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https://www.readbyqxmd.com/read/29927399/-cerebral-atherosclerosis-a-biomarker-profile
#1
M M Tanashyan, O V Lagoda, A N Evdokimenko, A A Shabalina, A A Raskurazhev
AIM: To assess the changes in several biomarkers in patients with atherosclerosis of brachiocephalic arteries and shape a biomarker profile of cerebral atherosclerosis as an integrative index. MATERIAL AND METHODS: The study included 124 patients with atherosclerotic lesions of internal carotid arteries (82 men and 42 women) aged from 37 to 73 years. The patients were stratified by history of prior stroke into 'asymptomatic' and 'symptomatic'. Along with general clinical and neurological examinations, ultrasound analysis of brachiocephalic arteries, neuroimaging, identification of biomarkers reflecting different stages of atherogenesis and evaluation of pathomorphological parameters of atherosclerotic plaques removed during carotid endarterectomy surgery were performed...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29925330/features-of-branch-occlusive-disease-type-intracranial-atherosclerotic-stroke-in-young-patients
#2
Zhang-Ning Zhao, Xiao-Lin Li, Jin-Zhi Liu, Zhi-Ming Jiang, Ai-Hua Wang
BACKGROUND: Young ischemic stroke patients are common while classification and analysis based upon imaging characteristics are rarely reported. We intend to compare the clinical and MRI characteristics of cerebral stroke induced by intracranial atherosclerosis between young patients with branch occlusive disease (BOD) and those with non-branch occlusive disease (non-BOD) or small artery disease (SAD). METHODS: A total of 151 subjects with acute infarction within the middle cerebral artery (MCA) territory were included and patients with ipsilateral internal carotid artery stenosis or cardioembolism were excluded...
June 20, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29925174/-management-of-blood-pressure-in-acute-ischemic-stroke-a-meta-analysis
#3
Q Huang, J Z Zhang, J Wu
Objective: We are aiming at conducting a meta-analysis of the literature to elucidate the efficacy and safety of anti-hypertension therapy in acute stage of ischemic stroke (AIS). Methods: Researches on the efficacy and safety of anti-hypertension therapy published on PubMed before 1st September 2017 were independently retrieved by two authors.Clinical benign prognosis and death measured as modified Rankin Scale (mRS) ≤2 and mRS=6 were taken as primary indicators of efficacy and safety, respectively.A meta-analysis of included randomized controlled trials (RCTs) was performed by RevMan 5...
June 19, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29925127/-the-effects-of-levosimendan-on-the-cardiac-function-and-prognosis-in-elderly-patients-with-septic-shock-and-myocardial-contractility-impairment
#4
C X Xu, L Li, S J Gong, Y H Yu, J Yan
Objective: To investigate the effect of levosimendan on cardiac function and prognosis in elderly patients with septic myocardial contractility impairment. Methods: A prospective, randomized, controlled study was conducted. The elderly patients with septic myocardial contractility impairment who were admitted to Intensive Care Unit in Zhejiang Hospital were consecutively enrolled from January 2017 to September 2017. The key inclusive criterion was left ventricular ejection fraction (LVEF) ≤50% after fluid resuscitation...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29921571/marital-status-and-risk-of-cardiovascular-diseases-a-systematic-review-and-meta-analysis
#5
Chun Wai Wong, Chun Shing Kwok, Aditya Narain, Martha Gulati, Anastasia S Mihalidou, Pensee Wu, Mirvat Alasnag, Phyo Kyaw Myint, Mamas A Mamas
BACKGROUND: The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD. METHODS: A search of MEDLINE and Embase in January 2018 without language restriction was performed to identify studies that evaluated the association between marital status and risk of CVD. Search terms related to both marital status and CVD were used and included studies had to be prospective in design...
June 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29917150/primary-stroke-prevention-a-paradigm-shift-focusing-on-silent-paroxysmal-atrial-fibrillation
#6
Ami Schattner
We review the prevalence, predictability, prognosis, and preventability of atrial fibrillation and associated cardiogenic brain embolism, focusing on 'silent' subclinical atrial fibrillation (SCAF) which is very common in the elderly, and associated with significantly increased risk of stroke and cardiovascular mortality. The current paradigm treats atrial fibrillation once discovered by its symptoms, complications (stroke) or by chance, and screening recommendations are limited to opportunistic pulse palpation...
June 18, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29915769/rhupus-syndrome-and-chiari-s-network
#7
Gokhan Sargin, Taskin Senturk, Songul Cildag
A 69-year-old female patient was admitted to our clinic with photosensitivity, symmetric erosive polyarthritis, and cutaneous vasculitis of lower extremities. Rhupus syndrome was diagnosed, and Chiari's network in the right atrium and interatrial septum patent foramen ovale was achieved on transthoracic and transesophageal echocardiography. If it is thought that increased prevalence of antiphospholipid antibodies in patients with rhupus, this congenital remnant is important for the thrombosis risk, cardiac event, and stroke...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915120/efficacy-of-endovascular-therapy-in-acute-ischemic-stroke-depends-on-age-and-clinical-severity
#8
Raphaël Le Bouc, Frédéric Clarençon, Elena Meseguer, Bertrand Lapergue, Arturo Consoli, Guillaume Turc, Olivier Naggara, Duc Long Duong, Jerome Servan, Peggy Reiner, Marc Antoine Labeyrie, Mathieu Fisselier, Raphaël Blanc, Wassim Farhat, Christine Pires, Mathieu Zuber, Michael Obadia, Mikael Mazighi, Fernando Pico, Jean-Louis Mas, Pierre Amarenco, Yves Samson
BACKGROUND AND PURPOSE: Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients' age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, or poor prognostic score. METHODS: A total of 4079 patients with an acute ischemic stroke were identified from the Paris Stroke Consortium registry...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29914832/quantification-of-aortic-shagginess-as-a-predictive-factor-of-perioperative-stroke-and-long-term-prognosis-after-endovascular-treatment-of-aortic-arch-disease
#9
Akihiro Hosaka, Manabu Motoki, Masaaki Kato, Hiroko Sugai, Nobukazu Okubo
OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) with supra-aortic debranching has recently been introduced as a treatment option for aortic arch disease. Although less invasive than open repair, TEVAR is associated with a risk of perioperative embolic stroke due to dislodgment of atherosclerotic plaque debris, especially in individuals with atheromatous degeneration of the aortic lumen. It is difficult to determine atheroma vulnerability, and there is no current method for predicting the risk of atheroembolism...
June 15, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29907351/dietary-sodium-sodium-to-potassium-ratio-and-risk-of-stroke-a-systematic-review-and-nonlinear-dose-response-meta-analysis
#10
Ahmad Jayedi, Farnoosh Ghomashi, Mahdieh Sadat Zargar, Sakineh Shab-Bidar
BACKGROUND & AIMS: The association of high sodium intake with risk of stroke has been accepted. But considering the proposed J/U-shaped association between sodium intake and risk of all-cause mortality, the shape of the dose-response relationship has not been determined yet. This study aimed to test the dose-response association of dietary sodium and sodium-to-potassium ratio with risk of stroke in adults aged 18 years or older. METHODS: We performed a systematic search using PubMed and Scopus, from database inception up to October 2017...
June 1, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29903395/incidence-prognosis-and-prediction-of-haemorrhagic-transformation-after-revascularisation-for-stroke
#11
P B García Jurado, E Roldán Romero, M E Pérez Montilla, R Valverde Moyano, I M Bravo Rey, F Delgado Acosta, F A Bravo-Rodríguez
INTRODUCTION: Haemorrhagic transformation is a major complication of acute ischaemic stroke (AIS). We sought to determine the predictors and clinical impact of intracranial haemorrhage (ICH) after revascularisation therapy. METHODS: We conducted a retrospective, single-centre study including 235 patients with AIS who underwent intravenous recombinant tissue plasminogen activator (IV-rtPA) therapy and/or endovascular treatment. A binary logistic regression model was used to determine the variables associated with ICH, parenchymal haematomas (PH), modified Rankin Scale (mRS) scores, and mortality...
June 11, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29903393/one-year-prognosis-of-non-traumatic-cortical-subarachnoid-haemorrhage-a-prospective-series-of-34-patients
#12
R F Galiano Blancart, G Fortea, A Pampliega Pérez, S Martí, V Parkhutik, A V Sánchez Cruz, C Soriano, D Geffner Sclarsky, M T Pérez Saldaña, N López Hernández, I Beltrán, A Lago Martín
INTRODUCTION: Cortical subarachnoid haemorrhage (cSAH) has multiple aetiologies. No prospective study has reported the long-term progression of the condition. The objective of this study is to describe the clinical and aetiological characteristics of patients with cSAH and to gain insight into prognosis. METHODS: We performed a prospective, observational, multi-centre study. Data on clinical and radiological variables were collected; during a one-year follow-up period, we recorded data on mortality, dependence, rebleeding, and the appearance of dementia...
June 11, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29900874/dabigatran-in-patients-with-myocardial-injury-after-non-cardiac-surgery-manage-an-international-randomised-placebo-controlled-trial
#13
P J Devereaux, Emmanuelle Duceppe, Gordon Guyatt, Vikas Tandon, Reitze Rodseth, Bruce M Biccard, Denis Xavier, Wojciech Szczeklik, Christian S Meyhoff, Jessica Vincent, Maria Grazia Franzosi, Sadeesh K Srinathan, Jason Erb, Patrick Magloire, John Neary, Mangala Rao, Prashant V Rahate, Navneet K Chaudhry, Bongani Mayosi, Miriam de Nadal, Pilar Paniagua Iglesias, Otavio Berwanger, Juan Carlos Villar, Fernando Botto, John W Eikelboom, Daniel I Sessler, Clive Kearon, Shirley Pettit, Mukul Sharma, Stuart J Connolly, Shrikant I Bangdiwala, Purnima Rao-Melacini, Andreas Hoeft, Salim Yusuf
BACKGROUND: Myocardial injury after non-cardiac surgery (MINS) increases the risk of cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran prevents perioperative venous thromboembolism, but whether this drug can prevent a broader range of vascular complications in patients with MINS is unknown. The MANAGE trial assessed the potential of dabigatran to prevent major vascular complications among such patients. METHODS: In this international, randomised, placebo-controlled trial, we recruited patients from 84 hospitals in 19 countries...
June 9, 2018: Lancet
https://www.readbyqxmd.com/read/29900089/staphylococcus-lugdunensis-endocarditis-and-cerebrovascular-accident-a-systemic-review-of-risk-factors-and-clinical-outcome
#14
REVIEW
Htoo Kyaw, Felix Raju, Atif Z Shaikh, Aung Naing Lin, Aye T Lin, Joseph Abboud, Sarath Reddy
Infective endocarditis (IE) secondary to Staphylococcus lugdunensis has been increasingly recognized since 1988. IE-related thromboembolism represents an associated complication of the disease and carries a dismal prognosis. However, the incidence of cerebrovascular accident secondary to S. lugdunensis IE is relatively uncommon and its treatment has not been clearly elucidated yet. We performed an extensive literature search using Pubmed, Medline, Scopus, and Google Scholar to identify the articles using the following keywords: 'Staphylococcus lugdunensis', 'infective endocarditis', 'stroke', and 'cerebrovascular accident...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29898850/prognosis-in-relation-to-high-sensitivity-cardiac-troponin-t-levels-in-patients-with-myocardial-infarction-and-non-obstructive-coronary-arteries
#15
Marcus Hjort, Bertil Lindahl, Tomasz Baron, Tomas Jernberg, Per Tornvall, Kai M Eggers
BACKGROUND: Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) is a recently recognized condition where biomarkers and prognosis are less well studied than in MI with obstructive coronary artery disease (MI-CAD). We therefore aimed to investigate the one-year prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) levels in MINOCA in comparison to MI-CAD. METHODS: In this registry-based cohort study, we used data from patients with a discharge diagnosis of MI, admitted between 2009 and 2013 to Swedish hospitals using the hs-cTnT assay...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29898084/the-history-of-basilar-artery-occlusion-when-art-aids-science
#16
Francisco Antunes Dias, Daniel Giansante Abud, Octavio Marques Pontes-Neto
Basilar artery occlusion (BAO) ischemic stroke is a relatively rare condition with high morbidity and mortality rates. To date, the best acute reperfusion therapy for BAO has still not been established, mainly due to the lack of randomized controlled trials in this field. In this article, we review the history of BAO diagnosis and treatment, and the impact of modern technological resources on the clinical evolution and prognosis of BAO over time. Furthermore, we describe historical events and nonmedical literature descriptions related to BAO...
May 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29896437/the-short-term-prognostic-value-of-the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-acute-ischemic-stroke
#17
Qi-Wen Deng, Shuo Li, Huan Wang, Leix Lei, Han-Qing Zhang, Zheng-Tian Gu, Fang-Lan Xing, Fu-Ling Yan
The triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) is a simple approach to predicting unfavorable outcomes in cardiovascular disease. The influence of TG/HDL-C on acute ischemic stroke remains elusive. The purpose of this study was to investigate the precise effect of TG/HDL-C on 3-month mortality after acute ischemic stroke (AIS). Patients with AIS were enrolled in the present study from 2011 to 2017. A total of 1459 participants from a single city in China were divided into retrospective training and prospective test cohorts...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896419/why-not-intravenous-thrombolysis-in-patients-with-recurrent-stroke-within-3-months
#18
REVIEW
Chuanjie Wu, Di Wu, Jian Chen, Chuanhui Li, Xunming Ji
Acute ischemic stroke continues to be a very severe disorder that has significant impact on human health. Its treatment options are limited and alteplase remains the only American Food and Drug Administration-approved drug for patients with acute ischemic stroke. Furthermore, intravenous thrombolysis remains substantially underutilized, because it has rigorous indications and contraindications. Most patients simply do not meet these criteria and cannot receive thrombolytic treatment. Guidelines in many countries currently include a history of stroke within months as one of the exclusion criteria for intravenous thrombolysis...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29891068/cerebellar-stroke-in-adults-and-children
#19
Hakan Sarikaya, Maja Steinlin
Stroke in older age has reached epidemic proportions worldwide, and an increasing incidence has also been recognized in young adults and children. This chapter deals with stroke occurring in the cerebellum. Cerebellar stroke may present in a completely different way from common stroke syndromes in the anterior cerebral circulation. It can initially mimic benign vestibular neuritis and may later deteriorate into a life-threatening neurologic state. Posterior circulation stroke presents similarly in children and adults...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29889460/evaluation-of-ischemic-stroke-patients-with-systemic-cancer
#20
Ufuk Emre, Taskin Gunes, Irem Pinar, Furuzan Kokturk, Esengul Liman, Orhan Yağiz
Background and purpose: In cancer patients, an ischemic stroke can be seen as both a direct effect of cancer and a complication of treatment. This condition can negatively affect the follow-up and treatment of these patients. For this research, we aimed to evaluate the clinical features, stroke types and etiological features of ischemic stroke patients with histories of cancer or found to have cancer during the aetiological investigation. Methods: We retrospectively evaluated 100 patients (57 males, 43 females) who were hospitalized with acute stroke and determined to have the presence of cancer or a cancer history during the aetiological investigation between 2011 and 2016...
May 30, 2018: Ideggyógyászati Szemle
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