reduction of the skin with preservation of the subdermal plexus...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27965269/safety-and-efficacy-of-the-subdermal-etonogestrel-contraceptive-implant-implanon%C3%A2
#5
Rob Beerthuizen
No abstract text is available yet for this article.
December 13, 2016: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/27957807/sequential-hydrophile-and-lipophile-solubilization-as-an-efficient-method-for-decellularization-of-porcine-aortic-valve-leaflets-structure-mechanical-property-and-biocompatibility-study
#6
Wei-Hua Qiao, Peng Liu, Dan Hu, Mahmoud Al Shirbini, Xian-Ming Zhou, Nian-Guo Dong
Antigenicity of xenogeneic tissues is the major obstacle to increased utilization of these materials in clinical medicine. Residual xenoantigens in decellularized tissue elicit the immune response after implantation, causing graft failure. With this in mind, we proposed the potential use of three protein solubilization-based protocols for porcine aortic valve leaflets decellularization. We demonstrated that hydrophile solubilization alone (HSA) achieved incomplete decellularization; lipophile solubilization alone (LSA) completely removed all cells and two most critical xenoantigens, galactose-α(1,3)-galactose (α-Gal) and major histocompatibility complex I (MHC I), but caused severe alterations of the structure and mechanical properties; sequential hydrophile and lipophile solubilization (SHLS) resulted in a complete removal of cells, α-Gal and MHC I, and a well preservation of the structure and mechanical properties; in contrast, a previously reported method using Triton X-100, sodium deoxycholate and IGEPAL CA-630 (TSI) resulted in a complete removal of all cells and MHC I, but with remaining α-Gal epitope...
December 13, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27908210/the-sexuological-impact-of-hormonal-contraceptives-based-on-their-route-of-administration
#7
Maurizio Guida, Costantino Di Carlo, Jacopo Troisi, Alessandra Gallo, Francesca Cibarelli, Ellis Martini, Lara Tiranini, Rossella E Nappi
Evidence on the effects of hormonal contraceptives on female sexuality is conflicting. We enrolled 556 women, divided into six groups: two composed of subjects using a combined hormonal contraceptive (COC) containing 0.020 ("COC20") and 0.030 ("COC30") mg of ethynyl estradiol (EE), "natural", using COC containing 1.5 mg of estradiol (E2), "ring", using a vaginal ring releasing each day 0.015 mg of EE + 0.120 of etonogestrel, "subcutaneous", using a progestin only subcutaneous contraceptive implant releasing etonogestrel and "controls", using no hormonal contraceptive methods...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27889093/removal-of-a-contraceptive-implant-from-the-brachial-neurovascular-sheath
#8
Christopher Belyea, Justin Ernat, Rey Gumboc
Subdermal implantable devices are commonly used for long-acting contraception in the United States and Europe. Although relatively safe in nature, their implantation and removal may be associated with potential complications, some of which may require surgical intervention. Complications may include infection, incorrect implantation, migration, or difficulty with removal. Proximal migration has been reported; however, there are no reports of devices that have migrated within the brachial neurovascular sheath...
November 23, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27888047/looking-for-a-lost-subdermal-contraceptive-implant-think-about-the-pulmonary-artery
#9
A Gallon, M Fontarensky, C Chauffour, L Boyer, P Chabrot
This case highlights a rare but potentially life-threatening complication of a contraceptive implant insertion that was corrected by a noninvasive endovascular procedure. This procedure requires a quick intervention to be successful.
November 22, 2016: Contraception
https://www.readbyqxmd.com/read/27865875/axillary-migration-of-nexplanon%C3%A2-case-report
#10
Daniela Diego, Erryn Tappy, Jose Carugno
A 19-year-old patient presented to the clinic, and we inserted a single rod subdermal etonogestrel implant (Nexplanon ®), which subsequently migrated to the ipsilateral axilla. Distant Nexplanon® migration is a rare serious complication that should be considered when a device is nonpalpable. Management options are discussed.
November 16, 2016: Contraception
https://www.readbyqxmd.com/read/27836601/generation-of-electrical-power-under-human-skin-by-subdermal-solar-cell-arrays-for-implantable-bioelectronic-devices
#11
Kwangsun Song, Jung Hyun Han, Hyung Chae Yang, Kwang Il Nam, Jongho Lee
Medical electronic implants can significantly improve people's health and quality of life. These implants are typically powered by batteries, which usually have a finite lifetime and therefore must be replaced periodically using surgical procedures. Recently, subdermal solar cells that can generate electricity by absorbing light transmitted through skin have been proposed as a sustainable electricity source to power medical electronic implants in bodies. However, the results to date have been obtained with animal models...
November 3, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27833514/haematological-and-biochemical-effects-of-etonogestrel-subdermal-implant-implanon-in-ilorin-nigeria
#12
Olayinka R Balogun, Abiodun S Adeniran, Adebayo A Adewole
OBJECTIVES: To evaluate the effect of etonogestrel subdermal implant (Implanon) on haematological and biochemical parameters of its users. METHODOLOGY: A prospective observational study among healthy women using Implanon for contraception. The study site was the family planning clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Informed consent was obtained and participants were followed up for three years. Follow up parameters were haematological and biochemical evaluation at insertion (baseline), first and third years post-insertion...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27773713/reassessing-the-importance-of-long-acting-contraception
#13
Quentin C Karpilow, Adam T Thomas
BACKGROUND: Several recent studies have highlighted the need for greater use of long-acting contraception. The most influential of these studies is the Contraceptive CHOICE Project, which was credited with substantially reducing participants' pregnancy risk by increasing their use of long-acting methods such as intrauterine devices and subdermal implants. However, because participants' rates of nonuse and condom use fell to zero at the outset of the intervention, it is possible that sizeable pregnancy reductions could still have been achieved if enrollees had chosen shorter-acting female-controlled methods such as oral contraception...
October 20, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27725164/tamoxifen-for-the-treatment-of-breakthrough-bleeding-with-the-etonogestrel-implant-a-randomized-controlled-trial
#14
Katharine B Simmons, Alison B Edelman, Rongwei Fu, Jeffrey T Jensen
OBJECTIVE: The etonogestrel (ENG) subdermal implant can cause frequent breakthrough bleeding in some users. The objective of this study was to evaluate whether a short course of tamoxifen reduces bleeding/spotting days compared to placebo in ENG implant users. STUDY DESIGN: In this double-blind trial, we randomized ENG implant users with frequent or prolonged bleeding or spotting to tamoxifen 10 mg or placebo twice daily for 7 days, to be started after 3 consecutive days of bleeding/spotting...
October 8, 2016: Contraception
https://www.readbyqxmd.com/read/27695725/patients-perspectives-about-why-they-have-their-contraceptive-implanon-nxt-device-removed-early
#15
Meike Flore, Xiaoshuang Lilly Chen, Andrew Bonney, Judy Mullan, Bridget Dijkmans-Hadley, Adam Hodgkins, Gina Evans, Haley Frew, Gail Lloyd
BACKGROUND: Women with long-acting, reversible contraceptive devices inserted may choose to remove them prior to their planned expiry dates. OBJECTIVE: The objective of this study was to explore Australian women's experiences with the etonogestrel subdermal contraceptive implant (Implanon NXT) and why they had it removed early. METHODS: Semi-structured interviews were conducted with 18 women between June 2013 and January 2014. Transcriptions of the audio-taped interviews were analysed using a constant comparative analysis framework...
October 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27695724/australian-women-s-experiences-of-the-subdermal-contraceptive-implant-a-qualitative-perspective
#16
Kumiyo Inoue, Marguerite Kelly, Alexandra Barrett, Deborah Bateson, Kirsten I Black, Mary Stewart, Juliet Richters
BACKGROUND: The number of prescriptions for contraceptive implants has steadily increased in Australia, but implant use is still low. OBJECTIVE: The objectives of the study were to describe women's nuanced responses, and characterise their multidimensional and complex reasons for (dis)continuing use of the contraceptive implant. METHODS: A descriptive qualitative approach was used for this study. A larger qualitative study using in-depth, open-ended interviews, conducted in New South Wales between 2012 and 2013 with 94 women aged 16-49 years who had used contraception, included 10 interviews containing accounts of implant use...
October 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27692079/body-art-and-the-perioperative-process
#17
Debra Dunn
Body modification, also known as body art, has been a common cultural practice for thousands of years and includes body piercings, transdermal and subdermal implants, tattoos, scarification, body stretching and sculpting, dental grills, and nail art. Perioperative nurses must learn more about body art to provide nonjudgmental, nonprejudicial care and to ensure patient safety when they prepare patients for surgery. A welcoming environment engages patients and fosters communication so that patients are more likely to share hidden body art...
October 2016: AORN Journal
https://www.readbyqxmd.com/read/27671673/extended-use-up-to-5-years-of-the-etonogestrel-releasing-subdermal-contraceptive-implant-comparison-to-levonorgestrel-releasing-subdermal-implant
#18
Moazzam Ali, Ayse Akin, Luis Bahamondes, Vivian Brache, Ndema Habib, Sihem Landoulsi, David Hubacher
STUDY QUESTION: Is it possible to extend the use of the 3-year one-rod etonogestrel (ENG)-releasing subdermal contraceptive implant to 5 years? SUMMARY ANSWER: The extended use of the one-rod ENG-releasing subdermal contraceptive implant showed 100% efficacy in years 4 and 5. WHAT IS KNOWN ALREADY: The initial regulated trials on the ENG-releasing subdermal contraceptive implant conducted in the 1990 s were designed to measure cumulative 3-year efficacy...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27664217/immediate-versus-delayed-insertion-of-an-etonogestrel-releasing-implant-at-medical-abortion-a-randomized-controlled-equivalence-trial
#19
Helena Hognert, Helena Kopp Kallner, Sharon Cameron, Christina Nyrelli, Izabella Jawad, Rebecca Heller, Annette Aronsson, Ingela Lindh, Lina Benson, Kristina Gemzell-Danielsson
STUDY QUESTION: Does a progestin releasing subdermal contraceptive implant affect the efficacy of medical abortion if inserted at the same visit as the progesterone receptor modulator, mifepristone, at medical abortion? SUMMARY ANSWER: A etonogestrel releasing subdermal implant inserted on the day of mifepristone did not impair the efficacy of the medical abortion compared with routine insertion at 2-4 weeks after the abortion. WHAT IS ALREADY KNOWN: The etonogestrel releasing subdermal implant is one of the most effective long acting reversible contraceptive methods...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27615386/pharmacologic-treatment-of-the-ovarian-endometrioma
#20
Giuseppe Benagiano, Sun-Wei Guo, Paola Bianchi, Patrick Puttemans, Stephan Gordts, Felice Petraglia, Ivo Brosens
INTRODUCTION: Treatment of ovarian endometriomas is commonly achieved through laparoscopic surgery and this can be effective in eliminating the disease, although a majority of recent trials documented an adverse effect of surgery on ovarian reserve markers. With the advancement in imaging techniques, ovarian endometriomas are increasingly diagnosed at an earlier stage when the endometrioma may be smaller, less fibrotic and more responsive to medical treatment, making an evaluation of medical options critically important...
October 2016: Expert Opinion on Pharmacotherapy
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