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https://www.readbyqxmd.com/read/28499112/polygenic-risk-personality-dimensions-and-adolescent-alcohol-use-problems-a-longitudinal-study
#1
James J Li, Jeanne E Savage, Kenneth S Kendler, Matthew Hickman, Liam Mahedy, John Macleod, Jaakko Kaprio, Richard J Rose, Danielle M Dick
OBJECTIVE: Alcohol use problems are common during adolescence and can predict serious negative outcomes in adulthood, including substance dependence and psychopathology. The current study examines the notion that alcohol use problems are driven by polygenic influences and that genetic influences may indirectly affect alcohol use problems through multiple pathways of risk, including variations in personality. METHOD: We used a genome-wide approach to examine associations between genetic risk for alcohol use problems, personality dimensions, and adolescent alcohol use problems in two separate longitudinal population-based samples, the Finnish Twin Cohort (FinnTwin12) and the Avon Longitudinal Study of Parents and Children (ALSPAC)...
May 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28453778/exploring-a-causal-role-of-dna-methylation-in-the-relationship-between-maternal-vitamin-b12-during-pregnancy-and-child-s-iq-at-age-8-cognitive-performance-and-educational-attainment-a-two-step-mendelian-randomization-study
#2
Doretta Caramaschi, Gemma C Sharp, Ellen A Nohr, Katie Berryman, Sarah J Lewis, George Davey Smith, Caroline L Relton
An adequate intake of vitamin B12 during pregnancy plays an important role in offspring neurodevelopment, potentially via epigenetic processes. We used a two-step Mendelian randomization approach to assess whether DNA methylation plays a mediating and causal role in associations between maternal vitamin B12 status and offspring's cognition. Firstly, we estimated the causal effect of maternal vitamin B12 levels on cord blood DNA methylation using the maternal FUT2 genotypes rs492602:A>G and rs1047781:A>T as proxies for circulating vitamin B12 levels in the Avon Longitudinal Study of Parents and Children (ALSPAC) and we tested the observed associations in a replication cohort...
April 27, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28448061/grand-maternal-smoking-in-pregnancy-and-grandchild-s-autistic-traits-and-diagnosed-autism
#3
Jean Golding, Genette Ellis, Steven Gregory, Karen Birmingham, Yasmin Iles-Caven, Dheeraj Rai, Marcus Pembrey
Although there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother's (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446887/the-impact-of-prenatal-parental-locus-of-control-on-children-s-psychological-outcomes-in-infancy-and-early-childhood-a-prospective-5-year-study
#4
Stephen Nowicki, Yasmin Iles-Caven, Steven Gregory, Genette Ellis, Jean Golding
Locus of control is one of the most widely studied concepts in the history of personality psychology. In spite of its popularity and its associations with numerous relevant outcomes, the ability of locus of control to predict future behaviors involving parenting effectiveness has been under researched. The few parent locus of control children's outcome studies are characterized by cross-sectional methodologies that focus on mothers. The present study uses a prospective methodology to compare data on mothers' and fathers' locus of control with their child's behavior outcomes from a large scale research project, the Avon Longitudinal Study of Parents and Children (ALSPAC)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28444145/parental-separation-and-cardiometabolic-risk-factors-in-late-adolescence-a-cross-cohort-comparison
#5
Ana Luiza Gonçalves Soares, Helen Gonçalves, Alicia Matijasevich, Maija Sequeira, George Davey Smith, Ana M B Menezes, Maria Cecília Assunção, Fernando C Wehrmeister, Abigail Fraser, Laura D Howe
The aim of this study was to explore the association between parental separation during childhood (up to 18 years of age) and cardiometabolic risk factors (body mass index, fat mass index, blood pressure, physical activity, smoking, and alcohol consumption) in late adolescence using a cross-cohort comparison and to explore whether associations differ according to the age at which the parental separation occurred and the presence or absence of parental conflict prior to separation. Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) (1991-2011) and the 1993 Pelotas Birth Cohort (Brazil) (1993-2011) were used...
May 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28441402/sex-discordance-in-asthma-and-wheeze-prevalence-in-two-longitudinal-cohorts
#6
Ryan Arathimos, Raquel Granell, John Henderson, Caroline L Relton, Kate Tilling
Sex discordance in asthma prevalence has been previously reported, with higher prevalence in males before puberty, and in females after puberty; the adolescent "switch". However, cross-sectional studies have suggested a narrowing of this discordance in recent decades. We used a combination of cross-sectional and longitudinal modelling to examine sex differences in asthma, wheeze and longitudinal wheezing phenotypes in two UK birth cohorts, the Avon Longitudinal Study of Parents and Children (ALSPAC; born 1991-92 with data from age 0-18 years) and the Millennium Cohort Study (MCS; born 2000-02 with data from age 3-10 years)...
2017: PloS One
https://www.readbyqxmd.com/read/28439312/validation-of-the-multiplier-method-for-leg-length-predictions-on-a-large-european-cohort-and-an-assessment-of-the-effect-of-physiological-age-on-predictions
#7
J J Aird, C L Cheesman, A T Schade, F P Monsell
PURPOSE: The Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort was used to determine the accuracy of the Paley multiplier method for predicting leg length. Using menarche as a proxy, physiological age was then used to increase the accuracy of the multiplier. METHODS: Chronological age was corrected in female patients over the age of eight years with documented date of first menses. Final sub-ischial leg length and predicted final leg length were predicted for all data points...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28411449/prenatal-concentrations-of-perfluoroalkyl-substances-and-early-communication-development-in-british-girls
#8
Zuha Jeddy, Terryl J Hartman, Ethel V Taylor, Cayla Poteete, Katarzyna Kordas
Perfluoroalkyl substances (PFAS), found in many household products and classed as endocrine disrupting chemicals, can be transferred through the placenta and are associated with multiple developmental deficits in offspring. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the association between intrauterine exposure to PFAS and early communication development in 432 mother-daughter dyads at 15 and 38months of age. Concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) were measured in maternal serum collected during pregnancy...
April 12, 2017: Early Human Development
https://www.readbyqxmd.com/read/28392908/shared-genetic-influences-between-dimensional-asd-and-adhd-symptoms-during-child-and-adolescent-development
#9
Evie Stergiakouli, George Davey Smith, Joanna Martin, David H Skuse, Wolfgang Viechtbauer, Susan M Ring, Angelica Ronald, David E Evans, Simon E Fisher, Anita Thapar, Beate St Pourcain
BACKGROUND: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28349888/screening-for-familial-hypercholesterolaemia-in-childhood-avon-longitudinal-study-of-parents-and-children-alspac
#10
Marta Futema, Jackie A Cooper, Marietta Charakida, Christopher Boustred, Naveed Sattar, John Deanfield, Debbie A Lawlor, Nicholas J Timpson, Steve E Humphries, Aroon D Hingorani
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) is an autosomal-dominant disease with frequency of 1/500 to 1/250 that leads to premature coronary heart disease. New approaches to identify FH mutation-carriers early are needed to prevent premature cardiac deaths. In a cross-sectional study of the Avon Longitudinal Study of Parents and Children (ALSPAC), we evaluated the biochemical thresholds for FH screening in childhood, and modelled a two-stage biochemical and sequencing screening strategy for FH detection...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28338919/genetic-overlap-between-schizophrenia-and-developmental-psychopathology-longitudinal-and-multivariate-polygenic-risk-prediction-of-common-psychiatric-traits-during-development
#11
Michel G Nivard, Suzanne H Gage, Jouke J Hottenga, Catharina E M van Beijsterveldt, Abdel Abdellaoui, Meike Bartels, Bart M L Baselmans, Lannie Ligthart, Beate St Pourcain, Dorret I Boomsma, Marcus R Munafò, Christel M Middeldorp
BACKGROUND: Several nonpsychotic psychiatric disorders in childhood and adolescence can precede the onset of schizophrenia, but the etiology of this relationship remains unclear. We investigated to what extent the association between schizophrenia and psychiatric disorders in childhood is explained by correlated genetic risk factors. METHODS: Polygenic risk scores (PRS), reflecting an individual's genetic risk for schizophrenia, were constructed for 2588 children from the Netherlands Twin Register (NTR) and 6127 from the Avon Longitudinal Study of Parents And Children (ALSPAC)...
March 11, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28335879/are-social-and-communication-difficulties-a-risk-factor-for-the-development-of-social-anxiety
#12
Hannah Pickard, Fruhling Rijsdijk, Francesca Happé, William Mandy
OBJECTIVE: Social anxiety (SA) is a common condition associated with social and communication (SC) difficulties in typically developing young people, as well as those with autism spectrum disorder (ASD). Whether SC difficulties place children at risk for developing SA is unclear. Using a longitudinal design, the present study aimed to disentangle the relationship between SA symptoms and SC difficulties using a population-based sample of 9,491 children from the Avon Longitudinal Study of Parents and Children (ALSPAC)...
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28334631/internalizing-and-externalizing-disorders-in-childhood-and-adolescence-a-latent-transition-analysis-using-alspac-data
#13
Eoin McElroy, Mark Shevlin, Jamie Murphy
BACKGROUND: Research examining the association between internalizing and externalizing dimensions of psychopathology has relied heavily on variable-centered analytical techniques. Person-centered methodologies complement the variable-centered approach, and may help explain the medium-to-large correlations that exist between higher order dimensions of psychopathology. What little person-centered research exists has been cross-sectional and utilized adult samples. The present study sought to take a person-centered approach to the modeling of psychiatric comorbidity during a key developmental phase; middle childhood through adolescence...
May 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28314984/substance-use-criminal-behaviour-and-psychiatric-symptoms-following-childhood-traumatic-brain-injury-findings-from-the-alspac-cohort
#14
Eleanor Kennedy, Jon Heron, Marcus Munafò
Recent research suggests a link between traumatic brain injury (TBI) in youth and later risk behaviour. We explored the association between mild TBI and psychiatric symptoms, substance use and criminal behaviour using data from a longitudinal birth cohort. Participants with mild TBI (n = 800), orthopaedic injuries (n = 2305) and no injuries (n = 8307) were identified from self and parent reports up to age 16 years. Self-report measures of substance use (alcohol, tobacco and cannabis) and criminal behaviours, and parent-reported psychiatric symptoms were collected at age 17 years...
March 17, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28251825/maternal-dietary-patterns-during-pregnancy-and-intelligence-quotients-in-the-offspring-at-8%C3%A2-years-of-age-findings-from-the-alspac-cohort
#15
Ana Amélia Freitas-Vilela, Rebecca M Pearson, Pauline Emmett, Jon Heron, Andrew D A C Smith, Alan Emond, Joseph R Hibbeln, Maria Beatriz Trindade Castro, Gilberto Kac
Dietary intake during pregnancy may influence child neurodevelopment and cognitive function. This study aims to investigate the associations between dietary patterns obtained in pregnancy and intelligence quotients (IQ) among offspring at 8 years of age. Pregnant women enrolled in the Avon Longitudinal Study of Parents and Children completed a food frequency questionnaire at 32 weeks' gestation (n = 12,195). Dietary patterns were obtained by cluster analysis. Three clusters best described women's diets during pregnancy: "fruit and vegetables," "meat and potatoes," and "white bread and coffee...
March 2, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28246294/the-role-of-dna-methylation-in-type-2-diabetes-aetiology-using-genotype-as-a-causal-anchor
#16
Hannah R Elliott, Hashem A Shihab, Gabrielle A Lockett, John W Holloway, Allan F McRae, George Davey Smith, Susan M Ring, Tom R Gaunt, Caroline L Relton
Several studies have investigated the relationship between genetic variation and DNA methylation with respect to type 2 diabetes but it is unknown if DNA methylation is a mediator in the disease pathway or if it is altered in response to disease state. This study uses genotypic information as a causal anchor to help decipher the likely role of DNA methylation measured in peripheral blood in the aetiology of type 2 diabetes.Illumina HumanMethylation450 BeadChip data was generated on 1,018 young individuals from the ALSPAC cohort...
February 28, 2017: Diabetes
https://www.readbyqxmd.com/read/28245296/time-outdoors-at-specific-ages-during-early-childhood-and-the-risk-of-incident-myopia
#17
Rupal L Shah, Yu Huang, Jeremy A Guggenheim, Cathy Williams
Purpose: Time outdoors during childhood is negatively associated with incident myopia. Consequently, additional time outdoors has been suggested as a public health intervention to reduce the prevalence of myopia. We investigated whether there were specific ages during early childhood when the time outdoors versus incident myopia association was strongest. Methods: Children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) were studied from age 2 to 15 years...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28222824/curiosity-killed-the-cat-no-evidence-of-an-association-between-cat-ownership-and-psychotic-symptoms-at-ages-13-and-18-years-in-a-uk-general-population-cohort
#18
F Solmi, J F Hayes, G Lewis, J B Kirkbride
BACKGROUND: Congenital or early life infection with Toxoplasma gondii has been implicated in schizophrenia aetiology. Childhood cat ownership has been hypothesized as an intermediary marker of T. gondii infection and, by proxy, as a risk factor for later psychosis. Evidence supporting this hypothesis is, however, limited. METHOD: We used birth cohort data from the Avon Longitudinal Study of Parents and Children (ALSPAC) to investigate whether cat ownership in pregnancy and childhood (ages 4 and 10 years) was associated with psychotic experiences (PEs) in early (age 13, N = 6705) and late (age 18, N = 4676) adolescence, rated from semi-structured interviews...
February 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28203641/the-antecedents-of-women-s-external-locus-of-control-associations-with-characteristics-of-their-parents-and-their-early-childhood
#19
Jean Golding, Steven Gregory, Yasmin Iles-Caven, Stephen Nowicki
Locus of control (LOC) measures individuals' expectancies regarding their ability to affect what happens to them based on how they behave. The more they believe their behaviour has something to do with what happens to them the more internal they are. In contrast the more they perceive that what happens to them is beyond their control and determined by luck, fate, chance or powerful others the more external they are. Copious research findings suggest that external LOC (ELOC) is associated with many adverse personal, social, academic and health outcomes...
January 2017: Heliyon
https://www.readbyqxmd.com/read/28118352/using-genetic-variation-to-explore-the-causal-effect-of-maternal-pregnancy-adiposity-on-future-offspring-adiposity-a-mendelian-randomisation-study
#20
Rebecca C Richmond, Nicholas J Timpson, Janine F Felix, Tom Palmer, Romy Gaillard, George McMahon, George Davey Smith, Vincent W Jaddoe, Debbie A Lawlor
BACKGROUND: It has been suggested that greater maternal adiposity during pregnancy affects lifelong risk of offspring fatness via intrauterine mechanisms. Our aim was to use Mendelian randomisation (MR) to investigate the causal effect of intrauterine exposure to greater maternal body mass index (BMI) on offspring BMI and fat mass from childhood to early adulthood. METHODS AND FINDINGS: We used maternal genetic variants as instrumental variables (IVs) to test the causal effect of maternal BMI in pregnancy on offspring fatness (BMI and dual-energy X-ray absorptiometry [DXA] determined fat mass index [FMI]) in a MR approach...
January 2017: PLoS Medicine
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