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https://www.readbyqxmd.com/read/29668027/heart-transplant-in-children-what-a-primary-care-provider-needs-to-know
#1
Swati Sehgal, Emily Shea, Lauren Kelm, Deepak Kamat
Heart transplantation is offered to children with heart failure that is not amenable to medical or surgical therapy. Indications for heart transplant include unrepairable congenital heart disease, failed palliation of congenital heart disease, and cardiomyopathies. There has been tremendous progress in this field since the first heart transplant was performed in 1967. Each year, approximately 500 pediatric heart transplants take place worldwide. Pediatric heart transplant survivors are living longer with their initial transplant...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29667338/variation-in-the-tek-gene-is-not-associated-with-asthma-but-with-allergic-conjunctivitis
#2
L E Fodor, A Gézsi, Z Gál, A Nagy, A Kiss, A Bikov, C Szalai
The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans. Recently, variations in the TEK gene have been found associated with asthma. The objective of the present study was to investigate whether variations in the TEK gene influenced the susceptibility to pediatric asthma and/or associated phenotypes like GINA status, viral- or exercise-induced asthma, allergic asthma, indoor, outdoor, inhalative allergies, IgE and eosonophil levels, allergic rhinitis and allergic conjunctivitis...
April 18, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29657076/gasping-for-a-diagnosis-pediatric-vocal-cord-dysfunction
#3
Mariel Wenzel
Vocal cord dysfunction is an obstruction of the upper airway, primarily on inspiration, due to the paradoxical adduction of the vocal cords. Vocal cord dysfunction continues to be underdiagnosed as its own entity. The lack of diagnosis can be attributed to the overlap of symptoms between asthma and exercise-induced bronchospasm. It is possible for patients diagnosed with asthma and/or exercise-induced bronchospasm to have underlying vocal cord dysfunction, which needs to be considered when prescribing asthma medications...
April 13, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29628970/acute-kidney-injury-in-pediatric-patients-with-rhabdomyolysis
#4
Young Shin Lim, Heeyeon Cho, Sang Taek Lee, Yeonhee Lee
Purpose: This study aimed to evaluate the clinical findings in pediatric rhabdomyolysis and the predictive factors for acute kidney injury (AKI) in Korean children. Methods: Medical records of 39 Korean children, who were newly diagnosed with rhabdomyolysis from January 2008 to December 2015, were retrospectively analyzed. The diagnosis was made from the medical history, elevated serum creatinine kinase level >1,000 IU/L, and plasma myoglobin level >150 ng/mL...
March 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29605364/management-of-complex-pediatric-laryngotracheal-stenosis-with-skin-graft-reconstruction
#5
Sarah N Bowe, Carissa J Wentland, G S Sandhu, Christopher J Hartnick
OBJECTIVES: For pediatric patients with laryngotracheal stenosis, the ultimate goal is creation of a safe, functional airway. Unfortunately, wound healing in a hollow structure can complicate repair attempts, leading to restenosis. Herein, we present our experience using skin-grafting techniques in two complex pediatric laryngotracheal stenosis cases, leading to successful decannulation or speech production. METHODS: A chart review was performed examining the evaluation and management of two pediatric patients with laryngotracheal stenosis despite prior reconstructive attempts...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29596007/outpatient-physical-therapy-cardiovascular-assessment-physical-therapist-perspective-and-experience
#6
Ali Mufraih Albarrati
BACKGROUND: Physical therapists are recognized healthcare providers who play an important role in cardiovascular disease prevention. Heart rate (HR) and blood pressure (BP) are important parameters in cardiovascular risk assessment; however, physical therapists do not usually integrate them into clinical practice. Therefore, this study aimed to examine the current practice and opinion of outpatient physical therapists toward HR and BP measurements in clinics. METHODS: A 12-item survey questionnaire was distributed to outpatient physical therapists...
March 29, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29595826/pediatric-multiple-sclerosis-current-perspectives-on-health-behaviors
#7
REVIEW
Elizabeth Morghen Sikes, Robert W Motl, Jayne M Ness
Purpose: Pediatric-onset multiple sclerosis (POMS) accounts for ~5% of all multiple sclerosis cases, and has a prevalence of ~10,000 children in the USA. POMS is associated with a higher relapse rate, and results in irreversible disability on average 10 years earlier than adult-onset multiple sclerosis. Other manifestations of POMS include mental and physical fatigue, cognitive impairment, and depression. We believe that the health behaviors of physical activity, diet, and sleep may have potential benefits in POMS, and present a scoping review of the existing literature...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29588200/flow-limitation-and-dysanapsis-in-children-and-adolescents-with-exertional-dyspnea
#8
Paolo T Pianosi
The consequence of dysanapsis, quantitated by dysanapsis ratio (DR), on expiratory flow limitation (EFL) during exercise in pediatric subjects was examined. EFL occurred in 80 (56%) subjects from an enriched sample of children and adolescents tested during investigation of exertional dyspnea. DR was lower in subjects with vs without EFL during exercise: (0.055 ± 0.015 vs 0.067 ± 0.017, p < .001), and lower ratio correlated with greater extent of EFL (r = -.64, p < .001). EFL was seen more often in boys: 67% vs 46% (p=...
March 24, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29581998/long-term-effect-of-critical-illness-after-severe-paediatric-burn-injury-on-cardiac-function-in-adolescent-survivors-an-observational-study
#9
Gabriel Hundeshagen, David N Herndon, Robert P Clayton, Paul Wurzer, Alexis McQuitty, Kristofer Jennings, Ludwik Branski, Vanessa N Collins, Nicole Ribeiro Marques, Celeste C Finnerty, Oscar E Suman, Michael P Kinsky
Background: Sepsis, trauma, and burn injury acutely depress systolic and diastolic cardiac function; data on long-term cardiac sequelae of pediatric critical illness are sparse. This study evaluated long-term systolic and diastolic function, myocardial fibrosis, and exercise tolerance in survivors of severe pediatric burn injury. Methods: Subjects at least 5 years after severe burn (post-burn:PB) and age-matched healthy controls (HC) underwent echocardiography to quantify systolic function (ejection fraction[EF%]), diastolic function (E/e'), and myocardial fibrosis (calibrated integrated backscatter) of the left ventricle...
December 2017: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/29579311/strength-and-cardiorespiratory-exercise-rehabilitation-for-severely-burned-patients-during-intensive-care-units-a-survey-of-practice
#10
Janos Cambiaso-Daniel, Ingrid Parry, Eric Rivas, Jennifer Kemp-Offenberg, Soman Sen, Julie A Rizzo, Michael A Serghiou, Karen Kowalske, Steven E Wolf, David N Herndon, Oscar E Suman
Minimizing the deconditioning of burn injury through early rehabilitation programs (RP) in the intensive care unit (ICU) is of importance for improving the recovery time. The aim of this study was to assess current standard of care (SOC) for early ICU exercise programs in major burn centers. We designed a survey investigating exercise RP on the ICU for burn patients with >30% total burned surface area. The survey was composed of 23 questions and submitted electronically via SurveyMonkey® to six major (pediatric and adult) burn centers in Texas and California...
March 22, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29579024/assessing-technical-performance-and-determining-the-learning-curve-in-cleft-palate-surgery-using-a-high-fidelity-cleft-palate-simulator
#11
Dale J Podolsky, David M Fisher, Karen W Wong, Peter Szasz, Thomas Looi, James M Drake, Christopher R Forrest
INTRODUCTION: Technical skills assessment can provide objective measures of surgical performance. This study assessed technical performance in cleft palate repair using a newly developed assessment tool and high fidelity cleft palate simulator through a longitudinal simulation training exercise. METHODS: Three residents performed five and one resident performed nine consecutive endoscopically recorded cleft palate repairs using a cleft palate simulator. Two fellows in pediatric plastic surgery and two expert cleft surgeons also performed recorded simulated repairs...
March 19, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29578996/role-of-pediatric-physical-therapists-in-promoting-sports-participation-in-developmental-coordination-disorder
#12
Imke L J Adams, Wenke Broekkamp, Peter H Wilson, Christine Imms, Anneloes Overvelde, Bert Steenbergen
PURPOSE: To explore the role of pediatric physical therapists (PPT) in promoting sports participation in children with developmental coordination disorder (DCD) and identify associated barriers and facilitators. METHODS: Questionnaires were provided to 243 PPTs. Qualitative, semistructured, in-depth interviews were administered with the PPTs, children with DCD, and parents. RESULTS: Approximately 67% of questionnaires were returned. Approximately 46% of PPTs were active in guiding children with DCD to sports clubs...
April 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/29575607/the-maximum-qtc-of-holter-electrocardiography-in-a-pediatric-population
#13
Yoshiharu Ogawa, Toshikatsu Tanaka, Sachiko Kido
BACKGROUND: The corrected QT interval (QTc) of electrocardiograms (ECGs) at rest and after exercise in a short daytime recording period may be insufficient for the diagnosis and management of long QT syndrome (LQTS) patients, especially for those with LQTS type 2 and 3. Therefore, examining QTc using Holter ECG is important. We designed a method of analyzing QTc in Holter ECG that can be performed in daily clinical practice by combining automatic and manual measurements. METHODS: We reviewed the charts of healthy children (n=210) and LQTS patients (n=35) aged <16 years and analyzed QTc at rest, after exercise, and the maximum QTc of Holter ECG...
March 25, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29566735/feasibility-and-reliability-of-the-spondyloarthritis-research-consortium-of-canada-sacroiliac-joint-inflammation-score-in-children
#14
Pamela F Weiss, Walter P Maksymowych, Robert G Lambert, Jacob L Jaremko, David M Biko, Joel Paschke, Timothy G Brandon, Rui Xiao, Nancy A Chauvin
BACKGROUND: Published methods for quantification of magnetic resonance imaging (MRI) evidence of inflammation in the sacroiliac joint lack validation in pediatric populations. We evaluated the reliability and construct validity of the Spondyloarthritis Research Consortium of Canada (SPARCC) sacroiliac joint inflammation score (SIS) in children with suspected or confirmed juvenile spondyloarthritis (JSpA). METHODS: The SPARCC SIS measures the presence, depth, and intensity of bone marrow inflammation on MRI through the cartilaginous part of the joint...
March 22, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29565763/metabolic-and-psychological-impact-of-a-pragmatic-exercise-intervention-program-in-adolescent-and-young-adult-survivors-of-pediatric-cancer-related-cerebral-insult
#15
Shoshana R Rath, Treya M Long, Natasha L Bear, Gordon C P Miles, Andrew M Bullock, Nicholas G Gottardo, Catherine H Cole, Louise H Naylor, Catherine S Y Choong
PURPOSE: To assess metabolic function among adolescent and young adult (AYA) survivors of childhood cancer-related brain surgery or cranial irradiation (CRT) and to determine feasibility, safety, and metabolic as well as psychological impact of a 6-month exercise program in this cohort. METHODS: Twenty AYAs aged 15-23 years were recruited. All had completed cancer treatment by age 15.5 and were more than 1 year after end of treatment. Metabolic function was assessed at baseline (T1), after a 6-month non-intervention period (T2), and after the 6-month intervention (T3)...
March 22, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29557918/aerobic-exercise-during-early-murine-doxorubicin-exposure-mitigates-cardiac-toxicity
#16
Fei Wang, Brian Iskra, Eugenie Kleinerman, Claudia Alvarez-Florez, Thomas Andrews, Angela Shaw, Joya Chandra, Keri Schadler, Gregory J Aune
We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models of doxorubicin (Doxo) exposure in non-tumor-bearing immune competent (NTB-IC) mice and tumor-bearing nude mice (TB-NM). In both models, animals at 4 weeks of age underwent Doxo treatment with or without 2 weeks of simultaneous exercise. In sedentary NTB-IC or TB-NM mice, Doxo treatment resulted in a statistically significant decrease in ejection fraction and fractional shortening compared with control animals...
April 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29557631/-primary-care-in-the-adolescent-gynecological-pathology
#17
José M Méndez Ribas
The Medicine for adolescents is a true specialty mostly exercised by doctors trained in pediatrics, family clinicians and gynecologists properly trained in their care and with the vocation for that. Based on my experience as a Founding Member and Director for more than 20 years of the Adolescence Program of the Hospital de Clínicas (University of Buenos Aires), I presented a methodology of attention with the objective of showing a comprehensive approach of the adolescents with an emphasis on general health promotion and prevention of diseases, and on reproductive health in particular...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29547166/surgical-nuances-in-the-separation-of-craniopagus-twins-our-experience-and-a-follow-up-of-15-years
#18
Muralidhar Pai K, R Chandrasekhar Naidu, A Raja, Y S Rai, Niranjan Kumar, Anand Kini, Santhosh Joseph, Vinod Hegde, H S Ballal, Ramoorthi Rao, Saroja V Sharma, Vinay Kumar Valakatte
Craniopagus twins are conjoined twins fused at the cranium. This is the rarest anomaly seen in conjoined twins and craniopagus twins account for 2- 6% of conjoined twins. Conjoined twins are also extremely rare, with the anomaly seen in about 10-20 subjects per billion births. A female preponderance has been noted. Craniopagus twins can be classified into complete or partial, depending on whether or not they have shared dural venous sinuses. They can be further classified into angular or total depending on the alignment of the inter-twin longitudinal axis...
March 2018: Neurology India
https://www.readbyqxmd.com/read/29523922/a-novel-mechanism-for-improved-exercise-performance-in-pediatric-fontan-patients-after-cardiac-rehabilitation
#19
Samuel Wittekind, Wayne Mays, Yvette Gerdes, Sandra Knecht, John Hambrook, William Border, John Lynn Jefferies
Patients with a Fontan circulation have impaired exercise capacity. Cardiac rehabilitation (CR) has shown promise in enhancing peak exercise parameters in this population, but an improvement in submaximal exercise has not been consistently demonstrated. We assessed the hypothesis that participation in CR will be associated with more efficient oxygen extraction and ventilation during submaximal exercise. In this prospective study, pediatric Fontans completed two 60 min CR sessions per week for 12 weeks. Cardiopulmonary exercise testing and stress echocardiography were performed at baseline and last CR session, and then compared with a paired sample t test...
March 9, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29521004/delayed-puberty-and-abnormal-anthropometry-and-its-associations-with-quality-of-life-in-young-fontan-survivors-a-multicenter-cross-sectional-study
#20
Shaji C Menon, Ragheed Al-Dulaimi, Brian W McCrindle, David J Goldberg, Ritu Sachdeva, Bryan H Goldstein, Thomas Seery, Karen C Uzark, Anjali Chelliah, Ryan Butts, Heather Henderson, Tiffanie Johnson, Richard V Williams
INTRODUCTION: We sought to evaluate the prevalence of delayed puberty and abnormal anthropometry and its association with quality of life (QoL) in young Fontan survivors. METHODS: This was a cross-sectional study at 11 Pediatric Heart Network centers. Demographic and clinical data, anthropomety, and Tanner stage were collected. Anthropometric measurements and pubertal stage were compared to US norms. QoL was assessed using Pediatric Quality of Life inventory (PedsQL)...
March 9, 2018: Congenital Heart Disease
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