keyword
https://read.qxmd.com/read/38514149/protocol-for-a-scoping-review-of-factors-associated-with-disparities-in-clinical-provision-of-deep-brain-stimulation
#21
JOURNAL ARTICLE
Tiffany Abramson, Rosario Aguero, Angel Arizpe, Adam Frank, Sara Kang, Xenos Mason
INTRODUCTION: Deep brain stimulation (DBS) can be used to treat several neurological and psychiatric conditions such as Parkinson's disease, epilepsy and obsessive-compulsive disorder; however, limited work has been done to assess the disparities in DBS access and implementation. The goal of this scoping review is to identify sources of disparity in the clinical provision of DBS. METHODS AND ANALYSIS: A scoping review will be conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-extension for Scoping Reviews methodology...
March 21, 2024: BMJ Open
https://read.qxmd.com/read/38513433/compulsive-rituals-in-obsessive-compulsive-disorder-a-qualitative-exploration-of-thoughts-feelings-and-behavioral-patterns
#22
JOURNAL ARTICLE
Yair Wairauch, Jedidiah Siev, Udi Hasdai, Reuven Dar
BACKGROUND AND OBJECTIVES: Rituals are common among healthy individuals and across cultures and often serve adaptive purposes. In individuals with obsessive-compulsive disorder (OCD), rituals become compulsive, time-consuming and distressing, and may lead to functional impairment. Previous research has examined the functions and characteristics of compulsive rituals, but there is paucity of in-depth, first-person reports about this topic. METHOD: We used a qualitative approach to explore thoughts, feelings, and behavioral patterns that characterize OCD rituals...
March 11, 2024: Journal of Behavior Therapy and Experimental Psychiatry
https://read.qxmd.com/read/38512149/-diagnostics-and-treatment-of-suicidality-a-matter-of-customization
#23
JOURNAL ARTICLE
K H J E Mennen, S P A Rasing, R F P de Winter, M van den Bogaard, M van den Berg, J M van Rossum, D H M Creemers
This article illustrates the importance of conducting a comprehensive analysis of suicidality through the case study of an adolescent patient dealing with both depressive disorder and obsessive-compulsive disorder. The aim of treating suicidality is to address the underlying psychiatric conditions and factors contributing to the disorder. This necessitates a thorough evaluation of the treatment environment, the establishment of continuous care, and ensuring safety. By utilizing a new model to distinguish various forms of suicidal behavior and examining suicidality as a distinct phenomenon, it becomes possible to create individualized diagnostic and treatment approaches, along with effective risk assessments...
2024: Tijdschrift Voor Psychiatrie
https://read.qxmd.com/read/38511751/study-on-symptom-dimensions-and-clinical-characteristics-in-patients-with-obsessive-compulsive-disorder
#24
JOURNAL ARTICLE
Xuan Liu, Yuehan Zhao, Pengchong Wang, Xiangyun Yang, Zhanjiang Li
BACKGROUND AND OBJECTIVE: The aim of this study was to explore the symptom dimensions and clinical characteristics of obsessive-compulsive disorder in the context of Chinese culture. METHODS: In this cross-sectional study, the severity of obsessive-compulsive symptoms, the distribution of symptoms, and symptom scores of 263 patients with obsessive-compulsive disorder were assessed using the Yale-Brown Obsessive-Compulsive Scale and Yale-Brown Obsessive-Compulsive Inventory Symptoms Checklist...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38509778/large-nesting-expression-in-deer-mice-remains-stable-under-conditions-of-visual-deprivation-despite-heightened-limbic-involvement-perspectives-on-compulsive-like-behavior
#25
JOURNAL ARTICLE
Harry Marx, Thomas E Krahe, De Wet Wolmarans
Visual stimuli and limbic activation varyingly influence obsessive-compulsive symptom expression and so impact treatment outcomes. Some symptom phenotypes, for example, covert repugnant thoughts, are likely less sensitive to sensory stimuli compared to symptoms with an extrinsic focus, that is, symptoms related to contamination, safety, and "just-right-perceptions." Toward an improved understanding of the neurocognitive underpinnings of obsessive-compulsive psychobiology, work in naturalistic animal model systems is useful...
March 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38508468/associations-between-somatomotor-putamen-resting-state-connectivity-and-obsessive-compulsive-symptoms-vary-as-a-function-of-stress-during-early-adolescence-data-from-the-abcd-study
#26
JOURNAL ARTICLE
Daniel J Petrie, Kathleen D Meeks, Zachary F Fisher, Charles F Geier
Obsessive-compulsive symptoms (OCS) are relatively common during adolescence although most individuals do not meet diagnostic criteria for obsessive-compulsive disorder (OCD). Nonetheless, OCS during adolescence are associated with comorbid psychopathologies and behavioral problems. Heightened levels of environmental stress and greater functional connectivity between the somatomotor network and putamen have been previously associated with elevated OCS in OCD patients relative to healthy controls. However, the interaction of these factors within the same sample of individuals has been understudied...
March 18, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38508457/a-network-analysis-of-mechanisms-of-change-during-exposures-over-the-course-of-intensive-ocd-treatment
#27
JOURNAL ARTICLE
Clarissa W Ong, Kate G Sheehan, Junjia Xu, Martha J Falkenstein, Jennie M Kuckertz
Exposure and response prevention (ERP) is an evidence-based treatment for obsessive-compulsive disorder (OCD). Theories for how it works vary in their emphasis on active mechanisms of change. The current study aimed to clarify mechanisms of change in ERP for OCD using network analysis, comparing ERP networks at the start and end of intensive treatment (partial hospital and residential). In our sample of 182 patients, the most central node in both networks was engagement with exposure, which was consistently related to greater understanding of ERP rationale, higher willingness, and less ritualization, accounting for all other variables in the network...
March 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38503084/mindfulness-based-cognitive-therapy-neurobiology-in-treatment-resistant-obsessive-compulsive-disorder-a-domain-related-resting-state-networks-approach
#28
JOURNAL ARTICLE
Víctor De la Peña-Arteaga, Marta Cano, Daniel Porta-Casteràs, Muriel Vicent-Gil, Neus Miquel-Giner, Ignacio Martínez-Zalacaín, Lorea Mar-Barrutia, Marina López-Solà, Jessica R Andrews-Hanna, Carles Soriano-Mas, Pino Alonso, Maria Serra-Blasco, Clara López-Solà, Narcís Cardoner
Mindfulness-based cognitive therapy (MBCT) stands out as a promising augmentation psychological therapy for patients with obsessive-compulsive disorder (OCD). To identify potential predictive and response biomarkers, this study examines the relationship between clinical domains and resting-state network connectivity in OCD patients undergoing a 3-month MBCT programme. Twelve OCD patients underwent two resting-state functional magnetic resonance imaging sessions at baseline and after the MBCT programme. We assessed four clinical domains: positive affect, negative affect, anxiety sensitivity, and rumination...
March 18, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38500080/experts-perspectives-on-the-impact-of-visual-impairment-and-comorbid-mental-disorders-on-functioning-in-essential-life-domains
#29
JOURNAL ARTICLE
Marjolein LA Onnink, Lisanne Ba Teunissen, Peter Fj Verstraten, Ruth Ma van Nispen, Hilde Pa van der Aa
BACKGROUND: Visual impairment (VI) with comorbid mental disorders (MDs) are expected to have a major impact on people's daily functioning, for which tailored support is needed. However, this has been barely investigated. Therefore, this study aimed to (1) determine the impact of VI and comorbid MDs on functioning in essential life domains, (2) gain insight into best-practices that are currently used to support this target group, and (3) determine strategies to optimize care in the future...
March 18, 2024: BMC Psychiatry
https://read.qxmd.com/read/38499363/the-dynamics-of-resting-state-eeg-and-salivary-trace-elements-in-patients-with-obsessive-compulsive-disorder
#30
JOURNAL ARTICLE
Galina Portnova, Guzal M Khayrullina, Ivan V Mikheev, Sofiya M Byvsheva, Elena V Proskurnina, Olga Martynova
The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. In this study, we tested the dynamics of behavioral parameters, resting-state electroencephalogram (EEG), and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 individuals with OCD before and after an emotional antisaccade task. The eye-movement data served as a measure of behavioral performance...
March 18, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38496634/genome-wide-association-study-identifies-new-loci-associated-with-ocd
#31
Nora I Strom, Matthew W Halvorsen, Chao Tian, Christian Rück, Gerd Kvale, Bjarne Hansen, Jonas Bybjerg-Grauholm, Jakob Grove, Julia Boberg, Judith Becker Nissen, Thomas Damm Als, Thomas Werge, Elles de Schipper, Bengt Fundin, Christina Hultman, Kira D Höffler, Nancy Pedersen, Sven Sandin, Cynthia Bulik, Mikael Landén, Elinor Karlsson, Kristen Hagen, Kerstin Lindblad-Toh, David M Hougaard, Sandra M Meier, Stéphanie Le Hellard, Ole Mors, Anders D Børglum, Jan Haavik, David A Hinds, David Mataix-Cols, James J Crowley, Manuel Mattheisen
To date, four genome-wide association studies (GWAS) of obsessive-compulsive disorder (OCD) have been published, reporting a high single-nucleotide polymorphism (SNP)-heritability of 28% but finding only one significant SNP. A sub-stantial increase in sample size will likely lead to further identification of SNPs, genes, and biological pathways mediating the susceptibility to OCD. We conducted a GWAS meta-analysis with a 2-3-fold increase in case sample size (OCD cases: N = 37,015, controls: N = 948,616) compared to the last OCD GWAS, including six previously published cohorts (OCGAS, IOCDF-GC, IOCDF-GC-trio, NORDiC-nor, NORDiC-swe, and iPSYCH) and unpublished self-report data from 23andMe Inc...
March 8, 2024: medRxiv
https://read.qxmd.com/read/38494948/common-pitfalls-and-how-to-avoid-them-in-child-and-adolescent-psychopharmacology-part-i
#32
REVIEW
Samuele Cortese, Frank Mc Besag, Bruce Clark, Chris Hollis, Joe Kilgariff, Carmen Moreno, Dasha Nicholls, Paul Wilkinson, Marc Woodbury-Smith, Aditya Sharma
As Faculty of the British Association for Psychopharmacology course on child and adolescent psychopharmacology, we present here what we deem are the most common pitfalls, and how to avoid them, in child and adolescent psychopharmacology. In this paper, we specifically addressed common pitfalls in the pharmacological treatment of attention-deficit/hyperactivity disorder, anxiety, bipolar disorder, depression, obsessive-compulsive disorder and related disorders, and tic disorder. Pitfalls in the treatment of other disorders are addressed in a separate paper (part II)...
March 18, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38494136/two-multimodal-neuroimaging-subtypes-of-obsessive-compulsive-disorder-disclosed-by-semi-supervised-machine-learning
#33
JOURNAL ARTICLE
Zhipeng Ding, Tinghuizi Shang, Zhenning Ding, Xu Yang, Jiale Qi, Xiaoqing Qin, Yunhui Chen, Dan Lv, Tong Li, Jidong Ma, Chuang Zhan, Jian Xiao, Zhenghai Sun, Na Wang, Zengyan Yu, Chengchong Li, Ping Li
BACKGROUND: Obsessive-compulsive disorder (OCD) is a highly heterogeneous mental condition with a diverse symptom. Existing studies classified OCD on the basis of conventional phenomenology-based taxonomy ignoring the fact that the same subtype identified in accordance with clinical symptom may have different mechanisms and treatment responses. METHODS: This research involved 50 medicine-free patients with OCD and 50 matched healthy controls (HCs). All the participants were subjected to structural and functional magnetic resonance imaging (MRI)...
March 15, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38494099/the-relationship-between-oxidative-stress-markers-and-1h-magnetic-resonance-spectroscopy-findings-in-obsessive-compulsive-disorder
#34
JOURNAL ARTICLE
Fatma Subaşı Turgut, Mahmut Bulut, Salih Hattapoğlu, Mehmet Güneş, Mehmet Cemal Kaya, Faysal Ekici, Mehmet Guli Çetinçakmak, İbrahim Kaplan, Murad Atmaca
INTRODUCTION: The purpose of this study was to examine N-acetyl aspartate (NAA)/creatine (Cr) and glutamate, glutamine, and gamma-aminobutyric acid complex (Glx)/Cr levels in patients with obsessive compulsive disorder (OCD) and healthy controls' orbitofrontal cortex (OFC) and caudate nucleus (CN) by proton magnetic resonance spectroscopy (1H-MRS) method and to investigate their relationship with oxidative stress markers glutathione peroxidase (GPx) and superoxide dismutase (SOD). METHODS: This study included patients with OCD (n = 25) and healthy controls (n = 25) ranging in age from 18 to 65...
March 15, 2024: Brain Research
https://read.qxmd.com/read/38493236/predictors-of-health-related-quality-of-life-for-children-with-neurodevelopmental-conditions
#35
JOURNAL ARTICLE
Maryam Mahjoob, Robyn Cardy, Melanie Penner, Evdokia Anagnostou, Brendan F Andrade, Jennifer Crosbie, Elizabeth Kelley, Muhammad Ayub, Muhammad Ayub, Jessica Brian, Alana Iaboni, Russell Schachar, Stelios Georgiades, Rob Nicolson, Jessica Jones, Azadeh Kushki
Neurodevelopmental conditions can be associated with decreased health-related quality of life; however, the predictors of these outcomes remain largely unknown. We characterized the predictors of health-related quality of life (HRQoL) in a sample of neurodiverse children and youth. We used a cross-sectional subsample from the Province of Ontario Neurodevelopmental Disorders Network (POND) consisting of those children and young people in the POND dataset with complete study data (total n = 615; 31% female; age: 11...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493169/neural-inhibition-as-implemented-by-an-actor-critic-model-involves-the-human-dorsal-striatum-and-ventral-tegmental-area
#36
JOURNAL ARTICLE
Ana Araújo, Isabel Catarina Duarte, Teresa Sousa, Joana Oliveira, Ana Telma Pereira, António Macedo, Miguel Castelo-Branco
Inhibition is implicated across virtually all human experiences. As a trade-off of being very efficient, this executive function is also prone to many errors. Rodent and computational studies show that midbrain regions play crucial roles during errors by sending dopaminergic learning signals to the basal ganglia for behavioural adjustment. However, the parallels between animal and human neural anatomy and function are not determined. We scanned human adults while they performed an fMRI inhibitory task requiring trial-and-error learning...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38486096/acceptability-of-internet-delivered-cognitive-behavioural-therapy-for-adults-with-symptoms-of-obsessive-compulsive-disorder-a-meta-analysis
#37
JOURNAL ARTICLE
Shifra Waks, Karen Moses, Bethany M Wootton
OBJECTIVES: Obsessive-compulsive disorder (OCD) is a chronic mental health disorder. Internet-delivered cognitive behaviour therapy (ICBT) is demonstrated to be effective for OCD; however little is known about the acceptability of the treatment. Therefore the aim of this study was to examine the acceptability of ICBT for adults with OCD symptoms using a meta-analytic approach. METHOD: Seventeen studies (N = 1661; Mage range = 28-41 years; 58%-93% female) were included in this analysis...
March 14, 2024: British Journal of Clinical Psychology
https://read.qxmd.com/read/38481168/reduced-subjective-cognitive-concerns-with-neurobehavioral-therapy-in-functional-seizures-and-traumatic-brain-injury
#38
JOURNAL ARTICLE
Ryan Van Patten, Lawrence Chan, Krista Tocco, Kristen Mordecai, Hamada Altalib, Erica Cotton, Stephen Correia, Tyler E Gaston, Leslie P Grayson, Amber Martin, Samantha Fry, Adam Goodman, Jane B Allendorfer, Jerzy Szaflarski, W Curt LaFrance
OBJECTIVE: Functional seizures are common among people with traumatic brain injury (TBI). Subjective cognitive concerns refer to a person's own perception of problems with cognitive functioning in everyday life. The authors investigated the presence and correlates of subjective cognitive concerns and the response to neurobehavioral therapy among adults with TBI and functional seizures (TBI+FS group). METHODS: In this observational study, participants in the TBI+FS group (N=47) completed a 12-session neurobehavioral therapy protocol for seizures, while participants in the comparison group (TBI without seizures) (N=50) received usual treatment...
March 14, 2024: Journal of Neuropsychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38479247/fear-of-negative-evaluation-and-intolerance-of-uncertainty-assessing-potential-internalizing-correlates-of-eating-disorder-related-clinical-impairment-and-differences-across-diagnostic-presentations
#39
JOURNAL ARTICLE
Angeline R Bottera, Elizabeth N Dougherty, Sophia Todorov, Jennifer E Wildes
The Hierarchical Taxonomy of Internalizing Dimensions for Eating Disorders model positions eating disorder (ED) symptoms on an internalizing dimension alongside anxiety and mood symptoms. Symptom dimensions falling under the internalizing subfactors of distress (e.g., social anxiety) and fear/avoidance (e.g., panic, compulsions, checking) may differentially guide treatment. We examined relations between fear of negative evaluation and intolerance of uncertainty (core features of social anxiety and obsessive-compulsive disorder, respectively) and ED-related impairment and potential diagnostic differences...
March 5, 2024: Eating Behaviors
https://read.qxmd.com/read/38478366/silymarin-milk-thistle-treatment-of-adults-with-gambling-disorder-a-double-blind-placebo-controlled-trial
#40
JOURNAL ARTICLE
Jon E Grant, Corine Driessens, Samuel R Chamberlain
OBJECTIVE: Data on the pharmacological treatment of gambling disorder are limited. Silymarin (derived from milk thistle) has antioxidant properties. The goal of the current study was to determine the efficacy and tolerability of silymarin in adults with gambling disorder. METHODS: Forty-three individuals (18 [41.9%] women; mean age=49.61 [±13.1] years) with gambling disorder entered an 8-week, double-blind, placebo-controlled study. Dosing of silymarin ranged from 150 to 300 mg twice a day...
March 2024: Clinical Neuropharmacology
keyword
keyword
20229
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.