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Joint manipulation

Hamid Reza Mirzaei, Hossein Pourghadamyari, Majid Rahmati, Abbas Mohammadi, Javid Sadri Nahand, Abbas Rezaei, Hamed Mirzaei, Jamshid Hadjati
Recently clinical trials utilizing genetically engineered T cells expressing a chimeric antigen receptor (CAR) that is half monoclonal antibody and half T-cell receptor have demonstrated remarkable response in patients with advanced cancers like relapsed or refractory acute lymphoblastic leukemia (ALL) and lymphoma. Moreover, emerging chimeric genome editing tools such as zinc-finger nucleases (ZNFs), transcription activator-like effector nucleases (TALENs) and clustered regulatory interspaced short palindromic repeat (CRISPR)/Cas composed of sequence-specific DNA binding module(s) linked to a non-specific DNA cleavage domain have made possible to dramatically expand the ability to manipulate cells aim to treat and/or study a wide range of diseases including cancer...
March 12, 2018: Cancer Letters
Tao Jiang, Lin Jiang, Jun-de Shi, Yong-Ge Jiang, Du-Liang Liu
OBJECTIVE: To explore the treatment skill and clinical effect of bone setting manipulation in treating proximal humeral fracture with shoulder dislocation. METHODS: From January 2015 to December 2015, 118 cases of proximal humeral fractures with shoulder joint dislocation were treated by bone setting reduction and fixation with adhesive tape or Kirschner wire after reduction, including 56 males and 62 females with an average age of 61 years old ranging from 48 to 88 years old...
February 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Jun Liu, Ping Zhen, Sheng-Hu Zhou, Qi Tian, Hui Chen, Wei Wang, Xiao-le He, Xu-Sheng Li
OBJECTIVE: To evaluate the manipulation technique and clinical outcome of Tri-Lock bone preservation stem for acetabular protrusion combined with shorten defect of femoral head and neck. METHODS: From January 2013 to December 2015, 10 patients(12 hips) with acetabular protrusion combined with shorten defect of femoral head and neck were treated with total hip arthroplasty(THA) including 5 males and 5 female with an average age of(51.6±3.0) years old ranging from 42...
February 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Matthew P Kelly, Heather A Prentice, Wei Wang, Brian H Fasig, Dhiren S Sheth, Elizabeth W Paxton
BACKGROUND: Previous studies evaluating reasons for 30-day readmissions following total joint arthroplasty (TJA) may underestimate hospital-based utilization of healthcare resources during a patient's episode-of-care. We sought to identify common reasons for 90-day emergency department (ED) visits and hospital readmissions following primary elective unilateral TJA. METHODS: Patients from July 1, 2012 through June 30, 2015 having primary elective TJA and at least one 90-day postoperative ED-only visit and/or readmission for any reason were identified using the Kaiser Permanente Total Joint Replacement Registry...
February 12, 2018: Journal of Arthroplasty
Alexia Roux-Sibilon, Solène Kalénine, Cédric Pichat, Carole Peyrin
Visual extinction, a parietal syndrome in which patients exhibit perceptual impairments when two objects are simultaneously presented in the visual field, is reduced when objects are correctly positioned for action, indicating that action helps patients' visual attention. Similarly, healthy individuals make faster action decisions on object pairs that appear in left/right standard co-location for actions in comparison to object pairs that appear in a mirror location, a phenomenon called the paired-object affordance effect...
March 6, 2018: Neuropsychologia
Xuexin Xu, Yinghua Zhang, Jinpeng Li, Meng Zhang, Xiaonan Zhou, Shunli Zhou, Zhimin Wang
Improving winter wheat grain yield and water use efficiency (WUE) with minimum irrigation is very important for ensuring agricultural and ecological sustainability in the Northern China Plain (NCP). A three-year field experiment was conducted to determine how single irrigation can improve grain yield and WUE by manipulating the "sink-source" relationships. To achieve this, no-irrigation after sowing (W0) as a control, and five single irrigation treatments after sowing (75 mm of each irrigation) were established...
2018: PloS One
Daniel Vivas, Marta Caminal, Irene Oliver-Vila, Joaquim Vives
In the field of orthopedics, translational research of novel therapeutic approaches involves the use of large animal models (such as sheep, goat, pig, dog, and horse) due to the similarities with humans in weight, size, joint structure, and bone/cartilage healing mechanisms. Particularly in the development of cell-based therapies, the lack of manageable immunocompromised preclinical large animal models prevents the use of human cells, which makes it necessary to produce equivalent homologous cell types for the study of their pharmacodynamics, pharmacokinetics, and toxicology...
February 28, 2018: Current Protocols in Stem Cell Biology
Dennis Landin, Melissa Thompson, Meghan Jackson
The triceps brachii (TB) is the only muscle that lies along the posterior humerus, and its role in elbow extension has been the topic of investigation for many decades. The TB research has also included subjects such as strength training, effects of aging, training adaptions, etc. The purpose of this paper was to review some of the more unique investigations regarding the functions of the human TB. Specifically, this paper discusses articles that have explored the actions of the TB when manipulating the angles of the joints it crosses, the elbow and shoulder...
April 2018: Journal of Clinical Medicine Research
Eric C Stiefel, Louis McIntyre
Normal knee range of motion varies slightly between individuals and measures approximately 0° to -5° of extension to 140° of flexion. A full arc of motion is required for normal gait and knee function. Loss of normal joint range of motion may occur after a traumatic knee injury and may contribute to increased pain, lower functional outcome scores, and decreased patient satisfaction. Although multiple factors may contribute to the development of motion loss, the occurrence of intra-articular scar tissue adhesions, or post-traumatic arthrofibrosis, may limit the patient's knee motion in the early postoperative period...
August 2017: Arthroscopy Techniques
B Tarr, M Slater, E Cohen
Synchronising movements in time with others can have significant positive effects on affiliative attitudes and behaviors. To explore the generalizability of synchrony effects, and to eliminate confounds of suggestion, competence and shared intention typical of standard laboratory and field experiments, we used an Immersive Virtual Reality (VR) environment. Participants, represented as virtual humans, took part in a joint movement activity with two other programmed virtual humans. The timings of the co-participant characters' movements were covertly manipulated to achieve synchrony or non-synchrony with the focal participant...
February 27, 2018: Scientific Reports
Michela Balconi, Laura Gatti, Maria Elide Vanutelli
Introduction: The neural activity in response to ineffective joint actions was explored in the present study. Subjects involved in a cooperative but frustrating task (poor performance as manipulated by an external feedback) were required to cooperate (T1) during an attentional task in a way to synchronize their responses and obtain better outcomes. Methods: We manipulated their strategies by providing false feedbacks (T2) signaling the incapacity to create a synergy, which was reinforced by a general negative evaluation halfway through the game...
February 2018: Brain and Behavior
Yusuke Yamani, Jason S McCarley
Objective An experiment used workload capacity analysis to quantify automation usage strategy across different task difficulty and display format types in a speeded task. Background Workload capacity measures the efficiency of concurrent information processing and can serve as a gauge of automation usage strategy in speeded decision tasks. The present study used workload capacity analysis to investigate automation usage strategy while information display format and task difficulty were manipulated. Method Subjects performed a speeded judgment task assisted by an automated aid that issued decision cues at varying onset times...
February 1, 2018: Human Factors
Sergei Vlassov, Sven Oras, Mikk Antsov, Jelena Butikova, Rünno Lõhmus, Boris Polyakov
High surface energy of individual nanostructures leads to high adhesion and static friction that can completely hinder the operation of nanoscale systems with movable parts. For instance, silver or gold nanowires cannot be moved on silicon substrate without plastic deformation. In this paper we experimentally demonstrate the operational prototype of low-friction nano-joint. The movable part of the prototype is made either from gold or silver nano-pin produced by laser-induced partial melting of silver and gold nanowires resulting in formation of rounded bulbs on their ends...
February 22, 2018: Nanotechnology
Tom Ratz, Per T Smiseth
Parental care is highly variable, reflecting that parents make flexible decisions in response to variation in the cost of care to themselves and the benefit to their offspring. Much of the evidence that parents respond to such variation derives from handicapping and brood size manipulations, the separate effects of which are well understood. However, little is known about their joint effects. Here we fill this gap by conducting a joint handicapping and brood size manipulation in the burying beetle Nicrophorus vespilloides...
February 22, 2018: Journal of Evolutionary Biology
Alessandro Mirra, Micaël David Klopfenstein Bregger, Olivier Louis Levionnois
A 15-year-old Selle Francais gelding was presented to the equine referral hospital for treatment of a left guttural pouch mycosis previously diagnosed. After induction, the horse was shortly hoisted by all four feet, moved on a padded surgical table, and positioned in right lateral recumbency. In order to reduce the risk of bleeding during surgical manipulation of the carotid and maxillary arteries, a mean arterial pressure between 60 and 70 mmHg was targeted. After surgery, the horse was moved in a padded recovery box keeping the same lateral recumbency...
2018: Frontiers in Veterinary Science
Andrew S Harwich
Objective: The objective of this study was to describe the initial stage of a generalized theory of high-velocity, low-amplitude thrust (HVLAT) techniques for joint manipulation. Methods: This study examined the movements described by authors from the fields of osteopathy, chiropractic, and physical therapy to produce joint cavitation in both the metacarpophalangeal (MCP) joint and the cervical spine apophysial joint. This study qualitatively compared the kinetics, the similarities, and the differences between MCP cavitation and cervical facet joint cavitation...
December 2017: Journal of Chiropractic Humanities
Ben R Hando, Daniel I Rhon, Robert E Boyles, Julie M Whitman, Jenny L English
Study Design: Case series study. Objectives: Although there have been no reported complications from translational manipulation under anesthesia (tMUA) for individuals with adhesive capsulitis (AC) there are no cases reporting surgical findings post tMUA. Also, there are no studies evaluating health care utilization following tMUA. The purpose of this study was to: (1) report clinical outcomes following tMUA, (2) describe relevant health care costs and utilization following tMUA, and (3) summarize findings from two cases receiving joint arthroscopy following tMUA...
December 2017: Journal of Manual & Manipulative Therapy
Hai-Qiao Wang, Gui-Rong Dong, Chun-Ling Bao, Zhi-Hua Jiao
OBJECTIVE: To investigate the immediate effect of scalp acupuncture on walking pattern, using three-dimensional gait analysis (3D-GA), among patients in the subacute stage of intracerebral haemorrhage (ICH). METHODS: A subset of 30 patients with subacute ICH participating in a recently published randomised controlled trial who were able to walk independently were assessed by 3D-GA before and immediately after scalp acupuncture treatment (treatment group) or no intervention (control group) and the results presented here as a secondary analysis...
February 12, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Marietta Armaka, Caroline Ospelt, Manolis Pasparakis, George Kollias
NFκB activation and regulated cell death are important in tissue homeostasis, inflammation and pathogenesis. Here we show the role of the p55TNFR-IKK2l-Ripk3 axis in the regulation of synovial fibroblast homeostasis and pathogenesis in TNF-mediated mouse models of arthritis. Mesenchymal-specific p55TNFR triggering is indispensable for arthritis in acute and chronic TNF-dependent models. IKK2 in joint mesenchymal cells is necessary for the development of cartilage destruction and bone erosion; however, in its absence synovitis still develops...
February 12, 2018: Nature Communications
Amandeep Kumar, Gaurav Varshney, Pankaj K Singh, Deepak Agrawal, Guru D Satyarthee, Poodipedi S Chandra, Shashank S Kale, Ashok K Mahapatra
BACKGROUND: Atlantoaxial spondyloptosis (AAS), which is defined as complete displacement of facets of atlas anterior to the facets of axis such that there is no contact between the 2 articulating surfaces, is an extremely rare manifestation of atlantoaxial instability. The reason for an extreme rarity of traumatic AAS is probably the severity of injury in traumatic AAS that is usually incompatible to life. It represents the most severe form of atlantoaxial dislocation, and complete reduction in such a case presents a real technical challenge because of the interlocking of C1-C2 facets...
February 2018: World Neurosurgery
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