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Pablo D Garcia, Ricardo Garcia
The elastic response of a living cell is affected by its physiological state. This property provides mechanical fingerprints of a cell's dysfunctionality. The softness (kilopascal range) and thickness (2-15 μm) of mammalian cells imply that the force exerted by the probe might be affected by the stiffness of the solid support. This observation makes infinite sample thickness models unsuitable to describe quantitatively the forces and deformations on a cell. Here, we report a general theory to determine the true Young's moduli of a single cell from a force-indentation curve...
June 19, 2018: Biophysical Journal
Remi Chauvin
Extension of a structure-activity relationship study of the antitumor cytotoxicity of lipidic dialkynylcarbinols (DACs) is envisaged by formal methinylogation of one of the ethyndiyl moieties of the DAC warhead into the corresponding allenylalkynylcarbinol (AllAC) counterpart. External AllACs were directly obtained by methynylation of the parent DACs with formaldehyde in either the racemic or scalemic series. Isomers containing external progargyl and propynyl motifs were also prepared. Internal AllACs were obtained as racemic statistical mixtures of stereoisomers in two steps from the key C5-DAC rac-TIPS-C≡C-CH(OH)-C≡CH and aldehydes...
June 20, 2018: ChemMedChem
Dogan Kaya, Jianzhi Gao, Mahroo Rokni-Fard, Richard E Palmer, Quanmin Guo
We report controlled manipulation of magic number gold-fullerene clusters, (C60)m-(Au)n, on a Au(111) substrate at 110 K using the scanning tunnelling microscope (STM). Each cluster consists of a two-dimensional gold island of n Au atoms confined by a frame of m C60 molecules. Using the STM, C60 molecules are extracted from the molecular frame one at a time. The extraction is conducted by driving the STM tip into the cluster leading to one of the molecules being squeezed out of the frame. Unlike at room temperature, the extracted molecules do not move away from the cluster due to the lack of thermal energy at 110 K, they are found to be attached to the outside of the frame...
June 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Christian-Hendrik Heeger, Christopher Schuette, Valentina Seitelberger, Erik Wissner, Andreas Rillig, Shibu Mathew, Bruno Reissmann, Christine Lemes, Tilman Maurer, Thomas Fink, Osamu Inaba, Naotaka Hashiguchi, Francesco Santoro, Feifan Ouyang, Karl-Heinz Kuck, Andreas Metzner
BACKGROUND: The second-generation cryoballoon (CB2) provides effective and durable pulmonary vein isolation (PVI) associated with encouraging and reproducible clinical outcome data. The latest-generation cryoballoon (CB3) incorporates a 40% shorter distal tip, thus allowing for an increased rate of PVI real-time signal recording and facilitating individualized ablation strategies taking the time-to-effect (TTE) into account. However, whether this characteristic translates into favorable clinical success has not been evaluated yet...
June 20, 2018: Cardiology Journal
Sushil F Sancheti, Vishal Uppal, Robert Sandeski, M Kwesi Kwofie, Jennifer J Szerb
BACKGROUND AND OBJECTIVES: Retroclavicular block is designed to overcome the negative aspects of the commonly utilized ultrasound-guided parasagittal approach to the infraclavicular block. However, this approach necessitates the needle traversing an area posterior to the clavicle inaccessible to ultrasound wave conduction. This study sought to document the structures vulnerable to needle injury during a retroclavicular block. METHODS: A Tuohy needle was inserted using a retroclavicular approach to the infraclavicular block in 3 lightly embalmed cadavers followed by a catheter insertion 4 cm beyond the needle tip...
June 19, 2018: Regional Anesthesia and Pain Medicine
Kathleen D Schaum
No abstract text is available yet for this article.
July 2018: Advances in Skin & Wound Care
Antje Kilias, Andres Canales, Ulrich P Froriep, Seongjun Park, Ulrich Egert, Polina Anikeeva
Optogenetic modulation of neural activity is a ubiquitous tool for basic investigation of brain circuits. While the majority of optogenetic paradigms rely on short light pulses to evoke synchronized activity of optically sensitized cells, many neurobiological processes are associated with slow local field potential (LFP) oscillations. Therefore, we developed a hybrid fiber probe capable of simultaneous electrophysiological recording and optical stimulation and used it to investigate the utility of sinusoidal light stimulation for evoking oscillatory neural activity in vivo across a broad frequency range...
June 20, 2018: Journal of Neural Engineering
Thomas Hermanns, Nico C Grossmann, Marian S Wettstein, Etienne X Keller, Christian D Fankhauser, Oliver Gross, Benedikt Kranzbühler, Martin Lüscher, Alexander H Meier, Tullio Sulser, Cédric Poyet
PURPOSE: To investigate whether heat-induced fiber degradation and loss of power output, which occurred during GreenLight laser vaporization (LV) of the prostate using the first- and second-generation 80 and 120 W laser, are still an issue during LV using the upgraded third generation 180 W GreenLight XPS™ laser. METHODS: Laser beam power output of 53 laser fibers was measured at baseline and after every 25 kJ of delivered energy during routine 180 W GreenLight XPS™ LV in 47 patients with prostatic bladder outflow obstruction...
June 19, 2018: World Journal of Urology
R Zorron, C Bures, A Brandl, P Seika, V Müller, M Alkhazraji, J Pratschke, M Mogl
BACKGROUND: Nowadays, minimally invasive thyroid and parathyroid gland resections for both benign and malignant tumors are rarely performed. Recently, promising new endoscopic transoral approaches to the anterior neck have been described with good results and few complications. This study describes the first clinical series in Germany using transoral endoscopic thyroidectomy-vestibular approach (TOETVA) and identifies technical issues and solutions. METHODS: The technique is indicated for hemithyroidectomy in patients without pre-existing neck operations...
June 19, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Alexey Lipatov, Haidong Lu, Mohamed Alhabeb, Babak Anasori, Alexei Gruverman, Yury Gogotsi, Alexander Sinitskii
Two-dimensional (2D) transition metal carbides and nitrides, known as MXenes, are a large class of materials that are finding numerous applications ranging from energy storage and electromagnetic interference shielding to water purification and antibacterial coatings. Yet, despite the fact that more than 20 different MXenes have been synthesized, the mechanical properties of a MXene monolayer have not been experimentally studied. We measured the elastic properties of monolayers and bilayers of the most important MXene material to date, Ti3 C2 T x (T x stands for surface termination)...
June 2018: Science Advances
Renato Moraes, Bruno L S Bedo, Luciana O Santos, Rosangela A Batistela, Paulo R P Santiago, Eliane Mauerberg-deCastro
This study investigated the effect of adding haptic information to the control of posture, as well as comparing the effect of both the "light touch" (LT) and "anchor system" (AS) paradigms on postural sway. Additionally, it compared the effect of location and number of points of contact to the control of posture in young adults. The location consisted of using the anchors tied to the finger and held by the hands, and, for LT, the fingertip. For the number of points of contact, participants used two hands, and then separately the dominant hand, and the non-dominant hand, for both anchor and LT paradigms...
2018: Frontiers in Neuroscience
Yufang Gao, Yuxiu Liu, Hui Zhang, Fang Fang, Lei Song
Background: Tip position verification of peripherally inserted central catheters (PICCs) is essential to the use of the catheter. Postprocedural chest X-ray as the "gold standard" practice for PICC tip confirmation can lead to a significant delay for patient IV therapy, cost more, and lead to radiation exposure for both patients and staffs. Intracavitary electrocardiogram (IC-ECG)-guided PICC placement which provides real-time tip confirmation during the insertion procedure has been widely used...
2018: Therapeutics and Clinical Risk Management
Korbinian Pürckhauer, Alfred J Weymouth, Katharina Pfeffer, Lars Kullmann, Estefania Mulvihill, Michael P Krahn, Daniel J Müller, Franz J Giessibl
High-resolution imaging of soft biological samples with atomic force microscopy (AFM) is challenging because they must be imaged with small forces to prevent deformation. Typically, AFM of those samples is performed with soft silicon cantilevers (k ≈ 0.1-10 N/m) and optical detection in a liquid environment. We set up a new microscope that uses a stiff qPlus sensor (k ≥ 1 kN/m). Several complex biologically-relevant solutions are non-transparent, and even change their optical properties over time, such as the cell culture medium we used...
June 19, 2018: Scientific Reports
Mariano Pellicano, Vincent Floré, Emanuele Barbato, Bernard De Bruyne
BACKGROUND: Percutaneous coronary interventions (PCI) of old calcified saphenous vein grafts (SVGs) is challenging and is associated with a considerably high risk of adverse ischemic events in the short- and long-term as compared to native coronary arteries. We report a case in which a non-dilatable, calcified SVG lesion is successfully treated with rotational atherectomy followed by PCI and stenting with local stent delivery (LSD) technique using the Guidezilla™ guide extension catheter (5-in-6 Fr) in the "child-in-mother" fashion...
June 19, 2018: BMC Cardiovascular Disorders
Justin Wee, Georges Azzie, James Drake, J Ted Gerstle
BACKGROUND: Mastering proper force manipulation in minimally invasive surgery can take many hours of practice and training. Improper force control can lead to necrosis, infection, and scarring. A force-sensing skin (FSS) has been developed, which measures forces at the distal end of minimal access surgeries' (MAS) instruments without altering the instrument's structural integrity or the surgical workflow, and acts as a minimally disruptive add-on to any MAS instrument. METHODS: A proof of concept study was conducted using a FSS-equipped 5 mm straight-tip needle holder...
June 19, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Orhan Ozturan, Alper Yenigun, Selahattin Tugrul, Fadlullah Aksoy
Nasal dorsal irregularity is a common postrhinoplasty complication in spite of meticulous smoothing. Utilization of the dermocartilaginous ligament in 2 different fashions for different purposes was described before. A novel utilization of the dermocartilaginous ligament as a flattened and pedicled flap from the cephalic attachment for nasal dorsal irregularities was presented in this article. This surgical technique was applied in 11 cases. Eight of them had thin skin, 2 had skin with medium thickness, and 1 had thick skin...
June 18, 2018: Journal of Craniofacial Surgery
Kevin A Henry, C Roger MacKenzie
Single-domain antibodies (sdAbs), the autonomous variable domains of heavy chain-only antibodies produced naturally by camelid ungulates and cartilaginous fishes, have evolved to bind antigen using only three complementarity-determining region (CDR) loops rather than the six present in conventional VH :VL antibodies. It has been suggested, based on limited evidence, that sdAbs may adopt paratope structures that predispose them to preferential recognition of recessed protein epitopes, but poor or non-recognition of protuberant epitopes and small molecules...
June 19, 2018: MAbs
R Lee Kirby, Amira Aggour, Audrey Chen, Cher Smith, Chris Theriault, Kara Matheson
PURPOSE: The tilt-rest skill consists of tipping the wheelchair back and allowing it to rest against a solid object with the wheel locks applied (e.g., for pressure redistribution, neck comfort or hands-free activities). The objective of this study was to determine the proportion of experienced manual wheelchair users who are aware of this skill and who can perform it. MATERIALS AND METHODS: We conducted a cross-sectional survey of 49 manual wheelchair users using a questionnaire developed for the purpose...
June 19, 2018: Disability and Rehabilitation. Assistive Technology
Coit T Hendley, Lee A Fielding, Elizabeth R Jones, Anthony J Ryan, Steven P Armes, Lara A Estroff
Recently, it has become clear that a range of nanoparticles can be occluded within single crystals to form nanocomposites. Calcite is a much-studied model, but even in this case we have yet to fully understand the details of the nanoscale interactions at the organic-inorganic interface that lead to occlusion. Here, a series of diblock copolymer nanoparticles with well-defined surface chemistries were visualized interacting with a growing calcite surface using in situ atomic force microscopy. These nanoparticles comprise a poly(benzyl methacrylate) (PBzMA) core-forming block and a non-ionic poly(glycerol monomethacrylate) (Ph-PGMA), a carboxylic acid-tipped poly(glycerol monomethacrylate) (HOOC-PGMA), or an anionic poly(methacrylic acid) (PMAA) stabilizer block...
June 19, 2018: Journal of the American Chemical Society
Seiichiro Abe, Ichiro Oda, Haruhisa Suzuki, Shigetaka Yoshinaga, Yutaka Saito
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
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