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Diabetes. Insulin pump

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https://www.readbyqxmd.com/read/29923262/continuous-glucose-monitoring-cgm-and-glycemic-control-among-youth-with-type-1-diabetes-t1d-international-comparison-from-the-t1d-exchange-and-dpv-initiative
#1
Daniel J DeSalvo, Kellee M Miller, Julia M Hermann, David M Maahs, Sabine E Hofer, Mark A Clements, Eggert Lilienthal, Jennifer L Sherr, Martin Tauschmann, Reinhard W Holl
BACKGROUND: To assess change in rates of pediatric real time or intermittent scanning CGM use over the past 5 years, and how it impacts glycemic control, data from 2 registries were compared: the US-based T1DX and the German/Austrian DPV. METHODS: Registry participants aged <18 years with T1D duration ≥ 1 year encompassed 29,007 individuals in 2011 and 29,150 participants in 2016. Demographic data, CGM use and HbA1c were obtained from medical records. RESULTS: CGM use increased from 2011 to 2016 in both registries across all age groups, regardless of gender, ethnic minority status or insulin delivery method...
June 20, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29922349/a-retrospective-review-of-the-clinical-characteristics-and-blood-glucose-data-from-cellnovo-system-users-using-data-collected-from-the-cellnovo-online-platform
#2
REVIEW
Olivia Hautier-Suply, Yasmin Friedmann, Julian Shapley
Technological advances have led to innovative insulin delivery systems for patients with type 1 diabetes mellitus. In particular, the combination of miniature engineering and software algorithms contained in continuous subcutaneous insulin infusion (CSII) system pumps provide the user and the healthcare practitioner with an opportunity to review and adjust blood glucose (BG) levels according to system feedback, and to modify or programme their regimen according to their needs. While CSII pumps record a number of data parameters such as BG level, carbohydrate intake, activity and insulin delivered, these data are generally 'locked in' and can only be accessed by uploading to a cloud-based system, thus information is not contemporaneous...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29916740/preserving-skin-integrity-with-chronic-device-use-in-diabetes
#3
Laurel H Messer, Cari Berget, Christie Beatson, Sarit Polsky, Gregory P Forlenza
Skin integrity and diabetes device placement are ongoing concerns for people with diabetes who utilize continuous glucose monitors (CGMs) and continuous subcutaneous insulin infusion pumps. This is especially significant for individuals with skin sensitivities, pediatric patients, and those who use devices chronically. Dermatological complications are often cited as a barrier to device use and a reason for device discontinuation. Furthermore, it is a frequent topic of discussion in diabetes follow-up visits, although little evidence-based literature exists to guide providers in managing skin integrity issues...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29914817/efficacy-and-safety-of-sensor-augmented-pump-therapy-sapt-with-predictive-low-glucose-management-in-patients-diagnosed-with-type-1-diabetes-mellitus-previously-treated-with-sapt-and-low-glucose-suspend
#4
Ana María Gómez, Diana Cristina Henao, Angelica Imitola, Oscar Mauricio Muñoz, Martín Alonso Rondón Sepúlveda, Laura Kattah, Juan Sebastian Guerrero, Elly Morros, Juan Pablo Llano, Maira García Jaramillo, Fabián León-Vargas
BACKGROUND: Sensor-augmented insulin pump therapy (SAPT) with low-glucose suspend (LGS) is an effective and safe alternative for treating patients with type 1 diabetes mellitus (T1DM). New predictive low-glucose management (PLGM) systems decrease the severity and duration of hypoglycemic events. However, evidence of benefits in patients previously treated with SAPT-LGS is limited. METHODS: A prospective before-after study was conducted in patients with T1DM treated with SAPT-LGS, who were switched to the Minimed® 640G system with SmartGuard® to assess the impact on A1c levels, severe hypoglycemia (SH), hypoglycemia unawareness (HU), and area under the curve (AUC) <70mg/dL after three months of follow-up...
June 15, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29898180/dental-caries-and-bacterial-load-in-saliva-and-dental-biofilm-of-type-1-diabetics-on-continuous-subcutaneous-insulin-infusion
#5
Ana Coelho, Anabela Paula, Marta Mota, Mafalda Laranjo, Margarida Abrantes, Francisco Carrilho, Manuel Ferreira, Mário Silva, Filomena Botelho, Eunice Carrilho
OBJECTIVES: Since most of the studies evaluates diabetics on multiple daily injections therapy and continuous subcutaneous insulin infusion may help gain better metabolic control and prevent complications, the objective of this study was to evaluate the prevalence of dental caries, the unstimulated salivary flow rate and the total bacteria load, Streptococcus spp. levels and Lactobacillus spp. levels in saliva and supragingival dental biofilm of type 1 diabetics on insulin pump. MATERIAL AND METHODS: Sixty patients with type 1 diabetes on insulin pump and 60 nondiabetic individuals were included...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29896782/permanent-neonatal-diabetes-combining-sulfonylureas-with-insulin-may-be-an-effective-treatment
#6
S Misra, N Vedovato, E Cliff, E De Franco, A T Hattersley, F M Ashcroft, N S Oliver
BACKGROUND: Permanent neonatal diabetes caused by mutations in the KCNJ11 gene may be managed with high-dose sulfonylureas. Complete transfer to sulfonylureas is not successful in all cases and can result in insulin monotherapy. In such cases, the outcomes of combining sulfonylureas with insulin have not been fully explored. We present the case of a woman with diabetes due to a KCNJ11 mutation, in whom combination therapy led to clinically meaningful improvements. CASE: A 22-year-old woman was found to have a KCNJ11 mutation (G334V) following diagnosis with diabetes at 3 weeks...
June 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29893593/skin-problems-associated-with-insulin-pumps-and-sensors-in-adults-with-type-1-diabetes-a-cross-sectional-study
#7
Anna Korsgaard Berg, Kirsten Nørgaard, Jacob P Thyssen, Claus Zachariae, Eva Hommel, Karen Rytter, Jannet Svensson
BACKGROUND: In the future, widespread use of closed-loop infusion (artificial pancreas) systems to treat type 1 diabetes (T1D) may significantly improve glycemic control and enhance treatment flexibility. However, the infusion sets and plasters necessary for these treatments can cause dermatological complications that may hamper the spread of the new technology; few studies have investigated these complications in adults. The aim of this study was to describe the dermatological complications associated with continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) in adults...
June 12, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29893044/insulin-pump-breakdown-and-infusion-set-failure-in-italian-children-with-type-1-diabetes-1-year-prospective-observational-study-with-suggestions-to-minimize-clinical-impact
#8
Ivana Rabbone, Nicola Minuto, Sonia Toni, Fortunato Lombardo, Dario Iafusco, Marco Marigliano, Riccardo Schiaffini, G Maltoni, Anna Paola Frongia, Marco Scardapane, Antonio Nicolucci, Valentino Cherubini, Riccardo Bonfanti, Andrea E Scaramuzza
AIMS: Incidence of insulin pump failures in a cohort of children and adolescents with type 1 diabetes was evaluated prospectively during a 1-yr follow-up. MATERIALS AND METHODS: Insulin pump breakdown and infusion set failures were prospectively registered in a cohort of 1046 children and adolescents from 25 tertiary pediatric diabetes centers (50% males, mean age 12.2±4.1 yrs), with type 1 diabetes since 6.7±3.6 yrs, and using insulin pump since 3.3±2.2 yrs...
June 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29886443/effect-of-6-months-of-hybrid-closed-loop-insulin-delivery-in-adults-with-type-1-diabetes-a-randomised-controlled-trial-protocol
#9
Sybil A McAuley, Martin I de Bock, Vijaya Sundararajan, Melissa H Lee, Barbora Paldus, Geoff R Ambler, Leon A Bach, Morton G Burt, Fergus J Cameron, Philip M Clarke, Neale D Cohen, Peter G Colman, Elizabeth A Davis, Jan M Fairchild, Christel Hendrieckx, D Jane Holmes-Walker, Jodie C Horsburgh, Alicia J Jenkins, Joey Kaye, Anthony C Keech, Bruce R King, Kavita Kumareswaran, Richard J MacIsaac, Roland W McCallum, Jennifer A Nicholas, Catriona Sims, Jane Speight, Stephen N Stranks, Steven Trawley, Glenn M Ward, Sara Vogrin, Timothy W Jones, David N O'Neal
INTRODUCTION: Manual determination of insulin dosing largely fails to optimise glucose control in type 1 diabetes. Automated insulin delivery via closed-loop systems has improved glucose control in short-term studies. The objective of the present study is to determine the effectiveness of 6 months' closed-loop compared with manually determined insulin dosing on time-in-target glucose range in adults with type 1 diabetes. METHODS AND ANALYSIS: This open-label, seven-centre, randomised controlled parallel group clinical trial will compare home-based hybrid closed-loop versus standard diabetes therapy in Australia...
June 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29885025/adjusting-insulin-doses-in-patients-with-type-1-diabetes-that-use-insulin-pump-and-continuous-glucose-monitoring-variations-among-countries-and-physicians
#10
Revital Nimri, Eyal Dassau, Tomer Segall, Ido Muller, Natasa Bratina, Olga Kordonouri, Rachel Bello, Torben Biester, Klemen Dovc, Ariel Tenenbaum, Avivit Brener, Marko Šimunović, Sophia D Sakka, Michal Nevo Shenker, Caroline Gb Passone, Irene Rutigliano, Davide Tinti, Clara Bonura, Silvana Caiulo, Anna Ruszala, Barbara Piccini, Dinesh Giri, Ronnie Stein, Ivana Rabbone, Patrizia Bruzzi, Jasna Šuput Omladič, Caroline Steele, Guglielmo Beccuti, Michal Yackobovitch-Gavan, Tadej Battelino, Thomas Danne, Eran Atlas, Moshe Phillip
AIMS: To evaluate physicians' adjustments of insulin pump settings based on continuous glucose monitoring (CGM) for patients with type 1 diabetes and to compare physicians' to automated insulin dose adjustments. METHODS: 26 physicians from 16 centers in Europe, Israel and South-America participated in the study. All were asked to adjust insulin dosing based on insulin pump, CGM and glucometer downloads of 15 patients (mean age 16.2 ± 4.3 y, 6 females, mean A1c 8...
June 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29883192/lessons-learned-from-implementing-a-new-testing-educational-tool-for-patients-using-an-insulin-pump
#11
Katerina Stechova, Miroslav Vanis, Martina Tuhackova, Krzysztof Urbaniec, Milan Kvapil
BACKGROUND: To improve insulin pump therapy results, a special test for patients was devised. The model successfully used to achieve a license to operate different machines was followed. METHODS: The test (a practice and a full run, with a time limit) contained 42 questions, each with four optional choices, and could be answered online. Patients could familiarize themselves with the whole question pool first. Patients could repeat a full run attempt if they failed and were offered focused remedial education...
June 8, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29873517/the-hybrid-closed-loop-system-evolution-and-practical-applications
#12
Kathryn W Weaver, Irl B Hirsch
Achievement of well-controlled blood glucose is essential for preventing complications in patients with type 1 diabetes. Since the inception of continuous subcutaneous insulin infusion, the aim has been to develop an artificial pancreas, with the ability to use an automated algorithm to deliver one or more hormones in response to blood glucose with the intent to keep blood sugar as close to a prespecified target as possible. Development and rapid improvement of continuous glucose sensor technology has recently allowed swift progress toward a fully closed-loop insulin delivery system...
June 6, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29870275/the-clinical-impact-of-glp-1-receptor-agonists-in-type-2-diabetes-focus-on-the-long-acting-analogs
#13
Helena W Rodbard
GLP-1 receptor agonists (GLP-1 RAs), introduced for clinical use in 2005, have excellent potency in reducing HbA1c and mean glucose, improving fasting plasma glucose, inducing weight loss or protecting against the weight gain associated with insulin therapy, reducing appetite, and delaying gastric emptying. Two of these medications, liraglutide and semaglutide, appear to have cardioprotective effects as reflected in cardiovascular outcomes studies. The GLP-1 RAs are associated with gastrointestinal side effects that tend to diminish over time...
June 5, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29862649/contribution-of-basal-and-postprandial-hyperglycemia-in-type-2-diabetes-patients-treated-by-an-intensified-insulin-regimen-impact-of-pump-therapy-in-the-opt2mise-trial
#14
Yves Reznik, Aklilu Habteab, Javier Castaneda, John Shin, Michael Joubert
AIMS: The relative contribution of basal hyperglycemia (BHG) and postprandial hyperglycemia (PPHG) in type 2 diabetes patients treated with multiple daily injections (MDI) of insulin is poorly documented. In this study, the BHG and PPHG of OpT2mise patients initially treated with MDI were assessed before randomization and after 6 months of continuous subcutaneous insulin infusion (CSII). MATERIALS AND METHODS: Blinded Continuous Glucose Monitoring (CGM) data were collected in 259 MDI patients after completion of an 8-week run-in period...
June 4, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29848066/c-peptide-and-beta-cell-autoantibody-testing-prior-to-initiating-continuous-subcutaneous-insulin-infusion-csii-pump-therapy-did-not-improve-utilization-or-medical-costs-among-older-adults-with-diabetes-mellitus-dm
#15
Max Gill, Harmeet Chhabra, Mona Shah, Cyrus Zhu, George Grunberger
OBJECTIVE: To study the impact of the C-peptide and β-cell autoantibody testing required by the Center for Medicare and Medicaid Services (CMS) on costs/utilization for patients with diabetes mellitus (DM) initiating continuous subcutaneous insulin infusion (CSII) therapy. METHODS: This retrospective study used propensity score-matched patients. Analysis 1 compared patients 1-year pre- and 2-year post-CSII adoption who met or did not meet CMS criteria. Analysis 2 compared Medicare Advantage patients using CSII or multiple daily injections (MDI), who did not meet CMS criteria, for 1-year pre- and 1-year post-CSII adoption...
May 31, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29847166/improved-hba1c-total-daily-insulin-dose-and-treatment-satisfaction-with-insulin-pump-therapy-compared-to-multiple-daily-insulin-injections-in-patients-with-type-2-diabetes-irrespective-of-baseline-c-peptide-levels
#16
Robert A Vigersky, Suiying Huang, Toni L Cordero, John Shin, Scott W Lee, Harmeet Chhabra, Francine R Kaufman, Ohad Cohen
OBJECTIVE: Fasting C-peptide levels are used to differentiate type 1 from type 2 diabetes (T2D), thereby determining eligibility for coverage of continuous subcutaneous insulin infusion (CSII) for patients with T2D. METHODS: A total of 168 patients (74 female/94 male, aged 55.5 ± 9.7 years) were randomized to CSII, and 163 patients (77 female/86 male, aged 56.4 ± 9.5 years) were randomized to multiple daily injections (MDI) of insulin and grouped by baseline C-peptide level: group A (≤183 pmol/L [≤0...
May 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29844719/a-qualitative-study-exploring-patients-experiences-regarding-insulin-pump-use
#17
Zahra Khalil Alsairafi, Felicity J Smith, Kevin Michael Geoffrey Taylor, Fatemah Alsaleh, Abdulnabi T Alattar
Background: Diabetes is a threat to peoples' lives around the world, particularly in the Middle East. Medicine misuse and poor glycaemic control are prevalent among patients with type 2 diabetes, especially insulin-dependent patients (Alsairafi et al., 2016). With advances in medical technology, insulin pumps became a treatment option for patients with type 1 diabetes and those with insulin-dependent type 2 diabetes. However, use of these devices is still lacking in Kuwait, particularly in patients with type 2 diabetes...
May 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29802144/type-1-diabetes-self-management-from-emerging-adulthood-through-older-adulthood
#18
Margaret M McCarthy, Margaret Grey
OBJECTIVE: The purpose of this study of adults with type 1 diabetes was to analyze patterns of diabetes self-management behaviors and predictors of glycemic control across the adult life span. RESEARCH DESIGN AND METHODS: This study was a secondary cross-sectional analysis of data from of 7,153 adults enrolled in the Type 1 Diabetes Exchange clinic registry who were divided into four developmental stages (emerging, young, middle-aged, and older adults). Data were collected by questionnaire and medical record review at enrollment...
May 25, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29796246/pharmacotherapy-of-type1-diabetes-in-children-and-adolescents-more-than-insulin
#19
REVIEW
Torben Biester, Olga Kordonouri, Thomas Danne
For paediatric patients with type 1 diabetes, intensified insulin therapy with either multiple daily injection or insulin pump therapy is currently the only method of treatment. To optimize this therapy, insulin analogues are fixed parts of all therapy regimens. New ultra-rapid insulins seem to be beneficial not only in adults but also in this age group. New developments in long-acting analogues have demonstrated safety and will be regular in paediatrics, we hope, soon. Furthermore, the psychosocial approach for consideration of real-life aspects becomes more the focus of therapeutic regimens and is implemented into international guidelines...
May 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29789227/cost-effectiveness-analysis-of-sensor-augmented-pump-therapy-with-low-glucose-suspend-in-patients-with-type-1-diabetes-mellitus-and-high-risk-of-hypoglycemia-in-spain
#20
Ignacio Conget, Pilar Martín-Vaquero, Stéphane Roze, Isabel Elías, Cristina Pineda, María Álvarez, Alexis Delbaere, Francisco Javier Ampudia-Blasco
OBJECTIVE: To compare the cost-effectiveness of sensor-augmented pump therapy (SAP) [continuous subcutaneous insulin infusion (CSII) plus real-time continuous glucose monitoring (RT-CGM)] with low glucose suspend (MiniMed™ Veo™) and CSII alone in patients with type 1 diabetes mellitus (T1DM) at high risk of hypoglycemia in Spain. METHODS: The IQVIA CORE Diabetes Model was used to estimate healthcare outcomes as life-years gained (LYGs) and quality-adjusted life years (QALYs), and to project lifetime costs...
May 19, 2018: Endocrinología, Diabetes y Nutrición
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