keyword
MENU ▼
Read by QxMD icon Read
search

ALSPAC

keyword
https://www.readbyqxmd.com/read/29773208/childhood-sleep-and-adolescent-chronic-fatigue-syndrome-cfs-me-evidence-of-associations-in-a-uk-birth-cohort
#1
Simon M Collin, Tom Norris, Paul Gringras, Peter S Blair, Kate Tilling, Esther Crawley
OBJECTIVE/BACKGROUND: Sleep abnormalities are characteristic of chronic fatigue syndrome (CFS, also known as 'ME'), however it is unknown whether sleep might be a causal risk factor for CFS/ME. PATIENTS/METHODS: We analysed data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. We describe sleep patterns of children aged 6 months to 11 years, who were subsequently classified as having (or not having) 'chronic disabling fatigue' (CDF, a proxy for CFS/ME) between the ages 13 and 18 years, and we investigated the associations of sleep duration at age nine years with CDF at age 13 years, as well as sleep duration at age 11 years with CDF at age 16 years...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29757392/thyroid-function-in-early-pregnancy-child-iq-and-autistic-traits-a-meta-analysis-of-individual-participant-data
#2
Deborah Levie, Tim I M Korevaar, Sarah C Bath, Albert Dalmau-Bueno, Mario Murcia, Mercedes Espada, Mariana Dineva, Jesús M Ibarluzea, Jordi Sunyer, Henning Tiemeier, Marisa Rebagliato, Margaret P Rayman, Robin P Peeters, Mònica Guxens
Context: Low maternal free thyroxine (FT4) has been associated with poor child neurodevelopment in some single-centre studies. Evidence remains scarce for potential adverse effects of high FT4 and whether associations differ in countries with a different iodine status. Objective: To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Design, Setting and Participants: Meta-analysis of individual-participant data compromising 9,036 mother-child pairs from three prospective population-based birth cohorts: INMA (Spain), Generation R (The Netherlands) and ALSPAC (United Kingdom)...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29750675/maternal-pre-pregnancy-weight-status-and-adolescent-eating-disorder-behaviors-a-longitudinal-study-of-risk-pathways
#3
Nadia Micali, Rhian M Daniel, George B Ploubidis, Bianca L De Stavola
BACKGROUND: Maternal characteristics and childhood growth have been identified as risk factors for eating disorders. Most studies to date have been unable to investigate these factors prospectively while accounting for their interdependencies. We address this by investigating whether the association of maternal pre-pregnancy body mass index (ppBMI) with adolescent eating disorder behaviors can be explained by childhood growth and/or a concurrent environmental pathway captured by maternal eating habits...
May 10, 2018: Epidemiology
https://www.readbyqxmd.com/read/29748737/psychosocial-risks-for-constipation-and-soiling-in-primary-school-children
#4
Carol Joinson, Mariusz T Grzeda, Alexander von Gontard, Jon Heron
To examine prospective associations between psychosocial problems and childhood constipation and soiling. We used latent classes of constipation and soiling ('constipation alone', 'soiling alone', 'constipation with soiling') extracted from longitudinal maternally reported data on constipation (4-10 years) and soiling (4-9 years) from 8435 children (4353 males, 4082 females) from the ALSPAC cohort. We examined the association between maternally reported psychosocial problems at 2-3 years (difficult temperament, behaviour/emotional problems, temper tantrums, behavioural sleep problems and stressful events) and the latent classes using multinomial logistic regression adjusted for a range of confounders relating to the child and family (reference category = normative latent class with very low probability of constipation/soiling)...
May 10, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29725146/events-associated-with-stability-and-change-in-adult-locus-of-control-orientation-over-a-six-year-period
#5
Stephen Nowicki, Genette Ellis, Yasmin Iles-Caven, Steven Gregory, Jean Golding
Although locus of control (LOC) has been the focus of thousands of studies we know little about how or if it changes over time and what is associated with change. Our lack of knowledge stems in part from the past use of cross-sectional and not longitudinal methodologies to study small numbers of participants from non-representative populations. The purpose of the present study was to use a longitudinal design with a large representative population to provide relevant information concerning the stability and change of adult LOC...
May 1, 2018: Personality and Individual Differences
https://www.readbyqxmd.com/read/29723752/prenatal-lead-cadmium-and-mercury-exposure-and-associations-with-motor-skills-at-age-7-years-in-a-uk-observational-birth-cohort
#6
Caroline M Taylor, Alan M Emond, Raghu Lingam, Jean Golding
BACKGROUND: Lead and mercury are freely transferred across the placenta, while cadmium tends to accumulate in the placenta. Each contributes to adverse neurological outcomes for the child. Although prenatal heavy metal exposure has been linked with an array of neurodevelopmental outcomes in childhood, its association with the development of motor skills in children has not been robustly studied. AIMS/OBJECTIVE: The aim of the present study was to investigate the association between prenatal exposure to lead, cadmium and mercury, measured as maternal blood concentrations during pregnancy, and motor skills, measured as subtests of the Movement Assessment Battery for Children (Movement ABC) at age 7 years in a large sample of mother-child pairs enrolled in a UK observational birth cohort study (Avon Longitudinal Study of Parents and Children, ALSPAC)...
April 30, 2018: Environment International
https://www.readbyqxmd.com/read/29718110/tracking-the-epigenetic-clock-across-the-human-life-course-a-meta-analysis-of-longitudinal-cohort-data
#7
Riccardo E Marioni, Matthew Suderman, Brian H Chen, Steve Horvath, Stefania Bandinelli, Tiffany Morris, Stephan Beck, Luigi Ferrucci, Nancy L Pedersen, Caroline L Relton, Ian J Deary, Sara Hägg
Background: Epigenetic clocks based on DNA methylation yield high correlations with chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not known how Δage (epigenetic age - chronological age) changes over time or if it remains constant from childhood to old age. Here, we investigate this using longitudinal DNA methylation data from five datasets, covering most of the human life course. Methods: Two measures of the epigenetic clock (Hannum and Horvath) are used to calculate Δage in the following cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC) offspring (n = 986, total age-range 7-19 years, 2 waves), ALSPAC mothers (n = 982, 16-60 years, 2 waves), InCHIANTI (n = 460, 21-100 years, 2 waves), SATSA (n = 373, 48-99 years, 5 waves), Lothian Birth Cohort 1936 (n = 1,054, 70-76 years, 3 waves), and Lothian Birth Cohort 1921 (n = 476, 79-90 years, 3 waves)...
March 20, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29713443/prenatal-mercury-exposure-and-features-of-autism-a-prospective-population-study
#8
Jean Golding, Dheeraj Rai, Steven Gregory, Genette Ellis, Alan Emond, Yasmin Iles-Caven, Joseph Hibbeln, Caroline Taylor
Background: Mercury (Hg) has been suspected of causing autism in the past, especially a suspected link with vaccinations containing thiomersal, but a review of the literature shows that has been largely repudiated. Of more significant burden is the total quantity of Hg in the environment. Here, we have used the Avon Longitudinal Study of Parents and Children (ALSPAC) to test whether prenatal exposure from total maternal blood Hg in the first half of pregnancy is associated with the risk of autism or of extreme levels of autistic traits...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29687944/association-of-copy-number-variation-across-the-genome-with-neuropsychiatric-traits-in-the-general-population
#9
Anna L Guyatt, Evie Stergiakouli, Joanna Martin, James Walters, Michael O'Donovan, Michael Owen, Anita Thapar, George Kirov, Santiago Rodriguez, Dheeraj Rai, Stan Zammit, Tom R Gaunt
Copy number variants (CNVs) are associated with psychiatric conditions in clinical populations. The relationship between rare CNV burden and neuropsychiatric traits in young, general populations is underexplored. A total of 6,807 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were studied. CNVs were inferred from single nucleotide polymorphism-array data using PennCNV. After excluding children with known candidate CNVs for schizophrenia (SCZ), rare (<1%) CNV burden (total number of genes affected by CNVs, total length of CNVs, and largest CNV carried) was analyzed in relation to: psychotic experiences (PEs) and anxiety/depression in adolescence; autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), ASD and ADHD traits, and cognitive measures during childhood...
April 24, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29683192/investigating-late-onset-adhd-a-population-cohort-investigation
#10
Miriam Cooper, Gemma Hammerton, Stephan Collishaw, Kate Langley, Ajay Thapar, Søren Dalsgaard, Evie Stergiakouli, Kate Tilling, George Davey Smith, Barbara Maughan, Michael O'Donovan, Anita Thapar, Lucy Riglin
BACKGROUND: Adult ADHD has been assumed to be a continuation of childhood-onset ADHD. However, recent studies have identified individuals with ADHD in adulthood who have not had ADHD in childhood. Whether or not these individuals have a 'typical' neurodevelopmental profile is not clear. METHODS: We tested two explanations for the emergence of apparent late-onset ADHD symptomatology using the ALSPAC epidemiological cohort, by grouping individuals according to their scores on the Strengths and Difficulties Questionnaire (SDQ) hyperactivity subscale at ages 12 and 17 years...
April 23, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29672866/the-development-of-autistic-social-traits-across-childhood-and-adolescence-in-males-and-females
#11
William Mandy, Liz Pellicano, Beate St Pourcain, David Skuse, Jon Heron
BACKGROUND: Autism is a dimensional condition, representing the extreme end of a continuum of social competence that extends throughout the general population. Currently, little is known about how autistic social traits (ASTs), measured across the full spectrum of severity, develop during childhood and adolescence, including whether there are developmental differences between boys and girls. Therefore, we sought to chart the trajectories of ASTs in the general population across childhood and adolescence, with a focus on gender differences...
April 19, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29665469/total-mercury-exposure-in-early-pregnancy-has-no-adverse-association-with-scholastic-ability-of-the-offspring-particularly-if-the-mother-eats-fish
#12
Joseph Hibbeln, Steven Gregory, Yasmin Iles-Caven, Caroline M Taylor, Alan Emond, Jean Golding
There is a public perception that relatively low doses of mercury found in seafood are harmful to the fetal brain but little consistent evidence to support this. In earlier publications we have shown no adverse associations between maternal total blood mercury levels and child behaviour, early development or cognitive function as measured by IQ. However, for IQ the lack of adverse association was conditional upon the mother being a fish eater. In this paper we analyse further data from the Avon Longitudinal Study of Parents and Children (ALSPAC), this time examining whether prenatal exposure to total mercury is associated with the child's scholastic abilities in reading, spelling, phoneme awareness, mathematics and science; the number of participants with prenatal mercury and relevant test results varied from 1500 to 2200...
April 14, 2018: Environment International
https://www.readbyqxmd.com/read/29649967/influence-of-maternal-and-own-genotype-at-tanning-dependence-related-snps-on-sun-exposure-in-childhood
#13
Jasmine Khouja, Sarah J Lewis, Carolina Bonilla
BACKGROUND: Research suggests there may be a genetic influence on the likelihood of becoming tanning dependent (TD). The way in which mothers regulate their children's sun exposure may be affected by being TD. We investigated the associations between single nucleotide polymorphisms (SNPs) related to being TD and early sun exposure. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used. Associations between 17 TD related SNPs in children and their mothers and 10 sun exposure variables in children (assessed via questionnaire at age 8) were analyzed in logistic and ordinal logistic regressions...
April 12, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29628377/lung-function-trajectories-from-pre-school-age-to-adulthood-and-their-associations-with-early-life-factors-a-retrospective-analysis-of-three-population-based-birth-cohort-studies
#14
Danielle C M Belgrave, Raquel Granell, Steve W Turner, John A Curtin, Iain E Buchan, Peter N Le Souëf, Angela Simpson, A John Henderson, Adnan Custovic
BACKGROUND: Maximal lung function in early adulthood is an important determinant of mortality and COPD. We investigated whether distinct trajectories of lung function are present during childhood and whether these extend to adulthood and infancy. METHODS: To ascertain trajectories of FEV1 , we studied two population-based birth cohorts (MAAS and ALSPAC) with repeat spirometry from childhood into early adulthood (1046 participants from 5-16 years and 1390 participants from 8-24 years)...
April 5, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29597345/dna-methylome-marks-of-exposure-to-particulate-matter-at-three-time-points-in-early-life
#15
Michelle Plusquin, Marc Chadeau-Hyam, Akram Ghantous, Rossella Alfano, Mariona Bustamante, Leda Chatzi, Cyrille Cuenin, John Gulliver, Zdenko Herceg, Manolis Kogevinas, Tim Nawrot, Costanza Pizzi, Daniela Porta, Caroline Relton, Lorenzo Richiardi, Oliver Robinson, Jordi Sunyer, Roel Vermeulen, Annette Vriens, Martine Vrijheid, John Henderson, Paolo Vineis
Maternal exposure to airborne particulate matter (PM) has been associated with restricted foetal growth and reduced birthweight. Here, we performed methylome-wide analyses of cord and children's blood DNA in relation to residential exposure to PM smaller than 10µm (PM10). This study included participants of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC, cord blood, n=780; blood at age 7, n=757 and age 15-17, n=850) and the EXPOsOMICS birth cohort consortium including cord blood from ENVIRONAGE (n=197), INMA (n=84), Piccolipiù (n=99) and Rhea (n=75)...
March 30, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29556667/adverse-life-outcomes-associated-with-adolescent-psychotic-experiences-and-depressive-symptoms
#16
Jonathan Davies, Sarah Sullivan, Stanley Zammit
PURPOSE: To investigate whether psychotic experiences and depressive symptoms at ages 12 and 18 years are associated with adverse life outcomes across a range of functional domains between 16 and 20 years of age. METHODS: Data were gathered from ALSPAC, a UK birth cohort. Individuals were assessed with the semi-structured Psychosis-Like Symptoms Interview and the Short Mood and Feeling Questionnaire at ages 12 and 18 years. Logistic regression was used to explore associations with outcomes in education, occupation, social functioning, substance use (alcohol, cannabis, smoking, and other drugs), and illegal behaviour between the ages of 16 and 20 years...
March 19, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29520540/co-occurring-internalizing-and-externalizing-psychopathology-in-childhood-and-adolescence-a-network-approach
#17
Eoin McElroy, Mark Shevlin, Jamie Murphy, Orla McBride
The network approach suggests that psychopathology arises from complex associations between symptoms and may offer insight into the mechanisms that underpin psychiatric comorbidities. The transition from childhood to adolescence is a key period in the development of psychopathology, yet has rarely been considered from a network perspective. As such, the present study examined the network structure of internalizing and externalizing psychopathology from middle childhood through adolescence using data from the Avon Longitudinal Study of Parents and Children (ALSPAC; n = 4405)...
March 8, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29509885/is-smoking-heaviness-causally-associated-with-alcohol-use-a-mendelian-randomization-study-in-four-european-cohorts
#18
Michelle Taylor, Line Rode, Johan Bjørngaard, Amy E Taylor, Stig E Bojesen, Bjørn O Åsvold, Maiken E Gabrielsen, Glyn Lewis, Børge G Nordestgaard, Pål R Romundstad, Matthew Hickman, Marcus R Munafò
Background: Observational studies have shown that tobacco and alcohol use co-occur, but it is not clear whether this relationship is causal. Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK Biobank, we used observational methods to test the hypothesis that smoking heaviness increases alcohol consumption. Mendelian randomization (MR) analyses were then used to test the causal relationship between smoking heaviness and alcohol consumption using 55 967 smokers from four European studies [ALSPAC, The Nord-Trøndelag Health Study (HUNT), the Copenhagen General Population Study (CGPS) and UK Biobank]...
March 2, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29494520/iodine-status-during-pregnancy-in-a-region-of-mild-to-moderate-iodine-deficiency-is-not-associated-with-adverse-obstetric-outcomes-results-from-the-avon-longitudinal-study-of-parents-and-children-alspac
#19
Barbara Torlinska, Sarah C Bath, Aisha Janjua, Kristien Boelaert, Shiao-Yng Chan
Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild-to-moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss...
March 1, 2018: Nutrients
https://www.readbyqxmd.com/read/29492978/what-distinguishes-adolescents-with-suicidal-thoughts-from-those-who-have-attempted-suicide-a-population-based-birth-cohort-study
#20
Becky Mars, Jon Heron, E David Klonsky, Paul Moran, Rory C O'Connor, Kate Tilling, Paul Wilkinson, David Gunnell
BACKGROUND: Only one-third of young people who experience suicidal ideation attempt suicide. It is important to identify factors which differentiate those who attempt suicide from those who experience suicidal ideation but do not act on these thoughts. METHODS: Participants were 4,772 members of the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK population-based birth cohort. Suicide ideation and attempts were assessed at age 16 years via self-report questionnaire...
March 1, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
keyword
keyword
20283
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"