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https://www.readbyqxmd.com/read/29222799/middle-cerebral-artery-occlusion-by-an-intraluminal-suture-method
#1
Rosalia Crupi, Rosanna Di Paola, Emanuela Esposito, Salvatore Cuzzocrea
Stroke represents the most common fatal neurological disease especially in highly developed countries. Even today, treatment options are very limited. The development of new therapeutic approaches replies, to a great extent, on experimental rodent models of focal cerebral ischemia. Since ~80% of ischemic strokes occur in the area of middle cerebral artery (MCA), a number of these stroke models are based on this artery. The intraluminal monofilament model of MCA occlusion involves the insertion of a surgical filament inside the external carotid artery and its extension into the internal carotid artery until the tip occludes the source of the MCA-thus arresting blood flow with resultant infarction in the MCA area...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222757/rna-sequencing-and-analysis-in-microorganisms-for-metabolic-network-reconstruction
#2
Eva Pinatel, Clelia Peano
There is a strict interplay between metabolic networks and transcriptional regulation in bacteria; indeed, the transcriptome regulation, affecting the expression of large gene sets, can be used to predict the likely "on" or "off" state of metabolic genes as a function of environmental factors. Up to date, many bacterial transcriptomes have been studied by RNAseq, hundreds of experiments have been performed, and Giga bases of sequences have been produced. All this transcriptional information could potentially be integrated into metabolic networks in order to obtain a more comprehensive view of their regulation and to increase their prediction power...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222602/endoscopic-ultrasound-guided-biliary-drainage-using-a-newly-designed-metal-stent-with-a-thin-delivery-system-a-preclinical-study-in-phantom-and-porcine-models
#3
Kosuke Minaga, Masayuki Kitano, Masahiro Itonaga, Hajime Imai, Takeshi Miyata, Kentaro Yamao, Takashi Tamura, Junya Nuta, Kenji Warigaya, Masatoshi Kudo
PURPOSE: This study was designed to evaluate the feasibility and safety of a newly designed self-expandable metal stent for endoscopic ultrasound-guided biliary drainage (EUS-BD) when it was delivered via three different stent delivery systems: a 7.5Fr delivery catheter with a bullet-shaped tip (7.5Fr-bullet), a 7Fr catheter with a bullet-shaped tip (7Fr-bullet), or a 7Fr catheter with a tee-shaped tip (7Fr-tee). METHODS: This experimental study utilized a porcine model of biliary dilatation involving ten pigs...
December 8, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29222575/flexible-ureteroscopy-technique-tips-and-tricks
#4
REVIEW
Steeve Doizi, Olivier Traxer
During the last decades, the surgical management of kidney stones benefited of many technological advances and one of them is the development of flexible ureteroscopy (fURS). This tool, ancillary equipment such as graspers and baskets, and lithotripsy technique with Holmium:YAG laser underwent many improvements leading to a widening of its indications with diagnostic and therapeutic management of upper urinary tract pathologies such as urolithiasis and urothelial tumors. The objective of this review is to describe the surgical technique for fURS as well as tips and tricks for the treatment of renal stones...
December 8, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29222537/the-effects-of-palate-features-and-glossectomy-surgery-on-s-production
#5
Dana L Grimm, Maureen Stone, Jonghye Woo, Junghoon Lee, Jun-Hyuk Hwang, Gary E Bedrosian, Jerry L Prince
Purpose: The aims of this article were to determine the effects of hard palate morphology and glossectomy surgery on tongue position and shape during /s/ for patients with small tumors. The first expectation was that laminal /s/ would be more prevalent in patients, than apical, due to reduced tongue tip control after surgery. The second was that patients would hold the tongue more anteriorly than controls to compensate for reduced tongue mass. Method: Three-dimensional tongue volumes were calculated from magnetic resonance imaging for the whole tongue and the portion anterior to the first molar during the /s/ in /əsuk/ for 21 controls and 14 patients...
December 7, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29221679/the-gnathobasic-spine-microstructure-of-recent-and-silurian-chelicerates-and-the-cambrian-artiopodan-sidneyia-functional-and-evolutionary-implications
#6
Russell D C Bicknell, John R Paterson, Jean-Bernard Caron, Christian B Skovsted
Gnathobasic spines are located on the protopodal segments of the appendages of various euarthropod taxa, notably chelicerates. Although they are used to crush shells and masticate soft food items, the microstructure of these spines are relatively poorly known in both extant and extinct forms. Here we compare the gnathobasic spine microstructures of the Silurian eurypterid Eurypterus tetragonophthalmus from Estonia and the Cambrian artiopodan Sidneyiainexpectans from Canada with those of the Recent xiphosuran chelicerate Limulus polyphemus to infer potential variations in functional morphology through time...
December 5, 2017: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29221437/evolutionary-characterization-and-transcript-profiling-of-%C3%AE-tubulin-genes-in-flax-linum-usitatissimum-l-during-plant-development
#7
Floriana Gavazzi, Gaia Pigna, Luca Braglia, Silvia Gianì, Diego Breviario, Laura Morello
BACKGROUND: Microtubules, polymerized from alpha and beta-tubulin monomers, play a fundamental role in plant morphogenesis, determining the cell division plane, the direction of cell expansion and the deposition of cell wall material. During polarized pollen tube elongation, microtubules serve as tracks for vesicular transport and deposition of proteins/lipids at the tip membrane. Such functions are controlled by cortical microtubule arrays. Aim of this study was to first characterize the flax β-tubulin family by sequence and phylogenetic analysis and to investigate differential expression of β-tubulin genes possibly related to fibre elongation and to flower development...
December 8, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29221340/sudden-hypotension-occurring-after-4-days-of-left-sided-central-catheter-placement
#8
Youn-Jung Kim, Won Young Kim
Central venous catheters (CVCs) have an important role in the management of critically ill patients. In contrast to the immediate complications after CVC insertion, the late complications were difficult to be noticed without high suspicion despite their life-threatening outcome. We report a rare but fatal delayed vascular perforation occurring after 4 days of left-sided hemodialysis catheter insertion. A 74-year-old male with septic shock was treated with continuous renal replacement therapy (CRRT) and recovered smoothly during hospitalization...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221315/four-arm-robotic-assisted-pulmonary-resection-right-upper-lobectomy-how-to-do-it
#9
Alessandro Pardolesi, Luca Bertolaccini, Jury Brandolini, Piergiorgio Solli
Numerous published articles have shown the safety and efficacy of robotic lung resection, including lobectomy. Several techniques have been described by different authors to perform a robot assisted lung lobectomy. We adopted four arms robotic procedure. We usually perform three ports (10-15 mm) and an anterior 3 to 4 cm utility incision. This technique allows to safely proceed with an anterior to posterior approach to the hilum. In this study, we present in clear and sequential steps, the procedure to perform a right upper lobectomy for early stage lung cancer...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221310/uniportal-video-assisted-thoracoscopic-surgery-left-upper-lobe-trisegmentectomy-using-flexible-tip-3d-video-scope
#10
Mathew Thomas
A 69-year-old male patient with a history of melanoma and prostate cancer was found to have a 2.6 cm PET-avid, slowly enlarging, left upper lobe lung nodule that was suspicious for either metastasis or primary lung cancer. Due to the deep location of the nodule, a wedge resection was not recommended. A diagnostic and therapeutic uniportal video-assisted thoracoscopic surgery (U-VATS) left upper lobe trisegmentectomy was performed uneventfully. Final pathology confirmed the presence of metastasis from prostate cancer without lymph node involvement...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221053/ultra-high-speed-plif-imaging-for-simultaneous-visualization-of-multiple-species-in-turbulent-flames
#11
Zhenkan Wang, Panagiota Stamatoglou, Zheming Li, Marcus Aldén, Mattias Richter
In order to obtain more detailed characteristics and information in highly turbulent flames, for a better understanding of the transient behavior of eddies in such flames, a measurement technique with sufficient temporal resolution is requested. However, the probing of species distributions relevant in combustion (e.g. OH, CH2O) with ultra-high-speed laser diagnostics still remains a challenge. Nd:YAG clusters commercially available can generate only 4-8 pulses, although with high laser energy. Systems based on a diode-pumped solid-state Nd:YAG laser combined with a dye laser produce only about 100 μJ pulse energy at ultra-high repetition rates (≥50 kHz)...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29221027/development-of-a-unimorph-deformable-mirror-with-water-cooling
#12
Zhengxiong Zhu, Yan Li, Junjie Chen, Jianqiang Ma, Jiaru Chu
Deformable mirror (DM) used for intracavity compensation in high-power lasers should be able to withstand very high laser intensity. This paper proposes a water-cooled unimorph DM which can withstand the laser power up to 10 kW in thermal simulation. The proposed DM consists of an annular PZT layer and a circular Si layer which are glued together with edge clamped. All the 32 piezoelectric actuators are distributed around the correction area and on the front side of the DM. The cooling water flows through the back side of the DM and cools the mirror directly...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220186/detection-of-co2%C3%A2-in-the-electrochemical-reduction-of-carbon-dioxide-in-dmf-by-scanning-electrochemical-microscopy
#13
Tianhan Kai, Min Zhou, Zhiyao Duan, Graeme A Henkelman, Allen J Bard
The electrocatalytic reduction of CO2 has been studied extensively and produces a number of products. The initial reaction in the CO2 reduction is often taken to be the 1e formation of the radical anion, CO2·. However, the electrochemical detection and characterization of CO2· is challenging because of the short lifetime of CO2·, which can dimerize and react with proton donors and even mild oxidants. Here, we report the generation and quantitative determination of CO2· in N,N-dimethyl formamide (DMF) with the tip generation/substrate collection (TG/SC) mode of scanning electrochemical microscopy (SECM)...
December 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29220159/monolithic-nanoporous-in-sn-alloy-for-electrochemical-reduction-of-carbon-dioxide
#14
Wan Jae Dong, Chul Jong Yoo, Jong-Lam Lee
Nanostructured metal catalysts to convert CO2 to formate, which have been extensively studied over decades, have many problems such as durability, lifetime, high process temperature, and difficulty in controlling the morphology of nanostructures. Here, we report a facile method to fabricate monolithic nanoporous In-Sn alloy, a network of nanopores, induced by electroreduction of indium tin oxide nanobranches (ITO BRs). The electroreduction process concentrated a local electric field at the tip of the nanostructure, leading to current-assisted joule-heating to form a nanoporous In-Sn alloy...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29220002/a-tip-of-the-hat-to-evolutionary-change
#15
Charles R Marshall
No abstract text is available yet for this article.
December 7, 2017: Nature
https://www.readbyqxmd.com/read/29219800/-social-awareness-campaign-for-a-ban-on-consumer-fireworks-10-tips-doctor-on-the-barricade
#16
J T H N de Faber, M van Zuilen, M Snouck Hurgronje, J Keunen
- Describe the problem, and show why a social awareness campaign is needed- Know what you are talking about, and explain the medical jargon in plain language- Collect data and facts- Create support among colleagues- Get the media involved- Get support from the community- Create a coalition of supporters via a website- You will discover who the opposition is when you are on the barricade- Offer a safe and healthy alternative - Draw up a long-term roadmap, and persevere.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29218581/fabrication-of-tip-dissolving-microneedles-for-transdermal-drug-delivery-of-meloxicam
#17
Jianmin Chen, Weiyue Huang, Ziyao Huang, Shiqi Liu, Yaling Ye, Qinglian Li, Meiping Huang
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant time consumption, loss of drug activity, and difficulty in regulating MN drug loading. To address these issues, we developed the tip-dissolving (TD) MNs. Several kinds of drugs were encapsulated successfully, and the quantity of MX ranged from 37.23 ± 8.40 to 332.53 ± 13.37 μg was precisely controlled...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29218558/sas-based-studies-of-protein-fibrillation
#18
Carlotta Marasini, Bente Vestergaard
Protein fibrillation is associated with a number of fatal amyloid diseases (e.g. Alzheimer's and Parkinson's diseases). From a structural point of view, the aggregation process starts from an ensemble of native states that convert into transiently formed oligomers, higher order assemblies and protofibrils and, finally, fibrils. The different species exist in equilibrium in solution leading to a high degree of sample heterogeneity. It is impossible to physically isolate any single species for structural analysis: separation will alter the equilibrium and potentially cause structural changes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29218352/an-ultra-low-frictional-interface-combining-fdts-sams-with-molybdenum-disulfide
#19
Xing'an Cao, Xuehui Gan, Yitian Peng, Yongxia Wang, Xingzhong Zeng, Haojie Lang, Jinan Deng, Kun Zou
Interfacial friction is of crucial importance to ensure the friction-reducing and anti-wear properties of mechanical microstructures in micro/nanoelectromechanical systems (MEMS/NEMS). An ultra-low frictional interface combining hydrophobic 1H,1H,2H,2H-perfluorodecyltrichlorosilane (FDTS) self-assembled monolayers (SAMs) coated on an AFM tip with mechanically exfoliated molybdenum disulfide (MoS2) nanosheets deposited on a planar Si/SiO2 substrate was achieved. The FDTS SAMs/MoS2 interface between the FDTS SAMs and the MoS2 nanosheets exhibits an ultra-low friction force that is independent of the relative humidity...
December 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/29218287/use-of-forehead-flap-for-nasal-tip-reconstruction-after-traumatic-nasal-amputation
#20
Mohamad Ahmadi Moghadam, Shokofeh Ahmadi Moghadam
Nose is one of the most important aesthetic unit of the face.Management of nasal trauma plays a significant role in the practices of the majority of facial and reconstructive surgeons. Replantation, although technically very challenging, is undoubtedly the procedure of choice following traumatic nasal amputation. Here we present an illustrative case report of the traumatic amputation of a nasal tip that was treated successfully with a paramedian forehead flap and further nasal reconstructive surgery. Use of the forehead flap was performed five hours after the occurrence of trauma and was followed by surgical repair about three weeks later...
September 2017: World Journal of Plastic Surgery
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