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Diabetes. Insulin pump

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https://www.readbyqxmd.com/read/27921428/-promising-molecules-for-treatment-of-hyperglycemia-in-patients-with-type-2-diabetes
#1
Milan Kvapil
New antidiabetic drugs are being developed today that expand the range of pharmacological intervention, in particular for patients with type 2 diabetes (imeglimin, semaglutide, dulaglutide, FGF 21 analogue). At the same time innovations take place that "better" the well-proven molecules, they offer new application forms we have no experience of diabetology (osmotic pump for exenatide, faster acting insulin aspart). New properties are brought by just the change of concentration (insulin glargine in a concentration of 300 U/ml), unexpected positive results are also brought by new fixed-ratio combinations of antidiabetics (fixed-ratio combination of insulin degludec and liraglutide, fixed-ratio combination of insulin glargine and lixisenatide)...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27914157/-prevalence-of-dental-caries-in-type-1-diabetic-patients-treated-with-insulin-pump
#2
Rosana Garcia, Ana Coelho, Anabela Paula, Manuel Marques Ferreira, Francisco Caramelo, Luísa Barros, Carla Batista, Miguel Melo, Mário Jorge Silva, Eunice Carrilho
INTRODUCTION: Type 1 diabetes mellitus and oral health are strictly related on a reciprocal basis, and an increased susceptibility to a wide variety of oral diseases is recognised in these patients. The aim of the present study was to establish a relationship between the prevalence of dental caries in Type 1 diabetic patients treated with insulin pump and that of non-diabetic patients. MATERIAL AND METHODS: An observational clinical study of analytical and cross-sectional nature was conducted...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27909691/6q24-transient-neonatal-diabetes-how-to-manage-while-waiting-for-genetic-results
#3
Julie Fudvoye, Khaldoun Farhat, Virginie De Halleux, Corina Ramona Nicolescu
Diabetes, rare in the neonatal period, should be evoked in every newborn presenting with unexplained intrauterine and early postnatal growth retardation. This case report illustrates the clinical course and therapeutic approach of a newborn diagnosed with transient diabetes. The baby was born at 37 weeks of gestation with a severe intrauterine growth restriction. Except a mild macroglossia and signs of growth restriction, physical examination was normal. On the fifth day of life, hyperglycemia (180 mg/dl) was noted, and the next day, the diagnosis of diabetes was confirmed (high blood sugar, glucosuria, undetectable levels of insulin and C-peptide)...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27899489/diabetes-device-use-in-adults-with-type-1-diabetes-barriers-to-uptake-and-potential-intervention-targets
#4
Molly L Tanenbaum, Sarah J Hanes, Kellee M Miller, Diana Naranjo, Rachel Bensen, Korey K Hood
OBJECTIVE: Diabetes devices (insulin pumps, continuous glucose monitors [CGMs]) are associated with benefits for glycemic control, yet uptake of these devices continues to be low. Some barriers to device uptake may be modifiable through psychosocial intervention, but little is known about which barriers and which patients to target. RESEARCH DESIGN AND METHODS: We surveyed 1,503 adult T1D Exchange participants (mean age 35.3 [SD 14.8] years, diagnosis duration 20...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27896954/effect-of-carbohydrate-counting-using-bolus-calculators-on-glycemic-control-in-type-1-diabetes-patients-during-continuous-subcutaneous-insulin-infusion
#5
Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire C Bastie, Yuko Tagaya, Aya Osaki, Yoko Shimoda, Ryo Shibusawa, Tsugumichi Saito, Atsushi Ozawa, Masanobu Yamada
This study examined the long-term efficacy of insulin pump therapy for type 1 diabetes patients when performed using carbohydrate counting with bolus calculators for one year. Twenty-two type 1 diabetes patients who had just started continuous subcutaneous insulin infusion were examined and divided into 2 groups: one that was educated about carbohydrate counting using bolus calculators (n=14) and another that did not use bolus calculators (n=8). After one year, the hemoglobin A1c levels of the patient group that used bolus calculators decreased persistently and significantly (P=0...
November 29, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27893687/spontaneous-and-transient-predinner-hyperglycemia-in-some-patients-with-diabetes-dusk-phenomenon
#6
Wei Li, Si-Na Du, Min-Jia Shi, Zhan-Zhan Sun
Blood glucose fluctuations have higher risk than absolute blood glucose level in diabetic chronic complications. At present, "dawn phenomenon" is well known by clinicians, but "dusk phenomenon" has not been recognized. This study explored the objective existence of "dusk phenomenon" (spontaneous and transient predinner hyperglycemia) and its clinical significance.The data of 54 patients with diabetes, who received routine insulin pump therapy between December 2010 and October 2012 in our hospital, were retrospectively analyzed...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27885706/insulin-pump-failures-in-italian-children-with-type%C3%A2-1-diabetes-retrospective-1-year-cohort-study
#7
I Rabbone, N Minuto, R Bonfanti, M Marigliano, F Cerutti, V Cherubini, G d'Annunzio, A Frongia, D Iafusco, G Ignaccolo, F Lombardo, R Schiaffini, S Toni, S Tumini, S Zucchini, A Pistorio, A E Scaramuzza
AIMS: Insulin pump failure and/or malfunction requiring replacement have not been thoroughly investigated. This study evaluated pump replacement in children and adolescents with Type 1 diabetes using insulin pump therapy. METHODS: Data were collected for all participants younger than 19 years, starting insulin pump therapy before 31 December 2013. For each child, age, disease duration, date of insulin pump therapy initiation, insulin pump model, failure/malfunction/replacement yes/no and reason were considered for the year 2013...
November 25, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27880079/relationship-between-gastric-emptying-and-diurnal-glycemic-control-in-type-1-diabetes-mellitus-a-randomized-trial
#8
Gopanandan Parthasarathy, Yogish C Kudva, Phillip A Low, Michael Camilleri, Ananda Basu, Adil E Bharucha
CONTEXT: In type 1 diabetes (T1D), delayed gastric emptying (GE) may predispose to a mismatch between insulin delivery and glucose absorption. Previous studies evaluated, only partly, the relationship between delayed GE and postprandial, but not diurnal, glycemia. OBJECTIVE: To assess the relationship between GE disturbances and glycemic control in T1D and the effects of accelerating GE on glycemic control. Design , Setting and Participants: This was a randomized placebo-controlled trial in 30 patients with T1D on an insulin pump at an academic medical center...
November 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27879355/pregnancy-outcomes-in-women-with-diabetes-lessons-learned-from-clinical-research-the-2015-norbert-freinkel-award-lecture
#9
Elisabeth R Mathiesen
Among women with diabetes, the worst pregnancy outcome is seen in the subgroup of women with diabetic nephropathy. Development of severe preeclampsia that leads to early preterm delivery is frequent. Predictors and pathophysiological mechanisms for the development of preeclampsia among women with diabetes and observational studies that support antihypertension treatment for pregnant women with microalbuminuria or diabetic nephropathy preventing preeclampsia and early preterm delivery are presented here. Obtaining and maintaining strict glycemic control before and during pregnancy is paramount to prevent preterm delivery...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27872168/accurate-carbohydrate-counting-is-an-important-determinant-of-postprandial-glycemia-in-children-and-adolescents-with-type-1-diabetes-on-insulin-pump-therapy
#10
Asma Deeb, Ahlam Al Hajeri, Iman Alhmoudi, Nico Nagelkerke
BACKGROUND: Carbohydrate (CHO) counting is a key nutritional intervention utilized in the management of diabetes to optimize postprandial glycemia. The aim of the study was to examine the impact of accuracy of CHO counting on the postprandial glucose in children and adolescents with type 1 diabetes on insulin pump therapy. METHODS: Children/adolescents with type 1 diabetes who were on insulin pump therapy for a minimum of 6 months are enrolled in the study. Patients were instructed to record details of meals consumed, estimated CHO count per meal, and 2-hour postprandial glucose readings over 3-5 days...
November 20, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27860498/clinical-outcomes-after-1-year-of-augmented-insulin-pump-therapy-in-patients-with-diabetes-in-a-specialized-diabetes-center-in-medell%C3%A3-n-colombia
#11
Alex Ramirez-Rincon, Jaime Hincapie-García, Claudia Monsalve Arango, Natalia Aristizabal, Estefany Castillo, Gloria Hincapie, Eliana Zapata, Diana Paola Cuesta, Maria Delgado, Veronica Abad, Jose Luis Torres, Andres Palacio, José Fernando Botero
BACKGROUND: Type 1 diabetes can be difficult to control. Augmented pump therapy (CSII-rtCGM) has become an important tool for controlling blood glucose and decreasing hypoglycemia. METHODS: Describe the results 1 year after starting CSII-rtCGM in patients with diabetes in Medellín, Colombia. This is an observational, retrospective study. Patients with type 1 and type 2 diabetes started on CSII-rtCGM between January 2008 and June 2015 were included. Qualitative variables were analyzed as absolute or relative frequencies...
November 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27843339/the-danish-adult-diabetes-registry
#12
REVIEW
Marit Eika Jørgensen, Jette K Kristensen, Gitte Reventlov Husted, Charlotte Cerqueira, Peter Rossing
AIM OF THE DATABASE: The aim of the Danish Adult Diabetes Registry (DADR) is to provide data from both the primary health care sector (general practice [GP]) and the secondary sector (specialized outpatient clinics) to assess the quality of treatment given to patients with diabetes. The indicators represent process and outcome indicators selected from the literature. STUDY POPULATION: The total diabetes population in Denmark is estimated to be ~300,000 adult diabetes patients...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27835049/insulin-pump-failures-has-there-been-an-improvement-update-of-a-prospective-observational-study
#13
Agathe Guenego, Guillaume Bouzillé, Stéphanie Breitel, Annabelle Esvant, Jean-Yves Poirier, Fabrice Bonnet, Isabelle Guilhem
BACKGROUND: Insulin pump failures had been assessed in our center by a prospective observational study from 2001 to 2007. The aim of this study was to update our data since 2008 and to determine whether there exist specific risk factors for insulin pump failures. METHODS: All insulin pump defects were prospectively collected between 2008 and 2013 in a monocentric cohort of 350 new pumps. Clinical consequences were recorded. Brand and model of pumps and type of defects and patients' characteristics (gender, type of diabetes, age at diabetes diagnosis, age at first pump, pump treatment duration, number of previous pumps, and number of previous pump failures) were tested for possible association with insulin pump failure...
November 11, 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27835037/glycemia-treatment-satisfaction-cognition-and-sleep-quality-in-adults-and-adolescents-with-type-1-diabetes-when-using-a-closed-loop-system-overnight-versus-sensor-augmented-pump-with-low-glucose-suspend-function-a-randomized-crossover-study
#14
Amin Sharifi, Martin I De Bock, Dilshani Jayawardene, Margaret M Loh, Jodie C Horsburgh, Carolyn L Berthold, Nirubasini Paramalingam, Leon A Bach, Peter G Colman, Elizabeth A Davis, Benyamin Grosman, Christel Hendrieckx, Alicia J Jenkins, Kavita Kumareswaran, Natalie Kurtz, Andrew Kyoong, Richard J MacIsaac, Jane Speight, Steven Trawley, Glenn M Ward, Anirban Roy, Timothy W Jones, David N O'Neal
BACKGROUND: We compared glycemia, treatment satisfaction, sleep quality, and cognition using a nighttime Android-based hybrid closed-loop system (Android-HCLS) with sensor-augmented pump with low-glucose suspend function (SAP-LGS) in people with type 1 diabetes. MATERIALS AND METHODS: An open-label, prospective, randomized crossover study of 16 adults (mean [SD] age 42.1 [9.6] years) and 12 adolescents (15.2 [1.6] years) was conducted. All participants completed four consecutive nights at home with Android-HCLS (proportional integral derivative with insulin feedback algorithm; Medtronic) and SAP-LGS...
November 11, 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27824066/a-novel-insulin-glucose-model-after-a-mixed-meal-test-in-patients-with-type-1-diabetes-on-insulin-pump-therapy
#15
Luca Marchetti, Federico Reali, Marco Dauriz, Corinna Brangani, Linda Boselli, Giulia Ceradini, Enzo Bonora, Riccardo C Bonadonna, Corrado Priami
Current closed-loop insulin delivery methods stem from sophisticated models of the glucose-insulin (G/I) system, mostly based on complex studies employing glucose tracer technology. We tested the performance of a new minimal model (GLUKINSLOOP 2.0) of the G/I system to characterize the glucose and insulin dynamics during multiple mixed meal tests (MMT) of different sizes in patients with type 1 diabetes (T1D) on insulin pump therapy (continuous subcutaneous insulin infusion, CSII). The GLUKINSLOOP 2.0 identified the G/I system, provided a close fit of the G/I time-courses and showed acceptable reproducibility of the G/I system parameters in repeated studies of identical and double-sized MMTs...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822115/danish-registry-of-childhood-and-adolescent-diabetes
#16
REVIEW
Jannet Svensson, Charlotte Cerqueira, Per Kjærsgaard, Lene Lyngsøe, Niels Thomas Hertel, Mette Madsen, Henrik B Mortensen, Jesper Johannesen
AIM: The aims of the Danish Registry of Childhood and Adolescent Diabetes (DanDiabKids) are to monitor and improve the quality of care for children and adolescents with diabetes in Denmark and to follow the incidence and prevalence of diabetes. STUDY POPULATION: The study population consists of all children diagnosed with diabetes before the age of 15 years since 1996. Since 2015, every child followed up at a pediatric center (<18 years of age) will be included...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27807014/continuous-glucose-monitoring-cgm-adherence-in-youth-with-type-1-diabetes-associations-with-biomedical-and-psychosocial-variables
#17
Elisa Giani, Rebecca Snelgrove, Lisa K Volkening, Lori M Laffel
BACKGROUND: Continuous glucose monitoring (CGM) remains underutilized in youth with type 1 diabetes (T1D). There is a need to investigate factors associated with CGM use. METHOD: In 61 T1D youth, CGM use was ascertained by downloads reflecting the 4-week periods preceding 3- and 6-month study visits. Demographic and clinical data were obtained from chart review and interview. Youth and parents completed validated psychosocial surveys at baseline and 6 months. RESULTS: Youth (52% male, 93% Caucasian, 80% pump treated) were 12...
November 1, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27805870/prolactin-promotes-adipose-tissue-fitness-and-insulin-sensitivity-in-obese-males
#18
Xarubet Ruiz-Herrera, Ericka A de Los Ríos, Juan M Díaz, Ricardo M Lerma-Alvarado, Lucía Martínez de la Escalera, Fernando López-Barrera, María Lemini, Edith Arnold, Gonzalo Martínez de la Escalera, Carmen Clapp, Yazmín Macotela
Excessive accumulation of body fat triggers insulin resistance and features of the metabolic syndrome. Recently, evidence has accumulated that obesity, type 2 diabetes, and metabolic syndrome are associated with reduced levels of serum prolactin (PRL) in humans and rodents, raising the question of whether low PRL levels contribute to metabolic dysfunction. Here, we have addressed this question by investigating the role of PRL in insulin sensitivity and adipose tissue fitness in obese rodents and humans. In diet-induced obese rats, treatment with PRL delivered via osmotic mini-pumps, improved insulin sensitivity, prevented adipocyte hypertrophy, and reduced inflammatory cytokine expression in visceral fat...
November 2, 2016: Endocrinology
https://www.readbyqxmd.com/read/27797928/low-carbohydrate-diet-impairs-the-effect-of-glucagon-in-the-treatment-of-insulin-induced-mild-hypoglycemia-a-randomized-cross-over-study
#19
Ajenthen Ranjan, Signe Schmidt, Camilla Damm-Frydenberg, Isabelle Steineck, Trine Ryberg Clausen, Jens Juul Holst, Sten Madsbad, Kirsten Nørgaard
OBJECTIVE: This study compared the ability of glucagon to restore plasma glucose (PG) after mild hypoglycemia in patients with type 1 diabetes on isocaloric high carbohydrate diet (HCD) versus a low carbohydrate diet (LCD). RESEARCH DESIGN AND METHODS: Ten patients with insulin pump-treated type 1 diabetes randomly completed 1 week of the HCD (>250 g/day) and 1 week of the LCD (<50 g/day). After each week, mild hypoglycemia was induced by a subcutaneous insulin bolus in the fasting state...
October 21, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27789976/comparison-of-rechargeable-versus-battery-operated-insulin-pumps-temperature-fluctuations
#20
Paul Vereshchetin, Thomas W McCann, Navdeep Ojha, Ramakrishna Venugopalan, Brian L Levy
The role of continuous subcutaneous insulin infusion (insulin pumps) has become increasingly important in diabetes management, and many different types of these systems are currently available. This exploratory study focused on the reported heating issues that lithium-ion battery-powered pumps may have during charging compared with battery-operated pumps. It was found that pump temperature increased by 6.4°C during a long charging cycle of a lithiumion battery-operated pump under ambient temperatures. In an environmental-chamber kept at 35°C, the pump temperature increased by 4...
2016: Medical Devices: Evidence and Research
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