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https://www.readbyqxmd.com/read/29156792/liquid-biopsy-in-colon-cancer-comparison-of-different-circulating-dna-extraction-systems-following-absolute-quantification-of-kras-mutations-using-intplex-allele-specific-pcr
#1
Vera Kloten, Nadine Rüchel, Nadina Ortiz Brüchle, Janina Gasthaus, Nils Freudenmacher, Florian Steib, Jolein Mijnes, Julian Eschenbruch, Marcel Binnebösel, Ruth Knüchel, Edgar Dahl
Non-invasive molecular analysis of circulating tumor DNA (ctDNA) is a promising application in personalized cancer management, although there is still much to learn about the biological characteristics of ctDNA. The present study compared absolute amounts of KRAS mutated ctDNA and total circulating cell-free DNA (cfDNA) in colorectal cancer (CRC) patients (n=50) from various stages and healthy controls (n=8) by Intplex allele-specific and digital droplet PCR. In addition, the impact of two prominent extraction techniques (silica-based membrane vs...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156756/mir-221-regulated-kit-level-by-wild-type-or-leukemia-mutant-runx1-a-determinant-of-single-myeloblast-fate-decisions-that-collectively-drives-or-hinders-granulopoiesis
#2
Stefano Rossetti, Michael J Anauo, Nicoletta Sacchi
RUNX1, a master transcription factor of hematopoiesis, was shown to orchestrate both cell proliferation and differentiation during granulopoiesis by regulating microRNAs (miRs). In this study, taking advantage of the miR-ON reporter system, we monitored first, how the granulocyte colony stimulation factor (GCSF) temporally modulates the concomitant level variation of miR-221 and one of its prototypic targets, the stem cell factor receptor KIT, in single 32D(miR-ON-221) myeloblasts expressing wild type RUNX1...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156490/-the-citizen-is-stepping-into-a-new-role-policy-interpretations-of-patient-and-public-involvement-in-finland
#3
Marjaana Jones, Ilkka Pietilä
Involving patients and the public in healthcare decision-making is on the policy agenda in several countries. The aim of our study was to describe and analyse the development of patient and public involvement from a policy perspective. We argue that the language of health policies can influence both the aims and the development of involvement methods. In this study health policy documents, which have guided the development of patient and public involvement in Finland have been analysed using methods of Membership Categorisation Analysis...
November 20, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29156372/psychometric-properties-of-the-intuitive-eating-scale-2-ies-2-in-a-culturally-diverse-hispanic-american-sample
#4
Jessica F Saunders, Kristin A Nichols-Lopez, Leslie D Frazier
BACKGROUND: Intuitive eating is an adaptive eating tendency consistently associated with positive physical and mental health outcomes, including lower risk for obesity and eating disorders (EDs). Obesity rates are disproportionately high in Hispanic American populations, yet the properties of intuitive eating remain to be examined in such samples. METHOD: The current study examined the psychometric properties of the Intuitive Eating Scale-2 (IES-2) in a Hispanic American sample of adult college students (N=482), and related IES-2 scores to levels of disordered eating, body mass index (BMI), fruit and vegetable consumption, and body shape satisfaction...
November 14, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/29156154/coconut-phytocompounds-inhibits-polyol-pathway-enzymes-implication-in-prevention-of-microvascular-diabetic-complications
#5
Devi Lekshmi Sheela, Puthiyaveetil Abdulla Nazeem, Arunaksharan Narayanankutty, R Muthangaparambil Shylaja, Sangeetha P Davis, Priyanga James, Ravisankar Valsalan, Thekkekara Devassy Babu, Achuthan C Raghavamenon
Coconut oil (CO), the primary choice of cooking purposes in the south Asian countries, is rich in medium chain saturated fatty acids, especially lauric acid (50-52%). The oil has high medicinal use in Ayurvedic system and known to contain polyphenolic antioxidants. Studies have reported that CO improves insulin sensitivity and shows hypoglycemic effect. However, there is no information regarding its effect on chronic diabetic complications including retinopathy and nephropathy is available. The secondary diabetic complications are mediated by the activation of polyol pathway, where aldose reductase (AR) plays crucial role...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29156140/automated-training-of-reaxff-reactive-force-fields-for-energetics-of-enzymatic-reactions
#6
Tomáš Trnka, Igor Tvaroska, Jaroslav Koca
Computational studies of the reaction mechanisms of various enzymes are nowadays based almost exclusively on hybrid QM/MM models. Unfortunately, the success of this approach strongly depends on the selection of the QM region, and computational cost is a crucial limiting factor. An interesting alternative is offered by empirical reactive molecular force fields, especially the ReaxFF potential developed by van Duin and co-workers. However, even though an initial parameterization of ReaxFF for biomolecules already exists, it does not provide the desired level of accuracy...
November 20, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29156015/european-prospective-multicentre-study-of-hybrid-thoracoscopic-and-transcatheter-ablation-of-persistent-atrial-fibrillation-the-historic-af-trial
#7
Claudio Muneretto, Gianluigi Bisleri, Fabrizio Rosati, Ralf Krakor, Laura Giroletti, Lorenzo Di Bacco, Alberto Repossini, Massimo Moltrasio, Antonio Curnis, Claudio Tondo, Gianluca Polvani
OBJECTIVES: The HISTORIC-AF trial is a prospective, multicentre, single-arm study designed to evaluate the outcomes of a staged endoscopic and transcatheter ablation in patients with stand-alone, persistent or long-standing persistent atrial fibrillation (AF). METHODS: From 2012 to 2015, 100 consecutive patients were enrolled and underwent thoracoscopic left atrial epicardial isolation ('box lesion') followed by transcatheter ablation in case of AF recurrency. The safety end point was the composite outcome of freedom from major adverse events at 30-days, while efficacy end points were: (i) primary: freedom from AF and stable sinus rhythm following isolated thoracospic ablation >60% and (ii) secondary: freedom from AF and stable sinus rhythm >80% following hybrid ablation (as per HRS criteria)...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155967/subcellular-metabolomics-the-choice-of-method-depends-on-the-aim-of-the-study
#8
Karl-Josef Dietz
No abstract text is available yet for this article.
November 16, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29155747/isolation-of-salmonella-typhimurium-containing-phagosomes-from-macrophages
#9
Saray Gutiérrez, Martina Wolke, Georg Plum, Nirmal Robinson
Salmonella typhimurium is a facultative intracellular bacterium that causes gastroenteritis in humans. After invasion of the lamina propria, S. typhimurium bacteria are quickly detected and phagocytized by macrophages, and contained in vesicles known as phagosomes in order to be degraded. Isolation of S. typhimurium-containing phagosomes have been widely used to study how S. typhimurium infection alters the process of phagosome maturation to prevent bacterial degradation. Classically, the isolation of bacteria-containing phagosomes has been performed by sucrose gradient centrifugation...
October 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155131/human-lung-epithelial-cell-cultures-for-analysis-of-inhaled-toxicants-lessons-learned-and-future-directions
#10
REVIEW
Pieter S Hiemstra, Gwendolynn Grootaers, Anne M van der Does, Cyrille A M Krul, Ingeborg M Kooter
The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in vitro cell culture models for analysis of the biological effects of inhaled toxicants. However, the validity of the current in vitro models and their acceptance by regulatory authorities as an alternative to animal models is a reason for concern, and requires a critical review...
November 15, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29155092/effects-of-medial-prefrontal-cortex-5-ht7-receptor-knockdown-on-cognitive-control-after-acute-heroin-administration
#11
Huijun Zhong, Jie Dang, Zhenghao Huo, Zhanbing Ma, Jing Chen, Yong Huang, Yongsheng Zhu, Min Li
Heroin abuse is linked to a deleterious effect on cognitive functioning in the individual. Recent evidences suggest that the serotonin7 receptor (5-HT7R) is engaged in the regulation of cognitive control and the drug use-associated behaviors. However, the role of 5-HT7R in the cognitive control after acute heroin administration has not been studied. The present study aims to investigate whether the knockdown of the 5-HT7R by virus-mediated gene silencing in the medial prefrontal cortex (mPFC) could ameliorate the acute heroin-induced cognitive impairments...
November 16, 2017: Brain Research
https://www.readbyqxmd.com/read/29155046/the-effect-of-a-default-based-nudge-on-the-choice-of-whole-wheat-bread
#12
Ellen van Kleef, Karen Seijdell, Monique H Vingerhoeds, René A de Wijk, Hans C M van Trijp
Consumer choices are often influenced by the default option presented. This study examines the effect of whole wheat bread as a default option in a sandwich choice situation. Whole wheat bread consists of 100% whole grain and is healthier than other bread types that are commonly consumed, such as brown or white bread. A pilot survey (N = 291) examined the strength of combinations of toppings and bread type as carrier to select stimuli for the main study. In the main experimental study consisting of a two (bread type) by two (topping type) between-subjects design, participants (N = 226) were given a free sandwich at a university stand with either a relatively unhealthy deep-fried snack (croquette) or a healthy topping...
November 15, 2017: Appetite
https://www.readbyqxmd.com/read/29154998/intraoperative-vertebroplasty-during-surgical-decompression-and-instrumentation-for-aggressive-vertebral-hemangiomas-a-retrospective-study-of-39-patients-and-review-of-the-literature
#13
Ben Wang, Song Bo Han, Liang Jiang, Xiao Guang Liu, Shao Min Yang, Na Meng, Feng Wei, Zhong Jun Liu
BACKGROUND CONTEXT: Aggressive (Enneking Stage 3, S3) vertebral hemangiomas (VHs) are rare, which might require surgery. However, the choice of surgery for S3 VHs remains controversial because of the rarity of these lesions. PURPOSE: We reported our experience of treating S3 VHs, and evaluated the effectiveness and safety of intraoperative vertebroplasty during decompression surgery for S3 VHs. STUDY DESIGN: This is a retrospective study. PATIENT SAMPLE: Thirty-nine patients with a definitive pathological diagnosis of aggressive VHs who underwent primary decompression surgery in our department were included in this study...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154887/food-consumption-when-travelling-abroad-young-chinese-sojourners-food-consumption-in-the-uk
#14
Dorothy Ai-Wan Yen, Benedetta Cappellini, Cheng Lu Wang, Bang Nguyen
This qualitative study investigates the everyday food choices of 21 Chinese sojourners living in two different localities in the UK. Findings from a thematic analysis of semi-structured interviews reveal how participants adopt a food consumption pattern, negotiating between ordinary and extraordinary food choices, including home-made Chinese food, Chinese restaurant food, global brands, British food, to "foods of the world". Their zooming in and out of different food consumption choices reflects the transformative identity of the sojourners, between their student role during the week and becoming tourists at the weekends, meshing work and tourism during their sojourning in the UK...
November 14, 2017: Appetite
https://www.readbyqxmd.com/read/29154685/a-qualitative-analysis-of-real-time-continuous-glucose-monitoring-data-sharing-with-care-partners-to-share-or-not-to-share
#15
Michelle L Litchman, Nancy A Allen, Vanessa D Colicchio, Sarah E Wawrzynski, Kerri M Sparling, Krissa L Hendricks, Cynthia A Berg
BACKGROUND: Little research exists regarding how real-time continuous glucose monitoring (RT-CGM) data sharing plays a role in the relationship between patients and their care partners. OBJECTIVE: To (1) identify the benefits and challenges related to RT-CGM data sharing from the patient and care partner perspective and (2) to explore the number and type of individuals who share and follow RT-CGM data. METHODS: This qualitative content analysis was conducted by examining publicly available blogs focused on RT-CGM and data sharing...
November 20, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29154635/you-have-to-hear-this-using-tone-of-voice-to-motivate-others
#16
Netta Weinstein, Konstantina Zougkou, Silke Paulmann
The present studies explored the role of prosody in motivating others, and applied self-determination theory (Ryan & Deci, 2000) to do so. Initial studies describe patterns of prosody that discriminate motivational speech. Autonomy support was expressed with lower intensity, slower speech rate and less voice energy in both motivationally laden and neutral (but motivationally primed) sentences. In a follow-up study, participants were able to recognize motivational prosody in semantically neutral sentences, suggesting prosody alone may carry motivational content...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154609/influence-of-sedentary-social-and-physical-alternatives-on-food-reinforcement
#17
Katelyn A Carr, Leonard H Epstein
OBJECTIVE: This study examined the potential for nonfood alternative activities to compete with the reinforcing value of food. Participants rated the frequency and pleasantness of engaging in a variety of activities and made hypothetical choices between food and 4 types of alternatives; cognitive-enriching (reading, listening to music), social (attending a party or event), sedentary (watching TV), and physically active (running, biking). METHOD: Two-hundred seventy-six adults completed an online survey using a crowdsourcing platform...
November 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29154529/consumer-perception-of-the-food-and-drug-administration-s-newest-recommended-food-facility-inspection-format-words-matter
#18
Jooho Kim, Jing Ma, Barbara Almanza
The Food and Drug Administration recommended restaurant inspection scores change to a format that incorporated three new categories of violations: priority, priority foundation, and core. It was uncertain whether interested consumers would value the more in-depth information or become more confused. The purpose of this study was to assess consumer perception of the recommended inspection system. Data were collected from an online survey. Results showed that consumers want convenient access to the information either online or on the wall of restaurants, and some consumers do want to read inspection reports and use them in making dining decisions...
June 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29154491/does-differential-visual-exploration-contribute-to-visual-memory-impairments-in-22q11-2-microdeletion-syndrome
#19
M Bostelmann, B Glaser, A Zaharia, S Eliez, M Schneider
BACKGROUND: Chromosome 22q11.2 microdeletion syndrome (22q11.2DS) is a genetic syndrome characterised by a unique cognitive profile. Individuals with the syndrome present several non-verbal deficits, including visual memory impairments and atypical exploration of visual information. In this study, we seek to understand how visual attention may contribute to memory difficulties in 22q11.2DS by tracking eye movements during the encoding phase of a visual short-term memory task. METHOD: Eye movements were recorded during a computerised version of the multiple-choice Benton Visual Retention Test, which consisted of exploring and then recognising complex visual stimuli...
December 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29154246/do-we-need-changes-in-the-organization-of-training-in-the-hernia-treatment-in-poland-a-survey-on-the-acknowledgment-of-the-recommendations-of-international-hernia-societies-by-surgeons
#20
Kryspin Mitura, Stanisław Dąbrowiecki, Maciej Śmietański, Andrzej Matyja
In the therapy of an inguinal hernia, there is a huge variety in the way of treating and the choice of surgical technique. Practice shows that the intraoperative improvisation and surgeons' own modifications of the original techniques have become part of routine procedure. No mandatory hernia registration system causes the actual detailed herniology status in our country remains unknown. The aim of the study was to summarize the results of a survey on knowledge of a hernia according to the standards developed by international hernia societies compared with everyday clinical practice...
October 31, 2017: Polski Przeglad Chirurgiczny
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