Read by QxMD icon Read

Avon study

Helen Bould, Bianca De Stavola, Glyn Lewis, Nadia Micali
Previous research on eating disorders, disordered eating behaviours, and whether their prevalence varies across schools, has produced inconsistent results. Our previous work using Swedish record-linkage data found that rates of diagnosed eating disorders vary between schools, with higher proportions of girls and higher proportions of highly educated parents within a school being associated with greater numbers of diagnosed eating disorders. We aimed to extend these findings to a UK population-based sample and hypothesised that a similar association would be evident when studying disordered eating behaviours...
March 15, 2018: European Child & Adolescent Psychiatry
Maria C Mora-Pinzon, Amy Trentham-Dietz, Ronald E Gangnon, Scott V Adams, John M Hampton, Elizabeth Burnside, Martin M Shafer, Polly A Newcomb
PURPOSE: Heavy metals and other elements may act as breast carcinogens due to estrogenic activity. We investigated associations between urine concentrations of a panel of elements and breast density. METHODS: Mammographic density categories were abstracted from radiology reports of 725 women aged 40-65 yr in the Avon Army of Women. A panel of 27 elements was quantified in urine using high resolution magnetic sector inductively coupled plasma mass spectrometry. We applied LASSO (least absolute shrinkage and selection operator) logistic regression to the 27 elements and calculated odds ratios (OR) and 95% confidence intervals (CI) for dense vs...
March 14, 2018: Nutrition and Cancer
Eoin McElroy, Mark Shevlin, Jamie Murphy, Orla McBride
The network approach suggests that psychopathology arises from complex associations between symptoms and may offer insight into the mechanisms that underpin psychiatric comorbidities. The transition from childhood to adolescence is a key period in the development of psychopathology, yet has rarely been considered from a network perspective. As such, the present study examined the network structure of internalizing and externalizing psychopathology from middle childhood through adolescence using data from the Avon Longitudinal Study of Parents and Children (ALSPAC; n = 4405)...
March 8, 2018: European Child & Adolescent Psychiatry
Erin C Dunn, Katherine M Crawford, Thomas W Soare, Katherine S Button, Miriam R Raffeld, Andrew D A C Smith, Ian S Penton-Voak, Marcus R Munafò
BACKGROUND: Emotion recognition skills are essential for social communication. Deficits in these skills have been implicated in mental disorders. Prior studies of clinical and high-risk samples have consistently shown that children exposed to adversity are more likely than their unexposed peers to have emotion recognition skills deficits. However, only one population-based study has examined this association. METHODS: We analyzed data from children participating in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort (n = 6,506)...
March 7, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Michelle Taylor, Line Rode, Johan Bjørngaard, Amy E Taylor, Stig E Bojesen, Bjørn O Åsvold, Maiken E Gabrielsen, Glyn Lewis, Børge G Nordestgaard, Pål R Romundstad, Matthew Hickman, Marcus R Munafò
Background: Observational studies have shown that tobacco and alcohol use co-occur, but it is not clear whether this relationship is causal. Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK Biobank, we used observational methods to test the hypothesis that smoking heaviness increases alcohol consumption. Mendelian randomization (MR) analyses were then used to test the causal relationship between smoking heaviness and alcohol consumption using 55 967 smokers from four European studies [ALSPAC, The Nord-Trøndelag Health Study (HUNT), the Copenhagen General Population Study (CGPS) and UK Biobank]...
March 2, 2018: International Journal of Epidemiology
Barbara Torlinska, Sarah C Bath, Aisha Janjua, Kristien Boelaert, Shiao-Yng Chan
Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild-to-moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss...
March 1, 2018: Nutrients
Becky Mars, Jon Heron, E David Klonsky, Paul Moran, Rory C O'Connor, Kate Tilling, Paul Wilkinson, David Gunnell
BACKGROUND: Only one-third of young people who experience suicidal ideation attempt suicide. It is important to identify factors which differentiate those who attempt suicide from those who experience suicidal ideation but do not act on these thoughts. METHODS: Participants were 4,772 members of the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK population-based birth cohort. Suicide ideation and attempts were assessed at age 16 years via self-report questionnaire...
March 1, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Erin C Dunn, Thomas W Soare, Miriam R Raffeld, Daniel S Busso, Katherine M Crawford, Kathryn A Davis, Virginia A Fisher, Natalie Slopen, Andrew D A C Smith, Henning Tiemeier, Ezra S Susser
BACKGROUND: Although childhood adversity is a potent determinant of psychopathology, relatively little is known about how the characteristics of adversity exposure, including its developmental timing or duration, influence subsequent mental health outcomes. This study compared three models from life course theory (recency, accumulation, sensitive period) to determine which one(s) best explained this relationship. METHODS: Prospective data came from the Avon Longitudinal Study of Parents and Children (n = 7476)...
February 26, 2018: Psychological Medicine
Scott M Nelson, Caroline Haig, Alex McConnachie, Naveed Sattar, Susan M Ring, George D Smith, Debbie A Lawlor, Robert S Lindsay
OBJECTIVE: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. DESIGN: Prospective cohort study. SETTING: Avon Longitudinal Study of Parents and Children cohort in the UK. PARTICIPANTS: 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12). EXPOSURES: Free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function...
February 20, 2018: BMJ: British Medical Journal
Alison Teyhan, Dinithi Wijedasa, John Macleod
OBJECTIVE: To investigate whether men and women who were looked-after (in public care) or adopted as children are at increased risk of adverse psychological and social outcomes in adulthood. DESIGN, SETTING: Prospective observational study using the Avon Longitudinal Study of Parents and Children, which recruited pregnant women and their male partners in and around Bristol, UK in the early 1990s. PARTICIPANTS: 8775 women and 3654 men who completed questionnaires at recruitment (mean age: women 29; men 32) and 5 years later...
February 8, 2018: BMJ Open
Slava Dantchev, Stanley Zammit, Dieter Wolke
BACKGROUND: Being bullied by a sibling has been recently identified as a potential risk factor for developing depression and self-harm. It is unknown whether this risk extends to other serious mental health problems such as psychosis. We investigated whether sibling bullying victimization or perpetration in middle childhood was prospectively associated with psychotic disorder in early adulthood. METHODS: The current study investigated 6988 participants of the Avon Longitudinal Study of Parents and Children, a UK community-based birth cohort...
February 12, 2018: Psychological Medicine
John Gulliver, Paul Elliott, John Henderson, Anna L Hansell, Danielle Vienneau, Yutong Cai, Adrienne McCrea, Kevin Garwood, Andy Boyd, Lucy Neal, Paul Agnew, Daniela Fecht, David Briggs, Kees de Hoogh
We established air pollution modelling to study particle (PM10) exposures during pregnancy and infancy (1990-1993) through childhood and adolescence up to age ~15 years (1991-2008) for the Avon Longitudinal Study of Parents And Children (ALSPAC) birth cohort. For pregnancy trimesters and infancy (birth to 6 months; 7 to 12 months) we used local (ADMS-Urban) and regional/long-range (NAME-III) air pollution models, with a model constant for local, non-anthropogenic sources. For longer exposure periods (annually and the average of birth to age ~8 and to age ~15 years to coincide with relevant follow-up clinics) we assessed spatial contrasts in local sources of PM10 with a yearly-varying concentration for all background sources...
January 28, 2018: Environment International
Tim Morris, David Manley, Maarten Van Ham
Neighbourhood effects studies have demonstrated an association between area deprivation and smoking behaviour whereby people living in deprived neighbourhoods are more likely to smoke than those in non-deprived neighbourhoods. This evidence though is based largely upon data that ignores long term exposures to neighbourhood contexts and is confounded by neighbourhood selection bias. In this study, we investigate the temporal ordering of exposure to neighbourhood deprivation throughout childhood and whether associations between neighbourhood deprivation and cigarette smoking are due to compositional or contextual neighbourhood effects...
2018: PloS One
Jeanne E Savage, Jessica E Salvatore, Fazil Aliev, Alexis C Edwards, Matthew Hickman, Kenneth S Kendler, John Macleod, Antti Latvala, Anu Loukola, Jaakko Kaprio, Richard J Rose, Grace Chan, Victor Hesselbrock, Bradley T Webb, Amy Adkins, Tim B Bigdeli, Brien P Riley, Danielle M Dick
BACKGROUND: Despite consistent evidence of the heritability of alcohol use disorders (AUDs), few specific genes with an etiological role have been identified. It is likely that AUDs are highly polygenic; however, the etiological pathways and genetic variants involved may differ between populations. The aim of this study was thus to evaluate whether aggregate genetic risk for AUDs differed between clinically ascertained and population-based epidemiological samples. METHODS: Four independent samples were obtained: 2 from unselected birth cohorts (Avon Longitudinal Study of Parents and Children [ALSPAC], N = 4,304; FinnTwin12 [FT12], N = 1,135) and 2 from families densely affected with AUDs, identified from treatment-seeking patients (Collaborative Study on the Genetics of Alcoholism, N = 2,097; Irish Affected Sib Pair Study of Alcohol Dependence, N = 706)...
February 5, 2018: Alcoholism, Clinical and Experimental Research
Elena Netsi, Rebecca M Pearson, Lynne Murray, Peter Cooper, Michelle G Craske, Alan Stein
Importance: Maternal postnatal depression (PND) is common and associated with adverse child outcomes. These effects are not inevitable, and it is critical to identify those most at risk. Previous work suggests that the risks of adverse outcomes are increased when PND is severe and persistent, but this has not been systematically studied. Objective: To examine the association between differing levels of persistence and severity of PND and long-term child outcomes...
January 31, 2018: JAMA Psychiatry
Josephine Mollon, Anthony S David, Stanley Zammit, Glyn Lewis, Abraham Reichenberg
Importance: Most patients with psychotic disorders experience severe cognitive impairment, but the onset and course of this impairment remain unclear. Moreover, the course of cognitive functions in other psychiatric conditions remains largely unexamined. Objective: To chart the course of general and specific cognitive functions in individuals with psychotic disorders, psychotic experiences, and depression. Design, Setting, and Participants: The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective cohort study comprising all live births between April 1, 1991, and December 31, 1992, in Avon, England...
January 31, 2018: JAMA Psychiatry
Simon M Collin, Tom Norris, Kevin C Deere, Russell Jago, Andy R Ness, Esther Crawley
OBJECTIVE: To investigate associations of physical activity at age 11 years with chronic disabling fatigue (CDF) at ages 13 and 16 years. DESIGN: Longitudinal birth cohort. SETTING: South-West England. PARTICIPANTS: Adolescents enrolled in the Avon Longitudinal Study of Parents and Children. OUTCOMES AND EXPOSURES: We identified adolescents who had disabling fatigue of >6 months' duration without a known cause at ages 13 and 16 years...
January 30, 2018: Archives of Disease in Childhood
Steve Humphries, Marta Futema, Jackie Cooper, Marietta Charakida, Chris Boustred, Naveed Sattar, John Deanfield, Debbie Lawlor, Nick Timpson, Aroon Hingorani
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Rebecca B Lawn, Emma L Anderson, Matthew Suderman, Andrew J Simpkin, Tom R Gaunt, Andrew E Teschendorff, Martin Widschwendter, Rebecca Hardy, Diana Kuh, Caroline L Relton, Laura D Howe
Psychosocial adversity in childhood (e.g. abuse) and low socioeconomic position (SEP) can have significant lasting effects on social and health outcomes. DNA methylation-based biomarkers are highly correlated with chronological age; departures of methylation-predicted age from chronological age can be used to define a measure of age acceleration, which may represent a potential biological mechanism linking environmental exposures to later health outcomes. Using data from two cohorts of women (the Avon Longitudinal Study of Parents and Children, ALSPAC, N = 989 and MRC National Survey of Health and Development, NSHD, N = 773), we assessed associations of SEP, psychosocial adversity in childhood (parental physical or mental illness or death, parental separation, parental absence, sub-optimal maternal bonding, sexual, emotional and physical abuse and neglect) and a cumulative score of these psychosocial adversity measures, with DNA methylation age acceleration in adulthood (measured in peripheral blood at mean chronological ages 29 and 47 in ALSPAC and buccal cells at age 53 in NSHD)...
January 22, 2018: Human Molecular Genetics
A Mesut Erzurumluoglu, Denis Baird, Tom G Richardson, Nicholas J Timpson, Santiago Rodriguez
Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is still Y-DNA haplogroup variation which will result from population history. Therefore, hidden stratification and/or differential phenotypic effects by Y-DNA haplogroups could exist. To test this, we hypothesised that stratifying individuals according to their Y-DNA haplogroups before testing for associations between autosomal single nucleotide polymorphisms (SNPs) and phenotypes will yield difference in association...
January 22, 2018: Genes
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"