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A K Taylor, E Netsi, H O'Mahen, A Stein, J Evans, R M Pearson
BACKGROUND: Sleep problems are associated with increased risk of physical and mental illness. Identifying risk factors is an important method of reducing public health impact. We examined the association between maternal postnatal depression (PND) and offspring adolescent sleep problems. METHOD: The sample was derived from Avon Longitudinal Study of Parents and Children (ALSPAC) participants. A sample with complete data across all variables was used, with four outcome variables...
October 20, 2016: Psychological Medicine
M Taylor, J Sullivan, S M Ring, J Macleod, M Hickman
AIMS: We investigate the extent of and factors associated with denial of previously reported cannabis and other illicit drug use, and assess the potential of hair testing for measuring substance use in general population samples. DESIGN: Birth cohort study. SETTING: United Kingdom, 1991-present. PARTICIPANTS: 3643 participants who provided hair and self-report measures of cannabis and other illicit drug use in the Avon Longitudinal Study of Parents and Children (ALSPAC) at age 18 years...
October 15, 2016: Addiction
Steve Gregory, Yasmin Iles-Caven, Joseph R Hibbeln, Caroline M Taylor, Jean Golding
OBJECTIVES: There have been conflicting data suggesting that prenatal mercury exposure is associated with adverse cardiovascular measures in children. We therefore analysed a large prospective population study to investigate whether prenatal mercury exposure might influence offspring blood pressure (BP) and heart rate adversely. DESIGN: Prospective birth cohort. SETTING: The Avon Longitudinal Study of Parents and Children (ALSPAC). PARTICIPANTS: Maternal whole blood collected in the first half of pregnancy was assayed for mercury and selenium...
October 14, 2016: BMJ Open
Isabelle Bray, Sian Noble, Ross Robinson, Lynn Molloy, Kate Tilling
OBJECTIVE: Cohort studies must collect data from their participants as economically as possible, while maintaining response rates. This randomised controlled trial investigated whether offering a choice of online or paper questionnaires resulted in improved response rates compared with offering online first. STUDY DESIGN AND SETTING: Eligible participants were young people in the ALSPAC study (born 01/04/91-31/12/92 in the Avon area). After exclusions, 8,795 participants were randomised...
September 20, 2016: Journal of Clinical Epidemiology
Yasmin Iles-Caven, Jean Golding, Steven Gregory, Alan Emond, Caroline M Taylor
As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of early child development were collected using both hands-on expert assessment (on a random 10% sub-sample) by trained psychologists at 18 months using the Griffiths Mental Development Scales (Extended 0-8 years) and from detailed questionnaires completed by the study mothers on the whole cohort using assessments based on the Denver Developmental Screening Test. The development determined by the psychologists on the 10% subsample showed a correlation of 0...
December 2016: Data in Brief
Jean Golding, Steven Gregory, Alan Emond, Yasmin Iles-Caven, Joseph Hibbeln, Caroline M Taylor
BACKGROUND: There is considerable discussion over the possible harm caused by fetal exposure to mercury, but evidence of such harm is contradictory at levels commonly found in populations with moderate intakes of fish. Further information is needed to inform debate and clarify policy recommendations. MATERIAL: Data were collected prospectively for the Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood taken in the first half of pregnancy was assayed for mercury...
September 12, 2016: Neurotoxicology
Suzanne Audrey, Lindsey Brown, Rona Campbell, Andy Boyd, John Macleod
BACKGROUND: Avon Longitudinal Study of Parents and Children (ALSPAC) is a birth cohort study within which the Project to Enhance ALSPAC through Record Linkage (PEARL) was established to enrich the ALSPAC resource through linkage between ALSPAC participants and routine sources of health and social data. PEARL incorporated qualitative research to seek the views of young people about data linkage, including their opinions about appropriate safeguards and research governance. In this paper we focus on views expressed about the purpose and composition of research ethics committees...
2016: BMC Medical Ethics
Tom G Richardson, Hashem A Shihab, Gibran Hemani, Jie Zheng, Eilis Hannon, Jonathan Mill, Elena Carnero-Montoro, Jordana T Bell, Oliver Lyttleton, Wendy L McArdle, Susan M Ring, Santiago Rodriguez, Colin Campbell, George Davey Smith, Caroline L Relton, Nicholas J Timpson, Tom R Gaunt
BACKGROUND: Single variant approaches have been successful in identifying DNA methylation quantitative trait loci (mQTL), although as with complex traits they lack statistical power to identify effects from rare genetic variants. We have undertaken extensive analyses to identify regions of low frequency and rare variants that are associated with DNA methylation levels. METHODS: We used repeated measurements of DNA methylation from five different life stages in human blood, taken from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort...
August 24, 2016: Human Molecular Genetics
Evie Stergiakouli, Anita Thapar, George Davey Smith
Importance: Acetaminophen (paracetamol) is used by a large proportion of pregnant women. Research suggests that acetaminophen use in pregnancy is associated with abnormal fetal neurodevelopment. However, it is possible that this association might be confounded by unmeasured behavioral factors linked to acetaminophen use. Objective: To examine associations between offspring behavioral problems and (1) maternal prenatal acetaminophen use, (2) maternal postnatal acetaminophen use, and (3) partner's acetaminophen use...
October 1, 2016: JAMA Pediatrics
Kaidy Stautz, Rachel Pechey, Dominique-Laurent Couturier, Ian J Deary, Theresa M Marteau
OBJECTIVE: Executive function, impulsivity, and intelligence are correlated markers of cognitive resource that predict health-related behaviours. It is unknown whether executive function and impulsivity are unique predictors of these behaviours after accounting for intelligence. METHODS: Data from 6069 participants from the Avon Longitudinal Study of Parents and Children were analysed to investigate whether components of executive function (selective attention, attentional control, working memory, and response inhibition) and impulsivity (parent-rated) measured between ages 8 and 10, predicted having ever drunk alcohol, having ever smoked, fruit and vegetable consumption, physical activity, and overweight at age 13, after accounting for intelligence at age 8 and childhood socioeconomic characteristics...
2016: PloS One
T J Cole, D Kuh, W Johnson, K A Ward, L D Howe, J E Adams, R Hardy, K K Ong
BACKGROUND: To explore associations between pubertal growth and later bone health in a cohort with infrequent measurements, using another cohort with more frequent measurements to support the modelling, data from the Medical Research Council (MRC) National Survey of Health and Development (2-26 years, 4901/30 004 subjects/measurements) and the Avon Longitudinal Study of Parents And Children (ALSPAC) (5-20 years) (10 896/74 120) were related to National Survey of Health and Development (NSHD) bone health outcomes at 60-64 years...
July 27, 2016: International Journal of Epidemiology
Mila Kingsbury, Murray Weeks, Nathalie MacKinnon, Jonathan Evans, Liam Mahedy, Jennifer Dykxhoorn, Ian Colman
OBJECTIVE: The fetal programming hypothesis posits that in utero exposure to stress can alter prenatal brain development and lifelong stress response. However, human studies linking objective prenatal stressors to offspring mental illness, especially depression, are rare. The purpose of this study was to examine the association between mothers' exposure to prenatal stressful life events (SLEs) and offspring depression. METHOD: The sample comprised 10,569 members of a prospective population-based cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC)...
August 2016: Journal of the American Academy of Child and Adolescent Psychiatry
A J Wright, O Fletcher, D Scrutton, G Baird
INTRODUCTION: The attainment of continence is an important milestone in all children, including those with disability. OBJECTIVE: To describe the age of bladder and bowel continence in children with bilateral cerebral palsy (BCP), and the association with intellectual impairment (II) and severity of motor disability. PATIENTS AND METHODS: The parents of 346 children with BCP were interviewed as part of a population-based prospective study of the children at 3, 7, and 17 years of age...
June 11, 2016: Journal of Pediatric Urology
Caroline Siebald, Golam M Khandaker, Stanley Zammit, Glyn Lewis, Peter B Jones
BACKGROUND: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. METHOD: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8years...
August 2016: Comprehensive Psychiatry
Jonathan Scourfield, Iryna Culpin, David Gunnell, Caroline Dale, Carol Joinson, Jon Heron, Simon M Collin
Evidence suggests that the quality of fathers' parenting has an impact on psychological outcomes during adolescence, but less is known about which aspects of fathering have the strongest effects. This study, using the Avon Longitudinal Study of Parents and Children (ALSPAC), considers which paternal attitudes towards and experiences of child care in infancy are most strongly associated with depressive symptoms in adolescence, and whether father effects are independent of maternal influence and other risk factors...
August 2016: Child Abuse & Neglect
Monika Frysz, Kevin Deere, Debbie A Lawlor, Li Benfield, Jon H Tobias, Celia L Gregson
Osteoporosis and cardiovascular disease(CVD) are both common causes of morbidity and mortality. Previous studies, mainly of people over 60 years, suggest a relationship between these conditions. Our aim was to determine the association between bone characteristics and CVD markers in younger and middle-aged individuals. Women (n = 3,366) and their adolescent offspring (n= 4,368) from the UK population-based cohort study, Avon Longitudinal Study of Parents and Children(ALSPAC), were investigated. We measured total body(TB) and hip BMD, TB bone area(BA) and bone mineral content(BMC) by DXA, and carotid intima-media thickness(cIMT) by high-resolution ultrasound...
June 30, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Nadia Micali, N J Horton, R D Crosby, S A Swanson, K R Sonneville, F Solmi, J P Calzo, K T Eddy, A E Field
Diagnostic criteria for eating disorders (ED) remain largely based on clinical presentations, but do not capture the full range of behaviours in the population. We aimed to derive an empirically based ED behaviour classification using behavioural and body mass index (BMI) indicators at three time-points in adolescence, and to validate classes investigating prospective associations with adverse outcomes. Adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) provided data on ED at age 14 (n = 6615), 16 (n = 5888), and 18 years (n = 5100), and had weight and height measured...
June 24, 2016: European Child & Adolescent Psychiatry
Caroline J Bull, Kate Northstone
OBJECTIVE: To investigate the prospective associations between dietary patterns in childhood and CVD risk in adolescence. DESIGN: Prospective cohort study. Exposures were dietary patterns at age 7, 10 and 13 years derived by cluster analysis. Outcomes were physiological and biochemical cardiovascular risk markers. SETTING: Avon Longitudinal Study of Parents and Children (ALSPAC), UK. SUBJECTS: Children (n 2311, 44.1 % male) with complete data available...
June 24, 2016: Public Health Nutrition
Alison Teyhan, Rosie Cornish, Andy Boyd, Mary Sissons Joshi, John Macleod
BACKGROUND: Cycle accidents are a common cause of physical injury in children and adolescents. Education is one strategy to reduce cycle-related injuries. In the UK, some children undertake National Cycle Proficiency Scheme [NCPS] training (now known as Bikeability) in their final years of primary school. It aims to promote cycling and safe cycling behaviours but there has been little scientific evaluation of its effectiveness. METHODS: The sample (n = 5415) were participants in the Avon Longitudinal Study of Parents and Children who reported whether or not they had received NCPS training...
2016: BMC Public Health
Caroline M Taylor, Kate Tilling, Jean Golding, Alan M Emond
BACKGROUND: National and international guidelines on safe levels for blood Pb in pregnancy focus on a threshold above which exposure is of concern. However, it has recently been suggested that the decrease in birth weight per unit increase in blood Pb is actually greater at lower than at higher concentrations of Pb without evidence of a lower threshold of effect. Our aim was to investigate whether there was evidence for a differential effect of maternal Pb levels on birth outcomes and/or a threshold value for effects...
2016: BMC Research Notes
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