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https://www.readbyqxmd.com/read/28551787/mechanistic-role-of-mptp-in-ischemia-reperfusion-injury
#1
Giampaolo Morciano, Massimo Bonora, Gianluca Campo, Giorgio Aquila, Paola Rizzo, Carlotta Giorgi, Mariusz R Wieckowski, Paolo Pinton
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. The treatment of choice for reducing ischemic injury and limiting infarct size (IS) in patients with ST-segment elevation MI (STEMI) is timely and effective myocardial reperfusion via primary percutaneous coronary intervention (PCI). However, myocardial reperfusion itself may induce further cardiomyocyte death, a phenomenon known as reperfusion injury (RI). The opening of a large pore in the mitochondrial membrane, namely, the mitochondrial permeability transition pore (mPTP), is widely recognized as the final step of RI and is responsible for mitochondrial and cardiomyocyte death...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551688/nutrition-of-infants-and-young-children-in-poland-pitnuts-2016
#2
Halina Weker, Marta Barańska, Agnieszka Riahi, Małgorzata Strucińska, Małgorzata Więch, Grażyna Rowicka, Hanna Dyląg, Witold Klemarczyk, Agnieszka Bzikowska, Piotr Socha
The study evaluating the feeding practices and the nutritional status of children aged 5 to 36 months in a general, Polish, representative population (n=1059) was carried out from May to July 2016. The aim of this study was to evaluate the feeding practices in children aged 5 to 36 months with regard to models of safe nutrition on the basis of the outcome of the population study performed in 2016. The data obtained show that the feeding practices in children in their first year of life do not meet the guidelines presented in the model of safe nutrition, particularly in matters of timing of complementary feeding introduction and food choice...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28551410/perceptions-and-attitudes-of-community-pharmacists-toward-professional-ethics-and-ethical-dilemmas-in-the-workplace
#3
Jadranka Vuković Rodríguez, Živka Juričić
BACKGROUND: Formal training in pharmacy ethics is relatively new in Croatia, and the professional code of ethics is more than 20 years old. Very little is known about how practicing pharmacists implement ethical considerations and relevant professional guidelines in their work. OBJECTIVES: This study aimed to provide the first description of the perceptions and attitudes of Croatian community pharmacists toward ethics in pharmacy practice, how often they face certain ethical dilemmas and how they resolve them...
May 22, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28551364/barriers-and-attitudes-to-research-among-residents-in-plastic-and-reconstructive-surgery-a-national-multicenter-cross-sectional-study
#4
The Canadian Plastic Surgery Research, Sarah Al Youha, Becher Alhalabi, Jill Stone, Helene Retrouvey, Osama Samargandi, Johnny Ionut Efanov, Michael Stein, Alexander Morzycki, Haley Augustine, Emilie Bougie, Diana Song, Hollie Power, Julian Diaz-Abele, Caitlin Symonette, Marie Noland, Chris Coroneos, Sophocles Voineskos, Joshua Vorstenbosch, Toni Zhong, Michael Bezuhly, Jason G Williams
OBJECTIVE: Research sets the foundation for developing plastic surgeons who think critically and approach clinical practice with an inquisitive mind. The objective of this study was to characterize current attitudes and perceived barriers towards conducting research during residency. DESIGN: A validated 36-item questionnaire was developed by a national task-force of Canadian plastic surgery trainees. The survey was distributed to all 13 plastic surgery programs in Canada...
May 24, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28551278/reducing-construction-waste-a-study-of-urban-infrastructure-projects
#5
REVIEW
Ruane Fernandes de Magalhães, Ângela de Moura Ferreira Danilevicz, Tarcisio Abreu Saurin
The construction industry is well-known for producing waste detrimental to the environment, and its impacts have increased with the development process of cities. Although there are several studies focused on the environmental impact of residential and commercial buildings, less knowledge is available regarding decreasing construction waste (CW) generation in urban infrastructure projects. This study presents best practices to reduce waste in the said projects, stressing the role of decision-making in the design stage and the effective management of construction processes in public sector...
May 24, 2017: Waste Management
https://www.readbyqxmd.com/read/28551193/drivers-of-choice-for-fluid-milk-versus-plant-based-alternatives-what-are-consumer-perceptions-of-fluid-milk
#6
K S McCarthy, M Parker, A Ameerally, S L Drake, M A Drake
Fluid milk consumption has declined for decades while consumption of nondairy alternatives has increased. A better understanding of why consumers purchase fluid milk or nondairy alternatives is needed to assist increased sales of milk or maintain sales without further decline. The objective of this study was to determine the extrinsic attributes that drive purchase within each product category. The second objective was to determine the personal values behind the purchase of each beverage type to give further understanding why particular attributes are important...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551149/advanced-predictive-methods-for-wine-age-prediction-part-i-a-comparison-study-of-single-block-regression-approaches-based-on-variable-selection-penalized-regression-latent-variables-and-tree-based-ensemble-methods
#7
Ricardo Rendall, Ana Cristina Pereira, Marco S Reis
In this paper we test and compare advanced predictive approaches for estimating wine age in the context of the production of a high quality fortified wine - Madeira Wine. We consider four different data sets, namely, volatile, polyphenols, organic acids and the UV-vis spectra. Each one of these data sets contain chemical information of a different nature and present diverse data structures, namely a different dimensionality, level of collinearity and degree of sparsity. These different aspects may imply the use of different modelling approaches in order to better explore the data set's information content, namely their predictive potential for wine age...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551058/-anesthesia-recovery-comparison-between-remifentanil-propofol-and-remifentanil-desflurane-guided-by-bispectral-index-%C3%A2-monitoring
#8
Raphael Grossi Rocha, Eduardo Giarola Almeida, Lara Moreira Mendes Carneiro, Natália Farias de Almeida, Walkíria Wingester Vilas Boas, Renato Santiago Gomez
BACKGROUND AND OBJECTIVES: There is a strong demand for fast and predictable anesthesia recovery with few side effects. Choice of the hypnotic agent could impact on that. This study investigated the differences between recoveries after remifentanil-propofol and remifentanil-desflurane anesthesias guided by bispectral index (BIS(®)). METHODS: Forty patients were randomly assigned into 2 groups according to the anesthesia technique applied: remifentanil-propofol (REM-PRO) and remifentanil-desflurane (REM-DES)...
May 25, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28551035/examining-the-role-of-patient-values-in-decisions-about-long-term-enteral-feeding-a-qualitative-study
#9
Sean White, Louise Brereton
BACKGROUND & AIMS: Although studies demonstrate the range of impacts of home enteral feeding (HEF) on patients' lives, a dearth of evidence focussing on the decision to have a gastrostomy placed exists. The importance of taking account of patient values (i.e. their unique preferences, concerns and expectations) when considering the consequences of clinical decisions is increasingly recognised. This study explores patient's views on the role of their values in their decision to have a gastrostomy...
May 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28550824/-analysis-of-the-cochrane-review-topical-treatments-for-scalp-psoriasis-cochrane-database-syst-rev-2016-2-cd009687
#10
Catarina Soares Queirós, Gonçalo Silva Duarte, João Costa, António Vaz-Carneiro
Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis...
March 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28550817/atypical-presentation-and-outcome-of-cervicogenic-headache-in-patients-with-cervical-degenerative-disease-a-single-center-experience
#11
Shyamal C Bir, Anil Nanda, Devi Prasad Patra, Tanmoy Kumar Maiti, Cesar Liendo, Minagar Alireza, Oleg Y Chernyshev
OBJECTIVE: Cervicogenic headache affects a significant portion of the entire population. This type of headache especially with atypical presentation is often hard to diagnose and manage since its etiopathophysiology is not been yet well understood. We have investigated the prevalence of cervicogenic headache with atypical presentation and discussed the etiology of it, and the outcome of surgical intervention on this type of headache in patients with cervical degenerative disease. PATIENTS AND METHODS: Radiological and clinical data of 160 patients (from 2001 through 2016) were retrospectively reviewed...
May 13, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28550777/disolved-organic-matter-dom-removal-from-bio-treated-coking-wastewate-using-a-new-polymeric-adsorbent-modified-with-dimethylamino-groups
#12
Wenlan Yang, Chengda He, Xiaozhi Wang, Ya Zhang, Zhipeng Cheng, Benlin Dai, Lili Zhang
In the current study a new recyclable aminated hyper-cross-linked polymeric adsorbent (A-HPA) was prepared for effective removal of DOM from BTCW. Possibly benefited from its unique structure of polystyrene matrix, sufficient aminated groups and high specific surface area, A-HPA could remove DOM from BTCW through the synergetic effect of π-π interactions, acid-base interactions and micropore filling, and exhibited the highest removal efficiency than the other adsorbents. Moreover, the exhausted A-HPA was amenable to effective regeneration by using acid and alkaline solution, allowing for repeated use with a constant removal efficiency...
May 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28550603/development-of-novel-high-density-gastroretentive-multiparticulate-pulsatile-tablet-of-clopidogrel-bisulfate-using-quality-by-design-approach
#13
Nilesh Desai, Ravindra Purohit
Myocardial infarction, i.e., heart attack, is a fatal condition which is on the increase all over the world. It is reported that a large number of heart attack occur in morning hours which are attributable to platelet aggregation. Chronotherapy at this stage can be crucial. Clopidogrel bisulfate (CLB) is an antiplatelet agent and has become a drug of choice for prevention of heart attack. It is soluble in acidic pH and has a narrow absorption window. So, its long residence time in stomach is desirable. Therefore, a novel high density tablet was developed comprising multiparticulate pellets with pulsatile release necessary to maintain chronotherapy of heart attack...
May 26, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28550586/stress-echocardiography-with-smartphone-real-time-remote-reading-for-regional-wall-motion
#14
Maria Chiara Scali, Clarissa Carmona de Azevedo Bellagamba, Quirino Ciampi, Iana Simova, José Luis de Castro E Silva Pretto, Ana Djordjevic-Dikic, Claudio Dodi, Lauro Cortigiani, Angela Zagatina, Paolo Trambaiolo, Marco R Torres, Rodolfo Citro, Paolo Colonna, Marco Paterni, Eugenio Picano
The diffusion of smart-phones offers access to the best remote expertise in stress echo (SE). To evaluate the reliability of SE based on smart-phone filming and reading. A set of 20 SE video-clips were read in random sequence with a multiple choice six-answer test by ten readers from five different countries (Italy, Brazil, Serbia, Bulgaria, Russia) of the "SE2020" study network. The gold standard to assess accuracy was a core-lab expert reader in agreement with angiographic verification (0 = wrong, 1 = right)...
May 26, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28550406/statistical-shape-modelling-to-aid-surgical-planning-associations-between-surgical-parameters-and-head-shapes-following-spring-assisted-cranioplasty
#15
Naiara Rodriguez-Florez, Jan L Bruse, Alessandro Borghi, Herman Vercruysse, Juling Ong, Greg James, Xavier Pennec, David J Dunaway, N U Owase Jeelani, Silvia Schievano
PURPOSE: Spring-assisted cranioplasty is performed to correct the long and narrow head shape of children with sagittal synostosis. Such corrective surgery involves osteotomies and the placement of spring-like distractors, which gradually expand to widen the skull until removal about 4 months later. Due to its dynamic nature, associations between surgical parameters and post-operative 3D head shape features are difficult to comprehend. The current study aimed at applying population-based statistical shape modelling to gain insight into how the choice of surgical parameters such as craniotomy size and spring positioning affects post-surgical head shape...
May 26, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28550310/a-to-i-editing-in-human-mirnas-is-enriched-in-seed-sequence-influenced-by-sequence-contexts-and-significantly-hypoedited-in-glioblastoma-multiforme
#16
Deepanjan Paul, Ashis Narayan Sinha, Arjun Ray, Megha Lal, Subhashree Nayak, Anchal Sharma, Bharati Mehani, Debasish Mukherjee, Saurabh V Laddha, Ashish Suri, Chitra Sarkar, Arijit Mukhopadhyay
Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs. These events were enriched in seed sequence (73.33%), which was not observed for cytosine to uracil (17.86%) editing. More than half of the edited miRNAs showed increased stability, 72.7% of which had ΔΔG values less than -6.0 Kcal/mole and for all of them the edited adenosines mis-paired with cytosines on the pre-miRNA structure...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550294/advantages-and-problems-of-nonlinear-methods-applied-to-analyze-physiological-time-signals-human-balance-control-as-an-example
#17
Wolfram Müller, Alexander Jung, Helmut Ahammer
Physiological processes are regulated by nonlinear dynamical systems. Various nonlinear measures have frequently been used for characterizing the complexity of fractal time signals to detect system features that cannot be derived from linear analyses. We analysed human balance dynamics ranging from simple standing to balancing on one foot with closed eyes to study the inherent methodological problems when applying fractal dimension analysis to real-world signals. Higuchi dimension was used as an example. Choice of measurement and analysis parameters has a distinct influence on the computed dimension...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28549994/intramedullary-nails-versus-sliding-hip-screws-for-ao-ota-31-a2-trochanteric-fractures-in-adults-a-meta-analysis
#18
REVIEW
Qianzheng Zhu, Xiaodong Xu, Xi Yang, Xingzuo Chen, Liqiang Wang, Chenggang Liu, Peng Lin
OBJECTIVES: The optimum treatment with intramedullary nails (IMN) or sliding hip screws (SHS) for type 31-A2 trochanteric fractures remains controversial. Therefore, we performed a meta-analysis of randomized controlled trials (RCTs) to compare IMN with SHS in AO/OTA 31-A2 trochanteric fractures. MATERIAL AND METHODS: Databases including PubMed, Cochrane, and Embase were searched to identify RCTs published before December 2016, which compared IMN with SHS for intraoperative and postoperative outcomes in AO/OTA 31-A2 trochanteric fractures...
May 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28549929/pragmatic-trials-and-real-world-evidence-an-introduction-to-the-series
#19
Mira Zuidgeest, Iris Goetz, Rolf Groenwold, Elaine Irving, Ghislaine van Thiel, Diederick E Grobbee
This is the introductory paper in a series of 8 papers (see box). In this series we integrate the theoretical design options with the practice of conducting pragmatic trials. For most new market-approved treatments the clinical evidence is insufficient to fully guide physicians and policy makers in choosing the optimal treatment for their patients. Pragmatic trials can fill this gap, by providing evidence on the relative effectiveness of a treatment strategy in routine clinical practice, already in an early phase of development, while maintaining the strength of randomized controlled trials...
May 23, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28549928/speed-mentoring-an-innovative-method-to-meet-the-needs-of-the-young-surgeon
#20
Rebecca C Britt, Amy N Hildreth, Shannon N Acker, Nicolas J Mouawad, Joshua Mammen, Jacob Moalem
OBJECTIVE: Speed mentoring has recently been used by several medical organizations as a strategy to establish mentoring relationships, which are felt to be critically important in the development of the surgeon. This study assesses a surgical speed-mentoring program at the 2015 American College of Surgeons (ACS) Clinical Congress. DESIGN: A steering committee designed the speed-mentoring program to match 60 ACS Resident and Associate Society mentees with a mix of junior and senior leadership of ACS...
May 23, 2017: Journal of Surgical Education
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