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https://www.readbyqxmd.com/read/27914155/-main-causes-of-occupational-allergic-contact-dermatitis-a-three-year-study-in-the-center-of-portugal
#1
Catarina Pestana, Raquel Gomes, Vítor Pinheiro, Miguel Gouveia, Isabel Antunes, Margarida Gonçalo
INTRODUCTION: Allergic contact dermatitis, along with irritant contact dermatitis and immediate contact reactions, contact urticarial, are the most frequent dermatological occupational disease, but seldom reported to the National authorities. MATERIAL AND METHODS: We performed a 3-year retrospective study at the allergology section in the Dermatology Clinic of the University Hospital of Coimbra to evaluate the main occupations diagnosed as occupational allergic contact dermatitis, most common allergens and the effect of the modification of the work station in the evolution of the disease...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27902717/could-google-trends-be-used-to-predict-methamphetamine-related-crime-an-analysis-of-search-volume-data-in-switzerland-germany-and-austria
#2
Alex Gamma, Roman Schleifer, Wolfgang Weinmann, Anna Buadze, Michael Liebrenz
OBJECTIVE: To compare the time trends of Google search interest in methamphetamine and criminal offences related to this drug. METHODS: Google Trends data for the search term "meth" was compared to methamphetamine-related crime statistics (incl. use, possession, and dealing) in Switzerland, Germany, and Austria for the years 2004-2016. Google data was availably monthly. Crime data was available yearly, and monthly values were imputed. RESULTS: On the country level, internet search trends for "meth" roughly paralleled relevant criminal activity...
2016: PloS One
https://www.readbyqxmd.com/read/27887830/drugs-of-abuse-and-their-metabolites-in-the-urban-rivers-of-beijing-china-occurrence-distribution-and-potential-environmental-risk
#3
Yan Zhang, Tingting Zhang, Changsheng Guo, Jiapei Lv, Zhendong Hua, Song Hou, Yuan Zhang, Wei Meng, Jian Xu
The occurrence and distribution of five drugs of abuse and their metabolites, namely, methamphetamine (METH), amphetamine (AMP), ketamine (KET), ephedrine (EPH), and hydroxylimine (HY), were investigated in the surface water in urban rivers in Beijing, China. A total of 117 surface water samples were collected from the seven rivers in the Beijing urban areas during four different seasons. Laboratory analyses revealed that EPH and METH were the most predominant drugs, with detection frequency ranging from 94% to 100% and from 65% to 100%, respectively...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27882750/-heart-attack-in-pregnancy
#4
T Výtisková, D Suchá, Z Fučíková
OBJECTIVE: To describe hear-attack on crystal meth addicted pregnant woman. DESIGN: Case report. CONCLUSION: Acute heart-attack during pregnancy means unexpected obstetric complication. The consequences could be fatal for the mother and the fetus. Although good delivery management and treatment could reduce morbidity and mortality to a minimum.
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27869204/mrna-changes-in-nucleus-accumbens-related-to-methamphetamine-addiction-in-mice
#5
Li Zhu, Jiaqi Li, Nan Dong, Fanglin Guan, Yufeng Liu, Dongliang Ma, Eyleen L K Goh, Teng Chen
Methamphetamine (METH) is a highly addictive psychostimulant that elicits aberrant changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the nucleus accumbens of mice, indicating a potential role of METH in post-transcriptional regulations. To decipher the potential consequences of these post-transcriptional regulations in response to METH, we performed strand-specific RNA sequencing (ssRNA-Seq) to identify alterations in mRNA expression and their alternative splicing in the nucleus accumbens of mice following exposure to METH...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866985/identification-of-functional-bitter-taste-receptors-and-their-antagonist-in-chickens
#6
Bapon Dey, Fuminori Kawabata, Yuko Kawabata, Yuta Yoshida, Shotaro Nishimura, Shoji Tabata
Elucidation of the taste sense of chickens is important not only for the development of chicken feedstuffs for the chicken industry but also to help clarify the evolution of the taste sense among animals. There are three putative chicken bitter taste receptors, chicken T2R1 (cT2R1), cT2R2 and cT2R7, which were identified using genome information and cell-based assays. Previously, we have shown that cT2R1 is a functional bitter taste receptor through both cell-based assays and behavioral tests. In this study, therefore, we focused on the sensitivities of the other two bitter receptors, cT2R2 and cT2R7, by using their agonists in behavioral tests...
November 17, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27854371/peculiarities-of-the-photoinitiator-free-photopolymerization-of-pentabrominated-and-pentafluorinated-aromatic-acrylates-and-methacrylates
#7
Olesya Daikos, Sergej Naumov, Wolfgang Knolle, Katja Heymann, Tom Scherzer
Pentabrominated and fluorinated aromatic (meth)acrylates as well as their non-halogenated counterparts have been studied with the aim to avoid conventional photoinitiators and to overcome some negative consequences related to their use. Therefore, RTIR spectroscopy, laser flash photolysis and GC/MS were utilized. Even low concentrations (1 to 5 wt%) of brominated (meth)acrylates in the model varnish lead to initiation of a photopolymerization reaction under exposure to UV light with λ > 300 nm. This is due to the fact that excitation of the aryl moiety leads to the homolysis of bromine-phenyl bonds with a high quantum yield of ∼0...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27846654/-synthetic-drugs-an-overview-of-important-and-newly-emerging-substances
#8
F Betzler, A Heinz, S Köhler
Background: Synthetic drug use and abuse are on the rise. Governmental institutions report a shift in consumption from natural drugs to synthetic drugs, and show an increase in confiscation, particularly of methamphetamine and newly identified psychoactive substances. In addition, the media report an alarming increase in the rate of consumption and casualties resulting from the use of drugs such as "crystal meth" and warn against a flood of this and other designer drugs from eastern European countries. Objectives: The present article gives an overview of current popular and widely used synthetic drugs, both classical substances (amphetamine, methamphetamine, MDMA) and new psychoactive substances ("designer drugs", "legal highs")...
November 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27844169/metabolic-engineering-of-escherichia-coli-w3110-for-the-production-of-l-methionine
#9
Hua Li, Bao Shi Wang, You Ran Li, Liang Zhang, Zhong Yang Ding, Zheng Hua Gu, Gui Yang Shi
In this study, we constructed an L-methionine-producing recombinant strain from wild-type Escherichia coli W3110 by metabolic engineering. To enhance the carbon flux to methionine and derepression met regulon, thrBC, lysA, and metJ were deleted in turn. Methionine biosynthesis obstacles were overcome by overexpression of metA (Fbr) (Fbr, Feedback resistance), metB, and malY under control of promoter pN25. Recombinant strain growth and methionine production were further improved by attenuation of metK gene expression through replacing native promoter by metK84p...
November 14, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27829367/intranasal-ketamine-for-acute-traumatic-pain-in-the-emergency-department-a-prospective-randomized-clinical-trial-of-efficacy-and-safety
#10
Shachar Shimonovich, Roy Gigi, Amir Shapira, Tal Sarig-Meth, Danielle Nadav, Mattan Rozenek, Debra West, Pinchas Halpern
BACKGROUND: Ketamine has been well studied for its efficacy as an analgesic agent. However, intranasal (IN) administration of ketamine has only recently been studied in the emergency setting. The objective of this study was to elucidate the efficacy and adverse effects of a sub-dissociative dose of IN Ketamine compared to IV and IM morphine. METHODS: A single-center, randomized, prospective, parallel clinical trial of efficacy and safety of IN ketamine compared to IV and IM morphine for analgesia in the emergency department (ED)...
November 9, 2016: BMC Emergency Medicine
https://www.readbyqxmd.com/read/27822269/the-effect-of-group-therapy-with-transactional-analysis-approach-on-emotional-intelligence-executive-functions-and-drug-dependency
#11
Masoomeh Forghani, Bahram Ali Ghanbari Hashem Abadi
OBJECTIVES: The aim of the present study was to evaluate the effect of group psychotherapy with transactional analysis (TA) approach on emotional intelligence (EI), executive functions and substance dependency among drug-addicts at rehabilitation centers in Mashhad city, Iran, in 2013. PATIENTS AND METHODS: In this quasi-experimental study with pretest, posttest, case- control stages, 30 patients were selected from a rehabilitation center and randomly divided into two groups...
June 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27799294/structure-activity-relationships-of-substituted-cathinones-with-transporter-binding-uptake-and-release
#12
Amy J Eshleman, Katherine M Wolfrum, John F Reed, Sunyoung O Kim, Tracy Swanson, Robert A Johnson, Aaron J Janowsky
Synthetic cathinones are components of "bath salts" and have physical and psychological side effects including hypertension, paranoia, and hallucinations. Herein we report interactions of 20 "bath salt" components with human dopamine, serotonin, and norepinephrine transporters (hDAT, hSERT, and hNET, respectively) heterologously expressed in HEK 293 cells. Transporter inhibitors had nanomolar to micromolar affinities (Ki values) at radioligand binding sites, with relative affinities of hDAT>hNET>hSERT for α-PPP, α-PBP, α-PHP, PV-8, 3,4-MDPPP, 3,4-MDPBP, 4-MePPP, α-PVP, 4-MeO- α-PVP, α-PVT and pentedrone, and hDAT>hSERT>hNET for pentylone...
October 31, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27788450/illicit-drug-use-among-gay-and-bisexual-men-in-44-cities-findings-from-the-european-msm-internet-survey-emis
#13
Axel J Schmidt, Adam Bourne, Peter Weatherburn, David Reid, Ulrich Marcus, Ford Hickson
BACKGROUND: Anecdotal evidence suggests that men who have sex with men (MSM) are increasingly combining sex and illicit drugs (an activity referred to as 'chemsex'), in particular GHB/GBL, ketamine, crystal meth, or mephedrone (here called 4-chems). Use of such drugs has been associated with mental health and sexual health harms. We aim to compare patterns of illicit drug use among MSM in 44 European urban centres. METHODS: In 2010, EMIS recruited 174,209 men from 38 countries to an anonymous online questionnaire in 25 languages...
October 24, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27784354/-effect-of-decitabine-in-combination-with-arsenic-trioxide-on-prolife-ration-and-apoptosis-of-human-acute-myeloid-leukemia-mv4-11-cells
#14
Si-Si Chen, Yan-Ping Zhao, Wen-Zhong Wu, Tie-Liang Ma, Su-Ning Chen
OBJECTIVE: To investigate the effect of decitabine (DAC) alone or in combination with arsenic trioxide (As2O3) on the proliferation and apoptosis of human acute myeloid leukemia (AML) MV4-11 cells, so as to find an effective method for treating AML with MLL rearrangements. METHODS: The inhibitory effect of DAC and As2O3 alone, as well as in a combination of less than 50% inhibitory concentration (IC50) of DAC, and with less than 20% inhibitory concentration (IC20) As2O3 on MV4-11 cell proliferation were detected by CCK-8 methed; and the apoptosis inducing effect was determined by flow cytometry...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27769482/polypeptide-with-electroactive-endgroups-as-sensing-platform-for-the-abused-drug-methamphetamine-by-bioelectrochemical-method
#15
Bilal Demir, Tulay Yilmaz, Emine Guler, Z Pinar Gumus, Huseyin Akbulut, Ebru Aldemir, Hakan Coskunol, Demet Goen Colak, Ioan Cianga, Shuhei Yamada, Suna Timur, Takeshi Endo, Yusuf Yagci
Affinity-type sensors have emerged as outstanding platforms in the detection of diagnostic protein markers, nucleic acids and drugs. Thus, these novel platforms containing antibodies could be integrated into the monitoring systems for abused drugs. Herein, we established a novel detection platform for the analysis of a common illicit drug; methamphetamine (METH). Initially, a fluorescent-labeled polypeptide (EDOT-BTDA-Pala), derived from L-alanine N-carboxyanhydride (L-Ala-NCA) via ring-opening polymerization using 4,7-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)benzo[c][1,2,5]thiadiazole-5,6-diamine (EDOT-NH2-BTDA) as initiator, was employed as a glassy carbon electrode (GCE) covering host, in order to immobilize the METH-selective antibody...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27768994/creating-visual-differences-methamphetamine-users-perceptions-of-anti-meth-campaigns
#16
Whitney Marsh, Heith Copes, Travis Linnemann
BACKGROUND: Because of increased law enforcement and subsequent media attention, methamphetamine users appear in the public's imagination as diseased, zombie-like White trash. We explore methamphetamine users' perceptions about whether the images, people, and situations in anti-methamphetamine campaigns reflect their own lives and experiences using meth. METHODS: To explore these perceptions, we used photo-elicitation interviews with 47 people who used methamphetamine (30 former and 17 active)...
October 18, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27767296/size-dependent-filling-behavior-of-uv-curable-di-meth-acrylate-resins-into-carbon-coated-anodic-aluminum-oxide-pores-of-around-20-nm
#17
Masaru Nakagawa, Akifumi Nakaya, Yasuto Hoshikawa, Shunya Ito, Nobuya Hiroshiba, Takashi Kyotani
Ultraviolet (UV) nanoimprint lithography is a promising nanofabrication technology with cost efficiency and high throughput for sub-20 nm size semiconductor, data storage, and optical devices. To test formability of organic resist mask patterns, we investigated whether the type of polymerizable di(meth)acrylate monomer affected the fabrication of cured resin nanopillars by UV nanoimprinting using molds with pores of around 20 nm. We used carbon-coated, porous, anodic aluminum oxide (AAO) films prepared by electrochemical oxidation and thermal chemical vapor deposition as molds, because the pore diameter distribution in the range of 10-40 nm was suitable for combinatorial testing to investigate whether UV-curable resins comprising each monomer were filled into the mold recesses in UV nanoimprinting...
October 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27763640/methamphetamine-potentiates-hiv-1-gp120-mediated-autophagy-via-beclin-1-and-atg5-7-as-a-pro-survival-response-in-astrocytes
#18
Lu Cao, Mingui Fu, Santosh Kumar, Anil Kumar
Methamphetamine (METH), a commonly used controlled substance, is known to exacerbate neuropathological dysfunction in HIV-infected individuals. The neuropathological manifestation results from cell death or dysfunction in the central nervous system (CNS) wherein autophagy is expected to have an important role. Autophagy is generally considered protective during deprivation/stress. However, excessive autophagy can be destructive, leading to autophagic cell death. This study was designed to investigate if METH and HIV-1 gp120 interact to induce autophagy in SVGA astrocytes, and whether autophagy is epiphenomenal or it has a role in METH- and gp120-induced cytotoxicity...
October 20, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27762079/methamphetamine-induces-anhedonic-like-behavior-and-impairs-frontal-cortical-energetics-in-mice
#19
Raquel Fonseca, Rui A Carvalho, Cristina Lemos, Ana C Sequeira, Inês R Pita, Fábio Carvalho, Carlos D Silva, Rui D S Prediger, Ivana Jarak, Rodrigo A Cunha, Carlos A Fontes Ribeiro, Attila Köfalvi, Frederico C Pereira
INTRODUCTION: We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless-like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown. AIMS: Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i...
October 19, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27760221/impaired-subset-progression-and-polyfunctionality-of-t-cells-in-mice-exposed-to-methamphetamine-during-chronic-lcmv-infection
#20
Uma Sriram, Beth L Hill, Jonathan M Cenna, Larisa Gofman, Nicole C Fernandes, Bijayesh Haldar, Raghava Potula
Methamphetamine (METH) is a widely used psychostimulant that severely impacts the host's innate and adaptive immune systems and has profound immunological implications. T cells play a critical role in orchestrating immune responses. We have shown recently how chronic exposure to METH affects T cell activation using a murine model of lymphocytic choriomeningitis virus (LCMV) infection. Using the TriCOM (trinary state combinations) feature of GemStone™ to study the polyfunctionality of T cells, we have analyzed how METH affected the cytokine production pattern over the course of chronic LCMV infection...
2016: PloS One
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