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https://www.readbyqxmd.com/read/29426261/effect-of-blue-dye-guided-lymph-channel-ligation-on-the-surgical-morbidity-of-groin-lymphadenectomy-for-vulval-cancer-a-feasibility-study
#1
Rasiah Bharathan, Kavitha Madhuri, Andrew Fish, Peter Larsen-Disney, Jayanthan Chatterjee, Simon Butler-Manuel, Anil Tailor, Sean Kehoe
Inguinal lymphadenectomy has significant morbidity. Blue dye-guided lymph channel ligation is an effective technique for resolving lymphocele. This was a feasibility study in a preventative setting. Patients with vulval cancer requiring bilateral inguinal lymphadenectomy were recruited. After lymphadenectomy, patent blue V dye was injected and the severed lymph channels leaking blue dye, on the randomly-designated side were ligated. The median age was 72.5 years and the median body mass index was 25. The median lymph node harvest was 18...
February 9, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29414052/induction-of-reproductive-cell-death-in-caenorhabditis-elegans-across-entire-linear-energy-transfer-range-of-carbon-ion-irradiation
#2
Liangwen Chen, Huangqi Tang, Yan Du, Zhangyu Dai, Ting Wang, Lijun Wu, Libin Zhou, Po Bian
Heavy-ion radiation has attracted extensive attention as an effective cancer therapy because of the varying energy deposition along its track and its high cell-killing effect. Reproductive cell death (RCD), also known as clonogenic death, is an important mode of death of the cancer cells after radiotherapy. Although RCD induced by heavy-ion irradiation with various linear energy transfers has been demonstrated using clonogenic assay in vitro, little is known about the distribution of RCD across the range of heavy-ion irradiation at the level of whole organisms...
February 1, 2018: DNA Repair
https://www.readbyqxmd.com/read/29324539/trial-of-optimal-personalised-care-after-treatment-gynaecological-cancer-topcat-g-a-randomized-feasibility-trial
#3
Val Morrison, Llinos H Spencer, Nikki Totton, Kirstie Pye, Seow Tien Yeo, Caryl Butterworth, Liz Hall, Rhiannon Whitaker, Rhiannon Tudor Edwards, Laura J Timmis, Zoe Hoare, Richard D Neal, Clare Wilkinson, Simon Leeson
OBJECTIVE: This study aimed to evaluate the feasibility of completing a parallel-group randomized controlled trial to compare usual follow-up care for women who have completed treatment of gynecological cancer against a nurse-led telephone intervention, known as Optimal Personalised Care After Treatment-Gynaecological. METHODS: The unblinded trial aimed to recruit patients who had completed treatment of cervical, endometrial, epithelial ovarian, or vulval cancer within the previous 3 months at 3 North Wales hospitals...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29290193/spectrum-of-gynecological-malignancies-at-jamshoro
#4
Naheed Parveen, Raheel Sikander, Majida, Shaheen
OBJECTIVE: To describe the frequency and spectrum of different types of gynecological malignancies. STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences, Jamshoro, from January 2014 to December 2015. METHODOLOGY: All patients with gynecological malignancies, admitted at the study place, whether previously diagnosed or need to establish the diagnosis on the basis of EUA, biopsy, staging and for surgery during the study period were included...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29144546/presence-of-infection-and-analysis-of-hpv-subtypes-in-girls-younger-than-9-years-old-attended-at-a-referral-service-in-esp%C3%A3-rito-santo-brazil
#5
Mariana Penha De Nadai Sartori, Lidiane Pignaton Agostini, Thaís Tristão Tovar, Raquel Silva Dos Reis, Raquel Spinassé Dettogni, Eldamária de Vargas Wolfgramm Dos Santos, Antônio Chambô Filho, Iúri Drumond Louro
PURPOSE: Human papillomavirus is found in adults and adolescents and is associated with genital warts and cervical cancer. However, it has been detected in girls younger than 10 years old. Currently, there are no prevention methods for this age group, since it is not considered a risk group. The aim of this study was to evaluate the presence of infection and HPV subtype in girls under 9 years old attended at a referral service in the State of Espírito Santo, Brazil. METHODS: Forty-three girls younger than 9 years old had gynecological brush samples collected from vulval and perineal/anal regions...
November 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29017363/a-survey-on-the-use-of-topical-steroids-in-patients-treated-for-lichen-sclerosus-associated-vulval-squamous-cell-carcinoma
#6
Rachel Pounds, Sanna Tahir, Christopher Dawson, Ciaran Woodman, David Luesley, Jason Yap
Evidence suggests that lichen sclerosus (LS) is the primary aetiological factor for local vulval recurrence (LVR) in vulval squamous cell carcinoma (VSCC). The long-term application of topical corticosteroids is believed to prevent LVR. Patients treated for LS-associated VSCC at a gynaecological cancer centre were invited to complete a questionnaire to evaluate whether they are receiving corticosteroids. 55 of the 95 eligible patients (58%) completed the questionnaire; LS was treated in 69%, with steroids given to 84...
October 10, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28930804/venous-thromboembolism-in-gynecological-malignancy
#7
Abigail Cohen, Chung Sim Lim, Alun Huw Davies
OBJECTIVE: Venous thromboembolism (VTE) is a recognized complication of gynecological malignancy and represents a leading cause of morbidity and mortality in these patients. The review aimed to discuss the incidence, risk factors, and clinical presentation of VTE before examining the literature on the diagnosis, prevention, and management in the context of uterine, cervical, ovarian, and vulval cancers. METHODS/MATERIALS: A literature search was performed using Ovid Medline and Embase with the following words: "gynecological malignancy," "pelvic tumor," "venous thromboembolism," "deep vein thrombosis" and "pulmonary embolism...
November 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28826403/gastrointestinal-adenocarcinoma-metastasizing-to-the-vulva-a-case-report
#8
Muchabayiwa F Gidiri, M Nyakura, M Hukuimwe, T Magwali, R Makunike-Mutasa, F D Museta
BACKGROUND: Metastatic vulval adenocarcinoma is a rare occurrence with only a few cases reported to date. They can arise from the breast, gastrointestinal system, or endometrium. CASE PRESENTATION: We present the case of a 55-year-old Black African woman who presented with vulval itching which progressed to warty lesions. Histology revealed a vulval adenocarcinoma which immunohistochemistry suggested was of gastrointestinal origin. Colonoscopy later confirmed an anorectal tumor as the primary site...
August 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28814588/massive-epidermal-vulval-cyst-an-unusual-late-complication-of-female-genital-mutilation
#9
Tejinder Kaur-Desai, Argyrios Makris
Vulval epidermal cysts are rare and infrequently described in literature. They present a difficult diagnostic dilemma and surgical challenges. They most commonly occur as a late complication of female genital mutilation (FGM) and manifest as a primary condition. We present a case of a large vulval epidermal inclusion cyst, lined by vulval squamous epithelium, in a woman with a background of FGM who was referred with suspected vulval cancer. We discuss the clinical presentation, MRI findings, surgical treatment and outcome...
August 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28791633/c-elegans-vulva-induction-an-in-vivo-model-to-study-epidermal-growth-factor-receptor-signaling-and-trafficking
#10
Kimberley Gauthier, Christian E Rocheleau
Epidermal growth factor receptor (EGFR)-mediated activation of the canonical Ras/MAPK signaling cascade is responsible for cell proliferation and cell growth. This signaling pathway is frequently overactivated in epithelial cancers; therefore, studying regulation of this pathway is crucial not only for our fundamental understanding of cell biology but also for our ability to treat EGFR-related disease. Genetic model organisms such as Caenorhabditis elegans, a hermaphroditic nematode, played a vital role in identifying components of the EGFR/Ras/MAPK pathway and delineating their order of function, and continues to play a role in identifying novel regulators of the pathway...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28619365/aucklandia-lappa-dc-extract-enhances-gefitinib-efficacy-in-gefitinib-resistance-secondary-epidermal-growth-factor-receptor-mutations
#11
Guan Huang, Yanli Tong, Qidi He, Jie Wang, Zuanguang Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Aucklandia lappa DC. is a widely used medicinal plant in China, India and Pakistan for a long time. Previously, a number of different pharmacological experiments in vitro and in vivo have convincingly demonstrated the abilities of it to exhibit anticancer activities. Reynoutria japonica Houtt. has also been widely used as traditional Chinese medicinal plant. Previous studies have demonstrated that it is bioactive to exhibit anticancer activities. AIM OF THE STUDY: This study aims to investigate whether the extracts of Aucklandia lappa DC...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28609712/two-week-waits-what-are-we-waiting-for
#12
Ahmed R Abdelraheim, Mohammed Khairy, Mo'men Mohammed, Alexandra Lawrence
OBJECTIVES: To evaluate the two-week referral system by analysing the 2-week wait (2WW) referrals to the rapid access gynaecology clinic over one year. We have also sought to identify the risk factors for endometrial cancer to help setting criteria that can be used to prioritise urgent appointments, refine subsequent management strategies. STUDY DESIGN: Retrospective review of the data of all women referred for suspected gynaecological cancers over one year via the 2 WW office at Queen's Hospital, Romford, UK...
August 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28546667/adenoid-cystic-carcinoma-of-vulva-11%C3%A2-years-single-institution-experience
#13
Leena Rose Johnson, Rema Prabhakaran Nair, Suchetha Sambasivan, Rari P Mony, Jayapriya Gangadharan, Aswin Kumar, Iqbal M Ahamed
INTRODUCTION: Adenoid cystic carcinoma of vulva (ACC-vulva) is an extremely rare entity with <100 cases reported in the literature so far. OBJECTIVE: To study the clinical profile and outcome of ACC-vulva treated at a tertiary cancer care centre in South India. METHODS: This is a retrospective, record-based study of histopathologically confirmed cases of ACC-vulva treated at our centre from January 2005 to March 2016. RESULTS: Only four patients were diagnosed with ACC-vulva during the 11-year period under study...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28418164/molecular-subtyping-of-mammary-like-adenocarcinoma-of-the-vulva-shows-molecular-similarity-to-breast-carcinomas
#14
Basile Tessier-Cloutier, Karama Asleh-Aburaya, Varsha Shah, W Glenn McCluggage, Anna Tinker, C Blake Gilks
AIMS: Mammary-like adenocarcinoma (MLA) of the vulva is thought to be derived from vulvar mammary-like glands. The aim of this study was to characterize a series of MLAs by using an immunohistochemical algorithm that identifies the major molecular subtypes of breast cancer. METHODS AND RESULTS: Seven cases of vulval MLA were stained for oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki67, epidermal growth factor receptor (EGFR), cytokeratin (CK) 5, nestin, and inositol polyphosphate-4-phosphatase (INPP4b)...
April 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28381390/the-possible-role-of-the-da-vinci-robot-for-patients-with-vulval-carcinoma-undergoing-inguinal-lymph-node-dissection
#15
Christos Iavazzo, Paraskevi Evangelia Iavazzo, Ioannis D Gkegkes
Inguinal lymph node dissection represents the gold standard of treatment for patients with vulval carcinoma. The application of minimally invasive techniques, such as robotics, in the surgical treatment of gynecologic cancer, reduced the rate of postoperative complications, which has an important impact on the quality of patients' life. Robotic inguinal lymph node dissection is a safe and oncologically effective but expensive and time-consuming approach in patients with penile cancer or melanoma. However, it is related with less postoperative complications, especially less lymphocele or lymphedema rates, and can improve the patients' quality of life while minimizing cost for health systems...
June 1, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28127185/veil-surgical-steps
#16
REVIEW
S K Raghunath, H Nagaraja, N Srivatsa
Inguinal lymphadenectomy remains the standard of care for metastatic nodal disease in cases of penile, urethral, vulval and vaginal cancers. Outcomes, including cure rates and overall and progression-free survivals, have progressively improved in these diseases with extending criteria to offer inguinal lymph node dissection for patients 'at-risk' for metastasis or loco-regional recurrence. Hence, despite declining incidence of advanced stages of these cancers, many patients will still need to undergo lymphadenectomy for optimal oncological outcomes...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28061900/a-clitoral-verrucous-carcinoma-in-an-area-of-lichen-planus-has-aggressive-features
#17
Wiebren A A Tjalma, Vasiliki Siozopoulou, Manon T Huizing
BACKGROUND: Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer. CASE PRESENTATION: A 79-year-old woman consulted for vulval itching. On clinical examination, a 3-cm large verrucous clitoral cancer in an area of lichen planus was seen. Based on her last clinical examination, the growth was estimated to be 1 cm(2) per month with an invasion depth after 6 months of 5 mm...
January 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27965882/trial-of-optimal-personalised-care-after-treatment-for-gynaecological-cancer-topcat-g-a-study-protocol-for-a-randomised-feasibility-trial
#18
Kirstie Pye, Nicola Totton, Nicholas Stuart, Rhiannon Whitaker, Val Morrison, Rhiannon Tudor Edwards, Seow Tien Yeo, Laura J Timmis, Caryl Butterworth, Liz Hall, Tekendra Rai, Zoe Hoare, Richard D Neal, Clare Wilkinson, Simon Leeson
BACKGROUND: Gynaecological cancers are diagnosed in over 1000 women in Wales every year. We estimate that this is costing the National Health Service (NHS) in excess of £1 million per annum for routine follow-up appointments alone. Follow-up care is not evidence-based, and there are no definitive guidelines from The National Institute for Health and Care Excellence (NICE) for the type of follow-up that should be delivered. Standard care is to provide a regular medical review of the patient in a hospital-based outpatient clinic for a minimum of 5 years...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27830172/an-unusual-case-of-basal-cell-carcinoma-of-the-vulva-with-lung-metastases
#19
G A Watson, D Kelly, L Prior, E Stanley, O MacEneaney, T Walsh, C M Kelly
Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27465889/prognostic-factors-of-recurrence-and-survival-in-vulvar-melanoma-subgroup-analysis-of-the-vulvar-cancer-study
#20
Sara Iacoponi, Patricia Rubio, Enrique Garcia, Martin K Oehler, Javier Diez, Begoña Diaz-De la Noval, Pablo Mora, Barbara Gardella, Ivan Gomez, Ioannis C Kotsopoulos, Kamil Zalewski, Ignacio Zapardiel
OBJECTIVE: The aim of this study was to analyze the prognostic factors related to the recurrence rate and overall survival of vulval melanoma patients by means of a subgroup analysis of the VULvar CANcer study. METHODS: The international multicenter VULvar CANcer study involved 100 international centers, which contributed 2453 vulvar cancer cases. Of the 1727 patients finally included in the study, 42 were suffering from vulvar melanoma (2.4%). RESULTS: The mean follow-up for vulval melanoma patients was 44...
September 2016: International Journal of Gynecological Cancer
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