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Diabetes. Insulin pump

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https://www.readbyqxmd.com/read/28429854/application-of-3c-insulin-pump-system-in-combination-with-non-invasive-ventilation-in-the-treatment-of-a-patient-with-type-2-diabetes-and-obstructive-sleep-apnea-syndrome
#1
Peng Dong, Jing Xu, Junhong Wang, Chunhong Zhang
We observed the curative effect of 3C insulin system in combination with non-invasive ventilation in a patient with type 2 diabetes and obstructive sleep apnea syndrome (OSAS). 3C insulin pump is a system of devices that closely monitors and effectively regulates blood glucose levels. Non-invasive ventilation has been shown to be an effective treatment for OSAS. A type 2 diabetic patient with concomitant OSAS was treated with a 3C insulin pump system for real-time continuous glucose monitoring and nocturnal non-invasive ventilation for OSAS...
April 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28426239/performance-of-an-artificial-pancreas-system-for-young-children-with-type-1-diabetes
#2
Mark D DeBoer, Marc D Breton, Christian Wakeman, Elaine M Schertz, Emma G Emory, Jessica L Robic, Laura L Kollar, Boris P Kovatchev, Daniel R Cherñavvsky
BACKGROUND: Young children 5-8 years old with type 1 diabetes (T1D) exhibit clear needs for improved glycemic control but may be limited in their ability to safely interact with an artificial pancreas system. Our goal was to evaluate the safety and performance of an artificial pancreas (AP) system among young children with T1D. RESEARCH DESIGN AND METHODS: In a randomized, crossover trial, children with T1D age 5-8 years were enrolled to receive on separate study periods (in random order) either the UVa AP using the DiAs Control Platform software with child-resistant lock-out screens (followed as an out-patient admission) or their usual insulin pump+continuous glucose monitor (CGM) care at home...
April 20, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28425167/continuous-subcutaneous-insulin-infusion-special-needs-for-children
#3
REVIEW
Peter Adolfsson, Ralph Ziegler, Ragnar Hanas
Continuous subcutaneous insulin infusion (CSII) is a very common therapy for children with type 1 diabetes. Due to physiological differences they have other requirements for their insulin pump than adults. The main difference is the need for very low basal rates. Even though most available insulin pumps reach a high accuracy at usual basal rates, accuracy decreases for lower rates. In addition, the lowest delivered amount at 1 time is limiting the fine tuning of the basal rate as well as the option for temporary basal rates...
April 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28417874/effectiveness-of-minimed-640g-with-smartguard%C3%A2-system-for-prevention-of-hypoglycemia-in-pediatric-patients-with-type-1-diabetes-mellitus
#4
Beatriz Villafuerte Quispe, María Martín Frías, M Belén Roldán Martín, Rosa Yelmo Valverde, M Ángeles Álvarez Gómez, Raquel Barrio Castellanos
INTRODUCTION/AIMS: Treatment with the MiniMed 640G-SmartGuard(®) system (640G-SG, sensor-augmented insulin pump system with low predicted glucose suspension feature) has been shown to decrease risk of hypoglycemia without altering metabolic control in patients with T1DM. The study purpose was to assess the impact of 640G-SG on hipoglycemia frequency and on metabolic control in a pediatric population with T1DM. PATIENTS/METHODS: A retrospective study on 21 children treated with 640G-SG...
April 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28413931/glucose-variations-and-activity-are-strongly-coupled-in-sleep-and-wake-in-young-adults-with-type-1-diabetes
#5
Sarah S Farabi, David W Carley, Lauretta Quinn
BACKGROUND: Glucose variations are common throughout sleep and wakefulness in people with type 1 diabetes mellitus (T1DM). The objective of this investigation was to characterize the time-varying coupling between glucose and unstructured physical activity over a 60-hr period in young adults with T1DM. The hypothesis was that coupling would differ during sleep versus wakefulness and would exhibit circadian variations. METHOD: Young adults with T1DM treated with an insulin pump participated in the study...
May 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28406149/implantable-batteryless-device-for-on-demand-and-pulsatile-insulin-administration
#6
Seung Ho Lee, Young Bin Lee, Byung Hwi Kim, Cheol Lee, Young Min Cho, Se-Na Kim, Chun Gwon Park, Yong-Chan Cho, Young Bin Choy
Many implantable systems have been designed for long-term, pulsatile delivery of insulin, but the lifetime of these devices is limited by the need for battery replacement and consequent replacement surgery. Here we propose a batteryless, fully implantable insulin pump that can be actuated by a magnetic field. The pump is prepared by simple-assembly of magnets and constituent units and comprises a drug reservoir and actuator equipped with a plunger and barrel, each assembled with a magnet. The plunger moves to noninvasively infuse insulin only when a magnetic field is applied on the exterior surface of the body...
April 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28406039/a-methodology-to-compare-insulin-dosing-recommendations-in-real-life-settings
#7
Danielle Groat, Maria A Grando, Bithika Thompson, Pedro Neto, Hiral Soni, Mary E Boyle, Marilyn Bailey, Curtiss B Cook
BACKGROUND: We propose a methodology to analyze complex real-life glucose data in insulin pump users. METHODS: Patients with type 1 diabetes (T1D) on insulin pumps were recruited from an academic endocrinology practice. Glucose data, insulin bolus (IB) amounts, and self-reported alcohol consumption and exercise events were collected for 30 days. Rules were developed to retrospectively compare IB recommendations from the insulin pump bolus calculator (IPBC) against recommendations from a proposed decision aid (PDA) and for assessing the PDA's recommendation for exercise and alcohol...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28400862/an-audit-of-clinical-practice-in-a-single-centre-in-kuwait-management-of-children-on-continuous-subcutaneous-insulin-infusion-and-cardiovascular-risk-factors-screening
#8
Dina Omar, Hala Alsanae, Mona Al Khawari, Majedah Abdulrasoul, Zahraa Rahme, Faisal Al Refaei, Kazem Behbehani, Azza Shaltout
OBJECTIVES: To audit the current clinical practice of continuous subcutaneous insulin infusion (CSII) for the treatment of type 1 diabetes mellitus (T1D) in children and adolescents attending a single centre in Kuwait. METHODS: A one year retrospective audit was performed in children and adolescents with T1D on CSII, who attended the paediatric diabetes clinic, Dasman Diabetes Institute during 2012. The primary outcome measure was glycaemic control as evidenced by glycated haemoglobin (HbA1c) level and the secondary outcome measures were the frequency of monitoring of the risk for microvascular complications and occurrence of acute complications and adverse events...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/28373033/the-influence-of-proton-pump-inhibitors-on-glycemic-control-a-systematic-review-of-the-literature-and-a-meta-analysis
#9
Juan C Gómez-Izquierdo, Oriana Hoi Yun Yu
OBJECTIVES: Proton-pump inhibitors (PPIs) have shown antihyperglycemic effects by stimulating insulin secretion. The aim of this study was to analyze the effect of PPIs on glucose metabolism in general and any potential antidiabetes effects in patients with type 2 diabetes. METHODS: A systematic search was conducted in MEDLINE, Embase, Cochrane and PubMed. Studies using PPIs as interventions and reporting glucose levels, glycated hemoglobin (A1C) levels and insulin levels were selected...
March 31, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28371223/faster-insulin-action-is-associated-with-improved-glycemic-outcomes-during-closed-loop-insulin-delivery-and-sensor-augmented-pump-therapy-in-adults-with-type-1-diabetes
#10
Yue Ruan, Hood Thabit, Lalantha Leelarathna, Sara Hartnell, Malgorzata E Willinska, Martin Tauschmann, Sibylle Dellweg, Carsten Benesch, Julia K Mader, Manuel Holzer, Harald Kojzar, Mark L Evans, Thomas R Pieber, Sabine Arnolds, Roman Hovorka
AIMS: To evaluate relationship between insulin pharmacodynamics and glycemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy. METHODS: We retrospectively analyzed data from multicenter randomized control trial involving 32 adults with type 1 diabetes receiving day-and-night closed-loop insulin delivery and sensor-augmented pump therapy over 12 weeks. We estimated time-to-peak insulin action (tmax,IA ) and insulin sensitivity (SI ) during both interventions and correlated these with demographic factors and glycemic outcomes...
March 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28367636/closing-the-loop-in-adults-children-and-adolescents-with-suboptimally-controlled-type-1-diabetes-under-free-living-conditions-a-psychosocial-substudy
#11
Katharine D Barnard, Timothy Wysocki, Vanessa Ully, Julia K Mader, Thomas R Pieber, Hood Thabit, Martin Tauschmann, Lalantha Leelarathna, Sara Hartnell, Carlo L Acerini, Malgorzata E Wilinska, Sibylle Dellweg, Carsten Benesch, Sabine Arnolds, Manuel Holzer, Harald Kojzar, Fiona Campbell, James Yong, Jennifer Pichierri, Peter Hindmarsh, Lutz Heinemann, Mark L Evans, Roman Hovorka
OBJECTIVE: The objective was to explore psychosocial experiences of closed loop technology for adults, children, and adolescents with type 1 diabetes and their parents taking part in two multicenter, free-living, randomized crossover home studies. METHODS: Participants using insulin pump therapy were randomized to either 12 weeks of automated closed-loop glucose control, then 12 weeks of sensor augmented insulin pump therapy (open loop), or vice versa. Closed loop was used for 24 hours by adults and overnight only by children and adolescents...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28367209/allergy-to-soft-cannula-of-insulin-pump-in-diabetic-patient
#12
Yu-Min Chen, Hui Huang
Insulin pump is a relatively good choice for diabetic patients who require multiple daily injections with wide fluctuations of blood glucose. Patients using insulin pump therapy and still having uncontrolled blood glucose levels for various factors: insulin pump not working properly, insulin instability, insulin autoantibody, insulin allergy, etc. We described a 46-year-old woman with type 2 diabetes and progressive hyperglycemia after switching multiple daily insulin injections to insulin pump, due to allergy to soft cannula of insulin pump...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28366258/-the-artificial-pancreas-a-dream-on-the-point-of-becoming-reality
#13
REVIEW
Éric Renard, Jérôme Place, Najib Benbrahim, Omar Diouri, Anne Farret
Almost 45 000 patients with type 1 diabetes are concerned in France by outpatient insulin pump therapy. The first systems of insulin pump therapy guided by glycaemia have evolved driven by the work carried out by multi-disciplinary research teams. Today, the outpatient treatment of type 1 diabetes by an artificial pancreas is on the point of becoming reality.
April 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28360027/relative-effectiveness-of-insulin-pump-treatment-over-multiple-daily-injections-and-structured-education-during-flexible-intensive-insulin-treatment-for-type-1-diabetes-cluster-randomised-trial-repose
#14
(no author information available yet)
Objective To compare the effectiveness of insulin pumps with multiple daily injections for adults with type 1 diabetes, with both groups receiving equivalent training in flexible insulin treatment.Design Pragmatic, multicentre, open label, parallel group, cluster randomised controlled trial (Relative Effectiveness of Pumps Over MDI and Structured Education (REPOSE) trial).Setting Eight secondary care centres in England and Scotland.Participants Adults with type 1 diabetes who were willing to undertake intensive insulin treatment, with no preference for pumps or multiple daily injections...
March 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28359171/a-novel-pen-based-bluetooth-enabled-insulin-delivery-system-with-insulin-dose-tracking-and-advice
#15
Timothy S Bailey, Jenine Y Stone
Diabetes is growing in prevalence internationally. As more individuals require insulin as part of their treatment, technology evolves to optimize delivery, improve adherence, and reduce dosing errors. Insulin pens outperform vial and syringe in simplicity, dosing accuracy, and user preference. Bolus advisors improve dosing confidence and treatment adherence. The InPen System offers a novel approach to treatment via a wireless pen that syncs to a mobile application featuring a bolus advisor, enabling convenient insulin dose tracking and more accurate bolus advice among other features...
April 10, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28358037/type-1-diabetes-mellitus
#16
REVIEW
Anastasia Katsarou, Soffia Gudbjörnsdottir, Araz Rawshani, Dana Dabelea, Ezio Bonifacio, Barbara J Anderson, Laura M Jacobsen, Desmond A Schatz, Åke Lernmark
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later. Although the aetiology of T1DM is not completely understood, the pathogenesis of the disease is thought to involve T cell-mediated destruction of β-cells. Islet-targeting autoantibodies that target insulin, 65 kDa glutamic acid decarboxylase, insulinoma-associated protein 2 and zinc transporter 8 - all of which are proteins associated with secretory granules in β-cells - are biomarkers of T1DM-associated autoimmunity that are found months to years before symptom onset, and can be used to identify and study individuals who are at risk of developing T1DM...
March 30, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28351897/prevention-of-hypoglycemia-with-predictive-low-glucose-insulin-suspension-in-children-with-type-1-diabetes-a-randomized-controlled-trial
#17
Tadej Battelino, Revital Nimri, Klemen Dovc, Moshe Phillip, Natasa Bratina
OBJECTIVE: To investigate whether predictive low-glucose management (PLGM) of the MiniMed 640G system significantly reduces the rate of hypoglycemia compared with sensor-augmented insulin pump in children with type 1 diabetes. RESEARCH DESIGN AND METHODS: This randomized, two-arm, parallel, controlled, two-center open-label study included 100 children and adolescents with type 1 diabetes and glycated hemoglobin A1c ≤10% (≤ 86 mmol/mol) and using continuous subcutaneous insulin infusion...
March 28, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28345762/short-term-effects-of-low-carbohydrate-diet-on-glycaemic-parameters-and-cardiovascular-risk-markers-in-patients-with-type-1-diabetes-a-randomised-open-label-cross-over-trial
#18
A Ranjan, S Schmidt, C Damm-Frydenberg, J Holst, S Madsbad, K Nørgaard
The objective was to compare effects of high carbohydrate diet (HCD) versus low carbohydrate diet (LCD) on glycaemic parameters and cardiovascular risk markers in patients with type 1 diabetes. Ten patients (4 women, insulin pump-treated, median±SD age: 48 ± 10 years, HbA1c: 53 ± 6 mmol/mol (7.0 ± 0.6%)) followed one week of isocaloric HCD (≥250 g/day) and one week of isocaloric LCD (≤50 g/day) in random order. After each week, we downloaded pump and sensor data and collected fasting blood and urine samples...
March 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28340360/the-influence-of-carbohydrate-consumption-on-glycemic-control-in-pregnant-women-with-type-1-diabetes
#19
Björg Ásbjörnsdóttir, Cecelia E Akueson, Helle Ronneby, Ane Rytter, Jens R Andersen, Peter Damm, Elisabeth R Mathiesen
AIMS: To study the influence of the quantity and the quality of carbohydrate consumption on glycemic control in early pregnancy among women with type 1 diabetes. METHODS: A retrospective study of 107 women with type 1 diabetes who completed 1-3days of diet recording before first antenatal visit, as a part of routine care. The total daily carbohydrate consumption from the major sources (e.g. bread, potatoes, rice, pasta, dairy products, fruits, candy) was calculated...
December 23, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28322429/treatment-challenges-in-type-1-diabetes-after-roux-en-y-gastric-bypass
#20
Lucie Favre, François Pralong, Michel Suter, François R Jornayvaz
Bariatric surgery is an effective treatment of type 2 diabetes in obese patients. The obesity epidemic does not spare patients with type 1 diabetes mellitus (T1DM), but there is no consensus regarding the role of surgery in the management of obese T1DM patients. Published data consistently report significant weight loss after surgery in obese T1DM patients, but long-term glycaemic control remains difficult to achieve. Here we present our experience with a challenging patient and a review of the literature. Our patient successfully underwent a roux-en-Y gastric bypass (RYGB) when she was 28 years old...
March 21, 2017: Swiss Medical Weekly
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