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Obsessive Compulsive

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https://www.readbyqxmd.com/read/29161610/experimental-modification-of-dysfunctional-interpretations-in-individuals-with-contamination-concerns
#1
Sara L Conley, Kevin D Wu
BACKGROUND AND OBJECTIVES: Dysfunctional interpretations of intrusive thoughts are implicated in the etiology and maintenance of Obsessive-Compulsive Disorder (OCD). Cognitive Bias Modification training for interpretations (CBM-I) has successfully modified dysfunctional interpretations in the context of several disorders, including OCD. However, research regarding CBM-I's impact on symptom reduction and behavior is mixed, which limits its clinical application. Further, support for the specific efficacy of CBM-I in individuals with contamination concerns is limited...
November 15, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29159060/association-between-hippocampus-volume-and-symptom-profiles-in-obsessive-compulsive-disorder
#2
Tim Jonas Reess, Oana Georgiana Rus, Deniz A Gürsel, Benita Schmitz-Koep, Gerd Wagner, Götz Berberich, Kathrin Koch
Background: The hippocampus has recently been identified to play a key role in the pathophysiology of adult obsessive-compulsive disorder (OCD). Surprisingly, there is only limited evidence regarding the potential relationships with symptom dimensions. Due to the heterogeneity of symptoms in OCD, we aimed at further examining, whether hippocampal volume differences might be related to symptom profiles instead of single symptom dimensions. Methods: In order to find out more about the potential association between clinical symptom profiles and alterations in hippocampal volume we categorized a large sample of OCD patients (N = 66) into distinct symptom profile groups using K-means clustering...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159055/neural-correlates-of-working-memory-deficits-and-associations-to-response-inhibition-in-obsessive-compulsive-disorder
#3
Stephan Heinzel, Christian Kaufmann, Rosa Grützmann, Robert Hummel, Julia Klawohn, Anja Riesel, Katharina Bey, Leonhard Lennertz, Michael Wagner, Norbert Kathmann
Previous research in patients with obsessive-compulsive disorder (OCD) has indicated performance decrements in working memory (WM) and response inhibition. However, underlying neural mechanisms of WM deficits are not well understood to date, and empirical evidence for a proposed conceptual link to inhibition deficits is missing. We investigated WM performance in a numeric n-back task with four WM load conditions during functional Magnetic Resonance Imaging (fMRI) in 51 patients with OCD and 49 healthy control participants who were matched for age, sex, and education...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29158881/serum-proteomic-profiling-of-obsessive-compulsive-disorder-washing-subtype-a-preliminary-study
#4
Mona Zamanian-Azodi, Mostafa Rezaei-Tavirani, Naser Nejadi, Afsaneh Arefi Oskouie, Faird Zayeri, Mostafa Hamdieh, Akram Safaei, Majid Rezaei-Tavirani, Alireza Ahmadzadeh, Alireza Amouzandeh-Nobaveh, Farshad Okhovatian
Introduction: Obsessive-Compulsive Disorder (OCD) is a disabling mental condition that its proteomic profiling is not yet investigated. Proteomics is a valuable tool to discover biomarker approaches. It can be helpful to detect protein expression changes in complex disorders such as OCD. Methods: Here, by the application of 2D gel electrophoresis (2DE), a pilot study of serum proteome profile of females with washing subtype of OCD was performed. Serum samples were obtained from females with washing subtype of OCD...
July 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29158148/comparing-escitaloipram-with-sertraline-for-obsessive-and-compulsive-symptoms-in-patients-with-obsessive-compulsive-disorder-a-comparative-double-blind-clinical-trial
#5
Arash Mowla, Farzaneh Modarresi, Seyed Ali Dastgheib
BACKGROUND: Escitalopram has some unique features among selective serotonin reuptake inhibitors. The aim of this survey is to compare the efficacy of escitalopram with sertraline on obsessive and compulsive symptoms in patients with Obsessive Compulsive Disorder (OCD). METHODS: In this 12-week double blind controlled randomized clinical trial, 57 patients with OCD were randomly allocated to receive escitalopram or sertraline. Yale Brown obsessive compulsive behavior scale (YBOCS) was used to assess the outcomes...
November 7, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29156296/associations-between-severity-of-anxiety-and-clinical-and-biological-features-of-major-affective-disorders
#6
Fernanda Liboni Cavicchioli, Michael Maes, Chutima Roomruangwong, Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, George Anderson, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes
Patients with major affective disorders (MAFD) with comorbid anxiety show a greater functional impairment than those without anxiety. The aim of this study is to delineate the associations between severity of anxiety in MAFD, namely bipolar disorder (BD) and major depression (MDD), and MAFD characteristics and serum high-density lipoprotein (HDL)-cholesterol levels. Recruited were 82 participants with anxiety disoders and 83 without anxiety disoders, including 101 MAFD patients and 51 healthy controls. We used the Hamilton Anxiety Rating Scale (HAM-A) to measure severity of anxiety and made the diagnoses of posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD) and phobias...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29154502/if-it-is-absurd-then-why-do-you-do-it-the-richer-the-obsessional-experience-the-more-compelling-the-compulsion
#7
Steffen Moritz, Christine Purdon, Lena Jelinek, Brenda Chiang, Marit Hauschildt
Mounting evidence suggests that obsessive intrusions are often accompanied and amplified by perceptual experiences of different modalities (e.g., feeling dirt on one's skin while experiencing intrusive thoughts about contamination). Pilot studies conducted online with individuals endorsing mild obsessive-compulsive symptoms have linked the co-occurrence of perceptual experiences and obsessions to the severity of subsequent compulsive behaviour as well as low insight. However, it is presently unclear whether sensory experiences accompany all types of obsessional thoughts or are restricted to certain preoccupations (e...
November 20, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29153958/major-and-minor-life-events-personality-and-psychopathology-in-children-with-tourette-syndrome
#8
Netta Horesh, Sharona Shmuel-Baruch, Dan Farbstein, Daphna Ruhrman, Noa Ben Aroya Milshtein, Silvana Fennig, Alan Apter, Tamar Steinberg
Environmental, psychological, and biological interactions underlie many psychopathologies. Tourette's Syndrome (TS) has an obvious biological substrate but environmental factors and personality play substantial roles in its expression. We aimed to study the interrelationships between stressful life events, personality traits, tics, and comorbid disorders in children with TS. To this end, 132 children with TS and 49 healthy controls were recruited for the study. Major life events in the 12-months prior to testing and minor life events in the month prior to testing were retrospectively assessed using the Life Experiences Survey (LES) and the Brief Adolescent Life Events Scale (BALES), respectively...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29153927/1hz-rtms-of-the-right-orbitofrontal-cortex-for-major-depression-safety-tolerability-and-clinical-outcomes
#9
Kfir Feffer, Peter Fettes, Peter Giacobbe, Zafiris J Daskalakis, Daniel M Blumberger, Jonathan Downar
Conventional rTMS in major depressive disorder (MDD) targets the dorsolateral prefrontal cortex (DLPFC). However, many patients do not respond to DLPFC-rTMS. Recent evidence suggests that the right lateral orbitofrontal cortex (OFC) plays a key role in 'non-reward' functions and shows hyperconnectivity in MDD. OFC-rTMS has been used successfully in obsessive-compulsive disorder, and achieved remission in an MDD case nonresponsive to DLPFC- and DMPFC-rTMS. Here, we assess the safety and tolerability of right OFC-rTMS, and examine the effectiveness of inhibitory right OFC-rTMS in MDD, particularly among patients with previous nonresponse to DMPFC-rTMS...
November 16, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29152901/broad-spectrum-of-neuropsychiatric-phenotypes-associated-with-white-matter-disease-in-pten-hamartoma-tumor-syndrome
#10
Tugce B Balci, Jorge Davila, Denice Lewis, Addo Boafo, Erick Sell, Julie Richer, Sarah M Nikkel, Christine M Armour, Eva Tomiak, Matthew A Lines, Sarah L Sawyer
White matter lesions have been described in patients with PTEN hamartoma tumor syndrome (PHTS). How these lesions correlate with the neurocognitive features associated with PTEN mutations, such as autism spectrum disorder (ASD) or developmental delay, has not been well established. We report nine patients with PTEN mutations and white matter changes on brain magnetic resonance imaging (MRI), eight of whom were referred for reasons other than developmental delay or ASD. Their clinical presentations ranged from asymptomatic macrocephaly with normal development/intellect, to obsessive compulsive disorder, and debilitating neurological disease...
November 20, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29152825/feasibility-study-combining-art-therapy-or-cognitive-remediation-therapy-with-family-based-treatment-for-adolescent-anorexia-nervosa
#11
James Lock, Kathleen Kara Fitzpatrick, William S Agras, Noam Weinbach, Booil Jo
Adolescents with anorexia nervosa who have obsessive-compulsive (OC) features respond poorly to family-based treatment (FBT). This study evaluated the feasibility of combining FBT with either cognitive remediation therapy (CRT) or art therapy (AT) to improve treatment response in this at-risk group. Thirty adolescents with anorexia nervosa and OC features were randomized to 15 sessions of FBT + CRT or AT. Recruitment rate was 1 per month, and treatment attrition was 16.6% with no differences between groups...
November 20, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29152502/target-specific-deep-brain-stimulation-of-the-ventral-capsule-ventral-striatum-for-the-treatment-of-neuropsychiatric-disease
#12
Chencheng Zhang, Dianyou Li, Haiyan Jin, Kristina Zeljic, Bomin Sun
Deep brain stimulation (DBS) is a well-established therapy for Parkinson's disease and other movement disorders. An accumulating body of evidence supports the extension of DBS application for the treatment of refractory psychiatric disorders. The ventral capsule/ventral striatum (VC/VS) is the most common anatomical target for obsessive-compulsive disorder (OCD), addiction, and depression. However, no specific electrode is available for the clinical targeting of these areas for DBS. According to the anatomical features of the VC/VS, a novel electrode was developed for simultaneous and independently programmed stimulation of the nucleus accumbens (NAc) and the anterior limb of the internal capsule (ALIC)...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29149756/residual-anxiety-may-be-associated-with-depressive-relapse-during-continuation-therapy-of-bipolar-ii-depression
#13
Lorenzo Lorenzo-Luaces, Jay D Amsterdam, Robert J DeRubeis
BACKGROUND: Anxiety symptoms are common in bipolar disorder. We explored the effect of anxiety on the outcome of acute and continuation pharmacotherapy of bipolar II depression. METHODS: Data were derived from a randomized double-blind 12-week acute (N = 129) and 6-month continuation (N = 55) comparison of venlafaxine versus lithium monotherapy in bipolar II depression in adults. We distinguished between the items of the Hamilton Rating Scale for Depression (HRSD) that capture depression vs...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29148122/altered-frontal-interhemispheric-and-fronto-limbic-structural-connectivity-in-unmedicated-adults-with-obsessive-compulsive-disorder
#14
Xiaofu He, Emily Steinberg, Mihaela Stefan, Martine Fontaine, H Blair Simpson, Rachel Marsh
BACKGROUND: Previous diffusion tensor imaging (DTI) studies of obsessive-compulsive disorder (OCD) have primarily used voxel- or tract-based methods to assess white matter microstructure in medicated patients. This is the first probabilistic tractography study to assess the structural connectivity of all major white matter tracts in unmedicated adults with OCD without comorbid psychopathology. We hypothesized that OCD compared to healthy participants would show reduced integrity in frontal interhemispheric and fronto-limbic tracts...
November 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29145184/addictive-non-drug-and-obsessive-compulsive-symptoms-after-focal-brain-lesions
#15
René M Müri, Dario Cazzoli
This chapter presents an overview of different addictive and obsessive-compulsive symptoms and their constellations due to focal brain lesions. In general, such symptoms are not systematically reported in the literature, and the knowledge about the networks involved is sometimes sparse. Finally, we present an original case with an unusual combination of kleptomania and hyper-religiosity.
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29141254/role-of-glutamatergic-system-in-obsessive-compulsive-disorder-with-possible-therapeutic-implications
#16
Přemysl Vlček, Jakub Polák, Martin Brunovský, Jiří Horáček
No abstract text is available yet for this article.
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29141084/association-of-obsessive-compulsive-disorder-with-objective-indicators-of-educational-attainment-a-nationwide-register-based-sibling-control-study
#17
Ana Pérez-Vigil, Lorena Fernández de la Cruz, Gustaf Brander, Kayoko Isomura, Andreas Jangmo, Inna Feldman, Eva Hesselmark, Eva Serlachius, Luisa Lázaro, Christian Rück, Ralf Kuja-Halkola, Brian M D'Onofrio, Henrik Larsson, David Mataix-Cols
Importance: To our knowledge, the association of obsessive-compulsive disorder (OCD) and academic performance has not been objectively quantified. Objective: To investigate the association of OCD with objectively measured educational outcomes in a nationwide cohort, adjusting for covariates and unmeasured factors shared between siblings. Design, Setting, And Participants: This population-based birth cohort study included 2 115 554 individuals who were born in Sweden between January 1, 1976, and December 31, 1998, and followed up through December 31, 2013...
November 15, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29139125/validation-of-the-distress-tolerance-scale-short-form-in-obsessive-compulsive-disorder
#18
Lauryn E Garner, Nathaniel Van Kirk, Eric D Tifft, Jason W Krompinger, Brittany M Mathes, Maria Fraire, Martha J Falkenstein, Brian P Brennan, Jesse M Crosby, Jason A Elias
OBJECTIVE: This study aimed to develop and validate the Distress Tolerance Scale-Short Form (DTS-SF), a modification of the original Distress Tolerance Scale, in a severe/complex sample of individuals with obsessive compulsive disorder (OCD). Currently, there are multiple self-report measurements of distress tolerance (DT), highlighting the need for a more refined measure. METHOD: Participants included 222 individuals with a primary diagnosis of OCD (57% male, average age = 31) seeking intensive/residential treatment...
November 15, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29134496/an-analysis-of-treatment-seeking-behavior-in-individuals-with-gambling-disorder
#19
Michael D Harries, Sarah A Redden, Jon E Grant
Gambling disorder affects approximately 1.1-3.5% of the population, with the rates being higher in young adults. Despite this high prevalence, little is known regarding which pathological gamblers decide to seek treatment. This study sought to examine the differences in three groups of pathological gamblers: those who did not seek treatment (n = 94), those who sought therapy (n = 106) and those who sought medication therapy (n = 680). All subjects were assessed on a variety of measures including demographics, family history, gambling history, comorbid psychiatric disorders and an assortment of clinical variables such as the Quality of Life Inventory, Hamilton Depression and Anxiety Rating Scales, Yale Brown Obsessive Compulsive Scale for Pathologic Gambling (PG-YBOCS), Barratt Impulsiveness Scale, Eysenck Impulsiveness Questionnaire and select cognitive tasks...
November 13, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/29133949/a-total-population-multigenerational-family-clustering-study-of-autoimmune-diseases-in-obsessive-compulsive-disorder-and-tourette-s-chronic-tic-disorders
#20
D Mataix-Cols, E Frans, A Pérez-Vigil, R Kuja-Halkola, C Gromark, K Isomura, L Fernández de la Cruz, E Serlachius, J F Leckman, J J Crowley, C Rück, C Almqvist, P Lichtenstein, H Larsson
The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013...
November 14, 2017: Molecular Psychiatry
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