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Marta Skowronska, Marisa McDonald, Martina Velichkovska, Ana Rachel Leda, Minseon Park, Michal Toborek
HIV-1 infection and methamphetamine (METH) abuse frequently occur simultaneously and may have synergistic pathological effects. Although HIV-positive/active METH users have been shown to have higher HIV viral loads and experience more severe neurological complications than non-users, the direct impact of METH on HIV infection and its link to the development of neurocognitive alternations are still poorly understood. In the present study, we hypothesized that METH impacts HIV infection of neural progenitor cells (NPC) by a mechanism encompassing NFκB/SP1-mediated HIV-LTR activation...
November 20, 2017: Journal of Biological Chemistry
Sarju Adhikari, Yu Xia
Inspired by the high reactivity and specificity of thiyl radicals toward alkenes, we have developed a new charge derivatization method to enable fast and quantitative analysis of sterols via electrospray ionization-mass spectrometry (ESI-MS). Thioglycolic acid (TGA), a commercially available compound, has been established as a highly efficient tagging reagent. Initiated from photochemical reactions, the thiyl radical derived from TGA abstracts an allylic hydrogen in the B ring of sterols, forming a radical intermediate which rapidly recombines with a second thiyl radical to produce the final tagged product...
November 22, 2017: Analytical Chemistry
Le Tuan Anh, Alexander A Titov, Maxim S Kobzev, Leonid G Voskressensky, Alexey V Varlamov, Pavel V Dorovatovskii, Victor N Khrustalev
The title compound, C25H27NO4 (I), the product of the unusual thermolysis of aza-cyclic allene methyl 10,11-dimeth-oxy-3,8-dimethyl-6-phenyl-3-aza-benzo[d]cyclo-deca-4,6,7-triene-5-carboxyl-ate, represents a bicyclic heterosystem and crystallizes in the monoclinic space group P21/c with three crystallographically independent mol-ecules in the unit cell. These independent mol-ecules adopt very similar geometries and differ only in the conformations of the two meth-oxy substituents on the benzene ring. In two of the three independent mol-ecules, both meth-oxy groups are almost coplanar with the benzene ring [the C-C-O-Me torsion angles are 10...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Doaa M Masoud, Sherif F Hammad, Galal H Elgemeie, Peter G Jones
In the title compound, C14H18N2O5S, the C-S bond lengths are unequal, with S-Cglucose = 1.8016 (15) Å and S-Cpyrid-yl = 1.7723 (13) Å. The hydro-philic glucose residues lie in the regions z ≃ 0.25 and 0.75. Four classical hydrogen bonds link the mol-ecules to form layers parallel to the ab plane, from which the pyridyl rings project; pyridyl ring stacking parallel to the a axis links adjacent layers.
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Jesse Shooter, Caleb J Allen, Colby W K Tinsley, Lev N Zakharov, Eric R Abbey
The title compound [systematic name: 4-(di-methyl-amino)-pyridine-4-meth-oxy-phenyl-borane (1/1)], C14H19BN2O, contains two independent mol-ecules in the asymmetric unit. Both molecules exhibit coplanar, mostly sp(2)-hybridized meth-oxy and di-methyl-amino substituents on their respective aromatic rings, consistent with π-donation into the aromatic systems. The B-H groups exhibit an intra-molecular close contact with a C-H group of the pyridine ring, which may be evidence of electrostatic attraction between the hydridic B-H and the electropositive aromatic C-H...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Le Tuan Anh, Alexander A Titov, Reza Samavati, Leonid G Voskressensky, Alexey V Varlamov, Victor N Khrustalev
The title compound, C19H19NO5, (I), is the product of a domino reaction between cotarnine chloride and acetyl-acetylene catalysed by copper(I) iodide. The mol-ecule of (I) comprises a fused tetra-cyclic system containing two terminal five-membered rings (pyrrole and 1,3-dioxole) and two central six-membered rings (di-hydro-pyridine and benzene). The five-membered 1,3-dioxole ring has an envelope conformation and the central six-membered di-hydro-pyridine ring adopts a twist-boat conformation. The acyl substituent is almost coplanar with the pyrrole ring, whereas the meth-oxy substituent is twisted by 27...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Ugochukwu Okeke, Yilma Gultneh, Ray J Butcher
The title compound, [Cu2(ClO4)(C14H13N2O)2(H2O)]ClO4, crystallizes as an unsymmetrical dinuclear cation bridged by the phen-oxy O atoms with one Cu(II) atom coordinated by a water mol-ecule and the other by a perchlorate anion, thus making both Cu(II) atoms five-coordinate, and with a further perchlorate anion present for charge balance. A long inter-action [2.9893 (5) Å] between one of the two Cu(II) atoms and an O atom of the perchlorate counter-ion links the cations and anions into linear chains along the a-axis direction...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Anand Gupta, Harkesh B Singh, Ray J Butcher
In the mol-ecular structure of the title compound, {2,6-bis-[(di-methyl-amino)-meth-yl]phenyl-κ(3)N,C(1),N'}[bromido/chlorido-(0.30/0.70)]mercury(II)-{2,6-bis-[(di-methyl-amino)-meth-yl]phenyl-κ(3)N,C(1),N'}[bromido/chlorido-(0.24/0.76)]mer-cury(II) (1/1), [HgBr0.30Cl0.70(C12H19N2)]·[HgBr0.24Cl0.76(C12H19N2)], there are two mol-ecules in the asymmetric unit of formula LHgX {L = 2,6-bis-[(di-methyl-amino)-meth-yl]phenyl and X = Cl/Br}. In each mol-ecule, the halide site is mixed Cl/Br, with occupancies of 0...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Bhai R Devika, C R Girija, Suresh Shalini, Mukesh M Jotani, Edward R T Tiekink
The title zwitterion, C17H13NO2 (systematic name: 1-{(1E)-[(4-hy-droxy-phen-yl)iminium-yl]meth-yl}naphthalen-2-olate), features an intra-molecular charge-assisted N(+)-H⋯O(-) hydrogen bond. A twist in the mol-ecule is evident around the N-C(hy-droxy-benzene) bond [C-N-C-C torsion angle = 39.42 (8)°] and is reflected in the dihedral angle of 39.42 (8)° formed between the aromatic regions of the mol-ecule. In the crystal, zigzag supra-molecular chains along the a axis are formed by charge-assisted hy-droxy-O-H⋯O(phenoxide) hydrogen bonding...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Laura N F Cardoso, Thais C M Noguiera, Carlos R Kaiser, James L Wardell, Marcus V N de Souza, William T A Harrison
The syntheses and crystal structures of (E)-N'-(3-cyano-benzyl-idene)-N-methyl-2-(thio-phen-2-yl)acetohydrazide, C15H13N3OS, (I), and (E)-N'-(4-meth-oxy-benzyl-idene)-N-methyl-2-(thio-phen-2-yl)acetohydrazide, C15H16N2O2S, (II), with different substituents in the meta and para position of the benzene ring are described. Compounds (I) and (II) both crystallize with two mol-ecules in the asymmetric unit, with generally similar conformations [r.m.s. overlay fits for (I) and (II) of 0.334 and 0.280 Å, respectively] that approximate to L-shapes...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
David K Geiger, Matthew R DeStefano, Robert A Lewis
Copper(II) complexes of benzimidazole are known to exhibit biological activity that makes them of inter-est for chemotherapeutic and other pharmaceutical uses. The complex bis-(acetato-κO){5,6-dimethyl-2-(pyridin-2-yl)-1-[(pyridin-2-yl)meth-yl]-1H-benzimidazole-κ(2)N(2),N(3)}copper(II), has been prepared. The absorption spectrum has features attributed to intra-ligand and ligand-field transitions and the complex exhibits ligand-centered room-temperature luminescence in solution. The aceto-nitrile monosolvate, [Cu(C2H3O2)2(C20H18N4)]·C2H3N (1), and the ethanol hemisolvate, [Cu(C2H3O2)2(C20H18N4)]·0...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Delia Bautista, Sergio J Benitez-Benitez
The binuclear title complex, di-μ-iodido-bis(-{2-[(benzylamino-κN)meth-yl]phenyl-κC(1)}palladium(II)), [Pd2I2(C14H14N)2], was prepared by reaction of [Pd{C6H4(CH2NHCH2Ph)-2}(μ-OAc)]2 with NaI. It crystallizes with one discrete mol-ecule in the asymmetric unit. The mol-ecule presents an iodide-bridged dimeric structure with a cisoid arrangement with respect to the C,N-cyclo-palladated ligands. Both Pd(II) atoms have a slightly distorted square-planar coordination environment. Weak inter-molecular contacts of the type C-H⋯Pd seem to have a significant influence on the arrangement of the mol-ecules along the b axis in the crystal...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Ming Yueh Tan, Karen A Crouse, Thahira B S A Ravoof, Mukesh M Jotani, Edward R T Tiekink
The title compound, C23H21N3O2, is constructed about an almost planar disubstituted amino-urea residue (r.m.s. deviation = 0.0201 Å), which features an intra-molecular amine-N-H⋯N(imine) hydrogen bond. In the 'all-trans' chain connecting this to the terminal meth-oxy-benzene residue, the conformation about each of the imine and ethyl-ene double bonds is E. In the crystal, amide-N-H⋯O(carbon-yl) hydrogen bonds connect centrosymmetrically related mol-ecules into dimeric aggregates, which also incorporate ethyl-ene-C-H⋯O(amide) inter-actions...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Bartłomiej Witkowski, Anna Duchnowicz, Monika Ganeczko, Agnieszka Laudy, Tomasz Gierczak, Magdalena Biesaga
Simplified method for simultaneous identification of proteins, drying oils, waxes and resins in the works-of-art samples was developed. Liquid chromatography with mass spectrometry and gas chromatography with mass spectrometry were used to identify natural materials most frequently encountered in historical paintings. Protein binders were extracted with ammonia and purified using miniaturized solid-phase microextraction (Omix tips) to efficiently suppress matrix interferences. Zwitterionic stationary phase was used for separation of sixteen underivatized amino acids analysis with hydrophilic interaction liquid chromatography that were subsequently quantified with liquid chromatography with mass spectrometry...
November 18, 2017: Journal of Separation Science
Mao Chen, Honghong Gong, Yucheng Zhao, Xianwang Shen, Jun Lin
Fluorinated polymers are important materials that are widely used in many areas. Herein, we report the development of a metal-free photo-controlled radical polymerization of semi-fluorinated (meth)acrylates with a new visible light absorbing organocatalyst. This method allows the production of a variety of semi-fluorinated polymers with narrow molar weight distributions from semi-fluorinated trithiocarbonates or perfluoroalkyl iodide. The high performance of "ON/OFF" control and chain extension experiments further demonstrate the utility and reliability of this method...
November 14, 2017: Angewandte Chemie
Michael Saemisch, Markus Nickmann, Lisa Riesinger, Elazer R Edelman, Heiko Methe
The programmed form of cell death (apoptosis) is essential for normal development of multicellular organisms. Dysregulation of apoptosis has been linked with embryonal death and is involved in the pathophysiology of various diseases. Others and we previously demonstrated endothelial biology being intertwined with biochemical and structural composition of the subendothelial basement membrane. We now demonstrate that a three-dimensional growing environment significantly shields endothelial cells from cytokine-induced apoptosis...
November 13, 2017: Journal of Tissue Engineering and Regenerative Medicine
Sophia J Luikinga, Jee Hyun Kim, Christina J Perry
Most people that experience illicit drugs do so for the first time during adolescence, and methamphetamine (meth) is no exception. Therefore, research into the effects of meth should highlight the adolescent period. Despite this, the vast majority of current literature has mainly focused on meth exposure during adulthood. In this review, we first describe existing literature that compares the behavioral effects of meth where exposure occurs in adolescence compared to adulthood. Given that there are actually very few such studies, we also look at what is known about neural effects of meth in the adult brain, and relate these to normal neural development occurring during the adolescent period to establish how meth may target maturing regions and related neurochemistry...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
Xiao Shu, Qing Dai, Tong Wu, Ian R Bothwell, Yanan Yue, Zezhou Zhang, Jie Cao, Qili Fei, Minkui Luo, Chuan He, Jianzhao Liu
RNA labeling is crucial for the study of RNA structure and metabolism. Herein we report N(6)-allyladenosine (a(6)A) as a new small molecule for RNA labeling through both metabolic and enzyme-assisted manners. a(6)A behaves like A and can be metabolically incorporated into newly synthesized RNAs inside mammalian cells. We also show that human RNA N(6)-methyladenosine (m(6)A) methyltransferases METTL3/METTL14 can work with a synthetic cofactor, namely allyl-SAM (S-adenosyl methionine with methyl replaced by allyl) in order to site-specifically install an allyl group to the N(6)-position of A within specific sequence to generate a(6)A-labeled RNAs...
November 15, 2017: Journal of the American Chemical Society
Parag K Shah, Jeffrey W Stansbury, Christopher N Bowman
A new addition-fragmentation chain transfer (AFT) capable moiety was incorporated into a dimethacrylate monomer that participated readily in network formation by copolymerizing with multifunctional methacrylates or acrylates. The process of AFT occurred simultaneously with photopolymerization of the AFT monomer (AFM) and other (meth)acrylate monomers leading to polymer stress relaxation via network reconfiguration. At low loading levels of the AFM, a significant reduction in shrinkage stress, especially for acrylate monomers, was observed with nominal effects on conversion...
August 14, 2017: Polymer Chemistry
Yuzhong Wang, Hunter P Hickox, Yaoming Xie, Pingrong Wei, Henry F Schaefer, Gregory H Robinson
Reaction of thiolate 1 with carbene-stabilized diiodo-bis-silylene (2) (in a 2:1 ratio) in THF unexpectedly gives both the first five-membered, sulfur-containing, zwitterionic silylene ring (3) via insertion of the "Si(I)2" unit of 2 into the olefinic C-H bond of the imidazole ring of 1 and four-membered cyclic silylene (4) via insertion of a silicon(I) atom of 2 into the Cphenyl-N bond of the carbene ligand. The parallel reaction in toluene only gives 3 as the major product. The nature of the bonding in isomeric 3 and 4 was probed by experimental and theoretical methods...
November 15, 2017: Journal of the American Chemical Society
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