keyword
MENU ▼
Read by QxMD icon Read
search

ALSPAC

keyword
https://www.readbyqxmd.com/read/29135081/adverse-childhood-experiences-aces-and-adiposity-in-adolescents-a-cross-cohort-comparison
#1
Ana Luiza G Soares, Alicia Matijasevich, Ana M B Menezes, Maria Cecília Assunção, Fernando C Wehrmeister, Laura D Howe, Helen Gonçalves
OBJECTIVE: This study aimed to assess the association between adverse childhood experiences (ACEs) and adiposity in adolescents from two cohorts in different socioeconomic contexts. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) and the 1993 Pelotas Cohort (Brazil) were used. Six ACEs were assessed in both cohorts up to age 15. At 15 years, body mass index (BMI) and waist circumference (WC) were measured, and at 18 years, BMI, fat mass index, and android fat percentage were assessed...
November 14, 2017: Obesity
https://www.readbyqxmd.com/read/29129583/identification-of-atopic-dermatitis-subgroups-in-children-from-two-longitudinal-birth-cohorts
#2
Lavinia Paternoster, Olga E M Savenije, Jon Heron, David M Evans, Judith M Vonk, Bert Brunekreef, Alet H Wijga, A John Henderson, Gerard H Koppelman, Sara J Brown
BACKGROUND: Atopic dermatitis (AD) is a prevalent disease with variable natural history. Longitudinal birth cohort studies provide an opportunity to define subgroups based on disease trajectories, which may represent different genetic and environmental pathomechanisms. OBJECTIVE: To investigate the existence of distinct longitudinal phenotypes of AD and test whether these findings are reproducible in two independent cohorts. METHODS: The presence of AD was examined in two birth cohort studies including 9,894 children from the UK (ALSPAC) and 3,652 from the Netherlands (PIAMA)...
November 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29124294/the-relationship-between-financial-difficulty-and-childhood-symptoms-of-attention-deficit-hyperactivity-disorder-a-uk-longitudinal-cohort-study
#3
Abigail Emma Russell, Tamsin Ford, Ginny Russell
PURPOSE: Attention deficit/hyperactivity disorder (ADHD) is associated with socioeconomic status (SES), in that children who grow up in low SES families are at an increased risk of ADHD symptoms and diagnosis. The current study explores whether different levels of ADHD symptoms are associated with prior changes in the SES facet of financial difficulty. METHODS: Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined symptoms of ADHD measured by the Strengths and Difficulties Questionnaire (SDQ) hyperactivity subscale in relation to parent-reported changes in financial difficulty, grouped into four repeated measures at four time points across childhood; (n = 6416)...
November 9, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29122994/childhood-psychosocial-adversity-and-female-reproductive-timing-a-cohort-study-of-the-alspac-mothers
#4
Maria C Magnus, Emma L Anderson, Laura D Howe, Carol J Joinson, Ian S Penton-Voak, Abigail Fraser
BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children...
November 9, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29106580/physical-activity-phenotyping-with-activity-bigrams-and-their-association-with-bmi
#5
Louise A C Millard, Kate Tilling, Debbie A Lawlor, Peter A Flach, Tom R Gaunt
Background: Analysis of physical activity usually focuses on a small number of summary statistics derived from accelerometer recordings: average counts per minute and the proportion of time spent in moderate-vigorous physical activity or in sedentary behaviour. We show how bigrams, a concept from the field of text mining, can be used to describe how a person's activity levels change across (brief) time points. These variables can, for instance, differentiate between two people spending the same time in moderate activity, where one person often stays in moderate activity from one moment to the next and the other does not...
June 29, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29098496/partitioning-phenotypic-variance-due-to-parent-of-origin-effects-using-genomic-relatedness-matrices
#6
Charles Laurin, Gabriel Cuellar-Partida, Gibran Hemani, George Davey Smith, Jian Yang, David M Evans
We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals' phased genotypes. Genome-wide SNP data from parent child duos or trios is required to obtain relatedness matrices indexing the parental origin of offspring alleles, as well as offspring phenotype data to partition the trait variation into variance components...
November 2, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29080482/the-impact-of-developmental-coordination-disorder-on-educational-achievement-in-secondary-school
#7
Ian Harrowell, Linda Hollén, Raghu Lingam, Alan Emond
BACKGROUND: Developmental coordination disorder (DCD) is a common developmental disorder but its long term impact on health and education are poorly understood. AIM: To assess the impact of DCD diagnosed at 7 years, and co-occurring developmental difficulties, on educational achievement at 16 years. METHODS: A prospective cohort study using data from the Avon Longitudinal Study of Parents and Children (ALSPAC). National General Certificate of Secondary Education (GCSE) exam results and Special Educational Needs provision were compared for adolescents with DCD (n=284) and controls (n=5425)...
October 25, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29074331/intra-individual-variability-and-psychotic-like-experiences-in-adolescents-findings-from-the-alspac-cohort
#8
Simon Wallace, Richard J Linscott
Clinical and epidemiological studies have demonstrated associations between elevated intra-individual variability (IIV) of reaction time and psychotic disorders. However, little attention has been paid to the relationship between performance stability and psychotic-like experiences (PLE) in adolescence, before psychotic disorder onset. Data from 6702 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to address this issue. Children took part in a semi-structured clinical interview regarding psychotic symptoms at age 12 and 18, and reaction time variability was assessed at age 13 and 15...
October 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29046734/epigenome-wide-association-study-of-asthma-and-wheeze-in-childhood-and-adolescence
#9
Ryan Arathimos, Matthew Suderman, Gemma C Sharp, Kimberley Burrows, Raquel Granell, Kate Tilling, Tom R Gaunt, John Henderson, Susan Ring, Rebecca C Richmond, Caroline L Relton
BACKGROUND: Asthma heritability has only been partially explained by genetic variants and is known to be sensitive to environmental factors, implicating epigenetic modifications such as DNA methylation in its pathogenesis. METHODS: Using data collected in the Avon Longitudinal Study of Parents and Children (ALSPAC), we assessed associations of asthma and wheeze with DNA methylation at 7.5 and 16.5 years, at over 450,000 CpG sites in DNA from the peripheral blood of approx...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29040503/the-role-of-early-life-growth-development-the-fto-gene-and-exclusive-breastfeeding-on-child-bmi-trajectories
#10
Yan Yan Wu, Stephen Lye, Laurent Briollais
Background: Recent studies have implicated the FTO gene in child and adult obesity. A longer duration of exclusive breastfeeding (EXBF) has been shown to reduce body mass index (BMI) and the risk of being overweight in the general population and among FTO gene carriers. However, it remains unclear whether the preventive effect of EXBF could be explained by its impact on early life growth development, e.g. ages at adiposity peak (AP) and adiposity rebound (AR) and BMI velocities in the first years of life, which are major determinants of overweight and obesity later in life...
October 1, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29036721/blood-based-protein-changes-in-childhood-are-associated-with-increased-risk-for-later-psychotic-disorder-evidence-from-a-nested-case-control-study-of-the-alspac-longitudinal-birth-cohort
#11
Jane A English, Lorna M Lopez, Aoife O'Gorman, Melanie Föcking, Magdalena Hryniewiecka, Caitriona Scaife, Sophie Sabherwal, Kieran Wynne, Patrick Dicker, Bart P F Rutten, Glynn Lewis, Stanley Zammit, Mary Cannon, Gerard Cagney, David R Cotter
The identification of early biological changes associated with the psychotic disorder (PD) is important as it may provide clues to the underlying pathophysiological mechanisms. We undertook the first proteomic profiling of blood plasma samples of children who later develop a PD. Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who also participated in psychiatric assessment interviews at age 18. Protein expression levels at age 11 were compared between individuals who developed PD at age 18 (n = 37) with population-based age-matched controls (n = 38)...
July 27, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29032015/possible-positive-effect-of-the-apoe-%C3%AE%C2%B52-allele-on-cognition-in-early-to-mid-adult-life
#12
Lindsey I Sinclair, Christopher W Pleydell-Pearce, Ian N M Day
BACKGROUND: ε4 allele possession is associated with an increased risk of Alzheimer's disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life. METHODS: We invited all individuals with the rarer ε22 or ε44 genotypes and equal numbers of those with ε32, ε33 or ε34 APOE genotypes (total n invited = 1936, ages 23-67)...
October 12, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28993473/changes-in-marital-quality-over-6-years-and-its-association-with-cardiovascular-disease-risk-factors-in-men-findings-from-the-alspac-prospective-cohort-study
#13
Ian Bennett-Britton, Alison Teyhan, John Macleod, Naveed Sattar, George Davey Smith, Yoav Ben-Shlomo
BACKGROUND: Marital relationship quality has been suggested to have independent effects on cardiovascular health outcomes. This study investigates the association between changes in marital relationship quality and cardiovascular disease (CVD) risk factors in men. METHODS: We used data from The Avon Longitudinal Study of Parents and Children, a prospective birth cohort study (Bristol, UK). Our baseline sample was restricted to married study fathers with baseline relationship and covariate data (n=2496)...
November 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28989981/synthetic-alspac-longitudinal-datasets-for-the-big-data-vr-project
#14
Demetris Avraam, Rebecca C Wilson, Paul Burton
Three synthetic datasets - of observation size 15,000, 155,000 and 1,555,000 participants, respectively - were created by simulating eleven cardiac and anthropometric variables from nine collection ages of the ALSAPC birth cohort study. The synthetic datasets retain similar data properties to the ALSPAC study data they are simulated from (co-variance matrices, as well as the mean and variance values of the variables) without including the original data itself or disclosing participant information.  In this instance, the three synthetic datasets have been utilised in an academia-industry collaboration to build a prototype virtual reality data analysis software, but they could have a broader use in method and software development projects where sensitive data cannot be freely shared...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28975627/meat-consumption-during-pregnancy-and-substance-misuse-among-adolescent-offspring-stratification-of-tcn2-genetic-variants
#15
Joseph R Hibbeln, John Paul SanGiovanni, Jean Golding, Pauline M Emmett, Kate Northstone, John M Davis, Marc Schuckit, Jon Heron
BACKGROUND: Reducing meat consumption is often advised; however, inadvertent nutritional deficiencies during pregnancy may result in residual neurodevelopmental harms to offspring. This study assessed possible effects of maternal diets in pregnancy on adverse substance use among adolescent offspring. METHODS: Pregnant women and their 13-year-old offspring taking part in a prospective birth cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC), provided Food Frequency Questionnaire data from which dietary patterns were derived using principal components analysis...
November 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28974730/maternal-smoking-in-pregnancy-and-offspring-depression-a-cross-cohort-and-negative-control-study
#16
Amy E Taylor, David Carslake, Christian Loret de Mola, Mina Rydell, Tom I L Nilsen, Johan H Bjørngaard, Bernardo Lessa Horta, Rebecca Pearson, Dheeraj Rai, Maria Rosaria Galanti, Fernando C Barros, Pål R Romundstad, George Davey Smith, Marcus R Munafò
Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health study (HUNT) from Norway (N = 15,493), the Pelotas 1982 Birth Cohort Study from Brazil (N = 2,626), and the Swedish Sibling Health Cohort (N = 258 sibling pairs), we compared associations of maternal smoking during pregnancy and mother's partner's smoking during pregnancy with offspring depression and performed a discordant sibling analysis...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28957435/the-predictive-value-of-childhood-recurrent-abdominal-pain-for-adult-emotional-disorders-and-the-influence-of-negative-cognitive-style-findings-from-a-cohort-study
#17
Kate Stein, Rebecca M Pearson, Alan Stein, Mina Fazel
BACKGROUND: Recurrent abdominal pain (RAP) in childhood is common, with no explanatory pathology identified in the majority of cases. Previous studies have consistently demonstrated an association between childhood RAP and later emotional distress disorders. The aim of this study was to replicate this finding through the analysis of a large dataset, and explore how a negative style of thinking could potentially influence this relationship. METHODS: The Avon Longitudinal Study of Parents and Children (ALSPAC) is a population cohort of children born in the Avon area of the UK, between 1991-1992...
2017: PloS One
https://www.readbyqxmd.com/read/28949339/identification-of-a-plasma-signature-of-psychotic-disorder-in-children-and-adolescents-from-the-avon-longitudinal-study-of-parents-and-children-alspac-cohort
#18
A O'Gorman, T Suvitaival, L Ahonen, M Cannon, S Zammit, G Lewis, H M Roche, I Mattila, T Hyotylainen, M Oresic, L Brennan, D R Cotter
The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC)...
September 26, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28940397/haemoglobin-concentrations-in-pregnancy-and-respiratory-and-allergic-outcomes-in-childhood-birth-cohort-study
#19
Seif O Shaheen, Corrie Macdonald-Wallis, Debbie A Lawlor, A John Henderson
Background Limited epidemiological evidence suggests that low maternal iron status and anaemia in pregnancy may increase the risk of childhood respiratory and allergic outcomes. Objectives To investigate the relation between maternal haemoglobin concentrations in pregnancy and childhood respiratory and allergic outcomes. Methods In the Avon Longitudinal Study of Parents and Children (ALSPAC) we examined associations of maternal haemoglobin concentrations (g/dL) in pregnancy with hayfever, eczema, wheezing, doctor-diagnosed asthma, allergic sensitisation and total IgE at 7 years, and with lung function at 8-9 years in the offspring, after controlling for potential confounders (N=3234-5335)...
September 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28913834/which-children-and-young-people-are-excluded-from-school-findings-from-a-large-british-birth-cohort-study-the-avon-longitudinal-study-of-parents-and-children-alspac
#20
A Paget, C Parker, J Heron, S Logan, W Henley, A Emond, T Ford
BACKGROUND: Exclusion from school is increasingly recognized as pertinent to child health. National educational data reveal that boys, children who are looked-after, living in poverty, have special educational needs, or from certain ethnic minorities, are disproportionately excluded from school. As population-based data on the wider characteristics of excluded children are scarce, we aimed to describe predictors of school exclusion in the Avon Longitudinal Study of Parents and Children...
September 14, 2017: Child: Care, Health and Development
keyword
keyword
20283
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"