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https://www.readbyqxmd.com/read/29746172/pharmacological-decrease-of-liver-stiffness-is-pressure-related-and-predicts-long-term-clinical-outcome
#1
Felix Piecha, Mattias Mandorfer, Teresa Peccerella, Ann-Kathrin Ozga, Tanja Poth, Anna Vonbank, Helmut Karl Seitz, Vanessa Rausch, Thomas Reiberger, Sebastian Mueller
Liver stiffness (LS) as measured by transient elastography is increasingly used to non-invasively assess liver fibrosis. However, LS is efficiently modulated by confounders like arterial and portal pressure (PP). We here study the effect of acute hemodynamic changes on LS (measured by µFibroscan) in a rodent model of cirrhosis in response to pharmacological modulation of PP by losartan, NO-donors and propranolol. Additionally, changes of LS and the hepatic venous pressure gradient (HVPG) under propranolol therapy were assessed with regard to clinical outcomes in a human cohort of n=38 cirrhotic patients...
May 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29727387/a-return-to-harmful-alcohol-consumption-impacts-on-portal-hemodynamic-changes-following-alcoholic-hepatitis
#2
Laurent Spahr, Nicolas Goossens, Flavie Furrer, Melissa Dupuis, Sandrine Vijgen, Laure Elkrief, Emiliano Giostra, Laura Rubbia-Brandt, Jean-Louis Frossard
BACKGROUND: Increased hepatic venous pressure gradient (HVPG) plays a role in the clinical manifestations of alcoholic hepatitis (AH). The evolution of HVPG and the influence of alcohol use in the intermediate term are unclear. AIM: The aim of this study was to explore HVPG modifications following AH taking into consideration alcohol use and clinical manifestations. PATIENTS AND METHODS: Patients with AH (n=37; age 52 years; model for end-stage liver disease: 18...
April 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29726061/transjugular-diagnostics-in-acute-liver-failure-including-measurements-of-hepato-central-venous-biomarker-gradients
#3
Martin Chong Wang, Franziska Wandrer, Jerome Schlué, Torsten Voigtländer, Tim Oliver Lankisch, Michael Peter Manns, Heike Bantel, Thomas von Hahn
AIM: Acute liver failure (ALF) as a syndrome of severe liver injury may need urgent liver transplantation and is associated with significant risk of death. Therefore, early outcome prediction and further possibilities to increase accuracy of prognosis scores remain important. METHODS: We examined 30 patients with ALF according to the novel criteria of the Intractable Hepato-Biliary Diseases Study Group who underwent transjugular liver biopsy (TJLB) and investigated the relevance of histology for correct diagnosis and etiology...
May 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29723809/global-sensitivity-analysis-of-hepatic-venous-pressure-gradient-hvpg-measurement-with-a-stochastic-computational-model-of-the-hepatic-circulation
#4
Tianqi Wang, Fuyou Liang, Zunqiang Zhou, Xiaolong Qi
Hepatic venous pressure gradient (HVPG) is a widely employed surrogate of portal pressure gradient (PPG) in the diagnosis of portal hypertension (PHT). However, little is known about how HVPG measurement is affected by the complex vascular changes associated with PHT. In this study, we employed a computational method to quantitatively evaluate the sensitivity of HVPG measurement to various vascular factors involved in the development of sinusoidal PHT, aiming to provide a theoretical reference to guide the clinical application of HVPG measurement...
April 25, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29651703/spectrum-of-histopathological-changes-in-patients-with-non-cirrhotic-portal-fibrosis
#5
Abhijit Chougule, Archana Rastogi, Rakhi Maiwall, Chhagan Bihari, Vikrant Sood, Shiv Kumar Sarin
BACKGROUND AND AIMS: Non-cirrhotic portal fibrosis (NCPF) is a clinical disorder characterized by features of portal hypertension in the absence of significant fibrosis. It is one of the commonest causes of portal hypertension in India. This study aimed to analyze histomorphological spectrum of NCPF in detail. METHODS AND RESULTS: There were 67 specimens from 66 patients which included 43 (65.2%) male and 23 (34.8%) female patients with a mean age of 31 years (range: 7-61 years)...
April 12, 2018: Hepatology International
https://www.readbyqxmd.com/read/29603327/hepatocyte-microvesicle-levels-improve-prediction-of-mortality-in-patients-with-cirrhosis
#6
Audrey Payancé, Gilberto Silva-Junior, Julien Bissonnette, Marion Tanguy, Blandine Pasquet, Cristina Levi, Olivier Roux, Ouardia Nekachtali, Anna Baiges, Virginia Hernández-Gea, Cédric Laouénan, Didier Lebrec, Miguel Albuquerque, Valérie Paradis, Richard Moreau, Dominique Valla, François Durand, Chantal M Boulanger, Juan-Carlos Garcia-Pagan, Pierre-Emmanuel Rautou
Microvesicles (MVs) are extracellular vesicles released by cells following activation or apoptosis. Some MV subpopulations augment with cirrhosis severity and contribute to portal hypertension. This study aimed at determining if plasma MV levels can estimate the presence of hepatic venous pressure gradient (HVPG) ≥ 10 mmHg and predict mortality in patients with advanced chronic liver disease. All patients with severe fibrosis or cirrhosis undergoing liver catheterization between 2013 and 2015 at two centers were prospectively included...
March 30, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29570374/shear-wave-elastography-as-a-quantitative-biomarker-of-clinically-significant-portal-hypertension-a-systematic-review-and-meta-analysis
#7
Chong Hyun Suh, Kyung Won Kim, Seong Ho Park, Seung Soo Lee, Ho Sung Kim, Sree Harsha Tirumani, Jong Gu Lee, Junhee Pyo
OBJECTIVE: To qualify shear wave elastography (SWE) as a biomarker for clinically significant portal hypertension (CSPH) beyond proof of concept, we aimed to accumulate and summarize the current evidence through systematic review and meta-analysis. MATERIALS AND METHODS: A computerized literature search was performed to identify studies from MEDLINE and EMBASE up to February 9, 2017. Studies on the diagnostic performance of liver stiffness measurements using SWE for CSPH with hepatic venous pressure gradient (HVPG) as the reference standard were included...
May 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29545851/non-invasive-predictive-model-for-hepatic-venous-pressure-gradient-based-on-a-3-dimensional-computed-tomography-volume-rendering-technology
#8
Yujen Tseng, Lili Ma, Tiancheng Luo, Xiaoqing Zeng, Na Li, Yichao Wei, Ji Zhou, Feng Li, Shiyao Chen
Portal hypertension secondary to liver cirrhosis may cause a number of life-threatening complications. The rupture of gastroesophageal varices is associated with a high mortality rate of 15-30%. Hepatic venous pressure gradient (HVPG) is an accurate reflection of disease severity, however this can only be assessed via an invasive interventional procedure. The aim of the present study was to explore a non-invasive method based on 3D computed tomography (CT) volume rendering technology to accurately predict HVPG...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29492989/carvedilol-for-reducing-portal-pressure-in-primary-prophylaxis-of-variceal-bleeding-a-dose-response-study
#9
R Schwarzer, D Kivaranovic, R Paternostro, M Mandorfer, T Reiberger, M Trauner, M Peck-Radosavljevic, A Ferlitsch
BACKGROUND: Sequential measurements of hepatic venous pressure gradient (HVPG) are used to assess the haemodynamic response to nonselective betablockers (NSBBs) in patients with portal hypertension. AIMS: To assess the rates of HVPG response to different doses of carvedilol. METHODS: Consecutive patients with cirrhosis undergoing HVPG-guided carvedilol therapy for primary prophylaxis of variceal bleeding between 08/2010 and 05/2015 were retrospectively included...
April 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29470765/angiotensin-ii-receptor-blockers-for-the-treatment-of-portal-hypertension-in-patients-with-liver-cirrhosis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Huijing Yao, Chunqing Zhang
BACKGROUND: Randomized controlled trials (RCTs) showed inconsistent results regarding the efficacy of angiotensin II receptor blockers (ARBs) on portal pressure as indicated by hepatic venous pressure gradient (HVPG). METHODS: A meta-analysis of RCTs was performed to evaluate the influence of ARBs treatment on HVPG. PubMed, Embase, and Cochrane's Library were searched for relevant RCTs. A fixed or a randomized effect model was used to pool the results according the heterogeneity...
February 22, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29399280/collagen-proportionate-area-correlates-to-hepatic-venous-pressure-gradient-in-non-abstinent-cirrhotic-patients-with-alcoholic-liver-disease
#11
Sophie Restellini, Nicolas Goossens, Sophie Clément, Nicolas Lanthier, Francesco Negro, Laura Rubbia-Brandt, Laurent Spahr
AIM: To explore the relationship between collagen proportionate area (CPA) and portal hypertension-related clinical manifestations in alcoholic liver disease (ALD). METHODS: Retrospective study with chart review of patients with ALD adressed to our center between January 2012 and December 2013 for a transjugular liver biopsy (TJLB) and hepatic hemodynamic study. Patients were included if they met the following criteria: (1) Medical indication for a liver biopsy in the setting of ALD; (2) recent (< 15 d) clinical, radiological, endoscopic and biological data available; and (3) estimated follow-up of at least 6 mo...
January 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29385311/viral-eradication-and-fibrosis-resolution-in-post-liver-transplant-cholestatic-hepatitis-c-virus
#12
LETTER
Ezequiel Mauro, Gonzalo Crespo, Carla Montironi, Maria-Carlota Londoño, Alba Díaz, Xavier Forns, Miquel Navasa
No abstract text is available yet for this article.
May 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29377193/von-willebrand-factor-indicates-bacterial-translocation-inflammation-and-procoagulant-imbalance-and-predicts-complications-independently-of-portal-hypertension-severity
#13
M Mandorfer, P Schwabl, R Paternostro, K Pomej, D Bauer, J Thaler, C Ay, P Quehenberger, M Fritzer-Szekeres, M Peck-Radosavljevic, M Trauner, T Reiberger, A Ferlitsch
BACKGROUND: Elevated plasma von Willebrand factor antigen (vWF) has been shown to indicate the presence of clinically significant portal hypertension, and thus, predicts the development of clinical events in patients with cirrhosis. AIM: To investigate the impact of bacterial translocation and inflammation on vWF, as well as the association between vWF and procoagulant imbalance. Moreover, we assessed whether vWF predicts complications of cirrhosis, independent of the severity of portal hypertension...
April 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29368385/erectile-dysfunction-in-cirrhosis-is-impacted-by-liver-dysfunction-portal-hypertension-diabetes-and-arterial-hypertension
#14
Rafael Paternostro, Birgit B Heinisch, Thomas Reiberger, Mattias Mandorfer, Remy Schwarzer, Berit Seeland, Michael Trauner, Markus Peck-Radosavljevic, Arnulf Ferlitsch
BACKGROUND: Although several risk factors for erectile dysfunction may be present in patients with cirrhosis, data on the actual prevalence and cause of erectile dysfunction is limited. The International Index of Erectile Function-5 (IIEF-5) is a well-validated survey to determine the presence and severity of erectile dysfunction in men. We assessed (i) the prevalence and severity of erectile dysfunction, and (ii) risk factors for erectile dysfunction in patients with cirrhosis. METHODS: In this prospective study, erectile dysfunction was defined as: absent (>21 IIEF-5-points), mild (12-21) and severe (5-11)...
January 24, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29331339/cardiopulmonary-hemodynamics-and-c-reactive-protein-as-prognostic-indicators-in-compensated-and-decompensated-cirrhosis
#15
Laura Turco, Guadalupe Garcia-Tsao, Ilenia Magnani, Marcello Bianchini, Martina Costetti, Cristian Caporali, Stefano Colopi, Emilio Simonini, Nicola De Maria, Federico Banchelli, Rosario Rossi, Erica Villa, Filippo Schepis
BACKGROUND & AIMS: The main stages of cirrhosis (compensated and decompensated) have been sub-staged based on clinical, endoscopic, and portal pressure (determined by the hepatic venous pressure gradient [HVPG]) features. Vasodilation leading to a hyperdynamic circulatory state is central in the development of a late decompensated stage, with inflammation currently considered a key driver. We aimed to assess hepatic/systemic hemodynamics and inflammation (by C-reactive protein [CRP]) among the different sub-stages of cirrhosis and to investigate their interrelationship and prognostic relevance...
May 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29322599/non-invasive-evaluation-of-portal-hypertension-using-shear-wave-elastography-analysis-of-two-algorithms-combining-liver-and-spleen-stiffness-in-191-patients-with-cirrhosis
#16
L Elkrief, M Ronot, F Andrade, M Dioguardi Burgio, T Issoufaly, M Zappa, O Roux, J Bissonnette, A Payancé, D Lebrec, C Francoz, O Soubrane, D Valla, F Durand, V Vilgrain, L Castera, P-E Rautou
BACKGROUND: Two algorithms based on sequential measurements of liver and spleen stiffness using two-dimensional shearwave elastography (2D-SWE) have been recently proposed to estimate clinically significant portal hypertension (hepatic venous pressure gradient [HVPG] ≥10 mm Hg) in patients with cirrhosis, with excellent diagnostic accuracy. AIM: To validate externally these algorithms in a large cohort of patients with cirrhosis. METHODS: One hundred and ninety-one patients with stable cirrhosis (Child-Pugh class A 39%, B 29% and C 31%) who underwent liver and spleen stiffness measurements using 2D-SWE at the time of HVPG measurement were included...
March 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29316565/transjugular-intrahepatic-portosystemic-shunt-in-patients-with-portal-hypertension-patency-depends-on-coverage-and-interventionalist-s-experience
#17
Matthias Buechter, Paul Manka, Guido Gerken, Ali Canbay, Sandra Blomeyer, Axel Wetter, Jens Altenbernd, Alisan Kahraman, Jens M Theysohn
BACKGROUND AND AIMS: Transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice in decompensated portal hypertension. TIPS revision due to thrombosis or stenosis increases morbidity and mortality. Our aim was to investigate patient- and procedure-associated risk factors for TIPS-revision. PATIENTS AND METHODS: We retrospectively evaluated 189 patients who underwent the TIPS procedure. Only patients who required TIPS revision within 1 year (Group I, 34 patients) and patients who did not require re-intervention within the first year (Group II [control group], 54 patients) were included...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/29297975/clinical-characteristics-and-treatment-of-pyrrolizidine-alkaloid-related-hepatic-vein-occlusive-disease
#18
Yu Z Zhuge, Yi Wang, Feng Zhang, Cheng K Zhu, Wei Zhang, Ming Zhang, Qibin He, Jian Yang, Jian He, Jun Chen, Xiao P Zou
BACKGROUND AND AIMS: Hematopoietic stem cell transplantation related hepatic vein occlusive disease (HSCT-HVOD) has been researched extensively; however, little is known about the clinical features and treatment of pyrrolizidine alkaloid-induced HVOD (PA-HVOD). This retrospective single centre study examined the clinical and laboratory characteristics of 108 patients with acute PA-HVOD and explored the efficacy of anticoagulation and TIPS therapy. METHODS: The study included 108 consecutive patients with PA-HVOD between July 2008 and June 2016...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29246174/changes-of-liver-hemodynamic-and-elastography-parameters-in-patients-with-colorectal-liver-metastases-receiving-preoperative-chemotherapy-a-note-of-caution
#19
Amalia Pelegrina, Josep Martí, Rosa Miquel, Joana Ferrer, Virginia Hernández-Gea, Alba Diaz, Cristina Nadal, Juan Carlos García-Valdecasas, Josep Fuster
BACKGROUND: New systemic chemotherapy agents have improved prognosis in patients with colorectal liver metastases (CLM), but some of them damage the liver parenchyma and ultimately increase postoperative morbidity and mortality after liver resection. The aims of our study were to determine the degree of hemodynamic and pathological liver injury in CLM patients receiving preoperative chemotherapy and to identify an association between these injuries and postoperative complications after liver resection...
December 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29236785/the-soluble-mannose-receptor-smr-is-elevated-in-alcoholic-liver-disease-and-associated-with-disease-severity-portal-hypertension-and-mortality-in-cirrhosis-patients
#20
Thomas Damgaard Sandahl, Sidsel Hyldgaard Støy, Tea Lund Laursen, Sidsel Rødgaard-Hansen, Holger Jon Møller, Søren Møller, Hendrik Vilstrup, Henning Grønbæk
BACKGROUND AND AIMS: Hepatic macrophages (Kupffer cells) are involved in the immunopathology of alcoholic liver disease (ALD). The mannose receptor (MR, CD206), expressed primarily by macrophages, mediates endocytosis, antigen presentation and T-cell activation. A soluble form, sMR, has recently been identified in humans. We aimed to study plasma sMR levels and its correlation with disease severity and survival in ALD patients. METHODS: We included 50 patients with alcoholic hepatitis (AH), 68 alcoholic cirrhosis (AC) patients (Child-Pugh A (23), B (24), C (21)), and 21 healthy controls (HC)...
2017: PloS One
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