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Stroke prognosis

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https://www.readbyqxmd.com/read/29670826/characteristics-of-paramedian-pontine-arteries-disease-and-its-association-with-hemoglobina1c
#1
Haiyan Li, Yaqing Shu, Biao Hu, Yongqiang Dai, Yinyao Lin, Yilong Shan, Yuge Wang, Wei Cai, Zhengqi Lu
Objectives: The association of branch atherosclerotic disease (BAD) and diabetes mellitus (DM) in the territory of posterior circulation is rarely discussed. Intracranial BAD was divided into two different types: paramedian pontine arteries (PPA) disease (PPD) and lenticulostriate arteries (LSA) disease. The goal of the study was to evaluate the clinical characteristics of PPD and its association with hemoglobinA1c (HbA1c) in China. Materials and Methods: Radiologically confirmed PPD was defined as an isolated unilateral infarction extending to the ventral surface of the pons...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29668333/blood-biomarkers-in-ischemic-stroke-potential-role-and-challenges-in-clinical-practice-and-research
#2
Konstantinos Makris, Alexander Haliassos, Maria Chondrogianni, Georgios Tsivgoulis
Fast and accurate diagnosis of stroke is crucial for the immediate application of the right therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke cannot be identified based only on clinical assessment. CT or MRI imaging is required to rule out hemorrhagic stroke since thrombolytic therapy can lead to increased intracranial bleeding and further aggravation of hemorrhagic stroke. In addition, clinical situations that imitate the signs and symptoms of stroke may also impede the rapid diagnosis and treatment of stroke victims...
April 18, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29666887/reversible-lesions-of-the-corpus-callosum-with-initially-restricted-diffusion-in-a-series-of-caucasian-children
#3
Anthony Le Bras, Maia Proisy, Mathieu Kuchenbuch, Constantin Gomes, Catherine Tréguier, Sylvia Napuri, Emmanuel Quehen, Bertrand Bruneau
BACKGROUND: Reversible lesions of the corpus callosum with initial restricted diffusion on diffusion-weighted imaging (DWI) are rare and mainly described in the south Asiatic population. OBJECTIVE: The purpose of this study was to describe the clinical presentation, imaging findings, prognosis and etiology of transient restricted diffusion lesions of the corpus callosum in a series of Caucasian children. MATERIALS AND METHODS: Seven children presenting with a transient restricted DWI lesion of the corpus callosum were included...
April 17, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29666071/b-type-natriuretic-peptide-assessment-in-patients-undergoing-revascularization-for-left-main-coronary-artery-disease-analysis-from-the-excel-trial
#4
Björn Redfors, Shmuel Chen, Aaron Crowley, Ori Ben-Yehuda, Bernard J Gersh, Nicholas J Lembo, W Morris Brown, Adrian P Banning, David P Taggart, Patrick W Serruys, Arie Pieter Kappetein, Joseph F Sabik, Gregg W Stone
Background -Elevated B-type natriuretic peptide (BNP) is reflective of impaired cardiac function and is associated with worse prognosis among patients with coronary artery disease (CAD). We sought to assess the association between baseline BNP, adverse outcomes, and the relative efficacy of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) in patients with left main (LM) CAD. Methods -The EXCEL trial randomized patients with LMCAD and low or intermediate SYNTAX scores to PCI with everolimus-eluting stents versus CABG...
April 17, 2018: Circulation
https://www.readbyqxmd.com/read/29665308/calcified-cerebral-emboli-incidence-and-implications
#5
Miguel Bardon, Julian Hanson, Bill O'Brien, Adil Naeem
INTRODUCTION: Calcified cerebral emboli are an increasingly recognized cause of ischaemic stroke, although recognition amongst general radiologists and clinicians can be limited. Recent literature suggests that calcified cerebral emboli are likely more common than originally thought. This study aims to define the prevalence of calcified cerebral emboli as the most likely aetiology within a cohort of confirmed cases of acute stroke, as well as compare and contrast these cases with cases of 'incidental' intracranial calcification...
April 17, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29665290/timely-visualization-of-the-collaterals-formed-during-acute-ischemic-stroke-with-fe-3-o-4-nanoparticle-based-mr-imaging-probe
#6
Ting Wang, Yi Hou, Bo Bu, Wenxin Wang, Tiancong Ma, Chunyan Liu, Lan Lin, Lin Ma, Xin Lou, Mingyuan Gao
Ischemic stroke is one of the major leading causes for long-term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αv β3 -specific Fe3 O4 -Arg-Gly-Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of the collaterals. Rat models are constructed by occluding the middle cerebral artery for imaging studies of cerebral ischemia and ischemia-reperfusion on 7...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29664664/c-reactive-protein-levels-and-clinical-outcomes-in-stroke-patients-a-prospective-cohort-study
#7
Shahir Mazaheri, Elahe Reisi, Jalal Poorolajal, Masoud Ghiasian
BACKGROUND: The C-reactive protein (CRP) level, as an early prognostic factor of functional outcome after stroke, may be of clinical importance. The aim of this study was to determine the prognostic value of CRP on functional outcome and death in stroke patients. METHODS: This prospective study was conducted from 2015 to 2016 in Hamadan province, Iran. Patients with both ischemic and hemorrhagic stroke who were admitted in the first 12 hours were enrolled. The clinical characteristics of the patients were recorded at time of admission as well as on the fourth and the 90th day after stroke...
January 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29664343/peripheral-arterial-disease-changes-in-clinical-outcomes-and-therapeutic-strategies-in-two-cohorts-from-2002-to-2008-and-from-2008-to-2014-a-population-based-study
#8
Marta Baviera, Vittorio Bertelè, Fausto Avanzini, Tommaso Vannini, Mauro Tettamanti, Ida Fortino, Angela Bortolotti, Luca Merlino, Maria Carla Roncaglioni
Background The aim of our study was to evaluate whether treatments for peripheral artery disease changed in two different cohorts identified in 2002 and 2008, and whether this had an impact on mortality and major clinical outcomes after six years of follow-up. Methods Using administrative health databases of the largest region in Northern Italy, we identified patients admitted to hospital for peripheral artery disease in 2002 and 2008. Both cohorts were followed for six years. All cause death, acute coronary syndrome, stroke and major amputations, cardiovascular prevention drugs and revascularization procedures were collected...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29663285/exosomes-in-acquired-neurological-disorders-new-insights-into-pathophysiology-and-treatment
#9
REVIEW
Nicole Osier, Vida Motamedi, Katie Edwards, Ava Puccio, Ramon Diaz-Arrastia, Kimbra Kenney, Jessica Gill
Exosomes are endogenous nanovesicles that play critical roles in intercellular signaling by conveying functional genetic information and proteins between cells. Exosomes readily cross the blood-brain barrier and have promise as therapeutic delivery vehicles that have the potential to specifically deliver molecules to the central nervous system (CNS). This unique feature also makes exosomes attractive as biomarkers in diagnostics, prognostics, and therapeutics in the context of multiple significant public health conditions, including acquired neurological disorders...
April 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29661589/challenges-and-research-progress-of-the-use-of-mesenchymal-stem-cells-in-the-treatment-of-ischemic-stroke
#10
REVIEW
Jipeng Jiang, Yuting Wang, Baohu Liu, Xuyi Chen, Sai Zhang
Cerebral Ischemic Stroke (CIS) has become a hot issue in medical research because of the diversity of risk factors and the uncertainty of prognosis. In the field of regenerative medicine, mesenchymal stem cells (MSCs) have an increasingly prominent position due to their advantages of multiple differentiation, low immunogenicity and wide application. In the basic and clinical research of CIS, there are still some problems to be solved in the treatment of CIS. This paper will discuss the progresses and some obstacles of current MSCs for the treatment of CIS...
April 13, 2018: Brain & Development
https://www.readbyqxmd.com/read/29653277/a-crick-in-the-neck-followed-by-massage-offered-him-a-stroke-an-uncommon-case-of-vertebral-artery-dissection
#11
Gautam Dutta, Anita Jagetia, Arvind K Srivastava, Daljit Singh, Hukum Singh, Ravindra K Saran
We present an unusual case of vertebral artery dissection in a 30-year-old male patient following an episode of neck massage. He developed headache, nausea, vomiting, blurred vision, diplopia, dizziness, and ataxia following the procedure. We also discuss a review of the pathology, diagnosis, symptomatology, treatment, prognosis, and occurrence of this rare entity.
April 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29653270/decompressive-craniotomy-for-malignant-middle-cerebral-artery-infarction-optimal-timing-and-literature-review
#12
Ahmed Elsawaf, Ayman Galhom
OBJECT: To compare the results of early or delayed decompressive craniotomy (DC) for cases of malignant middle cerebral artery (MCA) infarction. STUDY DESIGN: Prospective comparative study METHODS: Prospective randomized study on consecutive series of a 46 patients with malignant MCA territory infarction. Patients were divided randomly into two groups: Group I; 27 patients who were followed till obvious deterioration of conscious level happened, Group II; 19 patients who were operated prophylactically in 6 hours of presentation even with no clear deterioration of conscious level or radiology's findings...
April 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29651234/pathophysiology-of-long-non-coding-rnas-in-ischemic-stroke
#13
REVIEW
Weimin Ren, Xiaobo Yang
Stroke is a neurological disease with high disability and fatality rates, and ischemic stroke accounts for 75% of all stroke cases. The underlying pathophysiologic processes of ischemic stroke include oxidative stress, toxicity of excitatory amino acids, excess calcium ions, increased apoptosis and inflammation. Long non-coding RNAs (lncRNAs) may participate in the regulation of the pathophysiologic processes of ischemic stroke as indicated by altered expression of lncRNAs in blood samples of acute ischemic stroke patients, animal models of focal cerebral ischemia and oxygen-glucose deprivation (OGD) cell models...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29649323/prognosis-of-cardiovascular-and-non-cardiovascular-multimorbidity-after-acute-coronary-syndrome
#14
Silvia Canivell, Olivier Muller, Baris Gencer, Dik Heg, Roland Klingenberg, Lorenz Räber, David Carballo, Christian Matter, Thomas Lüscher, Stephan Windecker, François Mach, Nicolas Rodondi, David Nanchen
OBJECTIVE: To examine the prognosis of patients with cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome compared to patients without prior multimorbidity. METHODS: This multicenter prospective cohort study in Switzerland included 5,635 patients hospitalized with acute coronary syndrome between 2009 and 2014, with a one-year follow-up period. We defined cardiovascular and non-cardiovascular multimorbidity as having at least two prior comorbidities before the index hospitalization...
2018: PloS One
https://www.readbyqxmd.com/read/29648662/long-term-causes-of-death-in-patients-with-infective-endocarditis-who-undergo-medical-therapy-only-or-surgical-treatment-a-nationwide-population-based-study
#15
Lauge Østergaard, Louise Bruun Oestergaard, Trine Kiilerich Lauridsen, Anders Dahl, Mavish Chaudry, Gunnar Gislason, Christian Torp-Pedersen, Niels Eske Bruun, Nana Valeur, Lars Køber, Emil Loldrup Fosbøl
OBJECTIVES: It is known that patients surviving infective endocarditis have a poor long-term prognosis; however, few studies have addressed the long-term causes of death in patients surviving the initial hospitalization. METHODS: Using Danish administrative registries, we identified patients admitted to a hospital with 1st time infective endocarditis in the period from January 1996 to December 2014, who were alive at the time of discharge. The study population was categorized into (i) patients undergoing medical therapy only and (ii) patients undergoing surgical and medical treatment...
April 10, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29643606/relationship-between-psychophysiological-factors-and-prognosis-for-activities-of-daily-living-in-patients-with-stroke-in-a-recovery-rehabilitation-unit-a-preliminary-study
#16
Shogo Kawada, Ryohei Goto
[Purpose] The objective of the present study was to examine the factors, including physical and mental functions, that are associated with the prognosis for activities of daily living in patients with stroke in a recovery rehabilitation unit. [Subjects and Methods] The subjects were 13 patients with stroke who were admitted to the recovery rehabilitation unit of Tokai Memorial Hospital between March and October 2014 and followed up for 2 months. Their physical and mental functions were evaluated at the time of admission and the relationship between these functions and activities of daily living was assessed 2 months later...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29642385/micrornas-as-potential-mediators-for-cigarette-smoking-induced-atherosclerosis
#17
Yuka Yokoyama, Nathan Mise, Yuka Suzuki, Saeko Tada-Oikawa, Kiyora Izuoka, Lingyi Zhang, Cai Zong, Akira Takai, Yoshiji Yamada, Sahoko Ichihara
Smoking increases the risk of atherosclerosis-related events, such as myocardial infarction and ischemic stroke. Recent studies have examined the expression levels of altered microRNAs (miRNAs) in various diseases. The profiles of tissue miRNAs can be potentially used in diagnosis or prognosis. However, there are limited studies on miRNAs following exposure to cigarette smoke (CS). The present study was designed to dissect the effects and cellular/molecular mechanisms of CS-induced atherosclerogenesis. Apolipoprotein E knockout (ApoE KO) mice were exposed to CS for five days a week for two months at low (two puffs/min for 40 min/day) or high dose (two puffs/min for 120 min/day)...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629256/european-society-of-cardiology-proposed-diagnostic-echocardiographic-algorithm-in-elective-patients-with-clinical-suspicion-of-infective-endocarditis-diagnostic-yield-and-prognostic-implications-in-clinical-practice
#18
Andrea Barbieri, Francesca Mantovani, Roberta Lugli, Francesca Bursi, Matteo Fabbri, Ylenia Bartolacelli, Marcella Manicardi, Guglielmo Stefanelli, Cristina Mussini, Giuseppe Boriani
Background: Echocardiography plays a central role in diagnosing infective endocarditis (IE). Accordingly, the European Society of Cardiology (ESC) has proposed a diagnostic echocardiographic algorithm. However, new studies are still needed to evaluate the degree of implementation of these guidelines in clinical practice and their consequences on incidence and prognosis of IE. Aim: This study aims to investigate the diagnostic yield of the ESC proposed echocardiographic algorithm in patients with suspected IE...
January 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29628951/clinical-and-radiographic-predictors-of-intracerebral-hemorrhage-outcome
#19
REVIEW
Fawaz Al-Mufti, Ahmad M Thabet, Tarundeep Singh, Mohammad El-Ghanem, Krishna Amuluru, Chirag D Gandhi
Background: Intracerebral hemorrhage (ICH) represents 10-15% of all stroke cases in the US annually. Fewer than 40% of these patients ever reach long-term functional independence, and mortality rate is roughly 40% at 1 month. Due to the high morbidity and mortality rates after ICH, early detection of high-risk patients would be beneficial in directing the management course and goals of care. This review aims to discuss relevant clinical and radiographic characteristics that can serve as predictors of poor prognosis and examine their efficacy in predicting patient outcomes after ICH...
February 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29625717/prospective-observational-study-in-elderly-patients-with-non-valvular-atrial-fibrillation-rationale-and-design-of-the-all-nippon-af-in-the-elderly-anafie-registry
#20
Hiroshi Inoue, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Ken Okumura, Yukihiro Koretsune, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Masahiro Akishita, Naoyuki Hasebe, Kazuomi Kario, Yuji Mizokami, Ken Nagata, Masato Nakamura, Yasuo Terauchi, Takatsugu Yamamoto, Satoshi Teramukai, Tetsuya Kimura, Jumpei Kaburagi, Atsushi Takita
BACKGROUND: Although anticoagulation effectively prevents stroke in patients with atrial fibrillation (AF), it has been underused in elderly AF patients for many reasons, mainly because of knowledge gaps regarding cardiovascular treatment of these populations with multiple comorbidities and poor prognosis. The objectives of the All Nippon AF In the Elderly (ANAFIE) Registry are to collect real-world information about the clinical status of patients with non-valvular AF (NVAF) aged ≥75 years, current status of anticoagulant therapy, and prognosis with/without anticoagulation to establish a database for this specific patient population that is increasing remarkably worldwide...
April 3, 2018: Journal of Cardiology
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