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https://www.readbyqxmd.com/read/28828592/drug-delivery-for-the-treatment-of-endometriosis-and-uterine-fibroids
#1
REVIEW
David R Friend
Endometriosis and uterine fibroids (also known as uterine leiomyomas) are serious medical conditions affecting large numbers of women worldwide. Many women are asymptomatic but those with symptoms require medical intervention to relieve chronic pain and dysmenorrhea and to address infertility. Drug delivery has played a role in reducing some of the symptoms associated with endometriosis and uterine fibroids. Use of drug delivery systems for both conditions can roughly be divided into two categories: (1) existing systems designed for other indications such as contraception for symptomatic relief and (2) development of novel systems aimed at addressing some of the underlying biochemical changes associated with endometriosis and uterine fibroids such as oxidative stress, angiogenesis, and matrix degradation...
August 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28521837/prevalence-and-predictors-of-implanon-utilization-among-women-of-reproductive-age-group-in-tigray-region-northern-ethiopia
#2
Desta Gebre-Egziabher, Araya Abrha Medhanyie, Mussie Alemayehu, Fisaha Haile Tesfay
BACKGROUND: The Ethiopian Federal Ministry of Health introduced provision of the contraceptive Implanon at community level by trained health extension workers in 2009. However, little is known regarding the utilization and factors associated with Implanon use among rural women since the introduction of the community based intervention. Thus, this study assessed the utilization of Implanon and associated factors among reproductive aged women in rural areas of Saesie-Tsaeda Emba and Ofla districts in Tigray, Northern Ethiopia...
May 18, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28260268/implanon-nxt-expert-tips-for-best-practice-insertion-and-removal
#3
Suzanne Pearson, Mary Stewart, Deborah Bateson
BACKGROUND: The single rod etonogestrel contraceptive implant is available in Australia as Implanon NXT. It is a highly effective, long-acting reversible contraceptive method, which is suitable for most women across the reproductive lifespan. OBJECTIVE: This article provides practical advice for clinicians who already insert and remove the contraceptive implant, as well as advice for those who have not yet acquired this procedural skill. DISCUSSION: Contraceptive implant procedures are usually performed in the general practice setting...
March 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28159123/who-uses-long-acting-reversible-contraception-profile-of-larc-users-in-the-cupid-cohort
#4
Jacqueline Coombe, Melissa L Harris, Deborah Loxton
OBJECTIVE: To explore the characteristics of long-acting reversible contraception (LARC) users in a nationally representative cohort of young Australian women aged 18-23. METHODS: Data from 3155 women who responded to a question about their contraceptive use in the previous six months at the baseline Contraceptive Use, Pregnancy Intention and Decisions (CUPID) survey were included. RESULTS: 726 (19.1%) women reported LARC use, with the Implanon being the most popular method (n = 478; 65...
March 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/28108504/youtube-and-the-single-rod-contraceptive-implant-a-content-analysis
#5
Jennifer Paul, Christy M Boraas, Mildred Duvet, Judy C Chang
BACKGROUND: Since the internet has become an important source of contraceptive information with YouTube.com as the second most visited site, we analysed contraceptive implant YouTube videos for content and clinical accuracy. METHODS: Using the terms 'contraceptive implant', 'Nexplanon' and 'Implanon', the top 20 results on YouTube by relevance and view count were identified. After excluding duplicates, single-rod implant videos in English were included. Videos were classified as providing a professional or patient perspective...
January 20, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/27979874/pilot-research-as-advocacy-the-case-of-sayana-press-in-kinshasa-democratic-republic-of-the-congo
#6
Arsene Binanga, Jane T Bertrand
In the Democratic Republic of the Congo (DRC), the Ministry of Health authorizes only physicians and nurses to give injections, with one exception-medical and nursing students may also give injections if supervised by a clinical instructor. The emergence of the injectable contraceptive Sayana Press in some African countries prompted the DRC to test the acceptability and feasibility of distributing Sayana Press and other contraceptive methods at the community level through medical and nursing students. Sayana Press is similar in formulation to the injectable contraceptive Depo-Provera but contains a lower dose and is administered subcutaneously using a single-use syringe with a short needle called the Uniject system...
December 23, 2016: Global Health, Science and Practice
https://www.readbyqxmd.com/read/27965269/safety-and-efficacy-of-the-subdermal-etonogestrel-contraceptive-implant-implanon%C3%A2
#7
Rob Beerthuizen
No abstract text is available yet for this article.
December 13, 2016: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/27908964/effects-of-the-etonogestrel-contraceptive-implant-implanon%C3%A2-on-bone-metabolism-during-lactation-a-prospective-study
#8
Candan Iltemir Duvan, Yuksel Onaran, Esra Aktepe Keskin, Ebru Yüce, Burcu Yanık, Hasan Kafali, Nilgun Ozturk Turhan
AIM: To evaluate the effects of the etonogestrel contraceptive implant (Implanon(®)) on bone metabolism in lactating women using markers for bone formation and resorption. STUDY DESIGN: This single-centre, prospective cohort study was conducted in Turgut Ozal University Medical Faculty Obstetrics and Gynecology Department with healthy lactating women aged between 24 and 38 years to compare the effect on bone metabolism of 6 months' use of either the implant or a non-hormonal contraceptive method...
December 1, 2016: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/27833514/haematological-and-biochemical-effects-of-etonogestrel-subdermal-implant-implanon-in-ilorin-nigeria
#9
Olayinka R Balogun, Abiodun S Adeniran, Adebayo A Adewole
OBJECTIVES: To evaluate the effect of etonogestrel subdermal implant (Implanon) on haematological and biochemical parameters of its users. METHODOLOGY: A prospective observational study among healthy women using Implanon for contraception. The study site was the family planning clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Informed consent was obtained and participants were followed up for three years. Follow up parameters were haematological and biochemical evaluation at insertion (baseline), first and third years post-insertion...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27695725/patients-perspectives-about-why-they-have-their-contraceptive-implanon-nxt-device-removed-early
#10
Meike Flore, Xiaoshuang Lilly Chen, Andrew Bonney, Judy Mullan, Bridget Dijkmans-Hadley, Adam Hodgkins, Gina Evans, Haley Frew, Gail Lloyd
BACKGROUND: Women with long-acting, reversible contraceptive devices inserted may choose to remove them prior to their planned expiry dates. OBJECTIVE: The objective of this study was to explore Australian women's experiences with the etonogestrel subdermal contraceptive implant (Implanon NXT) and why they had it removed early. METHODS: Semi-structured interviews were conducted with 18 women between June 2013 and January 2014. Transcriptions of the audio-taped interviews were analysed using a constant comparative analysis framework...
October 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27615386/pharmacologic-treatment-of-the-ovarian-endometrioma
#11
REVIEW
Giuseppe Benagiano, Sun-Wei Guo, Paola Bianchi, Patrick Puttemans, Stephan Gordts, Felice Petraglia, Ivo Brosens
INTRODUCTION: Treatment of ovarian endometriomas is commonly achieved through laparoscopic surgery and this can be effective in eliminating the disease, although a majority of recent trials documented an adverse effect of surgery on ovarian reserve markers. With the advancement in imaging techniques, ovarian endometriomas are increasingly diagnosed at an earlier stage when the endometrioma may be smaller, less fibrotic and more responsive to medical treatment, making an evaluation of medical options critically important...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27549429/retrospective-analysis-of-the-impact-of-increasing-access-to-long-acting-reversible-contraceptives-in-a-commercially-insured-population
#12
Amy Law, Dominic Pilon, Richard Lynen, François Laliberté, Laurence Gozalo, Patrick Lefebvre, Mei Sheng Duh
BACKGROUND: Unintended pregnancies have been shown to be associated with high costs for the healthcare system, among other adverse impacts, but could still account for up to 51 % of pregnancies in the US. Improvements in contraception among women are needed. Long acting reversible contraceptives (LARCs), which have proved their safety and efficacy, have been found to significantly decrease the risk of unintended pregnancy. Yet they are still marginally employed. This study aims at investigating the evolution of LARC use over 15 years and at assessing the impact of the introduction of newer LARCs on LARC use relative to all contraceptive use...
August 22, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27172400/declining-rates-of-sterilization-procedures-in-western-australian-women-from-1990-to-2008-the-relationship-with-age-hospital-type-and-government-policy-changes
#13
Khadra A Jama-Alol, Alexandra P Bremner, Louise M Stewart, Anna Kemp-Casey, Eva Malacova, Rachael Moorin, Adeleh Shirangi, David B Preen
OBJECTIVE: To describe trends in age-specific incidence rates of female sterilization (FS) procedures in Western Australia and to evaluate the effects of the introduction of government-subsidized contraceptive methods and the implementation of the Australian government's baby bonus policy on FS rates. DESIGN: Population-based retrospective descriptive study. SETTING: Not applicable. PATIENT(S): All women ages 15-49 undergoing an FS procedure during the period January 1, 1990, to December 31, 2008 (n = 47,360 procedures)...
September 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27125380/-safety-profile-of-etonogestrel-contraceptive-implant-nexplanon-%C3%A2-and-implanon-%C3%A2-reported-in-france
#14
C Simon, M S Agier, J Béné, C Muller, L Vrignaud, H Marret, A P Jonville-Bera
OBJECTIVES: The aim of the study was to assess the incidence of adverse effects (AE) reported with etonogestrel contraceptive implant in France (Implanon(®) and Nexplanon(®)). MATERIALS AND METHODS: All cases of AE or unintended pregnancies reported to health authorities or to the firm were analyzed. RESULTS: During 10 years, 5433 AE and 789 unintended pregnancies were reported. Only 388 (7 %) were serious. There were 1137 reports of difficulties to remove, failure to locate or migration, 430 of insertion difficulties and 203 of deformation or expulsion of the implant...
November 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/26898737/the-production-of-solid-dosage-forms-from-non-degradable-polymers
#15
Ian Major, Evert Fuenmayor, Christopher McConville
Non-degradable polymers have an important function in medicine. Solid dosage forms for longer term implantation require to be constructed from materials that will not degrade or erode over time and also offer the utmost biocompatibility and biostability. This review details the three most important non-degradable polymers for the production of solid dosage forms - silicone elastomer, ethylene vinyl acetate and thermoplastic polyurethane. The hydrophobic, thermoset silicone elastomer is utilised in the production of a broad range of devices, from urinary catheter tubing for the prevention of biofilm to intravaginal rings used to prevent HIV transmission...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26545933/a-prospective-cohort-study-of-early-postpartum-etonogestrel-implant-implanon%C3%A2-use-and-its-effect-on-duration-of-lochia
#16
Kim C Dobromilsky, Penny L Allen, Stephen H Raymond, Bhavna Maindiratta
BACKGROUND: Etonogestrel (ENG) implants (Implanon(®)/Nexplanon(®)/Implanon NXT(®)) are employed as contraception in early postpartum patients. Follow-up is often not conducted by the hospital prescriber. Little is known about duration of lochia, in a modern setting, and even less is known about the effect of ENG implants on lochia. AIMS: To determine if early postpartum (pre-discharge) insertion of Implanon for contraception was associated with a significant difference in duration of lochia...
July 2016: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/26466916/investigating-potential-effects-of-the-contraceptive-implanon-on-the-behavior-of-free-ranging-adult-female-barbary-macaques
#17
Amanda M Maijer, Stuart Semple
In recent years, the use of hormonal contraception in captive, free-ranging, and wild mammal populations has increased, but the effects on these nonhuman animals' behavior and the associated welfare impacts remain poorly understood. This study of free-ranging adult female Barbary macaques (Macaca sylvanus) at Trentham Monkey Forest compared females implanted with the progestin-only contraceptive Implanon to those not receiving contraception. Females with contraceptive implants had higher rates of self-scratching and spent more time self-grooming (2 behavioral indexes of anxiety) than those without implants...
2016: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/26396559/hormonal-treatment-for-endometriosis-associated-pelvic-pain
#18
REVIEW
Wu Shun Felix Wong, Chi Eung Danforn Lim
BACKGROUND: Endometriosis is a common gynecological problem associated with chronic pelvic pain. OBJECTIVE: To evaluate the effectiveness of current hormonal treatments of endometriosis associated pain. MATERIALS AND METHODS: Randomized Controlled studies identified from databases of Medline and Cochrane Systemic Review groups were pooled. 7 RCTs were recruited for evaluation in this review. Data from these studies were pooled and meta-analysis was performed in three comparison groups: 1) Progestogen versus GnRHa; 2) Implanon versus Progestogen (injection); 3) Combined oral contraceptive pills versus placebo and progestogen...
2011: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/26341405/rural-women-are-more-likely-to-use-long-acting-contraceptive-in-tigray-region-northern-ethiopia-a-comparative-community-based-cross-sectional-study
#19
COMPARATIVE STUDY
Mussie Alemayehu, Aster Kalayu, Alem Desta, Hailay Gebremichael, Tesfalem Hagos, Henock Yebyo
BACKGROUND: In the latest report of Ethiopian Demographic and Health Survey (EDHS) 2011, the maternal mortality ratio (MMR) was estimated at 676/100,000 live births, with total fertility rate at 4.8 and contraceptive prevalence rate at 29 %. Knowledge and utilization of long acting contraceptive in the Tigray region are low. This study aims at comparing and identifying factors related to the utilization of long acting contraceptive in urban versus rural settings of Ethiopia. METHODS: A comparative community-based cross-sectional study, comprised of quantitative and qualitative methods, was conducted among 1035 married women in Wukro (urban area) and Kilteawlaelo district (rural area) in March, 2013...
2015: BMC Women's Health
https://www.readbyqxmd.com/read/25473316/association-between-long-acting-reversible-contraceptive-use-teenage-pregnancy-and-abortion-rates-in-england
#20
Anne Connolly, Guilhem Pietri, Jingbo Yu, Samantha Humphreys
BACKGROUND: Since the late 1990s, the British government has launched major strategies to address high teenage pregnancy and abortion rates in England. These have focused in part on improving access to contraception through national campaigns. This study assessed teenage pregnancy and abortion rate trends since 1998 and possible associations with usage of long-acting reversible contraceptives (LARCs). METHODS: Teenage conception rates and age-specific abortion rates were obtained from the Office for National Statistics and the Department of Health...
2014: International Journal of Women's Health
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