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Subdermal implant

Quentin C Karpilow, Adam T Thomas
BACKGROUND: Several recent studies have highlighted the need for greater use of long-acting contraception. The most influential of these studies is the Contraceptive CHOICE Project, which was credited with substantially reducing participants' pregnancy risk by increasing their use of long-acting methods such as intrauterine devices and subdermal implants. However, because participants' rates of nonuse and condom use fell to zero at the outset of the intervention, it is possible that sizeable pregnancy reductions could still have been achieved if enrollees had chosen shorter-acting female-controlled methods such as oral contraception...
October 20, 2016: American Journal of Obstetrics and Gynecology
Katharine B Simmons, Alison B Edelman, Rongwei Fu, Jeffrey T Jensen
OBJECTIVE: The etonogestrel (ENG) subdermal implant can cause frequent breakthrough bleeding in some users. The objective of this study was to evaluate whether a short course of tamoxifen reduces bleeding/spotting days compared to placebo in ENG implant users. STUDY DESIGN: In this double-blind trial, we randomized ENG implant users with frequent or prolonged bleeding or spotting to tamoxifen 10 mg or placebo twice daily for seven days, to be started after three consecutive days of bleeding/spotting...
October 7, 2016: Contraception
Meike Flore, Xiaoshuang Lilly Chen, Andrew Bonney, Judy Mullan, Bridget Dijkmans-Hadley, Adam Hodgkins, Gina Evans, Haley Frew, Gail Lloyd
BACKGROUND: Women with long-acting, reversible contraceptive devices inserted may choose to remove them prior to their planned expiry dates. OBJECTIVE: The objective of this study was to explore Australian women's experiences with the etonogestrel subdermal contraceptive implant (Implanon NXT) and why they had it removed early. METHODS: Semi-structured interviews were conducted with 18 women between June 2013 and January 2014. Transcriptions of the audio-taped interviews were analysed using a constant comparative analysis framework...
October 2016: Australian Family Physician
Kumiyo Inoue, Marguerite Kelly, Alexandra Barrett, Deborah Bateson, Kirsten I Black, Mary Stewart, Juliet Richters
BACKGROUND: The number of prescriptions for contraceptive implants has steadily increased in Australia, but implant use is still low. OBJECTIVE: The objectives of the study were to describe women's nuanced responses, and characterise their multidimensional and complex reasons for (dis)continuing use of the contraceptive implant. METHODS: A descriptive qualitative approach was used for this study. A larger qualitative study using in-depth, open-ended interviews, conducted in New South Wales between 2012 and 2013 with 94 women aged 16-49 years who had used contraception, included 10 interviews containing accounts of implant use...
October 2016: Australian Family Physician
Debra Dunn
Body modification, also known as body art, has been a common cultural practice for thousands of years and includes body piercings, transdermal and subdermal implants, tattoos, scarification, body stretching and sculpting, dental grills, and nail art. Perioperative nurses must learn more about body art to provide nonjudgmental, nonprejudicial care and to ensure patient safety when they prepare patients for surgery. A welcoming environment engages patients and fosters communication so that patients are more likely to share hidden body art...
October 2016: AORN Journal
Moazzam Ali, Ayse Akin, Luis Bahamondes, Vivian Brache, Ndema Habib, Sihem Landoulsi, David Hubacher
STUDY QUESTION: Is it possible to extend the use of the 3-year one-rod etonogestrel (ENG)-releasing subdermal contraceptive implant to 5 years? SUMMARY ANSWER: The extended use of the one-rod ENG-releasing subdermal contraceptive implant showed 100% efficacy in years 4 and 5. WHAT IS KNOWN ALREADY: The initial regulated trials on the ENG-releasing subdermal contraceptive implant conducted in the 1990 s were designed to measure cumulative 3-year efficacy...
September 26, 2016: Human Reproduction
Helena Hognert, Helena Kopp Kallner, Sharon Cameron, Christina Nyrelli, Izabella Jawad, Rebecca Heller, Annette Aronsson, Ingela Lindh, Lina Benson, Kristina Gemzell-Danielsson
STUDY QUESTION: Does a progestin releasing subdermal contraceptive implant affect the efficacy of medical abortion if inserted at the same visit as the progesterone receptor modulator, mifepristone, at medical abortion? SUMMARY ANSWER: A etonogestrel releasing subdermal implant inserted on the day of mifepristone did not impair the efficacy of the medical abortion compared with routine insertion at 2-4 weeks after the abortion. WHAT IS ALREADY KNOWN: The etonogestrel releasing subdermal implant is one of the most effective long acting reversible contraceptive methods...
September 22, 2016: Human Reproduction
Giuseppe Benagiano, Sun-Wei Guo, Paola Bianchi, Patrick Puttemans, Stephan Gordts, Felice Petraglia, Ivo Brosens
INTRODUCTION: Treatment of ovarian endometriomas is commonly achieved through laparoscopic surgery and this can be effective in eliminating the disease, although a majority of recent trials documented an adverse effect of surgery on ovarian reserve markers. With the advancement in imaging techniques, ovarian endometriomas are increasingly diagnosed at an earlier stage when the endometrioma may be smaller, less fibrotic and more responsive to medical treatment, making an evaluation of medical options critically important...
October 2016: Expert Opinion on Pharmacotherapy
Christopher Deborde, Dan Teodor Simionescu, Cristopher Wright, Jun Liao, Leslie Neil Sierad, Agneta Simionescu
There is a significant clinical need for new approaches to treatment of mitral valve disease. The aim of this study was to develop a tissue-engineered mitral valve scaffold possessing appropriate composition and structure to ensure ideal characteristics of mitral valves, such as large orifice, rapid opening and closure, maintenance of mitral annulus-papillary muscle continuity, in vivo biocompatibility and extended durability. An extracellular matrix-based scaffold was generated, based on the native porcine mitral valve as starting material and a technique for porcine cell removal without causing damage to the matrix components...
October 3, 2016: Tissue Engineering. Part A
Li-Ya Wang, Le OuYang, Fei Tong, Xiu-Jun Zhang, Xiu-De Li, Cheng-Cheng Wang, Xiang Li, Liang Sun, Ye-Huan Sun
OBJECTIVE: The aim of this study was to investigate the association between specific contraceptives use and reproductive tract infections (RTIs). STUDY DESIGN: Participants consisted of 52,481 rural married women of reproductive age identified from a cross-sectional study in Anhui Province of China. The questionnaire, gynecological examination, and laboratory inspection were used to collect data. The subgroup analysis was performed to estimate the effect of the specific contraceptives on the specific RTIs...
August 19, 2016: Archives of Gynecology and Obstetrics
Daniel Schachter, Vince Bertucci, Nowell Solish
Calcium hydroxylapatite microspheres in a carrier gel (CaHA; Radiesse®: Merz North America, Inc., Raleigh, NC) is approved by the United States Food and Drug Administration for subdermal implantation for the correction of moderate-to-severe facial wrinkles and folds, such as nasolabial folds (NLFs). Lidocaine is often mixed with injectable dermal fillers to reduce injection pain. A new formulation of CaHA has been developed with the convenience of integral 0.3% lidocaine, CaHA (+).<br /> This multicenter, split-face, double-blind study randomized subjects to receive treatment with CaHA (+) in one NLF and CaHA without lidocaine in the contralateral NLF...
August 1, 2016: Journal of Drugs in Dermatology: JDD
Sam Rowlands, Diana Mansour, Martyn Walling
CASES: In addition to previously published case reports, further cases of intravascular migration of contraceptive implants have been identified from an information request to two national adverse reaction spontaneous reporting systems. We report on two new cases of insertion into the venous system with subsequent embolism to a pulmonary artery. CONCLUSION: Incorporating barium sulfate into the implant has facilitated diagnosis of these very rare adverse events with the initial diagnosis of embolism to the pulmonary arterial tree made by chest X-ray...
July 21, 2016: Contraception
James A Burns, Jaime L Botelho, Jonathan I Bell, William Faquin, Gerardo Lopez-Guerra, Jerome L Ackerman, James B Kobler
OBJECTIVES: Aortic homografts integrate well with laryngeal tissue when used in reconstructive surgery. It was hypothesized that a paste of aortic homograft, rich in slow-to-degrade elastin, would compare favorably in residence time and biocompatibility to predicate materials used for vocal fold injection-medialization. METHODS: An injectable aorta paste (AP) was made by pulverizing aortic homografts at -196°C (cryomilling). To assess residence time and biocompatibility, 0...
November 2016: Annals of Otology, Rhinology, and Laryngology
Katharine K Sznajder, Kathy S Tomaszewski, Anne E Burke, Maria Trent
STUDY OBJECTIVE: To estimate long-acting reversible contraception (LARC) discontinuation rates. Secondary aims were to determine risk factors for discontinuation, describe reasons for discontinuation, evaluate complications related to placement, and estimate pregnancy rates after discontinuation. DESIGN: We conducted a retrospective cohort study of LARC method use through review of electronic medical record data. SETTING: Our program is housed in an academic primary care pediatric and adolescent clinic in Baltimore, Maryland...
July 14, 2016: Journal of Pediatric and Adolescent Gynecology
Iain Bohler, Phillip Fletcher, Amanda Ragg, Andrew Vane
Epidermal inclusion cysts are benign cutaneous lesions caused by dermal or subdermal implantation and proliferation of epidermal squamous epithelium as a result of trauma or surgery. They are typically located on the scalp, face, trunk, neck, or back; however they can be found anywhere on the body. Lesions are asymptomatic unless complicated by rupture, malignant transformation to squamous cell carcinoma, or infection at which point they can clinically appear as more sinister pathologies. We present the case of a 45-year-old laborer with a ruptured epidermal inclusion cyst, manifesting clinically and radiographically as a malignancy...
2016: Case Reports in Orthopedics
Birzabith Mendoza-Novelo, Laura E Castellano, Ruth G Padilla-Miranda, María C Lona-Ramos, Patricia Cuéllar-Mata, Arturo Vega-González, Mario Murguía-Pérez, José L Mata-Mata, Eva E Ávila
The extracellular matrix molecules remaining in bioscaffolds derived from decellularized xenogeneic tissues appear to be important for inducing cell functions conducting tissue regeneration. Here, we studied whether decellularization methods, that is, detergent Triton X-100 (TX) alone and TX combined with reversible alkaline swelling (STX), applied to bovine pericardial tissue, could affect the bioscaffold components. The in vitro macrophage response, subdermal biodegradation, and cell infiltration were also studied...
November 2016: Journal of Biomedical Materials Research. Part A
K M Usinger, S B Gola, M Salas, A Smaldone
PURPOSE: Adolescents are at high risk for unintended pregnancies. While intrauterine devices (IUDs), a long-acting reversible contraceptive (LARC), are known to be highly effective in preventing pregnancy, little is known about IUD adherence in adolescents. This systematic review (SR) examines IUD continuation rates compared with other forms of contraception in young women 25 years and younger. METHODS: A systematic search of Ovid Medline, Cochrane Library, and Embase was conducted for years 1946 to 2015...
July 4, 2016: Journal of Pediatric and Adolescent Gynecology
Jungwoo Lee, Dirk Heckl, Biju Parekkadan
BACKGROUND: Immunodeficient mouse models that accept human cell and tissue grafts can contribute greater knowledge to human stem cell research. In this technical report, we used biomaterial implants seeded with genetically engineered stromal cells to create several unique microenvironments in a single mouse. The scope of study was focused on human CD34 hematopoietic stem/progenitor cell (HSPC) engraftment and differentiation within the engineered microenvironment. RESULTS: A mouse model system was created using subdermal implant sites that overexpressed a specific human cytokines (Vascular Endothelial Growth Factor A (hVEGFa), Stromal Derived Factor 1 Alpha (hSDF1a), or Tumor Necrosis Factor Alpha (hTNFa)) by stromal cells in a three-dimensional biomaterial matrix...
2016: Biomaterials Research
Kenta Uchibe, Jiyeon Son, Colleen Larmour, Maurizio Pacifici, Motomi Enomoto-Iwamoto, Masahiro Iwamoto
The nuclear retinoic acid receptors (RARs) play key roles in skeletal development and endochondral ossification. Previously we showed that RARγ regulates chondrogenesis and that pharmacological activation of RARγ blocked heterotopic ossification (HO), pathology in which endochondral bone forms in soft tissues. Thus, we reasoned that pharmacological inhibition of RARγ should enhance endochondral ossification, leading to a potential therapeutic strategy for bone deficiencies. We created surgical bone defects in wild type and RARγ-null mice and monitored bone healing...
June 21, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
David Lortscher, Shehla Admani, Nancy Satur, Lawrence F Eichenfield
INTRODUCTION: Although hormonal contraceptives may help acne or worsen it, there is limited evidence on the effects of many commonly prescribed agents. The present study evaluates patient-reported effect on acne from 2147 patients who were utilizing a hormonal contraceptive at the time of their initial consultation for acne.<BR /> METHODS: At the time of initial consultation for acne, each of 2147 consecutive patients using hormonal contraception provided her assessment of how her contraceptive had affected her acne...
June 1, 2016: Journal of Drugs in Dermatology: JDD
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