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Avon study

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https://www.readbyqxmd.com/read/29162179/variation-in-dna-methylation-of-the-oxytocin-receptor-gene-predicts-children-s-resilience-to-prenatal-stress
#1
Izabela Milaniak, Charlotte A M Cecil, Edward D Barker, Caroline L Relton, Tom R Gaunt, Wendy McArdle, Sara R Jaffee
Emerging research in epigenetics has shown that there is variability in how environmental exposures "get under the skin" through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social-cognitive processes that may underlie a wide range of childhood psychopathology...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29147982/opportunity-mapping-of-natural-flood-management-measures-a-case-study-from-the-headwaters-of-the-warwickshire-avon
#2
Tom Lavers, Susanne Charlesworth
The use of natural flood management (NFM) measures to address severe flooding received considerable public attention during December 2015-January 2016 storms. Within the Warwickshire-Avon Catchment, UK, high arable and improved grassland land cover with small, isolated communities at risk, lead to the exploration of novel techniques that use farmland high up in flood-prone catchments to hold water and reduce outflow discharge. This paper will discuss the methodology used to identify areas in the Warwickshire-Avon, which could be used to install NFM measures to attenuate the storm peak and provide wider ecosystem services, principally addressing total phosphate and sediment entering the receiving watercourse...
November 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29135081/adverse-childhood-experiences-aces-and-adiposity-in-adolescents-a-cross-cohort-comparison
#3
Ana Luiza G Soares, Alicia Matijasevich, Ana M B Menezes, Maria Cecília Assunção, Fernando C Wehrmeister, Laura D Howe, Helen Gonçalves
OBJECTIVE: This study aimed to assess the association between adverse childhood experiences (ACEs) and adiposity in adolescents from two cohorts in different socioeconomic contexts. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) and the 1993 Pelotas Cohort (Brazil) were used. Six ACEs were assessed in both cohorts up to age 15. At 15 years, body mass index (BMI) and waist circumference (WC) were measured, and at 18 years, BMI, fat mass index, and android fat percentage were assessed...
November 14, 2017: Obesity
https://www.readbyqxmd.com/read/29134173/associations-of-lifetime-walking-and-weight-bearing-exercise-with-accelerometer-measured-high-impact-physical-activity-in-later-life
#4
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark, Charlotte Moss, Mark H Edwards, Elaine Dennison, Tim Gaysin, Diana Kuh, Andrew Wong, Kenneth R Fox, Cyrus Cooper, Rachel Cooper, Jon H Tobias
High impact physical activity (PA) is thought to benefit bone. We examined associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact and overall PA in later life. Data were from 848 participants (66.2% female, mean age = 72.4 years) from the Cohort for Skeletal Health in Bristol and Avon, Hertfordshire Cohort Study and MRC National Survey of Health and Development. Acceleration peaks from seven-day hip-worn accelerometer recordings were used to derive counts of high impact and overall PA...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29124294/the-relationship-between-financial-difficulty-and-childhood-symptoms-of-attention-deficit-hyperactivity-disorder-a-uk-longitudinal-cohort-study
#5
Abigail Emma Russell, Tamsin Ford, Ginny Russell
PURPOSE: Attention deficit/hyperactivity disorder (ADHD) is associated with socioeconomic status (SES), in that children who grow up in low SES families are at an increased risk of ADHD symptoms and diagnosis. The current study explores whether different levels of ADHD symptoms are associated with prior changes in the SES facet of financial difficulty. METHODS: Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined symptoms of ADHD measured by the Strengths and Difficulties Questionnaire (SDQ) hyperactivity subscale in relation to parent-reported changes in financial difficulty, grouped into four repeated measures at four time points across childhood; (n = 6416)...
November 9, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29122994/childhood-psychosocial-adversity-and-female-reproductive-timing-a-cohort-study-of-the-alspac-mothers
#6
Maria C Magnus, Emma L Anderson, Laura D Howe, Carol J Joinson, Ian S Penton-Voak, Abigail Fraser
BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children...
November 9, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29106580/physical-activity-phenotyping-with-activity-bigrams-and-their-association-with-bmi
#7
Louise A C Millard, Kate Tilling, Debbie A Lawlor, Peter A Flach, Tom R Gaunt
Background: Analysis of physical activity usually focuses on a small number of summary statistics derived from accelerometer recordings: average counts per minute and the proportion of time spent in moderate-vigorous physical activity or in sedentary behaviour. We show how bigrams, a concept from the field of text mining, can be used to describe how a person's activity levels change across (brief) time points. These variables can, for instance, differentiate between two people spending the same time in moderate activity, where one person often stays in moderate activity from one moment to the next and the other does not...
June 29, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29102868/associations-of-adversity-in-childhood-and-risk-factors-for-cardiovascular-disease-in-mid-adulthood
#8
Emma L Anderson, Abigail Fraser, Rishi Caleyachetty, Rebecca Hardy, Debbie A Lawlor, Laura D Howe
Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N=3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood...
November 2, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29100628/developmental-changes-within-the-genetic-architecture-of-social-communication-behavior-a-multivariate-study-of-genetic-variance-in-unrelated-individuals
#9
Beate St Pourcain, Lindon J Eaves, Susan M Ring, Simon E Fisher, Sarah Medland, David M Evans, George Davey Smith
BACKGROUND: Recent analyses of trait-disorder overlap suggest that psychiatric dimensions may relate to distinct sets of genes that exert maximum influence during different periods of development. This includes analyses of social communication difficulties that share, depending on their developmental stage, stronger genetic links with either autism spectrum disorder or schizophrenia. We developed a multivariate analysis framework in unrelated individuals to model directly the developmental profile of genetic influences contributing to complex traits, such as social communication difficulties, during an approximately 10-year period spanning childhood and adolescence...
September 28, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29098496/partitioning-phenotypic-variance-due-to-parent-of-origin-effects-using-genomic-relatedness-matrices
#10
Charles Laurin, Gabriel Cuellar-Partida, Gibran Hemani, George Davey Smith, Jian Yang, David M Evans
We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals' phased genotypes. Genome-wide SNP data from parent child duos or trios is required to obtain relatedness matrices indexing the parental origin of offspring alleles, as well as offspring phenotype data to partition the trait variation into variance components...
November 2, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29097430/temporal-stability-of-multitrigger-and-episodic-viral-wheeze-in-early-childhood
#11
Ben D Spycher, Cara Cochrane, Raquel Granell, Jonathan A C Sterne, Michael Silverman, Eva Pedersen, Erol A Gaillard, John Henderson, Claudia E Kuehni
The distinction between episodic viral wheeze (EVW) and multitrigger wheeze (MTW) is used to guide management of preschool wheeze. It has been questioned whether these phenotypes are stable over time. We examined the temporal stability of MTW and EVW in two large population-based cohorts.We classified children from the Avon Longitudinal Study of Parents and Children (n=10 970) and the Leicester Respiratory Cohorts ((LRCs), n=3263) into EVW, MTW and no wheeze at ages 2, 4 and 6 years based on parent-reported symptoms...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29093763/maternal-eating-disorders-affect-offspring-cord-blood-dna-methylation-a-prospective-study
#12
Nabila Kazmi, Tom R Gaunt, Caroline Relton, Nadia Micali
Background: Eating disorders (ED) are chronic psychiatric disorders, common amongst women of reproductive age. ED in pregnancy are associated with poor nutrition and abnormal intrauterine growth. Increasing evidence also shows offspring of women with ED have adverse developmental and birth outcomes. We sought to carry out the first study investigating DNA methylation in offspring of women with ED. We compared cord blood DNA methylation in offspring of women with active ED (n = 21), past ED (n = 43) and age- and social class-matched controls (n = 126) as part of the Avon Longitudinal Study of Parents and Children...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29080482/the-impact-of-developmental-coordination-disorder-on-educational-achievement-in-secondary-school
#13
Ian Harrowell, Linda Hollén, Raghu Lingam, Alan Emond
BACKGROUND: Developmental coordination disorder (DCD) is a common developmental disorder but its long term impact on health and education are poorly understood. AIM: To assess the impact of DCD diagnosed at 7 years, and co-occurring developmental difficulties, on educational achievement at 16 years. METHODS: A prospective cohort study using data from the Avon Longitudinal Study of Parents and Children (ALSPAC). National General Certificate of Secondary Education (GCSE) exam results and Special Educational Needs provision were compared for adolescents with DCD (n=284) and controls (n=5425)...
October 25, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29074331/intra-individual-variability-and-psychotic-like-experiences-in-adolescents-findings-from-the-alspac-cohort
#14
Simon Wallace, Richard J Linscott
Clinical and epidemiological studies have demonstrated associations between elevated intra-individual variability (IIV) of reaction time and psychotic disorders. However, little attention has been paid to the relationship between performance stability and psychotic-like experiences (PLE) in adolescence, before psychotic disorder onset. Data from 6702 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to address this issue. Children took part in a semi-structured clinical interview regarding psychotic symptoms at age 12 and 18, and reaction time variability was assessed at age 13 and 15...
October 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29066395/associations-between-prenatal-childhood-and-adolescent-stress-and-variations-in-white-matter-properties-in-young-men
#15
REVIEW
Sarah K G Jensen, Melissa Pangelinan, Lassi Björnholm, Anja Klasnja, Alexander Leemans, Mark Drakesmith, C J Evans, Edward D Barker, Tomáš Paus
OBJECTIVE: Previous studies have shown that both pre- and post-natal adversities, the latter including exposures to stress during childhood and adolescence, explain variation in structural properties of white matter (WM) in the brain. While previous studies have examined effects of independent stress exposures within one developmental period, such as childhood, we examine effects of stress across development using data from a prospective longitudinal study. More specifically, we ask how stressful events during prenatal development, childhood, and adolescence relate to variation in WM properties in early adulthood in young men recruited from a birth cohort...
October 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29058116/longitudinal-associations-of-social-cognition-and-substance-use-in-childhood-and-early-adolescence-findings-from-the-avon-longitudinal-study-of-parents-and-children
#16
Meg E Fluharty, Jon Heron, Marcus R Munafò
Substance use is associated with impaired social cognition. Experimental studies have shown that acute intoxication of alcohol, tobacco, and cannabis decreases the performance in non-verbal, social communication and theory of mind tasks. However, in epidemiological studies the temporal direction of this association has gone relatively unstudied. We investigated both directions of association within an adolescent birth cohort: the association of social cognition with subsequent substance use, and the association of early substance use with subsequent social cognition...
October 20, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29046734/epigenome-wide-association-study-of-asthma-and-wheeze-in-childhood-and-adolescence
#17
Ryan Arathimos, Matthew Suderman, Gemma C Sharp, Kimberley Burrows, Raquel Granell, Kate Tilling, Tom R Gaunt, John Henderson, Susan Ring, Rebecca C Richmond, Caroline L Relton
BACKGROUND: Asthma heritability has only been partially explained by genetic variants and is known to be sensitive to environmental factors, implicating epigenetic modifications such as DNA methylation in its pathogenesis. METHODS: Using data collected in the Avon Longitudinal Study of Parents and Children (ALSPAC), we assessed associations of asthma and wheeze with DNA methylation at 7.5 and 16.5 years, at over 450,000 CpG sites in DNA from the peripheral blood of approx...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29046373/o-brother-where-art-thou-investment-in-siblings-for-inclusive-fitness-benefits-not-father-absence-predicts-earlier-age-at-menarche
#18
Daniel Smith
Numerous studies have indicated that father absence is associated with earlier age at menarche, with many evolutionary theories assuming that father absence is a causal factor that accelerates reproductive development. However, an alternative interpretation suggests that offspring may reproduce earlier in the presence of half- or step-siblings as the indirect fitness benefits to investing in them are lower, relative to delaying reproduction and investing in full siblings. From this perspective, father absence may perform no causal role in facilitating the onset of menarche...
October 2017: Biology Letters
https://www.readbyqxmd.com/read/29040503/the-role-of-early-life-growth-development-the-fto-gene-and-exclusive-breastfeeding-on-child-bmi-trajectories
#19
Yan Yan Wu, Stephen Lye, Laurent Briollais
Background: Recent studies have implicated the FTO gene in child and adult obesity. A longer duration of exclusive breastfeeding (EXBF) has been shown to reduce body mass index (BMI) and the risk of being overweight in the general population and among FTO gene carriers. However, it remains unclear whether the preventive effect of EXBF could be explained by its impact on early life growth development, e.g. ages at adiposity peak (AP) and adiposity rebound (AR) and BMI velocities in the first years of life, which are major determinants of overweight and obesity later in life...
October 1, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29039470/effects-of-baicalein-on-proliferation-apoptosis-migration-and-invasion-of-ewing-s-sarcoma-cells
#20
Conglin Ye, Xiaolong Yu, Jin Zeng, Min Dai, Bin Zhang
Ewing's sarcoma (ES) is a rare tumor that is more frequent in pediatric and adolescent age groups. In the past few decades, long-term survival in affected patients has improved due to the success of multimodal therapy. However, long-term survival is inevitably restricted by the late side-effects of chemotherapy. Besides, early metastasis also contributes to the poor prognosis of ES. Recently, traditional Chinese medicines (TCMs) have increasingly attracted interest due to the promising clinical results and fewer side-effects for the treatment of cancers...
October 10, 2017: International Journal of Oncology
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