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https://www.readbyqxmd.com/read/29691687/-characteristics-of-pharmacotherapy-in-older-patients-with-rheumatism
#1
REVIEW
H-J Lakomek, Christian Schulz
Due to medical advances and the availability of efficient immunosuppressive therapies, the life-expectancy of people suffering from inflammatory rheumatic diseases is continuously increasing. In Germany, geriatric patients (definition: age older than 70 years combined with geriatric multimorbidity) affected, e. g. by rheumatoid arthritis (RA) frequently receive corticosteroids and less often biologic disease-modifying antirheumatic drugs (bDMARDs) and conventional DMARDs (cDMARDs), which is justified by additionally existing comorbidities and polypharmacy...
April 24, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29690685/-current-status-of-diagnosis-and-treatment-of-community-acquired-pneumonia-in-shanghai-revealed-by-a-questionnaire-analysis
#2
J Liu, J Zhang, Q J Cheng, J F Xu, Z J Jie, Y Jiao, Y Huang, J M Qu
Objective: To understand the current status of diagnosis and treatment of community-acquired pneumonia (CAP) among doctors in various hospitals across Shanghai, for the purpose of promoting the 2016 clinical practice guidelines for adult CAP of China. Methods: A questionnaire was designed to address the common questions in CAP management. The responses were collected via WeChat and the data were analyzed. Results: A total of 1 254 valid questionnaires were received, 46.1% from tertiary , 26.4% from secondary and 27...
April 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29689043/-treatment-of-allergic-and-vasomotor-rhinitis-the-role-of-beclomethasone-dipropionate-and-hyaluronic-acid-with-high-molecular-weight
#3
Giorgio Ciprandi, Matteo Gelardi
Inflammatory rhinitis is a very common disorder. It includes allergic rhinitis (AR) and non-allergic rhinitis (NAR). Nasal inflammation is shared by both disorders. So, anti-inflammatory treatment is indicated for both. Beclomethasone dipropionate (BDP) is a corticosteroid that is long time available both as intranasal spray and aerosol solution. BDP is a corticosteroid with proved efficacy in the treatment of rhinitis, both as spray and aerosol. Safety issue has been satisfactory explored, thus BDP is usually safe and well tolerated...
April 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29689030/checkpoint-inhibitor-immune-therapy-systemic-indications-and-ophthalmic-side-effects
#4
Lauren A Dalvin, Carol L Shields, Marlana Orloff, Takami Sato, Jerry A Shields
PURPOSE: To review immune checkpoint inhibitor indications and ophthalmic side effects. METHODS: A literature review was performed using a PubMed search for publications between 1990 and 2017. RESULTS: Immune checkpoint inhibitors are designed to treat system malignancies by targeting one of three ligands, leading to T-cell activation for attack against malignant cells. These ligands (and targeted drug) include cytotoxic T-lymphocyte antigen-4 (CTLA-4, ipilimumab), programmed death protein 1 (PD-1, pembrolizumab, nivolumab), and programmed death ligand-1 (PD-L1, atezolizumab, avelumab, durvalumab)...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29688920/mixed-treatment-comparisons-for-nonsurgical-treatment-of-knee-osteoarthritis-a-network-meta-analysis
#5
David S Jevsevar, Peter B Shores, Kyle Mullen, Danielle M Schulte, Gregory A Brown, Deborah S Cummins
INTRODUCTION: Knee osteoarthritis (KOA) is a significant health problem with lifetime risk of development estimated to be 45%. Effective nonsurgical treatments are needed for the management of symptoms. METHODS: We designed a network meta-analysis to determine clinically relevant effectiveness of nonsteroidal anti-inflammatory drugs, acetaminophen, intra-articular (IA) corticosteroids, IA platelet-rich plasma, and IA hyaluronic acid compared with each other as well as with oral and IA placebos...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29688503/the-potential-benefits-of-aspirin-for-primary-cardiovascular-prevention-in-rheumatoid-arthritis-a-secondary-analysis-of-the-precision-trial
#6
Daniel H Solomon, Peter Libby, Neville D Yeomans, Qiuqing Wang, Kathy E Wolski, Steven E Nissen, M Elaine Husni
Objective: Guidelines exist for the use of low-dose aspirin in the general population for primary cardiovascular (CV) prevention, but the risk-benefit considerations may differ in RA. While RA confers an increased CV risk, such patients more likely use NSAIDs and corticosteroids. Methods: We conducted a cohort study to assess potential risks and benefits of low-dose aspirin. We estimated incidence rates and hazard ratios (HRs) using Cox regression among subjects with RA but no known CV disease in the Prospective Randomized Evaluation of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen trial...
April 20, 2018: Rheumatology
https://www.readbyqxmd.com/read/29688172/comparative-effect-of-beclomethasone-dipropionate-and-cetirizine-on-acoustic-rhinometry-parameters-in-children-with-perennial-allergic-rhinitis-a-randomized-controlled-trial
#7
V Malizia, S Fasola, G Ferrante, G Cilluffo, R Gagliardo, M Landi, L Montalbano, D Marchese, S La Grutta
BACKGROUND AND OBJECTIVE: The effect of intranasal corticosteroids and oral antihistamines on acoustic rhinometry parameters was not directly compared in previous studies. Objectives: The primary aim was to compare the effect of 21-day treatment with nasal beclomethasone dipropionate (nBDP) versus cetirizine (CTZ) on nasal patency measured by acoustic rhinometry in children with PAR. Comparing their effect on nasal cytology, symptom severity, sleep quality and quality of life was the secondary aim...
April 24, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29688092/predictors-of-future-exacerbations-in-a-multi-ethnic-asian-population-with-asthma
#8
Tunn Ren Tay, Hang Siang Wong, Augustine Tee
OBJECTIVE: Exacerbations are important outcomes in asthma. Risk factors for exacerbations may differ in different populations. Although various demographic and clinical variables were examined in previous studies on exacerbation risks in asthma, important variables such as ethnicity, adherence, and medication titration were not included. This study examined independent predictors of future exacerbations in a multi-ethnic asthma population in Asia, while including the variables of ethnicity, medication adherence, and medication change in our analysis...
April 24, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29688072/steroid-free-immunosuppression-with-low-dose-tacrolimus-is-safe-and-significantly-reduces-the-incidence-of-new-onset-diabetes-mellitus-following-liver-transplantation
#9
M Castedal, C Skoglund, C Axelson, W Bennet
OBJECTIVES: Corticosteroids (CS) are traditionally used as part of the basal immunosuppression (IS) following liver transplantation (LT) but are known to be associated with an increased risk of new-onset diabetes mellitus (NODM), cardiovascular morbidity and mortality. The aim of this study was to retrospectively compare the incidence of transient as well as persistent NODM, rejection rate and patient- and graft survival between patients receiving steroid-based and steroid-free maintenance IS...
April 24, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29687946/does-tubulitis-without-interstitial-inflammation-represent-borderline-acute-t-cell-mediated-rejection
#10
Brian J Nankivell, Chow H P'ng, Jeremy R Chapman
Tubulitis without interstitial inflammation (Banff i0), termed "isolated tubulitis" (ISO-T), has been controversially included within the Banff "borderline" category of acute T cell mediated rejection (TCMR). This single-centre, retrospective, observational study of 2055 consecutive biopsies from 775 recipients, determined the clinical significance of ISO-T. ISO-T prevalence was 19.1%, comprising mild tubulitis (i0t1) in 97.2%. Independent clinical predictors of tubulitis were HLA mismatch, prior TCMR and antibody-mediated rejection, pulse corticosteroids, and BKVAN (P=0...
April 24, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29687787/drug-induced-thrombotic-microangiopathy-with-certolizumab-pegol
#11
Mehmet Baysal, Elif Gülsüm Ümit, Fatih Sarıtaş, Nil Su Kodal, Ahmet Muzaffer Demir
BACKGROUND: Certolizumab pegol is used to treat ankylosing spondylitis (AS), chron disease, psoriatic arthritis and rheumatoid arthritis. In contrast to other monoclonal antibodies such as infliximab and adalimumab, certolizumab does not contain an Fc fraction and hence, does not induce complement activation. In this case, we are presenting a case with thrombotic microangiopathy (TMA) due to certolizumab pegol, with a touch of pathophysiological approach to TMA. CASE REPORT: A-39-year-old man with AS of ten years presented with fatigue...
April 24, 2018: Balkan Medical Journal
https://www.readbyqxmd.com/read/29686955/perceptions-and-practices-in-parents-of-saudi-children-with-asthma-a-cross-sectional-survey
#12
Amani Abu-Shaheen, Isamme AlFayyad, Abdullah Nofal, Mohamad Al-Tannir, May AlMadaney, Humariya Heena
OBJECTIVE: To acquire more precise data on perceptions and practices adopted by Saudi parents of asthmatic children regarding asthma and its management. METHODS: A cross-sectional study was conducted through 2015 on 292 parents of children (aged 3-15 years) with asthma visiting the outpatient clinics and the emergency departments (ED) of two tertiary care medical centers in Riyadh city, using a self-administered questionnaire. RESULTS: Out of 292 parents who participated in this study, 60...
February 21, 2018: Curēus
https://www.readbyqxmd.com/read/29686875/nivolumab-induced-sialadenitis
#13
Saeko Takahashi, Xu Chieko, Tetsuya Sakai, Shigemichi Hirose, Morio Nakamura
Nivolumab has been increasingly used for a range of malignancies, and a variety of immune-related adverse events (irAEs) have been reported with its use. Nivolumab-induced sialadenitis (inflammation of salivary glands) and xerostomia (dry mouth) have been reported to occur in 0.03% and 0.05% respectively, but there have been no case reports published about these side effects. Sialadenitis is not a life-threatening irAEs, but xerostomia can become irreversible if not recognized and treated as it can otherwise lower quality of life and result in susceptibility to infection...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29686794/risperidone-induced-angioedema-with-concurrent-eps-symptoms-a-case-report-and-review-of-literature
#14
Gursharan Singh Samra, Saumitra Kant, Robert Chow
Angioedema has recently been reported as a side effect associated with the antipsychotic risperidone. We report a case of dystonia with concurrent angioedema due to risperidone. A 40-year-old male with a history of schizophrenia was started on 3 mg of risperidone BID and developed perioral and periorbital edema along with increased muscle rigidity and hand tremor within 24 h of initial administration. His symptoms abated after cessation of risperidone and intravenous administration of corticosteroids and antihistamine...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29686577/majocchi-granuloma-presenting-as-a-verrucous-nodule-of-the-lip
#15
Ritu Swali, Elmira Ramos-Rojas, Stephen Tyring
We present a case of Majocchi granuloma, a deep folliculitis, on the lip of a healthy 41-year-old man. The patient was successfully treated with systemic and topical antifungal medications. Correct diagnosis of this rare condition is needed, since misdiagnosis as an inflammatory dermatitis and treatment using topical corticosteroids can lead to dissemination of the infection.
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29685738/-idiopathic-orbital-inflammatory-syndrome-report-of-24-cases
#16
S Khochtali, M Zayani, I Ksiaa, I Ben Meriem, S Zaouali, B Jelliti, M Khairallah
BACKGROUND: Idiopathic orbital inflammatory syndrome (IOIS) is an inflammatory condition of unknown etiology. The inflammation may affect all the structures within the orbit (anterior, diffuse, apical, myositic, dacryoadenitis) and corresponds to uniquely orbital inflammation without an identifiable local cause or systemic disease. The goal of this study is to describe the clinical and radiographic characteristics of IOIS and discuss the role of orbital biopsy in this condition. PATIENTS AND METHODS: This is a retrospective review of the charts of 24 patients diagnosed with IOIS at Fattouma Bourguiba hospital, Monastir, Tunisia, from January 2007 to December 2015...
April 20, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29685567/minimally-invasive-treatment-of-ankle-fractures-in-patients-at-high-risk-of-soft-tissue-wound-healing-complications
#17
REVIEW
Sherif Mohamed Abdelgaid, Ahmed Fawaz Moursy, Eyad Abd Allah Elgebaly, Aly Mohamed Aboelenien
The complex nature of ankle fractures is magnified when seen in patients at high risk of soft tissue wound healing complications. The major categories include associated soft tissue injury, diabetes, tobacco use, peripheral vascular disease, malnutrition, alcoholism, and corticosteroid use. Because of the potential for wound dehiscence and infection with open reduction and internal fixation of ankle fractures in these patients, minimally invasive procedures have been described. The aims of the present study were to assess the possibility for, and evaluate the results and complications of, minimally invasive techniques for different types of malleolar fractures in high-risk patients...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29685453/bone-and-glucocorticoids
#18
Karine Briot
Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the most frequent cause of osteoporosis in young people. Bone loss and fracture risk increase rapidly after the initiation of corticosteroid therapy and are proportional to dose and treatment duration. The increase in fracture risk is not fully assessed by bone mineral density measurement, as it is also related to impaired bone quality and increased risk of falls. Prevention should be considered in all patients beginning corticosteroid therapy, especially as the underlying inflammation in itself impairs bone quality...
April 20, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29684622/injectable-drug-depot-engineered-to-release-multiple-ophthalmic-therapeutic-agents-with-precise-time-profiles-for-postoperative-treatment-following-ocular-surgery
#19
Maziar Mohammadi, Kisha Patel, Seyedeh P Alaie, Ron B Shmueli, Cagri G Besirli, Ronald G Larson, Jordan J Green
A multi-drug delivery platform is developed to address current shortcomings of post-operative ocular drug delivery. The sustained biodegradable drug release system is composed of biodegradable polymeric microparticles (MPs) incorporated into a bulk biodegradable hydrogel made from triblock copolymers with poly(ethylene glycol) (PEG) center blocks and hydrophobic biodegradable polyester blocks such as poly(lactide-co-glycolide) (PLGA), Poly(lactic acid) (PLA), or Poly(lactide-co-caprolactone) (PLCL) blocks. This system is engineered to flow as a liquid solution at room temperature for facile injection into the eye and then quickly gel as it warms to physiological body temperatures (approximately 37 °C)...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684579/age-and-gender-associations-with-systemic-corticosteroid-induced-morbidity-in-asthma
#20
Luke E Barry, Ciaran O'Neill, Chris Patterson, Joan Sweeney, David Price, Liam G Heaney
BACKGROUND: Treatment of severe asthma may include high dose systemic-corticosteroid therapy which is associated with substantial comorbidity. There is evidence to suggest that this burden is not evenly distributed across age, gender and corticosteroid exposure levels. OBJECTIVE: Examine the associations between age, gender, comorbidity, and patterns of healthcare cost across groups differentiated by corticosteroid exposure. METHODS: Patients with severe asthma (n=808) were matched by age and gender to patients with mild/moderate asthma (n=3,975) and non-asthma control subjects (n=2,412) from the Optimum Patient Care Research Database (OPCRD)...
April 20, 2018: Journal of Allergy and Clinical Immunology in Practice
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