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https://www.readbyqxmd.com/read/28930878/performance-of-future-elite-players-at-the-nfl-scouting-combine
#1
David P Hedlund
The purpose of this study is to examine players' physical and performance measures taken at the NFL Scouting Combine and compare these to their future performance in the NFL. From 2002-2016, three types of player data (N=5,506) were collected from secondary data sources. Results players earned on various NFL Scouting Combine drills and measurements (e.g., height, weight, 40-yard dash time, vertical jump, bench press repetitions, shuttle run time, and 3-cone drill time), the position players play on the field (e...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930640/age-related-decline-in-endurance-running-performance-an-example-of-a-multiple-world-records-holder
#2
Romuald Lepers, Thomas Cattagni
This study examined the age-related decline in endurance running performance of one of the greatest master runners ever, Ed Whitlock. His running performances from 1500 m to marathon were analyzed for five periods of 5 years from 65-69 years to 85-89 years. Despite exceptional running performances for his advanced age, the rate of decline in his performances increased after 80 years and was drastically amplified after 85 years.
September 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28927638/quantitative-risk-assessment-via-uncertainty-analysis-in-combination-with-error-propagation-for-the-determination-of-the-dynamic-design-space-of-the-primary-drying-step-during-freeze-drying
#3
Pieter-Jan Van Bockstal, Séverine Thérèse F C Mortier, Jos Corver, Ingmar Nopens, Krist V Gernaey, Thomas De Beer
Traditional pharmaceutical freeze-drying is an inefficient batch process often applied to improve the stability of biopharmaceutical drug products. The freeze-drying process is regulated by the (dynamic) settings of the adaptable process parameters shelf temperature Ts and chamber pressure Pc. Mechanistic modelling of the primary drying step allows the computation of the optimal combination of Ts and Pc in function of the primary drying time. In this study, an uncertainty analysis was performed on the mechanistic primary drying model to construct the dynamic Design Space for the primary drying step of a freeze-drying process, allowing to quantitatively estimate and control the risk of cake collapse (i...
September 16, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28927094/genomic-markers-of-ovarian-adenocarcinoma-and-its-relevancy-to-the-effectiveness-of-chemotherapy
#4
Monika Englert-Golon, Bartosz Burchardt, Bartlomiej Budny, Szymon Dębicki, Blanka Majchrzycka, Elzbieta Wrotkowska, Piotr Jasiński, Katarzyna Ziemnicka, Radosław Słopień, Marek Ruchała, Stefan Sajdak
Ovarian cancer is the eighth most common cancer and the seventh highest cause of cancer-associated mortality in women worldwide. It is the second highest cause of mortality among female reproductive malignancies. The current standard first-line treatment for advanced ovarian cancer includes a combination of surgical debulking and standard systemic platinum-based chemotherapy with carboplatin and paclitaxel. Although a deeper understanding of this disease has been attained, relapse occurs in 70% of patients 18 months subsequent to the first-line treatment...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926802/patterns-of-trunk-muscle-activation-during-walking-and-pole-walking-using-statistical-non-parametric-mapping
#5
Luca Zoffoli, Massimiliano Ditroilo, Ario Federici, Francesco Lucertini
This study used surface electromyography (EMG) to investigate the regions and patterns of activity of the external oblique (EO), erector spinae longissimus (ES), multifidus (MU) and rectus abdominis (RA) muscles during walking (W) and pole walking (PW) performed at different speeds and grades. Eighteen healthy adults undertook W and PW on a motorized treadmill at 60% and 100% of their walk-to-run preferred transition speed at 0% and 7% treadmill grade. The Teager-Kaiser energy operator was employed to improve the muscle activity detection and statistical non-parametric mapping based on paired t-tests was used to highlight statistical differences in the EMG patterns corresponding to different trials...
September 9, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28926704/chromatographic-properties-of-minimal-aspect-ratio-monolithic-silica-columns
#6
Takeshi Hara, Shunta Futagami, Wim De Malsche, Sebastiaan Eeltink, Herman Terryn, Gino V Baron, Gert Desmet
We report on a study wherein we synthesized TMOS-based silica monolithic skeletons in capillaries with an i.d. of 5 and 10 μm to produce skeleton structures with very low capillary-to-domain size aspect-ratios. These structures include the absolute minimal aspect-ratio case of a monolithic structure whose cross-section only contains a single node point. With domain-sized based reduced plate heights running as low as hmin = 1.3-1.5 for retained coumarin dyes providing a retention factor of k = 0.6-1.0, the study confirms the classic observation that ultra-low aspect ratio columns generate a markedly lower dispersion than columns with a larger aspect ratio made in the past by Knox, Jorgenson and Kennedy for the packed bed of spheres, but now for silica monoliths...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926007/economics-for-assisting-policy-makers-to-take-decisions-about-new-and-endemic-diseases
#7
T E Carpenter
Animal health policy-makers are frequently faced with making decisions concerning the control and exclusion of diseases in livestock and wildlife populations. Economics is one of the tools they have to aid their decision-making. It can enable them to make objective decisions based on the expected costs and benefits of their policy. In addition, economics can help them determine both the distribution impact and the indirect impact of their decisions. However, economics is only one of many tools available to policy-makers, who also need to consider non-economic outcomes in their decision-making process...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925577/sex-and-maturity-status-affected-the-validity-of-a-submaximal-cycle-test-in-adolescents
#8
Frida Björkman, Andrea Eggers, Adam Stenman, Tony Bohman, Björn Ekblom, Örjan Ekblom
AIM: This study assessed the validity and reliability of the Ekblom-Bak (EB) submaximal cycle test in adolescents and identified any sex or maturity-related factors for prediction errors. METHODS: We recruited 50 healthy subjects through a public announcement in Stockholm, Sweden, in 2016. The 27 boys and 23 girls were aged 10-15 years and in Tanner stages I-IV. They performed an EB test and incremental treadmill running test for direct measurement of maximal oxygen uptake (VO2 max)...
September 19, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28925575/evaluation-of-neonatal-transport-in-a-european-country-shows-that-regional-provision-is-not-cost-effective-or-sustainable-and-needs-to-be-re-organised
#9
Carlo Bellini, Michela Pasquarella, Luca A Ramenghi, Daniela Ambrosino, Anna F Sciomachen
AIM: There are three dedicated and 41 on-call neonatal emergency transport services (NETS) in Italy and activity levels vary dramatically. We examined the cost-effectiveness of a hub-and-spoke NETS by looking at the costs and activity levels in the Liguria region and established the financial needs for improving NETS across Italy. METHODS: The cost of running NETS in the Liguria region from 2012-2015 was evaluated and analysed and three different models determined the transports needed each year to provide the best organisational model...
September 19, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28923308/effect-of-penile-traction-and-vacuum-erectile-device-for-peyronie-s-disease-in-an-animal-model
#10
Haocheng Lin, Chunhui Liu, Run Wang
BACKGROUND: Penile traction therapy with the use of a traction device (TD) or vacuum erectile device (VED) has been studied as local modalities for Peyronie's disease (PD). AIM: To identify changes of penile curvature, erectile function, and possible cellular and molecular mechanisms between the TD and VED in a rat model of PD. METHODS: Peyronie's plaque was induced in 30 adult male rats. Then, rats were randomly divided into control (PD without treatment), VED, and TD groups...
September 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28923139/cerebral-hemodynamics-and-executive-function-during-exercise-and-recovery-in-normobaric-hypoxia
#11
Jon Stavres, Hayden D Gerhart, Jung-Hyun Kim, Ellen L Glickman, Yongsuk Seo
BACKGROUND: Hypoxia and exercise each exhibit opposing effects on executive function, and the mechanisms for this are not entirely clear. This study examined the influence of cerebral oxygenation and perfusion on executive function during exercise and recovery in normobaric hypoxia (NH) and normoxia (N). METHODS: There were 18 subjects who completed cycling trials in NH (12.5% FIo2) and N (20.93% FIo2). Right prefrontal cortex (PFC) oxyhemoglobin (O2Hb) and middle cerebral artery blood velocity (MCAbv) were collected during executive function challenges [mathematical processing and running memory continuous performance task (RMCPT)] at baseline, following 30 min of acclimation, during 20 min of cycling (60% Vo2max), and at 1, 15, 30, and 45 min following exercise...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28922841/interactive-problem-solving-sessions-in-an-introductory-bioscience-course-engaged-students-and-gave-them-feedback-but-did-not-increase-their-exam-scores
#12
James P McEvoy
Active learning, including the promotion of student interactivity in lectures, has been found to improve student engagement and performance in university science classes. This letter describes the use of Pearson's Learning Catalytics to run regular, formatively assessed problem-solving sessions as part of the semiflipped redesign of an introductory level university bioscience course. Students found the problem-solving sessions more engaging than a traditional lecture, and felt that they were receiving better feedback on their progress in the course...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28922704/direct-acting-antivirals-for-chronic-hepatitis-c
#13
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs), e.g. sofosbuvir, are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). Sustained virological response (SVR) is used by investigators and regulatory agencies as a surrogate outcome for morbidity and mortality, based solely on observational evidence...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922682/the-energy-cost-of-running-with-the-ball-in-soccer
#14
Alessandro Piras, Milena Raffi, Charalampos Atmatzidis, Franco Merni, Rocco Di Michele
Running with the ball is a soccer-specific activity frequently used by players during match play and training drills. Nevertheless, the energy cost (EC) of on-grass running with the ball has not yet been determined. The purpose of this study was therefore to assess the EC of constant-speed running with the ball, and to compare it with the EC of normal running. Eight amateur soccer players performed two 6- min runs at 10 km/h on artificial turf, respectively with and without the ball. EC was measured with indirect calorimetry and, furthermore, estimated with a method based on players' accelerations measured with a GPS receiver...
September 18, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28922649/determination-of-74-new-psychoactive-substances-in-serum-using-automated-in-line-solid-phase-extraction-liquid-chromatography-tandem-mass-spectrometry
#15
Sabrina Lehmann, Tobias Kieliba, Justus Beike, Mario Thevis, Katja Mercer-Chalmers-Bender
A detailed description is given of the development and validation of a fully automated in-line solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) method capable of detecting 90 central-stimulating new psychoactive substances (NPS) and 5 conventional amphetamine-type stimulants (amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA), methamphetamine) in serum. The aim was to apply the validated method to forensic samples...
September 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28922645/spectrophotometric-determination-of-fluoxetine-by-molecularly-imprinted-polypyrrole-and-optimization-by-experimental-design-artificial-neural-network-and-genetic-algorithm
#16
Azizollah Nezhadali, Maryam Omidvar Motlagh, Samira Sadeghzadeh
A selective method based on molecularly imprinted polymer (MIP) solid-phase extraction (SPE) using UV-Vis spectrophotometry as a detection technique was developed for the determination of fluoxetine (FLU) in pharmaceutical and human serum samples. The MIPs were synthesized using pyrrole as a functional monomer in the presence of FLU as a template molecule. The factors that affecting the preparation and extraction ability of MIP such as amount of sorbent, initiator concentration, the amount of monomer to template ratio, uptake shaking rate, uptake time, washing buffer pH, take shaking rate, Taking time and polymerization time were considered for optimization...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28922121/motion-blur-kernel-estimation-via-deep-learning
#17
Xiangyu Xu, Jinshan Pan, Yu-Jin Zhang, Ming-Hsuan Yang
The success of the state-of-the-art deblurring methods mainly depends on restoration of sharp edges in a coarse-tofine kernel estimation process. In this paper, we propose to learn a deep convolutional neural network for extracting sharp edges from blurred images. Motivated by the success of the existing filtering based deblurring methods, the proposed model consists of two stages: suppressing extraneous details and enhancing sharp edges. We show that the two-stage model simplifies the learning process and effectively restores sharp edges...
September 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28922071/implementing-electronic-data-capture-at-a-well-established-health-and-demographic-surveillance-site-in-rural-northern-malawi
#18
Estelle McLean, Albert Dube, Jacky Saul, Keith Branson, Mabvuto Luhanga, Oddie Mwiba, Fredrick Kalobekamo, Steffen Geis, Amelia C Crampin
This article aims to assess multiple issues of resources, staffing, local opinion, data quality, cost, and security while transitioning to electronic data collection (EDC) at a long-running community research site in northern Malawi. Levels of missing and error fields, delay from data collection to availability, and average number of interviews per day were compared between EDC and paper in a complex, repeated annual household survey. Three focus groups with field and data staff with experience using both methods, and in-depth interviews with participants were carried out...
2017: Global Health Action
https://www.readbyqxmd.com/read/28921538/a-fast-inverse-treatment-planning-strategy-facilitating-optimized-catheter-selection-in-image-guided-high-dose-rate-interstitial-gynecologic-brachytherapy
#19
Christian V Guthier, Antonio L Damato, Juergen W Hesser, Akila N Viswanathan, Robert A Cormack
PURPOSE: Interstitial high-dose-rate (HDR) brachytherapy is an important therapeutic strategy for the treatment of locally advanced gynecologic (GYN) cancers. The outcome of this therapy is determined by the quality of dose distribution achieved. This paper focuses on a novel yet simple heuristic for catheter selection for GYN HDR brachytherapy and their comparison against state of the art optimization strategies. The proposed technique is intended to act as a decision-supporting tool to select a favorable needle configuration...
September 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28919497/body-mass-index-predicts-selected-physical-fitness-attributes-but-is-not-associated-with-performance-on-military-relevant-tasks-in-u-s-army-soldiers
#20
Joseph R Pierce, David W DeGroot, Tyson L Grier, Keith G Hauret, Bradley C Nindl, Whitfield B East, Michael S McGurk, Bruce H Jones
OBJECTIVES: Army body composition standards are based upon validated criteria; however, certain field-expedient methodologies (e.g., weight-for-height, body mass index [BMI]) may disqualify individuals from service who may otherwise excel on physical performance and military-relevant tasks. The purpose was to assess soldier physical performance and military-specific task/fitness performance stratified by BMI. DESIGN: Cross-sectional observational study. METHODS: Male (n=275) and female (n=46) soldiers performed a wide-array of physical fitness tests and military-specific tasks, including the Army physical fitness test (APFT)...
September 6, 2017: Journal of Science and Medicine in Sport
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