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https://www.readbyqxmd.com/read/28920084/effects-of-methamphetamine-on-locomotor-activity-and-thalamic-gene-expression-in-leptin-deficient-obese-mice
#1
Betina González, Candela González, Verónica Bisagno, Francisco J Urbano
Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons. The leptin deficient mouse (ob/ob) has been used as an animal model of blunted leptin action, and presents with obesity and mild type 2 diabetes. We used ob/ob mice to study the effect of repeated 7-day methamphetamine (METH) administration analyzing locomotion, behavioral sensitization, and somatosensory thalamic mRNA expression of voltage-gated calcium channels and glutamatergic receptors using RT-PCR...
July 2017: Translational Brain Rhythmicity
https://www.readbyqxmd.com/read/28890714/gut-microbiota-analysis-in-rats-with-methamphetamine-induced-conditioned-place-preference
#2
Tingting Ning, Xiaokang Gong, Lingling Xie, Baomiao Ma
Methamphetamine abuse is a major public health crisis. Because accumulating evidence supports the hypothesis that the gut microbiota plays an important role in central nervous system (CNS) function, and research on the roles of the microbiome in CNS disorders holds conceivable promise for developing novel therapeutic avenues for treating CNS disorders, we sought to determine whether administration of methamphetamine leads to alterations in the intestinal microbiota. In this study, the gut microbiota profiles of rats with methamphetamine-induced conditioned place preference (CPP) were analyzed through 16S rRNA gene sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28877870/circadian-variability-of-body-temperature-responses-to-methamphetamine
#3
Abolhassan Behrouzvaziri, Maria V Zaretskaia, Daniel Edward Rusyniak, Dmitry V Zaretsky, Yaroslav I Molkov
Vital parameters of living organisms exhibit circadian rhythmicity. Although rats are nocturnal animals, most of the studies involving rats are performed during the day. The objective of this study was to examine the circadian variability of the body temperature responses to methamphetamine (Meth). Body temperature was recorded in male Sprague-Dawley rats received Meth (1 or 5 mg/kg) or saline at 10am or 10pm. The baseline body temperature at night was 0.8ºC higher than during the day. Both during the day and at night 1 mg/kg of Meth induced monophasic hyperthermia...
September 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28870635/cannabidiol-inhibits-priming-induced-reinstatement-of-methamphetamine-in-rem-sleep-deprived-rats
#4
Saeideh Karimi-Haghighi, Abbas Haghparast
Methamphetamine (METH) is a widely abused and a severely addictive psychostimulant. Relapse is the main cause of concern when treating addiction. It could manifest after a long period of abstinence. Previous studies showed that there is a strong connection between sleep impairment and relapse. Also, it has been reported that cannabidiol might be a potential treatment for drug craving and relapse. In this study, we used conditioned place preference (CPP) to investigate whether Cannabidiol (CBD), a phytocannabinoid, can prevent METH-induced reinstatement in Rapid Eye Movement Sleep Deprived (RSD) rats...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28870523/antagonism-of-mglu2-3-receptors-in-the-nucleus-accumbens-prevents-oxytocin-from-reducing-cued-methamphetamine-seeking-in-male-and-female-rats
#5
Aurelien Bernheim, Kah-Chung Leong, Carole Berini, Carmela M Reichel
Methamphetamine (meth) addiction is a prevalent health concern worldwide, yet remains without approved pharmacological treatments. Preclinical evidence suggests that oxytocin may decrease relapse, but the neuronal underpinnings driving this effect remain unknown. Here we investigate whether oxytocin's effect is dependent on presynaptic glutamatergic regulation in the nucleus accumbens core (NAcore) by blocking metabotropic glutamate receptors 2/3 (mGluR2/3). Male and female Sprague-Dawley rats self-administered meth or sucrose on an escalating fixed ratio, followed by extinction and cue-induced reinstatement sessions...
September 1, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28861718/repeated-forced-swim-exacerbates-methamphetamine-induced-neurotoxicity-neuroprotective-effects-of-nanowired-delivery-of-5-ht3-receptor-antagonist-ondansetron
#6
José Vicente Lafuente, Aruna Sharma, Dafin F Muresanu, Asya Ozkizilcik, Z Ryan Tian, Ranjana Patnaik, Hari S Sharma
The possibility that stress associated with chronic forced swim (FS) may exacerbate methamphetamine (METH) neurotoxicity was examined in a rat model. Rats were subjected to FS in a pool (30 °C) for 15 min daily for 8 days. Control rats were kept at room temperature. METH was administered (9 mg/kg, s.c.) in both control and FS rats and allowed to survive 4 h after the drug injection. METH in FS rats exacerbated BBB breakdown to Evans blue albumin (EBA) by 150 to 220% and ([131])-Iodine by 250 to 380% as compared to naive rats after METH...
August 31, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28859474/aggregated-single-walled-carbon-nanotubes-absorb-and-deform-dopamine-related-proteins-based-on-molecular-dynamics-simulations
#7
Yi Yu, Huiyong Sun, Keith Gilmore, Tingjun Hou, Suidong Wang, Youyong Li
Single-walled carbon nanotubes (SWCNTs) have attracted considerable attention owing to their applications in various fields such as biotechnology and biomedicine. Recently, aggregated SWCNTs have shown more significant effects on the treatment of methamphetamine addiction (Nat. Nanotech. 2016, 11, 613). However, the mechanisms underlying these actions are unclear. By using all-atom molecular dynamics simulations, we investigate the effects of single and aggregated SWCNTs (single-(10,10)CNT, aggregated-7-(10,10)CNTs, and single-(35,35)CNT with the same diameter as that of the aggregated one) on the activity of dopamine-related proteins [tyrosine hydroxylase (TyrOH) and dopamine transporter (DAT), which are related to the synthesis and transport of dopamine, respectively]...
September 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28856500/methamphetamine-induced-brain-injury-and-alcohol-drinking
#8
Amanda L Blaker, Bryan K Yamamoto
A majority of methamphetamine (Meth) abusers also abuse alcohol but the neurochemical consequences of this co-abuse are unknown. Individually, alcohol and Meth cause inflammation and long-term alterations in dopamine and serotonin signaling within the brain. Experiments were conducted to identify if serial exposure to alcohol and Meth has neurochemical consequences that are greater than after either drug alone. Male Sprague Dawley rats voluntarily drank 10% ethanol (EtOH) every other day for 4 weeks and were then exposed to a binge injection regimen of Meth (10 mg/kg injected every 2 h, for a total of 4 injections)...
August 30, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28844119/the-role-of-hint1-in-methamphetamine-induced-conditioned-place-preference
#9
Ju-Ping Li, Peng Liu, Gang Lei, Zheng Chu, Fei Liu, Chao-Feng Shi, Yong-Hui Dang, Teng Chen
Drug addiction is a chronically relapsing disorder in humans; yet, the underlying mechanism remained unclear. Recent studies suggested that the histidine triad nucleotide binding protein 1 (HINT1) may play significant roles in diverse neuropsychiatric diseases including drug addiction. In our present study, we used different batches of mice to establish the different stages of methamphetamine (METH)-induced conditioned place preference (CPP) to explore the dynamic changes throughout the process of addiction in different brain regions, including prefrontal cortex (PFC), nucleus accumbens (NAc), corpus striatum (CPu), and hippocampus (Hip)...
August 26, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28842817/methamphetamine-induces-tet1-and-tet3-dependent-dna-hydroxymethylation-of-crh-and-avp-genes-in-the-rat-nucleus-accumbens
#10
Subramaniam Jayanthi, Betina Gonzalez, Michael T McCoy, Bruce Ladenheim, Veronica Bisagno, Jean Lud Cadet
Methamphetamine (METH) addiction is a biopsychosocial disorder that is accompanied by multiple relapses even after prolonged abstinence, suggesting the possibilities of long-lasting maladaptive epigenetic changes in the brain. Here, we show that METH administration produced time-dependent increases in the expression of corticotropin-releasing hormone (Crh/Crf), arginine vasopressin (Avp), and cocaine- and amphetamine-regulated transcript prepropeptide (Cartpt) mRNAs in the rat nucleus accumbens (NAc). Chromatin immunoprecipitation (ChIP) assays revealed that METH increased the abundance of phosphorylated CREB (pCREB) at the promoter of Cartpt but not at Avp or Crh DNA sequences...
August 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28842000/a-novel-colorimetric-biosensor-based-on-non-aggregated-au-ag-core-shell-nanoparticles-for-methamphetamine-and-cocaine-detection
#11
Kang Mao, Zhugen Yang, Junrong Li, Xiaodong Zhou, Xiqing Li, Jiming Hu
We report a novel colorimetric biosensor based on non-aggregation Au@Ag core-shell nanoparticles to detect methamphetamine and cocaine. The biosensor consisted of a reporter probe (RP) that is a specific single-stranded DNA (ssDNA) sequence coated on Au@Ag nanoparticles, a capture probe (CP) conjugated with magnetic beads, and an illicit drug-binding DNA aptamer (Apt). Au@Ag nanoparticles were synthesized by seed growth and characterized by scanning electron microscope (SEM), high-resolution transmission electron microscopy (HR-TEM), and UV-vis spectra...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28835159/increased-dna-methylation-in-the-parvalbumin-gene-promoter-is-associated-with-methamphetamine-dependence
#12
Siriluk Veerasakul, Paritat Watiktinkorn, Samur Thanoi, Caroline F Dalton, Helene A Fachim, Sutisa Nudmamud-Thanoi, Gavin P Reynolds
AIM: The parvalbumin (PV)-containing subgroup of GABAergic neurons is particularly affected in schizophrenia and animal models of psychosis, including after methamphetamine (METH) administration. We investigated whether METH dependence and METH-induced psychosis may involve an effect on DNA methylation of the PVALB promoter. MATERIALS & METHODS: The methylation of a PVALB promoter sequence was determined in 100 METH-dependent and 102 control subjects using pyrosequencing...
August 24, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28830220/exploring-strategies-for-prep-adherence-and-dosing-preferences-in-the-context-of-sexualized-recreational-drug-use-among-msm-a-qualitative-study
#13
Elizabeth F Closson, Jennifer A Mitty, Jowanna Malone, Kenneth H Mayer, Matthew J Mimiaga
The use of recreational drugs while having sex is associated with increased HIV incidence among men who have sex with men (MSM). Taking a daily antiretroviral pill, or pre-exposure prophylaxis (PrEP) is a biomedical intervention to prevent HIV. However, the efficacy of PrEP is closely tied with high levels of adherence. While PrEP has the potential to reduce HIV acquisition, the use of recreational drugs may impede adherence. We explored perceptions of PrEP utilization and regimen preferences among 40 HIV-negative, MSM who reported concurrent recreational drug use and condomless anal sex with a man...
August 22, 2017: AIDS Care
https://www.readbyqxmd.com/read/28819096/controlled-radical-fluorination-of-poly-meth-acrylic-acids-in-aqueous-solution
#14
Yucheng Dong, Zhentao Wang, Chaozhong Li
Fluorinated alkenes exhibit very poor reactivity in copolymerization with non-fluorinated polar monomers such as acrylates. Herein we describe a convenient method for the synthesis of poly(vinyl fluoride-co-acrylic acid) and poly(2-fluoropropene-co-methacrylic acid) copolymers. Thus, the silver-catalyzed decarboxylative radical fluorination of poly(acrylic acid) with Selectfluor in water at room temperature affords poly(vinyl fluoride-co-acrylic acid) copolymers in high yields with well-defined molecular weights and polydispersities...
August 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28802277/microbiome-in-lung-explants-of-idiopathic-pulmonary-fibrosis-a-case-control-study-in-patients-with-end-stage-fibrosis
#15
Georgios D Kitsios, Mauricio Rojas, Daniel J Kass, Adam Fitch, John C Sembrat, Shulin Qin, Kristen L Veraldi, Kevin F Gibson, Kathleen Lindell, Joseph M Pilewski, Barbara Methe, Kelvin Li, John McDyer, Bryan J McVerry, Alison Morris
The microbiome has been proposed to play a role in the progression of idiopathic pulmonary fibrosis (IPF) based on bronchoalveolar lavage analyses, but the microbiome of lung tissue in IPF has not been explored. In a case-control study of lung explants analysed by 16S rRNA gene sequencing, we could not reliably detect bacterial DNA in basilar tissue samples from patients with either chronic or acute exacerbations of IPF, in contrast to control candidate-donor lungs or cystic fibrosis explants. Thus, our data do not indicate microbiome alterations in regions of IPF lung with advanced fibrosis...
August 11, 2017: Thorax
https://www.readbyqxmd.com/read/28792619/corticosterone-and-exogenous-glucose-alter-blood-glucose-levels-neurotoxicity-and-vascular-toxicity-produced-by-methamphetamine
#16
John F Bowyer, Karen M Tranter, Sumit Sarkar, Nysia I George, Joseph P Hanig, Kimberly A Kelly, Lindsay T Michalovicz, Diane B Miller, James P O'Callaghan
Our previous studies have raised the possibility that altered blood glucose levels may influence and/or be predictive of methamphetamine (METH) neurotoxicity. This study evaluated the effects of exogenous glucose and corticosterone (CORT) pretreatment alone or in combination with METH on blood glucose levels and the neural and vascular toxicity produced. METH exposure consisted of four sequential injections of 5, 7.5, 10, and 10 mg/kg (2h between injections) D-METH. The three groups given METH in combination with saline, glucose (METH+Glucose), or CORT (METH+CORT) had significantly higher glucose levels compared to the corresponding treatment groups without METH except at 3 h after the last injection...
August 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28790056/alcoholic-versus-aqueous-chlorhexidine-for-skin-antisepsis-the-avalanche-trial
#17
RANDOMIZED CONTROLLED TRIAL
Daniel Charles, Clare F Heal, Meth Delpachitra, Michael Wohlfahrt, Debbie Kimber, Julie Sullivan, Sheldon Browning, Sabine Saednia, Alexandra Hardy, Jennifer Banks, Petra Buttner
BACKGROUND: Preoperative skin antisepsis is routine practice. We compared alcoholic chlorhexidine with aqueous chlorhexidine for skin antisepsis to prevent surgical site infection after minor skin excisions in general practice. METHODS: We conducted this prospective, multicentre, randomized controlled trial in 4 private general practices in North Queensland, Australia, from October 2015 to August 2016. Consecutive adult patients presenting for minor skin excisions were randomly assigned to undergo preoperative skin antisepsis with 0...
August 8, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28782589/the-role-of-thioredoxin-1-in-resisting-methamphetamine-induced-rewarding-effect
#18
Mengbing Huang, Lingpin Kong, Lihua Yang, Xiang Li, Xiaoshuang Zhou, Ye Li, Jie Bai
Methamphetamine (METH) is a highly addictive drug of abuse which induces behavioral sensitization and rewarding effects. Thioredoxin-1 (Trx-1) is a redox protein and plays role in regulating activity of transcription factor, such as cAMP responsive element-binding protein (CREB), AP-1, p53, is emerging as an important modulator of neuronal function. It has been reported that Trx-1 is involved in morphine dependence. In this study, we examined the rewarding effect after METH administration by conditioned place preference (CPP) of mice, and detected the levels of dopamine and the activity of cAMP responsive element-binding protein (CREB), the expressions of ΔFosB and cyclin-dependent kinase 5 (CDK5) in the ventral tegmental area (VTA) and nucleus accumbens (NAc) in mice...
August 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28771174/impact-of-the-hydration-states-of-polymers-on-their-hemocompatibility-for-medical-applications-a-review
#19
REVIEW
Min A Bag, Loreto M Valenzuela
Water has a key role in the functioning of all biological systems, it mediates many biochemical reactions, as well as other biological activities such as material biocompatibility. Water is often considered as an inert solvent, however at the molecular level, it shows different behavior when sorbed onto surfaces like polymeric implants. Three states of water have been recognized: non-freezable water, which does not freeze even at -100 °C; intermediate water, which freezes below 0 °C; and, free water, which freezes at 0 °C like bulk water...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28762183/novel-nanoformulation-to-mitigate-co-effects-of-drugs-of-abuse-and-hiv-1-infection-towards-the-treatment-of-neuroaids
#20
Rahul Dev Jayant, Venkata S R Atluri, Sneham Tiwari, Sudheesh Pilakka-Kanthikeel, Ajeet Kaushik, Adriana Yndart, Madhavan Nair
Drug abuse (e.g., methamphetamine-Meth or cocaine-Coc) is one of the major risk factors for becoming infected with HIV-1, and studies show that in combination, drug abuse and HIV-1 lead to significantly greater damage to CNS. To overcome these issues, we have developed a novel nanoformulation (NF) for drug-abusing population infected with HIV-1. In this work, a novel approach was developed for the co-encapsulation of Nelfinavir (Nel) and Rimcazole (Rico) using layer-by-layer (LbL) assembled magnetic nanoformulation for the cure of neuroAIDS...
July 31, 2017: Journal of Neurovirology
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