Alison Edelman, Emily Boniface, Kaitlin Schrote, Marci Messerle-Forbes, Andrea O'Donnell, Jeffrey T Jensen, Leo Han
BACKGROUND: Some users of the etonogestrel contraceptive implant experience bothersome bleeding, which can reduce contraceptive satisfaction and continuation. Few strategies exist to manage this bleeding. The exact mechanism of progestin-induced bleeding is unknown, but it is likely multifactorial (eg, impaired angiogenesis, "leaky" fragile vasculature, and inflammation). Curcumin, the active ingredient in turmeric, has anti-inflammatory, antiproliferative, and antiangiogenic properties, which may make it a useful agent for implant-associated bothersome bleeding...
August 2023: American Journal of Obstetrics and Gynecology