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https://www.readbyqxmd.com/read/29329371/alcohol-use-in-adolescence-and-later-working-memory-findings-from-a-large-population-based-birth-cohort
#1
Liam Mahedy, Matt Field, Suzanne Gage, Gemma Hammerton, Jon Heron, Matt Hickman, Marcus R Munafò
Aims: The study aimed to examine the association between adolescent alcohol use and working memory (WM) using a large population sample. Methods: Data from the Avon Longitudinal Study of Parents and Children were used to investigate the association between alcohol use at age 15 years and WM 3 years later, assessed using the N-back task (N ~ 3300). A three-category ordinal variable captured mutually exclusive alcohol groupings ranging in order of severity (i.e. low alcohol users, frequent drinkers and frequent/binge drinkers)...
January 10, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29316344/widespread-dynamic-and-pleiotropic-expression-of-the-melanocortin-1-receptor-mc1r-system-is-conserved-across-chick-mouse-and-human-embryonic-development
#2
Anna C Thomas, Pauline Heux, Chloe Santos, Wisenave Arulvasan, Nita Solanky, Magalie E Carey, Dianne Gerrelli, Veronica A Kinsler, Heather C Etchevers
BACKGROUND: MC1R, a G-protein coupled receptor with high affinity for alpha-melanocyte stimulating hormone (αMSH), modulates pigment production in melanocytes from many species and is associated with human melanoma risk. MC1R mutations affecting human skin and hair color also have pleiotropic effects on the immune response and analgesia. Variants affecting human pigmentation in utero alter the congenital phenotype of both oculocutaneous albinism and congenital melanocytic naevi, and have a possible effect on birthweight...
January 8, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29286930/hypoxic-ischemic-brain-injury-planned-delivery-before-intrapartum-events
#3
David Odd, Axel Heep, Karen Luyt, Tim Draycott
BACKGROUND: Mothers are increasingly given greater control over many of the choices around birth, although there is little robust evidence to inform these choices. After an infant is born with HIE the question of whether it was predictable, or preventable, is often raised. Intrapartum 'sentinel' events and antenatal predictors of HIE have been well described, however there is little evidence how antenatal and intrapartum factors interact. This is particularly important when elective delivery by lower segment caesarean section (LSCS) has been shown to be beneficial in high risk groups...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29260887/is-child-abuse-associated-with-adolescent-obesity-a-population-cohort-study
#4
Katherine Hawton, Tom Norris, Esther Crawley, Julian P H Shield
BACKGROUND: Child abuse is associated with obesity in adulthood through multiple mechanisms. However, little is known about the relationship between abuse and obesity during adolescence. The aim of this study was to investigate, using a birth cohort, whether there is an association between child abuse and overweight or obesity in adolescence. METHODS: This study utilizes data from the Avon Longitudinal Study of Parents and Children, a prospective cohort study based in South West England...
December 20, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/29242840/the-mid-childhood-and-adolescent-antecedents-of-women-s-external-locus-of-control-orientation
#5
Jean Golding, Steven Gregory, Yasmin Iles-Caven, Stephen Nowicki
Background: External locus of control orientation (ELOC) is a powerful predictor of adverse consequences in regard to health, educational attainment, inter-personal relationships and well-being. Although many cross-sectional studies have been carried out, relatively little is known about antecedent factors influencing the development of ELOC. Methods: Over 12,000 pregnant women who enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC) in south-west England, had completed a brief version of the Adult Nowicki-Strickland Internal-External LOC scale, together with detailed questions concerning their own parents and childhood...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29242670/reach-scale-river-metabolism-across-contrasting-sub-catchment-geologies-effect-of-light-and-hydrology
#6
Lorenzo Rovelli, Karl M Attard, Andrew Binley, Catherine M Heppell, Henrik Stahl, Mark Trimmer, Ronnie N Glud
We investigated the seasonal dynamics of in-stream metabolism at the reach scale (∼ 150 m) of headwaters across contrasting geological sub-catchments: clay, Greensand, and Chalk of the upper River Avon (UK). Benthic metabolic activity was quantified by aquatic eddy co-variance while water column activity was assessed by bottle incubations. Seasonal dynamics across reaches were specific for the three types of geologies. During the spring, all reaches were net autotrophic, with rates of up to 290 mmol C m-2 d-1 in the clay reach...
November 2017: Limnology and Oceanography
https://www.readbyqxmd.com/read/29237047/correlates-of-high-impact-physical-activity-measured-objectively-in-older-british-adults
#7
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark, Charlotte Moss, Mark H Edwards, Elaine Dennison, Tim Gaysin, Diana Kuh, Andrew Wong, Kenneth R Fox, Cyrus Cooper, Rachel Cooper, Jon H Tobias
Background: Exposure to higher magnitude vertical impacts is thought to benefit bone health. The correlates of this high-impact physical activity (PA) in later life are unknown. Methods: Participants were from the Cohort for Skeletal Health in Bristol and Avon, Hertfordshire Cohort Study and MRC National Survey of Health and Development. Associations of demographic, behavioural, physiological and psychological factors with vertical acceleration peaks ≥1.5 g (i...
December 11, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29207008/cannabis-use-and-hypomania-in-young-people-a-prospective-analysis
#8
Steven Marwaha, Catherine Winsper, Paul Bebbington, Daniel Smith
Background: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways. Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22-23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years...
November 28, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29203509/protocol-for-a-feasibility-study-and-randomised-pilot-trial-of-a-low-intensity-psychological-intervention-for-depression-in-adults-with-autism-the-autism-depression-trial-adept
#9
Ailsa Russell, Kate Cooper, Stephen Barton, Ian Ensum, Daisy Gaunt, Jeremy Horwood, Barry Ingham, David Kessler, Chris Metcalfe, Jeremy Parr, Dheeraj Rai, Nicola Wiles
INTRODUCTION: High rates of co-occurring depression are reported in autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social communication impairments and repetitive behaviours. Cognitive-behavioural interventions adapted for ASD have been effective for anxiety problems. There have been evaluation studies of group cognitive-behavioural therapy for co-occurring depression, but no randomised trials investigating low-intensity psychological interventions as recommended in clinical guidelines for mild-moderate depression...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29198208/association-between-childhood-infection-serum-inflammatory-markers-and-intelligence-findings-from-a-population-based-prospective-birth-cohort-study
#10
N Mackinnon, S Zammit, G Lewis, P B Jones, G M Khandaker
A link between infection, inflammation, neurodevelopment and adult illnesses has been proposed. The objective of this study was to examine the association between infection burden during childhood - a critical period of development for the immune and nervous systems - and subsequent systemic inflammatory markers and general intelligence. In the Avon Longitudinal Study of Parents and Children, a prospective birth cohort in England, we examined the association of exposure to infections during childhood, assessed at seven follow-ups between age 1·5 and 7·5 years, with subsequent: (1) serum interleukin 6 and C-reactive protein (CRP) levels at age 9; (2) intelligence quotient (IQ) at age 8...
December 4, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29171666/the-association-between-paternal-depressogenic-cognitive-styles-during-pregnancy-and-offspring-depressogenic-cognitive-styles-an-18-year-prospective-cohort-study
#11
Gemma Lewis, Siying Wen, Rebecca M Pearson, Glyn Lewis
BACKGROUND: Preventing the development of depressogenic or negative cognitive styles could also prevent the development of depression, a leading public health problem worldwide. Maternal negative cognitive styles are a modifiable risk factor for the development of negative cognitive styles in offspring. However, evidence on the role of paternal negative cognitive styles is inconclusive and there have only been a few small studies, which may also have lacked statistical power. METHODS: We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) to investigate the association between paternal negative cognitive styles, measured when mothers were 18 weeks pregnant, and offspring negative cognitive styles 18 years later (N = 6,123)...
November 24, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29162179/variation-in-dna-methylation-of-the-oxytocin-receptor-gene-predicts-children-s-resilience-to-prenatal-stress
#12
Izabela Milaniak, Charlotte A M Cecil, Edward D Barker, Caroline L Relton, Tom R Gaunt, Wendy McArdle, Sara R Jaffee
Emerging research in epigenetics has shown that there is variability in how environmental exposures "get under the skin" through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social-cognitive processes that may underlie a wide range of childhood psychopathology...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29147982/opportunity-mapping-of-natural-flood-management-measures-a-case-study-from-the-headwaters-of-the-warwickshire-avon
#13
Tom Lavers, Susanne Charlesworth
The use of natural flood management (NFM) measures to address severe flooding received considerable public attention during December 2015-January 2016 storms. Within the Warwickshire-Avon Catchment, UK, high arable and improved grassland land cover with small, isolated communities at risk, lead to the exploration of novel techniques that use farmland high up in flood-prone catchments to hold water and reduce outflow discharge. This paper will discuss the methodology used to identify areas in the Warwickshire-Avon, which could be used to install NFM measures to attenuate the storm peak and provide wider ecosystem services, principally addressing total phosphate and sediment entering the receiving watercourse...
November 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29135081/adverse-childhood-experiences-aces-and-adiposity-in-adolescents-a-cross-cohort-comparison
#14
Ana Luiza G Soares, Alicia Matijasevich, Ana M B Menezes, Maria Cecília Assunção, Fernando C Wehrmeister, Laura D Howe, Helen Gonçalves
OBJECTIVE: This study aimed to assess the association between adverse childhood experiences (ACEs) and adiposity in adolescents from two cohorts in different socioeconomic contexts. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) and the 1993 Pelotas Cohort (Brazil) were used. Six ACEs were assessed in both cohorts up to age 15. At 15 years, body mass index (BMI) and waist circumference (WC) were measured, and at 18 years, BMI, fat mass index, and android fat percentage were assessed...
November 14, 2017: Obesity
https://www.readbyqxmd.com/read/29134173/associations-of-lifetime-walking-and-weight-bearing-exercise-with-accelerometer-measured-high-impact-physical-activity-in-later-life
#15
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark, Charlotte Moss, Mark H Edwards, Elaine Dennison, Tim Gaysin, Diana Kuh, Andrew Wong, Kenneth R Fox, Cyrus Cooper, Rachel Cooper, Jon H Tobias
High impact physical activity (PA) is thought to benefit bone. We examined associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact and overall PA in later life. Data were from 848 participants (66.2% female, mean age = 72.4 years) from the Cohort for Skeletal Health in Bristol and Avon, Hertfordshire Cohort Study and MRC National Survey of Health and Development. Acceleration peaks from seven-day hip-worn accelerometer recordings were used to derive counts of high impact and overall PA...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29124294/the-relationship-between-financial-difficulty-and-childhood-symptoms-of-attention-deficit-hyperactivity-disorder-a-uk-longitudinal-cohort-study
#16
Abigail Emma Russell, Tamsin Ford, Ginny Russell
PURPOSE: Attention deficit/hyperactivity disorder (ADHD) is associated with socioeconomic status (SES), in that children who grow up in low SES families are at an increased risk of ADHD symptoms and diagnosis. The current study explores whether different levels of ADHD symptoms are associated with prior changes in the SES facet of financial difficulty. METHODS: Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined symptoms of ADHD measured by the Strengths and Difficulties Questionnaire (SDQ) hyperactivity subscale in relation to parent-reported changes in financial difficulty, grouped into four repeated measures at four time points across childhood; (n = 6416)...
November 9, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29122994/childhood-psychosocial-adversity-and-female-reproductive-timing-a-cohort-study-of-the-alspac-mothers
#17
Maria C Magnus, Emma L Anderson, Laura D Howe, Carol J Joinson, Ian S Penton-Voak, Abigail Fraser
BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children...
January 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29106580/physical-activity-phenotyping-with-activity-bigrams-and-their-association-with-bmi
#18
Louise A C Millard, Kate Tilling, Debbie A Lawlor, Peter A Flach, Tom R Gaunt
Background: Analysis of physical activity usually focuses on a small number of summary statistics derived from accelerometer recordings: average counts per minute and the proportion of time spent in moderate-vigorous physical activity or in sedentary behaviour. We show how bigrams, a concept from the field of text mining, can be used to describe how a person's activity levels change across (brief) time points. These variables can, for instance, differentiate between two people spending the same time in moderate activity, where one person often stays in moderate activity from one moment to the next and the other does not...
December 1, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29102868/associations-of-adversity-in-childhood-and-risk-factors-for-cardiovascular-disease-in-mid-adulthood
#19
Emma L Anderson, Abigail Fraser, Rishi Caleyachetty, Rebecca Hardy, Debbie A Lawlor, Laura D Howe
Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N=3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood...
November 2, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29100628/developmental-changes-within-the-genetic-architecture-of-social-communication-behavior-a-multivariate-study-of-genetic-variance-in-unrelated-individuals
#20
Beate St Pourcain, Lindon J Eaves, Susan M Ring, Simon E Fisher, Sarah Medland, David M Evans, George Davey Smith
BACKGROUND: Recent analyses of trait-disorder overlap suggest that psychiatric dimensions may relate to distinct sets of genes that exert maximum influence during different periods of development. This includes analyses of social communication difficulties that share, depending on their developmental stage, stronger genetic links with either autism spectrum disorder or schizophrenia. We developed a multivariate analysis framework in unrelated individuals to model directly the developmental profile of genetic influences contributing to complex traits, such as social communication difficulties, during an approximately 10-year period spanning childhood and adolescence...
September 28, 2017: Biological Psychiatry
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