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JOURNAL ARTICLE
Takato Yamasaki, Stephen P Sanders, Robyn J Hylind, Caitlin Milligan, Francis Fynn-Thompson, John E Mayer, Elizabeth D Blume, Kevin P Daly, Chrystalle Katte Carreon
BACKGROUND: As more pediatric patients become candidates for heart transplantation (HT), understanding pathological predictors of outcome and the accuracy of the pretransplantation evaluation are important to optimize utilization of scarce donor organs and improve outcomes. The authors aimed to investigate explanted heart specimens to identify pathologic predictors that may affect cardiac allograft survival after HT. METHODS: Explanted pediatric hearts obtained over an 11-year period were analyzed to understand the patient demographics, indications for transplant, and the clinical-pathological factors...
June 2024: Pediatric Transplantation
#2
JOURNAL ARTICLE
Nancy Elena Guzmán-Delgado, Claudia Elizabeth Velázquez-Sotelo, María José Fernández-Gómez, Luis Gerardo González-Barrera, Arturo Muñiz-García, Víctor Manuel Sánchez-Sotelo, Pilar Carranza-Rosales, Arnold Hernández-Juárez, Javier Morán-Martínez, Victoria Martínez-Gaytan
BACKGROUND AND OBJECTIVES: cardiovascular changes during pregnancy carry greater risk in heart disease. We analyze cardiovascular, obstetric and perinatal adverse effects associated with congenital and acquired heart disease during pregnancy and postpartum. MATERIALS AND METHODS: Cross-sectional and retrospective study, which included the 2017-2023 registry of pregnant or postpartum patients hospitalized with diagnosis of congenital or acquired heart disease. Adverse events (heart failure, stroke, acute pulmonary edema, maternal death, obstetric hemorrhage, prematurity and perinatal death) were compared with the clinical variables and the implemented treatment...
April 30, 2024: Revista Clínica Espanõla
#3
JOURNAL ARTICLE
Francesco Milo, Giulio Calcagni, Stella Maiolo, Fabrizio Drago, Stefano Vicari, Teresa Grimaldi Capitello, Deny Menghini, Angela Rossi
Advancements in early diagnosis and paediatric cardiac surgery have improved the long-term survival of patients with congenital heart disease, necessitating a thorough assessment of their health-related quality of life (HRQoL). This study aimed to assess HRQoL in paediatric patients with coarctation of the aorta (CoA) (both as reported by patients and caregivers), and to evaluate associated factors. Patients aged 5-18 years diagnosed with CoA and their parents were enrolled at Bambino Gesù Children's Hospital between September 2016 and December 2017...
May 2, 2024: Psychology, Health & Medicine
#4
JOURNAL ARTICLE
V V Suvorov, V V Zaitsev, E M Gvozd
BACKGROUND: Sternal infection is one of the most challenging complications to manage after heart surgery. The aim of our study is to evaluate the effectiveness of a developed algorithm for preventing sternal infection in pediatric patients after surgery for congenital heart disease (CHD). METHODS: We conducted a single-center study examining the treatment of 478 children with CHD. Patients were divided into 2 groups, taking into account the application of a developed management algorithm...
May 15, 2024: Heliyon
#5
Giancarlo Trimarchi, Concetta Zito, Giuseppe Pelaggi, Scipione Carerj, Gianluca Di Bella
BACKGROUND: Pericardial agenesis is a rare congenital heart disease characterized by a variable clinical presentation. CASE SUMMARY: A 32-year-old man was sent by an occupational health physician to our health care centre because of pathological electrocardiogram (ECG). On transthoracic echocardiogram, we had some difficulty to obtain a good quality of four-chamber apical view that was shifted upper and laterally towards the left anterior axillary line. Nonetheless, an abnormal diastolic expansion of the apex of the left ventricle (LV) that had an otherwise normal systolic function was detected...
April 2024: European Heart Journal. Case Reports
#6
Nigel E Drury, Carin van Doorn, Rebecca L Woolley, Rebecca J Amos-Hirst, Rehana Bi, Collette M Spencer, Kevin P Morris, James Montgomerie, John Stickley, Adrian Crucean, Alicia Gill, Matt Hill, Ralf J M Weber, Lukas Najdekr, Andris Jankevics, Andrew D Southam, Gavin R Lloyd, Osama Jaber, Imre Kassai, Giuseppe Pelella, Natasha E Khan, Phil Botha, David J Barron, Melanie Madhani, Warwick B Dunn, Natalie J Ives, Paulus Kirchhof, Timothy J Jones
OBJECTIVE: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis. METHODS: We performed a prospective, double-blind, randomized controlled trial at 2 centers in the United Kingdom. Children aged 3 to 36 months undergoing tetralogy of Fallot repair or ventricular septal defect closure were randomized 1:1 to receive bilateral preconditioning or sham intervention...
April 2024: JTCVS open
#7
JOURNAL ARTICLE
Veronica Lorenz, Stefano Mastrobuoni, Gaby Aphram, Matteo Pettinari, Laurent De Kerchove, Gebrine El Khoury
OBJECTIVES: The progressive increase in the use of implantable electronic devices, vascular access for dialysis and the increased life expectancy of patients with congenital heart diseases has led in recent years to a considerable number of right-side infective endocarditis, especially of the tricuspid valve. Although current guidelines recommend tricuspid valve repair for native tricuspid valve endocarditis, the percentage of valve replacements remains very high in numerous studies. The aim of our study is to analyze our experience in the treatment of tricuspid valve endocarditis with a reparative approach...
April 30, 2024: Interdiscip Cardiovasc Thorac Surg
#8
JOURNAL ARTICLE
Mahdi S Agha, Peter R Ermis, Wayne J Franklin, Dhaval R Parekh, Angeline D Opina, Jeffrey J Kim, Christina Y Miyake, Santiago O Valdes, Wilson W Lam
BACKGROUND: Atrial tachyarrhythmias are common and difficult to treat in adults with congenital heart disease. Dronedarone has proven effective in patients without congenital heart disease, but data are limited about its use in adults with congenital heart disease of moderate to great complexity. METHODS: A single-center, retrospective chart review of 21 adults with congenital heart disease of moderate to great complexity who were treated with dronedarone for atrial tachyarrhythmias was performed...
April 30, 2024: Texas Heart Institute Journal
#9
REVIEW
Sana Ashiq, Syed Najam Hyder, Kanwal Ashiq, Muhammad Farooq Sabar
BACKGROUND: Several studies have investigated the role of vascular endothelial growth factor (VEGF) variants, serum levels, and correlations with other extrinsic factors in congenital heart defects (CHDs); however, the findings need confirmation. The present systematic review evaluates the association between CHDs and genetic polymorphisms and serum expressions. METHODS: Relevant literature was searched through electronic databases using keywords and MeSH terms...
October 2023: Journal of Tehran Heart Center
#10
JOURNAL ARTICLE
Nour Rahnama, Nour Ben Jemâa, Arthur Colson, Agnès Pasquet, Laura Houard de Castro, Frédéric Debiève, Sophie Pierard
BACKGROUND: Advances in managing adult congenital heart disease (ACHD) have led to an increased number of women with CHD reaching childbearing age. This demographic shift underscores the need for improved understanding and prediction of complications during pregnancy in this specific ACHD population. Despite progress in maternal cardiac risk assessment, the prediction of neonatal outcomes for ACHD pregnancies remains underdeveloped. Therefore, the aims of this study are (1) to assess neonatal outcomes in a CHD women population, (2) to identify their predictive factors and (3) to propose a new risk score for predicting neonatal complications...
April 26, 2024: American Heart Journal
#11
JOURNAL ARTICLE
Peter Pastuszko, Michael G Katz, TaliaKate Ebel, Vitold Bozek, Leszek Kubin, Joanna Kubin
The mortality rate of newborns with severe congenital heart disease (CHD) has significantly decreased over the past few decades. However, many of these children experience neurological impairments, particularly following a hypoxic cardiac arrest. The use of extracorporeal membrane oxygenation (ECMO) has been considered an effective treatment for severe hypoxia in CHD cases. Various clinical studies have examined the use of ECMO for resuscitation after hypoxic cardiac arrest, but the results have been contradictory, showing a significant incidence of both mortality and morbidity in some studies while others report good outcome...
2024: Methods in Molecular Biology
#12
MULTICENTER STUDY
Linda Rossini, Silvia Ricci, Davide Montin, Chiara Azzari, Eleonora Gambineri, Marco Tellini, Francesca Conti, Andrea Pession, Francesco Saettini, Samuele Naviglio, Erica Valencic, Andrea Magnolato, Lucia Baselli, Sara Azzolini, Rita Consolini, Lucia Leonardi, Irene D'Alba, Elisa Carraro, Roberta Romano, Daniela Melis, Stefano Stagi, Emilia Cirillo, Giuliana Giardino, Alessandra Biffi, Claudio Pignata, Maria Caterina Putti, Antonio Marzollo
Kabuki Syndrome (KS) is a multisystemic genetic disorder. A portion of patients has immunological manifestations characterized by increased susceptibility to infections and autoimmunity. Aiming to describe the clinical and laboratory immunological aspects of KS, we conducted a retrospective multicenter observational study on patients with KS treated in centers affiliated to the Italian Primary Immunodeficiency Network.Thirty-nine patients were enrolled, with a median age at evaluation of 10 years (range: 3 m-21y)...
April 27, 2024: Journal of Clinical Immunology
#13
REVIEW
William A Schiavone, David S Majdalany
Congenital heart disease in adult patients (ACHD) includes individuals with native anatomic deformities and those who have benefited from corrective, ameliorative, or interventional heart and vascular interventions. Congenital heart disease is the most common birth defect, although with interventions most survive into adulthood. Newborns and children with complex congenital heart diseases that feature cyanosis fail to thrive, and once this is identified, heart failure can promptly undergo diagnostic evaluations and treatment...
April 9, 2024: Journal of Personalized Medicine
#14
REVIEW
William A Schiavone, David S Majdalany
The electrocardiogram is the first test that is undertaken when evaluating a patient's heart. Diagnosing congenital heart disease in an adult (ACHD) can be facilitated by knowing the classical electrocardiographic (EKG) findings. These EKG findings often result from the congenital defect that prevents a part of the cardiac conduction system from occupying its normal anatomic position. When these classical EKG findings are not present, the clinician should consider alternate diagnoses. As the patient with congenital heart disease ages, with native anatomy or after surgical or device repair, the EKG can be used to assess the patient's status and to decide if and when treatment requires adjustment...
March 29, 2024: Journal of Personalized Medicine
#15
COMPARATIVE STUDY
Shuo Yang, Sukun Lu, Yinghui Guo, Wenjun Luan, Jianhua Liu, Le Wang
OBJECTIVES: The increasing prevalence of severe Mycoplasma pneumoniae pneumonia (SMPP) poses a significant threat to the health of children. This study aimed to characterise and assess the outcomes in children with SMPP. METHODS: We retrospectively analysed children hospitalised for M. pneumoniae pneumonia (MPP) between January and December 2022. Retrospectively, demographic, clinical, underlying diseases, laboratory and radiological findings, and treatment outcomes were collected and analysed...
April 26, 2024: BMC Infectious Diseases
#16
JOURNAL ARTICLE
Candido Muñoz Muñoz, Filipa Farinha, Thomas McDonnell, Hajar Jbari, Hanh Nguyen, David Isenberg, Anisur Rahman, David Williams, Jaume Alijotas-Reig, Ian Giles
BACKGROUND: Females diagnosed with systemic lupus erythematosus (SLE) face an elevated risk of adverse pregnancy outcomes (APOs). However, the evidence regarding whether a similar association exists in patients with undifferentiated connective tissue disease (UCTD) is inconclusive. METHODS: We conducted a retrospective review (2006-2019) of pregnancy outcomes among patients with SLE (n = 51) and UCTD (n = 20) within our institution. We examined the occurrence of various APOs, encompassing miscarriage, stillbirth, termination, preterm birth, pre-eclampsia, eclampsia, HELLP syndrome, intrauterine growth restriction, abruption placentae, congenital heart block, or other cardiac abnormalities...
April 24, 2024: Revista Clínica Espanõla
#17
REVIEW
Giuseppe Antonio Mazza, Lilia Oreto, Giulia Tuo, Domenico Sirico, Sara Moscatelli, Giovanni Meliota, Antonio Micari, Paolo Guccione, Gabriele Rinelli, Silvia Favilli
A heart with a borderline ventricle refers to a situation where there is uncertainty about whether the left or right underdeveloped ventricle can effectively support the systemic or pulmonary circulation with appropriate filling pressures and sufficient physiological reserve. Pediatric cardiologists often deal with congenital heart diseases (CHDs) associated with various degrees of hypoplasia of the left or right ventricles. To date, no specific guidelines exist, and surgical management may be extremely variable in different centers and sometimes even in the same center at different times...
April 16, 2024: Diagnostics
#18
JOURNAL ARTICLE
Alexandra De Silvestro, Bettina Reich, Sarah Bless, Julika Sieker, Willemijn Hollander, Karen de Bijl-Marcus, Cornelia Hagmann, Joppe Nijman, Walter Knirsch
BACKGROUND: The treatment of preterm and low birth weight (LBW) neonates born with congenital heart disease (CHD) requiring early cardiac intervention remains challenging. We aimed to analyze morbidity and mortality in this combined high-risk patient group. METHODS: A retrospective cohort study was conducted of preterm [<37 weeks gestational age (GA)] and/or LBW neonates (<2,500 g) born with a diagnosis of CHD, which requires invasive cardiac intervention (surgery or catheter) within their first year of life...
2024: Frontiers in Pediatrics
#19
JOURNAL ARTICLE
Courtney M Strohacker, Noah S Cutler, Sunkyung Yu, Ray E Lowery, Caren S Goldberg
Necrotizing enterocolitis (NEC) increases morbidity and mortality for infants with single ventricle heart disease (SVHD). While hematochezia often proceeds NEC not all hematochezia progresses to NEC. We aimed to examine the incidence, risk-factors, and outcomes associated with hematochezia and NEC for infants with SVHD. A single-center cohort study including SVHD patients requiring Stage I palliation from 12/2010 to 12/2015 was performed. Demographic, clinical, and outcome measures during the interstage period were abstracted from medical records...
April 25, 2024: Pediatric Cardiology
#20
MULTICENTER STUDY
Laura Andreoli, Maria Chiara Gerardi, Maria Gerosa, Davide Rozza, Francesca Crisafulli, Roberta Erra, Daniele Lini, Laura Trespidi, Melissa Padovan, Francesca Ruffilli, Francesca Serale, Giovanna Cuomo, Bernd Raffeiner, Paolo Semeraro, Chiara Tani, Maria Sole Chimenti, Paola Conigliaro, Ariela Hoxha, Cecilia Nalli, Micaela Fredi, Maria Grazia Lazzaroni, Matteo Filippini, Marco Taglietti, Franco Franceschini, Sonia Zatti, Chiara Loardi, Rossana Orabona, Francesca Ramazzotto, Cristina Zanardini, Giulia Fontana, Giorgia Gozzoli, Claudia Barison, Paola Bizioli, Roberto Felice Caporali, Giulia Carrea, Manuela Wally Ossola, Beatrice Maranini, Ettore Silvagni, Marcello Govoni, Danila Morano, Rosita Verteramo, Andrea Doria, Teresa Del Ross, Maria Favaro, Antonia Calligaro, Marta Tonello, Maddalena Larosa, Margherita Zen, Alessandra Zambon, Marta Mosca, Dina Zucchi, Elena Elefante, Sabrina Gori, Florenzo Iannone, Maria Grazia Anelli, Marlea Lavista, Anna Abbruzzese, Carlo Giuseppe Fasano, Salvatore D'Angelo, Maria Stefania Cutro, Valentina Picerno, Teresa Carbone, Angela Anna Padula, Patrizia Rovere-Querini, Valentina Canti, Rebecca De Lorenzo, Ludovica Cavallo, Véronique Ramoni, Carlomaurizio Montecucco, Veronica Codullo, Alessandra Milanesi, Giulia Pazzola, Giuseppina Comitini, Chiara Marvisi, Carlo Salvarani, Oscar Massimiliano Epis, Sara Benedetti, Giuseppina Di Raimondo, Clizia Gagliardi, Claudia Lomater, Gloria Crepaldi, Elisa Bellis, Francesca Bellisai, Estrella Garcia Gonzalez, Anna Paola Pata, Martina Zerbinati, Maria Letizia Urban, Irene Mattioli, Annamaria Iuliano, Giandomenico Sebastiani, Antonio Luca Brucato, Emanuele Bizzi, Maurizio Cutolo, Leonardo Santo, Sara Tonetta, Gianpiero Landolfi, Greta Carrara, Alessandra Bortoluzzi, Carlo Alberto Scirè, Angela Tincani
OBJECTIVES: To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. METHODS: Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. RESULTS: We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19...
April 24, 2024: RMD Open
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