keyword
MENU ▼
Read by QxMD icon Read
search

Parent

keyword
https://www.readbyqxmd.com/read/29156870/a-fully-liquid-dtap-ipv-hb-prp-t-hexavalent-vaccine-for-primary-and-booster-vaccination-of-healthy-turkish-infants-and-toddlers
#1
Mehmet Ceyhan, İnci Yıldırım, Hasan Tezer, İlker Devrim, Emmanuel Feroldi
Background/aim: Immunogenicity and safety of a primary series of a fully liquid, hexavalent DTaP-IPV-HB-PRP-T vaccine given at 2, 3, and 4 months of age compared to licensed comparators and a DTaP-IPV-HB-PRP-T booster at 15?18 months were evaluated. Materials and methods: This was a Phase III, randomized, open-label trial. Primary series (no hepatitis B [HB] at birth) of DTaP-IPV-HB-PRP-T (N = 155) (group 1) or licensed control vaccines (DTaP-IPV//PRP-T and standalone HB: N = 155) (group 2) and DTaP-IPV-HB-PRP-T booster were administered...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156833/targeting-aggressive-prostate-cancer-associated-cd44v6-using-phage-display-selected-peptides
#2
Ying Peng, Austin R Prater, Susan L Deutscher
There is a crucial need to identify new biomarkers associated with aggressive prostate cancer (PCa) including those associated with cancer stem cells (CSCs). CD44v6, generated by alternative splicing of CD44, has been proposed as a CSC biomarker due to its correlation with aggressive PCa disease. We hypothesized that phage display selected peptides that target CD44v6 may serve as theranostic agents for aggressive PCa. Here, a 15 amino acid peptide ("PFT") was identified by affinity selection against a peptide derived from the v6 region of CD44v6...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156830/fbn3-gene-involved-in-pathogenesis-of-a-chinese-family-with-bardet-biedl-syndrome
#3
Yun Wang, Abir Garraoui, Liuzhi Zeng, Mingying Lai, Fen He, Huaizhou Wang, Chongyi Jiang, Yulan Chen, Lanlan Dai, Ning Fan, Huanming Yang, Jianguo Zhang, Xuyang Liu
Purpose: This study was designed to evaluate the molecular genetics of a Chinese family with Bardet-Biedl syndrome (BBS). Methods: All the family members underwent medical history evaluation, ophthalmologic and physical examinations. Whole exome sequencing was performed on two affected individuals and their parents. All variants were verified in all family members by PCR amplification and Sanger sequencing. Results: Patients in this family were diagnosed as Bardet-Biedl syndrome, with an inheritance pattern of autosomal recessive...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156708/a-preclinical-evaluation-of-the-mek-inhibitor-refametinib-in-her2-positive-breast-cancer-cell-lines-including-those-with-acquired-resistance-to-trastuzumab-or-lapatinib
#4
John O'Shea, Mattia Cremona, Clare Morgan, Malgorzata Milewska, Frankie Holmes, Virginia Espina, Lance Liotta, Joyce O'Shaughnessy, Sinead Toomey, Stephen F Madden, Aoife Carr, Naomi Elster, Bryan T Hennessy, Alex J Eustace
Purpose: The MEK/MAPK pathway is commonly activated in HER2-positive breast cancer, but little investigation of targeting this pathway has been undertaken. Here we present the results of an in vitro preclinical evaluation of refametinib, an allosteric MEK1/2 inhibitor, in HER2-positive breast cancer cell lines including models of acquired resistance to trastuzumab or lapatinib. Methods: A panel of HER2-positive breast cancer cells were profiled for mutational status and also for anti-proliferative response to refametinib alone and in combination with the PI3K inhibitor (PI3Ki) copanlisib and the HER2-targeted therapies trastuzumab and lapatinib...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156388/the-relationship-of-parental-expressed-emotion-to-co-occurring-psychopathology-in-individuals-with-autism-spectrum-disorder-a-systematic-review
#5
REVIEW
Marina Romero-Gonzalez, Susie Chandler, Emily Simonoff
Expressed emotion is a construct of the affective relationship between two people, with domains measuring criticism, hostility, warmth, relationship and emotional over-involvement. This review focuses on studies of Expressed Emotion in families of individuals with autism spectrum disorder and its association with co-occurring psychiatric disorders. A systematic search used the Psych-Info and Medline databases to identify articles available at or before September 2016. Eleven studies met the inclusion criteria...
November 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29156334/applicability-evaluation-of-advanced-processes-for-elimination-of-neurophysiological-activity-of-antidepressant-fluoxetine
#6
László Szabó, Viktória Mile, Dóra J Kiss, Krisztina Kovács, Tamás Földes, Tamás Németh, Tünde Tóth, Renáta Homlok, György T Balogh, Erzsébet Takács, László Wojnárovits
Presence of the antidepressant fluoxetine in different water bodies has raised significant concerns due to its detrimental effects on non-targeted organisms, especially on fish. When seeking for an appropriate technology able to remove fluoxetine residue from a complex water matrix, special attention needs to be paid to the elimination of the neurophysiological activity that eventually lies behind the noxious effects of the parent compound. Our aim was to probe the applicability of advanced oxidation techniques for this purpose using in situ generated free radical system based on OH-initiated peroxyl radical-mediated processes...
November 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/29156276/formation-and-degradation-of-n-oxide-venlafaxine-during-ozonation-and-biological-post-treatment
#7
Ines Zucker, Hadas Mamane, Alon Riani, Igal Gozlan, Dror Avisar
While ozonation is considered an efficient treatment to eliminate trace organic compounds (TrOCs) from secondary wastewater effluents, the presence and persistence of transformation products (TPs) resulting from ozonation of TrOCs is a major concern that should be assessed prior to effluent discharge to the environment. Venlafaxine (VLX), an environmentally relevant tertiary amine-containing TrOC, was chosen as the model for this study. TP analysis confirmed that the lone electron pair of the non-protonated amine are the predominant site of oxidant attack, and therefore strongly affected by pH value and VLX speciation...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156222/cerebral-small-vessel-disease-in-middle-age-and-genetic-predisposition-to-late-onset-alzheimer-s-disease
#8
James D Stefaniak, Li Su, Elijah Mak, Nasim Sheikh Bahaei, Katie Wells, Karen Ritchie, Adam Waldman, Craig W Ritchie, John T O'Brien
INTRODUCTION: Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOEε4) and LOAD, in older people. However, it is unclear whether CSVD begins in middle age in individuals genetically predisposed to LOAD. METHODS: We assessed the relationship between radiological markers of CSVD, white matter hyperintensities and microbleeds, and genetic predisposition to LOAD in a cross-sectional analysis of cognitively normal subjects aged 40-59 years recruited from the PREVENT Dementia study...
November 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29156211/parents-use-of-nonpharmacologic-methods-to-manage-procedural-pain-in%C3%A2-infants
#9
Tarja Pölkki, Anne Korhonen, Helena Laukkala
OBJECTIVE: To describe parents' use of nonpharmacologic methods to manage infant procedural pain in the NICU and determine the demographic factors related to such use. DESIGN: A cross-sectional and descriptive study design. SETTING: Level III and Level II NICUs (seven units) of four University Hospitals in Finland. PARTICIPANTS: Parents (N = 178) whose infants were treated in Finnish NICUs. METHODS: Parents were asked to respond to a structured questionnaire during their infants' hospitalizations...
November 17, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29156094/multiple-transmissions-of-chromosomally-integrated-human-herpesvirus-6-in-one-family
#10
Armin Rashidi, Karam Obeid, Joshua Hill, Erica D Warlick, Daniel J Weisdorf
Chromosomally integrated human herpesvirus-6 (ciHHV-6) can be transmitted from parent to child or via allogeneic hematopoietic cell transplantation (HCT). We report a case of ciHHV-6 transmitted via syngeneic HCT, and vertically across three generations. ciHHV-6 was transmitted from a parent to the patient and her identical twin, and from the patient to her son. The patient underwent syngeneic HCT as rescue from chemotherapy-induced aplasia during which ciHHV-6 was re-transmitted to her, this time from her identical twin...
November 20, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29155956/associations-between-parental-ses-and-children-s-health-related-quality-of-life-the-role-of-objective-and-subjective-social-status
#11
Kay W Kim, Jan L Wallander, Melissa Peskin, Paula Cuccaro, Marc N Elliott, Mark A Schuster
Objective: We examined (1) the relationship that parental objective social status (OSS) and subjective social status (SSS) have with children's health-related quality of life (HRQOL), (2) whether SSS mediates the association between OSS and HRQOL, and (3) whether these associations differ among Black, Latino, and White children. Method: Data came from 4,824 Black, Latino, and White 5th graders in the Healthy PassagesTM study. OSS was measured as parent educational attainment and net equivalent household income...
November 15, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29155954/the-human-papillomavirus-dna-helicase-e1-binds-stimulates-and-confers-processivity-to-cellular-dna-polymerase-epsilon
#12
Michaelle Chojnacki, Thomas Melendy
The papillomavirus (PV) helicase protein E1 recruits components of the cellular DNA replication machinery to the PV replication fork, such as Replication Protein A (RPA), DNA polymerase α-primase (pol α) and topoisomerase I (topo I). Here we show that E1 binds to DNA polymerase ϵ (pol ϵ) and dramatically stimulates the DNA synthesis activity of pol ϵ. This stimulation of pol ϵ by E1 is highly specific and occurs even in the absence of the known pol ϵ cofactors Replication Factor C (RFC), Proliferating Cell Nuclear Antigen (PCNA) and RPA...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155503/relatives-in-silent-kidney-disease-screening-risks-study-a-chinese-cohort-study
#13
Philip Kam-Tao Li, Jack Kit-Chung Ng, Yuk Lun Cheng, Tze Hoi Kwan, Chi Bon Leung, Miu Fong Lau, Koon Shing Choi, Samuel Ka-Shun Fung, Yiu Wing Ho, Siu Ka Mak, Sydney Chi-Wai Tang, Kin Shing Wong, David Yong, Sing Leung Lui
AIM: Family members of patients with end-stage renal disease (ESRD) have higher risk for chronic kidney disease (CKD). Limited study has examined the risk of developing CKD in relatives of patients in earlier stages of CKD. METHODS: From January 2008 to June 2009, the Hong Kong Society of Nephrology studied first-degree relatives of stage 1-5 CKD patients from 11 local hospitals. A total of 844 relatives of 466 index CKD patients (stages 1-2: 29.6%; stage 3: 16...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29155492/the-prevalence-of-gluten-free-diet-use-among-preschool-children-with-autism-spectrum-disorder
#14
Eric Rubenstein, Laura Schieve, Chyrise Bradley, Carolyn DiGuiseppi, Eric Moody, Kathleen Thomas, Julie Daniels
Our objective was to estimate prevalence of current or ever use of a gluten free diet (GFD) in children aged 30-68 months with autism spectrum disorder (ASD) and population controls (POP); and to identify characteristics associated with ever having used GFD among children with ASD. We used data from the Study to Explore Early Development (SEED), a multi-site, case-control study of children with ASD. Caregivers reported GFD use by their children through structured questionnaires about diet patterns, gastrointestinal (GI) issues, and ASD-specific treatments...
November 20, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29155486/toxic-stress-and-child-refugees
#15
John S Murray
The purpose of this article was to describe the phenomenon of toxic stress and its impact on the physical and mental health of child refugees. Almost two decades ago, researchers found that recurring adverse childhood events (ACEs; e.g., physical, psychological, and sexual abuse, neglect, and household dysfunction such as substance abuse, mental illness, and criminal behavior) were associated with a significant increase in serious illnesses during adulthood. Illnesses include heart, lung, and liver disease, cancer, and bone fractures...
November 20, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29155222/the-decline-in-active-school-transportation-ast-a-systematic-review-of-the-factors-related-to-ast-and-changes-in-school-transport-over-time-in-north-america
#16
REVIEW
Linda Rothman, Alison K Macpherson, Timothy Ross, Ron N Buliung
Active travel to school has declined during the last 50years in North America. During the last decade, the children's active school transportation (AST) literature has grown. This systematic review provides an updated examination of AST correlates, and discusses why school travel mode (STM) share may have changed over time. AST trends are described and a systematic literature review of AST correlates in North America for the period 1990-2016 was conducted. Strength of association between correlates and AST, and relationship direction are assessed and reported...
November 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29154977/polymer-nitric-oxide-donors-potentiate-the-treatment-of-experimental-solid-tumours-by-increasing-drug-accumulation-in-the-tumour-tissue
#17
M Studenovsky, L Sivak, O Sedlacek, R Konefal, V Horkova, T Etrych, M Kovar, B Rihova, M Sirova
The delivery of nitric oxide (NO) specifically to solid tumours was explored in this study as a strategy to augment the passive accumulation of nanomedicines in tumours induced by the Enhanced Permeability and Retention (EPR) effect. An increase in accumulation was achieved by the binding of the chemical precursor of NO, based on an organic nitrate, to a water-soluble synthetic polymer drug carrier. Four structurally different N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer NO donors were synthesized...
November 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29154903/in-vitro-mesenchymal-epithelial-transition-in-nih3t3-fibroblasts-results-in-onset-of-low-dose-radiation-hypersensitivity-coupled-with-attenuated-connexin-43-response
#18
Ankit Mathur, Ashish Kumar, Bincy Babu, Sudhir Chandna
BACKGROUND: Mesenchymal-to-epithelial transition (MET) is associated with altered cell adhesion patterns. Independent studies showed that cellular adhesion regulates low-dose hyper-radiosensitivity (HRS), a phenomenon reported widely in tumour cells. Therefore, present study aimed to investigate whether MET and associated cellular adhesion alterations affect cellular radiosensitivity. METHODS: We established multiple stages of MET by in vitro transformation of NIH3T3 mouse embryonic fibroblasts...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29154657/trajectories-of-parental-engagement-in-early-childhood-among-dual-earner-families-effects-on-child-self-control
#19
Tiago Ferreira, Joana Cadima, Marisa Matias, Joana Marina Vieira, Teresa Leal, Karine Verschueren, Paula Mena Matos
Parental engagement in positive activities with the child may show significant variation across time, assuming a crucial influence on child development. In dual-earner families, work-family conflict can interfere with parental engagement, with negative consequences for children's behavior. The current study examined the change trajectories of mothers' and fathers' engagement in early childhood, analyzing whether these trajectories are influenced by parents' work-family conflict and whether they predict child behavioral self-control...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29154654/variety-in-parental-use-of-want-relates-to-subsequent-growth-in-children-s-theory-of-mind
#20
Ted Ruffman, Aastha Puri, Olivia Galloway, Japher Su, Mele Taumoepeau
In 2 cross-lagged, longitudinal studies we contrasted parental talk about want in a single context versus multiple contexts. Study 1 examined thirty-two 2 year olds, with mothers describing pictures to children. Mothers could use want in zero, one, or multiple contexts. Children whose mothers used want in multiple contexts experienced a significantly larger gain in mental state terms over a 6-month period. Study 2 examined 50 preschoolers, measuring theory of mind (ToM) with tasks and mental state terms, then had parents intervene by reading booklets in which want was used in 1 or multiple contexts...
November 20, 2017: Developmental Psychology
keyword
keyword
20230
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"